O=C1NC(=O)/C(=C/c2cnn3c(NC4CC4)cc(-c4ccncc4)nc23)N1 CHEMBL3914148 IC50 48.7 nM
O=C1NC(=O)/C(=C/c2cnn3c(NC4CC4)cc(-c4cccc(OCC5=NCCN5)c4)nc23)N1 CHEMBL3919649 IC50 48.7 nM
O=C1NC(=O)/C(=C/c2cnn3c(NC4CC4)cc(-c4ccnc(F)c4)nc23)N1 CHEMBL3933287 IC50 75.4 nM
N#Cc1cccc(-c2cc(NC3CC3)n3ncc(/C=C4\NC(=O)NC4=O)c3n2)c1 CHEMBL3922569 IC50 75.4 nM
NCc1cccc(-c2cc(NC3CC3)n3ncc(/C=C4\SC(=O)NC4=O)c3n2)c1 CHEMBL3928114 IC50 197.8 nM
O=C1NC(=O)/C(=C/c2cnn3c([S+]([O-])Cc4ccccc4)cc(-c4cccc(Cl)c4)nc23)N1 CHEMBL3981518 IC50 209.0 nM
O=C1NC(=O)/C(=C/c2cnn3c(NC4CC4)cc(-c4ccnc(F)c4)nc23)S1 CHEMBL3954706 IC50 217.6 nM
N[C@H]1CC[C@H](Nc2cc(NC3CC3)n3ncc(/C=C4\NC(=O)NC4=O)c3n2)CC1 CHEMBL3976484 IC50 253.2 nM
CN(C)c1ccc(-c2cc(NC3CC3)n3ncc(/C=C4\NC(=O)NC4=O)c3n2)cn1 CHEMBL3910845 IC50 256.2 nM
O=C1NC(=O)/C(=C/c2cnn3c(NC4CC4)cc(-c4cccc(OCC5CC5)c4)nc23)N1 CHEMBL3978501 IC50 256.2 nM
O=C1NC(=O)/C(=C/c2cnn3c(NCC4CC4)cc(NN4CCOCC4)nc23)N1 CHEMBL3893330 IC50 284.1 nM
O=C1NC(=O)/C(=C/c2cnn3c(SCc4ccccc4)cc(-c4cccc(Cl)c4)nc23)N1 CHEMBL3927192 IC50 291.3 nM
O=C1NC(=O)/C(=C/c2cnn3c([S+]([O-])Cc4ccccc4)cc(Nc4cccc(Cl)c4)nc23)N1 CHEMBL3954928 IC50 296.8 nM
C[C@H](Nc1nc(NC2CC2)n2ncc(/C=C3\NC(=O)NC3=O)c2n1)c1ccc(C(F)(F)F)cc1 CHEMBL3955320 IC50 313.9 nM
CC(O)CNc1cc(Nc2cccc(Cl)c2)nc2c(/C=C3\NC(=O)NC3=O)cnn12 CHEMBL3917668 IC50 316.5 nM
O=C1NC(=O)/C(=C/c2cnn3c(NC4CCCC4)cc(Nc4cccc(Cl)c4)nc23)N1 CHEMBL3947068 IC50 342.6 nM
O=C1NC(=O)/C(=C/c2cnn3c(NC4CC4)cc(N4CCC(F)(F)CC4)nc23)N1 CHEMBL3977510 IC50 359.0 nM
O=C1NC(=O)/C(=C/c2cnn3c(NCc4ccccn4)cc(Nc4cccc(Cl)c4)nc23)N1 CHEMBL3940234 IC50 421.1 nM
CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O CHEMBL189963 Kd 448.0 nM
CCOCCNc1cc(Nc2cccc(Cl)c2)nc2c(/C=C3\NC(=O)NC3=O)cnn12 CHEMBL3976346 IC50 469.0 nM
O=C1NC(=O)/C(=C/c2cnn3c(NCCO)cc(Nc4cccc(Cl)c4)nc23)N1 CHEMBL3889467 IC50 474.7 nM
CS(=O)(=O)N[C@H]1CC[C@H](Nc2cc(NC3CC3)n3ncc(/C=C4\NC(=O)NC4=O)c3n2)CC1 CHEMBL3920670 IC50 476.0 nM
CC(=O)NC1CCC(Nc2cc(NC3CC3)n3ncc(/C=C4\NC(=O)NC4=O)c3n2)CC1 CHEMBL3984084 IC50 476.0 nM
O=C1NC(=O)/C(=C/c2cnn3c(NCC4CC4)cc(Nc4cccc(Cl)c4)nc23)N1 CHEMBL3930582 IC50 508.7 nM
C[C@@H](Nc1cc(Nc2cccc(Cl)c2)nc2c(/C=C3\NC(=O)NC3=O)cnn12)C1CC1 CHEMBL4108016 IC50 514.9 nM
CN(C)C(=O)N[C@H]1CC[C@H](Nc2cc(NC3CC3)n3ncc(/C=C4\NC(=O)NC4=O)c3n2)CC1 CHEMBL3957145 IC50 538.5 nM
O=C1NC(=O)/C(=C/c2cnn3c(NC4CC4)cc(-c4csc(C(=O)NC5CC5)c4)nc23)N1 CHEMBL3897318 IC50 548.0 nM
N[C@@H]1CCN(C(=O)c2cc(-c3cc(NC4CC4)n4ncc(/C=C5\NC(=O)NC5=O)c4n3)cs2)C1 CHEMBL4112371 IC50 608.4 nM
O=C1NC(=O)/C(=C/c2cnn3c(NC4CC4)cc(-c4cccc(O)c4)nc23)N1 CHEMBL3921643 IC50 613.5 nM
O=C1NC(=O)/C(=C/c2cnn3c(NC4CC4)cc(-c4cccc(CO)c4)nc23)N1 CHEMBL3963062 IC50 649.2 nM
CS(=O)(=O)c1cccc(-c2cc(NC3CC3)n3ncc(/C=C4\NC(=O)NC4=O)c3n2)c1 CHEMBL3909908 IC50 649.2 nM
CN1CCCC1CCNC(=O)c1cc(-c2cc(NC3CC3)n3ncc(/C=C4\NC(=O)NC4=O)c3n2)cs1 CHEMBL3957320 IC50 654.0 nM
COC(=O)N[C@H]1CC[C@H](Nc2cc(NC3CC3)n3ncc(/C=C4\NC(=O)NC4=O)c3n2)CC1 CHEMBL3926144 IC50 679.1 nM
O=C1NC(=O)/C(=C/c2cnn3c(NC4CCNC4)cc(Nc4cccc(Cl)c4)nc23)N1 CHEMBL3947780 IC50 700.8 nM
O=C1NC(=O)/C(=C/c2cnn3c(NCc4cccnc4)cc(Nc4cccc(Cl)c4)nc23)N1 CHEMBL3912234 IC50 704.1 nM
O=C1NC(=O)/C(=C/c2cnn3c(NC4CC4)cc(N4CC[C@@H](F)C4)nc23)N1 CHEMBL4112180 IC50 707.6 nM
O=C1NC(=O)/C(=C/c2cnn3c(NC4CC4)cc(-c4ccc(C(=O)N5CC(F)C5)s4)nc23)N1 CHEMBL3935654 IC50 713.7 nM
C[C@H](Nc1cc(NC2CC2)n2ncc(/C=C3\NC(=O)NC3=O)c2n1)C1CC1 CHEMBL3912472 IC50 765.9 nM
CN1CCC(NC(=O)c2ccc(-c3cc(NC4CC4)n4ncc(/C=C5\NC(=O)NC5=O)c4n3)s2)CC1 CHEMBL3919262 IC50 793.9 nM
CCN(CC)CCCC(C)NC(=O)c1ccc(-c2cc(NC3CC3)n3ncc(/C=C4\NC(=O)NC4=O)c3n2)s1 CHEMBL3949243 IC50 810.6 nM
CN(C)C1CCN(Cc2ccc(-c3cc(NC4CC4)n4ncc(/C=C5\NC(=O)NC5=O)c4n3)s2)C1 CHEMBL3929991 IC50 810.6 nM
CN(C)CC(C)(C)CNC(=O)c1cc(-c2cc(NC3CC3)n3ncc(/C=C4\NC(=O)NC4=O)c3n2)cs1 CHEMBL3896234 IC50 813.3 nM
COc1cccc(-c2cc(NC3CC3)n3ncc(/C=C4\SC(=O)NC4=O)c3n2)c1 CHEMBL3894505 IC50 815.2 nM
O=Cc1cnn2c(NC3CC3)cc(NC3CCCC3)nc12 CHEMBL3953595 IC50 845.3 nM
CN(C)c1ccc(-c2cc(NC3CC3)n3ncc(/C=C4\NC(=O)NC4=O)c3n2)cc1 CHEMBL3894469 IC50 867.0 nM
O=C1NC(=O)/C(=C/c2cnn3c(NC4CC4)cc(-c4cccc(NS(=O)(=O)C5CC5)c4)nc23)N1 CHEMBL3894819 IC50 867.0 nM
CN(C)c1cc(NC2CC2)n2ncc(/C=C3\SC(=O)NC3=O)c2n1 CHEMBL3896470 IC50 875.9 nM
O=C1NC(=O)/C(=C/c2cnn3c(NC4CC4)cc(NC4CCNCC4)nc23)N1 CHEMBL3947407 IC50 877.1 nM
C[C@@H]1CN(C(=O)c2cc(-c3cc(NC4CC4)n4ncc(/C=C5\NC(=O)NC5=O)c4n3)cs2)C[C@H](C)N1 CHEMBL3929751 IC50 888.0 nM
O=C1NC(=O)/C(=C/c2cnn3c(NC4CC4)cc(-c4cccc(OC(F)(F)F)c4)nc23)N1 CHEMBL3894485 IC50 890.8 nM
O=C1NC(=O)/C(=C/c2cnn3c(NC4CC4)cc(-c4csc(C(=O)NCCN5CCCC5)c4)nc23)N1 CHEMBL3976827 IC50 982.0 nM
O=C1NC(=O)/C(=C/c2cnn3c(NC4CC4)cc(NCC4CC4)nc23)N1 CHEMBL3982380 IC50 997.8 nM
O=C(O)c1ccc(Nc2nc(-c3ccc4ccccc4c3)cs2)cc1O CHEMBL4520531 IC50 1000.0 nM