Cc1cc(C)cc(NC(=O)Nc2ccc(-c3c(C)sc4ncnc(N)c34)cc2)c1 CHEMBL371206 pKi 3.981 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 CHEMBL2003638 pKi 12.59 nM
Clc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 CHEMBL1969588 pKi 15.85 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 15.85 nM
O=C(c1cc(-c2ccc3[nH]ncc3c2)on1)N1CCCC(O)C1 CHEMBL1997340 pKi 19.95 nM
NC(=O)c1sc2ccc(Cl)c(Cl)c2c1NC(=O)c1ccc(Cl)cc1 CHEMBL2003271 pKi 19.95 nM
Clc1csc2ncnc(Nc3ccccc3)c12 CHEMBL1986139 pKi 19.95 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1967531 pKi 19.95 nM
CCCS(=O)(=O)Nc1ccc(-c2ccc3[nH]nc(NC(C)=O)c3c2)cc1 CHEMBL1973893 pKi 19.95 nM
Cc1ccccc1NC(=O)Nc1ccc(-c2coc3ncnc(N)c23)cc1 CHEMBL1984586 pKi 19.95 nM
Cc1ccc(C(=O)Nc2c(C#N)sc3ccc(Cl)c(Cl)c23)cc1 CHEMBL2006785 pKi 19.95 nM
Cc1ccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)cc1 CHEMBL2005828 pKi 19.95 nM
COc1cc(C=C2SC(=S)NC2=O)ccc1O CHEMBL1973098 pKi 19.95 nM
COc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1OC CHEMBL1991078 pKi 25.12 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 25.12 nM
N#Cc1ccc2nc(N)n(-c3nc(-c4ccccc4)cs3)c2c1 CHEMBL1996066 pKi 31.62 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 39.81 nM
COc1cccc(C=C2SC(=Nc3ccccc3)NC2=O)c1 CHEMBL1972937 pKi 39.81 nM
Cc1ccc2c(c1)NC(=O)c1ccccc1N2 CHEMBL1999714 pKi 39.81 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1F CHEMBL1981079 pKi 50.12 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 Kd apparent 53.0 nM
CC(=O)c1c(-c2ccncc2)[nH]c(-c2ccncc2)c1C CHEMBL526901 Kd 59.0 nM
Nc1nnc(-c2cc3c(Oc4ccc(Cl)cc4)cncc3s2)o1 CHEMBL1994830 pKi 63.1 nM
Cc1n[nH]c2cnc(-c3cncc(OCC(N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL1998159 pKi 63.1 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 79.43 nM
Cc1cccc(-c2[nH]c(-c3ccnc(N)n3)cc2C(N)=O)c1C CHEMBL1964290 pKi 79.43 nM
Cc1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 CHEMBL1989646 pKi 79.43 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 100.0 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 100.0 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCCCC2)n1 CHEMBL2006439 pKi 125.89 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 125.89 nM
Cc1ccc(CNc2c(Nc3ccncc3)c(=O)c2=O)cc1 CHEMBL1994864 pKi 158.49 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 158.49 nM
Cc1ccc(Nc2nc3ccc([N+](=O)[O-])cc3[nH]2)nc1 CHEMBL1992937 pKi 158.49 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 158.49 nM
O=c1c(NCc2ccc(Cl)c(Cl)c2)c(Nc2ccncc2)c1=O CHEMBL1975900 pKi 158.49 nM
NC(=O)C(Nc1c(Nc2ccncc2)c(=O)c1=O)c1cccc(O)c1 CHEMBL511410 IC50 160.0 nM
C[C@@H](Nc1c(Nc2ccncc2)c(=O)c1=O)c1ccccc1 CHEMBL466496 IC50 250.0 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)cncc21 CHEMBL1964692 pKi 251.19 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 251.19 nM
Cc1nnc(-c2cc3c(Oc4ccc(C(F)(F)F)cc4)cncc3s2)o1 CHEMBL1988153 pKi 251.19 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4cnc5ccccc5c4)c3)cc21 CHEMBL226403 pKi 251.19 nM
CC(=O)NC1CCN(c2nc3[nH]cc(C(=O)O)c(=O)c3c(C)c2F)C1 CHEMBL1975208 pKi 251.19 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL225519 pKi 251.19 nM
c1cc(OCCN2CCCCC2)cc(-c2n[nH]c3ccc(-c4nnc[nH]4)cc23)c1 CHEMBL1614713 Kd apparent 282.0 nM
CN1CCC(C(=O)n2nc(N)c3cc(-c4cn(Cc5ccccc5)nn4)ccc32)CC1 CHEMBL1978014 pKi 316.23 nM
c1cc2[nH]ncc2cc1-c1cn(CC2CCOCC2)nn1 CHEMBL1969843 pKi 316.23 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 316.23 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 316.23 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 316.23 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 316.23 nM
O=c1c(NCc2ccc(Cl)cc2)c(Nc2ccncc2)c1=O CHEMBL1980489 pKi 316.23 nM
CC(Nc1c(Nc2ccncc2)c(=O)c1=O)C(C)(C)C CHEMBL1986186 pKi 398.11 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccccc4)c3)cc12 CHEMBL2002726 pKi 398.11 nM
CCc1nc(-c2cccc(C)c2)c(-c2ccnc(NC(=O)c3ccccc3)c2)s1 CHEMBL363648 pKi 398.11 nM
NC(=O)c1cc2c(Oc3ccc(Br)cc3)cncc2s1 CHEMBL116070 pKi 398.11 nM
CC1CSc2c(C(=O)O)c(=O)c3cc(F)c(N4CCC(N)C4)c(F)c3n21 CHEMBL1977604 pKi 501.19 nM
O=c1c(NCc2cccc(C(F)(F)F)c2)c(Nc2ccncc2)c1=O CHEMBL1979252 pKi 501.19 nM
O=C(NCc1ccc(Cl)c(Cl)c1)Nc1ccc2[nH]ncc2c1 CHEMBL1981782 pKi 501.19 nM
NCCCOc1cc2c(c(-c3ccc(Nc4nc5ccc(Cl)cc5o4)cc3)c1)CNC2=O CHEMBL2002479 pKi 501.19 nM
NC(=O)C(Nc1c(Nc2ccncc2)c(=O)c1=O)c1ccccc1 CHEMBL467079 IC50 520.0 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 Kd 530.0 nM
O=C(NC(CO)Cc1ccc(Cl)cc1)c1ccc(-c2ccncc2)cc1 CHEMBL1996931 pKi 630.96 nM
COc1ccc(C(=O)Nc2cnc3[nH]cc(-c4ccccc4)c3c2)cc1 CHEMBL1997764 pKi 630.96 nM
NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(-c3ccncc3)ccc2c1=O CHEMBL340384 pKi 630.96 nM
CS(=O)(=O)N(Cc1ccc2[nH]c(=O)c3cccn3c2c1)C1CC1 CHEMBL1978448 pKi 630.96 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4ccccc4F)c3)cc21 CHEMBL226471 pKi 630.96 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)csc12 CHEMBL2005631 pKi 630.96 nM
CC(C)(C(N)=O)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1967720 pKi 630.96 nM
CSc1ccccc1CNc1ncc([N+](=O)[O-])c(NCC2CCC(CN)CC2)n1 CHEMBL392642 pKi 630.96 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 630.96 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 665.0 nM
O=C(Nc1nc2ccccc2n1CCCO)c1cccc([N+](=O)[O-])c1 CHEMBL210887 pKi 794.33 nM
NC(=O)c1cc2c(-c3ccc(F)cc3)cncc2s1 CHEMBL1974310 pKi 794.33 nM
Cc1cccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)c1 CHEMBL1983963 pKi 794.33 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cncc4c3c(N)nn4C)cc2)c1 CHEMBL404367 pKi 794.33 nM
CC(=O)N(c1ccncc1)c1c(NC(C)C(C)(C)C)c(=O)c1=O CHEMBL2005899 pKi 794.33 nM
CC(Nc1nccc(-c2c(-c3ccc(F)cc3)nc3occn23)n1)c1ccccc1 CHEMBL1990288 pKi 794.33 nM
NCCC(C(=O)Nc1ccc2[nH]ncc2c1)c1ccc(Cl)c(Cl)c1 CHEMBL1998121 pKi 794.33 nM
CC(C)(CO)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3c(CCN)nccn23)n1 CHEMBL1982383 pKi 794.33 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2C CHEMBL519697 pKi 794.33 nM
Fc1ccc(-c2nc3occn3c2-c2ccnc(NC3CCNCC3)n2)cc1 CHEMBL1971186 pKi 794.33 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1789941 Kd apparent 851.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 930.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 1000.0 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 1000.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)c1 CHEMBL196363 pKi 1000.0 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 1000.0 nM
O=c1nc(-c2cc3c(Oc4ccc(I)cc4)cncc3s2)[nH]o1 CHEMBL497151 pKi 1000.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cncc4c3c(N)nn4C)cc2)c1 CHEMBL402846 pKi 1000.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 1000.0 nM
OCCC(Nc1nc2ccc(-c3ccncc3)cc2s1)c1ccccc1 CHEMBL1982122 pKi 1000.0 nM
COc1cccc(C(=O)Nc2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982924 pKi 1000.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCCC5)cnc(N)c34)cc2)c1 CHEMBL1973211 pKi 1000.0 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL1972158 pKi 1000.0 nM
NC(=O)c1cc2c(Oc3cccc(F)c3)cncc2s1 CHEMBL1964777 pKi 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM