Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(CCO)CC1 CHEMBL3961316 IC50 0.1 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(C(=O)CN)CC1 CHEMBL3962177 IC50 0.1 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(CC(N)=O)CC1 CHEMBL3939027 IC50 0.2 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(C[C@@H](O)C(F)(F)F)CC1 CHEMBL4108038 IC50 0.2 nM
Cc1nc(-c2cccnc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCN(CC(N)=O)CC3)ccc2n1 CHEMBL3900391 IC50 0.2 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCOCC1 CHEMBL3926405 IC50 0.2 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4cccc(-c5cccnc5)c4)cn3n2)c1C1CCOCC1 CHEMBL3932533 IC50 0.2 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(CCCF)CC1 CHEMBL3936532 IC50 0.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1N1CCN(Cc2ccon2)CC1 CHEMBL3935382 IC50 0.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N)c4)cn3n2)c1N1CCN(Cc2ccon2)CC1 CHEMBL3971152 IC50 0.3 nM
COCC(=O)N1CCC(c2c(-c3ccc4nc(NC(=O)c5ccnc(F)c5)cn4n3)c(-c3ccc(F)cc3)nn2C)CC1 CHEMBL3943491 IC50 0.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(C(=O)c2ccon2)CC1 CHEMBL3915816 IC50 0.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(C(=O)c2cncs2)CC1 CHEMBL3978116 IC50 0.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(CC(N)=O)CC1 CHEMBL3922511 IC50 0.3 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCN(CC(N)=O)CC3)ccc2n1 CHEMBL3981952 IC50 0.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCOCC1 CHEMBL3910924 IC50 0.3 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCOCC3)ccc2n1 CHEMBL3906580 IC50 0.3 nM
Cc1nc(-c2cccnc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCOCC3)ccc2n1 CHEMBL3986585 IC50 0.3 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cncc(-c5ccc(C#N)cc5)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3923163 IC50 0.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(Cc2ccon2)CC1 CHEMBL3926825 IC50 0.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(CCCF)CC1 CHEMBL3931942 IC50 0.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(CCC#N)CC1 CHEMBL3942825 IC50 0.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(C[C@H](O)C(F)(F)F)CC1 CHEMBL3894506 IC50 0.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1C1CCN(CC(N)=O)CC1 CHEMBL3944464 IC50 0.4 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCN(CCC#N)CC3)ccc2n1 CHEMBL3947732 IC50 0.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1-c1ccncc1 CHEMBL3948521 IC50 0.4 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cncc(-c5ccccc5)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3963973 IC50 0.5 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(C(=O)C2CC2)CC1 CHEMBL3934241 IC50 0.5 nM
Cc1nc(-c2cccnc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3N3CCOCC3)ccc2n1 CHEMBL3893281 IC50 0.5 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(C(=O)CC(F)(F)F)CC1 CHEMBL3895318 IC50 0.5 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1C1CCN(CCCF)CC1 CHEMBL3915283 IC50 0.5 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1C1CCOCC1 CHEMBL3938867 IC50 0.5 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1-c1ccncc1 CHEMBL3916656 IC50 0.5 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCNCC1 CHEMBL3913933 IC50 0.6 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(CCC#N)CC1 CHEMBL3953610 IC50 0.6 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1N1CCN(C(=O)CC(F)(F)F)CC1 CHEMBL3950183 IC50 0.6 nM
CN1CCN(c2c(-c3ccc4nc(NC(=O)c5ccnc(F)c5)cn4n3)c(-c3ccc(F)cc3)nn2C)CC1 CHEMBL3903967 IC50 0.7 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3N3CCOCC3)ccc2n1 CHEMBL3947948 IC50 0.7 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(CCC(F)(F)F)CC1 CHEMBL3939036 IC50 0.7 nM
Cc1nc(-c2cccnc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCN(CCC(F)(F)F)CC3)ccc2n1 CHEMBL3974768 IC50 0.7 nM
COCCN1CCN(c2c(-c3ccc4nc(NC(=O)c5ccnc(F)c5)cn4n3)c(-c3ccc(F)cc3)nn2C)CC1 CHEMBL3909456 IC50 0.73 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCOCC1 CHEMBL3952882 IC50 0.74 nM
COc1cc(C(=O)Nc2cn3nc(-c4c(-c5ccc(F)cc5)nn(C)c4N4CCNCC4)ccc3n2)ccn1 CHEMBL3933835 IC50 0.8 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1N1CCNCC1 CHEMBL3907925 IC50 0.8 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1N1CCN(Cc2ccon2)CC1 CHEMBL3951296 IC50 0.8 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1N1CCNCC1 CHEMBL3889846 IC50 0.9 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCNCC1 CHEMBL3916526 IC50 0.9 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1-c1ccncc1 CHEMBL3921603 IC50 0.9 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4cccc(-c5cccnc5)c4)cn3n2)c1-c1ccncc1 CHEMBL3976515 IC50 0.9 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cccc(N5CCOCC5)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3949364 IC50 1.0 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(C[C@@H](O)C(F)(F)F)CC1 CHEMBL4107936 IC50 1.0 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1N1CCN(C(=O)c2ccon2)CC1 CHEMBL3932369 IC50 1.0 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1N1CCN(C(=O)c2ccon2)CC1 CHEMBL3893406 IC50 1.0 nM
Cc1nc(-c2cccnc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCN(Cc4ccon4)CC3)ccc2n1 CHEMBL3912884 IC50 1.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(F)nc(F)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3949881 IC50 1.1 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(Cc2ccon2)CC1 CHEMBL3902265 IC50 1.1 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCN(CCC(F)(F)F)CC3)ccc2n1 CHEMBL3981157 IC50 1.1 nM
Cc1nc(-c2cccnc2)sc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3954265 IC50 1.2 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(C(=O)CC(F)(F)F)CC1 CHEMBL3909877 IC50 1.2 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(Cl)nc5ccccc45)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3899562 IC50 1.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCN(CCO)CC1 CHEMBL3895083 IC50 1.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1N1CCN(CCC(F)(F)F)CC1 CHEMBL3965134 IC50 1.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1N1CCN(CCCF)CC1 CHEMBL3905231 IC50 1.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4cc(F)nc(F)c4)cn3n2)c1N1CCOCC1 CHEMBL3909742 IC50 1.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCN(C2CC2)CC1 CHEMBL3922012 IC50 1.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCN(Cc2ccon2)CC1 CHEMBL3981677 IC50 1.4 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCNCC3)ccc2n1 CHEMBL3957543 IC50 1.4 nM
Cn1cc(-c2ccnc3[nH]ncc23)c(-c2ccc(F)cc2)n1 CHEMBL5396363 IC50 1.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(C[C@H](O)C(F)(F)F)CC1 CHEMBL3889600 IC50 1.5 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1C1CCNCC1 CHEMBL3902838 IC50 1.5 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCN(Cc2nccs2)CC1 CHEMBL3890290 IC50 1.5 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1N1CCN(CCC(F)(F)F)CC1 CHEMBL3895315 IC50 1.6 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1N1CCN(C(=O)CC(F)(F)F)CC1 CHEMBL3922374 IC50 1.6 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cccc(-c5cccnc5)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3940555 IC50 1.7 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cccc(-c5ccncc5)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3896955 IC50 1.7 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1C1CCN(CCC(F)(F)F)CC1 CHEMBL3939825 IC50 1.7 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCN(Cc4ccon4)CC3)ccc2n1 CHEMBL3910319 IC50 1.7 nM
Cn1ncc(-c2nc(N[C@H]3CC[C@H](N)CC3)ncc2Cl)c1CC1CC1 CHEMBL4754493 IC50 1.8 nM
COc1cc(F)cc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)c1 CHEMBL3935757 IC50 1.9 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cnc(C(F)(F)F)nc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3969763 IC50 1.9 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cncc(O)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3959158 IC50 2.0 nM
O=C(Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1)c1cccc(-c2cccnc2)c1 CHEMBL3895186 IC50 2.0 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCN(C)CC3)ccc2n1 CHEMBL3933511 IC50 2.1 nM
Cn1cc(-c2ccnc3[nH]ccc23)c(-c2ccc(F)cc2)n1 CHEMBL5419541 IC50 2.2 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(Br)cc4F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3974872 IC50 2.3 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3907142 IC50 2.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCN(C2CCOCC2)CC1 CHEMBL3923060 IC50 2.4 nM
Cc1nc(-c2cccnc2)sc1C(=O)Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3900211 IC50 2.5 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N)c4)cn3n2)c1N1CCNCC1 CHEMBL3936095 IC50 2.5 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N)c4)cn3n2)c1N1CCN(CCC(F)(F)F)CC1 CHEMBL3909481 IC50 2.5 nM
Cc1nc(-c2cccnc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCNCC3)ccc2n1 CHEMBL3893731 IC50 2.5 nM
Cn1cc(-c2ccc3nc(NC(=O)c4csc(Br)n4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3972492 IC50 2.6 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cccc(F)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3946336 IC50 2.6 nM
Cc1ccncc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3941604 IC50 2.6 nM
Cn1cc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)cn1 CHEMBL3977481 IC50 2.6 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCN(Cc2cc[nH]n2)CC1 CHEMBL3903876 IC50 2.6 nM
CN1CCC(c2c(-c3ccc4nc(NC(=O)c5ccncc5)cn4n3)c(-c3ccc(F)cc3)nn2C)CC1 CHEMBL3925387 IC50 2.7 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccncc4F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3981324 IC50 2.8 nM
CN(C)c1ccc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)cn1 CHEMBL3953061 IC50 2.8 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(CCS(C)(=O)=O)CC1 CHEMBL3970214 IC50 2.9 nM
Cn1cc(-c2ccnc3[nH]ccc23)c(-c2ccc(F)cn2)n1 CHEMBL5419688 IC50 2.9 nM
O=C(Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1)c1ccncc1 CHEMBL3967723 IC50 3.0 nM
Cc1nc(-c2cccnc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCN(C)CC3)ccc2n1 CHEMBL3982756 IC50 3.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cncs4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3892824 IC50 3.1 nM
O=C(Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1)c1ccc(C(F)(F)F)nc1 CHEMBL3907683 IC50 3.1 nM
O=C(Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1)c1ccnc(F)c1 CHEMBL3960818 IC50 3.2 nM
Cc1ncccc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3982144 IC50 3.3 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ncc(-c5ccccn5)s4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3893155 IC50 3.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(CCC(F)(F)F)CC1 CHEMBL3955665 IC50 3.3 nM
O=C(Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1)c1ccncc1F CHEMBL3952116 IC50 3.5 nM
Cc1c[nH]nc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3927972 IC50 3.6 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCN(Cc2cscn2)CC1 CHEMBL3970297 IC50 3.6 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3986343 IC50 3.7 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccno4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3909525 IC50 3.7 nM
CN(C)Cc1cccc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)c1 CHEMBL3975103 IC50 3.8 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(-n5cccn5)nc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3932627 IC50 3.8 nM
CCN(CC)Cc1ccc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)cc1 CHEMBL3930043 IC50 3.9 nM
Nc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCN(Cc3ccon3)CC2)n1 CHEMBL4128865 IC50 3.9 nM
COc1ccc(/C=C/C(=O)Nc2cc(-c3[nH]c(SC)nc3-c3ccc(F)cc3)ccn2)c(OC)c1 CHEMBL569114 IC50 4.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(CO)cc4F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3900216 IC50 4.0 nM
COc1cc2nc(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cnn(C)c3)[nH]c2cc1Cl CHEMBL4855324 IC50 4.0 nM
[2H]C([2H])([2H])C1(C([2H])([2H])[2H])Cn2nc(-c3ccc(F)cn3)c(-c3ccnc4[nH]ncc34)c2CO1 CHEMBL5081774 IC50 4.0 nM
CN1Cc2nccc(-c3cn(C)nc3-c3ccc(F)cc3)c2C1=O CHEMBL5303425 IC50 4.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cncc(Cl)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3905181 IC50 4.1 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(C#N)ccc4F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3910402 IC50 4.1 nM
Cn1cc(-c2ccc3nc(NC(=O)C45CC6CC(CC(C6)C4)C5)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3924829 IC50 4.1 nM
Cn1cc(-c2ccc3nc(NC(=O)C4CCCCCC4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3917728 IC50 4.2 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccccc4)c(C#N)n3n2)c(-c2ccc(F)cc2)n1 CHEMBL3904017 IC50 4.2 nM
Cc1nc(-c2ccccn2)sc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3951515 IC50 4.3 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccccc4F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3929204 IC50 4.3 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(OCC(F)(F)F)nc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3919122 IC50 4.4 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3925884 IC50 4.5 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCN(Cc2cocn2)CC1 CHEMBL3899096 IC50 4.5 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cscn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3975556 IC50 4.6 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(F)cc(F)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3943891 IC50 4.8 nM
O=C(Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1)c1cc(F)nc(F)c1 CHEMBL3924423 IC50 4.8 nM
COc1ccc(/C=C/C(=O)Nc2cc(-c3[nH]c([S+](C)[O-])nc3-c3ccc(F)cc3)ccn2)c(OC)c1 CHEMBL572006 IC50 5.0 nM
CC(Nc1nccc(-c2c(-c3ccc(F)cc3)nc3occn23)n1)c1ccccc1 CHEMBL1990288 pKi 5.012 nM
Cn1cc(-c2ccc3nc(NC(=O)C4CCCCC4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3889723 IC50 5.1 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3940237 IC50 5.2 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(Cl)ccc4F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3896785 IC50 5.2 nM
Cn1cc(-c2ccc3nc(NC(=O)c4csc(-c5ccncc5)n4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3966079 IC50 5.4 nM
Cn1cc(-c2ccc3nc(NC(=O)C4CCOCC4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3982877 IC50 5.4 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccccc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3958671 IC50 5.4 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cnn(C)c4Cl)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3932365 IC50 5.5 nM
Cn1cc(-c2ccc3nc(NC(=O)C45CCCC(CCC4)C5)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3902286 IC50 5.5 nM
Cc1nc(-c2ccccn2)sc1C(=O)Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3951534 IC50 5.5 nM
COc1ccc(F)c(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)c1 CHEMBL3969708 IC50 5.6 nM
Cn1cc(-c2ccc3nc(NC(=O)C4CCCC4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3907589 IC50 5.6 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccccc4)c(F)n3n2)c(-c2ccc(F)cc2)n1 CHEMBL3981818 IC50 5.6 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(C#N)c(F)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3902451 IC50 5.7 nM
COc1c(F)cc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)cc1F CHEMBL3940974 IC50 5.7 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(CN5CCCC5)cc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3941685 IC50 5.8 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(C#N)nc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3960227 IC50 5.8 nM
Cn1cc(-c2ccnc3c2OCCNC3)c(-c2ccc(F)cc2)n1 CHEMBL2420703 IC50 6.0 nM
Cc1nocc1C(=O)Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3919335 IC50 6.0 nM
COc1cc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)ccn1 CHEMBL3978386 IC50 6.1 nM
CN1CCC(F)(Cn2cnc(-c3ccc(F)cn3)c2-c2ccnc3[nH]ccc23)CC1 CHEMBL5303449 IC50 6.1 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3936537 IC50 6.2 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(Cl)cc4F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3972305 IC50 6.3 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(F)ccc4F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3986616 IC50 6.3 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cccnc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3903330 IC50 6.4 nM
Cc1nc(C(F)(F)F)ccc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3915828 IC50 6.5 nM
Cn1cc(-c2ccnc(C3COCCN3)c2)c(-c2ccc(F)cc2)n1 CHEMBL2420704 IC50 6.6 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(OC(F)F)cc4F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3913183 IC50 6.9 nM
Cn1cc(-c2ccc3nc(NC(=O)C4CC4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3981164 IC50 7.0 nM
COc1ccncc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3962919 IC50 7.1 nM
Cn1cc(-c2ccc3nc(NC(=O)C4CCC4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3939255 IC50 7.1 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(F)cc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3912546 IC50 7.2 nM
Cc1nocc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3895913 IC50 7.3 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ncccc4Cl)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3914746 IC50 7.3 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccnnc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3959875 IC50 7.4 nM
Cn1cc(-c2ccc3nc(NC(=O)C4CC5CC46CC56)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3930261 IC50 7.4 nM
Cc1cc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)ccn1 CHEMBL3916882 IC50 7.6 nM
Cn1cc(-c2ccc3nc(NC(=O)c4csc(-c5ccccc5)n4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3891165 IC50 7.7 nM
Nc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCCCC2)n1 CHEMBL1951415 IC50 7.8 nM
CN(C)Cc1ccccc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3969521 IC50 7.8 nM
COc1cccc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)c1F CHEMBL3963771 IC50 7.8 nM
CCc1nccn2c(-c3ccnc(NCC(C)(C)O)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL2001547 pKi 7.943 nM
CC(C)(O)CNc1nccc(-c2c(-c3ccc(F)cc3F)nc3c(CC4CC4)nccn23)n1 CHEMBL1994040 pKi 7.943 nM
Fc1ccc(-c2nc3cnccn3c2-c2ccnc(NCC3CC3)n2)cc1 CHEMBL1990904 pKi 7.943 nM
CC(=O)N1CCC(Nc2nccc(-c3c(-c4ccc(F)cc4)nc4occn34)n2)CC1 CHEMBL1986781 pKi 7.943 nM
CC(C)(CO)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3c(CCN)nccn23)n1 CHEMBL1982383 pKi 7.943 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cnccc4C(F)(F)F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3984487 IC50 8.0 nM
Cc1nc(-c2ccccc2)sc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3980426 IC50 8.3 nM
Cn1cc(-c2ccc3nc(NC(=O)C45CC6CC(C)(CC(C)(C6)C4)C5)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3893301 IC50 8.3 nM
O=C(Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1)c1csc(-c2ccncc2)n1 CHEMBL3976870 IC50 8.5 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(F)cc(C#N)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3963299 IC50 8.9 nM
Fc1cccc(-n2cnc3c(NCc4nc5ccccc5s4)nc(N4CCOCC4)nc32)c1 CHEMBL4211301 IC50 9.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(O)ncn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3941721 IC50 9.4 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cnccn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3937466 IC50 9.5 nM
CC(C)(CO)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3c(OCC(F)(F)F)nccn23)n1 CHEMBL2001957 pKi 10.0 nM
Fc1ccc(-c2nc3sccn3c2-c2ccncc2)cc1 CHEMBL2000508 pKi 10.0 nM
CC(C)Oc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL2000429 pKi 10.0 nM
CC(C)(CO)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3c(CC4CC4)nccn23)n1 CHEMBL1991800 pKi 10.0 nM
COc1ccccc1CC(=O)Nc1nc2ccc(C(F)(F)F)cc2s1 CHEMBL3235552 IC50 10.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(CCN5CCCC5)nc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3964687 IC50 10.0 nM
Fc1ccc(F)c(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)c1 CHEMBL4214571 IC50 10.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(C(C)(C)C)ncn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3936977 IC50 10.1 nM
COc1cc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)nc(OC)n1 CHEMBL3913000 IC50 10.2 nM
Cn1cc(-c2ccc3nc(NC(=O)CC(F)(F)F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3921458 IC50 10.3 nM
COc1ncccc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3889710 IC50 10.6 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccncn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3897438 IC50 10.7 nM
CC1(C)Cn2nc(-c3ccc(F)cn3)c(-c3ccnc4[nH]ccc34)c2CO1 CHEMBL5435963 IC50 11.0 nM
CC1(C)CCc2c(-c3ccnc4[nH]ncc34)c(-c3ccc(F)cn3)nn2C1 CHEMBL5428427 IC50 11.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccccn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3985580 IC50 11.8 nM
CCc1ccc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)nc1 CHEMBL3983364 IC50 11.9 nM
Nc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCNCC2)n1 CHEMBL274064 pKi 12.59 nM
Cc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1991678 pKi 12.59 nM
COc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1995832 pKi 12.59 nM
CNCc1cc(-c2cn(C)nc2-c2ccc(F)cc2)ccn1 CHEMBL2420702 IC50 12.9 nM
CN1Cc2nccc(-c3cn(C)nc3-c3ccc(F)cc3)c2C1=O CHEMBL4445830 IC50 13.0 nM
Cn1cc(-c2ccnc(CO)c2)c(-c2ccc(F)cc2)n1 CHEMBL2420701 IC50 14.2 nM
COc1cccc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)n1 CHEMBL3946925 IC50 14.2 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(F)c(C#N)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3938335 IC50 14.4 nM
Cn1cc(-c2ccc3nc(NC(=O)Nc4ccccc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3977152 IC50 14.6 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 15.0 nM
COc1cnc(/C=C/c2ccc(F)cc2)nc1-c1cc2c([nH]1)CCNC2=O CHEMBL2203553 IC50 15.0 nM
COc1cc(CC(=O)Nc2nc3ccc(C(F)(F)F)cc3s2)cc(OC)c1OC CHEMBL3235572 IC50 15.0 nM
COCCNc1nccc(-c2c(-c3ccc(F)cc3)nc3cnccn23)n1 CHEMBL1969372 pKi 15.85 nM
CC(C)Oc1nccn2c(-c3ccnc(NCC(C)(C)O)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1984700 pKi 15.85 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 15.85 nM
CN(C)CC(C)(C)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3cnccn23)n1 CHEMBL1976093 pKi 15.85 nM
COc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3)nc12 CHEMBL2005792 pKi 15.85 nM
CC(C)(CO)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3cnccn23)n1 CHEMBL1991395 pKi 15.85 nM
Cc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3)nc12 CHEMBL1987648 pKi 15.85 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ncccn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3937324 IC50 16.0 nM
Cn1cc(-c2ccc3nc(Nc4ncccn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3894100 IC50 16.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccncc4)c(Br)n3n2)c(-c2ccc(F)cc2)n1 CHEMBL3958331 IC50 17.0 nM
Oc1ccc(CCn2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)cc1 CHEMBL5397065 IC50 18.0 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 19.95 nM
COCC(C)(C)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3c(C)nccn23)n1 CHEMBL1982563 pKi 19.95 nM
Cc1cn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3F)nc2c(C)n1 CHEMBL2000408 pKi 19.95 nM
COc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCNCC2)n1 CHEMBL95692 pKi 19.95 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccnc(C(C)(C)C)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3923511 IC50 20.4 nM
COc1cnc(COc2ccc(F)cc2)cc1-c1cc2c([nH]1)CCNC2=O CHEMBL2203561 IC50 21.0 nM
COc1cnc(Nc2ccccc2)nc1-c1cc2c([nH]1)CCNC2=O CHEMBL2203556 IC50 22.0 nM
COc1cnc(NCc2ccccc2)nc1-c1cc2c([nH]1)CCNC2=O CHEMBL2203555 IC50 22.0 nM
O=C(Nc1nc2ccc(C(F)(F)F)cc2[nH]1)c1csc(NC(=O)c2ccccc2OC(F)(F)F)n1 CHEMBL3337854 IC50 22.0 nM
O=C(Cc1cccc(Cl)c1)Nc1nc2ccc(C(F)(F)F)cc2s1 CHEMBL3235538 IC50 23.0 nM
CN1CCC(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)CC1 CHEMBL3914705 IC50 23.9 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccccc4)c(Cl)n3n2)c(-c2ccc(F)cc2)n1 CHEMBL3949680 IC50 24.5 nM
Cn1cc(-c2ccc3nc(NC(=O)c4csc(-c5ccc(Cl)cc5)n4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3967195 IC50 24.6 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cccc(C(F)(F)F)n4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3928838 IC50 24.7 nM
COc1nccc(-c2c(-c3ccc(F)cc3)ncn2[C@H]2CC[C@H](O)CC2)n1 CHEMBL97162 Ki 25.0 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 25.12 nM
CCc1nc(-c2cccc(C)c2)c(-c2ccnc(NC(=O)c3ccccc3)c2)s1 CHEMBL363648 pKi 25.12 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1F CHEMBL1981079 pKi 25.12 nM
CN(C)CC(C)(C)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3occn23)n1 CHEMBL1968127 pKi 25.12 nM
Cc1nccn2c(-c3ccnc(NCC4(O)CC4)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1965589 pKi 25.12 nM
COc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCC(O)CC2)n1 CHEMBL256835 pKi 25.12 nM
CN1CCN(C2CCC(n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1997617 pKi 25.12 nM
CSc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL17370 pKi 25.12 nM
O=C(Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1)C1CC1 CHEMBL3987095 IC50 28.1 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(-c5ccc(F)cc5)ncn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3899986 IC50 30.4 nM
Cn1cc(-c2ccc3nc(NC(=O)c4nccs4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3921992 IC50 30.5 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccccc3)c2C2CC2)C1 CHEMBL3950647 IC50 31.0 nM
CC(C)(CO)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3c(Cl)nccn23)n1 CHEMBL1969735 pKi 31.62 nM
O=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21 CHEMBL1997129 pKi 31.62 nM
Cc1cc(C)c2c(n1)sc1c(N)ncnc12 CHEMBL504950 pKi 31.62 nM
Cc1nccn2c(-c3ccnc(NCCC(C)(C)O)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1978200 pKi 31.62 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 pKi 31.62 nM
Cc1nccn2c(-c3ccnc(NCC(C)(C)O)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1996500 pKi 31.62 nM
CC(C)COc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3)nc12 CHEMBL1984842 pKi 31.62 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 31.62 nM
Nc1ncnc2c1c(COc1cccc(Cl)c1)nn2C1CCOCC1 CHEMBL2069623 IC50 32.0 nM
Cn1cc(-c2cc(N)nc3[nH]ccc23)c(-c2ccc(F)cn2)n1 CHEMBL5410848 IC50 32.0 nM
COc1ccc(/C=C/C(=O)Nc2cc(-c3c(-c4ccc(F)cc4)noc3C(C)C)ccn2)c(OC)c1 CHEMBL571142 IC50 33.0 nM
COc1ccc(CC(=O)Nc2nc3ccc(C(F)(F)F)cc3s2)cc1 CHEMBL3235560 IC50 33.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(C(F)(F)F)cn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3910210 IC50 34.6 nM
NC1=NC(=O)/C(=C2\CCNC(=O)c3[nH]c(Br)cc32)N1 CHEMBL361708 IC50 35.0 nM
COc1cnc(COc2ccc(F)cc2F)cc1-c1cc2c([nH]1)CCNC2=O CHEMBL2203562 IC50 36.0 nM
C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL10 Kd 37.0 nM
Cc1cccc(CNc2nc(N3CCOCC3)nc3c2ncn3-c2cccc(F)c2)n1 CHEMBL4205929 IC50 37.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccccc4)c(Br)n3n2)c(-c2ccc(F)cc2)n1 CHEMBL3944359 IC50 38.8 nM
CS(=O)(=O)c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL280317 Ki 39.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 39.81 nM
COc1cnc(COc2ccc(F)c(F)c2)cc1-c1cc2c([nH]1)CCNC2=O CHEMBL2203563 IC50 40.0 nM
c1ccc(-c2nnc(N3CCN(c4ncccn4)CC3)cc2-c2ccncc2)cc1 CHEMBL4632881 Ki 40.0 nM
CC(C)(C)n1nc(-c2ccc(Cl)cc2)c2c(N)ncnc21 CHEMBL406845 IC50 41.0 nM
COc1ccc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)c(OC)n1 CHEMBL3913546 IC50 41.0 nM
COc1cccc(CC(=O)Nc2nc3ccc(C(F)(F)F)cc3s2)c1 CHEMBL3235556 IC50 42.0 nM
Fc1cccc(-n2cnc3c(NCc4nc5ccccc5o4)nc(N4CCOCC4)nc32)c1 CHEMBL4215691 IC50 42.0 nM
O=C(Nc1nc2cc(Cl)c(F)cc2[nH]1)c1coc(NC(=O)c2ccccc2OC(F)(F)F)n1 CHEMBL5435232 IC50 42.0 nM
Fc1cccc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)c1 CHEMBL4211454 IC50 44.0 nM
CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)nc(SCCN)nc12 CHEMBL4540226 IC50 45.0 nM
Fc1ccc(-c2nn3c(c2-c2ccnc(NC4CCOCC4)n2)COCC3)cc1 CHEMBL5401718 IC50 45.0 nM
O=C(Cc1ccccc1)Nc1nc2ccc(C(F)(F)F)cc2s1 CHEMBL3235563 IC50 47.0 nM
CN1CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4ccsc4)c3n2)CC1 CHEMBL4203268 IC50 47.0 nM
Fc1cccc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)c1F CHEMBL4203375 IC50 48.0 nM
Cn1cc(-c2ccncc2)c(-c2ccc(F)cc2)n1 CHEMBL2420700 IC50 48.1 nM
Clc1cc2nc(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cccnc3)[nH]c2cc1Cl CHEMBL4218827 IC50 50.0 nM
CN1CCN(c2ccc(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cccc(F)c3)nc2)CC1 CHEMBL4211222 IC50 50.0 nM
c1ccc(-c2nnc(N3CCNCC3)cc2-c2ccncc2)cc1 CHEMBL4639028 IC50 50.0 nM
Nc1ncnc2c1sc1ncnc(N)c12 CHEMBL1976090 pKi 50.12 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL225519 pKi 50.12 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 50.12 nM
CC(C)S(=O)(=O)n1c(N)nc2ccc(-c3c(-c4ccc(F)cc4)nc4sccn34)cc21 CHEMBL2003657 pKi 50.12 nM
Cn1cc(-c2ccc3nc(NC(=O)OCc4ccccc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3965423 IC50 51.5 nM
Cc1cnc2[nH]ccc2c1-c1cn(C)nc1-c1ccc(F)cn1 CHEMBL5396125 IC50 52.0 nM
Fc1cc(F)cc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)c1 CHEMBL4207079 IC50 53.0 nM
Cc1c(NC(=O)c2ccccc2)nc2ccc(-c3cn(C)nc3-c3ccc(F)cc3)nn12 CHEMBL3901909 IC50 54.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3ccsc3)nc2c1F CHEMBL4206247 IC50 54.0 nM
Nc1nc(NCc2nc3c(F)c(F)ccc3[nH]2)c2ncn(-c3cccc(F)c3)c2n1 CHEMBL4211791 IC50 55.0 nM
O=C(Cc1ccc(Cl)c(Cl)c1)Nc1nc2ccc(C(F)(F)F)cc2s1 CHEMBL3235564 IC50 56.0 nM
CC(=O)c1c(-c2ccncc2)[nH]c(-c2ccncc2)c1C CHEMBL526901 Kd 58.0 nM
COc1cnc(COc2ccc(F)cc2)nc1-c1cc2c([nH]1)CCNC2=O CHEMBL2203559 IC50 58.0 nM
Oc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL278041 Kd 59.0 nM
COc1cnc(COc2ccc(F)cc2C)cc1-c1cc2c([nH]1)CCNC2=O CHEMBL2203564 IC50 59.0 nM
CC1(C)Cn2nc(-c3ccc(F)cn3)c(-c3ccnc4[nH]ncc34)c2CO1 CHEMBL5095777 IC50 62.0 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 63.1 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCCCC2)n1 CHEMBL2006439 pKi 63.1 nM
Clc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 CHEMBL1969588 pKi 63.1 nM
Fc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL316264 pKi 63.1 nM
O=C(Cc1ccc(Cl)cc1)Nc1nc2ccc(C(F)(F)F)cc2s1 CHEMBL3235545 IC50 65.0 nM
COc1cnc(-c2cnc3ccccc3c2)nc1-c1cc2c([nH]1)CCNC2=O CHEMBL2203552 IC50 68.0 nM
O=C(Cc1ccccc1Cl)Nc1nc2ccc(C(F)(F)F)cc2s1 CHEMBL3235542 IC50 68.0 nM
OCC1CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4cccc(F)c4)c3n2)CC1 CHEMBL4209917 IC50 69.0 nM
Cn1cc(-c2c(C#N)cnc3[nH]ccc23)c(-c2ccc(F)cn2)n1 CHEMBL5439253 IC50 71.0 nM
OCCNc1nc(NCc2nc3c(F)c(F)ccc3[nH]2)c2ncn(-c3cccc(F)c3)c2n1 CHEMBL4215056 IC50 76.0 nM
COc1cc(CC(=O)Nc2nc3ccc(OC(F)(F)F)cc3s2)cc(OC)c1OC CHEMBL3235569 IC50 79.0 nM
OCCCn1cnc(-c2ccc(F)cc2)c1-c1ccncc1 CHEMBL2004871 pKi 79.43 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 79.43 nM
N#Cc1ccc2nc(N)n(-c3nc(-c4ccccc4)cs3)c2c1 CHEMBL1996066 pKi 79.43 nM
Clc1cc2nc(CNc3nc(N4CCNCC4)nc4c3ncn4-c3cccnc3)[nH]c2cc1Cl CHEMBL4209206 IC50 80.0 nM
Cc1ccc(CNc2nc(N3CCOCC3)nc3c2ncn3-c2cccc(F)c2)nc1 CHEMBL4212710 IC50 80.0 nM
Fc1ccc(-c2nn3c(c2-c2ccnc4[nH]ccc24)COCC3)nc1 CHEMBL5431829 IC50 81.0 nM
Cc1ccc2nc(NC(=O)Cc3cccc(Cl)c3)sc2c1 CHEMBL3235535 IC50 83.0 nM
NC(=O)c1sc(-c2ccnc(N)n2)nc1-c1ccc(Cl)cc1Cl CHEMBL3261514 IC50 84.0 nM
Fc1cccc(-n2cnc3c(NCc4ccccn4)nc(N4CCOCC4)nc32)c1 CHEMBL4217233 IC50 85.0 nM
O=C(Cc1cccc(C(F)(F)F)c1)Nc1nc2ccc(C(F)(F)F)cc2s1 CHEMBL3235559 IC50 87.0 nM
Cn1c(-c2cn(-c3cccc(C(=O)O)c3)nn2)nc(-c2ccc(F)cc2)c1-c1ccncc1 CHEMBL3120983 IC50 89.0 nM
Fc1cccc(-n2cnc3c(NCc4ccccc4F)nc(N4CCOCC4)nc32)c1 CHEMBL4208025 IC50 89.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccncc4)c(-c4ccncc4)n3n2)c(-c2ccc(F)cc2)n1 CHEMBL3987018 IC50 97.0 nM
Fc1cccc(-n2cnc3c(NCc4cccnc4)nc(N4CCOCC4)nc32)c1 CHEMBL4212255 IC50 98.0 nM
Cn1c(NCC(N)Cc2ccccc2)nc(-c2ccncc2)c(-c2ccc3ccccc3c2)c1=O CHEMBL1990496 pKi 100.0 nM
Nc1ncnc2c1c(I)nn2C1CCC(O)CC1 CHEMBL1996791 pKi 100.0 nM
O=C(CO)N1CCC(c2[nH]nc(-c3ccc(Cl)cc3F)c2-c2ccncn2)CC1 CHEMBL1614705 pKi 100.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 100.0 nM
Cc1nc(COc2ccccc2Cl)sc1-c1ccnc(N)n1 CHEMBL1375640 pKi 100.0 nM
CN1CCN(c2nc(NCc3nc4cc(Cl)c(Cl)cc4[nH]3)c3ncn(-c4cccnc4)c3n2)CC1 CHEMBL4211678 IC50 100.0 nM
CCN1/C(=C\C(C)=O)Sc2ccc(OC)cc21 CHEMBL1349996 Kd 100.0 nM
COc1ccc(-c2nc(-c3ccnc(N)n3)sc2C(N)=O)c(Cl)c1 CHEMBL3261517 IC50 104.0 nM
CC(C)c1onc(-c2ccc(F)cc2)c1-c1ccnc(NC(=O)Cc2ccc(F)cc2)c1 CHEMBL569151 IC50 110.0 nM
Cc1cc(-c2cnc(Nc3cc(Cl)cc(Cl)c3)nc2NC2CCC(N(C)C)CC2)on1 CHEMBL2312654 IC50 110.0 nM
Cc1ccccc1-n1cnc2c(NCc3nc4c(F)c(F)ccc4[nH]3)nc(N3CCOCC3)nc21 CHEMBL4217142 IC50 110.0 nM
CN1CCN(c2cc(-c3ccncc3)c(-c3ccccc3)nn2)CC1 CHEMBL4639555 IC50 110.0 nM
COc1cnc(CCc2ccc(F)cc2)nc1-c1cc2c([nH]1)CCNC2=O CHEMBL2203554 IC50 112.0 nM
COc1cnc(COc2cc(F)c(F)cc2C)cc1-c1cc2c([nH]1)CCNC2=O CHEMBL2203565 IC50 114.0 nM
Nc1nc2ccc(Br)cc2c2nc(-c3ccco3)nn12 CHEMBL5186013 IC50 120.0 nM
CCCn1c(C2CCNCC2)nc(-c2ccc(Cl)c(Cl)c2)c1-c1ccnc(NC2CCCCC2)n1 CHEMBL437747 pKi 125.89 nM
COC(=O)c1c(-c2ccc(NC(=O)Nc3ccccc3)cc2)c2c(N)ncnn2c1C CHEMBL1977041 pKi 125.89 nM
Fc1ccc(-c2ncn(CCN3CCOCC3)c2-c2ccc3[nH]ncc3c2)cc1 CHEMBL1682558 pKi 125.89 nM
Cc1nccn2c(-c3ccnc(NCC(C)(C)C(=O)O)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1971149 pKi 125.89 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 125.89 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(CN)Cc4ccccc4)c3)cc12 CHEMBL2000271 pKi 125.89 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 125.89 nM
Cn1cc(C=C2C(=O)Nc3cccnc32)c2ccccc21 CHEMBL1516890 pKi 125.89 nM
CC(C)(C)C(=O)Oc1ccc2c(c1)nc(NC(=O)c1cccc([N+](=O)[O-])c1)n2CCCO CHEMBL1236126 pKi 125.89 nM
CN(C)Cc1n[nH]c(-c2ccc3[nH]nc(-c4cccc(C(=O)Nc5ccc(F)cc5)c4)c3c2)n1 CHEMBL3990606 IC50 134.0 nM
Fc1cc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)ccn1 CHEMBL4218717 IC50 145.0 nM
CC(C)(C)n1nc(-c2cccc3ccccc23)c2c(N)ncnc21 CHEMBL264406 IC50 150.0 nM
CCN1/C(=C/C(C)=O)Sc2ccc(OC)cc21 CHEMBL408982 Kd 150.0 nM
O=C1CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4cccc(F)c4)c3n2)CC1 CHEMBL4217426 IC50 150.0 nM
Cc1nc2cc(-c3nn(C(C)C)c4ncnc(N)c34)ccc2o1 CHEMBL3991933 Kd apparent 152.0 nM
Cc1cccc(-c2[nH]c(-c3ccnc(N)n3)cc2C(N)=O)c1C CHEMBL1964290 pKi 158.49 nM
COc1cccc(-c2cc3c(=O)[nH]c4ccccc4n3c2)c1 CHEMBL1991356 pKi 158.49 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)cncc21 CHEMBL1964692 pKi 158.49 nM
Cc1n[nH]c2ccc(-c3cncc(OCCN)c3)cc12 CHEMBL1967887 pKi 158.49 nM
OCCCn1cnc(-c2ccccc2)c1-c1ccncc1 CHEMBL2002373 pKi 158.49 nM
O=C1Nc2ccccc2Nc2nnc(Cl)cc21 CHEMBL1968850 pKi 158.49 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 158.49 nM
CN1CCC(Nc2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4cccc(F)c4)c3n2)CC1 CHEMBL4205719 IC50 160.0 nM
COc1cnc(OCc2ccc(F)cc2)nc1-c1cc2c([nH]1)CCNC2=O CHEMBL2203557 IC50 168.0 nM
NC(=O)c1ccc(-c2nc(-c3ccccn3)c(-c3ccc4c(c3)OCO4)[nH]2)cc1 CHEMBL440084 Kd 170.0 nM
Cc1ccc(-c2nn(C(C)(C)C)c3ncnc(N)c23)cc1 CHEMBL306380 IC50 170.0 nM
NC(=O)c1ccc(-c2nc(-c3ccc4c(c3)OCCO4)c(-c3ccccn3)[nH]2)cc1 CHEMBL410456 IC50 171.0 nM
CN1CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4ccncc4)c3n2)CC1 CHEMBL4218574 IC50 175.0 nM
Fc1cc2nc(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cccnc3)[nH]c2cc1F CHEMBL4205151 IC50 175.0 nM
O=S1(=O)CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4cccc(F)c4)c3n2)CC1 CHEMBL4212734 IC50 175.0 nM
Fc1cccc(-n2cnc3c(NCc4ncc[nH]4)nc(N4CCOCC4)nc32)c1 CHEMBL4215749 IC50 180.0 nM
Nc1nc(NCc2ccccc2)nc2nc(-c3cc(O)cc(O)c3)nn12 CHEMBL4742954 IC50 180.0 nM
Fc1cccc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCSCC4)nc32)c1 CHEMBL4203904 IC50 185.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 188.0 nM
COc1ccc(OC)c(CC(=O)Nc2nc3ccc(C(F)(F)F)cc3s2)c1 CHEMBL3235568 IC50 190.0 nM
Cc1cccc(-c2c(-c3ccncc3)nc(NCC(N)Cc3ccccc3)n(C)c2=O)c1 CHEMBL1971430 pKi 199.53 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(C)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1984162 pKi 199.53 nM
CC(C)Cn1c(N)nc2ccc(-c3c(-c4ccc(F)cc4)nc4sccn34)cc21 CHEMBL1965423 pKi 199.53 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 199.53 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(Cl)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1987054 pKi 199.53 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4cnc5ccccc5c4)c3)cc21 CHEMBL226403 pKi 199.53 nM
CCCCn1c(NC(=O)c2cccc(C#N)c2)nc2cc(N(C)C(=O)C3CCCCC3)ccc21 CHEMBL1969301 pKi 199.53 nM
CN1CCN(c2nc(NCc3nc4cc(F)c(F)cc4[nH]3)c3ncn(-c4cccnc4)c3n2)CC1 CHEMBL4216088 IC50 200.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4CCc3ccoc3)nc2c1F CHEMBL5419193 IC50 200.0 nM
COc1cnc(CCc2ccc(F)cc2)cc1-c1cc2c([nH]1)CCNC2=O CHEMBL2203560 IC50 202.0 nM
Cn1c(-c2c[nH]nn2)nc(-c2ccc(F)cc2)c1-c1ccncc1 CHEMBL3120960 IC50 202.0 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 Kd 210.0 nM
NCCNC(=O)c1cnc(N)n2nc(-c3cc(O)cc(O)c3)nc12 CHEMBL4793727 IC50 210.0 nM
Fc1cccc(-n2cnc3c(NCc4nc(-c5ccccc5)c[nH]4)nc(N4CCOCC4)nc32)c1 CHEMBL4210412 IC50 215.0 nM
Cn1c(-c2cn(CCP(=O)([O-])[O-])nn2)nc(-c2ccc(F)cc2)c1-c1ccncc1 CHEMBL3120985 IC50 225.0 nM
CC(C)c1onc(-c2ccc(F)cc2)c1-c1ccncc1 CHEMBL220227 IC50 230.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3ccccc3C(F)(F)F)nc2c1F CHEMBL4206998 IC50 230.0 nM
COC1CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4cccc(F)c4)c3n2)CC1 CHEMBL4204292 IC50 230.0 nM
CNC(=O)c1nn(C)c2c1C(C)(C)Cc1cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc1-2 CHEMBL564829 Kd apparent 236.0 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 240.0 nM
Cn1c(-c2cn(CCO)nn2)nc(-c2ccc(F)cc2)c1-c1ccncc1 CHEMBL3120963 IC50 240.0 nM
Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12 CHEMBL16687 IC50 240.0 nM
CN1CCN(c2ccc(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cccc(F)c3)cc2)CC1 CHEMBL4203539 IC50 245.0 nM
CCCN(C)c1cc(-c2ccncc2)c(-c2ccccc2)nn1 CHEMBL4648747 IC50 250.0 nM
Cn1cc(-c2ccnc3[nH]c(C(F)(F)F)cc23)c(-c2ccc(F)cn2)n1 CHEMBL5438000 IC50 250.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 251.19 nM
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1970104 pKi 251.19 nM
CNc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3)nc12 CHEMBL2007372 pKi 251.19 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccccc4)c3)cc12 CHEMBL2002726 pKi 251.19 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 251.19 nM
CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 CHEMBL14762 Kd 260.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 260.0 nM
COc1ccccc1CC(=O)Nc1nc2ccc(Br)cc2s1 CHEMBL3235548 IC50 260.0 nM
CN1CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4ccccn4)c3n2)CC1 CHEMBL4214158 IC50 260.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3ccncc3)nc2c1F CHEMBL4206835 IC50 260.0 nM
CN(C)C(=O)c1ccc(N2CCCN(c3ccnc4sc(C(N)=O)c(N)c34)CC2)cc1 CHEMBL2348350 Kd 280.0 nM
c1cc(OCCN2CCCCC2)cc(-c2n[nH]c3ccc(-c4nnc[nH]4)cc23)c1 CHEMBL1614713 Kd apparent 287.0 nM
COc1ccccc1CC(=O)Nc1nc2ccc(C)cc2s1 CHEMBL3235551 IC50 290.0 nM
CN1CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4ccnc(F)c4)c3n2)CC1 CHEMBL4215429 IC50 295.0 nM
Cc1cc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCN(C)CC4)nc32)ccn1 CHEMBL4211128 IC50 295.0 nM
Nc1nc(NCc2ccccc2)cc2nc(-c3cccc(O)c3)nn12 CHEMBL4793501 IC50 300.0 nM
Fc1ccc(-c2nn3c(c2-c2ccnc4[nH]ncc24)CCC(F)(F)C3)nc1 CHEMBL5407201 IC50 300.0 nM
Cc1n[nH]c2cnc(-c3cncc(OCC(N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL1998159 pKi 316.23 nM
NCC(O)C(O)Cn1cc(I)c2c(N)ncnc21 CHEMBL1975534 pKi 316.23 nM
Cc1n[nH]c2c1C(c1ccccc1F)C1=C(CC(C)(C)CC1=O)N2 CHEMBL1966703 pKi 316.23 nM
COCCn1cc(-c2ccncn2)c(-c2ccc(Cl)cc2)n1 CHEMBL1982866 pKi 316.23 nM
Cc1cc(C)c(C=C2C(=O)Nc3ccccc32)[nH]1 CHEMBL2002702 pKi 316.23 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 316.23 nM
Nc1nc2ccc(-c3c(-c4ccc(F)cc4)nc4sccn34)cc2n1CC1CC1 CHEMBL1982874 pKi 316.23 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 316.23 nM
NC(=O)c1cc2c(-c3ccc(F)cc3F)cncc2s1 CHEMBL1975787 pKi 316.23 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 320.0 nM
COc1cc(C)c2nc3[nH]nc(C)c3c(N3CCNCC3)c2c1 CHEMBL1939782 IC50 320.0 nM
COc1ccccc1CC(=O)Nc1nc2ccc(Cl)cc2s1 CHEMBL3235549 IC50 320.0 nM
Fc1cccc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(NCC4CCOCC4)nc32)c1 CHEMBL4213205 IC50 320.0 nM
CN1CCN(c2cc(-c3ccncc3)c(-c3ccc4[nH]ccc4c3)nn2)CC1 CHEMBL4635980 IC50 320.0 nM
CCNC(=O)c1cnc(N)n2nc(-c3cccc(O)c3)nc12 CHEMBL4776464 IC50 320.0 nM
Nc1ccc(N)c2c1C(=O)c1ccccc1C2=O CHEMBL86771 IC50 330.0 nM
O=C(Cc1ccccc1)Nc1nc2ccccc2s1 CHEMBL1405979 IC50 330.0 nM
Cn1cc(-n2cnc3c(NCc4nc5cc(Cl)c(Cl)cc5[nH]4)nc(N4CCOC[C@@H]4CO)nc32)cn1 CHEMBL4849960 IC50 333.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cccnc3)nc2c1F CHEMBL4209644 IC50 335.0 nM
CN1CCN(c2nc(NCc3nc4cc(Cl)ccc4[nH]3)c3ncn(-c4cccnc4)c3n2)CC1 CHEMBL4203354 IC50 335.0 nM
CCN(CC)c1cc(-c2ccncc2)c(-c2ccccc2)nn1 CHEMBL4642101 IC50 340.0 nM
Fc1ccc(-c2nn3c(c2-c2ccnc4[nH]ncc24)COCC3)nc1 CHEMBL5412695 IC50 340.0 nM
CNC(=O)c1ccc2[nH]nc(-c3cccc(C(=O)NCc4cccc5ccccc45)c3)c2c1 CHEMBL4476186 IC50 354.0 nM
Fc1ccc(-c2nn3c(c2-c2ccnc4[nH]ncc24)CCCC3)nc1 CHEMBL5426768 IC50 370.0 nM
O/N=C1/c2ccccc2-c2nc3ccccc3nc21 CHEMBL3393601 Kd 380.0 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 398.11 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(N)=O CHEMBL485556 pKi 398.11 nM
CC(C)n1nnc2ccc(-c3c(-c4ccc(F)cc4F)nc4occn34)cc21 CHEMBL1969126 pKi 398.11 nM
O=C(Nc1nc2ccccc2n1CCCO)c1cccc([N+](=O)[O-])c1 CHEMBL210887 pKi 398.11 nM
Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2C1CCC(N2CCCC2)CC1 CHEMBL1965910 pKi 398.11 nM
NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(-c3ccncc3)ccc2c1=O CHEMBL340384 pKi 398.11 nM
NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL590109 pKi 398.11 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 398.11 nM
CC1CCC(c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)CC1 CHEMBL523938 IC50 400.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3nccs3)nc2c1F CHEMBL4856935 IC50 400.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cc4ccccc4s3)nc2c1F CHEMBL5413697 IC50 400.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cncs3)nc2c1F CHEMBL4849684 IC50 419.0 nM
COc1cccc(CC(=O)Nc2nc3ccc(OC)cc3s2)c1 CHEMBL3235557 IC50 420.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4CCc3ccsc3)nc2c1F CHEMBL5414012 IC50 420.0 nM
O=C(CC1CCCCC1)Nc1nc2ccc(C(F)(F)F)cc2s1 CHEMBL3235573 IC50 430.0 nM
Clc1ccc2[nH]c(CNc3nc(N4CCNCC4)nc4c3ncn4-c3cccnc3)nc2c1 CHEMBL4205502 IC50 430.0 nM
Nc1nc2ccc(Cl)cc2c2nc(-c3ncco3)nn12 CHEMBL5182545 IC50 430.0 nM
COc1ncc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)cn1 CHEMBL3898566 IC50 435.0 nM
Cn1c(-c2cn([C@H]3CCNC[C@@H]3F)nn2)nc(-c2ccc(F)cc2)c1-c1ccncc1 CHEMBL3120986 IC50 437.0 nM
Cn1c(-c2cn([C@@H]3[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]3O)nn2)nc(-c2ccc(F)cc2)c1-c1ccncc1 CHEMBL3314270 IC50 439.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3ccccn3)nc2c1F CHEMBL4202470 IC50 440.0 nM
Fc1ccc(CCn2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)cc1 CHEMBL5435094 IC50 440.0 nM
CC(C)(C)CC(=O)Nc1nc2ccc(C(F)(F)F)cc2s1 CHEMBL3235574 IC50 460.0 nM
Nc1nc(NCc2ccccc2)nc2nc(-c3cccc(O)c3)nn12 CHEMBL4760165 IC50 460.0 nM
Nc1nc(NCc2ccc(F)cc2)nc2nc(-c3cc(O)cc(O)c3)nn12 CHEMBL4784755 IC50 470.0 nM
CCOC(=O)c1cnc(N)n2nc(-c3cc(O)cc(O)c3)nc12 CHEMBL4752690 IC50 480.0 nM
NC(COc1cncc(-c2cc3cnccc3s2)c1)Cc1c[nH]c2ccccc12 CHEMBL1972840 pKi 501.19 nM
O=c1cc(-c2ccncc2)nc(NC2CCCCC2)[nH]1 CHEMBL1958401 pKi 501.19 nM
NC(=O)c1sc2ccc(Cl)c(Cl)c2c1NC(=O)c1ccc(Cl)cc1 CHEMBL2003271 pKi 501.19 nM
Nc1ncc(-c2ccoc2)c2scc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c12 CHEMBL1965570 pKi 501.19 nM
O=C1Nc2ccccc2Nc2nnccc21 CHEMBL1971801 pKi 501.19 nM
NC(=O)c1cc2c(-c3ccccc3)cncc2s1 CHEMBL1999556 pKi 501.19 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 CHEMBL4793380 IC50 509.0 nM
Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 CHEMBL1240885 IC50 510.0 nM
Clc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cccnc3)nc2c1 CHEMBL4205223 IC50 520.0 nM
COc1ccc2nc(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cccnc3)[nH]c2c1 CHEMBL4213254 IC50 520.0 nM
Fc1ccc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)c(F)c1 CHEMBL4208642 IC50 525.0 nM
COc1ccc2nc(NC(=O)Cc3cccc(Cl)c3)sc2c1 CHEMBL3235539 IC50 530.0 nM
Cc1cccc(CNc2nc(N)n3nc(-c4cc(O)cc(O)c4)nc3n2)c1 CHEMBL4745216 IC50 530.0 nM
Fc1ccc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)cc1 CHEMBL4213060 IC50 535.0 nM
O=C(Cc1cccc(Cl)c1)Nc1nc2ccc(OC(F)(F)F)cc2s1 CHEMBL3235540 IC50 540.0 nM
O=C(O/N=C1/c2ccccc2-c2nc3ccccc3nc21)c1ccco1 CHEMBL3393602 Kd 560.0 nM
COc1ccc(CC(=O)Nc2nc3ccc(OC)cc3s2)cc1 CHEMBL3235561 IC50 570.0 nM
O=C(Cc1ccc(Cl)c(Cl)c1)Nc1nc2ccc(OC(F)(F)F)cc2s1 CHEMBL3235567 IC50 590.0 nM
COc1ccc2nc(CNc3nc(N4CCN(C)CC4)nc4c3ncn4-c3cccnc3)[nH]c2c1 CHEMBL4216393 IC50 610.0 nM
COc1ccccc1CC(=O)Nc1nc2ccc(OC(F)(F)F)cc2s1 CHEMBL3235554 IC50 620.0 nM
CNC1CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4cccc(F)c4)c3n2)CC1 CHEMBL4210085 IC50 620.0 nM
COc1ccc2nc(CNc3nc(N4CCNCC4)nc4c3ncn4-c3cccnc3)[nH]c2c1 CHEMBL4213833 IC50 625.0 nM
NC(=O)c1cccc2c1Nc1nnc(Cl)cc1C(=O)N2 CHEMBL1968070 pKi 630.96 nM
NC(=O)c1sc2c(Br)ccc(Cl)c2c1N CHEMBL1998611 pKi 630.96 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCCC4=O)c3)n2)c1 CHEMBL1991429 pKi 630.96 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCOCC4)c3)n2)c1 CHEMBL1090360 pKi 630.96 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cncc4c3c(N)nn4C)cc2)c1 CHEMBL404367 pKi 630.96 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 630.96 nM
NC(=O)c1cc2c(-c3cccc(F)c3)cncc2s1 CHEMBL1971017 pKi 630.96 nM
O=c1nc(-c2ccc3[nH]ncc3c2)cc(-c2ccccc2)[nH]1 CHEMBL526133 pKi 630.96 nM
CCCCOc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1996817 pKi 630.96 nM
Nc1ncc(-c2ccncc2)c2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1970083 pKi 630.96 nM
Nc1ccc(O)c2c1C(=O)c1ccccc1C2=O CHEMBL88326 IC50 660.0 nM
Nc1nc(NC2CCCCC2)nc2nc(-c3cc(O)cc(O)c3)nn12 CHEMBL4782184 IC50 670.0 nM
Nc1nc2c([nH]1)c1c(c3[nH]c(N)nc32)[C@H](CNC(=O)c2[nH]cc(Br)c2Br)[C@H]1CNC(=O)c1[nH]cc(Br)c1Br CHEMBL4780812 IC50 680.0 nM
COc1cc(OC)c(/C=C2\C(=O)Nc3ccccc32)c(OC)c1 CHEMBL404941 IC50 700.0 nM
CC(=O)Nc1cc(-c2c(-c3ccc(F)cc3)noc2C(C)C)ccn1 CHEMBL585533 IC50 700.0 nM
CN1CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4cccnc4)c3n2)CC1 CHEMBL4209759 IC50 700.0 nM
CN(C)c1cc(-c2ccncc2)c(-c2ccccc2)nn1 CHEMBL4645737 IC50 710.0 nM
Nc1nc(NCc2ccccc2)cc2nc(-c3cc(O)cc(O)c3)nn12 CHEMBL4795601 IC50 740.0 nM
COc1ccc2nc(NC(=O)Cc3ccc(Cl)cc3)sc2c1 CHEMBL3235546 IC50 750.0 nM
Nc1nc(NCc2ccc(Cl)cc2)nc2nc(-c3cc(O)cc(O)c3)nn12 CHEMBL4793180 IC50 750.0 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 794.33 nM
CC(N)COc1cnc(Cl)c(C=Cc2ccncc2)c1 CHEMBL1993548 pKi 794.33 nM
CSc1cnc2c(ccc3cnccc32)c1O CHEMBL2006933 pKi 794.33 nM
CC(C)(O)c1nnc2ccc(-c3c(-c4ccc(F)cc4F)nc4n3CCC4)nn12 CHEMBL1998551 pKi 794.33 nM
O=C1Nc2ccccc2Nc2nnc(I)cc21 CHEMBL1977346 pKi 794.33 nM
CCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccc(C(=O)Nc6ccccc6F)c5)nc5ccccn45)n3)cc2)CC1 CHEMBL1981725 pKi 794.33 nM
c1cnc2nc(-c3ccc4[nH]ncc4c3)c(NC3CCCCC3)n2c1 CHEMBL1682552 pKi 794.33 nM
O=C(O)c1cc2c(-c3ccccc3)cncc2s1 CHEMBL1996390 pKi 794.33 nM
CC(C)Cn1c(N)nc2c(F)cc(-c3c(-c4ccc(F)cc4)nc4sccn34)cc21 CHEMBL2004419 pKi 794.33 nM
Cc1ccc(Nc2nc3ccc([N+](=O)[O-])cc3[nH]2)nc1 CHEMBL1992937 pKi 794.33 nM
NC(COc1cncc(-c2cc3ccncc3s2)c1)Cc1c[nH]c2ccccc12 CHEMBL1966524 pKi 794.33 nM
CSc1nn(-c2ccccn2)c(N)c1C(N)=O CHEMBL2004615 pKi 794.33 nM
CC(Oc1ccccc1)C(=O)Nc1cc(-c2c(-c3ccc(F)cc3)noc2C(C)C)ccn1 CHEMBL566058 IC50 820.0 nM
c1cncc(-n2cnc3c(NCc4nc5ccccc5[nH]4)nc(N4CCNCC4)nc32)c1 CHEMBL4216210 IC50 825.0 nM
Fc1cccc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(NCCN4CCOCC4)nc32)c1 CHEMBL4212477 IC50 830.0 nM
Fc1ccc(-c2n[nH]c3ccc(-c4n[nH]c(CN5CCCC5)n4)cc23)cc1 CHEMBL3940534 IC50 848.0 nM
O=C(Cc1cccc(Cl)c1)Nc1nc2ccccc2s1 CHEMBL3235183 IC50 850.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cscn3)nc2c1F CHEMBL4868958 IC50 870.0 nM
Cn1cc(-c2ccc3nc(Nc4ncccn4)c(Br)n3n2)c(-c2ccc(F)cc2)n1 CHEMBL3925264 IC50 871.0 nM
Nc1nc(NCc2ccccc2)nc2nc(-c3ccc(O)c(O)c3)nn12 CHEMBL4783829 IC50 910.0 nM
Fc1cccc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(NCCCN4CCOCC4)nc32)c1 CHEMBL4210748 IC50 915.0 nM
CCOc1ccc2nc(NC(=O)Cc3cccc(OC)c3)sc2c1 CHEMBL3235558 IC50 990.0 nM
CCNC(=O)c1cnc(N)n2nc(-c3cc(O)cc(O)c3)nc12 CHEMBL4761245 IC50 990.0 nM
COc1cc(OC)c(C=C2C(=O)Nc3ccccc32)c(OC)c1 CHEMBL576349 IC50 1000.0 nM
CC(=O)Nc1c(C(N)=O)sc2ccc(Cl)c(Cl)c12 CHEMBL1973142 pKi 1000.0 nM
CSc1c[nH]c2ncnc(NCCCO)c12 CHEMBL2000114 pKi 1000.0 nM
NC(=O)c1cc2c(-c3ccc(Br)c(F)c3F)cncc2s1 CHEMBL1999918 pKi 1000.0 nM
Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2C1CC(CN2CCCC2)C1 CHEMBL1988370 pKi 1000.0 nM
COc1cc(C=C2SC(=Nc3ccccc3)NC2=O)ccc1O CHEMBL1970522 pKi 1000.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cncc4c3c(N)nn4C)cc2)c1 CHEMBL402846 pKi 1000.0 nM
Nc1ccc(-c2csc3c(C=Cc4nc5ccccc5[nH]4)cnc(N)c23)cc1 CHEMBL1988300 pKi 1000.0 nM
COc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1OC CHEMBL1991078 pKi 1000.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 1000.0 nM
c1cnc2nc(-c3ccc4[nH]ncc4c3)cn2c1 CHEMBL1682540 pKi 1000.0 nM
Cn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC3CCOCC3)nc21 CHEMBL1230122 pKi 1000.0 nM
NCC(NC(=O)c1ccc(-c2ccncc2)cc1)c1ccccc1 CHEMBL1990254 pKi 1000.0 nM
Nc1ncnc2c1c(I)nn2C1OC(CO)C(O)C1O CHEMBL2001288 pKi 1000.0 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4ccccc4F)c3)cc21 CHEMBL226471 pKi 1000.0 nM
COc1cc(OC)c(/C=C2/C(=O)Nc3ccccc32)c(OC)c1 CHEMBL489156 IC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM