[C-]#[N+]c1cnc2c(Nc3nc(C)n(C)n3)nc(Nc3ccc4c(c3)c(C#N)nn4C)nn12 CHEMBL3699289 IC50 0.03 nM
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(N2CCC(O)C2)c1 CHEMBL3699235 IC50 0.07 nM
COC(=O)N[C@@H]1CCN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)C[C@H]1OP(=O)(O)O CHEMBL3699276 IC50 0.09 nM
Cn1nc(C#N)c2cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)ccc21 CHEMBL3699234 IC50 0.09 nM
N#Cc1cc(CO)c(Cl)c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1 CHEMBL3699295 IC50 0.11 nM
CS(=O)(=O)C1CCN(C2CN(c3cc(C#N)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)C2)C1 CHEMBL3699252 IC50 0.11 nM
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(NN2CCOCC2)c1 CHEMBL3699237 IC50 0.11 nM
[C-]#[N+]c1cnc2c(NCC)nc(Nc3cc(C#N)cc(N4CC[C@H](NC(=O)OC)[C@@H](O)C4)c3Cl)nn12 CHEMBL3699282 IC50 0.13 nM
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(N2CCC(NC3CCS(=O)(=O)C3)CC2)c1 CHEMBL3699244 IC50 0.15 nM
C=Cc1cc(C#N)cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl CHEMBL3699294 IC50 0.16 nM
CC(=O)N1CCC(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)CC1 CHEMBL3699266 IC50 0.16 nM
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(N2CCN(C3CCOC3)CC2)c1 CHEMBL3699238 IC50 0.2 nM
[C-]#[N+]c1cnc2c(NC3CC3)nc(Nc3cc(C#N)cc(N4CCN(C5COC5)CC(F)C4)c3Cl)nn12 CHEMBL3699278 IC50 0.21 nM
CCNc1nc(Nc2ccc3c(c2)c(C#N)nn3C2CCN(C[C@@H](C)O)CC2)nn2c(C#N)cnc12 CHEMBL3699292 IC50 0.21 nM
CCNc1nc(Nc2cc(C#N)cc(N3CCN(C4COC4)CC3)c2Cl)nn2c(C#N)cnc12 CHEMBL3699296 IC50 0.23 nM
CN1CC=C(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)CC1 CHEMBL3699262 IC50 0.23 nM
CC(=O)N1CC(N2CCC(c3cc(C#N)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)CC2)C1 CHEMBL3699280 IC50 0.25 nM
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(N2CC[C@@H](NC(=O)OC3COC3)[C@H](O)C2)c1 CHEMBL3699259 IC50 0.26 nM
CCNc1nc(Nc2ccc3c(c2)c(C#N)nn3C2CCN(C[C@H](C)O)CC2)nn2c(C#N)cnc12 CHEMBL3699291 IC50 0.27 nM
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(N2CC(N3CC(O)C3)C2)c1 CHEMBL3699255 IC50 0.27 nM
COC(=O)N[C@@H]1CCN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)C[C@H]1O CHEMBL3699256 IC50 0.27 nM
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(C2CCN(C(=O)OC3COC3)CC2)c1 CHEMBL3699267 IC50 0.27 nM
C[C@@H](O)CN1CCN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)CC1 CHEMBL3699239 IC50 0.28 nM
COC1CCN(C2CN(c3cc(C#N)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)C2)C1 CHEMBL3699253 IC50 0.31 nM
COC(=O)N[C@H]1CCN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)C[C@@H]1O CHEMBL3699257 IC50 0.35 nM
COC(=O)N[C@@H]1CCN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)C[C@@H]1F CHEMBL3699277 IC50 0.45 nM
CN1CC(N2CCN(c3cc(C(F)F)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)CC2)C1 CHEMBL3699269 IC50 0.47 nM
COC(=O)N[C@@H]1CN(C2CN(c3cc(C#N)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)C2)C[C@H]1C CHEMBL3699254 IC50 0.49 nM
COCCOC(=O)N[C@@H]1CCN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)C[C@H]1O CHEMBL3699258 IC50 0.49 nM
CCNc1nc(Nc2cc(C#N)cc(N3CC[C@@H]4[C@@H](C3)OCCN4C3COC3)c2Cl)nn2c(C#N)cnc12 CHEMBL3699286 IC50 0.52 nM
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(N2CCC(N[C@H]3C[C@@H](O)C3)CC2)c1 CHEMBL3699250 IC50 0.54 nM
[C-]#[N+]c1cnc2c(NCC)nc(Nc3cc(C#N)cc(N4CCC(NC[C@@H](C)O)CC4)c3Cl)nn12 CHEMBL3699285 IC50 0.61 nM
[C-]#[N+]c1cnc2c(NC3CC3)nc(Nc3cc(C#N)cc(N4CC(N5CCN(C)CC5)C4)c3F)nn12 CHEMBL3699287 IC50 0.61 nM
CN1CCN(CC(=O)N[C@@H]2CCN(c3cc(C#N)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)C[C@H]2O)CC1 CHEMBL3699260 IC50 0.64 nM
[C-]#[N+]c1cnc2c(NC3CC3)nc(Nc3cc(C#N)cc(N4CCC(NC5CC(F)(F)C5)CC4)c3Cl)nn12 CHEMBL3699242 IC50 0.7 nM
CCNc1nc(Nc2cc(C#N)cc(N3CCN(CC(F)F)CC3)c2Cl)nn2c(C#N)cnc12 CHEMBL3699303 IC50 0.74 nM
CC1(N2CCN(c3cc(C(F)F)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)CC2)COC1 CHEMBL3699274 IC50 0.75 nM
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(C2CCN(C3CC(CO)(CO)C3)CC2)c1 CHEMBL3699264 IC50 0.76 nM
[C-]#[N+]c1cnc2c(NCC)nc(Nc3cc(C#N)cc(C4CCNCC4)c3Cl)nn12 CHEMBL3699284 IC50 0.76 nM
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(NC2CCN(C3COC3)CC2)c1 CHEMBL3699297 IC50 0.82 nM
CN1CC2(C1)CN(c1cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c1Cl)C2 CHEMBL3699236 IC50 0.87 nM
COC(=O)N1CCC(N2CCN(c3cc(C#N)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)CC2)CC1 CHEMBL3699240 IC50 0.93 nM
CCNc1nc(Nc2ccc3c(c2)c(C#N)nn3C2CCN(C3COC3)CC2)nn2c(C#N)cnc12 CHEMBL3699293 IC50 0.94 nM
CS(=O)(=O)CCN1CCN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)CC1 CHEMBL3699241 IC50 0.99 nM
O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 CHEMBL1230165 Kd apparent 1.0 nM
COC(=O)N[C@H]1CN(c2cc(C(F)F)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)C[C@H]1OC CHEMBL3699268 IC50 1.17 nM
[C-]#[N+]c1cnc2c(NC3CC3)nc(Nc3cc(C#N)cc(N4CCN(C5COC5)C(C(=O)N5CCOCC5)C4)c3Cl)nn12 CHEMBL3699279 IC50 1.32 nM
CN1C(C)(C)CC(Oc2cc(F)c(C#N)cc2Nc2nc(NC3CC3)c3ncc(C#N)n3n2)CC1(C)C CHEMBL3699300 IC50 1.43 nM
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(N2CCC(NC3CC(C#N)C3)CC2)c1 CHEMBL3699245 IC50 1.53 nM
COC(=O)N[C@@H]1CN(C2CCN(c3cc(C#N)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)CC2)C[C@@H]1C CHEMBL3699251 IC50 1.61 nM
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(C2CCN(CCC(F)(F)F)CC2)c1 CHEMBL3699265 IC50 2.05 nM
COc1cc(-c2cc(C(=O)N[C@H]3CCOC3)c3c(N)ncnn23)ccn1 CHEMBL3681206 IC50 2.2 nM
CCC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1C CHEMBL5283179 IC50 2.3 nM
[C-]#[N+]c1cnc2c(Nc3nc(C)n(C)n3)nc(Nc3ccc4c(c3)c(C#N)nn4C[C@@H](C)O)nn12 CHEMBL3699290 IC50 2.47 nM
COc1cc(-c2cc(C(=O)N[C@@H]3CCCN(C(=O)C4(N)CC4)C3)c3c(N)ncnn23)ccn1 CHEMBL3681201 IC50 2.5 nM
C[C@H](Nc1nc(Nc2cn(C)cn2)c2cc[nH]c2n1)c1ncc(F)cn1 CHEMBL3116050 IC50 2.7 nM
COc1cc(-c2cc(C(=O)N[C@H]3CC[C@H](NC(=O)C(C)(C)O)CC3)c3c(N)ncnn23)ccn1 CHEMBL3681202 IC50 2.7 nM
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(OC2CCNCC2)cc1F CHEMBL3699302 IC50 2.75 nM
CCOC(=O)NC1CCC(NC(=O)c2cc(-c3ccnc(OC)c3)n3ncnc(N)c23)CC1 CHEMBL3681194 IC50 2.8 nM
[C-]#[N+]c1cnc2c(NCC)nc(Nc3cc(C#N)cc(N4CC[C@@H](NC(=O)OC)[C@H](O)C4)c3Cl)nn12 CHEMBL3699281 IC50 2.95 nM
N#Cc1cnc2c(NC3CC3)nc(Nc3cc(C(F)F)cc(N4CCC(C5COC5)CC4)c3Cl)nn12 CHEMBL3699275 IC50 3.01 nM
N#Cc1cnc2c(NC3CC3)nc(Nc3cc(C(F)F)cc(N4CCN(C5(CS(=O)(=O)c6ccccc6)COC5)CC4)c3Cl)nn12 CHEMBL3699273 IC50 3.16 nM
COc1cc(-c2cc(C(=O)NC[C@H]3CC[C@H](O)CC3)c3c(N)ncnn23)ccn1 CHEMBL3681204 IC50 3.2 nM
N#Cc1cnc2c(NC3CC3)nc(Nc3cc(C(F)F)cc(N4CCN(C5(C#N)COC5)CC4)c3Cl)nn12 CHEMBL3699272 IC50 3.21 nM
COc1cc(-c2cc(C(=O)N[C@H]3CC[C@@H](CO)CC3)c3c(N)ncnn23)ccn1 CHEMBL3681203 IC50 3.4 nM
COc1cc(-c2cc(C(=O)N[C@H]3CC[C@H](NC(=O)C4(CN)CC4)CC3)c3c(N)ncnn23)ccn1 CHEMBL3681200 IC50 3.6 nM
COc1cc(-c2cc(C(=O)N[C@H]3CC[C@H](C(=O)O)CC3)c3c(N)ncnn23)ccn1 CHEMBL3681205 IC50 3.6 nM
COc1cc(-c2cc(C(=O)N[C@H]3CC[C@H](NC(=O)C(C)(C)CN4CCCC4)CC3)c3c(N)ncnn23)ccn1 CHEMBL3681208 IC50 3.7 nM
CCN1CCCC1CNC(=O)[C@H]1CC[C@H](NC(=O)c2cc(-c3ccnc(OC)c3)n3ncnc(N)c23)CC1 CHEMBL3681207 IC50 3.9 nM
[C-]#[N+]c1cnc2c(NCC)nc(Nc3cc(C(F)F)cc(N4CCN(C5COC5)CC4)c3Cl)nn12 CHEMBL3699288 IC50 4.53 nM
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)nc3)s2)cc1 CHEMBL3760043 IC50 4.6 nM
CN1CC(CN2CCN(c3cc(C(F)F)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)CC2)C1 CHEMBL3699271 IC50 4.72 nM
O=C1Nc2cc(CS(=O)(=O)c3c(Cl)cccc3Cl)ccc2S/C1=C\c1ccc(O)c([N+](=O)[O-])c1 CHEMBL5437737 IC50 5.0 nM
[C-]#[N+]c1cnc2c(NC3CC3)nc(Nc3nc(C#N)ncc3Cl)nn12 CHEMBL3699304 IC50 5.1 nM
COC1CN(C2CN(c3cc(C(F)F)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)C2)C1 CHEMBL3699270 IC50 5.96 nM
O=C(O)c1ccc2c(c1)nc(Nc1ccc3ccccc3c1)c1ncncc12 CHEMBL5288335 IC50 6.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 6.5 nM
COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1 CHEMBL3545083 Kd apparent 8.0 nM
CC(C)(C)[Si](C)(C)O[C@@H]1CC(N2CCC(c3cc(C#N)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)CC2)CC[C@H]1N CHEMBL3699263 IC50 8.18 nM
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3OCc3ccccc3F)s2)cc1 CHEMBL3759871 IC50 8.8 nM
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3OCc3ccccn3)s2)cc1 CHEMBL3758606 IC50 9.5 nM
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)nn3)s2)cc1 CHEMBL3758317 IC50 9.6 nM
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3OCc3ccccc3Cl)s2)cc1 CHEMBL3759512 IC50 9.8 nM
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cn3)s2)cc1 CHEMBL3759755 IC50 10.0 nM
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3Oc3ccccc3)s2)cc1 CHEMBL3758519 IC50 10.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 10.0 nM
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3)s2)cc1 CHEMBL2087023 IC50 11.0 nM
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3OCCc3ccccc3)s2)cc1 CHEMBL3760009 IC50 11.0 nM
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3OCc3ccccc3C#N)s2)cc1 CHEMBL3759349 IC50 11.0 nM
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3OCc3ccccc3)s2)cc1 CHEMBL3758270 IC50 12.0 nM
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3COc3ccccc3)s2)cc1 CHEMBL3760064 IC50 12.0 nM
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3OCc3ccccc3OC)s2)cc1 CHEMBL3758895 IC50 13.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 14.0 nM
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3OCc3ccccc3Br)s2)cc1 CHEMBL3758777 IC50 14.0 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 Kd apparent 15.0 nM
CC(C)NC1CCN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)CC1 CHEMBL3699243 IC50 15.53 nM
CC1(C)CC(Oc2cc(F)c(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)cc2C#N)CC(C)(C)N1 CHEMBL3699299 IC50 16.04 nM
O=C1NC(=O)/C(=C/c2ccc3nccc(-c4ccncc4)c3c2)S1 CHEMBL3544966 Kd apparent 17.0 nM
O=C(O)c1ccc2c(c1)nc(NCCc1cccc(Cl)c1)c1ccncc12 CHEMBL3700416 IC50 17.0 nM
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3OCc3ccc(Cl)cc3)s2)cc1 CHEMBL3759193 IC50 19.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 CHEMBL3301610 Kd apparent 19.0 nM
O=C(O)c1ccc2c(c1)nc(Nc1ccc(F)c(Cl)c1)c1ncncc12 CHEMBL1682280 IC50 19.0 nM
COc1cccc(CCNc2nc3cc(C(=O)O)ccc3c3cnccc23)c1 CHEMBL5289971 IC50 19.0 nM
CN1C(C)(C)CC(Oc2cc(F)c(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)cc2C#N)CC1(C)C CHEMBL3699298 IC50 19.71 nM
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(N2CCC(NCC(F)(F)F)CC2)c1 CHEMBL3699246 IC50 20.89 nM
Ic1c(I)c(I)c2[nH]cnc2c1I CHEMBL595730 Ki 21.0 nM
CN(C)c1nc2c(Br)c(Br)c(Br)c(Br)c2n1CC(=O)O CHEMBL1233807 Ki 21.0 nM
O=c1[nH]c(C2CCCN2)nc2c1oc1ccc(Cl)cc12 CHEMBL3544944 Kd apparent 22.0 nM
O=C(O)c1ccc2c(c1)nc(Nc1ccc3ccccc3c1)c1ccncc12 CHEMBL5287614 IC50 22.0 nM
Cn1c(SCC(=O)O)nc2c(Br)c(Br)c(Br)c(Br)c21 CHEMBL1928905 Ki 24.0 nM
COCCNC1CCN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)CC1 CHEMBL3699249 IC50 24.95 nM
O=C(O)c1ccc2c(c1)nc(Nc1ccc(Cl)cc1)c1ncncc12 CHEMBL5277426 IC50 25.0 nM
O=C(O)CCSc1nc2c(Br)c(Br)c(Br)c(Br)c2[nH]1 CHEMBL1928903 Ki 31.0 nM
O=C(O)c1ccc2c(c1)nc(NCCc1ccccc1)c1ccncc12 CHEMBL1652704 IC50 34.0 nM
CN(C)c1nc2c(Br)c(Br)c(Br)c(Br)c2n1C CHEMBL375230 Ki 35.0 nM
O=C(O)CSc1nc2c(Br)c(Br)c(Br)c(Br)c2[nH]1 CHEMBL223082 Ki 37.0 nM
CC(C)(C)OC(=O)N(CCOCCO)c1ccn2ncc(-c3ccc(C(=O)O)c(O)c3)c2n1 CHEMBL4793819 IC50 38.0 nM
O=C(O)c1ccc2c(c1)nc(Nc1ccccc1Cl)c1ncncc12 CHEMBL5288569 IC50 42.0 nM
O=C(O)c1ccc2c(c1)nc(Nc1ccc(F)c(Cl)c1)c1ccncc12 CHEMBL1652707 IC50 43.0 nM
O=C(O)CCCSc1nc2c(Br)c(Br)c(Br)c(Br)c2[nH]1 CHEMBL1928904 Ki 44.0 nM
CN1C(C)(C)CC(Oc2cc(OC3CC(C)(C)N(C)C(C)(C)C3)c(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)cc2C#N)CC1(C)C CHEMBL3699301 IC50 46.59 nM
Nc1ncnn2c(-c3ccnc(F)c3)cc(C(=O)N[C@H]3CC[C@H](O)CC3)c12 CHEMBL3681193 IC50 50.0 nM
Nc1ncnn2c(-c3ccncc3)cc(C(=O)N[C@H]3CC[C@@H](O)CC3)c12 CHEMBL3681220 IC50 50.0 nM
CC1CCN(C(=O)c2cc(-c3ccncc3)n3ncnc(N)c23)CC1 CHEMBL3681210 IC50 50.0 nM
COc1cc(-c2cc(C(=O)N[C@H]3CC[C@H](NC(=O)CC(C)(C)O)CC3)c3c(N)ncnn23)ccn1 CHEMBL3681199 IC50 50.0 nM
CC(=O)NC1CCC(NC(=O)c2cc(-c3ccncc3)n3ncnc(N)c23)CC1 CHEMBL3681197 IC50 50.0 nM
COc1cc(-c2cc(C(=O)N[C@H]3CC[C@H](OCC(C)(C)C)CC3)c3c(N)ncnn23)ccn1 CHEMBL3681209 IC50 50.0 nM
Nc1ncnn2c(-c3ccncc3)cc(C(=O)NCCc3ccccn3)c12 CHEMBL3681222 IC50 50.0 nM
O=C(O)c1ccc2c(c1)nc(Nc1cccc(F)c1)c1ncncc12 CHEMBL1682282 IC50 51.0 nM
Cn1c(SCCC(=O)O)nc2c(Br)c(Br)c(Br)c(Br)c21 CHEMBL1928906 Ki 55.0 nM
CC(C)(C)OC(=O)NCCCCCNC(=O)c1cc(-c2ccncc2)n2ncnc(N)c12 CHEMBL3681221 IC50 60.0 nM
Nc1ncnn2c(-c3ccncc3)cc(C(=O)NC3CCOCC3)c12 CHEMBL3681198 IC50 60.0 nM
COC(=O)N[C@@H]1CCN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)C[C@H]1OC CHEMBL3699261 IC50 61.21 nM
O=C(O)Cn1cnc2c(I)c(I)c(I)c(I)c21 CHEMBL593153 Ki 62.0 nM
O=C(O)c1ccc2c(c1)nc(NCCc1cccc(F)c1)c1ccncc12 CHEMBL3700417 IC50 62.0 nM
COc1ccc(C(=O)Nc2cc(-c3ccc(C(=O)O)cc3)[nH]n2)cc1 CHEMBL2087025 IC50 63.0 nM
O=C(O)c1ccc2c(c1)nc(Nc1ccccc1)c1ncncc12 CHEMBL5273686 IC50 63.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 65.0 nM
N#Cc1cccc(Nc2nc3cc(C(=O)O)ccc3c3cncnc23)c1 CHEMBL4846181 IC50 66.0 nM
CCOC(=O)N[C@H]1CC[C@H](NC(=O)c2cc(-c3ccncc3)n3ncnc(N)c23)CC1 CHEMBL3681195 IC50 70.0 nM
O=C(O)CSc1nc2c(I)c(I)c(I)c(I)c2[nH]1 CHEMBL610448 Ki 78.0 nM
[C-]#[N+]c1cnc2c(NC3CC3)nc(Nc3cccc(C#N)n3)nn12 CHEMBL3699283 IC50 81.62 nM
Cn1c(SCCCC(=O)O)nc2c(Br)c(Br)c(Br)c(Br)c21 CHEMBL1928907 Ki 83.0 nM
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(N2CCC(N(CC3CC3)CC3CC3)CC2)c1 CHEMBL3699248 IC50 85.66 nM
CN(C)c1nc2c(Br)c(Br)c(Br)c(Br)c2n1CCCC(=O)O CHEMBL1928909 Ki 93.0 nM
COc1cccc(CCNc2nc3cc(C(=O)O)ccc3c3cncnc23)c1 CHEMBL5273101 IC50 93.0 nM
O=C(O)c1ccc2c(c1)nc(NCCc1ccccc1)c1ncncc12 CHEMBL5279015 IC50 110.0 nM
CN(C)c1nc2c(Br)c(Br)c(Br)c(Br)c2[nH]1 CHEMBL376505 Ki 112.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 120.0 nM
O=C(O)c1ccc2c(c1)nc(Nc1ccc(Cl)cc1)c1ccncc12 CHEMBL1652710 IC50 130.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 140.0 nM
O=C(O)c1ccc2c(c1)nc(NCCc1cccc(Cl)c1)c1ncncc12 CHEMBL5272174 IC50 140.0 nM
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(N2CCC(NCC(F)F)CC2)c1 CHEMBL3699247 IC50 153.6 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 160.0 nM
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3OCc3cccc(Cl)c3)s2)cc1 CHEMBL3759388 IC50 160.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 180.0 nM
O=C(O)c1ccc2c(c1)nc(Nc1cccc(F)c1)c1ccncc12 CHEMBL1652708 IC50 180.0 nM
O=C(O)CCCn1cnc2c(Br)c(Br)c(Br)c(Br)c21 CHEMBL1928908 Ki 188.0 nM
O=C(O)Cc1ccn(-c2cncc(-n3ncc4ccc(NC5CCCC5)cc43)n2)c1 CHEMBL2048144 IC50 190.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 Kd 200.0 nM
O=C(O)c1ccc2c(c1)nc(NCc1ccccc1)c1ncncc12 CHEMBL5288779 IC50 200.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 230.0 nM
Brc1c(Br)c(Br)c2[nH]cnc2c1Br CHEMBL373937 Ki 270.0 nM
O=C(O)c1ccc2c(c1)nc(NCCc1cccc(F)c1)c1ncncc12 CHEMBL5284276 IC50 270.0 nM
CC1CC(=O)c2c3c(n(C(C)C)c2C1=O)-c1ccccc1C3=O CHEMBL5412868 IC50 273.0 nM
Cn1cc(-c2cnn3c(N)c(Br)c([C@@H]4CCCNC4)nc23)cn1 CHEMBL2386889 Kd apparent 279.0 nM
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)c4ccccc34)s2)cc1 CHEMBL3758475 IC50 280.0 nM
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL1078178 Kd apparent 302.0 nM
O=C(O)c1ccc2cc1OCCOCCNc1ccn3ncc-2c3n1 CHEMBL4795226 IC50 303.0 nM
Nc1ncnn2c(-c3ccnc(CCO)c3)cc(C(=O)NC3CCC(N)CC3)c12 CHEMBL3681219 IC50 330.0 nM
COc1cccc(Nc2nc3cc(C(=O)O)ccc3c3cnccc23)c1 CHEMBL1652706 IC50 340.0 nM
O=C(O)Cn1cnc2c(Br)c(Br)c(Br)c(Br)c21 CHEMBL594575 Ki 342.0 nM
CNCCCNC(=O)c1cc(-c2ccncc2)n2ncnc(N)c12 CHEMBL3681196 IC50 380.0 nM
C1=N/C2=N/c3ccc(OCCN4CCCC4)c(c3)COC/C=C/COCc3cccc(c3)C(=C1)N2 CHEMBL2035187 Kd apparent 394.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 Kd 400.0 nM
C=CCn1c(=O)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1cccc(C(C)(C)O)n1 CHEMBL1976040 Kd apparent 412.0 nM
O=C(O)c1ccc2c(c1)nc(Nc1ccccc1)c1ccncc12 CHEMBL1652697 IC50 420.0 nM
O=C(O)c1ccc2c(c1)nc(NCc1ccccc1)c1ccncc12 CHEMBL1652703 IC50 450.0 nM
CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O CHEMBL189963 Kd apparent 488.0 nM
CC(C)(C)C(OC(N)=O)C1CCN(C(=O)c2cc(-c3ccncc3)n3ncnc(N)c23)C1 CHEMBL3681211 IC50 560.0 nM
COc1cc(-c2cc(C(=O)N3CCC(O)CC3)c3c(N)ncnn23)ccn1 CHEMBL3681212 IC50 560.0 nM
c1cc(OCCN2CCCCC2)cc(-c2n[nH]c3ccc(-c4nnc[nH]4)cc23)c1 CHEMBL1614713 Kd apparent 584.0 nM
NCC1CCCN(C(=O)c2cc(-c3ccncc3)n3ncnc(N)c23)C1 CHEMBL3681213 IC50 670.0 nM
CC(C)Oc1cc(-c2cc(C(=O)NC3CCC(N)CC3)c3c(N)ncnn23)ccn1 CHEMBL3681218 IC50 700.0 nM
CN1CCCN(c2cncc(-c3cccc(/C=C/C(=O)O)c3)n2)CC1 CHEMBL493937 IC50 701.0 nM
CC(C)(C)N(CC1CCN(C(=O)c2cc(-c3ccncc3)n3ncnc(N)c23)CC1)C(=O)O CHEMBL3681214 IC50 750.0 nM
CC(C)(C)OC(=O)N1CCOCCOc2cc(ccc2C(=O)O)-c2cnn3ccc1nc23 CHEMBL4757618 IC50 771.0 nM
COc1cc(-c2cc(C(=O)N[C@H]3CC[C@H](O)CC3)c3c(N)ncnn23)ccc1C(N)=O CHEMBL3681216 IC50 790.0 nM
CN(CCCN)C(=O)c1cc(-c2ccncc2)n2ncnc(N)c12 CHEMBL3681215 IC50 810.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 890.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 940.0 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL3301622 Kd apparent 960.0 nM
C[C@@H](Oc1cc(-n2cnc3ccc(CN4CCN(C)CC4)cc32)sc1C(N)=O)c1ccccc1C(F)(F)F CHEMBL1908394 Kd 990.0 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL1084546 Kd apparent 998.0 nM
NC(=O)c1cccc(-c2cc(C(=O)N[C@H]3CC[C@H](O)CC3)c3c(N)ncnn23)c1 CHEMBL3681217 IC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM