Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(C(=O)CN)CC1 CHEMBL3962177 IC50 0.2 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(C(=O)c2cncs2)CC1 CHEMBL3978116 IC50 0.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(C[C@@H](O)C(F)(F)F)CC1 CHEMBL4108038 IC50 0.3 nM
Cc1nc(-c2cccnc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCN(Cc4ccon4)CC3)ccc2n1 CHEMBL3912884 IC50 0.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1C1CCN(CC(N)=O)CC1 CHEMBL3944464 IC50 0.6 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCN(Cc2ccon2)CC1 CHEMBL3981677 IC50 0.8 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCN(Cc4ccon4)CC3)ccc2n1 CHEMBL3910319 IC50 0.9 nM
CC1(O)CCC(NC(=O)N2CCn3c(Cl)c(-c4cccc(F)c4)c(C(N)=O)c3C2)CC1 CHEMBL3921967 IC50 1.0 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(Cc2ccon2)CC1 CHEMBL3902265 IC50 1.0 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1C1CCNCC1 CHEMBL3902838 IC50 1.0 nM
Fc1ccc(-c2nc3ccc(N4CCC(N5CCCC5)CC4)nn3c2-c2ccncc2)cc1 CHEMBL4483506 IC50 1.0 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCN(CC(N)=O)CC3)ccc2n1 CHEMBL3981952 IC50 1.2 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(CC(N)=O)CC1 CHEMBL3939027 IC50 1.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(CC(N)=O)CC1 CHEMBL3922511 IC50 1.3 nM
Cc1nc(-c2cccnc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCN(CC(N)=O)CC3)ccc2n1 CHEMBL3900391 IC50 1.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(C[C@H](O)C(F)(F)F)CC1 CHEMBL3894506 IC50 1.4 nM
CSc1ccc(-c2c(C(N)=O)c3n(c2C2CC2)CCN(C(=O)NC(C)(C)C)C3)cc1 CHEMBL3982382 IC50 1.5 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCN(CCO)CC1 CHEMBL3895083 IC50 1.5 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCNCC3)ccc2n1 CHEMBL3957543 IC50 1.5 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(CCO)CC1 CHEMBL3961316 IC50 1.8 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1N1CCNCC1 CHEMBL3907925 IC50 1.8 nM
Cc1nc(-c2cccnc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCNCC3)ccc2n1 CHEMBL3893731 IC50 1.8 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCOCC1 CHEMBL3910924 IC50 1.8 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCN(C2CC2)CC1 CHEMBL3922012 IC50 1.9 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4cccc(-c5cccnc5)c4)cn3n2)c1C1CCOCC1 CHEMBL3932533 IC50 1.9 nM
COc1ccc(-c2c(C(N)=O)c3n(c2C)CCN(C(=O)NC(C)(C)C)C3)cc1 CHEMBL3940253 IC50 2.0 nM
COc1cccc(-c2c(C(N)=O)c3n(c2Cl)CCN(C(=O)NC(C)(C)C)C3)c1 CHEMBL3980827 IC50 2.0 nM
COc1ccc(-c2c(C(N)=O)c3n(c2Cl)CCN(C(=O)NC(C)(C)C)C3)cc1 CHEMBL3906666 IC50 2.0 nM
CC(C)(NC(=O)N1CCn2c(Cl)c(-c3cccc(F)c3)c(C(N)=O)c2C1)C(F)(F)F CHEMBL3930764 IC50 2.0 nM
NC(=O)c1c(-c2cccc(F)c2)c(Cl)n2c1CN(C(=O)NC1CCC(O)(C(F)(F)F)CC1)CC2 CHEMBL3899331 IC50 2.0 nM
NC(=O)c1c(-c2cccc(F)c2)c(Cl)n2c1CN(C(=O)NC1CCC(F)(F)CC1)CC2 CHEMBL3966265 IC50 2.0 nM
CC(NC(=O)N1CCn2c(C#N)c(-c3cccc(F)c3)c(C(N)=O)c2C1)C(F)(F)F CHEMBL3916620 IC50 2.0 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCOCC1 CHEMBL3926405 IC50 2.0 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N)c4)cn3n2)c1N1CCN(Cc2ccon2)CC1 CHEMBL3971152 IC50 2.2 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(C(=O)c2ccon2)CC1 CHEMBL3915816 IC50 2.2 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCNCC1 CHEMBL3913933 IC50 2.3 nM
Cc1nc(-c2cccnc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCOCC3)ccc2n1 CHEMBL3986585 IC50 2.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N)c4)cn3n2)c1N1CCNCC1 CHEMBL3936095 IC50 2.4 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCN(CCC#N)CC3)ccc2n1 CHEMBL3947732 IC50 2.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(CCC#N)CC1 CHEMBL3942825 IC50 2.6 nM
COCC(=O)N1CCC(c2c(-c3ccc4nc(NC(=O)c5ccnc(F)c5)cn4n3)c(-c3ccc(F)cc3)nn2C)CC1 CHEMBL3943491 IC50 2.7 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc(-c4ccccc4)cc3)c2C2CC2)C1 CHEMBL3904940 IC50 3.0 nM
CC(C)(C)NC(=O)N1CCn2c(Cl)c(-c3cccc(F)c3)c(C(N)=O)c2C1 CHEMBL3934271 IC50 3.0 nM
CC(NC(=O)N1CCn2c(Cl)c(-c3cccc(F)c3)c(C(N)=O)c2C1)C(F)(F)F CHEMBL3983892 IC50 3.0 nM
NC(=O)c1c(-c2cccc(F)c2)c(Cl)n2c1CN(C(=O)N[C@H]1CC[C@H](O)CC1)CC2 CHEMBL3943616 IC50 3.0 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCOCC3)ccc2n1 CHEMBL3906580 IC50 3.0 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1N1CCN(Cc2ccon2)CC1 CHEMBL3935382 IC50 3.1 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1-c1ccncc1 CHEMBL3948521 IC50 3.2 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1N1CCNCC1 CHEMBL3889846 IC50 3.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCNCC1 CHEMBL3916526 IC50 3.3 nM
COc1cc(C(=O)Nc2cn3nc(-c4c(-c5ccc(F)cc5)nn(C)c4N4CCNCC4)ccc3n2)ccn1 CHEMBL3933835 IC50 3.6 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCOCC1 CHEMBL3952882 IC50 3.7 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(Cc2ccon2)CC1 CHEMBL3926825 IC50 3.9 nM
Cc1cccc(-c2c(C(N)=O)c3n(c2C2CC2)CCN(C(=O)NC(C)(C)C)C3)c1 CHEMBL3919427 IC50 4.0 nM
CN(C)c1ccc(-c2c(C(N)=O)c3n(c2C2CC2)CCN(C(=O)NC(C)(C)C)C3)cc1 CHEMBL4111304 IC50 4.0 nM
COc1cccc(-c2c(C(N)=O)c3n(c2C2CC2)CCN(C(=O)NC(C)(C)C)C3)c1 CHEMBL3946837 IC50 4.0 nM
COc1ccc(-c2c(C(N)=O)c3n(c2C2CC2)CCN(C(=O)NCC24CC5CC(CC(C5)C2)C4)C3)cc1 CHEMBL3928822 IC50 4.0 nM
Cc1cccc(-c2c(C(N)=O)c3n(c2Cl)CCN(C(=O)NC(C)(C)C)C3)c1 CHEMBL3897060 IC50 4.0 nM
CC(C)(C)NC(=O)N1CCn2c(Cl)c(-c3cccc(C(F)(F)F)c3)c(C(N)=O)c2C1 CHEMBL3972809 IC50 4.0 nM
CC(C)(C)CNC(=O)N1CCn2c(Cl)c(-c3ccccc3)c(C(N)=O)c2C1 CHEMBL3915776 IC50 4.0 nM
CCC(CC)CNC(=O)N1CCn2c(Cl)c(-c3ccccc3)c(C(N)=O)c2C1 CHEMBL3962841 IC50 4.0 nM
NC(=O)c1c(-c2cccc(F)c2)c(Cl)n2c1CN(C(=O)NCC1(CO)CC1)CC2 CHEMBL3948816 IC50 4.0 nM
NC(=O)c1c(-c2ccccc2)c(Cl)n2c1CN(C(=O)NC1CCCCC1)CC2 CHEMBL3916209 IC50 4.0 nM
NC(=O)c1c(-c2ccccc2)c(Cl)n2c1CN(C(=O)NC13C=CC(CC1)C3)CC2 CHEMBL3936473 IC50 4.0 nM
CC1(CNC(=O)N2CCn3c(Cl)c(-c4cccc(F)c4)c(C(N)=O)c3C2)COC1 CHEMBL3974772 IC50 4.0 nM
CC1(C)CC(NC(=O)N2CCn3c(Cl)c(-c4cccc(F)c4)c(C(N)=O)c3C2)CCO1 CHEMBL3893126 IC50 4.0 nM
N#Cc1c(-c2cccc(F)c2)c(C(N)=O)c2n1CCN(C(=O)NCCCC(F)(F)F)C2 CHEMBL3892730 IC50 4.0 nM
Cc1nc(-c2cccnc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCN(C)CC3)ccc2n1 CHEMBL3982756 IC50 4.0 nM
Cn1ncc(-c2nc(N[C@H]3CC[C@H](N)CC3)ncc2Cl)c1CC1CC1 CHEMBL4754493 IC50 4.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(CCC#N)CC1 CHEMBL3953610 IC50 4.6 nM
CC1(C)CN(c2ccc3nc(-c4ccccc4)c(-c4ccncc4)n3n2)CCN1 CHEMBL4435154 IC50 4.6 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cncc(O)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3959158 IC50 4.7 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3907142 IC50 4.8 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1C1CCOCC1 CHEMBL3938867 IC50 4.8 nM
Cc1nc(-c2cccnc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3N3CCOCC3)ccc2n1 CHEMBL3893281 IC50 4.9 nM
CC(C)CCNC(=O)N1CCn2c(Cl)c(-c3ccccc3)c(C(N)=O)c2C1 CHEMBL3944316 IC50 5.0 nM
NC(=O)c1c(-c2cccc(F)c2)c(Cl)n2c1CN(C(=O)NCC(F)(F)F)CC2 CHEMBL3981110 IC50 5.0 nM
CN1CCC(c2c(-c3ccc4nc(NC(=O)c5ccncc5)cn4n3)c(-c3ccc(F)cc3)nn2C)CC1 CHEMBL3925387 IC50 5.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccccc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3958671 IC50 5.6 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(C(=O)CC(F)(F)F)CC1 CHEMBL3895318 IC50 5.7 nM
NC(=O)c1c(-c2ccccc2)c(C2CC2)n2c1CN(C(=O)NCC13CC4CC(CC(C4)C1)C3)CC2 CHEMBL3956390 IC50 6.0 nM
CC(C)(CO)CNC(=O)N1CCn2c(Cl)c(-c3cccc(F)c3)c(C(N)=O)c2C1 CHEMBL3920293 IC50 6.0 nM
CC(C)(CO)CNC(=O)N1CCn2c(Cl)c(-c3cccc(C(F)(F)F)c3)c(C(N)=O)c2C1 CHEMBL3962278 IC50 6.0 nM
NC(=O)c1c(-c2cccc(F)c2)c(Cl)n2c1CN(C(=O)NC1COC1)CC2 CHEMBL3948801 IC50 6.0 nM
N#Cc1cccc(-c2c(C(N)=O)c3n(c2Cl)CCN(C(=O)NC2CCOCC2)C3)c1 CHEMBL3969316 IC50 6.0 nM
Cn1cc(-c2ccc3nc(NC(=O)C45CC6CC(CC(C6)C4)C5)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3924829 IC50 6.0 nM
Cn1cc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)cn1 CHEMBL3977481 IC50 6.1 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(C[C@@H](O)C(F)(F)F)CC1 CHEMBL4107936 IC50 6.2 nM
CCN(CC)Cc1ccc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)cc1 CHEMBL3930043 IC50 6.3 nM
Cc1ccncc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3941604 IC50 6.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCN(Cc2nccs2)CC1 CHEMBL3890290 IC50 6.4 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cncs4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3892824 IC50 6.6 nM
CN(C)c1ccc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)cn1 CHEMBL3953061 IC50 6.6 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1N1CCN(C(=O)CC(F)(F)F)CC1 CHEMBL3950183 IC50 6.7 nM
COc1cc(F)cc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)c1 CHEMBL3935757 IC50 6.8 nM
COc1ccc(-c2c(C(N)=O)c3n(c2C2CC2)CCN(C(=O)NCC24CC5CC(CC2C5)C4)C3)cc1 CHEMBL3967471 IC50 7.0 nM
CC(C)(C)NC(=O)N1CCn2c(Cl)c(-c3ccccc3)c(C(N)=O)c2C1 CHEMBL3936177 IC50 7.0 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCN(C)CC3)ccc2n1 CHEMBL3933511 IC50 7.1 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3940237 IC50 7.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(CCCF)CC1 CHEMBL3931942 IC50 7.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCN(Cc2cc[nH]n2)CC1 CHEMBL3903876 IC50 7.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCN(C2CCOCC2)CC1 CHEMBL3923060 IC50 7.7 nM
Nc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCCCC2)n1 CHEMBL1951415 IC50 7.7 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(CN5CCCC5)cc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3941685 IC50 7.9 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3N3CCOCC3)ccc2n1 CHEMBL3947948 IC50 7.9 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1-c1ccncc1 CHEMBL3921603 IC50 7.9 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3cccc(F)c3)c2C2CC2)C1 CHEMBL3951263 IC50 8.0 nM
NC(=O)c1c(-c2cccc(F)c2)c(Cl)n2c1CN(C(=O)NC1CCS(=O)(=O)C1)CC2 CHEMBL3925634 IC50 8.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cccc(-c5cccnc5)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3940555 IC50 8.1 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1N1CCN(C(=O)c2ccon2)CC1 CHEMBL3932369 IC50 8.1 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1-c1ccncc1 CHEMBL3916656 IC50 8.1 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cnc(C(F)(F)F)nc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3969763 IC50 8.3 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cccc(F)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3946336 IC50 8.6 nM
Cc1cc(C)cc(-c2nc3ccc(N4CCNC(C)(C)C4)nn3c2-c2ccncc2)c1 CHEMBL4451101 IC50 8.6 nM
CC(C)(C)CCNC(=O)N1CCn2c(Cl)c(-c3ccccc3)c(C(N)=O)c2C1 CHEMBL3902843 IC50 9.0 nM
NC(=O)c1c(-c2cccc(F)c2)c(Cl)n2c1CN(C(=O)NCCC(F)(F)F)CC2 CHEMBL3955263 IC50 9.0 nM
NC(=O)c1c(-c2cccc(F)c2)c(Cl)n2c1CN(C(=O)NCCCC(F)(F)F)CC2 CHEMBL3958242 IC50 9.0 nM
NC(=O)c1c(-c2cccc(F)c2)c(Cl)n2c1CN(C(=O)NC1CCOCC1)CC2 CHEMBL3969732 IC50 9.0 nM
N#Cc1c(-c2cccc(F)c2)c(C(N)=O)c2n1CCN(C(=O)NC1CCOCC1)C2 CHEMBL3953021 IC50 9.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccncc4F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3981324 IC50 9.1 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccccc4F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3929204 IC50 9.2 nM
CN1CCN(c2c(-c3ccc4nc(NC(=O)c5ccnc(F)c5)cn4n3)c(-c3ccc(F)cc3)nn2C)CC1 CHEMBL3903967 IC50 9.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1N1CCN(C(=O)CC(F)(F)F)CC1 CHEMBL3922374 IC50 9.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1N1CCN(CCCF)CC1 CHEMBL3905231 IC50 9.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4cccc(-c5cccnc5)c4)cn3n2)c1-c1ccncc1 CHEMBL3976515 IC50 9.8 nM
O=C(Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1)c1ccncc1 CHEMBL3967723 IC50 9.9 nM
NC(=O)c1c(-c2ccccc2)c(Cl)n2c1CN(C(=O)NCC1CC1)CC2 CHEMBL3919924 IC50 10.0 nM
Cc1cccc(-c2c(C(N)=O)c3n(c2Cl)CCN(C(=O)NC2CCOCC2)C3)c1 CHEMBL3907568 IC50 10.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cccnc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3903330 IC50 10.1 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(CCCF)CC1 CHEMBL3936532 IC50 10.1 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1N1CCN(C(=O)c2ccon2)CC1 CHEMBL3893406 IC50 10.1 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cncc(Cl)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3905181 IC50 10.2 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCN(Cc2cocn2)CC1 CHEMBL3899096 IC50 10.4 nM
Cn1cc(-c2ccc3nc(NC(=O)C4CCCCCC4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3917728 IC50 10.5 nM
Cn1cc(-c2ccc3nc(NC(=O)C45CCCC(CCC4)C5)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3902286 IC50 10.5 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1C1CCN(CCC(F)(F)F)CC1 CHEMBL3939036 IC50 10.5 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(C[C@H](O)C(F)(F)F)CC1 CHEMBL3889600 IC50 10.6 nM
CC(C)CNC(=O)N1CCn2c(Cl)c(-c3ccccc3)c(C(N)=O)c2C1 CHEMBL3948277 IC50 11.0 nM
NC(=O)c1c(-c2cccc(F)c2)c(Cl)n2c1CN(C(=O)NC1CCS(=O)(=O)CC1)CC2 CHEMBL3941097 IC50 11.0 nM
Cc1ncccc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3982144 IC50 11.0 nM
Cn1cc(-c2ccc3nc(NC(=O)C4CCCCC4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3889723 IC50 11.3 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(CO)cc4F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3900216 IC50 11.5 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1C1CCN(Cc2cscn2)CC1 CHEMBL3970297 IC50 11.7 nM
Cc1ccc(-c2c(C(N)=O)c3n(c2C2CC2)CCN(C(=O)NC(C)(C)C)C3)cc1 CHEMBL3941915 IC50 12.0 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccccc3F)c2C2CC2)C1 CHEMBL3940078 IC50 12.0 nM
NC(=O)c1c(-c2ccccc2)c(Cl)n2c1CN(C(=O)NC1CCOC1)CC2 CHEMBL3955204 IC50 12.0 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1N1CCN(Cc2ccon2)CC1 CHEMBL3951296 IC50 12.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(C#N)ccc4F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3910402 IC50 12.1 nM
Cc1nc(-c2cccnc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCN(CCC(F)(F)F)CC3)ccc2n1 CHEMBL3974768 IC50 12.2 nM
Cc1nc(-c2cccnc2)sc1C(=O)Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3900211 IC50 12.3 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 13.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cnn(C)c4Cl)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3932365 IC50 13.1 nM
COc1cccc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)n1 CHEMBL3946925 IC50 13.3 nM
COc1cc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)ccn1 CHEMBL3978386 IC50 13.6 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3986343 IC50 13.7 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ncccc4Cl)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3914746 IC50 13.7 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(Br)cc4F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3974872 IC50 13.7 nM
C[C@H]1CN(c2ccc3nc(-c4ccccc4)c(-c4ccncc4)n3n2)CCN1 CHEMBL4476155 IC50 13.7 nM
Cn1cc(-c2ccc3nc(NC(=O)C4CC5CC46CC56)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3930261 IC50 13.8 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3925884 IC50 14.0 nM
O=C(Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1)c1ccncc1F CHEMBL3952116 IC50 14.0 nM
C[C@H]1CN(c2ccc3nc(-c4ccc(F)cc4)c(-c4ccncc4)n3n2)CCN1 CHEMBL4536777 IC50 14.2 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3c(-c4ccc(F)cc4)nn(C)c3C3CCN(CCC(F)(F)F)CC3)ccc2n1 CHEMBL3981157 IC50 14.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(C(=O)CC(F)(F)F)CC1 CHEMBL3909877 IC50 14.4 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccnnc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3959875 IC50 14.5 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccccc4)c(C#N)n3n2)c(-c2ccc(F)cc2)n1 CHEMBL3904017 IC50 14.5 nM
CC1(C)CN(c2ccc3nc(-c4ccc(F)cc4)c(-c4ccncc4)n3n2)CCN1 CHEMBL4533527 IC50 14.6 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccno4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3909525 IC50 15.2 nM
O=C(Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1)c1ccnc(F)c1 CHEMBL3960818 IC50 15.2 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(F)nc(F)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3949881 IC50 15.4 nM
Cn1cc(-c2ccc3nc(NC(=O)C4CCCC4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3907589 IC50 15.7 nM
Fc1ccc(-c2nc3ccc(N4CC5CC4CN5)nn3c2-c2ccncc2)cc1 CHEMBL4435362 IC50 15.7 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(F)cc(F)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3943891 IC50 15.8 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc(OCc4ccc(F)cc4)c(Cl)c3)c2C2CC2)C1 CHEMBL3891930 IC50 16.0 nM
Fc1ccc(F)c(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)c1 CHEMBL4214571 IC50 16.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(Cl)cc4F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3972305 IC50 16.2 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc(-n4cccn4)cc3)c2C2CC2)C1 CHEMBL3976253 IC50 17.0 nM
CC(C)(C)NC(=O)N1CCn2c(F)c(-c3ccccc3)c(C(N)=O)c2C1 CHEMBL3980570 IC50 17.0 nM
NC(=O)c1c(-c2ccccc2)c(Cl)n2c1CN(C(=O)NC1CCS(=O)(=O)C1)CC2 CHEMBL3953252 IC50 17.0 nM
Nc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCN(Cc3ccon3)CC2)n1 CHEMBL4128865 IC50 17.0 nM
Cc1nc(C(F)(F)F)ccc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3915828 IC50 17.2 nM
Cc1nc(-c2ccccn2)sc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3951515 IC50 17.3 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(-n5cccn5)nc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3932627 IC50 17.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1C1CCN(CCCF)CC1 CHEMBL3915283 IC50 17.5 nM
Cc1nc(-c2cccnc2)sc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3954265 IC50 17.8 nM
Cc1cc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)ccn1 CHEMBL3916882 IC50 17.8 nM
NC(=O)c1c(-c2ccccc2)c(Cl)n2c1CN(C(=O)NCC(F)(F)F)CC2 CHEMBL3954102 IC50 18.0 nM
Cn1cc(-c2ccc3nc(NC(=O)C4CCOCC4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3982877 IC50 18.0 nM
COCCN1CCN(c2c(-c3ccc4nc(NC(=O)c5ccnc(F)c5)cn4n3)c(-c3ccc(F)cc3)nn2C)CC1 CHEMBL3909456 IC50 18.6 nM
Cc1c[nH]nc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3927972 IC50 18.7 nM
COc1c(F)cc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)cc1F CHEMBL3940974 IC50 18.7 nM
NC(=O)c1c(-c2cccc(C(F)(F)F)c2)c(Cl)n2c1CN(C(=O)NC1CCOCC1)CC2 CHEMBL3981134 IC50 19.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(Cl)nc5ccccc45)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3899562 IC50 19.2 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(Cl)ccc4F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3896785 IC50 19.9 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)c2C2CC2)C1 CHEMBL3959773 IC50 20.0 nM
CN(C)Cc1cccc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)c1 CHEMBL3975103 IC50 20.0 nM
COc1ccc(F)c(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)c1 CHEMBL3969708 IC50 21.2 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(C#N)nc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3960227 IC50 21.4 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cccc(N5CCOCC5)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3949364 IC50 22.0 nM
COc1cccc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)c1F CHEMBL3963771 IC50 22.1 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(F)cc(C#N)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3963299 IC50 22.3 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4cc(F)nc(F)c4)cn3n2)c1N1CCOCC1 CHEMBL3909742 IC50 22.8 nM
Cn1cc(-c2ccc3nc(NC(=O)c4csc(Br)n4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3972492 IC50 22.9 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(F)ccc4F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3986616 IC50 22.9 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1C1CCN(CCC(F)(F)F)CC1 CHEMBL3939825 IC50 22.9 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3cccc(-n4cccn4)c3)c2C2CC2)C1 CHEMBL3891211 IC50 23.0 nM
NC(=O)c1c(-c2ccccc2)c(C2CC2)n2c1CN(C(=O)NC1CCCCC1)CC2 CHEMBL3906975 IC50 23.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cccc(-c5ccncc5)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3896955 IC50 23.3 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccccc4)c(F)n3n2)c(-c2ccc(F)cc2)n1 CHEMBL3981818 IC50 23.3 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cscn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3975556 IC50 23.4 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(C#N)c(F)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3902451 IC50 23.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccncc4)cn3n2)c1N1CCN(CCC(F)(F)F)CC1 CHEMBL3965134 IC50 23.5 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cncc(-c5ccc(C#N)cc5)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3923163 IC50 23.9 nM
CC(C)(C)NC(=O)N1CCn2cc(-c3ccccc3)c(C(N)=O)c2C1 CHEMBL3939680 IC50 24.0 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc(OCC#N)cc3)c2C2CC2)C1 CHEMBL3945381 IC50 24.0 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc(C#N)cc3)c2C2CC2)C1 CHEMBL3941052 IC50 25.0 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3cccc(OC(F)(F)F)c3)c2C2CC2)C1 CHEMBL3952650 IC50 25.0 nM
NC(=O)c1c(-c2ccccc2)c(C2CC2)n2c1CN(C(=O)NCC1CCCCC1)CC2 CHEMBL3958013 IC50 25.0 nM
NC(=O)c1c(-c2ccccc2)c(Cl)n2c1CN(C(=O)NC1CCOCC1)CC2 CHEMBL3983847 IC50 25.0 nM
Cn1cc(-c2ccc3nc(NC(=O)C4CCC4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3939255 IC50 25.8 nM
c1ccc(-c2nc3ccc(N4CCC(N5CCCC5)CC4)nn3c2-c2ccncc2)cc1 CHEMBL4575936 IC50 26.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cncc(-c5ccccc5)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3963973 IC50 26.9 nM
Cn1cc(-c2ccnc3c2OCCNC3)c(-c2ccc(F)cc2)n1 CHEMBL2420703 IC50 27.0 nM
CN1CCC(F)(Cn2cnc(-c3ccc(F)cn3)c2-c2ccnc3[nH]ccc23)CC1 CHEMBL5303449 IC50 27.27 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(CCN5CCCC5)nc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3964687 IC50 27.8 nM
Cn1cc(-c2ccnc(C3COCCN3)c2)c(-c2ccc(F)cc2)n1 CHEMBL2420704 IC50 28.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(F)cc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3912546 IC50 28.1 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(OCC(F)(F)F)nc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3919122 IC50 28.1 nM
Cc1nocc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3895913 IC50 28.8 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(O)ncn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3941721 IC50 28.8 nM
Cc1nc(-c2ccccn2)sc1C(=O)Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3951534 IC50 28.8 nM
CC(C)(C)NC(=O)N1CCn2c(Cl)c(-c3cccc(OC(F)(F)F)c3)c(C(N)=O)c2C1 CHEMBL3919745 IC50 29.0 nM
Oc1ccc(CCn2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)cc1 CHEMBL5397065 IC50 30.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 31.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4csc(-c5ccncc5)n4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3966079 IC50 31.4 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(CCC(F)(F)F)CC1 CHEMBL3955665 IC50 31.6 nM
Nc1ncnc2c1c(COc1cccc(Cl)c1)nn2C1CCOCC1 CHEMBL2069623 IC50 32.0 nM
COc1ccc(-c2c(C(N)=O)c3n(c2C2CC2)CCN(C(=O)NC2CCOCC2)C3)cc1 CHEMBL3921431 IC50 32.0 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N)c4)cn3n2)c1N1CCN(CCC(F)(F)F)CC1 CHEMBL3909481 IC50 32.0 nM
O=C(Nc1nc2cc(Cl)c(F)cc2[nH]1)c1csc(NC(=O)c2ccccc2OC(F)(F)F)n1 CHEMBL3763630 IC50 32.6 nM
O=C(Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1)c1cccc(-c2cccnc2)c1 CHEMBL3895186 IC50 32.6 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc4ccccc4c3)c2C2CC2)C1 CHEMBL3911540 IC50 33.0 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc(OC(F)(F)F)cc3)c2C2CC2)C1 CHEMBL3971920 IC50 33.0 nM
O=C(Nc1nc2cc(Cl)c(F)cc2[nH]1)c1coc(NC(=O)c2ccccc2OC(F)(F)F)n1 CHEMBL5435232 IC50 33.0 nM
Cc1nc(-c2ccccc2)sc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3980426 IC50 34.1 nM
Cn1cc(-c2ccc3nc(NC(=O)C45CC6CC(C)(CC(C)(C6)C4)C5)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3893301 IC50 34.4 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cnccc4C(F)(F)F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3984487 IC50 34.8 nM
Cc1nc(-c2ccncc2)sc1C(=O)Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3936537 IC50 35.0 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(N5CCOCC5)c4)cn3n2)c1N1CCN(CCC(F)(F)F)CC1 CHEMBL3895315 IC50 35.0 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3cccc(C#N)c3)c2C2CC2)C1 CHEMBL3891697 IC50 36.0 nM
COCC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc(OC)cc3)c2C2CC2)C1 CHEMBL4108455 IC50 36.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cc4ccccc4s3)nc2c1F CHEMBL5413697 IC50 36.0 nM
CN1Cc2nccc(-c3cn(C)nc3-c3ccc(F)cc3)c2C1=O CHEMBL5303425 IC50 36.0 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3cccc(C(F)(F)F)c3)c2C2CC2)C1 CHEMBL3927852 IC50 38.0 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc(OCc4ccccc4)cc3)c2C2CC2)C1 CHEMBL3984983 IC50 38.0 nM
COc1ccncc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3962919 IC50 38.5 nM
Oc1ccc(-c2n[nH]c3ncc(-c4ccc(O)c(O)c4)cc23)cc1 CHEMBL4873449 IC50 38.9 nM
COc1ccc(-c2c(C(N)=O)c3n(c2C2CC2)CCN(C(=O)NC2(C4CC4)CC2)C3)cc1 CHEMBL4111894 IC50 40.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(OC(F)F)cc4F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3913183 IC50 40.9 nM
CC(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccccc3)c2C2CC2)C1 CHEMBL3940882 IC50 42.0 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc(OCc4ccc(F)cc4)cc3)c2C2CC2)C1 CHEMBL3897434 IC50 42.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccccn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3985580 IC50 42.0 nM
COc1ccc(-c2c(C(N)=O)c3n(c2C2CC2)CCN(C(=O)NC2CC2)C3)cc1 CHEMBL3967061 IC50 43.0 nM
CC1(C)CN(c2ccc3nc(-c4cc(F)cc(F)c4)c(-c4ccncc4)n3n2)CCN1 CHEMBL4528846 IC50 43.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccncn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3897438 IC50 43.4 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(F)c(C#N)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3938335 IC50 44.9 nM
CC(C)(C)CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccccc3)c2C2CC2)C1 CHEMBL4115354 IC50 45.0 nM
O=C(Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1)c1ccc(C(F)(F)F)nc1 CHEMBL3907683 IC50 45.2 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccccc3)c2C2CC2)C1 CHEMBL3950647 IC50 46.0 nM
O=C(Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1)c1cc(F)nc(F)c1 CHEMBL3924423 IC50 46.5 nM
Cn1cc(-c2ccc3nc(NC(=O)CC(F)(F)F)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3921458 IC50 47.3 nM
Cn1cc(-c2ccc3nc(Nc4ncccn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3894100 IC50 48.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ncccn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3937324 IC50 48.1 nM
CC(C)CNC(=O)N1CCn2c(c(C(N)=O)c(-c3ccccc3)c2C2CC2)C1 CHEMBL3928330 IC50 49.0 nM
OCC1CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4cccc(F)c4)c3n2)CC1 CHEMBL4209917 IC50 50.0 nM
Cn1cc(-c2ccc3nc(NC(=O)C4CC4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3981164 IC50 50.1 nM
CN1CCN(c2ccc(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cccc(F)c3)nc2)CC1 CHEMBL4211222 IC50 54.0 nM
Cc1c(-c2ccccc2)c(C(N)=O)c2n1CCN(C(=O)NC(C)(C)C)C2 CHEMBL3910910 IC50 55.0 nM
COc1ccc(-c2ccc(-c3c(C(N)=O)c4n(c3C)CCN(C(=O)NC(C)(C)C)C4)cc2)cc1 CHEMBL3969798 IC50 56.0 nM
Cc1nc2ccc(N3CCNCC3)nn2c1-c1ccncc1 CHEMBL5279523 IC50 57.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3ccc4ccccc4c3)nc2c1F CHEMBL5424568 IC50 58.0 nM
COc1ncccc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3889710 IC50 60.2 nM
COc1ccc(-c2c(C(N)=O)c3n(c2C2CC2)CCN(C(=O)NC(C)(C)C)C3)cc1 CHEMBL3924940 IC50 61.0 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc(OCC4CC4)cc3)c2C2CC2)C1 CHEMBL4106631 IC50 62.0 nM
O=C1NC(NC23CC4(F)CC(F)(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5422486 IC50 62.0 nM
Cc1nocc1C(=O)Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3919335 IC50 63.5 nM
CCc1ccc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)nc1 CHEMBL3983364 IC50 64.0 nM
Cc1nnc(-c2ccc(-c3c(C(N)=O)c4n(c3C3CC3)CCN(C(=O)NC(C)(C)C)C4)cc2)o1 CHEMBL3976083 IC50 65.0 nM
CNCc1cc(-c2cn(C)nc2-c2ccc(F)cc2)ccn1 CHEMBL2420702 IC50 67.2 nM
c1ccc(-c2nc3ccc(N4CC5CC4CN5)nn3c2-c2ccncc2)cc1 CHEMBL4573899 IC50 70.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ncc(-c5ccccn5)s4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3893155 IC50 71.5 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cnccn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3937466 IC50 72.6 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 73.0 nM
COc1ccc(/C=C/C(=O)Nc2cc(-c3[nH]c(SC)nc3-c3ccc(F)cc3)ccn2)c(OC)c1 CHEMBL569114 IC50 73.0 nM
O=C(Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1)c1csc(-c2ccncc2)n1 CHEMBL3976870 IC50 74.9 nM
COc1cc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)nc(OC)n1 CHEMBL3913000 IC50 75.7 nM
CN(C)Cc1ccccc1C(=O)Nc1cn2nc(-c3cn(C)nc3-c3ccc(F)cc3)ccc2n1 CHEMBL3969521 IC50 76.9 nM
Fc1cccc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)c1F CHEMBL4203375 IC50 80.0 nM
Cn1cc(-c2ccnc(CO)c2)c(-c2ccc(F)cc2)n1 CHEMBL2420701 IC50 81.6 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc(C(F)(F)F)cc3)c2C2CC2)C1 CHEMBL3905300 IC50 84.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4CCc3ccoc3)nc2c1F CHEMBL5419193 IC50 88.0 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc(F)cc3)c2C2CC2)C1 CHEMBL3915940 IC50 91.0 nM
CC1(C)Cn2nc(-c3ccc(F)cn3)c(-c3ccnc4[nH]ncc34)c2CO1 CHEMBL5095777 IC50 93.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL607707 Kd 97.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(C(C)(C)C)ncn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3936977 IC50 98.3 nM
CCCNc1ccc2ncc(-c3ccc4[nH]ncc4c3)n2n1 CHEMBL5178368 IC50 99.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccnc(C(C)(C)C)c4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3923511 IC50 99.9 nM
C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL10 Kd 100.0 nM
CCN1/C(=C\C(C)=O)Sc2ccc(OC)cc21 CHEMBL1349996 Kd 100.0 nM
Cc1nc2c(cnn2-c2csc(C(=O)NC3COC3)c2)cc1Nc1c(F)cccc1Cl CHEMBL4845770 IC50 100.0 nM
CS(=O)(=O)c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL280317 Kd 100.0 nM
Fc1ccc(CCn2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)cc1 CHEMBL5435094 IC50 100.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccncc4)c(Br)n3n2)c(-c2ccc(F)cc2)n1 CHEMBL3958331 IC50 102.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4csc(-c5ccccc5)n4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3891165 IC50 104.1 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3ccsc3)nc2c1F CHEMBL4206247 IC50 105.0 nM
Clc1cc2nc(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cccnc3)[nH]c2cc1Cl CHEMBL4218827 IC50 105.0 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 110.0 nM
[2H]C([2H])([2H])C1(C([2H])([2H])[2H])Cn2nc(-c3ccc(F)cn3)c(-c3ccnc4[nH]ncc34)c2CO1 CHEMBL5081774 IC50 110.0 nM
COc1ccc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)cc1 CHEMBL5428835 IC50 110.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4CCc3ccsc3)nc2c1F CHEMBL5414012 IC50 110.0 nM
Cn1cc(-c2ccc3nc(NC(=O)Nc4ccccc4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3977152 IC50 114.0 nM
Fc1cccc(-n2cnc3c(NCc4nc5ccccc5s4)nc(N4CCOCC4)nc32)c1 CHEMBL4211301 IC50 115.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4nccs4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3921992 IC50 115.5 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 Kd 120.0 nM
NC(=O)c1c(-c2cccc(OC(F)(F)F)c2)c(Cl)n2c1CN(C(=O)NC1CCOCC1)CC2 CHEMBL3898543 IC50 122.0 nM
Cn1nc(-c2ccc(F)cc2)c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)c1N1CCN(CCS(C)(=O)=O)CC1 CHEMBL3970214 IC50 124.0 nM
CN1CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4ccsc4)c3n2)CC1 CHEMBL4203268 IC50 125.0 nM
OCCn1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncc2)n1 CHEMBL525191 Kd 130.0 nM
OCCn1cc(-c2ccc3c(c2)CCC3=NO)c(-c2ccncc2)n1 CHEMBL2139930 Kd 130.0 nM
CN1CCC(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)CC1 CHEMBL3914705 IC50 134.9 nM
Cc1ccccc1-n1cnc2c(NCc3nc4c(F)c(F)ccc4[nH]3)nc(N3CCOCC3)nc21 CHEMBL4217142 IC50 135.0 nM
Cc1c(NC(=O)c2ccccc2)nc2ccc(-c3cn(C)nc3-c3ccc(F)cc3)nn12 CHEMBL3901909 IC50 137.0 nM
Fc1cc(F)cc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)c1 CHEMBL4207079 IC50 145.0 nM
Cn1cc(-n2cnc3c(NCc4nc5cc(Cl)c(Cl)cc5[nH]4)nc(N4CCOC[C@@H]4CO)nc32)cn1 CHEMBL4849960 IC50 145.0 nM
Fc1cccc(-n2cnc3c(NCc4nc5ccccc5o4)nc(N4CCOCC4)nc32)c1 CHEMBL4215691 IC50 150.0 nM
CCCCOc1ccc(-c2c(C(N)=O)c3n(c2C2CC2)CCN(C(=O)NC(C)(C)C)C3)cc1 CHEMBL3919726 IC50 152.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccccc4)c(Cl)n3n2)c(-c2ccc(F)cc2)n1 CHEMBL3949680 IC50 153.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cccc(C(F)(F)F)n4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3928838 IC50 157.5 nM
Cc1nc2cc(-c3nn(C(C)C)c4ncnc(N)c34)ccc2o1 CHEMBL3991933 Kd apparent 158.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 159.0 nM
CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 CHEMBL14762 Kd 160.0 nM
COc1cccc(C(=O)Nc2nc3cc4c(cc3[nH]2)OC(F)(F)O4)c1 CHEMBL3337846 IC50 160.0 nM
CN(C)c1nccn2c(-c3ccnc(N)n3)c(-c3ccc(F)cc3)nc12 CHEMBL4870529 IC50 160.0 nM
Oc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL278041 Kd 170.0 nM
Nc1nc(NCc2nc3c(F)c(F)ccc3[nH]2)c2ncn(-c3cccc(F)c3)c2n1 CHEMBL4211791 IC50 170.0 nM
O=C(Nc1cn2nc(-c3cn(C4CC4)nc3-c3ccc(F)cc3)ccc2n1)C1CC1 CHEMBL3987095 IC50 170.2 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3ccccc3C(F)(F)F)nc2c1F CHEMBL4206998 IC50 175.0 nM
CSc1nccc(-c2c(-c3ccc(F)cc3)nc3c(N)nccn23)n1 CHEMBL4877608 IC50 180.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cccc4ccccc34)nc2c1F CHEMBL5398768 IC50 180.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cc4ccccc4cn3)nc2c1F CHEMBL5409996 IC50 180.0 nM
O=C(Nc1nc2cc3c(cc2[nH]1)OC(F)(F)O3)c1csc(NC(=O)c2ccccc2OC(F)(F)F)n1 CHEMBL3337845 IC50 190.0 nM
O=C(Nc1nc2ccc(C(F)(F)F)cc2[nH]1)c1csc(NC(=O)c2ccccc2OC(F)(F)F)n1 CHEMBL3337854 IC50 199.0 nM
Nc1nccc(-c2c(-c3ccc(F)cc3)nc3c(N)nccn23)n1 CHEMBL4853288 IC50 200.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4CCc3cccc(Cl)c3)nc2c1F CHEMBL5415170 IC50 200.0 nM
Nc1ncc(-c2cc([N+](=O)[O-])ccc2F)cc1-c1ccc2c(c1)CCNC2=O CHEMBL4874241 % inhibition 201.0 nM
Fc1cccc(-n2cnc3c(NCc4ncc[nH]4)nc(N4CCOCC4)nc32)c1 CHEMBL4215749 IC50 205.0 nM
OCCNc1nc(NCc2nc3c(F)c(F)ccc3[nH]2)c2ncn(-c3cccc(F)c3)c2n1 CHEMBL4215056 IC50 205.0 nM
COC1CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4cccc(F)c4)c3n2)CC1 CHEMBL4204292 IC50 205.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cnc4ccccc4c3)nc2c1F CHEMBL5434512 IC50 220.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4CCc3cccc(Br)c3)nc2c1F CHEMBL5440959 IC50 220.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 230.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3ccc4ncsc4c3)nc2c1F CHEMBL5413238 IC50 230.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccc(C(F)(F)F)cn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3910210 IC50 232.3 nM
CSc1ccc(CCn2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)cc1 CHEMBL5438046 IC50 240.0 nM
Fc1cc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)ccn1 CHEMBL4218717 IC50 245.0 nM
Cc1cc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)ccn1 CHEMBL4210537 IC50 245.0 nM
COc1ccc(-c2c(C(N)=O)c3n(c2C2CC2)CCN(C(=O)NC(C)C)C3)cc1 CHEMBL3955946 IC50 247.0 nM
Fc1ccc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)c(F)c1 CHEMBL4208642 IC50 250.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3ccc4c(c3)OCCO4)nc2c1F CHEMBL5431532 IC50 250.0 nM
Clc1cc2nc(CNc3nc(N4CCNCC4)nc4c3ncn4-c3cccnc3)[nH]c2cc1Cl CHEMBL4209206 IC50 255.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccccc4)c(Br)n3n2)c(-c2ccc(F)cc2)n1 CHEMBL3944359 IC50 257.0 nM
NC(=O)c1ccc(-c2nc(-c3ccccn3)c(-c3ccc4c(c3)OCO4)[nH]2)cc1 CHEMBL440084 Kd 260.0 nM
Cn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC(CCO)CCO)nc21 CHEMBL1090089 Kd 260.0 nM
Fc1cccc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)c1 CHEMBL4211454 IC50 260.0 nM
O=C1CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4cccc(F)c4)c3n2)CC1 CHEMBL4217426 IC50 265.0 nM
Fc1cccc(-n2cnc3c(NCc4nc(-c5ccccc5)c[nH]4)nc(N4CCOCC4)nc32)c1 CHEMBL4210412 IC50 280.0 nM
c1cc(OCCN2CCCCC2)cc(-c2n[nH]c3ccc(-c4nnc[nH]4)cc23)c1 CHEMBL1614713 Kd apparent 285.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL180022 Kd 290.0 nM
CCN1/C(=C/C(C)=O)Sc2ccc(OC)cc21 CHEMBL408982 Kd 300.0 nM
Cn1cc(-c2ccncc2)c(-c2ccc(F)cc2)n1 CHEMBL2420700 IC50 305.0 nM
CN1CCC(Nc2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4cccc(F)c4)c3n2)CC1 CHEMBL4205719 IC50 305.0 nM
Fc1cccc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCSCC4)nc32)c1 CHEMBL4203904 IC50 310.0 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3cccc(Oc4ccccc4)c3)c2C2CC2)C1 CHEMBL3959073 IC50 315.0 nM
CN1CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4ccncc4)c3n2)CC1 CHEMBL4218574 IC50 315.0 nM
O=C(Nc1nc2cc3c(cc2[nH]1)OC(F)(F)O3)c1cccc(OC(F)F)c1 CHEMBL3337851 IC50 320.0 nM
CN1CCN(c2nc(NCc3nc4cc(Cl)c(Cl)cc4[nH]3)c3ncn(-c4cccnc4)c3n2)CC1 CHEMBL4211678 IC50 320.0 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc(N4CCOCC4)cc3)c2C2CC2)C1 CHEMBL3959552 IC50 331.0 nM
COc1ccc2nc(CNc3nc(N4CCN(C)CC4)nc4c3ncn4-c3cccnc3)[nH]c2c1 CHEMBL4216393 IC50 335.0 nM
NC(=O)c1ccc(-c2nc(-c3ccc4c(c3)OCCO4)c(-c3ccccn3)[nH]2)cc1 CHEMBL410456 IC50 338.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 340.0 nM
Fc1cc2nc(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cccnc3)[nH]c2cc1F CHEMBL4205151 IC50 340.0 nM
Fc1cccc(CCn2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)c1 CHEMBL5407178 IC50 340.0 nM
COc1ccc(C(=O)Nc2cn3nc(-c4cn(C)nc4-c4ccc(F)cc4)ccc3n2)c(OC)n1 CHEMBL3913546 IC50 363.0 nM
O=C(O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1 CHEMBL297453 IC50 365.0 nM
CNC(=O)c1nn(C)c2c1C(C)(C)Cc1cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc1-2 CHEMBL564829 Kd apparent 366.0 nM
O=S1(=O)CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4cccc(F)c4)c3n2)CC1 CHEMBL4212734 IC50 370.0 nM
Fc1cccc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(NCC4CCOCC4)nc32)c1 CHEMBL4213205 IC50 375.0 nM
CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1 CHEMBL513909 Kd 380.0 nM
CN1CCN(c2ccc(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cccc(F)c3)cc2)CC1 CHEMBL4203539 IC50 380.0 nM
Nc1nc2ccc(Br)cc2c2nc(-c3ccco3)nn12 CHEMBL5186013 IC50 380.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3ccncc3)nc2c1F CHEMBL4206835 IC50 385.0 nM
Cc1cc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCN(C)CC4)nc32)ccn1 CHEMBL4211128 IC50 385.0 nM
CCOc1ccc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)cc1 CHEMBL5434162 IC50 390.0 nM
Fc1ccc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)cc1 CHEMBL4213060 IC50 395.0 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnc2ccc(Br)cn12 CHEMBL393525 IC50 405.0 nM
C=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1 CHEMBL31965 Kd 420.0 nM
CN(C)c1cc(C(=O)Nc2nc3cc4c(cc3[nH]2)OC(F)(F)O4)ccn1 CHEMBL3337850 IC50 420.0 nM
O=C1NC(NC2CCCCC(F)(F)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5396550 IC50 420.0 nM
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 CHEMBL939 Kd 430.0 nM
COc1ccc(/C=C/C(=O)Nc2cc(-c3[nH]c([S+](C)[O-])nc3-c3ccc(F)cc3)ccn2)c(OC)c1 CHEMBL572006 IC50 447.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4cc(-c5ccc(F)cc5)ncn4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3899986 IC50 454.1 nM
CN(C)c1cccc(C(=O)Nc2nc3cc4c(cc3[nH]2)OC(F)(F)O4)c1 CHEMBL3337849 IC50 460.0 nM
N#Cc1ccc(CCn2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)cc1 CHEMBL5402454 IC50 460.0 nM
Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12 CHEMBL16687 IC50 490.0 nM
C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 CHEMBL553 Kd 500.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cccnc3)nc2c1F CHEMBL4209644 IC50 500.0 nM
COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 CHEMBL1908396 Kd 520.0 nM
CN(C)S(=O)(=O)Nc1cccc(-c2c(C(N)=O)c3n(c2C2CC2)CCN(C(=O)NC(C)(C)C)C3)c1 CHEMBL3905405 IC50 521.0 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc(NS(C)(=O)=O)cc3)c2C2CC2)C1 CHEMBL3971233 IC50 532.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4ccncc4)c(-c4ccncc4)n3n2)c(-c2ccc(F)cc2)n1 CHEMBL3987018 IC50 554.0 nM
COc1ccc(Cn2c(SCC(=O)Nc3nc4ccc(C(F)(F)F)cc4s3)nc3c(c2=O)SCC3)cc1 CHEMBL4204681 IC50 560.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4CCc3cccc(C(F)(F)F)c3)nc2c1F CHEMBL5395469 IC50 570.0 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc(C(=O)N4CCCC4)cc3)c2C2CC2)C1 CHEMBL3891032 IC50 587.0 nM
COc1cc(OC)c(/C=C2\C(=O)Nc3ccccc32)c(OC)c1 CHEMBL404941 IC50 600.0 nM
COC(=O)c1cccc(C(=O)Nc2nc3cc4c(cc3[nH]2)OC(F)(F)O4)c1 CHEMBL3337852 IC50 600.0 nM
O=C1NC(NC23CC4CC(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5438158 IC50 612.0 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc(C4CCCCC4)cc3)c2C2CC2)C1 CHEMBL3929387 IC50 613.0 nM
O=C(Nc1nc2cc3c(cc2[nH]1)OC(F)(F)O3)c1cccc(-c2nnn[nH]2)c1 CHEMBL3337853 IC50 620.0 nM
COCNC(=O)c1ccc(-c2c(C(N)=O)c3n(c2C2CC2)CCN(C(=O)NC(C)(C)C)C3)cc1 CHEMBL3919092 IC50 620.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 630.0 nM
CN1CCN(c2nc(NCc3nc4cc(Cl)ccc4[nH]3)c3ncn(-c4cccnc4)c3n2)CC1 CHEMBL4203354 IC50 630.0 nM
CC(C)Oc1ccc(F)c(-c2cnc(N)c(C(=O)Nc3cnccc3N3CCC[C@@H](C(=O)O)C3)n2)c1 CHEMBL4647659 IC50 630.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cncs3)nc2c1F CHEMBL4849684 IC50 632.0 nM
CNC1CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4cccc(F)c4)c3n2)CC1 CHEMBL4210085 IC50 655.0 nM
CN1CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4ccnc(F)c4)c3n2)CC1 CHEMBL4215429 IC50 660.0 nM
CN1CCN(c2nc(NCc3nc4cc(F)c(F)cc4[nH]3)c3ncn(-c4cccnc4)c3n2)CC1 CHEMBL4216088 IC50 660.0 nM
Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4Cc3cccc4ccccc34)nc2c1F CHEMBL5426950 IC50 690.0 nM
FC(F)n1cc(-n2cnc3c(NCc4nc5cc(Cl)c(Cl)cc5[nH]4)nc(N4CCOCC4)nc32)cn1 CHEMBL4867928 IC50 709.0 nM
Clc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cccnc3)nc2c1 CHEMBL4205223 IC50 715.0 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc(C4CC4)cc3)c2C2CC2)C1 CHEMBL3913940 IC50 725.0 nM
Fc1cc(F)cc(CCn2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)c1 CHEMBL5406394 IC50 740.0 nM
O=C(NCCCN1CCOC1=O)c1cnc(NCc2cc(Cl)ccc2Cl)nc1NC1CCCC1 CHEMBL2312304 Kd 770.0 nM
CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3c(cc2OC)CCN3C(=O)CN(C)C)nc2[nH]ccc12 CHEMBL464552 Kd 780.0 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 Kd apparent 841.0 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3cccc(OC4CC4)c3)c2C2CC2)C1 CHEMBL3984305 IC50 847.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 CHEMBL450786 Kd 860.0 nM
CN1CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4ccccn4)c3n2)CC1 CHEMBL4214158 IC50 860.0 nM
CN1CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)c3ncn(-c4ccc(Cl)nc4)c3n2)CC1 CHEMBL4202462 IC50 860.0 nM
CN(C)C(=O)c1ccc(N2CCCN(c3ccnc4sc(C(N)=O)c(N)c34)CC2)cc1 CHEMBL2348350 Kd 860.0 nM
Cn1cc(-c2ccc3nc(NC(=O)c4csc(-c5ccc(Cl)cc5)n4)cn3n2)c(-c2ccc(F)cc2)n1 CHEMBL3967195 IC50 898.6 nM
CC(C)Oc1ccc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)cc1 CHEMBL5438462 IC50 910.0 nM
Clc1ccc2[nH]c(CNc3nc(N4CCNCC4)nc4c3ncn4-c3cccnc3)nc2c1 CHEMBL4205502 IC50 915.0 nM
CN(C)c1nccn2c(-c3ccncc3)c(-c3ccc(F)cc3)nc12 CHEMBL3634367 IC50 920.0 nM
CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 CHEMBL296468 Kd 950.0 nM
CN(C)C(=O)c1cccc(-c2c(C(N)=O)c3n(c2C2CC2)CCN(C(=O)NC(C)(C)C)C3)c1 CHEMBL3896502 IC50 958.0 nM
CC(C)(C)NC(=O)N1CCn2c(c(C(N)=O)c(-c3ccc(C(=O)NC4CC4)cc3)c2C2CC2)C1 CHEMBL3899871 IC50 963.0 nM
COc1ccc2nc(CNc3nc(N4CCOCC4)nc4c3ncn4-c3cccnc3)[nH]c2c1 CHEMBL4213254 IC50 975.0 nM
COc1cncc(C(=O)Nc2nc3cc4c(cc3[nH]2)OC(F)(F)O4)c1 CHEMBL3337847 IC50 990.0 nM
Fc1ccc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)cc1F CHEMBL4216824 IC50 990.0 nM
COc1cc(OC)c(/C=C2/C(=O)Nc3ccccc32)c(OC)c1 CHEMBL489156 IC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM