O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H]1C(=O)N[C@@H]1Oc1ccccc1)OCc1ccccc1 CHEMBL30401 IC50 0.0 nM
N#Cc1ncc(C(=O)NCc2ccc(C(F)(F)F)cc2)c(N2CC[C@H](S(=O)(=O)c3ccccc3C(F)(F)F)C2)n1 CHEMBL3651506 IC50 0.029 nM
N#Cc1nc(N2CC[C@H](S(=O)(=O)c3ccc(-n4cccn4)cc3Cl)C2)cc(C(F)(F)F)n1 CHEMBL3651502 IC50 0.052 nM
N#Cc1nc(N2CC[C@H](S(=O)(=O)c3ccc(N4CCN(C5CC5)CC4)cc3Cl)C2)cc(C(F)(F)F)n1 CHEMBL3651503 IC50 0.056 nM
CC(CNC(=O)c1cnc(C#N)nc1N1CC[C@H](S(=O)(=O)c2ccccc2C(F)(F)F)C1)c1ccc(Cl)cc1 CHEMBL3651507 IC50 0.056 nM
N#Cc1ncc(C(=O)NCC(F)(F)F)c(N2CC[C@H](S(=O)(=O)c3ccccc3C(F)(F)F)C2)n1 CHEMBL3651508 IC50 0.061 nM
CC(C)(C)CC(=O)N[C@@H](CS(=O)(=O)N1CCN(c2ccccn2)CC1)C(=O)NC1(C#N)CC1 CHEMBL4777335 Ki 0.09 nM
N#C[C@H](COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cccs1 CHEMBL155560 Kd 0.1 nM
Cc1ccccc1COC[C@@H](C#N)NC(=O)[C@H](CC1CCCCC1)NC(=O)N1CCOCC1 CHEMBL356442 Kd 0.1 nM
C[C@@](NC(=O)c1ccsc1)(c1cn(CC#N)nn1)[C@H]1CC[C@H](C)CC1 CHEMBL2207565 IC50 0.1 nM
C[C@H](C#N)n1cc([C@@](C)(NC(=O)c2ccsc2)[C@H]2CC[C@H](C)CC2)nn1 CHEMBL2207564 IC50 0.1 nM
N#Cc1nc(N2CC[C@H](S(=O)(=O)c3ccc(-n4ccnc4)cc3Cl)C2)cc(C(F)(F)F)n1 CHEMBL3651509 IC50 0.11 nM
N#Cc1ncc(C(=O)NCCc2ccccc2)c(NC2CCCCC2)n1 CHEMBL386506 IC50 0.13 nM
CC(C)(C)OC(=O)NN(C#N)CC(=O)N(Cc1ccccc1)Cc1ccccc1 CHEMBL3342185 Ki 0.13 nM
COCCOc1ccc(S(=O)(=O)[C@H]2CCN(c3cc(C(F)(F)F)nc(C#N)n3)C2)c(Cl)c1 CHEMBL3651505 IC50 0.13 nM
CC(C)C[C@H](NC(=O)c1ccc(-c2noc(-c3cccs3)n2)cc1)C(=O)N(C)N(C)C#N CHEMBL1651361 Ki 0.15 nM
CC(C)(C)N1CCN(c2ccc(S(=O)(=O)[C@H]3CCN(c4cc(C(F)(F)F)nc(C#N)n4)C3)c(Cl)c2)CC1 CHEMBL3651499 IC50 0.15 nM
N#Cc1ncc(C(=O)NCc2ccc(C(F)(F)F)cc2)c(N2CC[C@H](S(=O)(=O)c3cccc(Cl)c3Cl)C2)n1 CHEMBL3651510 IC50 0.155 nM
CC(C)C[C@H](NC(=O)Nc1ccccc1)C(=O)N(C)N(C)C#N CHEMBL1651355 Ki 0.16 nM
CC(C)C[C@H](NC(=O)NCc1ccc(-c2noc(-c3cccs3)n2)cc1)C(=O)N(C)N(C)C#N CHEMBL1651357 Ki 0.16 nM
N#Cc1nc(N2CC[C@H](S(=O)(=O)c3ccccc3C(F)(F)F)C2)cc(C(F)(F)F)n1 CHEMBL3651495 IC50 0.167 nM
Cc1nc(-c2ccc(CNC(=O)N[C@@H](CC(C)C)C(=O)N(C)N(C)C#N)cc2)no1 CHEMBL1651356 Ki 0.17 nM
CN(Cc1ccccc1)C(=O)CN(C#N)NC(=O)OC(C)(C)C CHEMBL3342184 Ki 0.176 nM
Cc1nc(-c2ccc(NC(=O)N[C@@H](CC(C)C)C(=O)N(C)N(C)C#N)cc2)no1 CHEMBL1651349 Ki 0.19 nM
N#CC1(NC(=O)[C@H](CS(=O)(=O)c2ccc(Cl)c(Cl)c2)N[C@@H](c2ccc(F)cc2)C(F)(F)F)CC1 CHEMBL251117 IC50 0.2 nM
N#CC1(NC(=O)[C@H](CS(=O)(=O)c2ccc(Cl)c(Cl)c2)N[C@@H](c2ccccc2)C(F)(F)F)CC1 CHEMBL443319 IC50 0.2 nM
N#CC1(NC(=O)[C@H](CS(=O)(=O)c2cccc(Br)c2)N[C@@H](c2ccccc2)C(F)(F)F)CC1 CHEMBL251719 IC50 0.2 nM
CN(C#N)N(C)C(=O)[C@H](CC1CCCCC1)NC(=O)OCc1ccccc1 CHEMBL1651352 Ki 0.2 nM
CC(C)C[C@H](NC(=O)NCc1ccccc1)C(=O)N(C)N(C)C#N CHEMBL1651354 Ki 0.2 nM
N#CC1(NC(=O)[C@H](CS(=O)(=O)N2CCN(c3ccccn3)CC2)NC(=O)Cc2cccs2)CC1 CHEMBL4777740 Ki 0.2 nM
N#Cc1nc2c(c(N3CC[C@H](S(=O)(=O)c4ccccc4C(F)(F)F)C3)n1)CCC2 CHEMBL3651493 IC50 0.205 nM
CCCC[C@H](NC(=O)O[C@H](Cn1ccc(-c2ccc(C(F)(F)F)cc2)n1)C(C)(C)C)C(=O)C(=O)Nc1ccn[nH]1 CHEMBL234367 IC50 0.21 nM
COc1cccc(CCNC(=O)c2cnc(C#N)nc2NC2CCCCC2)c1 CHEMBL385632 IC50 0.23 nM
N#CC1(NC(=O)[C@H](CS(=O)(=O)N2CCN(c3ccccn3)CC2)Nc2cccnc2)CC1 CHEMBL4761229 Ki 0.25 nM
O=C[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 CHEMBL177914 Ki app 0.26 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649369 IC50 0.296 nM
CC(C)C[C@H](NC(=O)N1CCOCC1)C(=O)N[C@H](C#N)COCc1ccccc1 CHEMBL153813 Kd 0.3 nM
Cc1ccccc1COC[C@@H](C#N)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1CCOCC1 CHEMBL152940 Kd 0.3 nM
CC(C)C[C@H](NC(=O)N1CCOCC1)C(=O)N[C@H](C#N)COCc1ccccc1Cl CHEMBL149523 Kd 0.3 nM
N#CC1(NC(=O)[C@H](CS(=O)(=O)c2ccc(Br)cc2)N[C@@H](c2ccccc2)C(F)(F)F)CC1 CHEMBL250720 IC50 0.3 nM
N#CC1(NC(=O)[C@H](CS(=O)(=O)Cc2cccc(F)c2F)N[C@@H](c2ccc(F)cc2)C(F)(F)F)CC1 CHEMBL400750 IC50 0.3 nM
N#CC1(NC(=O)[C@H](CS(=O)(=O)Cc2cccc(F)c2F)N[C@@H](c2ccccc2)C(F)(F)F)CC1 CHEMBL398553 IC50 0.3 nM
CCCC[C@H](C#N)n1cc([C@@](C)(NC(=O)c2ccsc2)[C@H]2CC[C@H](C)CC2)nn1 CHEMBL2207562 IC50 0.3 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2CCCCC2)CC1 CHEMBL3093935 IC50 0.3 nM
N#CC1(NC(=O)[C@H](CC(F)(F)Cc2ccccc2)NC(=O)N2CCC3(CC2)CC3)CC1 CHEMBL3640716 Ki 0.3 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2(N3CCSCC3)CC2)CC1 CHEMBL3701872 IC50 0.3 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3cccc(Cl)c3)CN2C(=O)C2(N3CCCCC3)CC2)CC1 CHEMBL3701887 IC50 0.3 nM
N#Cc1ncc(C(=O)NCC2(c3ccc(Cl)cc3)CC2)c(N2CC[C@H](S(=O)(=O)c3ccccc3C(F)(F)F)C2)n1 CHEMBL3651511 IC50 0.305 nM
N#Cc1nccc(N2CC[C@H](S(=O)(=O)c3ccccc3C(F)(F)F)C2)n1 CHEMBL3651473 IC50 0.31 nM
CC(C)C[C@H](NC(=O)Nc1ccc(-c2noc(-c3cccs3)n2)cc1)C(=O)N(C)N(C)C#N CHEMBL1651350 Ki 0.32 nM
N#Cc1ncc(C(=O)NCC(F)(F)F)c(N2CC[C@H](S(=O)(=O)c3cccc(Cl)c3Cl)C2)n1 CHEMBL3651541 IC50 0.32 nM
Cc1ncccc1-c1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ncc(Cl)cc4F)CC3)C2)c(Cl)c1 CHEMBL4111061 IC50 0.322 nM
CC(C)[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649389 IC50 0.328 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N(C)N(C)C#N CHEMBL608115 Ki 0.33 nM
N#Cc1nc(N2CC[C@H](S(=O)(=O)c3ccc(F)cc3Cl)C2)cc(C(F)(F)F)n1 CHEMBL3651497 IC50 0.335 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(Cl)cc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649399 IC50 0.34 nM
N#Cc1nc(N2CC[C@H](S(=O)(=O)c3ccc(N4CCN5CCC[C@H]5C4)cc3Cl)C2)cc(C(F)(F)F)n1 CHEMBL3651500 IC50 0.355 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649370 IC50 0.367 nM
Cn1cc(-c2ccc(S(=O)(=O)[C@@H]3C[C@@H](C(=O)NC4(C#N)CC4)N(C(=O)C4(c5ncc(Cl)cc5F)CC4)C3)c(Cl)c2)cn1 CHEMBL4111007 IC50 0.375 nM
CC(C)(C)OC(=O)N1CCC1(C(=O)N1C[C@H](S(=O)(=O)c2ccc(F)cc2Cl)C[C@H]1C(=O)NC1(C#N)CC1)c1ncc(Cl)cc1F CHEMBL3671339 IC50 0.377 nM
Cc1ncccc1-c1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ncc(I)cc4F)CC3)C2)c(Cl)c1 CHEMBL4113661 IC50 0.382 nM
COc1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ncc(Cl)cc4F)CC3)C2)c(Cl)c1 CHEMBL4114586 IC50 0.393 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2(c3ncc(Cl)cc3F)CC2)CC1 CHEMBL4109015 IC50 0.398 nM
N#C[C@H](COCc1ccccc1Cl)NC(=O)[C@H](CC1CCCCC1)NC(=O)N1CCOCC1 CHEMBL150253 Kd 0.4 nM
N#C[C@H](COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)N1CCOCC1 CHEMBL347111 Kd 0.4 nM
N#C[C@H](COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccco1 CHEMBL153018 Kd 0.4 nM
N#CC1(NC(=O)[C@H](CS(=O)(=O)c2ccc(F)cc2)N[C@@H](c2ccc(F)cc2)C(F)(F)F)CC1 CHEMBL251114 IC50 0.4 nM
CC(C)CS(=O)(=O)C[C@H](N[C@@H](c1ccc(F)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL399063 IC50 0.4 nM
N#CC1(NC(=O)[C@H](CS(=O)(=O)CC2CC2)N[C@@H](c2ccc(F)cc2)C(F)(F)F)CC1 CHEMBL251327 IC50 0.4 nM
C[C@@H]1CN(C(=O)[C@@H]2C[C@H](S(=O)(=O)c3ccccc3)C[C@H]2C(=O)NC2(C#N)CC2)C[C@H](C)O1 CHEMBL3093822 IC50 0.4 nM
C[C@H]1CC[C@H]([C@H](NC(=O)c2cccc(-n3ccnc3)c2)C(=O)N2C[C@H](Cl)[C@H]3OCC(=O)[C@H]32)CC1 CHEMBL3648414 Ki 0.4 nM
CC1CCCN(C2(C(=O)N3C[C@H](S(=O)(=O)c4ccccc4Cl)C[C@H]3C(=O)NC3(C#N)CC3)CC2)C1 CHEMBL3701871 IC50 0.4 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(F)cc3Cl)CN2C(=O)C2(N3CCCCC3)CC2)CC1 CHEMBL3701886 IC50 0.4 nM
Cc1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(N4CCCCC4)CC3)C2)cc1 CHEMBL3701888 IC50 0.4 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3cccc(C(F)(F)F)c3)CN2C(=O)C2(N3CCCCC3)CC2)CC1 CHEMBL3701890 IC50 0.4 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649386 IC50 0.403 nM
CN1CCN(c2ccc(S(=O)(=O)[C@H]3CCN(c4cc(C(F)(F)F)nc(C#N)n4)C3)c(Cl)c2)CC1 CHEMBL3651498 IC50 0.415 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2(c3ncc(Br)cc3F)CC2)CC1 CHEMBL4110952 IC50 0.438 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Br)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649377 IC50 0.442 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(Br)cc3Cl)CN2C(=O)C2(c3ncc(Cl)cc3F)CC2)CC1 CHEMBL4114015 IC50 0.474 nM
CC(C)[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649418 IC50 0.478 nM
CN1CCN(c2ccc(CCNC(=O)c3cnc(C#N)nc3NC3CCCCC3)cc2)CC1 CHEMBL219536 IC50 0.48 nM
CC(C)(C)OC(=O)N1CCC1(C(=O)N1C[C@H](S(=O)(=O)c2ccc(F)cc2Cl)C[C@H]1C(=O)NC1(C#N)CC1)c1ncc(Br)cc1F CHEMBL3671340 IC50 0.492 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2(c3ccc(Cl)cn3)CC2)CC1 CHEMBL4115025 IC50 0.492 nM
CC(C)C[C@H](NC(=O)N1CCOCC1)C(=O)N[C@H](C#N)COCc1cccc(Cl)c1 CHEMBL356167 Kd 0.5 nM
N#CC1(NC(=O)[C@H](CS(=O)(=O)Cc2ccc(F)cc2)N[C@@H](c2ccccc2)C(F)(F)F)CC1 CHEMBL400728 IC50 0.5 nM
C[C@@H]1CC[C@H](NC(=O)[C@H](CC2CCCCC2)NC(=O)c2ccco2)C(=O)CN1S(=O)(=O)c1ccccn1 CHEMBL1807647 IC50 0.5 nM
CC1CCC(C[C@H](NC(=O)c2ccco2)C(=O)N[C@H]2CC[C@@H](C)N(S(=O)(=O)c3ccccn3)CC2=O)CC1 CHEMBL1807698 IC50 0.5 nM
N#CC1(n2cc([C@@H](NC(=O)c3ccc(NC(=O)C4CC4)cc3)C3CCCCC3)nn2)CC1 CHEMBL2207591 IC50 0.5 nM
C[C@@H](C#N)n1cc([C@@](C)(NC(=O)c2ccsc2)[C@H]2CC[C@H](C)CC2)nn1 CHEMBL2207563 IC50 0.5 nM
CC1CCN(C(=O)[C@@H]2C[C@H](S(=O)(=O)c3ccccc3)C[C@H]2C(=O)NC2(C#N)CC2)CC1 CHEMBL3093826 IC50 0.5 nM
N#CCNC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)C[C@H]1C(=O)N1CCOCC1 CHEMBL3093941 IC50 0.5 nM
CCCC(F)(F)C[C@H](NC(=O)N1CCC2(CC1)CC2)C(=O)NC1(C#N)CC1 CHEMBL3640728 Ki 0.5 nM
N#Cc1ncc(C(=O)NC2(c3ccc(F)cc3)CC2)c(N2CC[C@H](S(=O)(=O)c3cccc(Cl)c3Cl)C2)n1 CHEMBL3651512 IC50 0.5 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2(N3CCCCC3)CC2)CC1 CHEMBL3701870 IC50 0.5 nM
CC1CCN(C2(C(=O)N3C[C@H](S(=O)(=O)c4ccccc4Cl)C[C@H]3C(=O)NC3(C#N)CC3)CC2)CC1 CHEMBL3701882 IC50 0.5 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2(N3CCCCCC3)CC2)CC1 CHEMBL3701884 IC50 0.5 nM
Cc1cc(-c2ccc(S(=O)(=O)[C@@H]3C[C@@H](C(=O)NC4(C#N)CC4)N(C(=O)C4(c5ncc(Cl)cc5F)CC4)C3)c(Cl)c2)ccn1 CHEMBL4111584 IC50 0.505 nM
CCNC(=O)C(=O)[C@H](CC)NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1 CHEMBL3649404 IC50 0.508 nM
CC(C)(C)CNc1nc(C#N)ncc1C(=O)NCCc1cccc(OCCn2ccnc2)c1 CHEMBL384685 IC50 0.51 nM
CN(C#N)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 CHEMBL604281 Ki 0.51 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Br)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649376 IC50 0.52 nM
N#Cc1nc(N2C[C@@H](S(=O)(=O)c3ccccc3C(F)(F)F)CC2C(N)=O)cc(C(F)(F)F)n1 CHEMBL3651496 IC50 0.52 nM
CN1CC(C(=O)N2C[C@H](S(=O)(=O)c3ccccc3Cl)C[C@H]2C(=O)NC2(C#N)CC2)(c2ncc(Br)cc2F)C1 CHEMBL3671335 IC50 0.525 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(F)cc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649409 IC50 0.527 nM
N#Cc1nc(N2CC[C@H](S(=O)(=O)c3ccc(OCC(F)(F)F)cc3Cl)C2)cc(C(F)(F)F)n1 CHEMBL3651504 IC50 0.535 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3cc(C(F)(F)F)ccc3Cl)CN2C(=O)C2(c3ncc(Cl)cc3F)CC2)CC1 CHEMBL4114176 IC50 0.543 nM
CC(C)CS(=O)(=O)C[C@H](NC(=O)c1ccccc1)C(=O)N(C)N(C)C#N CHEMBL2153161 Ki 0.55 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649385 IC50 0.55 nM
Cc1cnc(C#N)nc1N1CC[C@H](S(=O)(=O)c2ccccc2C(F)(F)F)C1 CHEMBL3651494 IC50 0.55 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(F)cc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649400 IC50 0.558 nM
CCC(C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@H](C=O)Cc1cc2ccccc2[nH]1 CHEMBL197958 Ki app 0.56 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649381 IC50 0.56 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC(C)C CHEMBL3649402 IC50 0.568 nM
C[C@@H]1CC[C@H](NC(=O)[C@H](CCC2CCCC2)NC(=O)N2CCOCC2)C(=O)CN1S(=O)(=O)c1ccccn1 CHEMBL1807700 IC50 0.58 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649380 IC50 0.593 nM
CC(C)(C)C[C@H](NC(=O)N1CCOCC1)C(=O)N[C@H](C#N)COCc1ccccc1 CHEMBL153783 Kd 0.6 nM
N#C[C@H](COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cnccn1 CHEMBL153248 Kd 0.6 nM
N#CC1(NC(=O)[C@H](CS(=O)(=O)CC2CC2)N[C@@H](c2ccccc2)C(F)(F)F)CC1 CHEMBL249712 IC50 0.6 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2cccc(C#N)c2)cc1 CHEMBL515769 Ki 0.6 nM
CCC[C@H](NC(=O)[C@@H]1[C@H]2CCC[C@H]2CN1C(=O)[C@@H](N[C@H]([C@@H](NC(=O)c1cnccn1)C1CCCCC1)C(F)(F)F)C(C)(C)C)C(=O)C(=O)NC1CC1 CHEMBL2205017 IC50 0.6 nM
C[C@H](C#N)n1cc([C@@H](NC(=O)c2ccsc2)C2CCCCC2)nn1 CHEMBL2207571 IC50 0.6 nM
C[C@H](C#N)n1cc([C@@](C)(NC(=O)c2ccsc2)C2CCCCC2)nn1 CHEMBL2207570 IC50 0.6 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(I)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649379 IC50 0.6 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3F)CN2C(=O)C2(c3ncc(I)cc3F)CC2)CC1 CHEMBL4112088 IC50 0.6 nM
CN1CCN(C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](/C=C/S(=O)(=O)c2ccccc2)CCc2ccccc2)CC1 CHEMBL91704 IC50 0.6 nM
COc1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ccc(Cl)cn4)CC3)C2)c(Cl)c1 CHEMBL4110540 IC50 0.6 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(F)cc3Cl)CN2C(=O)C2(c3ccc(Cl)cc3F)CC2)CC1 CHEMBL4107778 IC50 0.602 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3cc(C(F)(F)F)ccc3Cl)CN2C(=O)C2(c3ccc(Cl)cn3)CC2)CC1 CHEMBL4113296 IC50 0.618 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCCOC CHEMBL3649414 IC50 0.63 nM
N#Cc1nccc(N2CC[C@@H](S(=O)(=O)c3ccccc3Br)C2)n1 CHEMBL3651481 IC50 0.63 nM
N#Cc1ncc(C(=O)NC2(c3ccc(F)cc3)CC2)c(N2CC[C@H](S(=O)(=O)c3ccccc3C(F)(F)F)C2)n1 CHEMBL3651513 IC50 0.63 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(Cl)cc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649403 IC50 0.634 nM
N#Cc1ncc(F)c(N2CC[C@H](S(=O)(=O)c3ccccc3C(F)(F)F)C2)n1 CHEMBL3651475 IC50 0.65 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(I)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649378 IC50 0.652 nM
N#Cc1ncc(C(=O)NC2CC2c2ccccc2)c(N2CC[C@H](S(=O)(=O)c3ccccc3C(F)(F)F)C2)n1 CHEMBL3651514 IC50 0.66 nM
C[C@H](NC(=O)[C@@H]1C[C@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1c1ccnc(C#N)n1)C(F)(F)F CHEMBL3651485 IC50 0.665 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Br)cc2F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649375 IC50 0.668 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649382 IC50 0.668 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(OCC(F)(F)F)cc3Cl)CN2C(=O)C2(c3ncc(Cl)cc3F)CC2)CC1 CHEMBL4112900 IC50 0.675 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CCOCC1 CHEMBL3649413 IC50 0.676 nM
Cn1cc(-c2ccc(S(=O)(=O)[C@@H]3C[C@@H](C(=O)NC4(C#N)CC4)N(C(=O)C4(c5ncc(I)cc5F)CC4)C3)c(Cl)c2)cn1 CHEMBL4106618 IC50 0.678 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(-c4ccnc(Cl)c4)cc3Cl)CN2C(=O)C2(c3ncc(Cl)cc3F)CC2)CC1 CHEMBL4106806 IC50 0.686 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(OCC(F)(F)F)cc3Cl)CN2C(=O)C2(c3ccc(Cl)cn3)CN(CC(F)F)C2)CC1 CHEMBL3671329 IC50 0.694 nM
Cn1cc(-c2ccc(S(=O)(=O)[C@@H]3C[C@@H](C(=O)NC4(C#N)CC4)N(C(=O)C4(c5ncc(C(F)(F)F)cc5F)CC4)C3)c(Cl)c2)cn1 CHEMBL4112897 IC50 0.696 nM
N#C[C@H](COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccncc1 CHEMBL356155 Kd 0.7 nM
O=C(N[C@@H](CC1CCCCC1)C(=O)N[C@@H]1C(=O)N2CCS(=O)(=O)[C@@H]12)OCc1ccccc1 CHEMBL114410 IC50 0.7 nM
COc1ccc(CCNC(=O)c2cnc(C#N)nc2NC2CCCCC2)cc1 CHEMBL218024 IC50 0.7 nM
N#CC1(NC(=O)[C@H](CS(=O)(=O)Cc2c(F)cccc2F)N[C@@H](c2ccc(F)cc2)C(F)(F)F)CC1 CHEMBL427883 IC50 0.7 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2sc(C)nc2C)cc1 CHEMBL474458 Ki 0.7 nM
C[C@@](NC(=O)c1ccsc1)(c1cn(C2(C#N)CC2)nn1)[C@H]1CC[C@H](C)CC1 CHEMBL2207567 IC50 0.7 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3)C[C@H]2C(=O)N2CCOCC2)CC1 CHEMBL3093947 IC50 0.7 nM
N#CCNC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2)C[C@H]1C(=O)N1CCOCC1 CHEMBL3093940 IC50 0.7 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3F)CN2C(=O)C2(c3ncc(Cl)cc3F)CC2)CC1 CHEMBL4111154 IC50 0.7 nM
Cn1cc(-c2ccc(S(=O)(=O)[C@@H]3C[C@@H](C(=O)NC4(C#N)CC4)N(C(=O)C4(c5ncc(Cl)cc5Cl)CC4)C3)c(Cl)c2)cn1 CHEMBL4106540 IC50 0.703 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649374 IC50 0.704 nM
CCN1CC(C(=O)N2C[C@H](S(=O)(=O)c3ccccc3Cl)C[C@H]2C(=O)NC2(C#N)CC2)(c2ncc(Br)cc2F)C1 CHEMBL3671336 IC50 0.721 nM
CCN(CC)C(=O)[C@@H]1C[C@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1c1ccnc(C#N)n1 CHEMBL3651486 IC50 0.73 nM
CCCCNC(=O)C(=O)[C@H](CCC)NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1 CHEMBL3649393 IC50 0.734 nM
COc1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ncc(Br)cc4F)CC3)C2)c(Cl)c1 CHEMBL4112501 IC50 0.734 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)c1nc2ccccc2o1 CHEMBL3649373 IC50 0.737 nM
C[C@@H]1CC[C@H](NC(=O)[C@H](CC2CCCC2)NC(=O)c2ccco2)C(=O)CN1S(=O)(=O)c1ccccn1 CHEMBL1807646 IC50 0.76 nM
Cn1cnc2c(-c3ccc(OCCC4CCN(CCO)CC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3955859 IC50 0.76 nM
Cc1ncccc1-c1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ncc(C(F)(F)F)cc4F)CC3)C2)c(Cl)c1 CHEMBL4108889 IC50 0.768 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3cccc(-c4ccc(F)cc4)c3)CN2C(=O)C2(c3ncc(Cl)cc3F)CC2)CC1 CHEMBL4114577 IC50 0.77 nM
CCCC(C)NC(=O)C(=O)[C@H](CC)NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1 CHEMBL3649397 IC50 0.776 nM
CC(C)(C)OC(=O)NN(C#N)CC(=O)N1CCOCC1 CHEMBL3342183 Ki 0.777 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(OCC(F)(F)F)cc3Cl)CN2C(=O)C2(c3ccc(Br)cn3)CN(CC(F)F)C2)CC1 CHEMBL3671330 IC50 0.779 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCC CHEMBL3649405 IC50 0.779 nM
Cc1ncccc1-c1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ncc(Cl)cc4Cl)CC3)C2)c(Cl)c1 CHEMBL4115527 IC50 0.779 nM
C[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649395 IC50 0.787 nM
Cn1cc(-c2ccc(S(=O)(=O)[C@@H]3C[C@@H](C(=O)NC4(C#N)CC4)N(C(=O)C4(c5ncc(Cl)cc5F)CCN4)C3)c(Cl)c2)cn1 CHEMBL3671356 IC50 0.791 nM
N#C[C@H](CCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)N1CCOCC1 CHEMBL153239 Kd 0.8 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2ccccc2C#N)cc1 CHEMBL514299 Ki 0.8 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2ccccc2)cc1 CHEMBL482388 Ki 0.8 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)c2ccccc2)CC1 CHEMBL3093934 IC50 0.8 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3)C[C@H]2C(=O)N2CCCCC2)CC1 CHEMBL3093825 IC50 0.8 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2CCN2C2CCOCC2)CC1 CHEMBL3701850 IC50 0.8 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2(N3CCOCC3)CC2)CC1 CHEMBL3701883 IC50 0.8 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3OC(F)(F)F)CN2C(=O)C2(N3CCCCC3)CC2)CC1 CHEMBL3701889 IC50 0.8 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(Cl)cc3)CN2C(=O)C2(N3CCCCC3)CC2)CC1 CHEMBL3701891 IC50 0.8 nM
Cn1nnc2c(C#N)nc(-c3ccc(OCCC4CCNCC4)c(C(F)(F)F)c3)cc21 CHEMBL3669133 IC50 0.8 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(OCC(F)(F)F)cc3Cl)CN2C(=O)C2(c3ccc(Cl)cn3)CC2)CC1 CHEMBL4115116 IC50 0.825 nM
CCCCNC(=O)C(=O)[C@H](CC)NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1 CHEMBL3649392 IC50 0.827 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(C)cc2C)CN1C(=O)OC(C)(C)C)C(=O)C(=O)NC1CC1 CHEMBL3649362 IC50 0.829 nM
CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N(C)N(C)C#N CHEMBL1651351 Ki 0.83 nM
CN(C#N)N(C)C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1 CHEMBL1651353 Ki 0.86 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCC(C)C CHEMBL3649415 IC50 0.876 nM
N#Cc1nccc(N2C[C@@H](S(=O)(=O)c3ccccc3C(F)(F)F)C[C@H]2C(=O)NC2(C#N)CC2)n1 CHEMBL3651492 IC50 0.883 nM
CC(C)(C)C[C@H](NC(=O)N1CCOCC1)C(=O)N[C@H](C#N)CCc1ccccc1 CHEMBL348679 Kd 0.9 nM
CC(C)(C)CNc1nc(C#N)ncc1C(=O)NCCc1ccc(OCCn2ccnc2)cc1 CHEMBL218007 IC50 0.9 nM
COc1cccc(CCNC(=O)c2cnc(C#N)nc2NCC(C)(C)C)c1 CHEMBL221707 IC50 0.9 nM
CCCC[C@@H](C=O)n1cc([C@@](C)(NC(=O)c2ccsc2)C(C)C)nn1 CHEMBL227896 Ki 0.9 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2cnccc2C)cc1 CHEMBL473448 Ki 0.9 nM
CN1CCC(C#N)(NC(=O)[C@H](CC2CCCCC2)NC(=O)N2CCOCC2)CC1 CHEMBL1236882 IC50 0.9 nM
N#CCNC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2C(F)(F)F)C[C@H]1C(=O)N1CCOCC1 CHEMBL3093942 IC50 0.9 nM
C[C@H](Oc1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ncc(Br)cc4F)CN(C=O)C3)C2)c(Cl)c1)C(F)(F)F CHEMBL3671359 IC50 0.9 nM
Cc1nsc(N2CCC(N3CCC3C(=O)N3C[C@H](S(=O)(=O)c4ccccc4Cl)C[C@H]3C(=O)NC3(C#N)CC3)CC2)n1 CHEMBL3701849 IC50 0.9 nM
CC1CCCCN1C1(C(=O)N2C[C@H](S(=O)(=O)c3ccccc3Cl)C[C@H]2C(=O)NC2(C#N)CC2)CC1 CHEMBL3701885 IC50 0.9 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCCc1ccccc1 CHEMBL3649410 IC50 0.901 nM
N#Cc1nccc(N2C[C@@H](S(=O)(=O)c3ccccc3C(F)(F)F)C[C@H]2C(=O)NCC(F)(F)F)n1 CHEMBL3651483 IC50 0.935 nM
N#Cc1nc2c(c(N3CC[C@H](S(=O)(=O)c4ccc(-n5cccn5)cc4Cl)C3)n1)CN(CC(F)(F)F)C2 CHEMBL3651515 IC50 0.945 nM
Cn1cc(-c2ccc(S(=O)(=O)[C@@H]3C[C@@H](C(=O)NC4(C#N)CC4)N(C(=O)C4(c5ncc(Cl)cc5F)CCN4C(=O)OC(C)(C)C)C3)c(Cl)c2)cn1 CHEMBL3671354 IC50 0.965 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(Br)cc2C(F)(F)F)CN1c1cc(C)nn1C1CCC1)C(=O)C(=O)NC1CC1 CHEMBL3649367 IC50 0.976 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649383 IC50 0.983 nM
N#C[C@@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)N1CCOCC1)c1ccccc1 CHEMBL435440 Kd 1.0 nM
COc1ccc(NC[C@H](C)NC(=O)[C@H](CC2CCCCC2)Nc2nc3cccc(Cl)c3o2)cc1 CHEMBL381355 Ki 1.0 nM
CC(C)C[C@@H](NC(=O)N1CCOCC1)C(=O)N[C@@H](/C=C/S(=O)(=O)c1ccccc1)CCc1ccccc1 CHEMBL222649 IC50 1.0 nM
CN1CCC(Oc2nc(C#N)nc(NCC3CCC4(CC3)CC4)c2C(=O)NCc2ccccc2)CC1 CHEMBL458482 IC50 1.0 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2cccc(OC)c2)cc1 CHEMBL475669 Ki 1.0 nM
CS(=O)(=O)N1CCc2c(c(-c3ccc(C(F)(F)F)c(SCC(=O)N4CCCC4)c3)nn2CC(O)CN2CCC(c3ccccn3)CC2)C1 CHEMBL1090993 IC50 1.0 nM
CC(NC(=O)c1ccc(OCc2ccccn2)c(C(F)(F)F)c1Cl)C(=O)C(=O)Nc1ccn(C)n1 CHEMBL1289644 IC50 1.0 nM
N#CC1(n2cc([C@@H](NC(=O)c3csc(-c4ccccc4)c3)C3CCCCC3)nn2)CC1 CHEMBL2207587 IC50 1.0 nM
CC(C)(C#N)n1cc([C@@](C)(NC(=O)c2ccsc2)[C@H]2CC[C@H](C)CC2)nn1 CHEMBL2207566 IC50 1.0 nM
CC(=O)N1C[C@H](S(=O)(=O)c2ccccc2Cl)C[C@H]1C(=O)NC1(C#N)CC1 CHEMBL3093936 IC50 1.0 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3)C[C@H]2C(=O)N2CCC(O)CC2)CC1 CHEMBL3093829 IC50 1.0 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3)C[C@H]2C(=O)N2CC3CCC(C2)O3)CC1 CHEMBL3093823 IC50 1.0 nM
C[C@H](Oc1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ncc(Br)cc4F)CN(CC(F)(F)F)C3)C2)c(Cl)c1)C(F)(F)F CHEMBL3671361 IC50 1.0 nM
C[C@H](Oc1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ncc(Br)cc4F)CN(CC(F)F)C3)C2)c(Cl)c1)C(F)(F)F CHEMBL3671358 IC50 1.0 nM
N#CC1(NC(=O)[C@H](CC(F)(F)Cc2ccccc2)NC(=O)N2CCC3(CC2)CCN(C2CC2)CC3)CC1 CHEMBL3640727 Ki 1.0 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2CCN2C2CCC(F)(F)CC2)CC1 CHEMBL3701847 IC50 1.0 nM
CCN1CCC(CCOc2ncc(-c3nc(C#N)nc4c3ncn4C)cc2C(F)(F)F)CC1 CHEMBL3913427 IC50 1.0 nM
CN1CCC[C@@H]1C(=O)N1CCC(CCOc2ncc(-c3nc(C#N)nc4c3ncn4C)cc2C(F)(F)F)CC1 CHEMBL4107080 IC50 1.0 nM
Cn1cnc2c(-c3cnc(OCCC4CCN(C(CF)CF)CC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3890680 IC50 1.0 nM
CC(C)C[C@H](NC(=O)c1ccc(CN2CCN(C)CC2)cc1)C(=O)NC1(C#N)CCS(=O)(=O)CC1 CHEMBL4228143 IC50 1.0 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2(c3ncc(Br)cc3F)CNC2)CC1 CHEMBL3671334 IC50 1.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1c1ccccc1[N+](=O)[O-])C(=O)C(=O)NC1CC1 CHEMBL3649364 IC50 1.002 nM
CCCC(C)NC(=O)C(=O)[C@H](CCC)NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1 CHEMBL3649398 IC50 1.024 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCC(F)(F)F CHEMBL3649401 IC50 1.06 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2(c3ncc(Cl)cc3F)CNC2)CC1 CHEMBL3671333 IC50 1.066 nM
C[C@H](Oc1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ncc(Cl)cc4F)CCN3C(=O)OC(C)(C)C)C2)c(Cl)c1)C(F)(F)F CHEMBL3671341 IC50 1.078 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2ccc(C#N)cc2)cc1 CHEMBL514195 Ki 1.1 nM
CCC(NC(=O)c1ccc(OCc2ccccn2)c(C(F)(F)F)c1Cl)C(=O)C(N)=O CHEMBL1289536 IC50 1.1 nM
CCC(NC(=O)c1ccc(OCc2ccccn2)c(C(F)(F)F)c1Cl)C(=O)C(=O)Nc1ccn(C)n1 CHEMBL1289645 IC50 1.1 nM
C[C@@](NC(=O)c1ccsc1)(c1cn(C2(C#N)CC2)nn1)C1CCCCC1 CHEMBL2207568 IC50 1.1 nM
CCC(NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2)CN1C(=O)c1cccc(Cl)c1)C(=O)c1nc2ccccc2o1 CHEMBL2380725 IC50 1.1 nM
CC(C)C[C@H](NC(=O)c1ccc(-c2ccccc2)cc1)C(=O)NC1(C#N)CCS(=O)(=O)CC1 CHEMBL4228926 IC50 1.1 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCc1ccccc1 CHEMBL3649394 IC50 1.114 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(Cl)cc2C)CN1C(=O)OC(C)(C)C)C(=O)C(=O)NC1CC1 CHEMBL3649363 IC50 1.122 nM
Cn1cc(-c2ccc(S(=O)(=O)[C@@H]3C[C@@H](C(=O)NC4(C#N)CC4)N(C(=O)C4(c5ncc(Br)cc5F)CCN4C(=O)OC(C)(C)C)C3)c(Cl)c2)cn1 CHEMBL3671355 IC50 1.124 nM
COc1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ccc(Cl)cn4)CN(C)C3)C2)c(Cl)c1 CHEMBL3671324 IC50 1.198 nM
C[C@@H]1CC[C@H](NC(=O)[C@H](CC2CCC(C)(C)CC2)NC(=O)c2ccco2)C(=O)CN1S(=O)(=O)c1ccccn1 CHEMBL1807699 IC50 1.2 nM
N#Cc1ncc(C(=O)NCC(F)(F)F)c(N2CC[C@H](S(=O)(=O)c3ccc(-n4ccnc4)cc3Cl)C2)n1 CHEMBL3651516 IC50 1.2 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2(N3CCCC3)CC2)CC1 CHEMBL3701873 IC50 1.2 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2(N3CCC(c4ccccc4)CC3)CC2)CC1 CHEMBL3640007 IC50 1.2 nM
CCN1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ncn4C)cc2C(F)(F)F)CC1 CHEMBL3983448 IC50 1.2 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCc1ccccc1 CHEMBL3649396 IC50 1.213 nM
CC(C)(C)OC(=O)N1CC(C(=O)N2C[C@H](S(=O)(=O)c3ccccc3Cl)C[C@H]2C(=O)NC2(C#N)CC2)(c2ncc(Cl)cc2F)C1 CHEMBL3671331 IC50 1.26 nM
CC(C)C[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649390 IC50 1.265 nM
CC(C)(C)OC(=O)N1CC(C(=O)N2C[C@H](S(=O)(=O)c3ccccc3Cl)C[C@H]2C(=O)NC2(C#N)CC2)(c2ncc(Br)cc2F)C1 CHEMBL3671332 IC50 1.269 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(F)cc3Cl)CN2C(=O)C2(c3ncc(Cl)cc3F)CCN2)CC1 CHEMBL3671343 IC50 1.299 nM
N#CC1(NC(=O)[C@H](CS(=O)(=O)c2nc3ccccc3s2)N[C@@H](c2ccccc2)C(F)(F)F)CC1 CHEMBL250919 IC50 1.3 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2ccc(N)cc2)cc1 CHEMBL475268 Ki 1.3 nM
CN1CCN(CCCOc2ccc(-c3ccnc(C#N)n3)cc2C(F)(F)F)CC1 CHEMBL1209146 IC50 1.3 nM
C[C@@H]1CC[C@H](NC(=O)[C@H](CC(C)(C)C)NC(=O)c2ccco2)C(=O)CN1S(=O)(=O)c1ccccn1 CHEMBL1807650 IC50 1.3 nM
CC(=O)N1CCC(N2CCC2C(=O)N2C[C@H](S(=O)(=O)c3ccccc3Cl)C[C@H]2C(=O)NC2(C#N)CC2)CC1 CHEMBL3701851 IC50 1.3 nM
Cn1ccc2c(-c3ccc(OCCC4CCNC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3936527 IC50 1.3 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(OCC(F)(F)F)cc2C(F)(F)F)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649372 IC50 1.379 nM
CCOC(=O)N1CCC(N2CCC2C(=O)N2C[C@H](S(=O)(=O)c3ccc(C)cc3)C[C@H]2C(=O)NC2(C#N)CC2)CC1 CHEMBL3701865 IC50 1.4 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2(N3CCN(C=O)CC3)CC2)CC1 CHEMBL3701879 IC50 1.4 nM
Cn1cnc2c(-c3cnc(OCCC4CCNCC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3972279 IC50 1.4 nM
CN1CCC[C@H]1C(=O)N1CCC(CCOc2ncc(-c3nc(C#N)nc4c3ncn4CC3CCOC3)cc2C(F)(F)F)CC1 CHEMBL3949239 IC50 1.4 nM
COc1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ccc(Cl)cn4)CNC3)C2)c(Cl)c1 CHEMBL3671323 IC50 1.4 nM
O=C(NC1CC1)C(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1 CHEMBL3649391 IC50 1.417 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(F)cc3Cl)CN2C(=O)C2(c3ncc(Br)cc3F)CCN2)CC1 CHEMBL3671344 IC50 1.424 nM
CCNC(=O)[C@@H]1C[C@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1c1ccnc(C#N)n1 CHEMBL3651489 IC50 1.433 nM
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N(C)N(C)C#N CHEMBL1651242 Ki 1.5 nM
C[C@@H]1CC[C@H](NC(=O)[C@H](CC23CCC(CC2)C3(C)C)NC(=O)N2CCOCC2)C(=O)CN1S(=O)(=O)c1ccccn1 CHEMBL1807702 IC50 1.5 nM
C[C@@H]1CC[C@H](NC(=O)[C@H](CC2(C)CCCCC2)NC(=O)c2ccco2)C(=O)CN1C(=O)c1ccccn1 CHEMBL1807703 IC50 1.5 nM
N#Cc1nccc(N2CC[C@H](S(=O)(=O)c3ccccc3Cl)C2)n1 CHEMBL3651471 IC50 1.5 nM
N#Cc1nccc(N2C[C@@H](S(=O)(=O)c3ccccc3C(F)(F)F)C[C@H]2C(=O)O)n1 CHEMBL3651487 IC50 1.5 nM
CCOC(=O)N1CCC(N2CCC2C(=O)N2C[C@H](S(=O)(=O)c3ccc(F)cc3Cl)C[C@H]2C(=O)NC2(C#N)CC2)CC1 CHEMBL3701859 IC50 1.5 nM
CN(C)C(=O)CN1CCC(CCOc2ccc(-c3cc4c(nnn4C)c(C#N)n3)cc2C(F)(F)F)CC1 CHEMBL3669129 IC50 1.5 nM
CN1CCC(CCOc2ncc(-c3nc(C#N)nc4c3ncn4C)cc2C(F)(F)F)CC1 CHEMBL3904895 IC50 1.5 nM
Cn1cnc2c(-c3cnc(OCCC4CCN5CCCC5C4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3934589 IC50 1.5 nM
CN1CCC[C@@H]1C(=O)N1CC[C@H](OCCOc2ncc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)C1 CHEMBL3946105 IC50 1.5 nM
Cn1ccc2c(-c3cnc(OCC4CCN(CC(C)(C)O)CC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3947366 IC50 1.5 nM
Cc1cc(-c2ccc(S(=O)(=O)[C@@H]3C[C@@H](C(=O)NC4(C#N)CC4)N(C(=O)C4(c5ncc(Cl)cc5F)CCN4C(=O)OC(C)(C)C)C3)c(Cl)c2)ccn1 CHEMBL3671350 IC50 1.553 nM
C[C@H](Oc1ccc(S(=O)(=O)[C@@H]2CC(C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ncc(Cl)cc4F)CC3)C2)c(Cl)c1)C(F)(F)F CHEMBL3927257 IC50 1.596 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@H]1CC[C@@H](C)N(S(=O)(=O)c2ccccn2)CC1=O CHEMBL203665 Ki app 1.6 nM
COc1ccc(CCNC(=O)c2cnc(C#N)nc2NCC(C)(C)C)cc1 CHEMBL220496 IC50 1.6 nM
N#CC1(NC(=O)[C@H](CC2CCCCC2)NC(=O)N2CCOCC2)CC1 CHEMBL2207560 IC50 1.6 nM
CCOC(=O)N1CCC(N2CCC2C(=O)N2C[C@H](S(=O)(=O)c3cccc(C(F)(F)F)c3)C[C@H]2C(=O)NC2(C#N)CC2)CC1 CHEMBL3701869 IC50 1.6 nM
CN1CCN(C(=O)Cn2ccc3c(-c4ccc(OCCC5CCOCC5)c(C(F)(F)F)c4)nc(C#N)nc32)CC1 CHEMBL3945034 IC50 1.6 nM
Cn1cnc2c(-c3ccc(OCCC4CCN(CC(=O)N5CCCC5)CC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3910213 IC50 1.6 nM
Cn1ccc2c(-c3cnc(OCC4CCNCC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3935832 IC50 1.6 nM
N#Cc1nccc(N2C[C@@H](S(=O)(=O)c3ccccc3C(F)(F)F)C[C@H]2C(=O)N2CCC2)n1 CHEMBL3651484 IC50 1.65 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(OCC(F)(F)F)cc3Cl)CN2C(=O)C2(c3ncc(Br)cc3F)CNC2)CC1 CHEMBL3671337 IC50 1.666 nM
O=C(N[C@H](C(=O)N1C[C@H](Cl)[C@H]2OCC(=O)[C@H]21)C1CCCCC1)c1cccc(-n2ccnc2)c1 CHEMBL3648411 Ki 1.7 nM
C[C@H](Oc1ccc(S(=O)(=O)[C@H]2CCN(c3cc(C(F)(F)F)nc(C#N)n3)C2)c(Cl)c1)C(F)(F)F CHEMBL3651501 IC50 1.7 nM
N#Cc1nc2c(c(N3CC[C@H](S(=O)(=O)c4ccc(OCC(F)(F)F)cc4Cl)C3)n1)CN(CC(F)(F)F)C2 CHEMBL3651517 IC50 1.7 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2CCN2C2CCCCC2)CC1 CHEMBL3701846 IC50 1.7 nM
CCOC(=O)N1CCC(N2CCC2C(=O)N2C[C@H](S(=O)(=O)c3ccccc3Cl)C[C@H]2C(=O)NC2(C#N)CC2)CC1 CHEMBL3701856 IC50 1.7 nM
Cn1cnc2c(-c3ccc(OCCC4CCNCC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3937129 IC50 1.7 nM
Cn1ccc2c(-c3ccc(SCCC4CCNCC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3911400 IC50 1.7 nM
Cn1cnc2c(-c3ccc(OCCC4CCN(CC(=O)N5CC[C@H](F)C5)CC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3976653 IC50 1.7 nM
CN1CCC[C@H]1C(=O)N1CC[C@H](OCCOc2ncc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)C1 CHEMBL3948988 IC50 1.7 nM
O=C(NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCc1ccccc1)N/C=C/S(=O)(=O)c1ccc2ccccc2c1)NN1CCOCC1 CHEMBL3142836 Ki 1.8 nM
CN1CCN(c2cccc(CCNC(=O)c3cnc(C#N)nc3NCC(C)(C)C)c2)CC1 CHEMBL414530 IC50 1.8 nM
N#CC1(NC(=O)[C@H](CS(=O)(=O)Cc2ccccc2-c2ccccc2)N[C@@H](c2ccc(F)cc2)C(F)(F)F)CC1 CHEMBL251101 IC50 1.8 nM
CS(=O)(=O)C[C@H](N[C@@H](c1ccc(F)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL249915 IC50 1.8 nM
N#CC1(n2cc([C@@H](NC(=O)c3ccccc3)C3CCCCC3)nn2)CC1 CHEMBL2207588 IC50 1.8 nM
N#Cc1nccc(N2C[C@@H](S(=O)(=O)c3ccccc3C(F)(F)F)C[C@H]2C(N)=O)n1 CHEMBL3651518 IC50 1.8 nM
CCOC(=O)N1CCC(N2CCC2C(=O)N2C[C@H](S(=O)(=O)c3cccc(Cl)c3)C[C@H]2C(=O)NC2(C#N)CC2)CC1 CHEMBL3701864 IC50 1.8 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1c1ccccc1[N+](=O)[O-])C(=O)c1nc2ccccc2o1 CHEMBL3649366 IC50 1.83 nM
Cn1cc(-c2ccc(S(=O)(=O)[C@@H]3C[C@@H](C(=O)NC4(C#N)CC4)N(C(=O)C4(c5ncc(Br)cc5F)CCN4)C3)c(Cl)c2)cn1 CHEMBL3671357 IC50 1.854 nM
N#C[C@@]1(NC(=O)[C@@H](CC(=O)N2CCOCC2)CC2CCc3ccccc3C2)CCN(C2CCCCC2)C1 CHEMBL234912 IC50 1.9 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)CC)cc1 CHEMBL480381 Ki 1.9 nM
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cccc([N+](=O)[O-])c1 CHEMBL1086235 IC50 1.9 nM
CCCCC(NC(=O)c1ccc(OCc2ccccn2)c(C(F)(F)F)c1Cl)C(=O)C(=O)Nc1ccn(C)n1 CHEMBL1289750 IC50 1.9 nM
C[C@@H]1CC[C@H](NC(=O)[C@H](CCC2CCCC2)NC(=O)c2ccco2)C(=O)CN1S(=O)(=O)c1ccccn1 CHEMBL1807697 IC50 1.9 nM
CCN1CCC(CCOc2ccc(-c3nc(C#N)nc4c3nc(C)n4C)cc2C(F)(F)F)CC1 CHEMBL3926794 IC50 1.9 nM
CN(C)C(=O)CN1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4CCO)cc2C(F)(F)F)CC1 CHEMBL3961161 IC50 1.9 nM
N#Cc1nc(-c2ccc(OCCC3CCNCC3)c(C(F)(F)F)c2)c2ccn(CC3CCOC3)c2n1 CHEMBL3984479 IC50 1.9 nM
CCN1CCC(CCOc2ncc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)CC1 CHEMBL3901142 IC50 1.9 nM
N#Cc1nc(-c2ccc(OCC3CCNCC3)c(C(F)(F)F)c2)c2ccn(CC3CCOC3)c2n1 CHEMBL3953803 IC50 1.9 nM
Cn1cnc2c(-c3cc(F)c(OCCC4CCNCC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3890549 IC50 1.9 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCc1cccc2ccccc12 CHEMBL3649412 IC50 1.959 nM
CC(C)C[C@H](NC(=O)N1CCOCC1)C(=O)N[C@H](C#N)COCc1ccc(Cl)cc1 CHEMBL151642 Kd 2.0 nM
COc1ccc(NCCNC(=O)[C@H](CC2CCCCC2)NC(=O)c2ccc(Nc3nc(C)cc(C)n3)cc2)cc1 CHEMBL194405 Ki 2.0 nM
CNC(=O)c1c(NCC2CCC3(CC2)CC3)nc(C#N)nc1OCCC1CCN(C)CC1 CHEMBL514545 IC50 2.0 nM
CN1CCC(Cc2ccccc2)(NC(=O)c2cnc(C#N)nc2NCC2CCC3(CC2)CC3)CC1 CHEMBL456135 IC50 2.0 nM
CN1CCC(CCOc2nc(C#N)nc(NCC3CCC4(CC3)CC4)c2Br)CC1 CHEMBL526107 IC50 2.0 nM
N#Cc1ncc2cc(COc3ccc(C(N)=O)cc3)n(CCC3CCCCC3)c2n1 CHEMBL481128 IC50 2.0 nM
CC(C)(C)CCn1c(Cc2ccc(Cl)cc2)cc2cnc(C#N)nc21 CHEMBL523336 IC50 2.0 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1 CHEMBL474664 Ki 2.0 nM
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccc(OC(C)=O)cc1 CHEMBL1085728 IC50 2.0 nM
CCC[C@H](NC(=O)[C@@H]1[C@H]2CCC[C@H]2CN1C(=O)[C@@H](N[C@@H]([C@@H](NC(=O)c1cnccn1)C1CCCCC1)C(F)(F)F)C(C)(C)C)C(=O)C(=O)NC1CC1 CHEMBL2205016 IC50 2.0 nM
C[C@@](NCc1ccsc1)(c1cn(C2(C#N)CC2)nn1)C1CCCCC1 CHEMBL2207152 IC50 2.0 nM
CCC(NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2)CN1C(=O)c1ccc(Cl)cc1)C(=O)c1nc2ccccc2o1 CHEMBL2380724 IC50 2.0 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3C(F)(F)F)CN2)CC1 CHEMBL3093932 IC50 2.0 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3)C[C@H]2C(=O)N2CCCC2)CC1 CHEMBL3093928 IC50 2.0 nM
CN1CCN(C(=O)[C@@H]2C[C@H](S(=O)(=O)c3ccccc3)C[C@H]2C(=O)NC2(C#N)CC2)CC1 CHEMBL3093827 IC50 2.0 nM
COC(=O)N1CC(C(=O)N2C[C@H](S(=O)(=O)c3ccc(O[C@@H](C)C(F)(F)F)cc3Cl)C[C@H]2C(=O)NC2(C#N)CC2)(c2ncc(Br)cc2F)C1 CHEMBL3671360 IC50 2.0 nM
CCCC(F)(F)C[C@H](NC(=O)N1CCC2(CC1)CCN(C1CC1)CC2)C(=O)NC1(C#N)CC1 CHEMBL3640726 Ki 2.0 nM
CCCC(F)(F)C[C@H](NC(=O)N1CCC2(CC1)CCN(c1ccc(OC)cc1)C2)C(=O)NC1(C#N)CC1 CHEMBL3640725 Ki 2.0 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CCCC2)CC1)C(=O)NC1(C#N)CC1 CHEMBL3640708 Ki 2.0 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2CCN2C2CCCC2)CC1 CHEMBL3701854 IC50 2.0 nM
CCN1CCC(CCOc2ncc(-c3nc(C#N)nc4c3ncn4CC3CCOC3)cc2C(F)(F)F)CC1 CHEMBL3979112 IC50 2.0 nM
Cn1ccc2c(-c3ccc(OCCC4CCN(C(C)(C)C)CC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3970891 IC50 2.0 nM
CCN1CCC(OCCOc2ccc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)CC1 CHEMBL3910742 IC50 2.0 nM
CCN1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4CC(N)=O)cc2C(F)(F)F)CC1 CHEMBL3910974 IC50 2.0 nM
Cn1cnc2c(-c3cnc(OCCC4CCN(C5CCC5)CC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3979692 IC50 2.0 nM
N#Cc1nc(Nc2ccc(OC(F)(F)F)cc2)nc(N2CCOCC2)n1 CHEMBL4251253 Ki 2.0 nM
Cc1cc(-c2ccc(S(=O)(=O)[C@@H]3C[C@@H](C(=O)NC4(C#N)CC4)N(C(=O)C4(c5ncc(Br)cc5F)CCN4)C3)c(Cl)c2)ccn1 CHEMBL3671353 IC50 2.076 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2cccnc2)cc1 CHEMBL480638 Ki 2.1 nM
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccc(Cl)c(N)c1 CHEMBL1085970 IC50 2.1 nM
Cn1ccc2c(-c3ccc(OCCOC4CCNCC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3942551 IC50 2.1 nM
CN1CCC(NC(=O)Cn2ccc3c(-c4ccc(OCCC5CCOCC5)c(C(F)(F)F)c4)nc(C#N)nc32)CC1 CHEMBL3903423 IC50 2.1 nM
CCN1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)C1 CHEMBL3980817 IC50 2.1 nM
CN1CCC[C@H]1C(=O)N1CC(COc2ccc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)C1 CHEMBL3895204 IC50 2.1 nM
Cn1cnc2c(-c3ccc(OCCC4CCN(CC(=O)N5CCC(C#N)CC5)CC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3981481 IC50 2.1 nM
Cn1ccc2c(-c3cnc(OCC4CCN(C(=O)C5CCN(CC(C)(C)O)CC5)CC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3905933 IC50 2.1 nM
CC(C)N1CCC(CCOc2ncc(-c3nc(C#N)nc4c3ncn4C)cc2C(F)(F)F)CC1 CHEMBL3920425 IC50 2.1 nM
CC(C)N1CCC[C@H]1C(=O)N1CCC(CCOc2ncc(-c3nc(C#N)nc4c3ncn4C)cc2C(F)(F)F)CC1 CHEMBL3919375 IC50 2.1 nM
CN1CCC[C@H]1C(=O)N1CC[C@@H](OCCOc2ncc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)C1 CHEMBL4108891 IC50 2.1 nM
N#Cc1ccnc(N2CC[C@H](S(=O)(=O)c3ccc(N4CCN5CCC[C@H]5C4)cc3Cl)C2)n1 CHEMBL3651519 IC50 2.121 nM
C[C@H](Oc1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ncc(Br)cc4F)CN(C)C3)C2)c(Cl)c1)C(F)(F)F CHEMBL3671349 IC50 2.134 nM
N#Cc1ccc(C(=O)N[C@H](c2cn(C3(C#N)CC3)nn2)C2CCCCC2)cc1 CHEMBL2207590 IC50 2.2 nM
C[C@H]1CC[C@H]([C@H](NC(=O)c2cccc(-n3cnnn3)c2)C(=O)N2C[C@H](Cl)[C@H]3OCC(=O)[C@H]32)CC1 CHEMBL3648408 Ki 2.2 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2CCN2C2CCSCC2)CC1 CHEMBL3701855 IC50 2.2 nM
CC(=O)N1CCN(C2(C(=O)N3C[C@H](S(=O)(=O)c4ccccc4Cl)C[C@H]3C(=O)NC3(C#N)CC3)CC2)CC1 CHEMBL3701876 IC50 2.2 nM
N#Cc1nc(-c2ccc(OCCC3CCNCC3)c(C(F)(F)F)c2)c2cc[nH]c2n1 CHEMBL3984006 IC50 2.2 nM
CCN1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ncn4CC3CCOC3)cc2C(F)(F)F)CC1 CHEMBL3946657 IC50 2.2 nM
CN1CCC(N(C)C(=O)Cn2ccc3c(-c4ccc(OCCC5CCOCC5)c(C(F)(F)F)c4)nc(C#N)nc32)C1 CHEMBL3977110 IC50 2.2 nM
CN1CCC[C@H]1C(=O)N1CCC(COc2ccc(-c3nc(C#N)nc4c3ccn4CC3CCOC3)cc2C(F)(F)F)CC1 CHEMBL3986133 IC50 2.2 nM
CN(C)C(=O)CN1CCC(CCOc2ncc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)CC1 CHEMBL3921161 IC50 2.2 nM
N#Cc1ccnc(N2CC[C@H](S(=O)(=O)c3ccccc3C(F)(F)F)C2)n1 CHEMBL3651520 IC50 2.202 nM
C[C@H](Oc1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ncc(Br)cc4F)CCN3C(=O)OC(C)(C)C)C2)c(Cl)c1)C(F)(F)F CHEMBL3671342 IC50 2.219 nM
N#Cc1ncc(C(=O)NCCc2ccc(N3CCCC3)cc2)c(NC2CCCCC2)n1 CHEMBL217930 IC50 2.3 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2cccs2)cc1 CHEMBL482218 Ki 2.3 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2ccccn2)cc1 CHEMBL480836 Ki 2.3 nM
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccc(Br)o1 CHEMBL1083620 IC50 2.3 nM
CCC(NC(=O)c1cccc(C(F)(F)F)c1Cl)C(=O)C(=O)Nc1cc[nH]n1 CHEMBL1289305 IC50 2.3 nM
CC(C)C(NC(=O)c1ccc(OCc2ccccn2)c(C(F)(F)F)c1Cl)C(=O)C(=O)Nc1ccn(C)n1 CHEMBL1289749 IC50 2.3 nM
N#CC1(n2cc([C@@H](NC(=O)c3ccsc3)C3CCCCC3)nn2)CC1 CHEMBL2207569 IC50 2.3 nM
CCC(NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(C)=O)C(=O)c1nc2ccccc2o1 CHEMBL2380727 IC50 2.3 nM
N#Cc1nccc(N2C[C@@H](S(=O)(=O)c3ccccc3C(F)(F)F)C[C@H]2C(=O)NCc2ccc(F)cc2)n1 CHEMBL3651491 IC50 2.3 nM
CC(C)(C)OC(=O)N1CCN(C2(C(=O)N3C[C@H](S(=O)(=O)c4ccccc4Cl)C[C@H]3C(=O)NC3(C#N)CC3)CC2)CC1 CHEMBL3701874 IC50 2.3 nM
CC1(C)CCCN(C2(C(=O)N3C[C@H](S(=O)(=O)c4ccccc4Cl)C[C@H]3C(=O)NC3(C#N)CC3)CC2)C1 CHEMBL3701892 IC50 2.3 nM
Cn1ccc2c(-c3ccc(OCCC4CCNCC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3950629 IC50 2.3 nM
Cn1ccc2c(-c3ccc(OCCC4CCN(C5CC5)CC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3913227 IC50 2.3 nM
Cc1nnc(CN2CCC(CCOc3ccc(-c4nc(C#N)nc5c4ncn5C)cc3C(F)(F)F)CC2)o1 CHEMBL3949029 IC50 2.3 nM
CN1CCC[C@H]1C(=O)N1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)C1 CHEMBL3910831 IC50 2.3 nM
CCN1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4CCO)cc2C(F)(F)F)CC1 CHEMBL3967282 IC50 2.3 nM
CN1C[C@@H](O)C[C@H]1C(=O)N1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ncn4C)cc2C(F)(F)F)CC1 CHEMBL3904985 IC50 2.3 nM
CN1CCC(C(=O)N2CCC(CCOc3ccc(-c4nc(C#N)nc5c4ncn5C)cc3C(F)(F)F)CC2)C1 CHEMBL3903922 IC50 2.3 nM
Cc1cc(-c2ccc(S(=O)(=O)[C@@H]3C[C@@H](C(=O)NC4(C#N)CC4)N(C(=O)C4(c5ncc(Cl)cc5F)CCN4)C3)c(Cl)c2)ccn1 CHEMBL3671352 IC50 2.33 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1)C(=O)C(=O)NCc1ccccc1 CHEMBL3649422 IC50 2.348 nM
CC(C)(C)N1CCN(c2ccc(S(=O)(=O)[C@H]3CCN(c4nc(C#N)ncc4C(=O)NCC(F)(F)F)C3)c(Cl)c2)CC1 CHEMBL3651521 IC50 2.35 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3-n3ccnn3)CN2C(=O)C2(c3ncc(I)cc3F)CC2)CC1 CHEMBL4110244 IC50 2.372 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)C2CC2)cc1 CHEMBL479831 Ki 2.4 nM
CCC(NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2)CN1C(=O)C(C)C)C(=O)c1nc2ccccc2o1 CHEMBL2380718 IC50 2.4 nM
CCN1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4CC3CCCO3)cc2C(F)(F)F)CC1 CHEMBL3892402 IC50 2.4 nM
CCN1CCC(CCOc2ncc(-c3nc(C#N)nc4c3ccn4CC(=O)N3CCOCC3)cc2C(F)(F)F)CC1 CHEMBL3909911 IC50 2.4 nM
Cn1cnc2c(-c3ccc(OCCC4CCN(CC(=O)N5CCC(F)(F)C5)CC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3914918 IC50 2.4 nM
Cn1ccc2c(-c3cnc(OCCOC4CCNCC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3950504 IC50 2.4 nM
Cn1ccc2c(-c3cnc(OCC4CCN(C(=O)[C@@H]5CCCN5)CC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3962861 IC50 2.4 nM
CC(C)N1CCC[C@H]1C(=O)N1CCC(COc2ncc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)CC1 CHEMBL3899258 IC50 2.4 nM
CN1CCC[C@@H]1C(=O)N1CC[C@@H](OCCOc2ncc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)C1 CHEMBL4113812 IC50 2.4 nM
Cn1ccc2c(-c3cnc(OCC4CCN(C(=O)C5CCN(C6CCOCC6)CC5)CC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3957498 IC50 2.4 nM
CN1CCN(Cc2ccc(CCNC(=O)c3cnc(C#N)nc3NCC(C)(C)C)cc2)CC1 CHEMBL374890 IC50 2.5 nM
CS(=O)(=O)C[C@H](N[C@@H](c1ccccc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL249507 IC50 2.5 nM
CC1(C)CC(N2CCC2C(=O)N2C[C@H](S(=O)(=O)c3ccccc3Cl)C[C@H]2C(=O)NC2(C#N)CC2)CCO1 CHEMBL3701853 IC50 2.5 nM
CS(=O)(=O)N1CCN(C2(C(=O)N3C[C@H](S(=O)(=O)c4ccccc4Cl)C[C@H]3C(=O)NC3(C#N)CC3)CC2)CC1 CHEMBL3701877 IC50 2.5 nM
N#Cc1nc(-c2ccc(OCCC3CCOCC3)c(C(F)(F)F)c2)c2ccn(CC(=O)N3CCC(CN4CCCC4)CC3)c2n1 CHEMBL3902944 IC50 2.5 nM
Cn1ccc2c(-c3cnc(OCCC4CCNCC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3975765 IC50 2.5 nM
N#CCNC(=O)[C@H](Cc1cccc(-c2nncs2)c1)NC(=O)c1ccccc1 CHEMBL559880 pIC50 2.512 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(N3CCOCC3)cc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649416 IC50 2.568 nM
COc1ccc(CCNC(=O)c2cnc(C#N)nc2NCC(C)(C)C)cc1OCCn1ccnc1 CHEMBL436303 IC50 2.6 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(C)(=O)=O)cc1 CHEMBL471972 Ki 2.6 nM
COC(=O)N1CCN(C2(C(=O)N3C[C@H](S(=O)(=O)c4ccccc4Cl)C[C@H]3C(=O)NC3(C#N)CC3)CC2)CC1 CHEMBL3701878 IC50 2.6 nM
CN(C)C(=O)CN1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)CC1 CHEMBL3926439 IC50 2.6 nM
CCN1CCN(C(=O)COc2ccc(-c3nc(C#N)nc4c3ncn4C)cc2C(F)(F)F)CC1 CHEMBL3902381 IC50 2.6 nM
CCN1CCC(CCOc2ncc(-c3nc(C#N)nc4c3ccn4CC3CCOC3)cc2C(F)(F)F)CC1 CHEMBL3979251 IC50 2.6 nM
N#Cc1nc(-c2ccc(OCCC3CCNCC3)c(C(F)(F)F)c2)c2ccn(CC3CCCO3)c2n1 CHEMBL3969835 IC50 2.6 nM
N#Cc1nc(-c2ccc(OCCC3CCNCC3)c(C(F)(F)F)c2)c2ccn(C3CCOCC3)c2n1 CHEMBL3978347 IC50 2.6 nM
CC(C)C[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649419 IC50 2.608 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2ccncc2)cc1 CHEMBL481424 Ki 2.7 nM
CCC(NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2)CN1C(=O)C(F)(F)F)C(=O)c1nc2ccccc2o1 CHEMBL2380720 IC50 2.7 nM
CC(CNC(=O)c1cnc(C#N)nc1N1CC[C@H](S(=O)(=O)c2ccc(N3CCN(C(C)(C)C)CC3)cc2Cl)C1)c1ccc(Cl)cc1 CHEMBL3651522 IC50 2.7 nM
CS(=O)(=O)N1CCC(N2CCC2C(=O)N2C[C@H](S(=O)(=O)c3ccccc3Cl)C[C@H]2C(=O)NC2(C#N)CC2)CC1 CHEMBL3701857 IC50 2.7 nM
Cc1nc2c(-c3ccc(OCCC4CCNCC4)c(C(F)(F)F)c3)nc(C#N)nc2n1C CHEMBL3898750 IC50 2.7 nM
CCN1CCCC(CCOc2ncc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)C1 CHEMBL3925775 IC50 2.7 nM
CCN1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4CCOC)cc2C(F)(F)F)CC1 CHEMBL3949979 IC50 2.7 nM
Cn1cnc2c(-c3ccc(OCCC4CCN(CC#N)CC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3971546 IC50 2.7 nM
Cn1ccc2c(-c3cnc(OCCC4CCCNC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3974360 IC50 2.7 nM
CN1CCC[C@H]1C(=O)N1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ncn4CC3CCOC3)cc2C(F)(F)F)CC1 CHEMBL3961334 IC50 2.7 nM
CCN1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4CC3CCOC3)cc2C#N)CC1 CHEMBL3896371 IC50 2.7 nM
CN1CCC(C(=O)N2CCC(CCOc3ccc(-c4nc(C#N)nc5c4ncn5C)cc3C(F)(F)F)CC2)CC1 CHEMBL3962978 IC50 2.7 nM
Cn1cnc2c(-c3cnc(OCCC4CCN(C(=O)C5CCCN5)CC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3892435 IC50 2.7 nM
CN1CCC[C@H]1C(=O)N1CCC(OCCOc2ncc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)CC1 CHEMBL3912219 IC50 2.7 nM
Cn1ccc2c(-c3cnc(OCC4CCN(C(=O)C5CCNCC5)CC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3916347 IC50 2.7 nM
CC(C)(C)OC(=O)N1CC(C(=O)N2C[C@H](S(=O)(=O)c3ccc(OCC(F)(F)F)cc3Cl)C[C@H]2C(=O)NC2(C#N)CC2)(c2ccc(Cl)cn2)C1 CHEMBL3671325 IC50 2.749 nM
N#Cc1nc2c(c(N3CC[C@H](S(=O)(=O)c4ccc(-n5cccn5)cc4Cl)C3)n1)CN(C=O)C2 CHEMBL3651523 IC50 2.75 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCCc1cccc2ccccc12 CHEMBL3649411 IC50 2.758 nM
Cc1cccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ncc(Cl)cc4F)CC3)C2)n1 CHEMBL4108812 IC50 2.796 nM
CCC(C)(C)CC[C@H](NC(=O)N1CCOCC1)C(=O)NC1(C#N)CCN(C)CC1 CHEMBL2207559 IC50 2.8 nM
CCOC(=O)N1CCC(N2CCC2C(=O)N2C[C@H](S(=O)(=O)c3ccc(Cl)cc3)C[C@H]2C(=O)NC2(C#N)CC2)CC1 CHEMBL3701867 IC50 2.8 nM
N#Cc1nc(-c2ccc(OCCC3CCNCC3)c(C(F)(F)F)c2)c2ccn(C3CCOC3)c2n1 CHEMBL3972995 IC50 2.8 nM
CCN1CCC(COc2ccc(-c3nc(C#N)nc4c3ccn4CC3CCOC3)cc2C(F)(F)F)CC1 CHEMBL3925375 IC50 2.8 nM
CC(C)CN1CCC(CCOc2ncc(-c3nc(C#N)nc4c3ncn4C)cc2C(F)(F)F)CC1 CHEMBL3890864 IC50 2.8 nM
Cn1ccc2c(-c3cnc(OCCO[C@H]4CCNC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3985616 IC50 2.8 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ncccc3Cl)CN2C(=O)C2(c3ncc(Cl)cc3F)CC2)CC1 CHEMBL4109577 IC50 2.844 nM
CCCCNC(=O)C(=O)[C@H](CC)NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1 CHEMBL3649420 IC50 2.866 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(OCC(F)(F)F)cc2Cl)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649371 IC50 2.876 nM
COc1ccc(NCCNC(=O)[C@H](CC2CCCCC2)NC(=O)c2cccc(-c3ccccc3)c2)cc1 CHEMBL198611 Ki 2.9 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)C(C)C)cc1 CHEMBL482348 Ki 2.9 nM
CCOc1ccc(C(=O)NC(C)C(=O)C(=O)Nc2cc[nH]n2)c(Cl)c1C(F)(F)F CHEMBL1289423 IC50 2.9 nM
CC(C)C[C@H](NC(=O)c1ccco1)C(=O)N[C@H]1CC[C@@H](C)N(S(=O)(=O)c2ccccn2)CC1=O CHEMBL1807649 IC50 2.9 nM
CCOc1ccc(-c2nc(C#N)nc3c2ccn3CC(=O)NC2CCN(C)CC2)cc1C(F)(F)F CHEMBL3889868 IC50 2.9 nM
CN(C)C(=O)CN1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4CC3CCOC3)cc2C(F)(F)F)CC1 CHEMBL3955366 IC50 2.9 nM
CCN1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4C3COC3)cc2C(F)(F)F)CC1 CHEMBL3889502 IC50 2.9 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(OCC(F)(F)F)cc3Cl)CN2C(=O)C2(c3ncc(Cl)cc3F)CNC2)CC1 CHEMBL3671338 IC50 2.917 nM
CCCCNC(=O)C(=O)[C@H](CCC)NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1 CHEMBL3649421 IC50 2.934 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ncc(Br)cc2F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649384 IC50 2.978 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(F)cc2C(F)(F)F)CN1c1cc(C)nn1C1CCC1)C(=O)C(=O)NC1CC1 CHEMBL3649365 IC50 2.979 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(Cl)cn3)CN2C(=O)C2(c3ncc(Cl)cc3F)CC2)CC1 CHEMBL4108354 IC50 2.996 nM
Cc1ccccc1COC[C@@H](C#N)NC(=O)[C@H](CC(C)C)NC(=O)N1CCOCC1 CHEMBL346448 Kd 3.0 nM
O=C(N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H]1C(=O)N2CCS(=O)(=O)[C@@H]12)OCc1ccccc1 CHEMBL323638 IC50 3.0 nM
C[C@@H](CN1CC(C)(C)c2cc(F)ccc21)NC(=O)[C@H](CC1CCCCC1)Nc1nc2cccc(Cl)c2o1 CHEMBL381186 Ki 3.0 nM
COc1ccc(NCCNC(=O)[C@H](CC2CCCCC2)NC(=O)c2ccc(-c3cccc(C(F)(F)F)c3)o2)cc1 CHEMBL198450 Ki 3.0 nM
CN1CCC(Oc2ccc(NC(=O)c3cnc(C#N)nc3NCC3CCC4(CC3)CC4)c(-c3ccccc3)c2)CC1 CHEMBL443161 IC50 3.0 nM
CNC(=O)c1c(NCC2CCC3(CCC3)CC2)nc(C#N)nc1OCC1CCN(C)CC1 CHEMBL515025 IC50 3.0 nM
CNC(=O)c1c(NCC2CCC3(CCC3)CC2)nc(C#N)nc1OCC1CCN(C(C)C)CC1 CHEMBL478013 IC50 3.0 nM
CNC(=O)c1c(NCC2CCC3(CCC3)CC2)nc(C#N)nc1OCC1CCN(CCO)CC1 CHEMBL514042 IC50 3.0 nM
CC(CN1CC(C)(C)c2cc(F)ccc21)NC(=O)C(CC1CCCCC1)Nc1nc2ccccc2o1 CHEMBL491564 Activity 3.0 nM
CCC(NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2)CN1C(=O)c1ccccc1)C(=O)c1nc2ccccc2o1 CHEMBL2380716 IC50 3.0 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3)C[C@H]2C(=O)N2CC3(COC3)C2)CC1 CHEMBL3093824 IC50 3.0 nM
CC(C)(C#N)NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2)C[C@H]1C(=O)N1CCOCC1 CHEMBL3093946 IC50 3.0 nM
CCn1ccc2c(-c3ccc(OCCC4CCNCC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3986572 IC50 3.0 nM
CCN1CCCC(COc2ccc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)C1 CHEMBL3905182 IC50 3.0 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NCCc1ccc2ccccc2c1 CHEMBL3639482 IC50 3.076 nM
O=C(N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H]1CCCN(S(=O)(=O)c2ccccn2)CC1=O)c1cc2ccccc2o1 CHEMBL194861 Ki app 3.1 nM
CN1CCN(c2ccc(CCNC(=O)c3cnc(C#N)nc3NCC(C)(C)C)cc2)CC1 CHEMBL220760 IC50 3.1 nM
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cc(OC)ccc1[N+](=O)[O-] CHEMBL1085726 IC50 3.1 nM
CC(=O)Nc1ccc(C(=O)N[C@H](c2cn(C3(C#N)CC3)nn2)C2CCCCC2)cc1 CHEMBL2207592 IC50 3.1 nM
CCC(=O)N1C[C@H](S(=O)(=O)c2ccccc2)C[C@H]1C(=O)NC(CC)C(=O)c1nc2ccccc2o1 CHEMBL2380717 IC50 3.1 nM
CN1CCC[C@H]1C(=O)N1CCC(CCOc2ncc(-c3nc(C#N)nc4c3ncn4C)cc2C(F)(F)F)CC1 CHEMBL3908547 IC50 3.1 nM
N#Cc1nc(-c2ccc(OCCC3CCN(CCO)CC3)c(C(F)(F)F)c2)c2ccn(CC3CCOC3)c2n1 CHEMBL3895203 IC50 3.1 nM
Cn1ccc2c(-c3ccc(OCC4CCCNC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3962553 IC50 3.1 nM
CCN1CC(COc2ccc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)C1 CHEMBL3901848 IC50 3.1 nM
N#Cc1nc(-c2cnc(OCCC3CCNCC3)c(C(F)(F)F)c2)c2ccn(CC(=O)N3CCOCC3)c2n1 CHEMBL3900851 IC50 3.1 nM
N#Cc1ncc(C(=O)NCC(F)(F)F)c(N2CC[C@H](S(=O)(=O)c3ccc(F)cc3Cl)C2)n1 CHEMBL3651524 IC50 3.15 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(OCC(F)(F)F)cc3Cl)CN2C(=O)C2(c3ccc(Cl)cn3)CNC2)CC1 CHEMBL3671327 IC50 3.158 nM
N#CC1(n2cc([C@@H](NC(=O)c3cccs3)C3CCCCC3)nn2)CC1 CHEMBL2207156 IC50 3.2 nM
CCC(NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(-n3cccn3)cc2)CN1C(C)=O)C(=O)c1nc2ccccc2o1 CHEMBL2380729 IC50 3.2 nM
CCC(NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(F)cc2)CN1C(C)=O)C(=O)c1nc2ccccc2o1 CHEMBL2380728 IC50 3.2 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CCCCC2)CC1)C(=O)NC1(C#N)CC1 CHEMBL3640731 Ki 3.2 nM
N#Cc1nccc(N2C[C@@H](S(=O)(=O)c3ccccc3C(F)(F)F)C[C@@H]2CO)n1 CHEMBL3651525 IC50 3.2 nM
CCN1CCC(CCOc2ncc(-c3nc(C#N)nc4c3ccn4CC3CCOCC3)cc2C(F)(F)F)CC1 CHEMBL3970149 IC50 3.2 nM
N#Cc1nc(-c2ccc(OCCC3CCN(CCO)CC3)c(C(F)(F)F)c2)c2ccn(CC3CCCO3)c2n1 CHEMBL3986814 IC50 3.2 nM
Cn1cnc2c(-c3cnc(OCCC4CCN(C(C)(C)C)CC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3923653 IC50 3.2 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ncccc3C(F)(F)F)CN2C(=O)C2(c3ncc(Cl)cc3F)CC2)CC1 CHEMBL4113446 IC50 3.213 nM
COc1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ccc(Cl)cn4)CN(C(=O)OC(C)(C)C)C3)C2)c(Cl)c1 CHEMBL3671322 IC50 3.223 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2ccc(OC)cc2)cc1 CHEMBL475269 Ki 3.3 nM
Cc1noc(C)c1CN1CCC(CCOc2ccc(-c3cc4c(ncn4C)c(C#N)n3)cc2C(F)(F)F)CC1 CHEMBL1669277 IC50 3.3 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2)CN1C(C)=O)C(=O)c1nc2ccccc2o1 CHEMBL2380735 IC50 3.3 nM
CCC(NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2)CN1C(=O)c1ccncc1)C(=O)c1nc2ccccc2o1 CHEMBL2380723 IC50 3.3 nM
CCC(NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2)CN1C(=O)CCOC)C(=O)c1nc2ccccc2o1 CHEMBL2380721 IC50 3.3 nM
CCC(NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2)CN1C(=O)C1CCCCC1)C(=O)c1nc2ccccc2o1 CHEMBL2380719 IC50 3.3 nM
CCC(NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2)CN1C(C)=O)C(=O)c1nc2ccccc2o1 CHEMBL2380618 IC50 3.3 nM
CN(C)CCCOc1ccc(-c2cc3c(nnn3C)c(C#N)n2)cc1C(F)(F)F CHEMBL3669128 IC50 3.3 nM
Cn1c(C(F)(F)F)nc2c(-c3cnc(OCCC4CCNCC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3897588 IC50 3.3 nM
N#Cc1nc(-c2ccc(OCCC3CCNCC3)c(C#N)c2)c2ccn(CC3CCOC3)c2n1 CHEMBL3929854 IC50 3.3 nM
CN1CCC[C@H]1C(=O)N1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4C3COC3)cc2C(F)(F)F)CC1 CHEMBL3913986 IC50 3.3 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(N3CCOCC3)cc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649417 IC50 3.328 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2cccc(F)c2)cc1 CHEMBL474865 Ki 3.4 nM
CCCCS(=O)(=O)Nc1ccc(C(=O)N[C@@H](CC2(C)CCCC2)C(=O)N[C@@H]2C(=O)CO[C@H]2CC)cc1 CHEMBL519115 Ki 3.4 nM
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)C1(C)CC1 CHEMBL1083930 IC50 3.4 nM
CN1CCC[C@@H]1C(=O)N1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ncn4C)cc2C(F)(F)F)CC1 CHEMBL4113999 IC50 3.4 nM
CN1CCC[C@H]1C(=O)N1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4CC3CCCO3)cc2C(F)(F)F)CC1 CHEMBL3941216 IC50 3.4 nM
N#Cc1nc(-c2cnc(OCCC3CCNCC3)c(C(F)(F)F)c2)c2ccn(CC3CCOC3)c2n1 CHEMBL3912436 IC50 3.4 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](Sc3cc(C(F)(F)F)ccc3Cl)CN2C(=O)C2(c3ncc(Cl)cc3F)CC2)CC1 CHEMBL4109836 IC50 3.466 nM
C[C@H](Oc1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ncc(Br)cc4F)CNC3)C2)c(Cl)c1)C(F)(F)F CHEMBL3671346 IC50 3.478 nM
CS(=O)(=O)Nc1ccc(C(=O)N[C@H](c2cn(C3(C#N)CC3)nn2)C2CCCCC2)cc1 CHEMBL2207593 IC50 3.5 nM
CCC(NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2)CN1C(=O)c1cccnc1)C(=O)c1nc2ccccc2o1 CHEMBL2380616 IC50 3.5 nM
CCC(NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2)CN1S(C)(=O)=O)C(=O)c1nc2ccccc2o1 CHEMBL2380619 IC50 3.5 nM
CN1CCC[C@H]1C(=O)N1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ncn4C)cc2C(F)(F)F)CC1 CHEMBL3903038 IC50 3.5 nM
N#Cc1nc(-c2cnc(OCCC3CCNCC3)c(C(F)(F)F)c2)c2ccn(CC3CCOCC3)c2n1 CHEMBL3973415 IC50 3.5 nM
C[C@H](Oc1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ncc(Br)cc4F)CN(C(=O)OC(C)(C)C)C3)C2)c(Cl)c1)C(F)(F)F CHEMBL3671345 IC50 3.542 nM
N#Cc1ncc(C(=O)NCC(F)(F)F)c(N2CC[C@H](S(=O)(=O)c3ccc(N4CCN(C5CC5)CC4)cc3Cl)C2)n1 CHEMBL3651526 IC50 3.55 nM
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cc(SC)ccc1Cl CHEMBL1083919 IC50 3.6 nM
O=C(N[C@H](C(=O)N1C[C@H](Cl)[C@H]2OCC(=O)[C@H]21)C1CCCCC1)c1cccc(-n2cnnn2)c1 CHEMBL3648405 Ki 3.6 nM
N#Cc1nccc(N2C[C@@H](S(=O)(=O)c3ccccc3C(F)(F)F)C[C@@H]2CN2CCC(F)(F)C2)n1 CHEMBL3651479 IC50 3.6 nM
Cn1ccc2c(-c3ccc(OCCC4CC5CCC(C4)N5)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3912252 IC50 3.6 nM
Cn1ccc2c(-c3ccc(OCC4(C)CCNCC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3926834 IC50 3.6 nM
CN1CCC[C@H]1C(=O)N1CCCC(COc2ccc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)C1 CHEMBL3919688 IC50 3.6 nM
N#C[C@]1(NC(=O)[C@@H](CC(=O)N2CCOCC2)CC2CCCCC2)CCN(Cc2ccccc2)C1 CHEMBL234694 Kd 3.64 nM
CC(C)(C)OC(=O)N1CC(C(=O)N2C[C@H](S(=O)(=O)c3ccc(OCC(F)(F)F)cc3Cl)C[C@H]2C(=O)NC2(C#N)CC2)(c2ccc(Br)cn2)C1 CHEMBL3671326 IC50 3.687 nM
CCC(NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2)CN1C(=O)N1CCCC1)C(=O)c1nc2ccccc2o1 CHEMBL2380722 IC50 3.7 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2(N3CCN(C(=O)C(F)(F)F)CC3)CC2)CC1 CHEMBL3701880 IC50 3.7 nM
CCN1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4CC)cc2C(F)(F)F)CC1 CHEMBL3977959 IC50 3.7 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1C(=O)C1(C(F)(F)F)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649368 IC50 3.783 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2ccccc2F)cc1 CHEMBL515588 Ki 3.8 nM
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)/C=C/c1cc(OC)ccc1OC CHEMBL1085729 IC50 3.8 nM
CC1(C)CCC(N2CCC2C(=O)N2C[C@H](S(=O)(=O)c3ccccc3Cl)C[C@H]2C(=O)NC2(C#N)CC2)CC1 CHEMBL3701848 IC50 3.8 nM
CCOc1ccc(-c2nc(C#N)nc3c2ncn3C)cc1C(F)(F)F CHEMBL3895692 IC50 3.8 nM
CCN1CCC(C)(COc2ccc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)CC1 CHEMBL3901954 IC50 3.8 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(OCC(F)(F)F)cc3Cl)CN2C(=O)C2(c3ccc(Br)cn3)CNC2)CC1 CHEMBL3671328 IC50 3.823 nM
C[C@H](Oc1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ncc(Cl)cc4F)CCN3)C2)c(Cl)c1)C(F)(F)F CHEMBL3671347 IC50 3.826 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2ccccc2C)cc1 CHEMBL475063 Ki 3.9 nM
CCOc1ccc(-c2nc(C#N)c3nc[nH]c3n2)cc1C(F)(F)F CHEMBL1209531 IC50 3.9 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2CCN2C2CCN(CC(F)(F)F)CC2)CC1 CHEMBL3701852 IC50 3.9 nM
CCN1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4CC3CCOC3)cc2C(F)(F)F)CC1 CHEMBL3925670 IC50 3.9 nM
CC(C)C[C@H](NC(=O)N1CCOCC1)C(=O)N[C@H](C#N)c1ccccc1 CHEMBL347745 Kd 4.0 nM
CC(C)(C#N)NC(=O)[C@H](CC1CCCCC1)NC(=O)N1CCOCC1 CHEMBL150358 Kd 4.0 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@H]1CCCN(S(=O)(=O)c2ccccn2)CC1=O CHEMBL286364 Ki 4.0 nM
COc1ccc(NCCNC(=O)[C@H](CC2CCCCC2)NC(=O)c2ccc(N3CCOCC3)cc2)cc1 CHEMBL198494 Ki 4.0 nM
N#Cc1ncc(C(=O)N[C@H](Cc2ccccn2)CN2CCCC2)c(NCC2CCC3(CC2)CC3)n1 CHEMBL455913 IC50 4.0 nM
CC(=O)N1CCN(c2ccc(OCc3cc4cnc(C#N)nc4n3CCC3CCC(F)(F)CC3)cc2)CC1 CHEMBL461619 Ki 4.0 nM
CNC(=O)c1c(NCC2CCC3(CCC3)CC2)nc(C#N)nc1OCCC1CCN(C)CC1 CHEMBL478011 IC50 4.0 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2ccccc2)c(C)c1 CHEMBL473654 Ki 4.0 nM
C[C@@](NCc1ccccc1)(c1cn(C2(C#N)CC2)nn1)C1CCCCC1 CHEMBL2207153 IC50 4.0 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3)C[C@H]2C(=O)N2CCS(=O)(=O)CC2)CC1 CHEMBL3093926 IC50 4.0 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3)C[C@H]2C(=O)N2CCOCC2)CCC1 CHEMBL3093948 IC50 4.0 nM
N#Cc1nccc(N2C[C@@H](S(=O)(=O)c3ccccc3C(F)(F)F)C[C@@H]2CN2CCOCC2)n1 CHEMBL3651477 IC50 4.0 nM
N#Cc1ncc(C(=O)NCC(F)(F)F)c(N2CC[C@H](S(=O)(=O)c3ccc(OCC(F)(F)F)cc3Cl)C2)n1 CHEMBL3651527 IC50 4.0 nM
CN(C)C(=O)CN1CCCC(COc2ccc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)C1 CHEMBL3981661 IC50 4.0 nM
CC(C)C[C@H](NS(=O)(=O)c1cccc(-c2ccccc2)c1)C(=O)NC1(C#N)CC1 CHEMBL4763197 Ki 4.02 nM
CCC(NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2)CN1C(=O)c1ccc(-c2ccccc2)cc1)C(=O)c1nc2ccccc2o1 CHEMBL2380726 IC50 4.1 nM
CCOC(=O)N1CCC(N2CCC2C(=O)N2C[C@H](S(=O)(=O)c3ccccc3OC(F)(F)F)C[C@H]2C(=O)NC2(C#N)CC2)CC1 CHEMBL3701868 IC50 4.1 nM
N#CC1(n2cc([C@@H](NC(=O)c3ccoc3)C3CCCCC3)nn2)CC1 CHEMBL2207585 IC50 4.2 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2(N3CCNCC3)CC2)CC1 CHEMBL3701875 IC50 4.2 nM
CCOc1ccc(-c2nc(C#N)nc3c2ccn3CC(=O)N2CCN(C)CC2)cc1C(F)(F)F CHEMBL3944478 IC50 4.2 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccn3)CN2C(=O)C2(c3ncc(Cl)cc3F)CC2)CC1 CHEMBL4112764 IC50 4.24 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3-n3ccnn3)CN2C(=O)C2(c3ncc(Cl)cc3F)CC2)CC1 CHEMBL4108180 IC50 4.268 nM
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)C1=CC(=O)CC(C)(C)O1 CHEMBL1085966 IC50 4.3 nM
CC[C@@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2)CN1C(C)=O)C(=O)c1nc2ccccc2o1 CHEMBL2380736 IC50 4.3 nM
CC(C)N1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4CC3CCOC3)cc2C#N)CC1 CHEMBL3949781 IC50 4.3 nM
CN1CCN(c2ccc(S(=O)(=O)[C@H]3CCN(c4nccc(C#N)n4)C3)c(Cl)c2)CC1 CHEMBL3651528 IC50 4.372 nM
N#C[C@H](COCc1ccccc1)NC(=O)[C@@H](CC(=O)N1CCOCC1)CC1CCCCC1 CHEMBL393166 Kd 4.39 nM
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)N1CCOCC1 CHEMBL1083318 IC50 4.4 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2nccn2C)cc1 CHEMBL519136 Ki 4.5 nM
N#Cc1nccc(-c2ccc(OCCCO)c(C(F)(F)F)c2)n1 CHEMBL1210690 IC50 4.5 nM
CCOc1ccc(-c2nc(C#N)c3ncn(CCO)c3n2)cc1C(F)(F)F CHEMBL1209533 IC50 4.5 nM
Cn1ccc2c(-c3ccc(OCCC4C5CCC4CNC5)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3943694 IC50 4.5 nM
Cn1ccc2c(-c3ccc(OCC4CNC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3893553 IC50 4.5 nM
Cc1cc(-c2ccc(S(=O)(=O)[C@@H]3C[C@@H](C(=O)NC4(C#N)CC4)N(C(=O)C4(c5ncc(Br)cc5F)CCN4C(=O)OC(C)(C)C)C3)c(Cl)c2)ccn1 CHEMBL3671351 IC50 4.597 nM
O=C(N[C@@H](Cc1cccs1)C(=O)N[C@@H]1C(=O)N2CCS(=O)(=O)[C@@H]12)OCc1ccccc1 CHEMBL113706 IC50 4.6 nM
N#CC1(n2cc([C@@H](NC(=O)c3cnco3)C3CCCCC3)nn2)CC1 CHEMBL2207586 IC50 4.6 nM
CN(C)C(=O)CN1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4CC3CCCO3)cc2C(F)(F)F)CC1 CHEMBL3896488 IC50 4.7 nM
CN1CCC[C@H]1C(=O)N1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4CC3CCOC3)cc2C(F)(F)F)CC1 CHEMBL3900039 IC50 4.7 nM
CC(NC(=O)c1ccc(OCc2ccccn2)c(C(F)(F)F)c1Cl)C(=O)C(N)=O CHEMBL1289535 IC50 4.8 nM
CN1CCC[C@H]1C(=O)N1CCC(CCOc2ncc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)CC1 CHEMBL3917872 IC50 4.8 nM
N#C[C@H](COCc1ccc(Cl)cc1)NC(=O)[C@@H](CC(=O)N1CCOCC1)CC1CCCCC1 CHEMBL231883 Kd 4.86 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(C)(=O)=O)c(C)c1 CHEMBL479461 Ki 4.9 nM
C[C@@H]1CC[C@H](NC(=O)[C@H](CC2=CCCC2)NC(=O)c2ccco2)C(=O)CN1S(=O)(=O)c1ccccn1 CHEMBL1807645 IC50 4.9 nM
N#CC1(n2cc([C@@H](NC(=O)c3ccc(F)cc3)C3CCCCC3)nn2)CC1 CHEMBL2207157 IC50 4.9 nM
CC(C)NC(=O)[C@@H]1C[C@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1c1ccnc(C#N)n1 CHEMBL3651488 IC50 4.967 nM
N#C[C@H](CCc1ccccc1)NC(=O)[C@@H](NC(=O)N1CCOCC1)C1CCCCC1 CHEMBL345502 Kd 5.0 nM
OC(CN1CCN(c2ccccc2)CC1)Cn1nc(-c2ccccc2)c2c1CCNC2 CHEMBL363669 IC50 5.0 nM
COc1ccc(NCCNC(=O)[C@H](CC2CCCCC2)NC(=O)c2ccc3ccccc3c2)cc1 CHEMBL264519 Ki 5.0 nM
O=C(N[C@@H](COCc1ccccc1)CN1CCc2cc(F)ccc21)[C@H](CC1CCCCC1)Nc1nc2ccccc2o1 CHEMBL380756 Ki 5.0 nM
CS(=O)(=O)CC[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)N1CCOCC1 CHEMBL379079 Ki 5.0 nM
CS(=O)(=O)CC[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)[C@@H](CC(=O)N1CCOCC1)CC1CCCCC1 CHEMBL241467 Ki 5.0 nM
N#CC1(NC(=O)[C@H](CS(=O)(=O)c2nccs2)N[C@@H](c2ccccc2)C(F)(F)F)CC1 CHEMBL400972 IC50 5.0 nM
CC(=O)N1CCN(c2ccc(OCc3cc4cnc(C#N)nc4n3CCC3CCCC3)cc2)CC1 CHEMBL462278 IC50 5.0 nM
CNC(=O)c1c(NCC2CCC3(CCC3)CC2)nc(C#N)nc1OCC1CCNCC1 CHEMBL476130 IC50 5.0 nM
CNC(=O)c1c(NCC2CCC3(CCC3)CC2)nc(C#N)nc1OC1CC(C)(C)NC(C)(C)C1 CHEMBL478224 IC50 5.0 nM
CS(=O)(=O)CCC(CNc1ccc(OC(F)(F)F)cc1)NC(=O)C(CC(=O)N1CCOCC1)CC1CCCCC1 CHEMBL493231 Activity 5.0 nM
C[C@H]1CC[C@H]([C@H](NC(=O)c2ccccc2)C(=O)N2C[C@H](Cl)[C@H]3OCC(=O)[C@H]32)CC1 CHEMBL3648401 Ki 5.0 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CC1)CC2)C(=O)NC1(C#N)CC1 CHEMBL3640715 Ki 5.0 nM
COCCN1CCN(c2ccc(S(=O)(=O)[C@H]3CCN(c4nccc(C#N)n4)C3)c(Cl)c2)CC1 CHEMBL3651529 IC50 5.068 nM
CCCC[C@H](NC(=O)OCC1(Cc2ccc(F)cc2)CCC1)C(=O)C(=O)Nc1ccn[nH]1 CHEMBL185097 IC50 5.2 nM
N#CC1(n2cc([C@@H](NC(=O)N3CCOCC3)C3CCCCC3)nn2)CC1 CHEMBL2207151 IC50 5.2 nM
N#CCNC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccccc1 CHEMBL200884 IC50 5.3 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)N(C)C)cc1 CHEMBL521115 Ki 5.3 nM
N#Cc1nccc(N2CC[C@H](S(=O)(=O)c3cccc(Cl)c3Cl)C2)n1 CHEMBL3651480 IC50 5.35 nM
COc1cccc(C(=O)N[C@H](c2cn(C3(C#N)CC3)nn2)C2CCCCC2)c1 CHEMBL2207158 IC50 5.4 nM
CC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(O[C@@H](C)C(F)(F)F)cc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649406 IC50 5.426 nM
C[C@H](Oc1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)NC3(C#N)CC3)N(C(=O)C3(c4ncc(Br)cc4F)CCN3)C2)c(Cl)c1)C(F)(F)F CHEMBL3671348 IC50 5.455 nM
CCC[C@H](N)C(=O)N[C@H](/C=C/S(=O)(=O)c1ccccc1)CCc1ccccc1 CHEMBL514348 Ki 5.5 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(C)(=O)=O)c(Cl)c1 CHEMBL519135 Ki 5.6 nM
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cccc(C)c1[N+](=O)[O-] CHEMBL1085974 IC50 5.6 nM
N#CC1(n2cc([C@@H](NC(=O)c3ccco3)C3CCCCC3)nn2)CC1 CHEMBL2203326 IC50 5.6 nM
N#Cc1nccc(N2CC[C@H](S(=O)(=O)c3cccc(C(F)(F)F)c3)C2)n1 CHEMBL3651482 IC50 5.6 nM
CC(C)C[C@H](NC(=O)c1cccc2ccccc12)C(=O)N[C@H]1CCCN(S(=O)(=O)c2ccccn2)CC1=O CHEMBL382286 Ki app 5.7 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2nc(C(C)C)cs2)cc1 CHEMBL474257 Ki 5.7 nM
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)Cc1cccc2ccccc12 CHEMBL1085982 IC50 5.7 nM
N#CC1(n2cc([C@@H](NC(=O)c3cccc(Cl)c3)C3CCCCC3)nn2)CC1 CHEMBL2207159 IC50 5.7 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@H]1C[C@H](C)CN(S(=O)(=O)c2ccccn2)CC1=O CHEMBL205172 Ki app 5.8 nM
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccc(C(=O)OC)c(N)c1 CHEMBL1085969 IC50 5.8 nM
CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)N/C=C/S(=O)(=O)c1ccccc1)C(=O)NC(=O)NN1CCOCC1 CHEMBL3142832 Ki 5.9 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2cccnc2Cl)cc1 CHEMBL515251 Ki 5.9 nM
