CC[C@H](C)[C@H](NC(=O)NNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)OC)C(C)C CHEMBL2028921 Ki 0.03 nM
C[C@@H](CC1CCCCC1)OC(=O)NN(C)C#N CHEMBL190121 Ki 0.077 nM
CC[C@H](C)[C@H](NC(=O)NNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)C(C)C)C(=O)N[C@H](C(=O)OC)C(C)C CHEMBL2028907 Ki 0.088 nM
CC(C)C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)NNC(=O)N[C@H](C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C CHEMBL2028909 Ki 0.12 nM
CC[C@H](C)[C@H](NC(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)OC)C(C)C CHEMBL2028910 Ki 0.13 nM
CC[C@H](C)[C@H](NC(=O)NNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C CHEMBL2028919 Ki 0.25 nM
CC[C@@H](Cc1ccccc1)OC(=O)NN(C)C#N CHEMBL191558 Ki 0.25 nM
CC[C@H](C)[C@H](NC(=O)NNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1)[C@@H](C)CC)C(=O)N[C@H](C(=O)OC)C(C)C CHEMBL2028911 Ki 0.3 nM
CC(C)C[C@H](NC(=O)c1ccc(-c2noc(-c3cccs3)n2)cc1)C(=O)N(C)N(C)C#N CHEMBL1651361 Ki 0.36 nM
CN(C#N)N(C)C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1 CHEMBL1651353 Ki 0.38 nM
CC(C)(C)OC(=O)NN(C#N)CC(=O)N(Cc1ccccc1)Cc1ccccc1 CHEMBL3342185 Ki 0.406 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N(C)N(C)C#N CHEMBL608115 Ki 0.43 nM
CN(Cc1ccccc1)C(=O)CN(C#N)NC(=O)OC(C)(C)C CHEMBL3342184 Ki 0.459 nM
CN(C#N)N(C)C(=O)[C@H](CC1CCCCC1)NC(=O)OCc1ccccc1 CHEMBL1651352 Ki 0.48 nM
CC(C)C[C@H](NC(=O)NCc1ccccc1)C(=O)N(C)N(C)C#N CHEMBL1651354 Ki 0.65 nM
CN(C#N)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 CHEMBL604281 Ki 0.68 nM
CC(C)CC(NC(=O)c1ccc(-c2ccc(-c3ccccc3)cc2)cc1)C(=O)N(C)N(C)C#N CHEMBL4442025 Ki 0.69 nM
CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N(C)N(C)C#N CHEMBL1651351 Ki 0.88 nM
CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)O CHEMBL314442 Ki 1.0 nM
Cc1cccc(O[C@H]2CCN3C[C@H]2OC3=O)c1C CHEMBL390474 IC50 1.0 nM
CC(C)N(C#N)NC(=O)O[C@@H](C)CC1CCCCC1 CHEMBL371420 Ki 1.3 nM
CC(C)C[C@H](NC(=O)Nc1ccccc1)C(=O)N(C)N(C)C#N CHEMBL1651355 Ki 1.3 nM
CC(C)C[C@H](NC(=O)NCc1ccc(-c2noc(-c3cccs3)n2)cc1)C(=O)N(C)N(C)C#N CHEMBL1651357 Ki 1.3 nM
CC[C@H](C)[C@H](NC(=O)NNC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)OC)C(C)C CHEMBL2028912 Ki 1.41 nM
CC[C@H](C)[C@H](NC(=O)NNC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)OC)C(C)C CHEMBL2028920 Ki 1.58 nM
CCC[C@H](NC(=O)[C@@H]1[C@H]2CCC[C@H]2CN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1cnccn1)C(C)C)C(C)(C)C)C(=O)C(=O)NC1CC1 CHEMBL86453 Ki 1.6 nM
Cc1cccc(C[C@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C#N)COCc2cccc(C(=O)O)c2)c1 CHEMBL336228 IC50 1.8 nM
Cc1cccc(C[C@H](NC(=O)c2ccc(Cl)cc2F)C(=O)N[C@H](C#N)COCc2cccc(C(=O)O)c2)c1 CHEMBL138499 IC50 2.0 nM
CCC[C@H](NC(=O)[C@H](CC(C)C)C(=O)OCc1ccccc1)C(=O)c1nnc(-c2ccco2)o1 CHEMBL207347 Ki app 2.0 nM
O=C1O[C@@H]2CN1CC[C@@H]2OCc1ccccc1 CHEMBL390475 IC50 2.0 nM
CCCC[C@H](NC(=O)C(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)c1nnc(-c2ccco2)o1 CHEMBL271004 Ki 2.0 nM
CC(C)CC(NC(=O)c1ccc(Br)cc1)C(=O)N(C)N(C)C#N CHEMBL4440655 Ki 2.0 nM
CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)[C@@H](C)CC CHEMBL490920 IC50 2.24 nM
CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)[C@@H](C)CC CHEMBL4533469 IC50 2.28 nM
C[C@@H](CC1CCCCC1)OC(=O)C1CCN1C#N CHEMBL183812 IC50 2.4 nM
Cc1nc(-c2ccc(NC(=O)N[C@@H](CC(C)C)C(=O)N(C)N(C)C#N)cc2)no1 CHEMBL1651349 Ki 2.4 nM
CC(C)C[C@H](NC(=O)Nc1ccc(-c2noc(-c3cccs3)n2)cc1)C(=O)N(C)N(C)C#N CHEMBL1651350 Ki 2.4 nM
Cc1nc(-c2ccc(CNC(=O)N[C@@H](CC(C)C)C(=O)N(C)N(C)C#N)cc2)no1 CHEMBL1651356 Ki 2.8 nM
CC(C)C[C@@H](NC(=O)N1CCOCC1)C(=O)N[C@@H](/C=C/S(=O)(=O)c1ccccc1)CCc1ccccc1 CHEMBL222649 IC50 3.0 nM
CC(=O)c1c(Nc2ccc(C(C)(C)C)cc2)[nH]c2c(Cl)cc([N+](=O)[O-])cc2c1=O CHEMBL521636 IC50 3.11 nM
CC(C)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H]1O[C@@H]1C(=O)O CHEMBL418661 Ki 3.36 nM
CC(C)(C)OC(=O)NN(C#N)CC(=O)N1CCOCC1 CHEMBL3342183 Ki 3.56 nM
CCC[C@H](NC(=O)[C@@H]1[C@H]2CCC[C@H]2CN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1cnccn1)C(C)C)C(C)(C)C)C(=O)C(=O)NC(C)CC CHEMBL314777 Ki 3.7 nM
CCCC(NC(=O)[C@@H]1[C@H]2CCC[C@H]2CN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1cnccn1)C(C)C)C(C)C)C(=O)C(=O)NC1CC1 CHEMBL264623 Ki 4.0 nM
CS(=O)(=O)N[C@H](COCc1ccccc1)C(=O)N[C@H](C=O)CCCCNS(=O)(=O)c1ccccc1 CHEMBL89100 Ki 4.0 nM
Cc1cccc(C[C@H](Nc2ccc3c(c2)C(=O)OC3)C(=O)N[C@H](C#N)COCc2ccc(F)c(C(=O)O)c2)c1 CHEMBL131688 IC50 4.1 nM
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N(C)N(C)C#N CHEMBL1651242 Ki 4.3 nM
CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(=O)O)C(=O)NCCCCN=C(N)N CHEMBL374508 IC50 4.6 nM
Cc1cccc(C[C@H](Nc2ccc3c(c2)C(=O)N(C)C3=O)C(=O)N[C@H](C#N)COCc2cccc(C(=O)O)c2)c1 CHEMBL133728 IC50 4.9 nM
CC(C)[C@H](NC(=O)c1cnccn1)C(=O)N[C@H](C(=O)N1C[C@@H]2CCC[C@@H]2[C@H]1C(=O)N[C@@H](CC(F)F)C(=O)C(=O)NC1CC1)C(C)(C)C CHEMBL313182 Ki 5.0 nM
Cc1cccc(C[C@H](Nc2ccc3c(c2)C(=O)OC3)C(=O)N[C@H](C#N)COCc2cccc(-n3cnnn3)c2)c1 CHEMBL335426 IC50 5.0 nM
O=C1O[C@@H]2CN1CC[C@@H]2Oc1ccccc1 CHEMBL230474 IC50 5.0 nM
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCCNC(=N)N CHEMBL191881 Ki 5.0 nM
CC(C)CC(NC(=O)c1cccc(-c2ccncc2)c1)C(=O)N(C)N(C)C#N CHEMBL4459206 Ki 5.0 nM
C[C@@H](OCc1ccccc1)[C@@H](C#N)NC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)c1cccc(-c2cccnc2)c1 CHEMBL4746374 pKi 5.012 nM
Cc1cccc(C[C@H](Nc2ccc3c(c2)C(=O)OC3(C)C)C(=O)N[C@H](C#N)COCc2cccc(C(=O)O)c2)c1 CHEMBL131732 IC50 5.3 nM
Cc1cccc(C[C@H](Nc2ccc3c(c2)C(=O)CC3)C(=O)N[C@H](C#N)COCc2cccc(C(=O)O)c2)c1 CHEMBL437251 IC50 5.3 nM
Cc1cccc(C[C@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C#N)CC#Cc2cccc(C(=O)O)c2)c1 CHEMBL344035 IC50 5.6 nM
CN1CCN(C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](/C=C/S(=O)(=O)c2ccccc2)CCc2ccccc2)CC1 CHEMBL91704 IC50 5.7 nM
CC(C)CS(=O)(=O)C[C@H](NC(=O)c1ccccc1)C(=O)N(C)N(C)C#N CHEMBL2153161 Ki 5.8 nM
CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)B(O)O CHEMBL114388 Ki 6.1 nM
Cc1cccc(C[C@H](Nc2ccc3c(c2)C(=O)OC3)C(=O)N[C@H](C#N)COCc2cccc(C(=O)O)c2)c1 CHEMBL336539 IC50 6.5 nM
Cc1cccc(C[C@H](NC(=O)c2ccc(F)cc2F)C(=O)N[C@H](C#N)COCc2cccc(C(=O)O)c2)c1 CHEMBL134083 IC50 6.8 nM
CC(C)[C@@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)CNc1ccc(N2CCCCC2)cc1 CHEMBL171403 Ki 7.0 nM
CC(C)C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)NNC(=O)N[C@@H](C)C(=O)NCC(N)=O)C(C)C CHEMBL2028908 Ki 7.29 nM
CC[C@H](C)[C@@H](C(=O)O[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)/C=C/C(=O)N1C(=O)C=C(OC)[C@@H]1C)N(C)C CHEMBL541700 IC50 7.34 nM
CC(C)CO[C@H]1CCN2C[C@H]1OC2=O CHEMBL230478 IC50 8.0 nM
C[C@@H](/C=C/[N+](=O)[O-])NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 CHEMBL3907022 Ki 8.0 nM
COC(=O)c1cccc(N[C@@H](Cc2cccc(C)c2)C(=O)N[C@H](C#N)COCc2cccc(C(=O)O)c2)c1 CHEMBL336115 IC50 8.6 nM
Cc1cccc(C[C@H](Nc2ccccc2)C(=O)N[C@H](C#N)COCc2ccc(Cl)c(C(=O)O)c2)c1 CHEMBL334879 IC50 8.7 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccc(C#N)cc1F CHEMBL1288523 IC50 9.0 nM
Cc1cccc(C[C@H](Nc2ccc3c(c2)C(=O)N(C)C3)C(=O)N[C@H](C#N)COCc2cccc(C(=O)O)c2)c1 CHEMBL335407 IC50 9.3 nM
Cc1cccc(C[C@H](NC(=O)c2ccccc2)C(=O)N[C@H](C#N)COCc2cccc(C(=O)O)c2)c1 CHEMBL337090 IC50 9.4 nM
Cc1cccc(C[C@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C#N)COCc2ccccc2)c1 CHEMBL336436 IC50 10.2 nM
Cc1cccc(C[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](C#N)COCc2ccccc2)c1 CHEMBL468202 Activity 10.2 nM
CC(C)C(NC(=O)OCc1ccccc1)C(=O)N1CCCCN1C#N CHEMBL493039 IC50 11.0 nM
Cc1cc(C)cc(C[C@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCC#N)c1 CHEMBL138661 IC50 11.9 nM
Cc1ccc(C[C@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCC#N)cc1C CHEMBL4582255 IC50 11.9 nM
CSCC[C@@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)CNc1ccc(N2CCCCC2)cc1 CHEMBL172456 Ki 12.0 nM
CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL64925 Ki app 12.0 nM
Cc1cccc(C[C@H](Nc2ccccc2)C(=O)N[C@H](C#N)COCc2ccc(F)c(C(=O)O)c2)c1 CHEMBL133107 IC50 12.2 nM
C[C@@H](OCc1ccccc1)[C@@H](C#N)NC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)c1ccc(Br)cc1 CHEMBL4757831 pKi 12.59 nM
C[C@@H](OCc1ccccc1)[C@@H](C#N)NC(=O)[C@H](Cc1cccc(Br)c1)NC(=O)c1ccc(-c2cccnc2)cc1 CHEMBL4749112 pKi 12.59 nM
C[C@@H](OCc1ccccc1)[C@@H](C#N)NC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)c1ccc(-c2cncnc2)cc1 CHEMBL4760236 pKi 12.59 nM
C[C@@H](OCc1ccccc1)[C@@H](C#N)NC(=O)[C@H](Cc1cccc(Br)c1)NC(=O)c1ccc(-c2cncnc2)cc1 CHEMBL4784909 pKi 12.59 nM
CC[C@H](C)[C@H](NC(=O)NNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC)C(C)C CHEMBL2028906 Ki 13.0 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@H]1CC[C@@H](C)N(S(=O)(=O)c2ccccn2)CC1=O CHEMBL203665 Ki app 13.0 nM
CCCC[C@H](NC(=O)O[C@H](Cn1ccc(-c2ccncc2)n1)C(C)(C)C)C(=O)CNS(=O)(=O)c1ccccn1 CHEMBL393354 IC50 13.0 nM
Cc1cccc(C[C@H](Nc2cccc(S(C)(=O)=O)c2)C(=O)N[C@H](C#N)COCc2cccc(C(=O)O)c2)c1 CHEMBL133744 IC50 13.3 nM
CC(=O)c1c(Nc2ccc(Cl)cc2)[nH]c2c(Cl)cc([N+](=O)[O-])cc2c1=O CHEMBL492175 IC50 14.2 nM
CCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NC1CCCCC1 CHEMBL3359772 IC50 16.0 nM
Cc1cccc(C[C@H](Nc2ccccc2)C(=O)N[C@H](C#N)COCc2cccc(-n3cnnn3)c2)c1 CHEMBL334631 IC50 16.5 nM
Cc1cccc(C[C@H](NC(=O)c2ccc(Cl)cc2F)C(=O)N[C@H](C#N)COCc2ccccc2)c1 CHEMBL140506 IC50 16.9 nM
CN1CCN(c2nc(-c3ccc(C(=O)NC4(C(=O)NCC#N)CCCCC4)cc3)cs2)CC1 CHEMBL426819 IC50 17.0 nM
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)O CHEMBL418606 IC50 17.7 nM
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)NC(C=O)Cc1ccccc1 CHEMBL423112 Ki 18.0 nM
Cc1cccc(C[C@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C#N)CCCc2cccc(C(=O)O)c2)c1 CHEMBL343759 IC50 18.0 nM
CCCC[C@@H](/C=N/NC(=O)N1CCOCC1)NC(=O)O[C@H](Cc1ccccc1)C(C)C CHEMBL203663 IC50 18.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)OCC(F)(F)F)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL231865 IC50 19.0 nM
N#C[C@H](COCc1cn(CC(=O)O)nn1)NC(=O)[C@H](Cc1cccc(Br)c1)NC(=O)c1ccc(-c2ccccc2)cc1 CHEMBL3805093 Ki 19.2 nM
CC(C)C(C(=O)N[C@H](C=O)Cc1ccccc1)C(=O)OCc1ccccc1 CHEMBL206243 Ki 20.0 nM
CCCC[C@H](NC(=O)O[C@H](Cn1ccc(-c2ccc(C(F)(F)F)cc2)n1)C(C)(C)C)C(=O)C(=O)Nc1ccn[nH]1 CHEMBL234367 IC50 20.0 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL231863 IC50 20.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(N)=O CHEMBL3359790 IC50 20.0 nM
CS(=O)(=O)N[C@H](Cc1cccs1)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL88895 Ki 23.0 nM
CC[C@@H](C)[C@H](NS(=O)(=O)c1ccc2ccccc2c1)C(=O)N[C@@H](C=O)Cc1c[nH]c2ccccc12 CHEMBL1791004 IC50 23.0 nM
CC(C)C(Nc1cccc(C(F)(F)F)c1)C(=O)N1CCCCN1C#N CHEMBL521987 IC50 23.0 nM
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL286722 Ki 24.0 nM
O=C(N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H]1CCCN(S(=O)(=O)c2ccccn2)CC1=O)c1cc2ccccc2o1 CHEMBL194861 Ki app 24.0 nM
C[C@@H](OCc1ccccc1)[C@@H](C#N)NC(=O)[C@H](Cc1cccc(Cl)c1)NS(=O)(=O)c1cccc(-c2ccccc2)c1 CHEMBL4758951 pKi 25.12 nM
CC(C)C[C@H](Nc1ccc(-c2ccc(N3CCNCC3)cc2)cc1)C(=O)NCC#N CHEMBL184859 IC50 26.0 nM
COC(=O)Cn1cc(COC[C@@H](C#N)NC(=O)[C@H](Cc2cccc(Br)c2)NC(=O)c2ccc(-c3ccccc3)cc2)nn1 CHEMBL3805885 Ki 26.0 nM
CCCCC(NC(=O)c1ccccc1/C=C/c1ccc(CN(C)C)cc1)C(N)=O CHEMBL77784 Ki 27.0 nM
CCCC[C@@H](C=O)NC(=O)O[C@H](Cc1ccccc1)C(C)C CHEMBL113948 IC50 27.0 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(C3(C(N)=O)CC3)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccccc1 CHEMBL1288525 IC50 27.0 nM
COc1ccc2c(O[C@@H]3C[C@H](C(=O)N[C@@H](CC4CC4)C(=O)C(=O)NC4CC4)N(C[C@@H](NC(=O)NC(C)(C)C)C(C)(C)C)C3)nccc2c1 CHEMBL4092255 IC50 27.0 nM
CCN(CC)Cc1ccc(/C=C/c2ccccc2C(=O)NC(Cc2ccccc2)C(=O)C(N)=O)cc1 CHEMBL4066494 Ki 28.0 nM
CCN(CC)c1ccc(/C=C/c2ccccc2C(=O)NC(Cc2ccccc2)C(=O)C(N)=O)cc1 CHEMBL5195850 Ki 28.0 nM
Cc1cccc(C[C@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C#N)COCc2cccc(CO)c2)c1 CHEMBL343423 IC50 29.0 nM
CCCCNC(=O)C(=O)[C@H](CCC)NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1 CHEMBL3649393 IC50 29.4 nM
CC(C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@@H](C=O)Cc1c[nH]c2ccccc12 CHEMBL136252 IC50 30.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCCc1ccccc1 CHEMBL3649410 IC50 30.2 nM
Cc1cccc(C[C@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C#N)COCc2ccc(C(=O)O)cc2)c1 CHEMBL336458 IC50 30.7 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCc1ccccc1 CHEMBL3649396 IC50 31.0 nM
Cc1cccc(C[C@H](NC(=O)c2ccc(Cl)c(Cl)c2)C(=O)NCC#N)c1 CHEMBL336474 IC50 31.3 nM
C[C@@H](OCc1ccccc1)[C@@H](C#N)NC(=O)[C@H](Cc1cccc(Br)c1)NC(=O)c1cccc(-c2cccnc2)c1 CHEMBL4741290 pKi 31.62 nM
C[C@@H](OCc1ccccc1)[C@@H](C#N)NC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)c1ccc(-c2ccccc2)cc1 CHEMBL4762161 pKi 31.62 nM
CS(=O)(=O)N[C@H](COCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL315636 Ki 32.0 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@@H]1C(=O)CN(S(=O)(=O)c2ccccn2)CC[C@@H]1C CHEMBL202668 Ki app 32.0 nM
Cc1cccc(NC(C(=O)N2CCCCN2C#N)C(C)C)c1 CHEMBL493038 IC50 32.0 nM
CC(C)C(Nc1cccc(Cl)c1)C(=O)N1CCCCN1C#N CHEMBL492619 IC50 32.0 nM
N#Cc1nc(Nc2cccc([N+](=O)[O-])c2)nc(N2CCNCC2)n1 CHEMBL3893204 IC50 34.0 nM
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H](/C=C/[N+](=O)[O-])CCc1ccccc1)OCc1ccccc1 CHEMBL3974129 Ki 34.0 nM
CCCCC(=O)N[C@@H](Cc1cccc(C)c1)C(=O)N[C@H](C#N)COCc1cccc(C(=O)O)c1 CHEMBL141793 IC50 35.7 nM
O=C[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@@H](OS(=O)(=O)c2ccccc2)CN1S(=O)(=O)c1ccccc1 CHEMBL87146 IC50 38.0 nM
CC(C)C(NC(=O)OC(C)(C)C)C(=O)N1CCCCN1C#N CHEMBL493018 IC50 38.0 nM
C[C@@H](OCc1ccccc1)[C@@H](C#N)NC(=O)[C@H](Cc1cccc(Br)c1)NC(=O)c1ccc(-c2ccccc2)cc1 CHEMBL4784441 IC50 39.4 nM
C[C@@H](OCc1ccccc1)[C@@H](C#N)NC(=O)[C@H](Cc1cccc(Cl)c1)NS(=O)(=O)c1cccc(Br)c1 CHEMBL4755248 pKi 39.81 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)NNC(=O)N[C@H](C(=O)OCc1ccccc1)C(C)C)C(C)C CHEMBL3143135 Ki 40.0 nM
CCNC(=O)C(=O)[C@H](Cc1ccc(Br)cc1)NC(=O)[C@@H](NC(=O)CCCCC1CCSS1)C(C)C CHEMBL200283 IC50 40.0 nM
CCCC[C@H](NC(=O)O[C@H](Cn1cnc2cc(Cl)c(Cl)cc21)C(C)(C)C)C(=O)CNS(=O)(=O)c1ccccn1 CHEMBL232713 IC50 40.0 nM
Cc1cc(C)cc(CC(NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCC#N)c1 CHEMBL477531 IC50 40.0 nM
CC(C)C(Nc1cccc(C#N)c1)C(=O)N1CCCCN1C#N CHEMBL502439 IC50 40.0 nM
CS(=O)(=O)N[C@H](CSCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL92114 Ki 41.0 nM
CC(C)[C@H](N[C@@H](c1ccc(-c2ccc(C3(C(N)=O)CC3)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccc(C#N)cc1F CHEMBL1288531 IC50 41.0 nM
Cc1cccc(C[C@H](NC(=O)c2ccc(F)cc2F)C(=O)N[C@H](C#N)COCc2ccccc2)c1 CHEMBL140606 IC50 42.0 nM
Cc1cccc(C[C@H](NC(=O)c2ccc(F)cc2)C(=O)N[C@H](C#N)COCc2cccc(C(=O)O)c2)c1 CHEMBL5411088 Ki 42.0 nM
CCOC(=O)CCSCC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 CHEMBL161817 Ki 42.7 nM
CC(C)C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C CHEMBL2028913 Ki 43.0 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649370 IC50 43.3 nM
CC(OCc1ccccc1)[C@@H](NS(C)(=O)=O)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL89766 Ki 44.0 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CCCC2)CC1)C(=O)NC1(C#N)CC1 CHEMBL3640708 Ki 44.0 nM
CS(=O)(=O)N[C@H](COCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccc(OCc2ccccc2)cc1 CHEMBL91991 Ki 45.0 nM
CCS(=O)(=O)N[C@H](COCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL89008 Ki 45.0 nM
CC(C)(C)SCC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 CHEMBL161651 Ki 45.0 nM
Cc1cccc(C[C@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCC#N)c1 CHEMBL140756 IC50 45.0 nM
COc1ccc(Nc2nc(C#N)nc(N3CCNCC3)n2)cc1 CHEMBL3930949 IC50 45.0 nM
C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)O CHEMBL430922 IC50 45.1 nM
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)CSCCCc1ccccc1)OCc1ccccc1 CHEMBL103238 Ki 45.4 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Br)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649377 IC50 45.4 nM
CC(C)C[C@@H](CN1CC(=O)C(NC(=O)[C@H](CC(C)C)NC(=O)c2ccc3cccnc3c2)C1)NC(=O)OCc1ccccc1 CHEMBL350591 Ki app 46.0 nM
Cc1cccc(O[C@H]2CCN3C[C@@H]2OC3=O)c1C CHEMBL230473 IC50 46.0 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CCCCC2)CC1)C(=O)NC1(C#N)CC1 CHEMBL3640731 Ki 46.0 nM
COC(=O)c1cccc(COC[C@@H](C#N)NC(=O)[C@H](Cc2cccc(C)c2)NC(=O)C(c2ccccc2)c2ccccc2)c1 CHEMBL342463 IC50 47.0 nM
CCCCNC(=O)C(=O)[C@H](CC)NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1 CHEMBL3649392 IC50 47.8 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc([C@@H](O)C(F)F)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccccc1 CHEMBL1288527 IC50 48.0 nM
Cc1cccc(C[C@H](Nc2ccccc2)C(=O)N[C@H](C#N)COCc2cccc(C(=O)O)c2)c1 CHEMBL334717 IC50 49.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NCc1ccccc1 CHEMBL3359775 IC50 50.0 nM
CCOC(=O)/C=C/C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 CHEMBL4244656 IC50 50.0 nM
CCOC(=O)/C=C/C(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL4245127 IC50 50.0 nM
C[C@@H](OCc1ccccc1)[C@@H](C#N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(-c2ccccc2)cc1 CHEMBL4796183 pKi 50.12 nM
CCC[C@H](NC(=O)[C@@H]1[C@H]2CCC[C@H]2CN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1cnccn1)C(C)C)C(C)(C)C)C(=O)C(=O)N[C@@H](C)c1ccccc1 CHEMBL87150 Ki 52.0 nM
CC[C@@H](C)[C@H](NC(=O)c1ccccc1)C(=O)N[C@@H](C=O)Cc1c[nH]c2ccccc12 CHEMBL1790996 IC50 52.0 nM
CC(C)C(NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NC1CCCCC1 CHEMBL3359773 IC50 52.0 nM
CC(C)C(Nc1ccccc1)C(=O)N1CCCCN1C#N CHEMBL492617 IC50 53.0 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(-c3ccncc3)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccccc1 CHEMBL1288528 IC50 54.0 nM
C[C@H](NC(=O)OCc1ccccc1)C(=O)N(C)N(C)C#N CHEMBL1651241 Ki 55.0 nM
N#Cc1ccc(Nc2nc(C#N)nc(N3CCNCC3)n2)cc1 CHEMBL3927922 IC50 57.0 nM
Cc1cccc(CNc2nc(C#N)nc(N3CCNCC3)n2)c1 CHEMBL3936923 IC50 57.0 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@@H](C)C(=O)CNS(=O)(=O)c1ccccn1 CHEMBL31545 Ki 59.0 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2cn[nH]c2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccccc1 CHEMBL1289764 IC50 59.0 nM
CC(C)C[C@H](CCSc1ccc2ccccc2c1)C(=O)N[C@H](C=O)CC(C)C CHEMBL439590 IC50 60.0 nM
CC(C)C[C@H](CC[S+]([O-])c1ccc2ccccc2c1)C(=O)N[C@H](C=O)CC(C)C CHEMBL98832 IC50 60.0 nM
CCOC(=O)/C=C/C(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 CHEMBL4238441 IC50 60.0 nM
CCCN1CCN(c2ccc(C(=O)NC3(C(=O)NCC#N)CCCCC3)cc2)CC1 CHEMBL371064 IC50 61.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCC(C)C CHEMBL3649415 IC50 61.6 nM
CCN(CC)Cc1ccc(/C=C/c2ccccc2C(=O)NC(Cc2ccccc2)C(N)=O)cc1 CHEMBL80605 Ki 62.0 nM
CCCC(F)(F)C[C@H](NC(=O)N1CCC2(CC1)CC2)C(=O)NC1(C#N)CC1 CHEMBL3640728 Ki 62.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649369 IC50 62.7 nM
C[C@@H](OCc1ccccc1)[C@@H](C#N)NC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)c1cccc(Br)c1 CHEMBL4744431 pKi 63.1 nM
C[C@@H](OCc1ccccc1)[C@@H](C#N)NC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)c1cccc(-c2cncnc2)c1 CHEMBL4758783 pKi 63.1 nM
CC(C)C[C@H](NC(=O)N1CCOCC1)C(=O)N[C@H](/C=C/S(=O)(=O)c1ccccc1)CCc1ccccc1 CHEMBL486232 Ki 64.0 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(C3(C(=O)N4CCOCC4)CC3)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccccc1 CHEMBL1288526 IC50 64.0 nM
CC(C)C[C@H](NC(=O)C1OC1C(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN=[N+]=[N-] CHEMBL4443064 Ki 64.0 nM
COC(=O)C[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@@H](C=O)Cc1c[nH]c2ccccc12 CHEMBL132595 IC50 65.0 nM
CCC[C@H](NC(=O)C(CC(C)C)NC(=O)c1ccc(-c2ccc(I)cc2)cc1)C(=O)C=[N+]=[N-] CHEMBL518284 IC50 65.0 nM
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)CF)OCc1ccccc1 CHEMBL2368566 IC50 65.6 nM
CCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)N[C@H](C(=O)C(=O)NC1CCCCC1)C(C)C CHEMBL3359778 IC50 67.0 nM
CCCC[C@H](NC(=O)O[C@H](Cn1ccc(-c2ccc(C(F)(F)F)cc2)n1)C(C)(C)C)C(=O)CNc1cccc(F)n1 CHEMBL232911 IC50 68.0 nM
CS(=O)(=O)c1ccc(-c2ccc([C@H](N[C@H](C(=O)N[C@H](C#N)Cc3ccccc3)C3CC3)C(F)(F)F)cc2)cc1 CHEMBL1290303 IC50 68.0 nM
CC(C)C[C@@H](/C=C/[N+](=O)[O-])NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 CHEMBL3934979 Ki 68.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCCc1cccc2ccccc12 CHEMBL3649411 IC50 68.8 nM
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)OCc1ccccc1 CHEMBL36801 IC50 69.7 nM
Cc1ccc(S(=O)(=O)N[C@@H](CC(C)C)C(=O)NC(C=O)Cc2ccccc2)cc1 CHEMBL350182 Ki 70.0 nM
CCOC(=O)/C=C/C(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)N1CCOCC1 CHEMBL4242138 IC50 70.0 nM
CCOC(=O)/C=C/C(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL4248915 IC50 70.0 nM
CCOC(=O)/C=C/C(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 CHEMBL4251480 IC50 70.0 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(I)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649379 IC50 70.1 nM
C[C@H](NC(=O)O[C@H](Cn1cnc2cc(Cl)c(Cl)cc21)C(C)(C)C)C(=O)CNS(=O)(=O)c1ccccn1 CHEMBL232712 IC50 71.0 nM
CCCC[C@@H](C=O)NC(=O)O[C@@H](CC)Cc1ccccc1 CHEMBL114462 IC50 72.0 nM
Cc1cccc(C[C@H](NC(=O)c2ccc(Cl)cc2F)C(=O)NCC#N)c1 CHEMBL142118 IC50 72.0 nM
CCCC[C@H](NC(=O)O[C@H](Cn1cc(-c2ccc(C(F)(F)F)cc2)cn1)C(C)(C)C)C(=O)CNS(=O)(=O)c1ccccn1 CHEMBL393673 IC50 72.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](/C=C/[N+](=O)[O-])CCc1ccccc1 CHEMBL3930083 Ki 72.0 nM
CCC[C@H](NC(=O)C(NC(=O)c1ccc(OC(F)(F)F)cc1)C(=O)C1(N)CCCCC1)C(=O)c1nnc(-c2ccco2)o1 CHEMBL378899 Ki app 75.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCc1ccccc1 CHEMBL3649394 IC50 77.0 nM
