CCN(C#N)NC(=O)O[C@@H](C)CC1CCCCC1 CHEMBL190544 Ki 0.003 nM
CC(C)(C)CNc1nc(C#N)ncc1C(=O)NCCc1cccc(OCCn2ccnc2)c1 CHEMBL384685 IC50 0.003 nM
CC(C)(C)CNc1nc(C#N)ncc1C(=O)NCCc1ccc(OCCn2ccnc2)cc1 CHEMBL218007 IC50 0.003 nM
CCCN(C#N)NC(=O)O[C@@H](C)CC1CCCCC1 CHEMBL193095 Ki 0.004 nM
CC(C)CN(C#N)NC(=O)O[C@@H](C)CC1CCCCC1 CHEMBL192995 Ki 0.004 nM
CC(C)C[C@H](NC(=O)c1cc2cc(OCCN3CCOCC3)ccc2o1)C(=O)N[C@H]1CCCN(C(=O)Cc2cccc(-c3ccccn3)c2)CC1=O CHEMBL284939 Ki 0.0048 nM
C[C@@H](CC1CCCCC1)OC(=O)NN(C#N)Cc1ccccc1 CHEMBL433967 Ki 0.006 nM
CCCCN(C#N)NC(=O)O[C@@H](C)CC1CCCCC1 CHEMBL190063 Ki 0.007 nM
C[C@@H](CC1CCCCC1)OC(=O)NN(C)C#N CHEMBL190121 Ki 0.009 nM
COc1cccc(CCNC(=O)c2cnc(C#N)nc2NC2CCCCC2)c1 CHEMBL385632 IC50 0.009 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@@H]1C(=O)CN(S(=O)(=O)c2ccccn2)CC[C@@H]1C CHEMBL202668 Ki app 0.0099 nM
N#Cc1ncc(C(=O)NCCc2ccccc2)c(NC2CCCCC2)n1 CHEMBL386506 IC50 0.01 nM
CN1CCN(Cc2ccc(CCNC(=O)c3cnc(C#N)nc3NCC(C)(C)C)cc2)CC1 CHEMBL374890 IC50 0.011 nM
CN1CCN(c2cccc(CCNC(=O)c3cnc(C#N)nc3NCC(C)(C)C)c2)CC1 CHEMBL414530 IC50 0.011 nM
CC(C)C[C@H](NC(=O)NCc1ccccc1)C(=O)N(C)N(C)C#N CHEMBL1651354 Ki 0.011 nM
CN1CCC(Oc2ccc(CCNC(=O)c3cnc(C#N)nc3NCC(C)(C)C)cc2)CC1 CHEMBL449096 IC50 0.013 nM
CC(C)C[C@H](NC(=O)c1ccc(-c2ccc(N3CCNCC3)cc2)cc1)C(=O)NCC#N CHEMBL480317 IC50 0.015 nM
CC(C)C[C@H](NC(=O)Nc1ccccc1)C(=O)N(C)N(C)C#N CHEMBL1651355 Ki 0.017 nM
CC(C)N(C#N)NC(=O)O[C@@H](C)CC1CCCCC1 CHEMBL371420 Ki 0.019 nM
COc1ccc(CCNC(=O)c2cnc(C#N)nc2NC2CCCCC2)cc1 CHEMBL218024 IC50 0.022 nM
CC(C)C[C@H](NC(=O)Nc1ccc(-c2noc(-c3cccs3)n2)cc1)C(=O)N(C)N(C)C#N CHEMBL1651350 Ki 0.022 nM
CN1CCN(c2ccc(CCNC(=O)c3cnc(C#N)nc3NCC(C)(C)C)cc2)CC1 CHEMBL220760 IC50 0.025 nM
CCCC[C@H](NC(=O)O[C@H](Cn1cnc(-c2ccc(C(F)(F)F)cc2)c1)C(C)(C)C)C(=O)C(=O)Nc1ccn[nH]1 CHEMBL191584 pIC50 0.02512 nM
CCCC[C@H](NC(=O)O[C@H](Cn1cc(-c2ccc(C(F)(F)F)cc2)cn1)C(C)(C)C)C(=O)C(=O)Nc1ccn[nH]1 CHEMBL190053 pIC50 0.0257 nM
CCCC[C@H](NC(=O)O[C@H](Cc1nnc(-c2ccc(C(F)(F)F)cc2)o1)C(C)(C)C)C(=O)C(=O)Nc1ccn[nH]1 CHEMBL188400 pIC50 0.02884 nM
COc1ccc(CCNC(=O)c2cnc(C#N)nc2NCC(C)(C)C)cc1OCCn1ccnc1 CHEMBL436303 IC50 0.031 nM
CC[C@@H](Cc1ccccc1)OC(=O)NN(C)C#N CHEMBL191558 Ki 0.032 nM
CC(C)C[C@H](NC(=O)c1ccc(-c2noc(-c3cccs3)n2)cc1)C(=O)N(C)N(C)C#N CHEMBL1651361 Ki 0.032 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@H]1CC[C@@H](C)N(S(=O)(=O)c2ccccn2)CC1=O CHEMBL203665 Ki app 0.041 nM
Cc1nc(-c2ccc(NC(=O)N[C@@H](CC(C)C)C(=O)N(C)N(C)C#N)cc2)no1 CHEMBL1651349 Ki 0.045 nM
CN1CCN(c2ccc(CCNC(=O)c3cnc(C#N)nc3NC3CCCCC3)cc2)CC1 CHEMBL219536 IC50 0.047 nM
C[C@@H](CC1CCCCC1)OC(=O)C1CCN1C#N CHEMBL183812 IC50 0.048 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N(C)N(C)C#N CHEMBL608115 Ki 0.064 nM
CN(C#N)N(C)C(=O)[C@H](CC1CCCCC1)NC(=O)OCc1ccccc1 CHEMBL1651352 Ki 0.071 nM
CCCC[C@H](NC(=O)O[C@H](Cn1ccc(-c2ccc(C(F)(F)F)cc2)n1)C(C)(C)C)C(=O)C(=O)Nc1ccn[nH]1 CHEMBL234367 IC50 0.072 nM
CC(C)C[C@H](NC(=O)NCc1ccc(-c2noc(-c3cccs3)n2)cc1)C(=O)N(C)N(C)C#N CHEMBL1651357 Ki 0.072 nM
COc1ccc(-c2ccc([C@H](N[C@@H](CC(C)C)C(=O)NCC#N)C(F)(F)F)cc2)cc1 CHEMBL203944 IC50 0.1 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccccc2F)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL382576 IC50 0.1 nM
CCCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL92708 IC50 0.11 nM
Cc1nc(-c2ccc(CNC(=O)N[C@@H](CC(C)C)C(=O)N(C)N(C)C#N)cc2)no1 CHEMBL1651356 Ki 0.11 nM
CC(C)C[C@H](NC(=O)c1ccc(-c2ccccc2)cc1)C(=O)NC1(C#N)CCS(=O)(=O)CC1 CHEMBL4228926 IC50 0.11 nM
CCCC[C@H](NC(=O)O[C@H](Cc1nnc(-c2ccc(C(F)(F)F)cc2)o1)C(C)(C)C)C(=O)C(=O)NN1CCOC1=O CHEMBL365822 pIC50 0.1288 nM
CCCC[C@@H](C=O)NC(=O)O[C@@H](CC)Cc1ccccc1 CHEMBL114462 IC50 0.13 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@H]1C[C@H](C)CN(S(=O)(=O)c2ccccn2)CC1=O CHEMBL205172 Ki app 0.14 nM
CN(C#N)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 CHEMBL604281 Ki 0.14 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@H]1CCCN(S(=O)(=O)c2ccccn2)CC1=O CHEMBL286364 Ki 0.16 nM
CC(C)(F)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@H]1CCCN(S(=O)(=O)c2ccccn2)CC1=O CHEMBL474438 IC50 0.16 nM
CN(C#N)N(C)C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1 CHEMBL1651353 Ki 0.16 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@@H]1CCCN(S(=O)(=O)c2ccccn2)CC1=O CHEMBL31674 Ki 0.16 nM
CC[C@H](C)[C@H](NC(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)OC)C(C)C CHEMBL2028910 Ki 0.18 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL481611 Ki 0.18 nM
CC(C)C[C@H](Nc1cscc1-c1ccc(N2CCNCC2)cc1)C(=O)NCC#N CHEMBL182956 IC50 0.2 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccccc2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL204792 IC50 0.2 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccsc2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL381621 IC50 0.2 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(S(N)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL207554 IC50 0.2 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL437501 IC50 0.2 nM
CSc1ccc(-c2ccc([C@H](N[C@@H](CC(C)C)C(=O)NCC#N)C(F)(F)F)cc2)cc1 CHEMBL437694 IC50 0.2 nM
CSc1ccc(-c2nc(C)sc2C2CCC(F)(F)CC2C(=O)NCC#N)cc1 CHEMBL245580 IC50 0.2 nM
CSCC[C@@H](C#N)NC(=O)[C@H](CC(C)C)N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F CHEMBL250501 IC50 0.2 nM
CC(F)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC(C#N)(C1CC1)C1CC1 CHEMBL399733 IC50 0.2 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(C(C)(C)O)cc2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL597018 IC50 0.2 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(C3(O)CC3)cc2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL605122 IC50 0.2 nM
C[C@H](C(N)=O)c1ccc(-c2ccc([C@H](N[C@@H](CC(C)(C)F)C(=O)NC3(C#N)CC3)C(F)(F)F)cc2)cc1 CHEMBL597426 IC50 0.2 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(C3(C(N)=O)CC3)cc2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL598502 IC50 0.2 nM
CC(C)CN(NC(=O)c1ccc(CN2CCN(C)CC2)cc1)c1nc(C#N)ncc1Br CHEMBL1215628 IC50 0.2 nM
CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1[nH]ncc1-c1ccccc1 CHEMBL154579 IC50 0.21 nM
CCCC[C@H](NC(=O)O[C@H](Cc1nnc(-c2ccccc2)o1)C(C)(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL186778 pIC50 0.2399 nM
CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1[nH]ncc1Br CHEMBL157072 IC50 0.24 nM
CN1CCN(c2nc(-c3ccc(C(=O)NC4(C(=O)NCC#N)CCCCC4)cc3)cs2)CC1 CHEMBL426819 IC50 0.25 nM
CCCCC(C=O)NC(=O)C(CC(C)C)NC(=O)OCc1ccc(Br)cc1 CHEMBL2316303 IC50 0.25 nM
CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1[nH]nc2cccc(F)c12 CHEMBL345569 IC50 0.26 nM
CSc1ccc(-c2ccccc2[C@@H]2CCC(F)(F)C[C@H]2C(=O)NCC#N)cc1 CHEMBL201782 IC50 0.28 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2nccs2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL381758 IC50 0.3 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccncc2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL206024 IC50 0.3 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2cccc(S(C)(=O)=O)c2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL206912 IC50 0.3 nM
Cc1ccc(-c2ccc([C@H](N[C@@H](CC(C)C)C(=O)NCC#N)C(F)(F)F)cc2)cc1 CHEMBL208278 IC50 0.3 nM
CC(C)(C)CNc1nc(C#N)ncc1C(=O)NCCc1ccc(N2CCCC2)cc1 CHEMBL374695 IC50 0.3 nM
CSc1ccc(-c2ccccc2C2CCC(F)(F)CC2C(=O)NCC#N)cc1 CHEMBL201914 IC50 0.3 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL249495 IC50 0.3 nM
C[C@@H](C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC(C#N)(C1CC1)C1CC1)C(F)(F)F CHEMBL398910 IC50 0.3 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC(C#N)(C1CC1)C1CC1 CHEMBL252383 IC50 0.3 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(C3(O)CC3)cn2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL597627 IC50 0.3 nM
Cc1csc(-c2ccc([C@H](N[C@@H](CC(C)(C)F)C(=O)NC3(C#N)CC3)C(F)(F)F)cc2)n1 CHEMBL598298 IC50 0.3 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)F)C(=O)NCC#N CHEMBL1669438 IC50 0.3 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(C3(C(N)=O)CC3)cc2F)cc1)C(F)F)C(=O)NC1(C#N)CC1 CHEMBL1669441 IC50 0.3 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(C3(C(N)=O)CC3)cc2F)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL1669442 IC50 0.3 nM
CCCC[C@@H](/C=N/NC(=O)N1CCOCC1)NC(=O)O[C@H](Cc1ccccc1)C(C)C CHEMBL203663 IC50 0.33 nM
CCCC[C@H](NC(=O)O[C@H](CN1CCN(c2ccc(C(F)(F)F)cc2)C1=O)C(C)(C)C)C(=O)C(=O)Nc1ccn[nH]1 CHEMBL191178 pIC50 0.3388 nM
CCCC[C@@H](C=O)NC(=O)OC1(Cc2ccccc2)CCCC1 CHEMBL117658 IC50 0.35 nM
C[C@H]1CN(C(=O)[C@@H](NC(=O)c2ccc(N3CCN(C)CC3)cc2)C2CCCC2)[C@@H]2C(=O)CO[C@@H]21 CHEMBL3640077 Ki 0.35 nM
CCCC[C@H](NC(=O)O[C@H](Cc1nnc(-c2ccc(F)cc2)o1)C(C)(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL188438 pIC50 0.3715 nM
N#CCNC(=O)C1(NC(=O)c2ccc(-c3ccc(N4CCNCC4)cc3)cc2)CCCCC1 CHEMBL371133 IC50 0.4 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2cccc3[nH]ccc23)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL207891 IC50 0.4 nM
CSc1ccc(-c2cn(C)nc2C2CCC(F)(F)CC2C(=O)NCC#N)cc1 CHEMBL395698 IC50 0.4 nM
C[C@H](C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC(C#N)(C1CC1)C1CC1)C(F)(F)F CHEMBL252571 IC50 0.4 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc([C@@H](O)C(F)F)cc2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL603899 IC50 0.4 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc([C@H](O)C(F)F)cc2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL599272 IC50 0.4 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc3ncccc3c2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL605341 IC50 0.4 nM
CC[C@H]1CN(C(=O)[C@@H](NC(=O)c2ccc(N3CCN(C)CC3)cc2)C2CCCC2)[C@@H]2C(=O)CO[C@H]12 CHEMBL3640090 Ki 0.4 nM
CCCC[C@H](NC(=O)O[C@H](Cc1nnc(-c2ccc(C(F)(F)F)cc2)o1)C(C)(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL363773 pIC50 0.4074 nM
CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1ccn(C)n1 CHEMBL156764 IC50 0.41 nM
CCCC[C@H](NC(=O)O[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2)CC1(C)C)C(=O)C(=O)Nc1cc[nH]n1 CHEMBL1092804 pIC50 0.4169 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)N(C(=O)Nc2ccc(C(F)(F)F)cc2)CC1(C)C)C(=O)C(=O)Nc1cc[nH]n1 CHEMBL205659 IC50 0.42 nM
CC(C)C[C@H](NC(=O)c1ccc(-c2csc(N3CCN(C)CC3)n2)cc1)C(=O)N1C[C@@H](C(F)F)[C@H]2OCC(=O)[C@H]21 CHEMBL3640082 Ki 0.45 nM
CC(C)[C@H]1CN(C(=O)[C@@H](NC(=O)c2ccc(N3CCN(C)CC3)cc2)C2CCCC2)[C@@H]2C(=O)CO[C@H]12 CHEMBL3640091 Ki 0.45 nM
CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N(C)N(C)C#N CHEMBL1651351 Ki 0.46 nM
CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1[nH]ncc1C CHEMBL154959 IC50 0.47 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC1CCN(S(=O)(=O)c2ccc(Oc3ccccc3)cc2)CC1=O CHEMBL113724 Ki app 0.5 nM
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H]1C(=O)N2CCS(=O)(=O)[C@@H]12)OCc1ccccc1 CHEMBL326093 IC50 0.5 nM
CCCC[C@@H](C=O)NC(=O)O[C@H](Cc1ccccc1)C(C)C CHEMBL113948 IC50 0.5 nM
N#CCNC(=O)[C@@H]1CCCC[C@H]1/C=C\c1ccccc1 CHEMBL201479 IC50 0.5 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2cccc(F)c2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL207769 IC50 0.5 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(C3(C(N)=O)CC3)cn2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL598299 IC50 0.5 nM
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2c2nn(-c3ccc(F)cc3)cc2-c2ccc(N3CCS(=O)(=O)CC3)cc2)CC1 CHEMBL5200434 IC50 0.5 nM
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2c2oc(-c3ccc(F)cc3)nc2-c2ccc(N3CCS(=O)(=O)CC3)cc2)CC1 CHEMBL5178296 IC50 0.5 nM
N#CC1(NC(=O)[C@@H]2CC(Cl)(Cl)CC[C@H]2c2nn(CC(F)(F)F)cc2-c2ccc(N3CCS(=O)(=O)CC3)cc2)CC1 CHEMBL5176632 IC50 0.5 nM
N#CC1(NC(=O)[C@@H]2CC(F)(F)CC[C@H]2c2nn(-c3ccc(F)cc3)cc2-c2ccc(N3CCS(=O)(=O)CC3)cc2)CC1 CHEMBL5192725 IC50 0.5 nM
CCCC[C@@H](C=O)NC(=O)OC(C(C)C)C(C)C CHEMBL118016 IC50 0.56 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(O)S(=O)(=O)[O-] CHEMBL3427166 IC50 0.56 nM
CSc1ccc(-c2ccccc2C2CCC(Cl)(Cl)CC2C(=O)NCC#N)cc1 CHEMBL383612 IC50 0.58 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC1CN(C(=O)[C@H](CC(C)C)N(C)C(=O)OCc2ccccc2)CC1=O CHEMBL348842 Ki app 0.6 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(F)cc2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL205929 IC50 0.6 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccccc1 CHEMBL399361 IC50 0.6 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC(C#N)c1ccccc1 CHEMBL252179 IC50 0.6 nM
CCCN1CCN(c2ccc(C(=O)NC3(C(=O)NCC#N)CCCCC3)cc2)CC1 CHEMBL371064 IC50 0.6 nM
CC(C)C[C@H](NC(=O)c1ccc(-c2csc(N3CCN(C)CC3)n2)cc1)C(=O)N1C[C@H](C)[C@H]2OCC(=O)[C@H]21 CHEMBL3640081 Ki 0.6 nM
C#C[C@@H]1CN(C(=O)[C@@H](NC(=O)c2ccc(-c3nc(N4CCN(C)CC4)sc3F)cc2)C2CCCC2)[C@@H]2C(=O)CO[C@H]12 CHEMBL3661028 Ki 0.6 nM
C#C[C@@H]1CN(C(=O)[C@@H](NC(=O)c2ccc(-c3nc(N4CCN(C)CC4)sc3F)cc2)C2CCCC2)C2C(=O)COC21 CHEMBL4111241 Ki 0.6 nM
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2c2nc(-c3ccc(F)cc3)sc2-c2ccc(N3CCS(=O)(=O)CC3)cc2)CC1 CHEMBL5187327 IC50 0.6 nM
CS(=O)(=O)N1CC(c2ccc(-c3cn(CC(F)(F)F)nc3[C@@H]3CCC(F)(F)C[C@H]3C(=O)NC3(C#N)CC3)cc2)C1 CHEMBL5192453 IC50 0.6 nM
CS(=O)(=O)c1ccc(-c2cn(CC(F)(F)F)nc2[C@@H]2CCC(Cl)(Cl)C[C@H]2C(=O)NC2(C#N)CC2)cc1 CHEMBL523352 IC50 0.62 nM
CC(C)C[C@@H](C(=O)N(C)N(C)C#N)N(C)C(=O)c1ccc(-c2noc(-c3cccs3)n2)cc1 CHEMBL1651362 Ki 0.63 nM
CCCC[C@H](NC(=O)O[C@H](Cc1nnc(-c2ccc(F)cc2)o1)C(C)(C)C)C(=O)C(=O)N[C@H]1CCCNC1=O CHEMBL1087934 pIC50 0.6457 nM
CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1cc(-c2ccccc2)[nH]n1 CHEMBL345982 IC50 0.65 nM
CC(C)CS(=O)(=O)C[C@H](NC(=O)c1ccccc1)C(=O)N(C)N(C)C#N CHEMBL2153161 Ki 0.66 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NNC(=O)NNC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL115357 Ki app 0.7 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NNC(=O)NNC(=O)C(CC(C)C)NC(=O)OCc1ccccc1 CHEMBL2316588 Ki(app) 0.7 nM
CC(C)(C)c1nc([C@@H]2CCCC[C@H]2C(=O)NCC#N)c(-c2ccc(N3CCS(=O)(=O)CC3)cc2)s1 CHEMBL3586465 IP 0.7 nM
CC(C)C[C@H](NC(=O)c1ccc(-c2csc(N3CCN(C)CC3)n2)cc1)C(=O)N1C[C@@H](C)[C@H]2OCC(=O)[C@H]21 CHEMBL3640080 Ki 0.7 nM
CC(C)C[C@H](NC(=O)c1ccc(-c2csc(N3CCN(C)CC3)n2)cc1)C(=O)N1C[C@H](C(F)F)[C@H]2OCC(=O)[C@H]21 CHEMBL3640083 Ki 0.7 nM
COc1cccc(-n2cc(-c3ccc(N4CCS(=O)(=O)CC4)cc3)c([C@@H]3CCCC[C@H]3C(=O)NC3(C#N)CC3)n2)c1 CHEMBL5203617 IC50 0.7 nM
N#CC1(NC(=O)[C@@H]2CC(F)(F)CC[C@H]2c2nn(CC(F)(F)F)cc2-c2ccc(N3CCS(=O)(=O)CC3)cc2)CC1 CHEMBL5177796 IC50 0.7 nM
CCCC[C@H](NC(=O)OC(C(C)(C)C)C(C)(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL354473 pIC50 0.7079 nM
CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1cc(C)[nH]n1 CHEMBL154818 IC50 0.71 nM
O=C[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 CHEMBL177914 Ki app 0.74 nM
N#Cc1ncc(C(=O)NCCc2ccc(N3CCCC3)cc2)c(NC2CCCCC2)n1 CHEMBL217930 IC50 0.75 nM
CC(C)C[C@H](NC(=O)c1ccc(N2CCN(C)CC2)cc1)C(=O)N1C[C@H](C)[C@H]2OCC(=O)[C@H]21 CHEMBL3640075 Ki 0.75 nM
CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1cc[nH]n1 CHEMBL154862 IC50 0.77 nM
CCCC[C@H](NC(=O)O[C@H](CCCc1ccccc1)C(C)(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL163286 IC50 0.79 nM
CCC[C@H](NC(=O)OCc1ccccc1)C(=O)NNC(=O)NNC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL126820 Ki app 0.8 nM
CC(C)C[C@H](N[C@@H](c1ccc(Br)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL204277 IC50 0.8 nM
CC(C)CC(C(=O)NCC#N)c1cccc(-c2cccc(-c3csc(N4CCNCC4)n3)c2)c1 CHEMBL212907 Ki 0.8 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)F)C(=O)NC1(C#N)CC1 CHEMBL1669436 IC50 0.8 nM
CC(C)C[C@H](NC(=O)c1ccc(N2CCN(C)CC2)cc1)C(=O)N1C[C@H](C(F)F)[C@H]2OCC(=O)[C@H]21 CHEMBL3640079 Ki 0.8 nM
CC[C@H]1CN(C(=O)[C@@H](NC(=O)c2ccc(N3CCN(C)CC3)cc2)C(C)(C)C)[C@@H]2C(=O)CO[C@H]12 CHEMBL3640086 Ki 0.8 nM
CC(C)[C@H]1CN(C(=O)[C@@H](NC(=O)c2ccc(N3CCN(C)CC3)cc2)C(C)(C)C)[C@@H]2C(=O)CO[C@H]12 CHEMBL3640087 Ki 0.8 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)N(C(=O)c2nc3ccccc3s2)CC1(C)C)C(=O)C(=O)Nc1cc[nH]n1 CHEMBL206515 IC50 0.81 nM
CCCC[C@H](NC(=O)OCC1(Cc2ccc(F)cc2)CCC1)C(=O)C(=O)Nc1ccn[nH]1 CHEMBL185097 IC50 0.83 nM
CCCCC(NC(=O)OCC1(c2ccc(F)cc2)CCC1)C(=O)C(=O)Nc1ccn[nH]1 CHEMBL2316304 IC50 0.83 nM
CCCC[C@H](NC(=O)O[C@@H](Cc1nnc(-c2ccccc2)o1)C(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL1087763 pIC50 0.8318 nM
CC[C@H](C)[C@H](NC(=O)NNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)OC)C(C)C CHEMBL2028921 Ki 0.86 nM
CCCC[C@@H](C=O)NC(=O)OC(CCC)CCC CHEMBL326164 IC50 0.87 nM
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N(C)N(C)C#N CHEMBL1651242 Ki 0.87 nM
CC(C)C[C@H](NC(=O)c1ccc2ccccc2n1)C(=O)N[C@H]1CCCN(S(=O)(=O)c2ccccn2)CC1=O CHEMBL433985 Ki app 0.89 nM
CC(C)C[C@H](NC(c1ccc(Br)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL372979 IC50 0.9 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(C#N)cc2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL380425 IC50 0.9 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@@H](C)C#N CHEMBL250294 IC50 0.9 nM
CC(C)[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccc(C#N)cc1F CHEMBL1288530 IC50 0.9 nM
CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1[nH]ncc1C#N CHEMBL347004 IC50 0.91 nM
CCCC[C@@H](/C=N/NC(=O)N1CCOCC1)NC(=O)O[C@@H](C)Cc1ccccc1 CHEMBL204605 IC50 0.94 nM
CCC[C@H](NC(=O)C1(NC(=O)c2ccc(N(C)C)cc2)CCCCC1)C(=O)c1nnc(-c2ccco2)o1 CHEMBL209293 Ki app 0.95 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NNC(=O)NNC(=O)[C@H](C)NC(=O)OCc1ccccc1 CHEMBL126352 Ki app 1.0 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)N(C(=O)c2nnc(C(F)(F)F)s2)CC1(C)C)C(=O)C(=O)Nc1cc[nH]n1 CHEMBL383211 IC50 1.0 nM
CSc1ccc(-c2ncccc2C2CCC(F)(F)CC2C(=O)NCC#N)cc1 CHEMBL391959 IC50 1.0 nM
CSc1ccc(-c2cnccc2C2CCC(F)(F)CC2C(=O)NCC#N)cc1 CHEMBL247587 IC50 1.0 nM
CC(C)(C)Cn1c(CN2CCN(c3ccc(F)cc3)CC2)cc2cnc(C#N)nc21 CHEMBL399054 IC50 1.0 nM
COc1ccc(Cc2cc3cnc(C#N)nc3n2CC(C)(C)C)cc1 CHEMBL250590 IC50 1.0 nM
CC(C)C(NC(=O)OCc1ccccc1)C(=O)N1CCCCN1C#N CHEMBL493039 IC50 1.0 nM
N#Cc1nc(NC2CCCCC2)nc(N2CCNCC2)n1 CHEMBL1084679 IC50 1.0 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)F)C(=O)NC1(C#N)CC1 CHEMBL1669437 IC50 1.0 nM
CC(C)C[C@H](NC(=O)c1ccco1)C(=O)N[C@H]1CC[C@@H](C)N(S(=O)(=O)c2ccccn2)CC1=O CHEMBL1807649 IC50 1.0 nM
COc1ccccc1C(C#N)NC(=O)[C@@H]1CCCC[C@H]1C(=O)N1CCN(Cc2ccc(F)cc2)CC1 CHEMBL2164670 IC50 1.0 nM
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2C(=O)N2CCc3[nH]c4ncccc4c3C2)CC1 CHEMBL2163360 IC50 1.0 nM
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2C(=O)N2CCc3[nH]c4ccccc4c3C2)CC1 CHEMBL2164682 IC50 1.0 nM
C[C@@H]1CN(C(=O)[C@@H](NC(=O)c2ccc(N3CCN(C)CC3)cc2)C2CCCC2)[C@@H]2C(=O)CO[C@H]12 CHEMBL3640074 Ki 1.0 nM
CC(C)(C)CN(Cc1ccc(/C=C/CN2CCC(N3CCCCC3)CC2)cc1)c1ccnc(C#N)n1 CHEMBL4086667 IC50 1.0 nM
CC(C)C[C@H](NC(=O)c1ccc(CN2CCN(C)CC2)cc1)C(=O)NC1(C#N)CCS(=O)(=O)CC1 CHEMBL4228143 IC50 1.0 nM
N#CC1(NC(=O)[C@@H]2CC(F)(F)CC[C@H]2c2nn(CC(F)(F)F)cc2-c2ccc(-c3ncco3)cc2)CC1 CHEMBL5177683 IC50 1.0 nM
N#CC1(NC(=O)[C@@H]2CC(Cl)(Cl)CC[C@H]2c2nn(CC(F)(F)F)cc2-c2ccc(C(=O)N3CCOCC3)cc2)CC1 CHEMBL5197995 IC50 1.0 nM
CCCC[C@H](NC(=O)O[C@H](CCc1ccccc1)C(C)(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL349045 pIC50 1.096 nM
CCCC[C@@H](C=O)NC(=O)OC(CC(C)C)CC(C)C CHEMBL115756 IC50 1.1 nM
CCCC[C@@H](/C=N/NC(=O)N1CCc2ccccc21)NC(=O)OC1(Cc2ccccc2)CCCC1 CHEMBL426308 IC50 1.1 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(F)c(F)c2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL205504 IC50 1.1 nM
CC(C)(C)Cn1c(Cc2ccc(NS(=O)(=O)CC(F)(F)F)cc2)cc2cnc(C#N)nc21 CHEMBL399842 IC50 1.1 nM
CC(C)(C)Cn1c(Cc2ccc(-c3ccc4c(c3)OCO4)cc2)cc2cnc(C#N)nc21 CHEMBL250591 IC50 1.1 nM
C[C@H]1CN(C(=O)[C@@H](NC(=O)c2ccc(N3CCN(C)CC3)cc2)C(C)(C)C)[C@@H]2C(=O)CO[C@@H]21 CHEMBL3640076 Ki 1.1 nM
C#C[C@@H]1CN(C(=O)[C@H](CC(C)C)NC(=O)c2ccc(-c3nc(N4CCN(C)CC4)sc3F)cc2)[C@@H]2C(=O)CO[C@H]12 CHEMBL3661025 Ki 1.1 nM
CC(C)CC(NC(=O)c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(=O)N(C)N(C)C#N CHEMBL4541720 Ki 1.14 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(-c3ccc(S(C)(=O)=O)cc3)cc2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL382820 IC50 1.2 nM
CC(C)(C)Cn1c(Cc2ccccc2)cc2cnc(C#N)nc21 CHEMBL249979 IC50 1.2 nM
CC(C)C[C@H](NC(=O)N1CCOCC1)C(=O)N[C@H](/C=C/S(=O)(=O)c1ccccc1)CCc1ccccc1 CHEMBL486232 Ki 1.2 nM
CC[C@@H]1CN(C(=O)[C@@H](NC(=O)c2ccc(N3CCN(C)CC3)cc2)C2CCCC2)[C@@H]2C(=O)CO[C@H]12 CHEMBL3640088 Ki 1.2 nM
CC(C)CC(C(=O)NCC#N)c1cccc(-c2cccc(-c3csc(N4CCN(C)CC4)n3)c2)c1 CHEMBL213930 Ki 1.3 nM
CC(C)C[C@@H](C(=O)NCC#N)c1cccc(-c2cccc(-c3csc(N4CCN(C(C)(C)C)CC4)n3)c2)c1 CHEMBL212879 Ki 1.3 nM
CC(C)C[C@H](NC(=O)c1ccc(-c2ccccc2)cc1)C(=O)NC1(C#N)CC1 CHEMBL4227295 IC50 1.3 nM
CC(C)C[C@@H](C(=O)NCC(=O)CNS(=O)(=O)c1ccc(Oc2ccccc2)cc1)c1cccc(-c2ccccc2)c1 CHEMBL99890 Ki 1.4 nM
CC(C)C[C@H](C(=O)NCC(=O)CNS(=O)(=O)c1ccc(Oc2ccccc2)cc1)c1cccc(-c2ccccc2)c1 CHEMBL113805 Ki app 1.4 nM
CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL64925 Ki app 1.4 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@@H]1CC[C@@H](C)N(S(=O)(=O)c2ccccn2)CC1=O CHEMBL203224 Ki app 1.4 nM
C[C@H](NC(=O)O[C@H](Cn1cnc2cc(Cl)c(Cl)cc21)C(C)(C)C)C(=O)CNS(=O)(=O)c1ccccn1 CHEMBL232712 IC50 1.4 nM
CC(C)C[C@H](NC(=O)C1OC1C(=O)O)C(=O)NCCCCNC(=N)N CHEMBL189382 Ki 1.4 nM
CCCC[C@@H](C=O)NC(=O)O[C@@H](CCC)Cc1ccccc1 CHEMBL114844 IC50 1.5 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@@H]1C(=O)CN(S(=O)(=O)c2ccccn2)CC[C@H]1C CHEMBL203845 Ki app 1.5 nM
CC(C)C[C@H](N[C@@H](c1ccc(C(=O)c2ccccc2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL426493 IC50 1.5 nM
CN1CCN(Cc2ccc(Cc3cc4cnc(C#N)nc4n3C3CCCCC3)cc2)CC1 CHEMBL398719 IC50 1.5 nM
CS(=O)(=O)c1ccc(-c2ccc([C@H](N[C@@H](CC(F)(F)F)C(=O)NC(C#N)(C3CC3)C3CC3)C(F)(F)F)cc2)cc1 CHEMBL252784 IC50 1.5 nM
CC[C@H](C)[C@H](NC(=O)c1ccc(N2CCN(C)CC2)cc1)C(=O)N1C[C@@H](C)[C@H]2OCC(=O)[C@H]21 CHEMBL3640073 Ki 1.5 nM
CC(C)[C@@H]1CN(C(=O)[C@@H](NC(=O)c2ccc(N3CCN(C)CC3)cc2)C2CCCC2)[C@@H]2C(=O)CO[C@@H]21 CHEMBL3640089 Ki 1.5 nM
COC1=CC(=O)N(C(=O)/C=C/[C@H](CCc2ccccc2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)N(C)C)[C@H]1Cc1c[nH]c2ccccc12 CHEMBL4596647 IC50 1.5 nM
CCCC[C@H](NC(=O)O[C@@H]1CN(C(=O)c2ccc3ccccc3c2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL1087814 pIC50 1.585 nM
CC(C)C[C@@H](CN1CC(=O)C(NC(=O)[C@H](CC(C)C)NC(=O)c2ccc3cccnc3c2)C1)NC(=O)OCc1ccccc1 CHEMBL350591 Ki app 1.6 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)NCC(=O)CNS(=O)(=O)c1ccccn1 CHEMBL31381 Ki 1.6 nM
CCCC[C@H](NC(=O)OCC(C)(C)CC)C(=O)C(=O)Nc1cc[nH]n1 CHEMBL185533 IC50 1.6 nM
CCCC[C@H](NC(=O)OCC1(CC)CCCCC1)C(=O)C(=O)Nc1[nH]nc2cc(Cl)ccc12 CHEMBL183788 IC50 1.6 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)N(C(=O)c2ccc3ccccc3c2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL205759 IC50 1.6 nM
CCOC(=O)N1CC(=O)C(NC(=O)[C@H](CC(C)(C)F)N[C@@H](c2ccc(-c3ccc(S(C)(=O)=O)cc3)cc2)C(F)(F)F)C1 CHEMBL443434 IC50 1.6 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(C(O)C(F)(F)F)cc2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL1669440 IC50 1.6 nM
C#C[C@@H]1CN(C(=O)[C@H](CC(C)C)NC(=O)c2ccc(-c3csc(N4CCN(C)CC4)n3)cc2)[C@@H]2C(=O)CO[C@H]12 CHEMBL3661024 Ki 1.6 nM
CCCC[C@H](NC(=O)O[C@@H]1CN(C(=O)c2ccc3cc[nH]c3c2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL1083217 pIC50 1.698 nM
CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1[nH]ncc1C(=O)OCC CHEMBL155941 IC50 1.7 nM
N#CCNC(=O)[C@@H]1CCCC[C@H]1CCc1ccccc1 CHEMBL371545 IC50 1.7 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)N(C(=O)c2ccc3[nH]ccc3c2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL426859 IC50 1.7 nM
CCC[C@H](NC(=O)C1(NC(=O)c2ccc(OC(F)(F)F)cc2)CCCCC1)C(=O)c1nnc(-c2ccco2)o1 CHEMBL209215 Ki app 1.7 nM
CC(C)(C)Cn1c(CN2C(=O)C3(CCNCC3)c3cc(F)ccc32)cc2cnc(C#N)nc21 CHEMBL400395 IC50 1.7 nM
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2c2nc(-c3cccc(C4CCOCC4)c3)sc2-c2ccc(N3CCS(=O)(=O)CC3)cc2)CC1 CHEMBL3586466 IP 1.7 nM
CC(C)C[C@H](NC(=O)c1ccc(N2CCN(C)CC2)cc1)C(=O)N1C[C@@H](C(F)F)[C@H]2OCC(=O)[C@H]21 CHEMBL3640078 Ki 1.7 nM
O=C(N[C@@H](Cc1cccs1)C(=O)N[C@@H]1C(=O)N2CCS(=O)(=O)[C@@H]12)OCc1ccccc1 CHEMBL113706 IC50 1.8 nM
CCCC[C@@H](C=O)NC(=O)O[C@@H](C)Cc1ccccc1 CHEMBL114161 IC50 1.8 nM
C[C@@H](CC1CCCCC1)OC(=O)C1CCCN1C#N CHEMBL180839 IC50 1.8 nM
CCCC[C@H](NC(=O)OCC1(CC)CCCC1)C(=O)C(=O)Nc1cc[nH]n1 CHEMBL424982 IC50 1.8 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC1CCCN(S(=O)(=O)c2ccccn2)CC1=O CHEMBL503774 IC50 1.8 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CCCCC2)CC1)C(=O)NC1(C#N)CC1 CHEMBL3640731 Ki 1.8 nM
CCN(CC)Cc1ccc(/C=C/c2ccccc2C(=O)NC(Cc2ccccc2)C(=O)C(N)=O)cc1 CHEMBL4066494 Ki 1.8 nM
CCN(CC)c1ccc(/C=C/c2ccccc2C(=O)NC(Cc2ccccc2)C(=O)C(N)=O)cc1 CHEMBL5195850 Ki 1.8 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC1CCN(C(=O)[C@H](CC(C)C)N(C)C(=O)OCc2ccccc2)CC1=O CHEMBL162175 Ki app 1.9 nM
CCCC[C@H](NC(=O)OCC1(CC)CCC1)C(=O)C(=O)Nc1cc[nH]n1 CHEMBL363949 IC50 1.9 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(C(O)C(F)(F)F)cc2)cc1)C(F)F)C(=O)NC1(C#N)CC1 CHEMBL1669439 IC50 1.9 nM
N#CN1CC[C@@H](NS(=O)(=O)c2cc(Br)ccc2Br)C1 CHEMBL1672427 pIC50 1.995 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC1CN(C(=O)[C@H](CC(C)C)NC(=O)OCc2ccccc2)CC1=O CHEMBL100563 Ki 2.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC1CCCN(C(=O)[C@H](CC(C)C)NC(=O)OCc2ccccc2)CC1=O CHEMBL31947 Ki 2.0 nM
CCCC[C@@H](C=O)NC(=O)OC1(Cc2ccccc2)CCCCC1 CHEMBL117144 IC50 2.0 nM
CCC(C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@H](C=O)Cc1cc2ccccc2[nH]1 CHEMBL197958 Ki app 2.0 nM
CSc1ccc(-c2c(C3CCC(F)(F)CC3C(=O)NCC#N)nnn2Cc2ccccc2)cc1 CHEMBL245579 IC50 2.0 nM
N#CCNC(=O)C1CC(F)(F)CCC1c1cnccc1-c1ccc(SCF)cc1 CHEMBL245759 IC50 2.0 nM
N#Cc1nc(NC2CC3CCC2C3)c(N)c(N2CCOCC2)n1 CHEMBL470915 IC50 2.0 nM
CC(C)[C@H](N[C@@H](c1ccc(-c2ccc([C@@H](O)C(F)F)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccc(C#N)cc1F CHEMBL1288532 IC50 2.0 nM
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2C(=O)N2CCc3[nH]c4c(OC(F)(F)F)cccc4c3C2)CC1 CHEMBL2163589 IC50 2.0 nM
N#Cc1cccc2c3c([nH]c12)CCN(C(=O)[C@@H]1CCCC[C@H]1C(=O)NC1(C#N)CC1)C3 CHEMBL2163585 IC50 2.0 nM
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2C(=O)N2CCc3[nH]c4c(Cl)cccc4c3C2)CC1 CHEMBL2163582 IC50 2.0 nM
N#CCNC(=O)[C@@H]1CCCC[C@H]1C(=O)N1CCc2ccccc2C1 CHEMBL2164674 IC50 2.0 nM
CCCC[C@H](NC(=O)O[C@@H]1CN(C(=O)OCc2ccc(-c3ccccc3)cc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL1077004 pIC50 2.089 nM
CCCC[C@@H](C=O)NC(=O)OC(CC)(CC)Cc1ccccc1 CHEMBL116779 IC50 2.1 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)N(C(=O)OCc2ccc(-c3ccccc3)cc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL436747 IC50 2.1 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)N(C(=O)Nc2ccc(C(F)(F)F)cc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL206559 IC50 2.1 nM
CCCC[C@H](NC(=O)O[C@H](Cn1ccc(-c2ccc(C(F)(F)F)cc2)n1)C(C)(C)C)C(=O)CNc1cccc(F)n1 CHEMBL232911 IC50 2.1 nM
CC[C@H](C)[C@H](NC(=O)NNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1)[C@@H](C)CC)C(=O)N[C@H](C(=O)OC)C(C)C CHEMBL2028911 Ki 2.12 nM
CC(C)C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)NNC(=O)N[C@H](C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C CHEMBL2028909 Ki 2.13 nM
CC(=O)O[C@@H]1NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL292513 Ki 2.2 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N1CC(=O)C(NC(=O)[C@@H](CC(C)C)NC(=O)OCc2ccccc2)C1 CHEMBL29483 Ki 2.3 nM
N#CCNC(=O)C1(NC(=O)c2ccc(-c3csc(N4CCOCC4)n3)cc2)CCCCC1 CHEMBL199358 IC50 2.3 nM
CC(C)C[C@H](N[C@@H](c1ccc(Oc2ccccc2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL206913 IC50 2.3 nM
N#Cc1ncc2cc(Cc3ccc(Cl)cc3)n(C3CCCCC3)c2n1 CHEMBL249367 IC50 2.3 nM
CCCC[C@@H](C=O)NC(=O)OC1(Cc2ccccc2)CCC1 CHEMBL116724 IC50 2.4 nM
CC(C)C[C@H](NC(c1ccc(Br)cc1)C(F)(F)C(F)(F)F)C(=O)NCC#N CHEMBL372046 IC50 2.4 nM
CC[C@H](C)[C@H](NC(=O)NNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C CHEMBL2028919 Ki 2.45 nM
O=C(N[C@@H](Cc1cccnc1)C(=O)N[C@@H]1C(=O)N2CCS(=O)(=O)[C@@H]12)OCc1ccccc1 CHEMBL117928 IC50 2.5 nM
CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL84691 IC50 2.5 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)NCC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL194068 IC50 2.5 nM
CC(C)C[C@H](NC(c1ccc(Br)cc1)c1ccc(S(C)(=O)=O)cc1)C(=O)NCC#N CHEMBL193813 IC50 2.5 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@H]1CC[C@H](C)N(S(=O)(=O)c2ccccn2)CC1=O CHEMBL377713 Ki app 2.5 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)C1(NC(=O)c2ccc(-c3csc(N4CCN(C)CC4)n3)cc2)CCCCC1 CHEMBL1086008 Ki 2.5 nM
CC(C)C[C@H](NC(=O)c1ccc(N2CCN(C)CC2)cc1)C(=O)N1C[C@@H](C)[C@H]2OCC(=O)[C@H]21 CHEMBL3640072 Ki 2.5 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC1CCN(C(=O)[C@H](CC(C)C)NC(=O)OCc2ccccc2)CC1=O CHEMBL118449 Ki app 2.6 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC(NC(=O)[C@@H](CC(C)C)NC(=O)OCc2ccccc2)C(=O)C1 CHEMBL281086 Ki 2.6 nM
CSc1ccc(-c2ccccc2[C@@H]2CCCC[C@H]2C(=O)NCC#N)cc1 CHEMBL201178 IC50 2.6 nM
Cc1noc(-c2ccc([C@H](N[C@@H](CC(C)C)C(=O)NCC#N)C(F)(F)F)cc2)n1 CHEMBL382038 IC50 2.6 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC1CCCN(S(=O)(=O)c2cccc[n+]2[O-])CC1=O CHEMBL448605 IC50 2.6 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)nc2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL600793 IC50 2.6 nM
CC(C)C[C@H](NC(=O)c1ccc(-c2csc(N3CCN(C)CC3)n2)cc1)C(=O)N1C[C@@H](C=C(Br)Br)C2OCC(=O)C21 CHEMBL4114675 Ki 2.6 nM
CCCC[C@@H](C=O)NC(=O)O[C@@H](C)CC1CCCCC1 CHEMBL116402 IC50 2.7 nM
CC[C@@H](CNc1ccc(OC)cc1)NC(=O)C1(Nc2cccc(-c3ccccc3)c2)CCCCC1 CHEMBL264314 IC50 2.7 nM
CC(C)=C[C@@H]1CN(C(=O)[C@H](CC(C)C)NC(=O)c2ccc(-c3nc(N4CCN(C)CC4)sc3F)cc2)[C@@H]2C(=O)CO[C@H]12 CHEMBL3661027 Ki 2.7 nM
CC(C)=C[C@@H]1CN(C(=O)[C@H](CC(C)C)NC(=O)c2ccc(-c3nc(N4CCN(C)CC4)sc3F)cc2)C2C(=O)COC21 CHEMBL4114767 Ki 2.7 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)N(C(=O)c2cc3ccccc3s2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL202685 IC50 2.8 nM
C[C@@H](C#N)NC(=O)[C@@H]1C[C@@H](F)CC[C@H]1c1nc(C2(C(F)(F)F)CC2)sc1-c1ccc(N2CCS(=O)(=O)CC2)cc1 CHEMBL3586467 IP 2.8 nM
CCCC[C@H](NC(=O)O[C@H](Cc1nnc(-c2ccc(F)cc2)o1)C(C)(C)C)C(=O)C(=O)NCc1cccnc1 CHEMBL189417 pIC50 2.818 nM
CCCC[C@H](NC(=O)O[C@@H]1CN(C(=O)c2cc3ccccc3s2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL1086660 pIC50 2.818 nM
CCCC[C@@H](C=O)NC(=O)OC(C)(C)Cc1ccc(OC)cc1 CHEMBL264458 IC50 2.9 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC1CN(C(=O)c2ccccc2)CC1=O CHEMBL449314 IC50 2.9 nM
CC(C)C[C@H](NC(=O)c1ccc(-c2noc(-c3cccs3)n2)cc1)C(=O)NCC#N CHEMBL1651359 Ki 2.9 nM
O=C(N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)CNc1ccc(N2CCCCC2)cc1)OCc1ccccc1 CHEMBL169448 Ki 3.0 nM
CSCC[C@@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)CNc1ccc(N2CCCCC2)cc1 CHEMBL172456 Ki 3.0 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)NCCNc1ccc(OCC2CCCC2)cc1 CHEMBL61382 IC50 3.0 nM
CC(C)C[C@@H](C(=O)NCC#N)c1cccc(-c2ccc(N3CCNCC3)cc2)c1 CHEMBL184514 IC50 3.0 nM
CC(C)CC(C(=O)NC1(C#N)CC1)c1cccc(-c2ccc(N3CCNCC3)cc2)c1 CHEMBL331506 IC50 3.0 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)OCC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL196896 IC50 3.0 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)N(C(=O)Cc2ccccc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL204284 IC50 3.0 nM
CC(C)C[C@@H](C(=O)NCC#N)c1cccc(-c2cccc(-c3csc(N4CCC(N(C)C)C4)n3)c2)c1 CHEMBL213244 Ki 3.0 nM
CC(C)(C)Cn1c(COc2ccncc2)cc2cnc(C#N)nc21 CHEMBL249758 IC50 3.0 nM
N#Cc1nc(CCCNc2ccccn2)cc(-c2cccc(C(F)(F)F)c2)n1 CHEMBL1270063 IC50 3.0 nM
CC(C)(NCCCc1cc(-c2cccc(C(F)(F)F)c2)nc(C#N)n1)C(N)=O CHEMBL1270269 IC50 3.0 nM
CC(C)[C@H](N[C@@H](c1ccc(-c2ccc(C3(C(N)=O)CC3)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccc(C#N)cc1F CHEMBL1288531 IC50 3.0 nM
N#CC(NC(=O)[C@@H]1CCCC[C@H]1C(=O)N1CCN(c2ccc(F)cc2)CC1)c1ccccc1 CHEMBL2164669 IC50 3.0 nM
Cc1cccc2c3c([nH]c12)CCN(C(=O)[C@@H]1CCCC[C@H]1C(=O)NC1(C#N)CC1)C3 CHEMBL2163583 IC50 3.0 nM
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2C(=O)N2CCc3[nH]c4ccc(Cl)cc4c3C2)CC1 CHEMBL2164687 IC50 3.0 nM
Cn1c2c(c3c(F)c(F)ccc31)CN(C(=O)[C@@H]1CCCC[C@H]1C(=O)NC1(C#N)CC1)CC2 CHEMBL2164686 IC50 3.0 nM
COc1cc(N2CCN(C(=O)[C@@H]3CCCC[C@H]3C(=O)NC3(C#N)CC3)[C@H](C)C2)ccc1C1CC1 CHEMBL2172003 IC50 3.0 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CCCC2)CC1)C(=O)NC1(C#N)CC1 CHEMBL3640708 Ki 3.0 nM
CC(C)N1CCN(CC#Cc2ccc(CN(CC(C)(C)C)c3ccnc(C#N)n3)cc2)CC1 CHEMBL4078089 IC50 3.0 nM
CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(C)=O)C(=O)NNC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C)C(=O)N[C@H](CCCNC(=N)N)C(N)=O CHEMBL4238973 Ki 3.0 nM
CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(C)=O)C(=O)NNC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C)C(=O)N[C@H](CCCNC(=N)N)C(N)=O CHEMBL4292287 Ki 3.0 nM
CCCC[C@H](NC(=O)O[C@@H]1CN(C(=O)Cc2ccccc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL1087285 pIC50 3.02 nM
CCCC[C@@H](C=O)NC(=O)OC(C)(C)Cc1ccccc1Cl CHEMBL324986 IC50 3.1 nM
CCCC[C@H](NC(=O)O[C@H](Cn1cnc2cc(Cl)c(Cl)cc21)C(C)(C)C)C(=O)CNS(=O)(=O)c1ccccn1 CHEMBL232713 IC50 3.2 nM
CC(C)(C)CNc1nc(C#N)ncc1C#CCN1CCc2ccccc2C1 CHEMBL261511 IC50 3.2 nM
CC(C)[C@@H]1CN(C(=O)[C@@H](NC(=O)c2ccc(N3CCN(C)CC3)cc2)C(C)(C)C)[C@@H]2C(=O)CO[C@@H]21 CHEMBL3640085 Ki 3.2 nM
CCC[C@H](NC(=O)C1(NC(=O)c2ccc(OC(F)(F)F)cc2)CCCCC1)C(=O)c1nnc(OC)o1 CHEMBL379622 Ki app 3.3 nM
CC[C@H](NC(=O)OCc1ccccc1)C(=O)NNC(=O)NNC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL129773 Ki app 3.4 nM
CCCC[C@H](NC(=O)OCC1(CC)CCC1)C(=O)C(=O)Nc1ccn(C)n1 CHEMBL185090 IC50 3.4 nM
N#Cc1ncc2cc(Cc3ccc(N4CCOCC4)cc3)n(C3CCCCC3)c2n1 CHEMBL249564 IC50 3.4 nM
CC(C)C[C@@H](CN1CC(=O)C(NC(=O)[C@H](CC(C)C)NC(=O)OCc2ccncc2)C1)NC(=O)OCc1ccccc1 CHEMBL119285 Ki 3.5 nM
CC(C)C[C@H](NC(=O)c1ccc(C(C)(C)C)cc1)C(=O)N1NC[C@@H]2[C@H]1C(=O)CN2C(=O)c1ccccc1 CHEMBL607122 Ki 3.5 nM
N#Cc1nc(Nc2ccccc2OCCCn2ccnc2)c2ncn(C3CCCC3)c2n1 CHEMBL188865 IC50 3.5 nM
CC(C)CC(C(=O)NCC#N)c1cccc(-c2ccc(-c3csc(N4CCNCC4)n3)cc2)c1 CHEMBL211737 Ki 3.5 nM
CC(C)CC(C(=O)NCC(=O)CNS(=O)(=O)c1ccccn1)c1cccc(-c2ccccc2)c1 CHEMBL2316589 Ki(app) 3.5 nM
CC(C)CC(CN1CC(=O)C(NC(=O)C(CC(C)C)NC(=O)OCc2ccncc2)C1)NC(=O)OCc1ccccc1 CHEMBL2316587 Ki(app) 3.5 nM
CC(C)(C)CN(Cc1ccc(C#CCN2CCC(N3CCCCC3)CC2)cc1)c1ccnc(C#N)n1 CHEMBL261700 IC50 3.6 nM
CSc1ccc(-c2ccccc2C2CCC(F)CC2C(=O)NCC#N)cc1 CHEMBL371954 IC50 3.7 nM
CC(C)(C)CNc1nc(C#N)ncc1C#CCN1CCN(S(=O)(=O)CCCCl)CC1 CHEMBL429147 IC50 3.7 nM
CC[C@@H](CNc1ccc(OC)cc1)NC(=O)[C@H](CC(C)C)Nc1cccc(-c2ccccc2)c1 CHEMBL203117 IC50 3.8 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)N(C(=O)NCc2ccccc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL382990 IC50 3.8 nM
CCCC[C@H](NC(=O)O[C@H](Cn1ccc(-c2ccncc2)n1)C(C)(C)C)C(=O)CNS(=O)(=O)c1ccccn1 CHEMBL393354 IC50 3.8 nM
CN1CCN(CC#Cc2ccc(CN(CC(C)(C)C)c3ccnc(C#N)n3)cc2)CC1 CHEMBL261516 IC50 3.8 nM
CCCC[C@H](NC(=O)O[C@@H]1CN(C(=O)NCc2ccccc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL1084140 pIC50 3.802 nM
CCC[C@@H](CNc1ccc(OC)cc1)NC(=O)C1(Nc2cccc(-c3ccccc3)c2)CCCCC1 CHEMBL204006 IC50 3.9 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC1CN(C(=O)OC(C)(C)C)CC1=O CHEMBL452219 IC50 3.9 nM
CC(C)[C@@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)CNc1ccc(N2CCCCC2)cc1 CHEMBL171403 Ki 4.0 nM
CCC(C)[C@H](NC(=O)c1cccc(CN)c1)C(=O)N[C@@H](CCc1ccccc1)C(=O)CO CHEMBL98540 Ki 4.0 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)NCCNc1ccc(OCc2ccccc2)cc1 CHEMBL60835 IC50 4.0 nM
CCCC[C@@H](C=O)NC(=O)OC(CC)CC CHEMBL325976 IC50 4.0 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@@H]1CC[C@H](C)N(S(=O)(=O)c2ccccn2)CC1=O CHEMBL202991 Ki app 4.0 nM
CCCC[C@H](NC(=O)O[C@H](Cn1ccc(-c2ccc(C(F)(F)F)cc2)n1)C(C)(C)C)C(=O)CNS(=O)(=O)c1ccccn1 CHEMBL203463 IC50 4.0 nM
CSc1ccc(-c2c[nH]c(=O)cc2C2CCC(F)(F)CC2C(=O)NCC#N)cc1 CHEMBL395697 IC50 4.0 nM
CC(C)(C)Cn1c(CN2C(=O)OC(C)(C)C2=O)cc2cnc(C#N)nc21 CHEMBL249759 IC50 4.0 nM
CC(C)(C)Cn1c(Cn2cnc(Cl)c2Cl)cc2cnc(C#N)nc21 CHEMBL250165 IC50 4.0 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC(C)(C)C#N CHEMBL428417 IC50 4.0 nM
CC(C)C(Nc1cccc(C#N)c1)C(=O)N1CCCCN1C#N CHEMBL502439 IC50 4.0 nM
N#Cc1nc(CCCN2CCCCC2)cc(-c2cccc(C(F)(F)F)c2)n1 CHEMBL1084400 IC50 4.0 nM
CCC(CC)NCCCc1cc(-c2cccc(C(F)(F)F)c2)nc(C#N)n1 CHEMBL1084401 IC50 4.0 nM
CCCc1cc(-c2cc(C(=O)N(C)CCN(C)C)cc(C(F)(F)F)c2)nc(C#N)n1 CHEMBL1271070 IC50 4.0 nM
N#Cc1nc(CCCNC2(C(N)=O)CCC2)cc(-c2cccc(C(F)(F)F)c2)n1 CHEMBL1270367 IC50 4.0 nM
CSc1cccc2c3c([nH]c12)CCN(C(=O)[C@@H]1CCCC[C@H]1C(=O)NC1(C#N)CC1)C3 CHEMBL2163588 IC50 4.0 nM
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2C(=O)N2CCc3[nH]c4c(Br)cccc4c3C2)CC1 CHEMBL2163584 IC50 4.0 nM
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2C(=O)N2CCc3[nH]c4cc(F)ccc4c3C2)CC1 CHEMBL2164684 IC50 4.0 nM
COc1ccc(N2CCN(C(=O)[C@@H]3CCCC[C@H]3C(=O)NC3(C#N)CC3)[C@H](C)C2)cc1OC CHEMBL2172005 IC50 4.0 nM
CC(C)C[C@@H](NC(=O)N1CCOCC1)C(=O)N[C@@H](/C=C/S(=O)(=O)c1ccccc1)CCc1ccccc1 CHEMBL222649 IC50 4.0 nM
CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(=O)O)C(=O)NCCCCN=C(N)N CHEMBL374508 IC50 4.0 nM
C#C[C@@H]1CN(C(=O)[C@H](CC(C)C)NC(=O)c2ccc(-c3csc(N4CCN(C)CC4)n3)c(F)c2)[C@@H]2C(=O)CO[C@H]12 CHEMBL3661026 Ki 4.0 nM
C#C[C@@H]1CN(C(=O)[C@H](CC(C)C)NC(=O)c2ccc(-c3csc(N4CCN(C)CC4)n3)c(F)c2)C2C(=O)COC21 CHEMBL4112360 Ki 4.0 nM
CSc1ccc(SC[C@@H]2CCCC[C@H]2C(=O)NCC#N)cc1 CHEMBL201957 IC50 4.2 nM
CC(=O)N1CC(=O)C(NC(=O)[C@H](CC(C)(C)F)N[C@@H](c2ccc(-c3ccc(S(C)(=O)=O)cc3)cc2)C(F)(F)F)C1 CHEMBL481743 IC50 4.2 nM
CCCC[C@H](NC(=O)O[C@@H]1CN(C(=O)Nc2ccccc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL1085680 pIC50 4.266 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)N(C(=O)Nc2ccccc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL206482 IC50 4.3 nM
COC(=O)N1CC(=O)C(NC(=O)[C@H](CC(C)(C)F)N[C@@H](c2ccc(-c3ccc(S(C)(=O)=O)cc3)cc2)C(F)(F)F)C1 CHEMBL480922 IC50 4.3 nM
CC[C@@H]1CN(C(=O)[C@@H](NC(=O)c2ccc(N3CCN(C)CC3)cc2)C(C)(C)C)[C@@H]2C(=O)CO[C@H]12 CHEMBL3640084 Ki 4.4 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@@H]1C[C@H](C)CN(S(=O)(=O)c2ccccn2)CC1=O CHEMBL440574 Ki app 4.5 nM
CC[C@@H](CNc1ccc(OCC(=O)O)cc1)NC(=O)[C@H](CC(C)C)Nc1cccc(-c2ccccc2)c1 CHEMBL536741 IC50 4.5 nM
N#CC1(NC(=O)C2(NC(=O)N3CCC4(CCCC4)CC3)CCCCC2)CC1 CHEMBL3640713 Ki 4.5 nM
CCCC[C@@H](C=O)NC(=O)OC(C)(C)Cc1ccc(Cl)cc1 CHEMBL117149 IC50 4.6 nM
CC(C)CC(NC(c1ccc(-c2ccc(N3CCNCC3)cc2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL195505 IC50 4.6 nM
CCCC[C@@H](C=O)NC(=O)OC(C)(C(C)C)C(C)C CHEMBL117304 IC50 4.7 nM
CC(C)C[C@H](NC(=O)c1cc2cc(OCCN3CCOCC3)ccc2o1)C(=O)N[C@@H]1CCCN(C(=O)Cc2cccc(-c3ccccn3)c2)CC1=O CHEMBL31218 Ki 4.7 nM
CCN(CC)Cc1ccc(Cc2cc3cnc(C#N)nc3n2C2CCCCC2)cc1 CHEMBL430017 IC50 4.7 nM
C[C@@H]1CC[C@H](NC(=O)[C@H](CC(C)(C)C)NC(=O)c2ccco2)C(=O)CN1S(=O)(=O)c1ccccn1 CHEMBL1807650 IC50 4.7 nM
CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1cc2ccccc2cn1 CHEMBL351111 IC50 4.8 nM
CC[C@@H](CNc1ccc(OCC(=O)O)cc1)NC(=O)C1(Nc2cccc(-c3ccccc3)c2)CCCCC1 CHEMBL557986 IC50 4.8 nM
CC[C@@H](CNc1ccc(OCC(=O)OC(C)(C)C)cc1)NC(=O)C1(Nc2cccc(-c3ccccc3)c2)CCCCC1 CHEMBL383551 IC50 4.8 nM
CC(C)C[C@@H](C(=O)NCC#N)c1cccc(-c2cccc(-c3csc(CN4CCNCC4)n3)c2)c1 CHEMBL213194 Ki 4.8 nM
CC(C)(C)CN(Cc1ccc(Cn2cncn2)cc1)c1ccnc(C#N)n1 CHEMBL258640 IC50 4.8 nM
CC[C@@H](CNc1ccc(OCC(=O)O)cc1)NC(=O)C1(Nc2cccc(-c3ccccc3)c2)CCCCC1 CHEMBL1083675 IC50 4.8 nM
CN1CCN(c2nc(-c3ccc(C(=O)NC4(C(=O)N[C@@H]5C(=O)N[C@@H]5Oc5ccccc5)CCCCC4)cc3)cs2)CC1 CHEMBL367800 Ki 4.8 nM
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H]1C(=O)N2CCO[C@@H]12)OCc1ccccc1 CHEMBL115734 IC50 5.0 nM
CC(C)C[C@@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)CNc1ccc(N2CCCCC2)cc1 CHEMBL354439 Ki 5.0 nM
N#CN1CC(CNC(=O)C2CCCCC2)C1 CHEMBL8796 IC50 5.0 nM
O=C(NC(Cc1ccccc1)C(=O)NC1C(=O)N2CCO[C@@H]12)OCc1ccccc1 CHEMBL332025 IC50 5.0 nM
N#CCNC(=O)C1(NC(c2ccc(-c3ccc(N4CCNCC4)cc3)cc2)C(F)(F)F)CCCCC1 CHEMBL194914 IC50 5.0 nM
CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@H]2C(=O)NCC#N)cc1 CHEMBL201415 IC50 5.0 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)N(C(=O)Oc2ccc(-c3ccccc3)cc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL205517 IC50 5.0 nM
CSc1ccc(-c2c[n+]([O-])ccc2C2CCC(F)(F)CC2C(=O)NCC#N)cc1 CHEMBL247783 IC50 5.0 nM
CSC[C@H](N[C@@H](c1ccc(Br)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL249698 IC50 5.0 nM
CC(C)(C)Cn1c(Cn2ccnn2)cc2cnc(C#N)nc21 CHEMBL249757 IC50 5.0 nM
N#CCNC(=O)C1(N[C@@H](c2ccc(-c3ccc(N4CCNCC4)cc3)cc2)C(F)(F)F)CCCCC1 CHEMBL479755 IC50 5.0 nM
N#Cc1nc(CCCNC2(C(N)=O)CCOCC2)cc(-c2cccc(C(F)(F)F)c2)n1 CHEMBL1270461 IC50 5.0 nM
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2C(=O)N2CCc3[nH]c4c(C(F)(F)F)cccc4c3C2)CC1 CHEMBL2163586 IC50 5.0 nM
COc1ccc(N2CCN(C(=O)[C@@H]3CCCC[C@H]3C(=O)NC3(C#N)CC3)[C@H](C)C2)nc1OC CHEMBL2172002 IC50 5.0 nM
CCCC[C@H](NC(=O)O[C@@H]1CN(C(=O)Oc2ccc(-c3ccccc3)cc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL1077003 pIC50 5.012 nM
CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1ccon1 CHEMBL356378 IC50 5.1 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@@H](C#N)Cc1ccccc1 CHEMBL252382 IC50 5.1 nM
CCC[C@H](NC(=O)C1(NC(=O)c2ccc(OC(F)(F)F)cc2)CCCCC1)C(=O)c1nnc(-c2cccs2)o1 CHEMBL209114 Ki app 5.2 nM
CS(=O)(=O)C[C@H](N[C@@H](c1ccc(-c2ccc(F)cc2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL248889 IC50 5.3 nM
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2c2nn(CC3CC3)cc2-c2ccc(N3CCS(=O)(=O)CC3)cc2)CC1 CHEMBL5187747 IC50 5.3 nM
CCCC[C@@H](C=O)NC(=O)OC(C)(C)Cc1cccc(OC)c1 CHEMBL117303 IC50 5.4 nM
CC(C)C[C@H](NC(=O)c1ccc(N(C)C)cc1)C(=O)N1CC[C@@H]2[C@H]1C(=O)CN2C(=O)c1ccccc1 CHEMBL607123 Ki 5.5 nM
CCCC[C@H](NC(=O)OCC1(COc2nc(-c3ccccc3)cs2)CCC1)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL187918 IC50 5.5 nM
CCCC[C@H](NC(=O)O[C@H](Cn1ccc(-c2cccnc2)n1)C(C)(C)C)C(=O)CNS(=O)(=O)c1ccccn1 CHEMBL232520 IC50 5.5 nM
CCCC[C@@H](CNc1ccc(OC)cc1)NC(=O)C1(Nc2cccc(-c3ccccc3)c2)CCCCC1 CHEMBL203832 IC50 5.6 nM
CC(=O)O[C@@H]1NC(=O)[C@H]1NC(=O)C1(NC(=O)OCc2ccccc2)CCCCC1 CHEMBL62655 Ki 5.7 nM
CCCC[C@H](NC(=O)OC1C2(C)CCC(C2)C1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL193582 IC50 5.7 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC1CCN(S(=O)(=O)c2ccccn2)CC1=O CHEMBL446544 IC50 5.7 nM
CC[C@H](C)[C@H](NC(=O)NNC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)OC)C(C)C CHEMBL2028920 Ki 5.75 nM
CCCC[C@H](NC(=O)O[C@H](Cn1cnc(-c2ccc(C(F)(F)F)cc2)c1)C(C)(C)C)C(=O)C(=O)Nc1nccs1 CHEMBL187864 pIC50 5.754 nM
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2c2nc(C3CC(F)(F)C3)sc2-c2ccc(N3CCS(=O)(=O)CC3)cc2)CC1 CHEMBL3586464 IP 5.8 nM
COc1ccc(NCCNC(=O)[C@H](CC(C)C)NC(=O)c2ccc(OCc3ccccc3)cc2)cc1 CHEMBL77665 IC50 6.0 nM
COc1ccc(NCCNC(=O)[C@H](CC(C)C)NC(=O)c2ncn(-c3ccccc3Cl)n2)cc1 CHEMBL74142 IC50 6.0 nM
O=C(N[C@@H](Cc1cccc(F)c1)C(=O)N[C@@H]1C(=O)N2CCS(=O)(=O)[C@@H]12)OCc1ccccc1 CHEMBL116041 IC50 6.0 nM
CC(C)C[C@@H](C(=O)NCC#N)c1cccc(-c2ccc(N3CCN(C)CC3)cc2)c1 CHEMBL2111806 IC50 6.0 nM
CC(C)CC(C(=O)NCC#N)c1cccc(-c2ccc(N3CCN(CC(C)(C)O)CC3)cc2)c1 CHEMBL122879 IC50 6.0 nM
CN1CCN(CCn2cnc3c(NC4CCCCC4)nc(C#N)nc32)CC1 CHEMBL363847 IC50 6.0 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2cc(F)cc(F)c2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL208481 IC50 6.0 nM
CSCC[C@H](NC(=O)[C@H](CC(C)C)N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(N)=O CHEMBL401176 Km 6.0 nM
CC(C)(C)Cn1c(Cn2ccnc2)cc2cnc(C#N)nc21 CHEMBL248539 IC50 6.0 nM
Cc1cccc(NC(C(=O)N2CCCCN2C#N)C(C)C)c1 CHEMBL493038 IC50 6.0 nM
N#Cc1ncc2cc(Cc3ccc(Cl)cc3)n(CC3CCCCC3)c2n1 CHEMBL492633 IC50 6.0 nM
CC(C)CNc1nc(C#N)nc(N2CCNCC2)c1N CHEMBL474484 IC50 6.0 nM
CNCCCc1cc(-c2cccc(C(F)(F)F)c2)nc(C#N)n1 CHEMBL1271380 IC50 6.0 nM
C[C@@H]1CN(c2ccccc2)CCN1C(=O)[C@@H]1CCCC[C@H]1C(=O)NCC#N CHEMBL2172006 IC50 6.0 nM
COc1ccc(N2CCN(C(=O)[C@@H]3CCCC[C@H]3C(=O)NCC#N)CC2)cc1OC CHEMBL2171988 IC50 6.0 nM
COc1ccc(N2CCN(C(=O)[C@@H]3CCCC[C@H]3C(=O)NCC#N)CC2)cc1 CHEMBL2171986 IC50 6.0 nM
CCCC[C@H](NC(=O)OCC1(CC)CCC1)C(=O)C(=O)Nc1cc(-c2ccccc2)[nH]n1 CHEMBL183632 IC50 6.2 nM
CCCC[C@H](NC(=O)OC(C1CCCC1)C1CCCC1)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL355138 IC50 6.3 nM
CC[C@@H](CNc1ccc(OCC(=O)OC(C)(C)C)cc1)NC(=O)[C@H](CC(C)C)Nc1cccc(-c2ccccc2)c1 CHEMBL202703 IC50 6.4 nM
CCCC[C@H](NC(=O)O[C@H](Cn1cnc(-c2ccc(C(F)(F)F)cc2)c1)C(C)(C)C)C(=O)CNS(=O)(=O)c1ccccn1 CHEMBL233706 IC50 6.4 nM
CC(=O)N1CCN(CC#Cc2ccc(CN(CC(C)(C)C)c3ccnc(C#N)n3)cc2)CC1 CHEMBL410520 IC50 6.4 nM
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H]1C(=O)N[C@H]1S(=O)(=O)c1ccccc1)OCc1ccccc1 CHEMBL287630 IC50 6.5 nM
CCCC[C@@H](C=O)NC(=O)O[C@H](Cc1ccccc1)CC(C)C CHEMBL114904 IC50 6.5 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)N(C(=O)NCCc2ccccc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL206740 IC50 6.6 nM
CCCC[C@H](NC(=O)O[C@@H]1CN(C(=O)NCCc2ccccc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL1087697 pIC50 6.607 nM
CC(C)C[C@H](N[C@@H](c1ccccc1)C(F)(F)F)C(=O)NCC#N CHEMBL204276 IC50 6.7 nM
CC(C)C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)NNC(=O)N[C@@H](C)C(=O)NCC(N)=O)C(C)C CHEMBL2028908 Ki 6.76 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)N(C(=O)c2ccc(-c3ccccc3)cc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL380300 IC50 6.9 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC1CCN(c2ccccc2S(C)(=O)=O)CC1=O CHEMBL500567 IC50 6.9 nM
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2c2nn(CC(F)(F)F)cc2-c2ccc(N3CCS(=O)(=O)CC3)cc2)CC1 CHEMBL5203247 IC50 6.9 nM