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cccc(F)c1F CHEMBL1085976 IC50 5.9 nM
Cc1cc(C(=O)N[C@H](c2cn(C3(C#N)CC3)nn2)C2CCCCC2)cs1 CHEMBL2207160 IC50 5.9 nM
CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(O[C@@H](C)C(F)(F)F)cc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1 CHEMBL3649407 IC50 5.982 nM
COc1cccc(C(=O)N[C@@H](CC(C)(C)C)C(=O)N[C@@H](CC(=O)O)CN2CCc3cc(F)ccc32)c1 CHEMBL1162922 Ki 6.0 nM
O=C(N[C@@H](CC1CCCCC1)C(=O)NCCNc1ccc(OC(F)(F)F)cc1)c1ccoc1 CHEMBL215402 Ki 6.0 nM
CN1CCC(CNC(=O)c2cnc(C#N)nc2NCC2CCC3(CC2)CC3)(c2ccccc2)CC1 CHEMBL508319 IC50 6.0 nM
N#Cc1ncc2cc(COc3cccc(CCC(=O)O)c3)n(CCC3CCCCC3)c2n1 CHEMBL482268 IC50 6.0 nM
N#Cc1ncc2cc(CSc3ccncc3)n(CCC3CCCCC3)c2n1 CHEMBL493246 IC50 6.0 nM
CNC(=O)c1c(NCC2CCC3(CCC3)CC2)nc(C#N)nc1OCCO CHEMBL477600 IC50 6.0 nM
CCCc1cc(-c2ccc(OCC)c(C(F)(F)F)c2)nc(C#N)n1 CHEMBL1209450 IC50 6.0 nM
CN(C)C(=O)[C@@H]1C[C@H](S(=O)(=O)c2ccccc2)C[C@H]1C(=O)NC1(C#N)CC1 CHEMBL3093931 IC50 6.0 nM
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cncc(C)n1 CHEMBL1085980 IC50 6.1 nM
Cn1cnc2c(-c3ccc(OCCC4CCN(C(=O)CO)CC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3933647 IC50 6.1 nM
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccc(C)cc1 CHEMBL1085975 IC50 6.2 nM
CCOC(=O)CNC(=O)C(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cc(Br)ccc1N CHEMBL1085979 IC50 6.2 nM
CCN1CCN(C2(C(=O)N3C[C@H](S(=O)(=O)c4ccccc4Cl)C[C@H]3C(=O)NC3(C#N)CC3)CC2)CC1 CHEMBL3701881 IC50 6.2 nM
CN(C)C(=O)N1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ncn4C)cc2C(F)(F)F)CC1 CHEMBL3904221 IC50 6.2 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(C(F)(F)F)cn3)CN2C(=O)C2(c3ncc(Cl)cc3F)CC2)CC1 CHEMBL4107039 IC50 6.244 nM
CS(=O)(=O)C[C@H](N[C@@H](c1cccc(F)c1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL250121 IC50 6.4 nM
O=C(N[C@H](C(=O)c1nc2ccccc2o1)C1CC1)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 CHEMBL256191 IC50 6.6 nM
CCOC(=O)CNC(=O)C(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)C(=O)c1cccs1 CHEMBL1085730 IC50 6.6 nM
CCOC(=O)N1CCC(N2CCC2C(=O)N2C[C@H](Sc3ccc(F)cc3Cl)C[C@H]2C(=O)NC2(C#N)CC2)CC1 CHEMBL3701858 IC50 6.7 nM
CCOc1ccc(-c2nc(C#N)c3ncn(CCCN(C)C)c3n2)cc1C(F)(F)F CHEMBL1209534 IC50 6.9 nM
CC(C)C[C@H](NC(=O)N1CCOCC1)C(=O)N[C@H](C#N)CCc1ccccc1 CHEMBL153678 Kd 7.0 nM
CC(C)C[C@H](NC(=O)N1CCOCC1)C(=O)N[C@H](C#N)Cc1ccc(Cl)c(Cl)c1 CHEMBL153319 Kd 7.0 nM
COc1cccc(C(=O)N[C@@H](CCC2CCCCC2)C(=O)N[C@@H](CCN2CCOCC2)CN2CCc3cc(F)ccc32)c1 CHEMBL203052 Ki 7.0 nM
CC(C)C[C@H](N[C@@H](c1ccc(-c2ccc(N3CCNCC3)cc2)cc1)C(F)(F)F)C(=O)NCC#N CHEMBL195454 IC50 7.0 nM
CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(=O)O)C(=O)NCCCCN=C(N)N CHEMBL374508 IC50 7.0 nM
CN1CCC(NC(=O)c2cnc(C#N)nc2NCC2CCC3(CC2)CC3)(c2ccccc2)CC1 CHEMBL456134 IC50 7.0 nM
N#Cc1ncc2cc(COc3cccc(C(N)=O)c3)n(CCC3CCCCC3)c2n1 CHEMBL482269 IC50 7.0 nM
N#Cc1ncc2cc(Cc3ccc(Cl)cc3)n(CCC3CCCC3)c2n1 CHEMBL523501 IC50 7.0 nM
CS(=O)(=O)N1CCc2c(c(-c3ccc(C(F)(F)F)c(SCC(=O)N4CC[C@@H](O)C4)c3)nn2CC(O)CN2CCC(c3ccccn3)CC2)C1 CHEMBL1090994 IC50 7.0 nM
CS(=O)(=O)N1CCc2c(c(-c3ccc(C(F)(F)F)c(SCC(=O)N4CC[C@H](O)C4)c3)nn2CC(O)CN2CCC(c3ccccn3)CC2)C1 CHEMBL1090990 IC50 7.0 nM
N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3)C[C@H]2C(=O)N2CC(O)C2)CC1 CHEMBL3093930 IC50 7.0 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CCCCC2)C1)C(=O)NC1(C#N)CC1 CHEMBL3640719 Ki 7.0 nM
N#Cc1nccc(N2C[C@@H](S(=O)(=O)c3ccccc3C(F)(F)F)C[C@H]2C(=O)N2CCC(F)(F)C2)n1 CHEMBL3639503 IC50 7.0 nM
COc1ccc(NCCNC(=O)[C@H](CC2CCCCC2)NC(=O)c2ccc(-c3ccc(Cl)cc3)o2)cc1 CHEMBL372972 Ki 7.1 nM
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cc2ccccc2n1C CHEMBL1085983 IC50 7.1 nM
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)Cc1cccs1 CHEMBL1083923 IC50 7.2 nM
CCN1CCN(CCCOc2ccc(-c3cc4c(ncn4C)c(C#N)n3)cc2C(F)(F)F)CC1 CHEMBL1209145 IC50 7.2 nM
CCOc1ccc(-c2nc(C#N)c3ncn(CC)c3n2)cc1C(F)(F)F CHEMBL1209532 IC50 7.2 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CC1)CCN(C1CC1)CC2)C(=O)NC1(C#N)CC1 CHEMBL3640714 Ki 7.2 nM
COc1ccc(NCCNC(=O)[C@H](CC2CCCCC2)NC(=O)c2ccc(-c3cccc(Cl)c3)cc2)cc1 CHEMBL198438 Ki 7.4 nM
CNC(=O)O[C@H]1COc2ccc(N3CCN(C4COC4)CC3)cc2[C@@H]1NC(=O)c1ccc(F)cc1 CHEMBL3342553 IC50 7.7 nM
Cn1cnc2c(C#N)nc(-c3ccc(OCCN4CCNC(=O)C4)c(C(F)(F)F)c3)cc21 CHEMBL1209085 IC50 7.8 nM
Cn1cnc2c(C#N)nc(-c3ccc(OCCN4CCCC4=O)c(C(F)(F)F)c3)cc21 CHEMBL1209034 IC50 7.8 nM
Cc1nnc([C@H]2C[C@H](S(=O)(=O)c3ccccc3Cl)CN2c2ccnc(C#N)n2)o1 CHEMBL3651472 IC50 7.8 nM
CN1CCC[C@H]1C(=O)N1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4CC3CCOC3)cc2C#N)CC1 CHEMBL3916383 IC50 7.8 nM
C[C@H](NC(=O)O[C@H](Cn1cnc2cc(Cl)c(Cl)cc21)C(C)(C)C)C(=O)CNS(=O)(=O)c1ccccn1 CHEMBL232712 IC50 7.9 nM
CN1CCC(CCOc2ccc(-c3cc4c(ncn4C)c(C#N)n3)cc2C(F)(F)F)CC1 CHEMBL1669275 IC50 7.9 nM
Cn1cnc2c(C#N)nc(-c3ccc(OCCC4CCN(Cc5ncco5)CC4)c(C(F)(F)F)c3)cc21 CHEMBL1669278 IC50 7.9 nM
N#CCNC(=O)[C@H](Cc1cccc(-c2cccnn2)c1)NC(=O)c1ccccc1 CHEMBL556436 pIC50 7.943 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC1CCN(C(=O)[C@H](CC(C)C)NC(=O)OCc2ccccc2)CC1=O CHEMBL118449 Ki app 8.0 nM
O=C(N[C@@H](Cc1cccc(F)c1)C(=O)N[C@@H]1C(=O)N2CCS(=O)(=O)[C@@H]12)OCc1ccccc1 CHEMBL116041 IC50 8.0 nM
COc1ccc(NCCNC(=O)[C@H](CC2CCCCC2)NC(=O)c2cccc(Oc3ccccc3)c2)cc1 CHEMBL437323 Ki 8.0 nM
COc1cccc(C(=O)N[C@@H](CCC2CCCCC2)C(=O)N[C@H](CN2CCc3cc(F)ccc32)[C@@H](C)O)c1 CHEMBL205566 Ki 8.0 nM
CC(C)[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 CHEMBL214982 Ki 8.0 nM
O=C(N[C@@H](COCc1ccccc1)CN1CCc2cc(F)ccc21)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 CHEMBL214591 Ki 8.0 nM
CC(=O)Nc1ccc(OCc2cc3cnc(C#N)nc3n2CCC2CCCCC2)cc1 CHEMBL520427 IC50 8.0 nM
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cc(Cl)ccc1[N+](=O)[O-] CHEMBL1085727 IC50 8.0 nM
CC(F)(F)C[C@H](NC(=O)N1CC2(CCN(C3CC3)CC2)C1)C(=O)NC1(C#N)CC1 CHEMBL3640723 Ki 8.0 nM
CCOC(=O)N1CCC(N2CCC2C(=O)N2C[C@H](Sc3cccc(C(F)(F)F)c3)C[C@H]2C(=O)NC2(C#N)CC2)CC1 CHEMBL3701863 IC50 8.0 nM
Cn1cnc2c(C#N)nc(-c3ccc(OCCC4CCNCC4)c(C(F)(F)F)c3)cc21 CHEMBL1209037 IC50 8.0 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@@H]1C[C@H](C)CN(S(=O)(=O)c2ccccn2)CC1=O CHEMBL440574 Ki app 8.3 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)C(F)(F)F)cc1 CHEMBL519633 Ki 8.3 nM
CN(C)C(=O)CN1CCC(CCOc2ccc(-c3cc4c(ncn4C)c(C#N)n3)cc2C(F)(F)F)CC1 CHEMBL1669276 IC50 8.3 nM
CC(C)C[C@H](NC(=O)c1cc2cc(OCCN3CCOCC3)ccc2o1)C(=O)N[C@H]1CCCN(C(=O)Cc2cccc(-c3ccccn3)c2)CC1=O CHEMBL284939 Ki(app) 8.3 nM
CC(NC(=O)c1cccc(C(F)(F)F)c1Cl)C(=O)C(=O)Nc1ccn(C)n1 CHEMBL1289304 IC50 8.5 nM
O=C(N[C@H](C(=O)N1C[C@H](Cl)[C@H]2OCC(=O)[C@H]21)C1CCCCC1)c1ccccc1 CHEMBL3648398 Ki 8.5 nM
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(NS(=O)(=O)c2ncc(C)s2)cc1 CHEMBL481986 Ki 8.6 nM
N#CCNC(=O)[C@@H]1C[C@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1c1ccnc(C#N)n1 CHEMBL3651490 IC50 8.733 nM
CCOC(=O)CNC(=O)C(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)c1cccc2c1C(=O)c1ccccc1-2 CHEMBL1085971 IC50 8.8 nM
N#CC1(n2cc([C@@H](NC(=O)c3ccns3)C3CCCCC3)nn2)CC1 CHEMBL2207161 IC50 8.8 nM
N#CC1(n2cc([C@@H](NC(=O)c3cccnc3)C3CCCCC3)nn2)CC1 CHEMBL2207589 IC50 8.8 nM
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCCN(S(=O)(=O)c2ccccn2)CC1=O)c1cc2ccccc2o1 CHEMBL407633 Ki app 8.9 nM
Cn1cnc2c(-c3ccc(OCC(=O)N4CCNCC4)c(C(F)(F)F)c3)nc(C#N)nc21 CHEMBL3983791 IC50 8.9 nM
N#Cc1nc(-c2ccc(OCCC3CCN(C(CF)CF)CC3)c(C#N)c2)c2ccn(CC3CCOC3)c2n1 CHEMBL3923263 IC50 8.9 nM
CCCC[C@H](NC(=O)N1CCOCC1)C(=O)N[C@H](C#N)CCc1ccccc1 CHEMBL150574 Kd 9.0 nM
CCC[C@H](NC(=O)C(CC(C)C)NC(=O)c1ccc(-c2ccc(I)cc2)cc1)C(=O)C=[N+]=[N-] CHEMBL518284 IC50 9.0 nM
CC(=O)N1CCN(c2ccc(OCc3cc4cnc(C#N)nc4n3CCC3CCCCC3)cc2)CC1 CHEMBL481170 IC50 9.0 nM
CC(=O)N1CCN(c2ccc(OCc3cc4cnc(C#N)nc4n3CCC3CCCCC3)cc2F)CC1 CHEMBL493919 IC50 9.0 nM
CCCC[C@@H](C#N)n1cc([C@@](C)(NC(=O)c2ccsc2)[C@H]2CC[C@H](C)CC2)nn1 CHEMBL2207561 IC50 9.0 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CCCc3ccccc32)C1)C(=O)NC1(C#N)CC1 CHEMBL3640721 Ki 9.0 nM
CC(F)(F)C[C@H](NC(=O)N1CCOC12CCCCC2)C(=O)NC1(C#N)CC1 CHEMBL3640722 Ki 9.0 nM
CC(F)(F)C[C@H](NC(=O)N1CCC2(CC1)CC(=O)N(CC1CC1)C2)C(=O)NC1(C#N)CC1 CHEMBL3640724 Ki 9.0 nM
Cc1cccc(N2CCC(CCOc3ccc(-c4cc5c(nnn5C)c(C#N)n4)cc3C(F)(F)F)CC2)n1 CHEMBL3669130 IC50 9.0 nM
COc1ccc(NCCNC(=O)[C@H](CC2CCCCC2)NC(=O)c2ccc(-c3ccccc3)cc2)cc1 CHEMBL198980 Ki 9.1 nM
C[C@H](NC(=O)OCc1ccccc1)C(=O)N(C)N(C)C#N CHEMBL1651241 Ki 9.1 nM
N#Cc1cncc(N2CC[C@H](S(=O)(=O)c3ccc(N4CCN5CCC[C@H]5C4)cc3Cl)C2)n1 CHEMBL3651530 IC50 9.114 nM
CC(=O)O[C@@H]1NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL292513 Ki 9.2 nM
CCOC(=O)N1CCC(N2CCC2C(=O)N2C[C@H](S(=O)(=O)c3ccccc3OC)C[C@H]2C(=O)NC2(C#N)CC2)CC1 CHEMBL3701866 IC50 9.2 nM
COc1ccc(NCCNC(=O)[C@H](CC2CCCCC2)NC(=O)c2cc3cc(Cl)ccc3o2)cc1 CHEMBL198420 Ki 9.4 nM
CN1CCN(CCCOc2ccc(-c3cc4c(ncn4C)c(C#N)n3)cc2C(F)(F)F)CC1 CHEMBL1209144 IC50 9.5 nM
CC(C)Cc1ccc(-c2ccccc2OCC=O)c(F)c1F CHEMBL390945 Ki 9.6 nM
COc1ccc(NCCNC(=O)[C@H](CC2CCCCC2)NC(=O)c2cccc(C)c2)cc1 CHEMBL199242 Ki 9.7 nM