CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@H]1CC[C@@H](C)N(S(=O)(=O)c2ccccn2)CC1=O CHEMBL203665 Ki app 0.063 nM
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@H]1CCCN(S(=O)(=O)c2ccccn2)CC1=O CHEMBL286364 Ki app 1.8 nM
COCc1nnc(-c2cccc(C[C@H](NC(=O)c3cc(C(C)(C)C)nn3C)C(=O)NCC#N)c2)o1 CHEMBL554065 pIC50 1.995 nM
Cc1nnc(-c2cccc(C[C@H](NC(=O)c3cc(C(C)(C)C)nn3C)C(=O)NCC#N)c2)s1 CHEMBL562844 pIC50 3.162 nM
Cn1nc(C(C)(C)C)cc1C(=O)N[C@@H](Cc1cccc(-c2nncs2)c1)C(=O)NCC#N CHEMBL549378 pIC50 6.31 nM
Cc1nnc(-c2cccc(C[C@H](NC(=O)c3cc(C(C)(C)C)nn3C)C(=O)NCC#N)c2)o1 CHEMBL550872 pIC50 6.31 nM
Cn1nc(C(C)(C)C)cc1C(=O)N[C@@H](Cc1cccc(-c2nnc(CO)o2)c1)C(=O)NCC#N CHEMBL549791 pIC50 7.943 nM
CCC(NC(=O)c1ccc(OCc2ccccn2)c(C(F)(F)F)c1Cl)C(=O)C(=O)Nc1ccn(C)n1 CHEMBL1289645 IC50 16.6 nM
Cn1nc(C(C)(C)C)cc1C(=O)N[C@@H](Cc1cccc(-c2nnco2)c1)C(=O)NCC#N CHEMBL562915 pIC50 19.95 nM
N#CCNC(=O)[C@H](Cc1cccc(-c2nncs2)c1)NC(=O)c1ccccc1 CHEMBL559880 pIC50 25.12 nM
CC(C)[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccc(C#N)cc1F CHEMBL1288530 IC50 28.0 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)NCC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL194068 IC50 29.0 nM
CCC(NC(=O)c1cccc(C(F)(F)F)c1Cl)C(=O)C(=O)Nc1cc[nH]n1 CHEMBL1289305 IC50 29.5 nM
CC(NC(=O)c1ccc(OCc2ccccn2)c(C(F)(F)F)c1Cl)C(=O)C(=O)Nc1ccn(C)n1 CHEMBL1289644 IC50 36.3 nM
Cn1nc(C(C)(C)C)cc1C(=O)N[C@@H](Cc1cccc(-c2nnc(CN)o2)c1)C(=O)NCC#N CHEMBL557455 pIC50 39.81 nM
N#CCNC(=O)[C@H](Cc1cccc(-c2cccnn2)c1)NC(=O)c1ccccc1 CHEMBL556436 pIC50 63.1 nM
CC(C)[C@H](N[C@@H](c1ccc(-c2ccc([C@@H](O)C(F)F)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccc(C#N)cc1F CHEMBL1288532 IC50 69.0 nM
CC(C)(C)NC(=O)N[C@H](C(=O)N1C[C@H]2[C@@H]([C@H]1C(=O)NC(CC1CCC1)C(=O)C(N)=O)C2(C)C)C(C)(C)C CHEMBL218394 IC50 75.0 nM
CCCC[C@H](NC(=O)O[C@@H]1C(=O)OCC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL196896 IC50 79.0 nM
CC(C)[C@H](N[C@@H](c1ccc(-c2ccc(C3(C(N)=O)CC3)cc2)cc1)C(F)(F)F)C(=O)N[C@H](C#N)Cc1ccc(C#N)cc1F CHEMBL1288531 IC50 79.0 nM
Cn1nc(C(C)(C)C)cc1C(=O)N[C@@H](Cc1cccc(-c2nnc(CCN)o2)c1)C(=O)NCC#N CHEMBL555122 pIC50 100.0 nM
O=C(N[C@H](C(=O)N1C[C@H](Cl)[C@H]2OCC(=O)[C@H]21)C1CCCCC1)c1ccccc1 CHEMBL3648398 Ki 100.0 nM
CCCC[C@H](NC(=O)O[C@H](Cn1cnc(-c2ccc(C(F)(F)F)cc2)c1)C(C)(C)C)C(=O)C(=O)Nc1ccn[nH]1 CHEMBL191584 IC50 130.0 nM
Cc1cccc(O[C@H]2CCN3C[C@H]2OC3=O)c1C CHEMBL390474 IC50 131.0 nM
CC[C@H](C)[C@@H](C(=O)O[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)/C=C/C(=O)N1C(=O)C=C(OC)[C@@H]1C)N(C)C CHEMBL541700 IC50 140.0 nM
O=C1O[C@@H]2CN1CC[C@@H]2Oc1ccccc1 CHEMBL230474 IC50 158.0 nM
Cn1cc(-c2cccc(C[C@H](NC(=O)c3cc(C(C)(C)C)nn3C)C(=O)NCC#N)c2)cn1 CHEMBL563471 pIC50 158.49 nM
N#CCNC(=O)[C@H](Cc1cccc(-c2nnco2)c1)NC(=O)c1ccccc1 CHEMBL564626 pIC50 158.49 nM
CCCC[C@H](NC(=O)O[C@H](Cn1ccc(-c2ccc(C(F)(F)F)cc2)n1)C(C)(C)C)C(=O)C(=O)Nc1ccn[nH]1 CHEMBL234367 IC50 170.0 nM
O=C(N[C@H](C(=O)N1C[C@H](Cl)[C@H]2OCC(=O)[C@H]21)C1CCCCC1)c1cccc(-n2ccnc2)c1 CHEMBL3648411 Ki 170.0 nM
CCCC[C@H](NC(=O)OC1C2(C)CCC(C2)C1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL193582 IC50 180.0 nM
N#Cc1nc(Nc2cc(F)cc(F)c2)nc(NC2CCCC2)n1 CHEMBL568171 pIC50 181.97 nM
CCCC[C@H](NC(=O)OC1CC2CCC1C2)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL196298 IC50 190.0 nM
N#CCNC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)c1cccc(Cl)c1 CHEMBL551805 pIC50 199.53 nM
Cc1cc(C)cc(C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NCC#N)c1 CHEMBL559238 pIC50 199.53 nM
Cn1nc(C(C)(C)C)cc1C(=O)N[C@@H](Cc1cccc(Cl)c1)C(=O)NCC#N CHEMBL564131 pIC50 199.53 nM
COc1c(OC)c(OC)c2c(c1O)c(=O)c1cccc(O)c1n2C CHEMBL1668599 Ki 200.0 nM
CC(C)C[C@@H](O)C(=O)N1CC2(CC2)C[C@H]1C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(F)(F)F CHEMBL5430978 IC50 200.0 nM
CCn1cnc2c(Nc3cc(F)cc(F)c3)nc(C#N)nc21 CHEMBL567341 pIC50 239.88 nM
O=C(N[C@H](C(=O)N1C[C@H](Cl)[C@H]2OCC(=O)[C@H]21)C1CCCCC1)c1cccc(-n2cnnn2)c1 CHEMBL3648405 Ki 240.0 nM
Cc1nc(C)c(C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NCC#N)s1 CHEMBL551060 pIC50 251.19 nM
CCCC[C@H](NC(=O)O[C@H]1CCc2ccccc21)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL196240 IC50 290.0 nM
CCCC[C@H](NC(=O)O[C@H]1CCCc2ccccc21)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL195963 IC50 340.0 nM
CCCC[C@H](NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)C(=O)N[C@H](C)c1ccccc1 CHEMBL197509 IC50 390.0 nM
N#CCNC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)C1=CCCCC1 CHEMBL561725 pIC50 398.11 nM
Cc1cccc(C[C@H](NC(=O)c2cc(C(C)(C)C)nn2C)C(=O)NCC#N)c1 CHEMBL565079 pIC50 398.11 nM
O=c1c2cc(OCc3ccccc3)ccc2[nH]c2ccc([N+](=O)[O-])cc12 CHEMBL2042470 Ki 400.0 nM
O=C(c1ccc(O)cc1O)[C@H]1[C@H](c2ccc(O)cc2)c2cc(O)c(O)cc2[C@H](O)[C@]1(O)C(=O)c1ccc(O)cc1 CHEMBL4438688 IC50 420.0 nM
CCCC[C@H](NC(=O)O[C@H](Cn1cc(-c2ccc(C(F)(F)F)cc2)cn1)C(C)(C)C)C(=O)C(=O)Nc1ccn[nH]1 CHEMBL190053 IC50 430.0 nM
COc1c(O)c(CC=C(C)C)c(O)c2c(=O)c3c(CC=C(C)C)ccc(O)c3n(C)c12 CHEMBL1668597 Ki 500.0 nM
Cc1cc(C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NCC#N)c(C)s1 CHEMBL561586 pIC50 501.19 nM
CCc1cc(C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NCC#N)n(C)n1 CHEMBL563886 pIC50 501.19 nM
CC(C)c1cc(C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NCC#N)n(C)n1 CHEMBL562462 pIC50 501.19 nM
O=C(N[C@H](C(=O)N1C[C@H](F)[C@H]2OCC(=O)[C@H]21)C1CCCCC1)c1ccccc1 CHEMBL3648397 Ki 700.0 nM
O=C1c2ccc(O)cc2OC2c3cc(O)c(O)cc3[C@@H](c3ccc(O)cc3)[C@@H](C(=O)c3ccc(O)cc3O)C12 CHEMBL4462944 IC50 700.0 nM
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 CHEMBL481611 IC50 762.0 nM
N#CCNC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)c1ccccc1 CHEMBL550246 pIC50 794.33 nM
Cc1cccc(C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NCC#N)c1 CHEMBL561927 pIC50 794.33 nM
CCCCc1ccc(-c2cc(=O)c3ccccc3[nH]2)cc1 CHEMBL2042446 Ki 800.0 nM
O=C(O)c1cc2ccccc2cc1Nc1ccc(OCc2ccccc2)c([N+](=O)[O-])c1 CHEMBL2042454 Ki 800.0 nM
N#Cc1nc(Nc2cccc(Cl)c2)nc(NC2CCCC2)n1 CHEMBL567785 pIC50 831.76 nM
CC(C)CO[C@H]1CCN2C[C@H]1OC2=O CHEMBL230478 IC50 894.0 nM
Cc1ccc(C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NCC#N)cc1 CHEMBL560785 pIC50 1000.0 nM
Cc1cc(C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NCC#N)c2cc(C)ccc2c1 CHEMBL549365 pIC50 1000.0 nM
COc1cc(O)c2c(=O)c3cccc(O)c3n(C)c2c1OC CHEMBL451705 Ki 1000.0 nM