CCCC[C@H](NC(=O)O[C@@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL1077001 pIC50 6.918 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2s1)C(=O)N[C@H]1COCC1=O CHEMBL61408 Ki 7.0 nM
CN1CCN(CCCOc2ccccc2Nc2nc(C#N)nc3c2ncn3C2CCCC2)CC1 CHEMBL188139 IC50 7.0 nM
N#CCNC(=O)[C@@H]1CCCC[C@H]1C(=O)N1CCN(c2ccccc2)CC1 CHEMBL2164676 IC50 7.0 nM
CSc1ccc(-c2ccccc2[C@H]2CCC(F)(F)C[C@@H]2C(=O)NCC#N)cc1 CHEMBL202103 IC50 7.1 nM
CN1CCN(c2ccc(CC#Cc3cnc(C#N)nc3NCC(C)(C)C)cc2)CC1 CHEMBL259939 IC50 7.1 nM
COc1ccc(S(=O)(=O)N2CCN(CC#Cc3cnc(C#N)nc3NCC(C)(C)C)CC2)cc1 CHEMBL261455 IC50 7.1 nM
CCCC[C@H](NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL197509 IC50 7.2 nM
CC(C)(C)CNc1nc(C#N)ncc1C#CCn1cnc(Cl)c1Cl CHEMBL408562 IC50 7.2 nM
CC(C)CC(NC(=O)c1cccc(-c2ccc(S(C)(=O)=O)cc2)c1)C(=O)N(C)N(C)C#N CHEMBL4454648 Ki 7.21 nM
CC(C)(C)CN(Cc1ccc(C#CCN2CCCCC2)cc1)c1ccnc(C#N)n1 CHEMBL408974 IC50 7.3 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC1CN(C(N)=O)CC1=O CHEMBL481744 IC50 7.3 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC1CN(C(=O)Nc2ccccc2)CC1=O CHEMBL501877 IC50 7.3 nM
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H]1C(=O)N2CCS(=O)(=O)[C@H]12)OCc1ccccc1 CHEMBL323637 IC50 7.5 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@@H](C)C(=O)CNS(=O)(=O)c1ccccn1 CHEMBL31545 Ki 7.5 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CC1)CCN(C1CC1)CC2)C(=O)NC1(C#N)CC1 CHEMBL3640714 Ki 7.5 nM
O=C(N[C@@H](CC1CCCCC1)C(=O)N[C@@H]1C(=O)N2CCS(=O)(=O)[C@@H]12)OCc1ccccc1 CHEMBL114410 IC50 7.6 nM
CCCC[C@@H](C=O)NC(=O)OC(C)(C)Cc1cccc(-c2ccsc2)c1 CHEMBL326494 IC50 7.6 nM
C[C@@H](NC(=O)C(=O)[C@H](CCCCNC(=O)N1CCOCC1)NC(=O)OCC1(Cc2ccncc2)CCC1)c1ccccc1 CHEMBL362878 IC50 7.6 nM
CCCC[C@H](NC(=O)O[C@H](Cn1cc(-c2ccc(C(F)(F)F)cc2)cn1)C(C)(C)C)C(=O)CNS(=O)(=O)c1ccccn1 CHEMBL393673 IC50 7.6 nM
CCCC[C@H](NC(=O)OCC1(COc2nc(C(F)(F)F)cs2)CCC1)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL361507 IC50 7.9 nM
CCC[C@H](NC(=O)C1(NC(=O)c2ccc(OC(F)(F)F)cc2)CCCCC1)C(=O)c1nnc(CC)o1 CHEMBL405602 Ki app 7.9 nM
N#CN1CC[C@@H](NS(=O)(=O)c2cccc(Br)c2)C1 CHEMBL1672425 pIC50 7.943 nM
O=C(N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCc1ccccc1)CNc1ccc(N2CCCCC2)cc1)OCc1ccccc1 CHEMBL169560 Ki 8.0 nM
CC(C)CC(C(=O)NCC#N)c1cccc(-c2ccc(N3CCN(C)CC3)cc2)c1 CHEMBL123227 IC50 8.0 nM
CC(C)C[C@@H](C(=O)NCC#N)c1cccc(-c2ccc3[nH]ccc3c2)c1 CHEMBL2448126 IC50 8.0 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2s1)C(=O)NC1CCOCC1=O CHEMBL305084 Ki 8.0 nM
CSc1ccc(-c2c(C3CCC(F)(F)CC3C(=O)NCC#N)cc[nH]c2=O)cc1 CHEMBL245381 IC50 8.0 nM
N#Cc1nc(CCCO)cc(-c2cccc(C(F)(F)F)c2)n1 CHEMBL1271273 IC50 8.0 nM
N#Cc1nc(CCCNCC(N)=O)cc(-c2cccc(C(F)(F)F)c2)n1 CHEMBL1270268 IC50 8.0 nM
Cc1nn(C)c2cc(N3CCN(C(=O)[C@@H]4CCCC[C@H]4C(=O)NC4(C#N)CC4)[C@H](C)C3)ccc12 CHEMBL2172000 IC50 8.0 nM
COc1cccc(N2CCN(C(=O)[C@@H]3CCCC[C@H]3C(=O)NCC#N)CC2)c1 CHEMBL2171987 IC50 8.0 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)N(S(=O)(=O)c2ccccc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL439517 IC50 8.3 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC1CCN(c2ccccc2)CC1=O CHEMBL500545 IC50 8.3 nM
CCCC[C@H](NC(=O)O[C@@H]1CN(S(=O)(=O)c2ccccc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL1087284 pIC50 8.318 nM
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H]1C(=O)N[C@H]1Sc1ccccc1)OCc1ccccc1 CHEMBL31788 IC50 8.4 nM
CC[C@H](C)[C@H](NC(=O)NNC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)OC)C(C)C CHEMBL2028912 Ki 8.42 nM
CCCC[C@H](NC(=O)OCC1(Cc2ccccc2)CCC1)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL366268 IC50 8.5 nM
CC(C)C[C@H](NC(=O)C1CCNCC1)C(=O)N[C@@H](CCc1ccccc1)C(=O)c1nc2cc(C(C)(C)C)ccc2o1 CHEMBL257692 Ki 8.5 nM
CC(C)(C)CN(Cc1ccc(C#CCn2cncn2)cc1)c1ccnc(C#N)n1 CHEMBL263409 IC50 8.6 nM
CC(C)(C)CNc1nc(C#N)ncc1C#CCOc1cccnc1 CHEMBL261673 IC50 8.6 nM
CCC(NC(=O)c1ccc(OCc2ccccn2)c(C(F)(F)F)c1Cl)C(=O)C(N)=O CHEMBL1289536 IC50 8.7 nM
CC(C)C[C@H](NC(=O)c1ccc(N2CCN(C)CC2)cc1)C(=O)N1CC[C@H]2OCC(=O)[C@H]21 CHEMBL3640071 Ki 8.7 nM
CC(=O)O[C@@H]1NC(=O)[C@H]1NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)OCc1ccccc1 CHEMBL64098 Ki 8.8 nM
CC[C@@H](CC1CCCCC1)OC(=O)NC1CCN(C#N)C1 CHEMBL369080 IC50 8.9 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)N(C(=O)c2ccno2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL383687 IC50 8.9 nM
CCCC[C@H](NC(=O)O[C@@H]1CN(C(=O)c2ccno2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL1089046 pIC50 8.913 nM
COc1ccc(NCCNC(=O)[C@H](CC(C)C)NC(=O)c2ncn(-c3cccc(Cl)c3Cl)n2)cc1 CHEMBL80508 IC50 9.0 nM
C[C@@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)CNc1ccc(N2CCCCC2)cc1 CHEMBL353633 Ki 9.0 nM
COc1ccc(NCCNC(=O)[C@H](CC(C)C)NC(=O)c2ccc(OC)cc2)cc1 CHEMBL59605 IC50 9.0 nM
CC(C)CC(C(=O)NCC#N)c1cccc(-c2ccc(N3CCNCC3)cc2)c1 CHEMBL122149 IC50 9.0 nM
CC(C)C[C@H](NC(=O)CN1CCN(c2ccncc2)CC1)C(=O)N[C@H](C#N)COCc1ccccc1 CHEMBL207560 IC50 9.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](C#N)COCc1ccccc1 CHEMBL206006 IC50 9.0 nM
N#Cc1ncc(C(=O)NCCc2ccccc2)c(OCC2CCCCC2)n1 CHEMBL463180 IC50 9.0 nM
CCOC(=O)N1CCC(NC(=O)[C@H](CC(C)(C)F)N[C@@H](c2ccc(-c3ccc(S(C)(=O)=O)cc3)cc2)C(F)(F)F)C(=O)C1 CHEMBL499380 IC50 9.0 nM
CC(=O)N1CCN(c2nc(C#N)nc(NCC(C)C)c2N)CC1 CHEMBL514805 IC50 9.0 nM
CCCc1cc(-c2cc(C(=O)N(C)Cc3ccccc3)cc(C(F)(F)F)c2)nc(C#N)n1 CHEMBL1271174 IC50 9.0 nM
N#Cc1nc(CCCN2CCOCC2)cc(-c2cccc(C(F)(F)F)c2)n1 CHEMBL1269955 IC50 9.0 nM
N#Cc1nc(CCCN2CCC(O)CC2)cc(-c2cccc(C(F)(F)F)c2)n1 CHEMBL1270062 IC50 9.0 nM
N#Cc1nc(CCCNCC(=O)O)cc(-c2cccc(C(F)(F)F)c2)n1 CHEMBL1270170 IC50 9.0 nM
C[C@@H]1CC[C@H](NC(=O)[C@H](CC2=CCCC2)NC(=O)c2ccco2)C(=O)CN1S(=O)(=O)c1ccccn1 CHEMBL1807645 IC50 9.0 nM
Cc1nn(C)c2ccc(N3CCN(C(=O)[C@@H]4CCCC[C@H]4C(=O)NC4(C#N)CC4)[C@H](C)C3)cc12 CHEMBL2171999 IC50 9.0 nM
C[C@@H]1CN(c2ccc3c(c2)OCO3)CCN1C(=O)[C@@H]1CCCC[C@H]1C(=O)NC1(C#N)CC1 CHEMBL2172004 IC50 9.0 nM
COc1ccc(N2CCN(C(=O)[C@@H]3CCCC[C@H]3C(=O)NC3(C#N)CC3)CC2)cc1OC CHEMBL2171993 IC50 9.0 nM
N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)NNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)c1ccc(N)cc1)C(=O)N[C@@H](Cc1ccc(O)c([N+](=O)[O-])c1)C(N)=O CHEMBL4287663 Ki 9.0 nM
CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)NCc1cccs1 CHEMBL422686 IC50 9.2 nM
CCCC[C@H](NC(=O)OCC1(CSc2nccc(-c3ccc(Cl)cc3)n2)CCC1)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL365081 IC50 9.5 nM
CC(C)C[C@H](NC(=O)C1CCNCC1)C(=O)N[C@@H](CCc1ccccc1)C(=O)c1nc2ccccc2o1 CHEMBL270792 Ki 9.5 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC1CNCC1=O CHEMBL481814 IC50 9.8 nM