CC(C)C[C@H](C=O)NC(=O)[C@@H](NS(=O)(=O)c1ccc(F)cc1)C(C)C CHEMBL168471 IC50 78.0 nM
CCCC[C@H](NC(=O)O[C@H](Cn1ccc(-c2cccnc2)n1)C(C)(C)C)C(=O)CNS(=O)(=O)c1ccccn1 CHEMBL232520 IC50 79.0 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccncc1 CHEMBL1289660 IC50 79.0 nM
N#Cc1nc(Nc2cccc([N+](=O)[O-])c2)nc(NC2CCCCC2)n1 CHEMBL3954506 IC50 79.0 nM
CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)OC)[C@@H](C)CC CHEMBL262103 IC50 80.0 nM
CCOC(=O)/C=C/C(=O)[C@@H](CCc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)N1CCOCC1 CHEMBL4247707 IC50 80.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NCC(=O)N1CCCCC1 CHEMBL3360289 IC50 81.0 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(N3CCNCC3)cc2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL195454 IC50 82.0 nM
CN(C)Cc1ccc(/C=C/c2ncccc2C(=O)NC(Cc2ccccc2)C(N)=O)cc1 CHEMBL80933 Ki 83.0 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(F)cc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649409 IC50 83.2 nM
CCCC(F)(F)C[C@H](NC(=O)N1CCC2(CC1)CCN(C1CC1)CC2)C(=O)NC1(C#N)CC1 CHEMBL3640726 Ki 84.0 nM
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)OCc1ccccc1 CHEMBL36146 IC50 85.1 nM
O=C[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 CHEMBL177914 IC50 85.1 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCCOC CHEMBL3649414 IC50 85.4 nM
CC(C)[C@H](N[C@@H](c1ccc(-c2ccc([C@@H](O)C(F)F)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccc(C#N)cc1F CHEMBL1288532 IC50 87.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NCC(=O)N1CCOCC1 CHEMBL3360290 IC50 88.0 nM
O=CC(Cc1ccccc1)NC(=O)[C@H]1CSCN1S(=O)(=O)c1ccc(Br)cc1 CHEMBL213081 Ki 90.0 nM
CC(C)C[C@H](NC(=O)C1CCNCC1)C(=O)N[C@@H](CCc1ccccc1)C(=O)c1nc2cc(S(N)(=O)=O)ccc2o1 CHEMBL446718 Ki 90.0 nM
CCOC(=O)/C=C/C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)N1CCOCC1 CHEMBL4237990 IC50 90.0 nM
CC(C)C[C@H](Nc1cccc(-c2ccc(N3CCNCC3)cc2)c1)C(=O)NCC#N CHEMBL185431 IC50 93.0 nM
CCC[C@H](NC(=O)C1(NC(=O)c2ccc(OC(F)(F)F)cc2)CCCCC1)C(=O)c1nnc(OC)o1 CHEMBL379622 Ki app 93.0 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(N3CCOCC3)cc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649417 IC50 93.2 nM
CC(C)[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649389 IC50 97.3 nM
COc1ccc(C[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)OCc2ccccc2)C(=O)O)cc1 CHEMBL36904 IC50 97.7 nM
CCC[C@H](NC(=O)C1(NC(=O)c2ccc(OC(F)(F)F)cc2)CCCCC1)C(=O)c1nnc(CC)o1 CHEMBL405602 Ki app 98.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Br)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649376 IC50 98.5 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1ccccc1/C=C/c1ccc2ccccc2c1 CHEMBL280587 Ki 99.0 nM
NC(=O)C(Cc1ccccc1)NC(=O)c1ccccc1/C=C/c1cccc2ccccc12 CHEMBL310855 Ki 99.0 nM
CN1CCC(C#N)(NC(=O)[C@H](CC(C)(F)F)NC(=O)N2CCC3(CC2)CC3)CC1 CHEMBL3640729 Ki 99.0 nM
CCC(C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@H](C=O)CC(C)C CHEMBL134494 IC50 100.0 nM
CC(C)C[C@H](NC(=O)c1cc2cc(OCCN3CCOCC3)ccc2o1)C(=O)N[C@H]1CCCN(C(=O)Cc2cccc(-c3ccccn3)c2)CC1=O CHEMBL284939 Ki 100.0 nM
CCNC(=O)C(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](NC(=O)CCCCC1CCSS1)C(C)C CHEMBL198962 IC50 100.0 nM
CC(F)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC(C#N)(C1CC1)C1CC1 CHEMBL399733 IC50 100.0 nM
N#CC1(NC(=O)[C@H](CC(F)(F)Cc2ccccc2)NC(=O)N2CCC3(CC2)CCN(C2CC2)CC3)CC1 CHEMBL3640727 Ki 100.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(N3CCOCC3)cc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649416 IC50 101.1 nM
O=C(N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCc1ccccc1)CNc1ccc(N2CCCCC2)cc1)OCc1ccccc1 CHEMBL169560 Ki 106.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(I)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649378 IC50 106.8 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCC CHEMBL3649405 IC50 107.6 nM
CC[C@@H](C)[C@H](NS(=O)(=O)c1ccc(C)cc1)C(=O)N[C@@H](C=O)Cc1c[nH]c2ccccc12 CHEMBL1790999 IC50 110.0 nM
Cc1cccc(C[C@H](NC(=O)c2ccc(F)cc2F)C(=O)N[C@H](C#N)CCCc2cccc(C(=O)O)c2)c1 CHEMBL342437 IC50 110.0 nM
O=CC(Cc1ccccc1)NC(=O)[C@H]1CSCN1S(=O)(=O)c1ccc(I)cc1 CHEMBL211477 Ki 110.0 nM
CC(C)C(Nc1ccc(Cl)cc1)C(=O)N1CCCCN1C#N CHEMBL523166 IC50 110.0 nM
N#CC1(NC(=O)[C@H](CC(F)(F)Cc2ccccc2)NC(=O)N2CCC3(CC2)CC3)CC1 CHEMBL3640716 Ki 110.0 nM
Cc1cc(O)cc(C)c1C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](CO)NC(=O)[C@@H](CO)NC(=O)[C@H](Cc1cn(CCNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)C2OC2C(=O)O)nn1)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C CHEMBL4588311 Ki 110.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)CSC(C)(C)C CHEMBL160000 Ki 111.8 nM
CCNC(=O)C(=O)[C@H](CC)NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1 CHEMBL3649404 IC50 112.3 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(Cl)cc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649403 IC50 115.4 nM
Cc1ccc(S(=O)(=O)N2CSC[C@@H]2C(=O)NC(C=O)Cc2ccccc2)cc1 CHEMBL211830 Ki 119.0 nM
CS(=O)(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL88646 Ki 120.0 nM
CCC(C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@H](C=O)C(C)C CHEMBL341197 IC50 120.0 nM
CCNC(=O)C(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](CC(C)C)NC(=O)CCCCC1CCSS1 CHEMBL199007 IC50 120.0 nM
CC(C)CC(C(=O)N[C@H](C=O)Cc1ccccc1)C(=O)OCc1ccccc1 CHEMBL378702 Ki 120.0 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1)C(=O)C(=O)NCc1ccccc1 CHEMBL3649422 IC50 120.0 nM
N#CCNC(=O)[C@H](Cc1cccc(Br)c1)NC(=O)c1ccc(-c2ccccc2)cc1 CHEMBL3805662 Ki 120.0 nM
N#CCNC(=O)[C@H](Cc1cccc(I)c1)NC(=O)C(c1ccccc1)c1ccccc1 CHEMBL139132 IC50 121.0 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccccc1 CHEMBL1289440 IC50 122.0 nM
CC(C)C[C@H](Nc1cscc1-c1ccc(N2CCNCC2)cc1)C(=O)NCC#N CHEMBL182956 IC50 123.0 nM
C[C@@H](OCc1ccccc1)[C@@H](C#N)NC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)c1cccc(-c2ccccc2)c1 CHEMBL4778004 pKi 125.89 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)OC)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL414145 IC50 126.0 nM
N#CCNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1ccc(-c2ccccc2)cc1 CHEMBL3805807 Ki 126.0 nM
N#CCNC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)C(c1ccccc1)c1ccccc1 CHEMBL343957 IC50 130.0 nM
CCCC[C@H](NC(=O)O[C@H](Cn1cnc(-c2ccc(C(F)(F)F)cc2)c1)C(C)(C)C)C(=O)CNS(=O)(=O)c1ccccn1 CHEMBL233706 IC50 130.0 nM
N#C[C@H](COCc1cn(CCC(=O)O)nn1)NC(=O)[C@H](Cc1cccc(Br)c1)NC(=O)c1ccc(-c2ccccc2)cc1 CHEMBL3805261 Ki 132.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)c1cnccn1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL409875 IC50 133.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)CSCCCc1ccccc1 CHEMBL162474 Ki 135.9 nM
CCc1cccc(C[C@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCC#N)c1 CHEMBL423923 IC50 136.0 nM
N#Cc1nc(NC[C@H](O)c2ccccc2)nc(N2CCNCC2)n1 CHEMBL3899928 IC50 136.0 nM
Cc1cccc(C[C@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C#N)CCOc2cccc(C(=O)O)c2)c1 CHEMBL140429 IC50 138.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(F)cc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649400 IC50 139.7 nM
CCN(CC)c1ccc2cc(C(=O)NC3(C(=O)N(C)N(C)C#N)CCCCC3)c(=O)oc2c1 CHEMBL2203962 Ki 140.0 nM
CCCC(F)(F)C[C@H](NC(=O)N1CCC2(CC1)CCN(c1ccc(OC)cc1)C2)C(=O)NC1(C#N)CC1 CHEMBL3640725 Ki 140.0 nM
CCOC(=O)/C=C/C(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)N1CCOCC1 CHEMBL4249696 IC50 140.0 nM
CCOC(=O)/C=C/C(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 CHEMBL4240920 IC50 140.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649374 IC50 142.2 nM
CC(C)[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccc(C#N)cc1F CHEMBL1288530 IC50 143.0 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649383 IC50 143.6 nM
O=C(NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCc1ccccc1)N/C=C/S(=O)(=O)c1ccc2ccccc2c1)NN1CCOCC1 CHEMBL3142836 Ki 150.0 nM
N#CN1CC(CNC(=O)C2CCCCC2)C1 CHEMBL8796 IC50 150.0 nM
CC(C)C[C@H](CCS(=O)(=O)c1ccc2ccccc2c1)C(=O)N[C@H](C=O)CC(C)C CHEMBL100316 IC50 150.0 nM
O=C(N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H]1CCCN(S(=O)(=O)c2ccccn2)CC1=O)c1cccc2ccccc12 CHEMBL194643 Ki app 150.0 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)c1cccc(O)c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL266566 IC50 150.0 nM
CCCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O CHEMBL304784 Ki 150.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Br)cc2F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649375 IC50 150.3 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(Cl)cc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649399 IC50 154.2 nM
CC(C)C[C@H](Nc1cscc1Br)C(=O)NCC#N CHEMBL365007 IC50 158.0 nM
O=C1O[C@H]2CN1CC[C@@H]2Br CHEMBL397972 IC50 158.0 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)OCc1ccncc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL394270 IC50 158.0 nM
C[C@@H](OCc1ccccc1)[C@@H](C#N)NC(=O)[C@H](Cc1cccc(Br)c1)NC(=O)c1cc(C(C)(C)C)nn1C CHEMBL4746022 pKi 158.49 nM
C[C@@H](OCc1ccccc1)[C@@H](C#N)NC(=O)[C@H](Cc1ccc(Br)cc1)NC(=O)c1ccc(-c2ccccc2)cc1 CHEMBL4765197 pKi 158.49 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccccc1 CHEMBL399361 IC50 163.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649382 IC50 165.0 nM
O=C(N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)CNc1ccc(N2CCCCC2)cc1)OCc1ccccc1 CHEMBL169448 Ki 167.0 nM
CCCC[C@H](NC(=O)O[C@H](Cn1ccc(-c2ccc(C(F)(F)F)cc2)n1)C(C)(C)C)C(=O)CNS(=O)(=O)c1ccccn1 CHEMBL203463 IC50 170.0 nM
CS(=O)(=O)C[C@H](N[C@@H](c1ccc(-c2ccc(F)cc2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL248889 IC50 170.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)OC)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL393733 IC50 171.0 nM
CCCCNC(=O)C(=O)[C@H](CCC)NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1 CHEMBL3649421 IC50 172.2 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCCc1ccc2ccccc2c1 CHEMBL3639482 IC50 172.4 nM
CC(C)C[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649390 IC50 178.2 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)c1nc2ccccc2o1 CHEMBL3649373 IC50 182.6 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)c1cccnc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL231862 IC50 186.0 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC(C)C CHEMBL3649402 IC50 187.1 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CCOCC1 CHEMBL3649413 IC50 188.4 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649385 IC50 189.6 nM
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCCN(S(=O)(=O)c2ccccn2)CC1=O)c1cc2ccccc2o1 CHEMBL407633 Ki app 193.0 nM
Cc1cccc(C[C@H](Nc2ccccc2)C(=O)N[C@H](C#N)COCc2ccccc2)c1 CHEMBL133508 IC50 194.0 nM
CN(C(=O)OC(C)(C)C)N(C#N)CC(=O)N1CCOCC1 CHEMBL3342186 Ki 194.0 nM
C[C@@H](OCc1ccccc1)[C@@H](C#N)NC(=O)[C@H](Cc1cccc(Cl)c1)NS(=O)(=O)c1ccc(-c2ccccc2)cc1 CHEMBL4780230 pKi 199.53 nM
N#CN1CCC(NC(=O)OCc2ccccc2)C1 CHEMBL273229 IC50 200.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCCc1ccccc1 CHEMBL119622 Ki 200.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCc1ccccn1 CHEMBL132839 Ki 200.0 nM
C[C@H]1C[C@@H](C(=O)N[C@H](CO)CCCNC(=N)N)N(C(=O)[C@@H](CCc2ccc(O)cc2)NC(=O)[C@H](O)Cc2ccc(O)cc2)C1 CHEMBL2147469 EC50 200.0 nM
O=C(CF)CNC(=O)[C@H](Cc1ccccc1)NC(=O)c1cccc2ccccc12 CHEMBL4520267 IC50(app) 200.0 nM
COc1cccc2[nH]c(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]3CCCNC3=O)C(=O)COC(=O)c3c(C)cc(C)nc3C)cc12 CHEMBL5191060 IC50 201.0 nM
CCCCS(=O)(=O)CC(NC(=O)OCCC#N)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL231864 IC50 205.0 nM
Cc1ccc(/C(=N/NC(N)=S)c2cccc(C(F)(F)F)c2)cc1 CHEMBL407264 IC50 210.0 nM
CCC[C@H](NC(=O)[C@@H]1[C@H]2CCC[C@H]2CN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1cnccn1)C1CCCCC1)C(C)(C)C)C(=O)C(=O)NC1CC1 CHEMBL231813 IC50 210.0 nM
O=C(NC1CC1)C(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1 CHEMBL3649391 IC50 210.0 nM
CC(C)C[C@@H](/C=C/[N+](=O)[O-])NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL3921142 Ki 210.0 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CC1)CCN(C1CC1)CC2)C(=O)NC1(C#N)CC1 CHEMBL3640714 Ki 210.0 nM
CC1=CC(C)=[N+]2C1=C(CCCc1cn(CCCCCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)COC(=O)c3c(C)cccc3C)C(C)C)nn1)c1c(C)cc(C)n1[B-]2(F)F CHEMBL4565998 Ki 210.0 nM
CC[C@@H](C)[C@H](NC(=O)Nc1ccccc1C(F)(F)F)C(=O)N[C@@H](C=O)Cc1c[nH]c2ccccc12 CHEMBL1790991 IC50 220.0 nM
CCC[C@H](NC(=O)C1(NC(=O)c2ccc(OC(F)(F)F)cc2)CCCCC1)C(=O)c1nnc(-c2ccco2)o1 CHEMBL209215 Ki app 220.0 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CCCCC2)C1)C(=O)NC1(C#N)CC1 CHEMBL3640719 Ki 220.0 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(O[C@@H](C)C(F)(F)F)cc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649407 IC50 223.8 nM
O=CC(Cc1ccccc1)NC(=O)[C@H]1CSCN1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL379594 Ki 230.0 nM
CS(=O)(=O)c1ccc(-c2ccc([C@H](N[C@@H](CC3CC3)C(=O)N[C@H](C#N)Cc3ccccc3)C(F)(F)F)cc2)cc1 CHEMBL1289988 IC50 231.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccncc1)C(C)(C)C)C(=O)C(=O)NC1CCCCC1 CHEMBL3359783 IC50 231.0 nM
COC1=CC(=O)N(C(=O)/C=C/[C@H](CCc2ccccc2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)N(C)C)[C@H]1Cc1c[nH]c2ccccc12 CHEMBL4596647 Ki(app) 238.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)NCc1ccc(CN(C)C)cc1 CHEMBL3360284 IC50 242.0 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649381 IC50 245.2 nM
CCCC(C)NC(=O)C(=O)[C@H](CCC)NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1 CHEMBL3649398 IC50 245.9 nM
N#CN1CC(CNC(=O)c2ccccc2)C1 CHEMBL8577 IC50 250.0 nM
Nc1cc(OC(=O)c2cccs2)nn1S(=O)(=O)c1ccccc1 CHEMBL389130 IC50 250.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649386 IC50 251.4 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@@H](C#N)Cc1ccc(C#N)cc1F CHEMBL1288524 IC50 260.0 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CC1)CC2)C(=O)NC1(C#N)CC1 CHEMBL3640715 Ki 260.0 nM
CC[C@@H](C)[C@H](NC(=O)NCc1ccccc1)C(=O)N[C@@H](C=O)Cc1c[nH]c2ccccc12 CHEMBL1790990 IC50 270.0 nM
CC[C@@H](C)[C@H](NC(=O)Nc1cccc(C)c1)C(=O)N[C@@H](C=O)Cc1c[nH]c2ccccc12 CHEMBL1790997 IC50 270.0 nM
CCC(C)[C@H](NC(=O)c1cccc(CN)c1)C(=O)N[C@@H](CCc1ccccc1)C(=O)CO CHEMBL98540 Ki 270.0 nM
CCCC[C@@H](/C=N/NC(=O)N1CCOCC1)NC(=O)O[C@@H](C)Cc1ccccc1 CHEMBL204605 IC50 270.0 nM
CCC[C@H](NC(=O)C1(NC(=O)c2ccc(OC(F)(F)F)cc2)CCCCC1)C(=O)c1nnc(-c2cccs2)o1 CHEMBL209114 Ki app 270.0 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)c1cccc(Cl)c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL266565 IC50 271.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)C1CC[N+](C)(C)CC1)C(C)(C)C)C(=O)C(=O)NCc1ccccc1 CHEMBL3359786 IC50 274.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCCCCO CHEMBL133106 Ki 280.0 nM
N#CCNC(=O)C1(NC(=O)c2ccc(-c3ccc(C4(F)CCNCC4)cc3)cc2)CCCCC1 CHEMBL200788 Ki app 280.0 nM
CS(=O)(=O)C[C@H](N[C@@H](c1ccc(Br)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL400387 IC50 280.0 nM
Cc1cccc(C[C@H](Nc2ccccc2)C(=O)N[C@H](C#N)COCc2ccc(C(=O)O)cc2)c1 CHEMBL133785 IC50 282.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)C1CCN(C)CC1)C(C)(C)C)C(=O)C(=O)NCc1ccccc1 CHEMBL3359785 IC50 283.0 nM
N#CC1(NC(=O)[C@H](CS(=O)(=O)CC2CC2)N[C@@H](c2ccccc2)C(F)(F)F)CC1 CHEMBL249712 IC50 287.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(OCC(F)(F)F)cc2C(F)(F)F)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649372 IC50 291.1 nM
N#CN1CC(CNS(=O)(=O)c2ccccc2)C1 CHEMBL276169 IC50 300.0 nM
N#CN1CCC(NC(=O)c2ccc(-c3ccccc3)cc2)C1 CHEMBL8816 IC50 300.0 nM
COC(=O)CC(NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)CF CHEMBL23453 IC50 300.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCc1nccc2ccccc12 CHEMBL422260 Ki 300.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NCCc1ccccc1 CHEMBL416281 Ki 300.0 nM
NC(=S)N/N=C(/c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cccs1 CHEMBL260921 IC50 300.0 nM
NC(=S)N/N=C(/c1cc(Cl)cc(Cl)c1)c1cccs1 CHEMBL259379 IC50 300.0 nM
CN1CCN(C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](/C=C/S(=O)(=O)c2ccccc2)c2ccc(-c3ccccc3)cc2)CC1 CHEMBL4590300 IC50 300.0 nM
C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)CF CHEMBL2402203 IC50(app) 300.0 nM
Cc1cccc(C[C@H](NC(=O)c2ccc(Cl)cc2)C(=O)NCC#N)c1 CHEMBL436604 IC50 308.0 nM
CC[C@@H](C)[C@H](/N=C(\S)Nc1cccc2ccccc12)C(=O)N[C@@H](C=O)Cc1c[nH]c2ccccc12 CHEMBL1790994 IC50 310.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCc1cccc(OC)c1 CHEMBL130338 Ki 310.0 nM
C[C@@H](CC1CCCCC1)OC(=O)C1CCCN1C#N CHEMBL180839 IC50 310.0 nM
C[C@H](NC(=O)O[C@H](Cn1ccc(-c2ccc(C(F)(F)F)cc2)n1)C(C)(C)C)C(=O)CNS(=O)(=O)c1ccccn1 CHEMBL540964 IC50 310.0 nM
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H](/C=C/[N+](=O)[O-])Cc1ccccc1)OCc1ccccc1 CHEMBL3903171 Ki 310.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)/C=C/[N+](=O)[O-] CHEMBL3982135 Ki 310.0 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CC1)CC(=O)N(CC1CC1)C2)C(=O)NC1(C#N)CC1 CHEMBL3640724 Ki 310.0 nM
CC(C)C(NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NC1CCOCC1 CHEMBL3359787 IC50 311.0 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL1289441 IC50 312.0 nM
N#CCNC(=O)[C@@H]1CCCC[C@H]1C(=O)N1CCN(c2ccc(F)cc2)CC1 CHEMBL2171984 IC50 315.0 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)c1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL234555 IC50 316.0 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)c1ccc(OC)cc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL231861 IC50 320.0 nM
CC(C)[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649418 IC50 323.4 nM
CSCC[C@@H](C#N)NC(=O)[C@H](CC(C)C)NC(=O)c1ccc(-c2ccccc2)cc1 CHEMBL3805185 Ki 330.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(O[C@@H](C)C(F)(F)F)cc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649406 IC50 335.2 nM
CC(C)CS(=O)(=O)C[C@H](N[C@@H](c1ccc(F)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL399063 IC50 337.0 nM
O=C(NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@H](CCc1ccccc1)N/C=C/S(=O)(=O)c1ccccc1)NN1CCOCC1 CHEMBL3142837 Ki 340.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCc1ccc2ccccc2n1 CHEMBL134283 Ki 340.0 nM
CN1CCC(N(C)c2ccc(-c3ccc(C(=O)NC4(C(=O)NCC#N)CCCCC4)cc3)cc2)C1 CHEMBL381190 Ki app 340.0 nM
O=CC(Cc1ccccc1)NC(=O)[C@H]1CSCN1S(=O)(=O)c1ccc(F)cc1 CHEMBL378691 Ki 340.0 nM
O=C(N[C@H](/C=C/S(=O)(=O)c1ccccc1)CCc1ccccc1)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)N1CCOCC1 CHEMBL4474444 Ki 340.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)c1cc(C)[nH]n1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL409947 IC50 341.0 nM
COC1=CC(=O)N(C(=O)/C=C/[C@H](C)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@H](C(C)C)N(C)C)[C@H]1Cc1c[nH]c2ccccc12 CHEMBL4598338 Ki(app) 347.0 nM
CCCC(C)NC(=O)C(=O)[C@H](CC)NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1 CHEMBL3649397 IC50 349.5 nM
CCNC(=O)C(=O)C(CC)NC(=O)C(CC(C)C)NC(=O)Cc1cccc2ccccc12 CHEMBL130215 Ki 350.0 nM
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H]1C(=O)N2CCS(=O)(=O)[C@@H]12)OCc1ccccc1 CHEMBL326093 IC50 350.0 nM
CCCCNC(=O)C(=O)[C@H](CC)NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1 CHEMBL3649420 IC50 354.1 nM
Cc1cc(CN)cc(C[C@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCC#N)c1 CHEMBL138611 IC50 358.0 nM
CCCCS(=O)(=O)C[C@@H](NC(C)=O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL232490 IC50 360.0 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCC(F)(F)F CHEMBL3649401 IC50 366.2 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)NCc1cn[nH]c1 CHEMBL3360287 IC50 367.0 nM
N#C[C@H](Cc1cn(CC(=O)O)nn1)NC(=O)[C@H](Cc1cccc(Br)c1)NC(=O)c1ccc(-c2ccccc2)cc1 CHEMBL3805560 Ki 368.0 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)OCc1cccnc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL414776 IC50 369.0 nM
CC[C@@H](C)[C@H](NC(=O)Nc1cccc2ccccc12)C(=O)N[C@@H](C=O)Cc1c[nH]c2ccccc12 CHEMBL1790989 IC50 370.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC(O)c1ccccc1 CHEMBL130506 Ki 370.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)NC1CCCCC1 CHEMBL3359776 IC50 378.0 nM
CC(C)CC(C(=O)NCC#N)c1cccc(-c2ccc(N3CCN(C(C)(C)C)CC3)cc2)c1 CHEMBL123199 IC50 379.0 nM
N#CCNC(=O)C1(NC(=O)c2ccc(-c3ccc(S(=O)(=O)N4CCNCC4)cc3)cc2)CCCCC1 CHEMBL370165 Ki app 380.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)OCc1ccncc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL409950 IC50 383.0 nM
CS(=O)(=O)c1ccc(-c2ccc([C@H](N[C@@H](CC(Cl)Cl)C(=O)N[C@H](C#N)Cc3ccccc3)C(F)(F)F)cc2)cc1 CHEMBL1290084 IC50 383.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCc1cccc2ccccc12 CHEMBL3649412 IC50 385.5 nM
O=C(N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H]1C(=O)N2CCS(=O)(=O)[C@@H]12)OCc1ccccc1 CHEMBL323638 IC50 390.0 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)c1ccc(C)cc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL412852 IC50 396.0 nM
CC(=O)c1c(Nc2ccc(C)cc2Cl)[nH]c2c([N+](=O)[O-])cc(Cl)cc2c1=O CHEMBL521771 IC50 396.8 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)CCc1ccccc1 CHEMBL1288521 IC50 397.0 nM
COc1ccc(N2CCN(C(=O)[C@@H]3CCCC[C@H]3C(=O)NCC#N)CC2)cc1 CHEMBL2171986 IC50 399.0 nM
C[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649395 IC50 399.4 nM
CCCC[C@@H](C=O)NC(=O)O[C@@H](C)CC1CCCCC1 CHEMBL116402 IC50 400.0 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)c1ccccc1C)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL393140 IC50 404.0 nM
CC[C@@H](C)[C@H](/N=C(\S)NCc1ccccc1)C(=O)N[C@@H](C=O)Cc1c[nH]c2ccccc12 CHEMBL1790995 IC50 410.0 nM
CSC[C@H](N[C@@H](c1ccc(Br)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL249698 IC50 417.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)NC1CC1 CHEMBL3359789 IC50 417.0 nM
N#CCNC(=O)C1(NC(=O)c2ccc(-c3ccc(N4CCNCC4)cc3)cc2)CCCCC1 CHEMBL371133 Ki app 420.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649380 IC50 424.3 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N1Cc2ccccc2C1=O)C(C)(C)C)C(=O)C(=O)NCc1ccccc1 CHEMBL3359782 IC50 429.0 nM
O=C(N[C@@H](CC1CCCCC1)C(=O)N[C@@H]1C(=O)N2CCS(=O)(=O)[C@@H]12)OCc1ccccc1 CHEMBL114410 IC50 430.0 nM
O=C(N[C@@H](Cc1cccs1)C(=O)N[C@@H]1C(=O)N2CCS(=O)(=O)[C@@H]12)OCc1ccccc1 CHEMBL113706 IC50 430.0 nM
CCC[C@H](NC(=O)C1(NC(=O)c2ccc(OC(F)(F)F)cc2)CCCCC1)C(=O)c1nnc(C(C)C)o1 CHEMBL210535 Ki app 430.0 nM
CC(C)[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccccc1 CHEMBL1290191 IC50 433.0 nM
CS(=O)(=O)c1ccc(-c2ccc([C@H](N[C@@H](CC(F)(F)F)C(=O)NC(C#N)(C3CC3)C3CC3)C(F)(F)F)cc2)cc1 CHEMBL252784 IC50 434.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)SC1CCOC1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL409948 IC50 436.0 nM
CC[C@@H](C)[C@H](/N=C(\S)Nc1ccccc1)C(=O)N[C@@H](C=O)Cc1c[nH]c2ccccc12 CHEMBL1791000 IC50 440.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC1CCN(C(=O)[C@H](CC(C)C)NC(=O)OCc2ccccc2)CC1=O CHEMBL118449 Ki app 440.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCc1ccc(OC)cc1 CHEMBL134173 Ki 440.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC(NC(=O)[C@@H](CC(C)C)NC(=O)OCc2ccccc2)C(=O)C1 CHEMBL281086 Ki 440.0 nM
Nc1cc(OC(=O)c2cccs2)nn1S(=O)(=O)c1ccc(F)cc1 CHEMBL390485 IC50 440.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCCCn1ccc(N)nc1=O CHEMBL1240875 Ki 440.0 nM
O=C(N[C@H](C(=O)N1C[C@H](Cl)[C@H]2OCC(=O)[C@H]21)C1CCCCC1)c1cccc(-n2ccnc2)c1 CHEMBL3648411 Ki 440.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)OCc1cccnc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL409949 IC50 444.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)C1CC1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL231669 IC50 446.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)c1ccccc1)C(=O)C(=O)NCc1ccccc1 CHEMBL3359777 IC50 446.0 nM
N#CCNC(=O)[C@@H]1CCCC[C@H]1C(=O)N1CCN(c2ccccc2)CC1 CHEMBL2164676 IC50 455.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL3360285 IC50 459.0 nM
CC[C@@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](C=O)Cc1c[nH]c2ccccc12 CHEMBL1791001 IC50 460.0 nM
CCCC[C@@H](C=O)NC(=O)O[C@@H](C)Cc1ccccc1 CHEMBL114161 IC50 460.0 nM
C[C@@H]1CN(c2ccccc2)CCN1C(=O)[C@@H]1CCCC[C@H]1C(=O)NCC#N CHEMBL2172006 IC50 462.0 nM
COc1cccc2[nH]c(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]3CCCNC3=O)C(=O)COC(=O)c3c(C(F)(F)F)cccc3C(F)(F)F)cc12 CHEMBL5191092 IC50 464.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)c1cccnc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL266567 IC50 474.0 nM
CCC(C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@@H](C)C=O CHEMBL334443 IC50 480.0 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(-c3ccncc3)cc2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL377285 IC50 483.0 nM
CNC(=O)C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(C)C CHEMBL3359791 IC50 494.0 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)c1ccccc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL234762 IC50 495.0 nM
N#CCNC(=O)[C@H](Cc1ccccc1)NC(=O)C(c1ccccc1)c1ccccc1 CHEMBL342145 IC50 496.0 nM
N#CN1CC(OCc2ccccc2)C1 CHEMBL8547 IC50 500.0 nM
N#CN1CC(OCC2CCCCC2)C1 CHEMBL8726 IC50 500.0 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@H]1CCCN(S(=O)(=O)c2ccccn2)CC1=O CHEMBL286364 Ki 500.0 nM
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)OCc1ccccc1)C(=O)N[C@H](/C=N/NC(N)=O)Cc1ccccc1 CHEMBL1950263 Ki 500.0 nM
C[C@@H](OCc1ccccc1)[C@@H](C#N)NC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)c1cc(C(C)(C)C)nn1C CHEMBL4751229 pKi 501.19 nM
CC(C)(C)N1CCN(c2ccc(-c3ccc(C(=O)NC4(C(=O)NCC#N)CCCCC4)cc3)cc2)CC1 CHEMBL200672 Ki app 510.0 nM
CC(C)C[C@@H](C(=O)N(C)N(C)C#N)N(C)C(=O)c1ccc(-c2noc(-c3cccs3)n2)cc1 CHEMBL1651362 Ki 510.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)NCC(=O)N1CCc2ccccc2C1 CHEMBL3360294 IC50 511.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)NCc1ccccc1 CHEMBL3360281 IC50 512.0 nM
CC(C)C[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649419 IC50 518.5 nM
S=C1O[C@@H]2CN1CC[C@@H]2Oc1ccccc1 CHEMBL390643 IC50 519.0 nM
N#Cc1nc(NC2CCCCC2)nc(N2CCNCC2)n1 CHEMBL1084679 IC50 520.0 nM
C[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@@H](C=O)Cc1c[nH]c2ccccc12 CHEMBL342189 IC50 530.0 nM
CC[C@@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C=O)Cc1c[nH]c2ccccc12 CHEMBL1790998 IC50 530.0 nM
CN1CCC(Oc2ccc(-c3ccc(C(=O)NC4(C(=O)NCC#N)CCCCC4)cc3)cc2)CC1 CHEMBL200426 Ki app 530.0 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CC1)OCc1ccccc12)C(=O)NC1(C#N)CC1 CHEMBL3640720 Ki 530.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1cccc2ccccc12)C(C)(C)C)C(=O)C(=O)NCc1ccc(S(N)(=O)=O)cc1 CHEMBL3360302 IC50 532.0 nM
COCCN1CCC(Oc2ccc(-c3ccc(C(=O)NC4(C(=O)NCC#N)CCCCC4)cc3)cc2)CC1 CHEMBL199214 Ki app 540.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cccc2ccccc12)C(=O)C(=O)NCC(=O)N1CCN(C)CC1 CHEMBL3360296 IC50 540.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NCC(=O)N1CCN(C)CC1 CHEMBL3360288 IC50 544.0 nM
CC(=O)CN1CCN(c2ccc(-c3cccc(C(CC(C)C)C(=O)NCC#N)c3)cc2)CC1 CHEMBL123200 IC50 550.0 nM
CC(C)CC(C(=O)NCC#N)c1cccc(-c2ccc(C3=CCNCC3)cc2)c1 CHEMBL123037 IC50 554.0 nM
N=C(N)NCCC[C@H](NC(=O)[C@H](CS)NC(=O)Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 CHEMBL3143405 Ki 560.0 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CC1)OCCO2)C(=O)NC1(C#N)CC1 CHEMBL3640709 Ki 560.0 nM
Cc1ccc(N2CCN(C(=O)[C@@H]3CCCC[C@H]3C(=O)NCC#N)CC2)cc1 CHEMBL2171985 IC50 572.0 nM
CS(=O)(=O)c1ccc(-c2ccc([C@H](N[C@@H](Cc3ccccc3)C(=O)N[C@H](C#N)Cc3ccccc3)C(F)(F)F)cc2)cc1 CHEMBL1288529 IC50 577.0 nM
CC[C@@H](C)[C@H](NC(=O)NC(C)C)C(=O)N[C@@H](C=O)Cc1c[nH]c2ccccc12 CHEMBL1790992 IC50 580.0 nM
CN1CCC[C@H]1COc1ccc(-c2ccc(C(=O)NC3(C(=O)NCC#N)CCCCC3)cc2)cc1 CHEMBL198802 Ki app 590.0 nM
Cc1cccc(C[C@H](NC(=O)c2ccc(F)cc2F)C(=O)NCC#N)c1 CHEMBL140824 IC50 591.0 nM
CC(C)(C)SCC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1cccnc1 CHEMBL161038 Ki 600.0 nM
Cc1noc2cc(N3CCN(C(=O)[C@@H]4CCCC[C@H]4C(=O)NC4(C#N)CC4)[C@H](C)C3)ccc12 CHEMBL2169908 IC50 603.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)c1ncc[nH]1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL391144 IC50 606.0 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CCCc3ccccc32)C1)C(=O)NC1(C#N)CC1 CHEMBL3640721 Ki 620.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccnc2ccccc12)C(C)(C)C)C(=O)C(=O)NC1CCCCC1 CHEMBL3359780 IC50 628.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCc1ccccc1OC CHEMBL130756 Ki 630.0 nM
CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)COC(=O)c3c(C)cccc3C)n1[B-]2(F)F CHEMBL3814336 Ki 630.0 nM
N#CCNC(=O)C1(NC(=O)c2ccc(-c3ccc(OC4CCN(CCO)CC4)cc3)cc2)CCCCC1 CHEMBL372410 Ki app 640.0 nM
C[C@@H]1CN(c2ccc3c(c2)OCO3)CCN1C(=O)[C@@H]1CCCC[C@H]1C(=O)NC1(C#N)CC1 CHEMBL2172004 IC50 645.0 nM
C[C@@H]1CN(c2ccccc2)CCN1C(=O)[C@@H]1CCCC[C@H]1C(=O)NC1(C#N)CC1 CHEMBL2172007 IC50 649.0 nM
CCNC(=O)C(=O)C(Cc1ccc(Br)cc1)NC(=O)[C@H](CC(C)C)NC(=O)CCCCC1CCSS1 CHEMBL200826 IC50 650.0 nM
O=C(N[C@H](C(=O)N1C[C@H](Cl)[C@H]2OCC(=O)[C@H]21)C1CCCCC1)c1cccc(-n2cnnn2)c1 CHEMBL3648405 Ki 650.0 nM
Cc1cncc(C[C@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCC#N)c1 CHEMBL345081 IC50 652.0 nM
CC(C)C[C@@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)CNc1ccc(N2CCCCC2)cc1 CHEMBL354439 Ki 658.0 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)CC(F)(F)F CHEMBL1289553 IC50 668.0 nM
N#CCNC(=O)C1(NC(=O)c2ccc(-c3csc(N4CCC(N5CCOCC5)CC4)n3)cc2)CCCCC1 CHEMBL200494 Ki app 670.0 nM
C[C@@H](CC1CCCCC1)OC(=O)N[C@H]1CCN(C#N)C1 CHEMBL183660 IC50 680.0 nM
CN(C)c1ccc(-c2ccc(C(=O)NC3(C(=O)NCC#N)CCCCC3)cc2)cc1 CHEMBL383186 Ki app 680.0 nM
N#CCNC(=O)C1(NC(=O)c2ccc(-c3csc(N4CCC(N5CCCCC5)CC4)n3)cc2)CCCCC1 CHEMBL198798 Ki app 690.0 nM
COc1ccc(S(=O)(=O)n2nc(OC(=O)c3cccs3)cc2N)cc1 CHEMBL243314 IC50 690.0 nM
O=C(N[C@@H](Cc1ccccc1)C(=O)NC1CC(=O)N(CCCc2ccccc2)CC1=O)OCc1ccccc1 CHEMBL316864 Ki 693.0 nM
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)C(=O)CSCCCc1ccccc1)OCc1cccnc1 CHEMBL347459 Ki 700.0 nM
C[C@H]1C[C@@H](C(=O)N(C)[C@H](CCCCN)C(=O)O)N(C(=O)[C@@H](CCc2ccc(O)cc2)NC(=O)[C@H](O)Cc2ccc(O)cc2)C1 CHEMBL2147467 EC50 700.0 nM
CC1CCN(C(=O)[C@@H]2C[C@H](S(=O)(=O)c3ccccc3)C[C@H]2C(=O)NC2(C#N)CC2)CC1 CHEMBL3093826 IC50 700.0 nM
O=C(CF)CNC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1 CHEMBL4590201 IC50(app) 700.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](/C=C/[N+](=O)[O-])Cc1ccccc1 CHEMBL3893138 Ki 710.0 nM
N#CCNC(=O)[C@@H]1CCCC[C@H]1C(=O)N1CCc2ccccc2C1 CHEMBL2164674 IC50 712.0 nM
CN(C)c1ccc(C[C@H](NC(=O)c2ccc(-c3ccccc3)cc2)C(=O)NC2(C#N)CC2)cc1 CHEMBL4228800 IC50 715.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1cccc2ccccc12)C(C)(C)C)C(=O)C(=O)NC1CCCCC1 CHEMBL3359779 IC50 721.0 nM
CCC[C@H](NC(=O)C1(NC(=O)c2ccc(N(C)C)cc2)CCCCC1)C(=O)c1nnc(-c2ccco2)o1 CHEMBL209293 Ki app 730.0 nM
CC(C)C[C@H](NC(=O)c1ccc2ccccc2n1)C(=O)N[C@H]1CCCN(S(=O)(=O)c2ccccn2)CC1=O CHEMBL433985 Ki app 740.0 nM
N#CCNC(=O)C1(NC(=O)c2ccc(-c3csc(OC4CCNCC4)n3)cc2)CCCCC1 CHEMBL200744 Ki app 740.0 nM
CCCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCc1ccccn1 CHEMBL132586 Ki 750.0 nM
CCC(NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCCn1ccc(N)nc1=O CHEMBL1242986 Ki 750.0 nM
CC(C)NC1CCN(c2nc(-c3ccc(C(=O)NC4(C(=O)NCC#N)CCCCC4)cc3)cs2)CC1 CHEMBL200287 Ki app 760.0 nM
O=C(NCc1ccccc1C(=O)N[C@H](/C=C/S(=O)(=O)Oc1ccccc1)CCc1ccccc1)c1cc(F)cc(F)c1 CHEMBL5182340 Ki 760.0 nM
Cc1nn(C)c2cc(N3CCN(C(=O)[C@@H]4CCCC[C@H]4C(=O)NC4(C#N)CC4)[C@H](C)C3)ccc12 CHEMBL2172000 IC50 766.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)c1cnccc1O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL266531 IC50 770.0 nM
O=C[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCC1 CHEMBL335942 IC50 780.0 nM
O=C(N[C@H](C(=O)N1C[C@H](Cl)[C@H]2OCC(=O)[C@H]21)C1CCCCC1)c1ccccc1 CHEMBL3648398 Ki 780.0 nM
CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@H](C(=O)NCCc1ccc(O)cc1)C(C)CC CHEMBL1242843 IC50 780.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCc1ccccn1 CHEMBL129933 Ki 800.0 nM
CCC(NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCCn1cnc2c(N)ncnc21 CHEMBL1242960 Ki 800.0 nM
N#Cc1nc(Nc2ccc(OC(F)(F)F)cc2)nc(NC2CCNCC2)n1 CHEMBL4243256 IC50 800.0 nM
O=C(NCc1ccccc1C(=O)N[C@H](/C=C/S(=O)(=O)Oc1ccccc1)CCc1ccccc1)c1ccc2c(c1)OCCO2 CHEMBL5208143 Ki 800.0 nM
[2H]C([2H])(OC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)C[C@@H]1CCNC1=O)C(C)(C)Oc1ccc(Cl)cc1 CHEMBL5402510 IC50 800.0 nM
CCCC[C@@H](C=O)NC(=O)OC1(Cc2ccccc2)CCCC1 CHEMBL117658 IC50 810.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(OCC(F)(F)F)cc2Cl)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649371 IC50 828.8 nM
N#C[C@H](COCc1cccc(C(=O)O)c1)NC(=O)[C@H](Cc1ccccc1)Nc1ccccc1 CHEMBL335269 IC50 832.0 nM
CCCCOc1ccc(C[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)OCc2ccccc2)C(=O)O)cc1 CHEMBL36969 IC50 836.0 nM
N#CCNC(=O)C1(NC(=O)c2ccc(-c3csc(N4CCN(C5CCOCC5)CC4)n3)cc2)CCCCC1 CHEMBL200543 Ki app 840.0 nM
CN(C#N)N(C)C(=O)CNC(=O)OCc1ccccc1 CHEMBL1651240 Ki 840.0 nM
CC(=O)N[C@@H](CCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](/C=C/S(C)(=O)=O)CC(C)C CHEMBL379669 IC50 850.0 nM
CN(C)C(=O)/C=C/CNC(=O)CN1C(=O)[C@@H](COC(=O)Nc2ccc(Cl)cc2C(F)(F)F)N=C(c2ccccc2)c2ccccc21 CHEMBL450218 Ki 850.0 nM
COC1=CC(=O)N(C(=O)/C=C/[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)C2CCN(C)CC2)[C@H]1Cc1c[nH]c2ccccc12 CHEMBL4594757 Ki(app) 854.0 nM
COC(=O)Cn1cc(COC[C@@H](C#N)NC(=O)[C@H](Cc2cccc(C)c2)NC(=O)c2ccc(F)cc2)nn1 CHEMBL5395533 Ki 860.0 nM
COC1=CC(=O)N(C(=O)/C=C/[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC2CCCCC2)NC(=O)C2CCN(C)CC2)[C@H]1Cc1c[nH]c2ccccc12 CHEMBL4594870 Ki(app) 861.0 nM
CN1CCCC(Oc2ccc(-c3ccc(C(=O)NC4(C(=O)NCC#N)CCCCC4)cc3)cc2)C1 CHEMBL435913 Ki app 870.0 nM
O=C[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)CCc2ccccc2)CCCC1 CHEMBL470973 Ki 880.0 nM
CCC(NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCCn1cnc2c(N)nc(OC)nc21 CHEMBL1240873 Ki 880.0 nM
CS(=O)(=O)N1CCC[C@H]1C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL310648 IC50 883.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC1(C)CC(O)CC(C)(C)C1 CHEMBL131781 Ki 890.0 nM
CN1CCN(N(C)c2nc(-c3ccc(C(=O)NC4(C(=O)NCC#N)CCCCC4)cc3)cs2)CC1 CHEMBL414669 Ki app 890.0 nM
CC(C)C[C@H](NC(=O)OCC(C)(C)Oc1cccc(Cl)c1)C(=O)N[C@H](C=O)C[C@@H]1CCNC1=O CHEMBL5414071 IC50 900.0 nM
CC(C)CC(NC(=O)c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(=O)N(C)N(C)C#N CHEMBL4541720 Ki 909.0 nM
CC(C)(C)N1CCN(c2nc(-c3ccc(C(=O)NC4(C(=O)NCC#N)CCCCC4)cc3)cs2)CC1 CHEMBL200708 Ki app 910.0 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CC1)CCC(C)(C)O2)C(=O)NC1(C#N)CC1 CHEMBL3640718 Ki 930.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)OCCNC(C)=O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL391145 IC50 935.0 nM
N#CCNC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccccc1 CHEMBL200884 IC50 940.0 nM
CCC[C@H](NC(=O)C1(NC(=O)c2ccc(F)cc2)CCCCC1)C(=O)c1nnc(-c2ccco2)o1 CHEMBL379157 Ki app 950.0 nM
Cc1nn(C)c2ccc(N3CCN(C(=O)[C@@H]4CCCC[C@H]4C(=O)NC4(C#N)CC4)[C@H](C)C3)cc12 CHEMBL2171999 IC50 971.0 nM
C[C@@H]1CN(c2ccc(S(C)(=O)=O)cc2)CCN1C(=O)[C@@H]1CCCC[C@H]1C(=O)NC1(C#N)CC1 CHEMBL2171995 IC50 977.0 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)NCc1ccc(S(N)(=O)=O)cc1 CHEMBL3360282 IC50 984.0 nM
CC(C)CN(NC(=O)c1ccc(CN2CCN(C)CC2)cc1)c1nc(C#N)ncc1Br CHEMBL1215628 IC50 987.0 nM