Cc1cccc(SCc2cncc(-c3ccc4c(c3)CCC(=O)N4C)c2)n1 CHEMBL3916961 EC50 0.1 nM
N#Cc1ccc([C@H]2CCCCc3cncn32)c(-c2ccc(F)cc2)c1 CHEMBL3099704 IC50 0.3 nM
CCOC(=O)c1cncn1[C@H](C)c1ccccc1 CHEMBL681 IC50 0.5 nM
O=c1c2ccccc2oc2c(Cl)ccc(Cn3ccnc3)c12 CHEMBL2333326 IC50 0.5 nM
CCOC(=O)c1cncn1C(C)c1ccccc1 CHEMBL23731 IC50 0.5 nM
CS(=O)(=O)N1CCC(C(O)c2cncnc2Sc2ccc(F)cc2)CC1 CHEMBL4088766 IC50 0.6 nM
CN1C(=O)CCc2cc(-c3cncc(COc4cnc(Cl)nc4)c3)ccc21 CHEMBL3930515 EC50 0.8 nM
COc1cncc(Cc2ccc(-c3ccccc3F)nc2)c1 CHEMBL4281975 IC50 0.8 nM
CN1C(=O)CCc2cc(-c3cncc(CSc4nc5ccccc5o4)c3)ccc21 CHEMBL3982418 EC50 0.9 nM
CN1C(=O)CCc2cc(-c3cncc(COc4cc(C#N)ccn4)c3)ccc21 CHEMBL3890700 EC50 0.9 nM
Cc1cncc(Cc2cc(-c3ccccc3)ns2)c1 CHEMBL4093884 IC50 1.0 nM
Cc1cncc(Cc2cc(-c3ccccc3)nn2C)c1 CHEMBL4068439 IC50 1.0 nM
CS(=O)(=O)N1CCC(C(O)(c2cncnc2Nc2ccc(F)cc2)C(F)(F)F)CC1 CHEMBL4082403 IC50 1.1 nM
CC(C)(O)c1cncc(-n2ncc3c(Cl)ccc(F)c32)c1 CHEMBL4096914 IC50 1.1 nM
c1ccc(-c2cncc(Cc3ccc(-c4ccccc4)nc3)c2)cc1 CHEMBL2417616 IC50 1.3 nM
CC(C)C(c1cc2c3c(c1)CCN3C(=O)CC2)n1ccnc1 CHEMBL2163638 IC50 1.4 nM
CC(=O)N1CCN(c2ccc(CCc3cc(F)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4279912 IC50 1.4 nM
O=C1CCc2cc(C(C3CC3)n3ccnc3)cc3c2N1CC3 CHEMBL2163639 IC50 1.5 nM
Cc1cc(C#N)ccc1[C@H]1CCc2cncn21 CHEMBL3099696 IC50 1.5 nM
CN1C(=O)CCc2cc(-c3cncc(COc4ccc(Cl)cn4)c3)c(F)cc21 CHEMBL3959070 EC50 1.6 nM
Cc1ccnc(OCc2cncc(-c3ccc4c(c3)CCC(=O)N4C)c2)c1 CHEMBL3911527 EC50 1.7 nM
CC(C)(O)c1cncc(-n2ncc3c(F)ccc(F)c32)c1 CHEMBL4069720 IC50 1.8 nM
CN1C(=O)CCc2cc(-c3cncc(COc4ccc(Cl)cn4)c3)ccc21 CHEMBL3969143 EC50 1.9 nM
N#Cc1ccc(C2C(=O)N(Cc3ccccc3)Cc3cncn32)cc1 CHEMBL1209775 IC50 2.0 nM
Cc1cncc(Cc2ccc(-c3ccccc3)nc2)c1 CHEMBL2417553 IC50 2.0 nM
O=[N+]([O-])c1ccc(-c2ccncc2)c(OCCc2ccccc2)c1 CHEMBL3421769 IC50 2.0 nM
Cc1cncc(Cc2ccc(-c3cccc(NS(C)(=O)=O)c3)nc2)c1 CHEMBL4096366 IC50 2.0 nM
Cc1cncc(Cc2ccc(S(=O)(=O)c3ccccc3F)nc2)c1 CHEMBL4079408 IC50 2.0 nM
COc1cncc(Cc2cc(-c3ccccc3)no2)c1 CHEMBL4097298 IC50 2.0 nM
N#Cc1ccc(-c2cncc(C3=NO[C@]4(C(=O)Nc5ccc6[nH]ncc6c5)[C@H]5CC[C@H](C5)[C@H]34)c2)cc1 CHEMBL5198576 IC50 2.0 nM
CC1(COC2CCc3c(-c4ccc(C(F)(F)F)cc4)cncc32)COC1 CHEMBL3981240 EC50 2.3 nM
N#Cc1ccc([C@H]2CCc3cncn32)c(F)c1 CHEMBL3099695 IC50 2.5 nM
c1ccc(C(c2ccccc2)(c2ccccc2)n2ccnc2)cc1 CHEMBL1651507 IC50 3.0 nM
Cc1cncc(Cc2ccc(-c3ccccc3F)nc2)c1 CHEMBL4067404 IC50 3.0 nM
Cc1cncc(Cc2ccc(Sc3ccccc3F)nc2)c1 CHEMBL4103666 IC50 3.0 nM
C(=C1/CCCc2ccccc21)\c1c[nH]cn1 CHEMBL367719 IC50 3.3 nM
O=C1CCc2cc(C(C3CCC3)n3ccnc3)cc3c2N1CC3 CHEMBL2163640 IC50 3.4 nM
Cc1cc(OCc2cncc(-c3ccc4c(c3)CCC(=O)N4C)c2)nc(C(F)(F)F)c1 CHEMBL3896815 EC50 3.6 nM
CC1(c2cncc(-c3ccc(C#N)c(F)c3)c2)OCCO1 CHEMBL5406728 IC50 3.8 nM
c1ccc(C(Cn2ccnc2)(c2ccccc2)c2ccccc2)cc1 CHEMBL1651508 IC50 4.0 nM
CC(c1cccnc1)c1cc2c3c(c1)CCN3C(=O)CC2 CHEMBL2312967 IC50 4.0 nM
Cc1cncc(Cc2ccc(-c3ccoc3)nc2)c1 CHEMBL4078318 IC50 4.0 nM
Cc1cncc(Cc2ccc(NC3CC3)nc2)c1 CHEMBL4059931 IC50 4.0 nM
O=S(=O)(c1cccc(OC(F)(F)F)c1)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4288256 IC50 4.0 nM
N#Cc1cccc(S(=O)(=O)N2CCN(c3ccc(/C=C/c4cc(Cl)cc(Cn5ccnc5)c4)cc3)CC2)c1 CHEMBL4292267 IC50 4.0 nM
O=[N+]([O-])c1cccc(S(=O)(=O)N2CCN(c3ccc(/C=C/c4cc(Cl)cc(Cn5ccnc5)c4)cc3)CC2)c1 CHEMBL4287787 IC50 4.0 nM
O=C(c1cccc([N+](=O)[O-])c1)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4293550 IC50 4.0 nM
N#Cc1cccc(C(=O)N2CCN(c3ccc(/C=C/c4cc(Cl)cc(Cn5ccnc5)c4)cc3)CC2)c1 CHEMBL4283190 IC50 4.0 nM
O=S(=O)(c1cccnc1)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4128621 IC50 4.0 nM
Cc1ccnc(OCc2cncc(-c3cc4c(cc3F)N(C)C(=O)CC4)c2)c1 CHEMBL3986059 EC50 4.1 nM
CC(C)Oc1ccc2c(=O)c3ccc(Cn4ccnc4)cc3oc2c1 CHEMBL4207323 IC50 4.1 nM
Cc1nccc(OCc2cncc(-c3ccc4c(c3)CCC(=O)N4C)c2)n1 CHEMBL3939497 EC50 4.2 nM
O=C1NCc2cc(-c3cncc4ccccc34)ccc2N1 CHEMBL3397607 IC50 4.5 nM
O=c1c2ccc(Cn3ccnc3)cc2oc2cc(OCC3CC3)ccc12 CHEMBL4203608 IC50 4.7 nM
c1ccc(Cn2cncc2-c2ccccc2)cc1 CHEMBL463582 pIC50 4.786 nM
Cc1cccc(OCc2cncc(-c3ccc4c(c3)CCC(=O)N4C)c2)n1 CHEMBL3923975 EC50 4.8 nM
O=C(c1cccnc1)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4294598 IC50 4.9 nM
Cc1c(C)c(C)c(Cn2ccnc2)c(C)c1C CHEMBL1651495 IC50 5.0 nM
c1cn(CC23CC4CC(CC(C4)C2)C3)cn1 CHEMBL1651505 IC50 5.0 nM
COc1cncc(Cc2ccc(-c3ccccc3)nc2)c1 CHEMBL2417614 IC50 5.0 nM
O=c1cc(Cn2ccnc2)c2ccc(OCc3cccc(OC(F)(F)F)c3)cc2o1 CHEMBL1688894 IC50 5.0 nM
COc1cccc(S(=O)(=O)N2CCCc3cc(Cc4cccnc4)ccc32)c1 CHEMBL3337695 IC50 5.0 nM
CC1(O)CCc2c(-c3ccc(C(F)(F)F)cc3)cncc21 CHEMBL3956360 EC50 5.0 nM
Cc1cncc(Cc2ccc(Sc3ccccc3)nc2)c1 CHEMBL4095910 IC50 5.0 nM
Cc1cncc(Cc2cc(-c3ccccc3)no2)c1 CHEMBL4079276 IC50 5.0 nM
CC(C)S(=O)(=O)N1CCN(c2ccc(/C=C/c3cc(F)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4127378 IC50 5.0 nM
O=c1c2ccccc2oc2c(OCC3CC3)ccc(Cn3ccnc3)c12 CHEMBL2333334 IC50 5.5 nM
Cc1ccccc1-c1cncn1Cc1ccc(C#N)cc1 CHEMBL610513 IC50 5.7 nM
O=c1c2ccc(Cn3ccnc3)cc2oc2cc(OC3CCCC3)ccc12 CHEMBL4216471 IC50 5.8 nM
c1ccc(-c2ccc(Cc3cncc4ccccc34)cn2)cc1 CHEMBL2417635 IC50 6.0 nM
COc1cccc(S(=O)(=O)N2CCCc3cc(Cc4ccncc4)ccc32)c1 CHEMBL3337694 IC50 6.0 nM
O=[N+]([O-])c1ccc(-c2cccnc2)c(OCCCc2ccccc2)c1 CHEMBL3421767 IC50 6.0 nM
O=[N+]([O-])c1ccc(Cc2ccncc2)c(OCCc2ccccc2)c1 CHEMBL3421786 IC50 6.0 nM
CC(O)(c1cncnc1Nc1ccc(F)cc1)C1CCN(S(C)(=O)=O)CC1 CHEMBL4070323 IC50 6.0 nM
O=S(=O)(C1CC1)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)OC3)cc2)CC1 CHEMBL4283588 IC50 6.0 nM
O=C(Nc1ccc2[nH]ncc2c1)[C@]12ON=C(c3cncc(-c4ccc(F)cc4)c3)[C@H]1[C@@H]1CC[C@H]2C1 CHEMBL5177141 IC50 6.0 nM
C(=C1/CCc2ccccc21)\c1c[nH]cn1 CHEMBL178036 IC50 6.1 nM
Cc1cccc(-c2cncn2Cc2ccc(C#N)cc2)c1 CHEMBL607862 pIC50 6.166 nM
N#Cc1ccc(C2CCCc3cncn32)cc1 CHEMBL9298 IC50 6.3 nM
CN1C(=O)CCc2cc(-c3cncc(COc4ccc(F)cn4)c3)ccc21 CHEMBL3948274 EC50 6.3 nM
CCC(c1cc2c3c(c1)CCN3C(=O)CC2)n1ccnc1 CHEMBL2163637 IC50 6.5 nM
O=c1c2ccc(Cn3ccnc3)cc2oc2cc(Oc3ccccc3)ccc12 CHEMBL4206710 IC50 6.5 nM
O=c1c2ccc(Cl)cc2oc2cc(Cn3ccnc3)ccc12 CHEMBL4209612 IC50 6.6 nM
O=c1c2ccccc2oc2c(Br)ccc(Cn3ccnc3)c12 CHEMBL78322 IC50 6.7 nM
N#Cc1ccc2c(c1)CCC/C2=C/c1c[nH]cn1 CHEMBL367483 IC50 6.9 nM
CN1C(=O)CCc2cc(-c3cncc4ccccc34)ccc21 CHEMBL451505 IC50 6.9 nM
COc1ccc(-c2oc3ccccc3c(=O)c2Cn2ccnc2)cc1 CHEMBL212473 IC50 7.0 nM
Brc1ccc(Cn2cncc2-c2ccccc2)cc1 CHEMBL597173 IC50 7.0 nM
O=S(=O)(c1c[nH]cn1)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4127240 IC50 7.0 nM
N#Cc1cccc(CN2CCN(c3ccc(/C=C/c4cc(Cl)cc(Cn5ccnc5)c4)cc3)CC2)c1 CHEMBL4279727 IC50 7.0 nM
N#Cc1ccc([C@H]2CCCCc3cncn32)c(F)c1 CHEMBL3099683 IC50 7.2 nM
CN1C(=O)CCc2cc(-c3cncc(COc4cccc(F)n4)c3)ccc21 CHEMBL3950364 EC50 7.5 nM
Cc1ccncc1Cc1ccc(-c2ccccc2)nc1 CHEMBL2417637 IC50 8.0 nM
O=[N+]([O-])c1ccc(-c2ccncc2)c(OCCCc2ccccc2)c1 CHEMBL3421770 IC50 8.0 nM
COC1CCCc2c(-c3ccc(C#N)cc3)cncc21 CHEMBL3906279 EC50 8.0 nM
O=C(Nc1ccc2[nH]ncc2c1)[C@]12ON=C(c3cncc(-c4cccc(F)c4)c3)[C@H]1[C@@H]1CC[C@H]2C1 CHEMBL5175710 IC50 8.0 nM
CN1C(=O)CCc2cc(-c3cncc(COc4ccccn4)c3)ccc21 CHEMBL3936019 EC50 8.7 nM
Cc1cncc(Cc2cnc(-c3ccccc3)s2)c1 CHEMBL4070031 IC50 9.0 nM
O=C(Nc1ccc2[nH]ncc2c1)[C@]12ON=C(c3cccnc3)[C@H]1[C@@H]1CC[C@H]2C1 CHEMBL5184829 IC50 9.0 nM
CN1C(=O)CCc2cc(-c3cncc(COc4cccc(Cl)n4)c3)ccc21 CHEMBL3897028 EC50 9.1 nM
N#Cc1ccc([C@H]2CCCc3cncn32)cc1 CHEMBL287677 IC50 9.5 nM
O=c1c(Cc2c[nH]cn2)coc2cc(F)ccc12 CHEMBL3793576 IC50 9.7 nM
COc1ccc2cc(-c3cncc(C(C)OC)c3)ccc2c1 CHEMBL500392 IC50 10.0 nM
CS(=O)(=O)N1CCC(C(O)c2cncnc2Nc2ccc(F)cc2)CC1 CHEMBL4099824 IC50 10.0 nM
CC(C)(O)c1cncc(-n2ncc3cccc(F)c32)c1 CHEMBL4075377 IC50 10.74 nM
COc1ccc(Cn2cncc2-c2ccccc2)cc1 CHEMBL591697 pIC50 10.96 nM
c1cn(C(c2ccc(-c3ccsc3)nc2)C2CC2)cn1 CHEMBL2417626 IC50 11.0 nM
CS(=O)(=O)N1CCC(C(O)c2cncnc2Nc2ccc(C#N)cc2)CC1 CHEMBL4070230 IC50 11.0 nM
Clc1cc(/C=C/c2ccc(N3CCN(CC4CC4)CC3)cc2)cc(Cn2ccnc2)c1 CHEMBL4279416 IC50 11.0 nM
Fc1ccc2c(c1)CC/C2=C/c1c[nH]cn1 CHEMBL179247 IC50 11.17 nM
O=c1c2ccc(Br)cc2oc2cc(Cn3ccnc3)ccc12 CHEMBL4214521 IC50 11.4 nM
O=c1c(Cn2ccnc2)c(-c2ccccc2)oc2ccccc12 CHEMBL213587 IC50 12.0 nM
COc1ccc(Cn2cncc2CCCO)cc1 CHEMBL597577 IC50 12.0 nM
CC(C)C(c1ccc(-c2ccccc2)nc1)n1ccnc1 CHEMBL2417622 IC50 12.0 nM
N#Cc1ccc(-c2ccncc2)c(OCCc2ccccc2)c1 CHEMBL3421780 IC50 12.0 nM
N#Cc1ccc(-c2cncc3c2CCC3O)cc1 CHEMBL3975309 EC50 12.0 nM
CC(=O)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)OC3)cc2)CC1 CHEMBL4289930 IC50 12.0 nM
CC(=O)N1CCN(c2ccc(CO[C@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)OC3)cc2)CC1 CHEMBL4288652 IC50 12.0 nM
O=S(=O)(c1cccnc1)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)OC3)cc2)CC1 CHEMBL4283318 IC50 12.0 nM
N#Cc1cccc(-c2cncc(C3=NO[C@]4(C(=O)Nc5ccc6[nH]ncc6c5)[C@H]5CC[C@H](C5)[C@H]34)c2)c1 CHEMBL5209512 IC50 12.0 nM
N#Cc1ccc2c(c1)CC/C2=C/c1ncc[nH]1 CHEMBL175091 IC50 12.3 nM
CN1C(=O)CCc2cc(-c3cncc(COc4ccnc(C(F)(F)F)n4)c3)ccc21 CHEMBL3902519 EC50 12.3 nM
O=c1c2ccc(F)cc2oc2cc(Cn3ccnc3)ccc12 CHEMBL4218934 IC50 12.3 nM
O=C1CCc2cc(-c3cncc4ccccc34)cc3c2N1CC3 CHEMBL1765214 IC50 13.0 nM
O=C1CCc2cc(C(c3cccs3)n3ccnc3)cc3c2N1CC3 CHEMBL2163651 IC50 13.0 nM
O=[N+]([O-])c1ccc(-c2cccnc2)c(OCCc2ccccc2)c1 CHEMBL3421766 IC50 13.0 nM
CS(=O)(=O)N1CCC(C(O)c2cncnc2Nc2cccc(F)c2)CC1 CHEMBL4072943 IC50 13.0 nM
CC(C)C(O)(c1cncnc1Nc1ccc(F)cc1)C1CCN(S(C)(=O)=O)CC1 CHEMBL4093575 IC50 13.0 nM
O=S(=O)(CCCCl)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4286077 IC50 13.0 nM
O=S(=O)(c1cccc(OC(F)(F)F)c1)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)OC3)cc2)CC1 CHEMBL4284316 IC50 13.0 nM
CCC(C)Oc1ccc(Cn2ccnc2)c2c(=O)c3ccccc3oc12 CHEMBL2333333 IC50 13.1 nM
N#Cc1ccc(Cn2ccnc2)c2c(=O)c3ccccc3oc12 CHEMBL442373 IC50 13.4 nM
COC(C)c1cncc(-c2ccc(C#N)c(F)c2)c1 CHEMBL5394924 IC50 13.8 nM
c1ccc(-c2cc(Cn3ccnc3)sn2)cc1 CHEMBL4072324 IC50 14.0 nM
Cc1cncc(Cc2cnc(-c3ccccc3)o2)c1 CHEMBL4097224 IC50 14.0 nM
O=S(=O)(c1c[nH]cn1)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)OC3)cc2)CC1 CHEMBL4288383 IC50 14.0 nM
CN1C(=O)CCc2cc(-c3cncc(CSc4ncccc4C(F)(F)F)c3)ccc21 CHEMBL3944873 EC50 14.3 nM
Cc1cccc(NC(=O)Cc2cncc(-c3ccc4c(c3)CCC(=O)N4C)c2)n1 CHEMBL3960269 EC50 14.5 nM
CC(C)(C(=O)c1cccnc1)c1cccnc1 CHEMBL934 IC50 14.6 nM
Nc1ccc(SC[C@H]2CO[C@@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1 CHEMBL305220 Ki 15.0 nM
N#Cc1ccc2c(c1)CC/C2=C\c1c[nH]cn1 CHEMBL177921 IC50 15.0 nM
COC(=O)c1cncc(-c2ccc3cc(OC)ccc3c2)c1 CHEMBL500146 IC50 15.0 nM
c1ccc(-c2ccccc2Cn2ccnc2)cc1 CHEMBL1651496 IC50 15.0 nM
O=C(Cn1ccnc1)c1ccc(OCc2cccc(OC(F)(F)F)c2)cc1 CHEMBL3359961 IC50 15.0 nM
O=C1Nc2ccc(-c3cncc4ccccc34)cc2CO1 CHEMBL3397605 IC50 15.0 nM
COc1cccc(-c2cncc(C3=NO[C@]4(C(=O)Nc5ccc6[nH]ncc6c5)[C@H]5CC[C@H](C5)[C@H]34)c2)c1 CHEMBL5186306 IC50 15.0 nM
O=c1c2ccccc2oc2c(Cn3ccnc3)cccc12 CHEMBL1083971 IC50 15.1 nM
COc1ccc2c(=O)c3ccc(Cn4ccnc4)cc3oc2c1 CHEMBL4205228 IC50 15.4 nM
N#Cc1ccc(-c2cncc(C3OCCO3)c2)cc1F CHEMBL5413320 IC50 15.5 nM
Fc1ccc(Cn2cncc2-c2ccccc2)cc1 CHEMBL610501 pIC50 15.85 nM
c1csc(-c2ncccc2Cn2ccnc2)c1 CHEMBL2011431 IC50 16.0 nM
O=C1CCc2cc(Cc3cccnc3)cc3c2N1CC3 CHEMBL2312965 IC50 16.0 nM
CS(=O)(=O)N1CCC(C(O)c2cncnc2Nc2ccc(C(F)(F)F)cc2)CC1 CHEMBL4091167 IC50 16.0 nM
Cc1cncc(Cc2ccc(-c3ccnn3C)nc2)c1 CHEMBL4086201 IC50 16.0 nM
CN1C(=O)CCc2cc(-c3cncc(COc4cccc(Cl)n4)c3)c(F)cc21 CHEMBL3928063 EC50 16.3 nM
Oc1ccc(-c2ccc(Cn3ccnc3)cn2)cc1F CHEMBL2011246 IC50 17.0 nM
CC(c1cc2c3c(c1)CCN3C(=O)CC2)n1ccnc1 CHEMBL2163636 IC50 17.0 nM
Cn1ccnc1S(=O)(=O)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3891718 IC50 17.0 nM
Cn1nc(-c2ccccc2)cc1Cc1cncc(O)c1 CHEMBL4282375 IC50 17.0 nM
Fc1cc(/C=C/c2ccc(N3CCN(C4=NCCCO4)CC3)cc2)cc(Cn2ccnc2)c1 CHEMBL4127969 IC50 17.0 nM
O=C(Nc1cnc2[nH]ccc2c1)[C@]12ON=C(c3cccnc3)[C@H]1[C@@H]1CC[C@H]2C1 CHEMBL5174912 IC50 17.0 nM
O=C(Nc1ccc2[nH]ncc2c1)[C@]12ON=C(c3cncc(-c4cccc(C(F)(F)F)c4)c3)[C@H]1[C@@H]1CC[C@H]2C1 CHEMBL5201480 IC50 17.0 nM
Cc1cncc(-c2nc3cc(F)c(F)cc3n2C2CC2)c1C CHEMBL3582482 IC50 17.7 nM
OCCCc1cncn1Cc1ccc(Br)cc1 CHEMBL598810 IC50 18.0 nM
CCN(CC)c1cncc(-c2ccc(C#N)c(F)c2)n1 CHEMBL5439285 IC50 18.6 nM
Clc1ccc2c(c1)/C(=C/c1c[nH]cn1)CCC2 CHEMBL175144 IC50 18.7 nM
c1ccc(-c2csc(Cn3ccnc3)c2)cc1 CHEMBL403598 IC50 19.0 nM
C=C(c1cc2c3c(c1)CCN3C(=O)CC2)n1ccnc1 CHEMBL2163641 IC50 19.0 nM
Cc1ccc(Nc2ncncc2C(O)C2CCN(S(C)(=O)=O)CC2)cc1 CHEMBL4092081 IC50 19.0 nM
O=C(C1CC1)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4280777 IC50 19.0 nM
O=c1c2ccccc2oc2c(I)ccc(Cn3ccnc3)c12 CHEMBL2333327 IC50 19.2 nM
O=c1c2ccc(Cn3ccnc3)cc2oc2cc([N+](=O)[O-])ccc12 CHEMBL4214016 IC50 19.2 nM
Clc1ccc2c(c1)CC/C2=C/c1c[nH]cn1 CHEMBL175688 IC50 19.5 nM
N#Cc1ccc(Cn2cncc2-c2ccccc2F)cc1 CHEMBL599603 pIC50 19.95 nM
O=C1CCc2cc(C(c3ccco3)n3ccnc3)cc3c2N1CC3 CHEMBL2163650 IC50 20.0 nM
O=c1cc(Cn2ccnc2)c2ccc(OCc3cccc(C(F)(F)F)c3)cc2o1 CHEMBL1688892 IC50 20.0 nM
O=c1cc(Cn2ccnc2)c2ccc(OCc3cccc([N+](=O)[O-])c3)cc2o1 CHEMBL1688895 IC50 20.0 nM
Cc1cncc(Cc2ccc(S(=O)(=O)c3ccccc3)nc2)c1 CHEMBL4068593 IC50 20.0 nM
Fc1ccc2c(c1)CC/C2=C\c1c[nH]cn1 CHEMBL359817 IC50 20.6 nM
COC(C)(C)CC1n2cncc2CN([C@@H](C)c2ccc(Cl)cc2)S1(=O)=O CHEMBL1209693 IC50 20.6 nM
Cc1c(COc2cccc(F)n2)cncc1-c1cc2c(cc1F)N(C)C(=O)CC2 CHEMBL3984990 EC50 20.8 nM
CSc1cncc(-c2ccc(C#N)c(F)c2)c1 CHEMBL5408597 IC50 20.8 nM
COc1ccc(-c2cncc(-c3cc4c5c(c3)CCN5C(=O)CC4)c2)cc1 CHEMBL1765228 IC50 21.0 nM
CC(c1ccc(-c2ccsc2)nc1)n1ccnc1 CHEMBL2417625 IC50 21.0 nM
c1ccc(-c2ccc(C(C3CC3)n3ccnc3)cn2)cc1 CHEMBL2417621 IC50 21.0 nM
Cc1ccc(C2(O)CCCc3c(-c4ccc(C#N)cc4)cncc32)cc1C CHEMBL3927826 EC50 21.0 nM
O=c1c2ccccc2[nH]c2c(Cn3ccnc3)cccc12 CHEMBL3219070 IC50 21.2 nM
Cc1cncc(Cc2ccc(N3CCOCC3)nc2)c1 CHEMBL4088179 IC50 22.0 nM
Cc1nn(-c2cncc(C(C)(C)O)c2)c2cccc(F)c12 CHEMBL4080420 IC50 22.0 nM
O=S(=O)(C1CC1)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4127385 IC50 22.0 nM
O=C(Nc1ccc2[nH]ccc2c1)[C@]12ON=C(c3cccnc3)[C@H]1[C@@H]1CC[C@H]2C1 CHEMBL5204043 IC50 22.0 nM
O=c1c2ccccc2oc2c([N+](=O)[O-])ccc(Cn3ccnc3)c12 CHEMBL307160 IC50 22.3 nM
N#Cc1ccc(-c2cncc(OCCCF)c2)cc1Cl CHEMBL5415822 IC50 22.4 nM
O=[N+]([O-])c1ccc(-c2cccnc2)c(OCc2ccccc2)c1 CHEMBL3421765 IC50 23.0 nM
CCS(=O)(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4128449 IC50 23.0 nM
Clc1ccc([C@]2(Cn3ccnc3)OC[C@@H](OCc3ccc(-c4ccncc4)cc3)CO2)c(Cl)c1 CHEMBL4290805 IC50 23.0 nM
Brc1ccc2c(c1)CC/C2=C/c1c[nH]cn1 CHEMBL174579 IC50 23.5 nM
N#Cc1ccc(-c2cncc(-c3ccc(F)cc3)c2)cc1F CHEMBL5402622 IC50 23.7 nM
N#Cc1ccc(-c2cncc(-c3ccccc3F)c2)cc1F CHEMBL5415328 IC50 23.9 nM
Cc1cc(C)c(Cn2ccnc2)c(C)c1 CHEMBL1649605 IC50 24.0 nM
O=C(Cn1ccnc1)c1ccc(OCc2cccc([N+](=O)[O-])c2)cc1 CHEMBL3359962 IC50 24.0 nM
CS(=O)(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4126412 IC50 24.0 nM
CCOc1cncc(-c2ccc(C#N)c(F)c2)c1 CHEMBL5409957 IC50 24.3 nM
CC(C)CCOc1ccc(Cn2ccnc2)c2c(=O)c3ccccc3oc12 CHEMBL2333332 IC50 24.4 nM
Clc1ccc(Cn2cncc2-c2ccccc2)cc1 CHEMBL597101 IC50 25.0 nM
O=c1cc(Cn2ccnc2)c2ccc(OCc3ccc(OC(F)(F)F)cc3)cc2o1 CHEMBL1688899 IC50 25.0 nM
CC(C)S(=O)(=O)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)OC3)cc2)CC1 CHEMBL4287608 IC50 25.0 nM
O=C(Nc1ccc2cc[nH]c2c1)[C@]12ON=C(c3cccnc3)[C@H]1[C@@H]1CC[C@H]2C1 CHEMBL5203687 IC50 25.0 nM
CCOc1ccc(Cn2ccnc2)c2c(=O)c3ccccc3oc12 CHEMBL2333330 IC50 25.4 nM
C(=C1\CCc2ccccc21)\c1c[nH]cn1 CHEMBL177468 IC50 25.9 nM
Fc1ccc2c(c1)CC/C2=C/c1cccc2cnccc12 CHEMBL363849 IC50 26.0 nM
Cc1cccc(S(=O)(=O)N2CCCc3cc(-c4cccnc4)ccc32)c1 CHEMBL3337679 IC50 26.0 nM
FC(F)(F)c1ccc(-c2ccncc2)c(OCCc2ccccc2)c1 CHEMBL3421778 IC50 26.0 nM
CC(C)CC1n2cncc2CN(Cc2ccc(F)cc2)S1(=O)=O CHEMBL1209476 IC50 26.1 nM
Brc1ccc2c(c1)CC/C2=C\c1c[nH]cn1 CHEMBL177293 IC50 26.2 nM
N#Cc1ccc(Cn2cncc2-c2ccc(F)cc2)cc1 CHEMBL598790 pIC50 26.92 nM
Fc1ccc2c(c1)CC/C2=C\c1cncnc1 CHEMBL195248 IC50 27.0 nM
O=c1c(Cn2ccnc2)c(-c2ccc(Br)cc2)oc2ccccc12 CHEMBL377766 IC50 27.0 nM
O=C1CCc2cc(C(c3ccc(F)cc3)n3ccnc3)cc3c2N1CC3 CHEMBL2163644 IC50 27.0 nM
CCOC(=O)CNC(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4291002 IC50 27.0 nM
O=S(=O)(CCCCl)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)OC3)cc2)CC1 CHEMBL4284620 IC50 27.0 nM
N#Cc1ccc(Cn2cncc2-c2ccccc2)cc1 CHEMBL597578 IC50 28.0 nM
CCC(c1ccc(-c2ccccc2)nc1)n1ccnc1 CHEMBL2417620 IC50 28.0 nM
COc1cccc(S(=O)(=O)N2CCCc3cc(-c4cccnc4)ccc32)c1 CHEMBL3337676 IC50 28.0 nM
O=C1COc2cc(-c3cncc4ccccc34)ccc2N1 CHEMBL3397600 IC50 28.0 nM
CC1(C)Cc2c(-c3ccc(C#N)cc3)cncc2C1O CHEMBL3951086 EC50 28.0 nM
Clc1ccc2c(c1)CC/C2=C\c1c[nH]cn1 CHEMBL177692 IC50 28.7 nM
c1coc(-c2cc(Cn3ccnc3)cnc2-c2ccco2)c1 CHEMBL2011437 IC50 29.0 nM
O=C1CCc2cc(C(c3cccc(F)c3)n3ccnc3)cc3c2N1CC3 CHEMBL2163643 IC50 29.0 nM
O=S(=O)(C(F)F)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3968178 IC50 29.0 nM
Oc1cncc(Cc2ccc(-c3ccccc3F)nc2)c1 CHEMBL4290660 IC50 29.0 nM
O=c1c(Cc2c[nH]cn2)coc2ccccc12 CHEMBL3792819 IC50 29.5 nM
N#Cc1cccc(COc2ccc(C(=O)Cn3ccnc3)cc2)c1 CHEMBL3359963 IC50 30.0 nM
CCNC(=O)OC1CCCc2c(-c3ccc(C#N)cc3)cncc21 CHEMBL3976971 EC50 30.0 nM
COC(=O)CCc1cncn1Cc1ccc(C#N)cc1 CHEMBL591229 pIC50 30.9 nM
COCc1cncc(-c2ccc3cc(OC)ccc3c2)c1 CHEMBL500421 IC50 31.0 nM
O=c1cc(Cn2ccnc2)c2ccc(OCc3cccc(Cl)c3)cc2o1 CHEMBL1688890 IC50 31.0 nM
N#Cc1ccc(-c2cncc3c2CCCC3O)cc1 CHEMBL3915255 EC50 31.0 nM
O=C(Nc1ccc2[nH]ncc2c1)[C@]12ON=C(c3cncc(Br)c3)[C@H]1[C@@H]1CC[C@H]2C1 CHEMBL5171157 IC50 31.0 nM
C(=C1\CCCc2ccccc21)\c1c[nH]cn1 CHEMBL362187 IC50 31.4 nM
N#Cc1ccc(Cn2cncc2-c2cccc(F)c2)cc1 CHEMBL598789 IC50 32.0 nM
Cc1cc(C)cc(Cn2ccnc2)c1 CHEMBL1651494 IC50 32.0 nM
c1ccc(-c2ccc(Cn3ccnc3)cc2)cc1 CHEMBL1235146 IC50 32.0 nM
c1ccc(-c2ccc(Cc3cccnc3)cn2)cc1 CHEMBL2417633 IC50 32.0 nM
O=S(=O)(N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1)C(F)(F)F CHEMBL3938615 IC50 32.0 nM
COc1cccc(NC(=O)[C@]23ON=C(c4cccnc4)[C@H]2[C@@H]2CC[C@H]3C2)c1 CHEMBL5204850 IC50 32.0 nM
O=C1CCc2cc(-c3cncc4ccccc34)ccc2N1 CHEMBL456390 IC50 33.0 nM
CC(c1ccc(-c2ccccc2)nc1)n1ccnc1 CHEMBL2417619 IC50 33.0 nM
CC(C)(O)c1cncc(-c2nc3ccc(F)cn3c2Cl)c1 CHEMBL3976931 IC50 33.0 nM
N#Cc1ccc(-c2cncc3ccccc23)cc1F CHEMBL5410752 IC50 33.7 nM
Fc1ccc2c(c1)CC/C2=C/c1ccncc1 CHEMBL179144 IC50 34.0 nM
O=C1CCc2cc(-c3cncc4ccccc34)cc3c2N1CCC3 CHEMBL1765215 IC50 34.0 nM
CC(=O)n1ccc2cc(-c3cncc4ccccc34)ccc21 CHEMBL3287192 IC50 34.0 nM
Nc1ccc(SC[C@@H]2CO[C@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1 CHEMBL70611 Ki 35.0 nM
N#Cc1cccc(NC(=O)[C@]23ON=C(c4cccnc4)[C@H]2[C@@H]2CC[C@H]3C2)c1 CHEMBL5175708 IC50 35.0 nM
O=C1CCc2cc(C(c3cccnc3)c3cccc(Cl)c3)cc3c2N1CC3 CHEMBL2312971 IC50 36.0 nM
Cc1c(-c2cncc(C(C)(C)O)c2)nc2ccc(F)cn12 CHEMBL3968397 IC50 37.0 nM
N#Cc1cccc(S(=O)(=O)N2CCN(c3ccc(CO[C@H]4CO[C@](Cn5ccnc5)(c5ccc(Cl)cc5Cl)OC4)cc3)CC2)c1 CHEMBL4279441 IC50 37.0 nM
O=C(Nc1ccc2[nH]ncc2c1)[C@]12ON=C(c3cncc(-c4ccsc4)c3)[C@H]1[C@@H]1CC[C@H]2C1 CHEMBL5195761 IC50 37.0 nM
FC(F)(F)c1cncc(Cc2ccc(-c3ccccc3)nc2)c1 CHEMBL2417613 IC50 38.0 nM
N#Cc1ccc(-c2cccnc2)c(OCCc2ccccc2)c1 CHEMBL3421779 IC50 38.0 nM
N#Cc1ccc(-c2cncc(F)c2)cc1F CHEMBL5423538 IC50 38.6 nM
N#Cc1ccc([C@@H]2CCCc3cncn32)cc1 CHEMBL31215 IC50 40.0 nM
O=C1CCc2cc(-c3cncc(-c4ccc(F)cc4)c3)cc3c2N1CC3 CHEMBL1765222 IC50 40.0 nM
c1ccc2c(-c3ccc(Cn4ccnc4)cn3)csc2c1 CHEMBL2011433 IC50 40.0 nM
COc1ccc(C(c2cc3c4c(c2)CCN4C(=O)CC3)n2ccnc2)cc1 CHEMBL2163646 IC50 40.0 nM
O=C1CCc2cc(C(c3ccccc3F)n3ccnc3)cc3c2N1CC3 CHEMBL2163642 IC50 40.0 nM
O=c1cc(Cn2ccnc2)c2ccc(OCc3cccc(F)c3)cc2o1 CHEMBL1688891 IC50 40.0 nM
CC(C)S(=O)(=O)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3894912 IC50 40.0 nM
CN1C(=O)CCc2cc(-c3cncc(CC(=O)Nc4cccc(Cl)n4)c3)ccc21 CHEMBL3967847 EC50 40.5 nM
NC(=O)COC1CCc2c(-c3ccc(C(F)(F)F)cc3)cncc21 CHEMBL3897910 EC50 40.77 nM
C=C(c1cccnc1)c1cc2c3c(c1)CCN3C(=O)CC2 CHEMBL2312966 IC50 41.0 nM
c1ccc2c(-c3ccc(Cn4ccnc4)cn3)cccc2c1 CHEMBL2011253 IC50 42.0 nM
CC(C)(O)c1cncc(-c2nc3cc(F)c(F)cc3n2C2CC2)c1 CHEMBL3582477 IC50 42.0 nM
CS(=O)(=O)N1CCC(C(O)c2cncnc2Nc2ccccc2)CC1 CHEMBL4079006 IC50 42.0 nM
Cc1cncc(Cc2ccc(-c3cnn(C)c3)nc2)c1 CHEMBL4104108 IC50 42.0 nM
c1ccc(-c2ccc(Cn3ccnc3)s2)cc1 CHEMBL1651514 IC50 43.0 nM
O=C1CCc2cc(-c3cncc(-c4ccccc4F)c3)cc3c2N1CC3 CHEMBL1765220 IC50 43.0 nM
OCCCc1cncn1Cc1ccc(Cl)cc1 CHEMBL598606 pIC50 43.65 nM
O=C1CCc2cc(-c3cncc(-c4cccc(O)c4)c3)cc3c2N1CC3 CHEMBL1765229 IC50 44.0 nM
O=C1CCc2cc(-c3cccnc3)c(OCc3ccccc3)cc2N1 CHEMBL2165320 IC50 44.0 nM
CC(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4129703 IC50 44.0 nM
Cc1cccc(COc2ccc3c(Cn4ccnc4)cc(=O)oc3c2)c1 CHEMBL1688893 IC50 45.0 nM
O=c1cc(Cn2ccnc2)c2ccc(OCc3cc(F)cc(F)c3)cc2o1 CHEMBL1688900 IC50 45.0 nM
CN1C(=O)CCc2cc(-c3cncc(CSc4ncccc4Cl)c3)ccc21 CHEMBL3973445 EC50 45.7 nM
CC1COC(c2cncc(-c3ccc(C#N)c(F)c3)c2)O1 CHEMBL5396904 IC50 45.9 nM
c1ccc(-c2cccc(Cn3ccnc3)c2)cc1 CHEMBL1651497 IC50 46.0 nM
c1ccc(-c2ccc(Cn3ccnc3)o2)cc1 CHEMBL1651513 IC50 46.0 nM
COc1ccc(-c2ccncc2)c(OCCc2ccccc2)c1 CHEMBL3421776 IC50 46.0 nM
N#Cc1ccc(NC(=O)[C@]23ON=C(c4cccnc4)[C@H]2[C@@H]2CC[C@H]3C2)cc1 CHEMBL5186765 IC50 46.0 nM
O=C(Nc1ccc2[nH]ncc2c1)[C@]12ON=C(c3cncc(-c4ccoc4)c3)[C@H]1[C@@H]1CC[C@H]2C1 CHEMBL5196347 IC50 46.0 nM
CC(C)Oc1cncc(-c2ccc(C#N)c(F)c2)c1 CHEMBL5424502 IC50 46.2 nM
CC(O)(c1cncc(-n2ncc3cc(F)ccc32)c1)C(F)(F)F CHEMBL4101709 IC50 47.0 nM
Cc1cncc(-c2ccc(C#N)c(F)c2)c1 CHEMBL5413659 IC50 47.8 nM
N#Cc1ccc(Cn2cncc2CCCO)cc1 CHEMBL598399 pIC50 47.86 nM
COC(=O)c1cncn1Cc1ccc(C#N)cc1 CHEMBL591698 pIC50 47.86 nM
Cc1cccc(Cn2ccnc2)c1 CHEMBL1651493 IC50 48.0 nM
COc1cccc(COc2ccc3c(Cn4ccnc4)cc(=O)oc3c2)c1 CHEMBL3359952 IC50 48.0 nM
CC(C)Oc1ccc(COc2ccc3c(Cn4ccnc4)cc(=O)oc3c2)cc1 CHEMBL3359955 IC50 48.0 nM
Cc1cncc(Cc2csnc2-c2ccccc2)c1 CHEMBL4066317 IC50 48.0 nM
O=S(=O)(c1ccc(F)cc1)N1CCCc2cc(-c3cccnc3)ccc21 CHEMBL3337684 IC50 49.0 nM
CS(=O)(=O)N1CCN(c2ccc(/C=C/c3cc(F)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4125996 IC50 49.0 nM
O=C(Nc1cccc(F)c1)[C@]12ON=C(c3cccnc3)[C@H]1[C@@H]1CC[C@H]2C1 CHEMBL5175784 IC50 49.0 nM
O=C1CCc2cc(C(c3ccccc3)n3ccnc3)cc3c2N1CC3 CHEMBL2163649 IC50 50.0 nM
O=c1cc(Cn2ccnc2)c2ccc(OCc3ccc(F)c(F)c3)cc2o1 CHEMBL1688901 IC50 50.0 nM
COc1cc(COc2ccc3c(Cn4ccnc4)cc(=O)oc3c2)cc(OC)c1OC CHEMBL3359958 IC50 50.0 nM
O=[N+]([O-])c1ccc(-c2ccncc2)c(OCc2ccccc2)c1 CHEMBL3421768 IC50 50.0 nM
CC(C)CC1n2cncc2CN(Cc2ccc(Cl)cc2)S1(=O)=O CHEMBL1209553 IC50 50.2 nM
Oc1cncc(Cc2ccc(-c3ccccc3)nc2)c1 CHEMBL2417615 IC50 51.0 nM
Fc1ccc(-c2cccnc2)c(OCCc2ccccc2)c1 CHEMBL3421773 IC50 51.0 nM
O=S(=O)(C1CC1)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4128640 IC50 51.0 nM
CC(=O)N1CCN(c2ccc(/C=C/c3cc(O)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4282398 IC50 51.0 nM
Cc1ccncc1-c1ccc2cc(C#N)ccc2c1 CHEMBL500665 IC50 52.0 nM
CC(=O)N1CCc2cc(-c3cncc4ccccc34)ccc21 CHEMBL3287178 IC50 52.0 nM
N#Cc1ccc(-c2cncc(-c3ccccc3)c2)cc1F CHEMBL5424651 IC50 53.4 nM
O=C1CNc2cc(-c3cncc4ccccc34)ccc2N1 CHEMBL3397603 IC50 54.0 nM
Fc1cc(/C=C/c2ccc(N3CCN(CC4CC4)CC3)cc2)cc(-c2ccncc2)c1 CHEMBL4286910 IC50 54.0 nM
CN1C(=O)CCc2cc(-c3cncc4c3CCCC4O)ccc21 CHEMBL3936459 EC50 54.1 nM
CC(C)CC1n2cncc2CN(Cc2cccs2)S1(=O)=O CHEMBL1209623 IC50 55.7 nM
COc1cncc(-c2ccc(C#N)c(F)c2)c1 CHEMBL5417708 IC50 56.0 nM
COC(=O)CCc1cncn1Cc1ccc(Br)cc1 CHEMBL592614 IC50 57.0 nM
COc1ccc(COc2ccc3c(Cn4ccnc4)cc(=O)oc3c2)cc1OC CHEMBL3359957 IC50 57.0 nM
c1ccc(-c2nscc2Cn2ccnc2)cc1 CHEMBL4099271 IC50 57.0 nM
O=[N+]([O-])c1cc(S(=O)(=O)N2CCN(c3ccc(/C=C/c4cc(Cl)cc(Cn5ccnc5)c4)cc3)CC2)ccc1Cl CHEMBL4293278 IC50 57.0 nM
O=C(Nc1ccc(F)cc1)[C@]12ON=C(c3cccnc3)[C@H]1[C@@H]1CC[C@H]2C1 CHEMBL5171873 IC50 57.0 nM
Fc1ccc2c(c1)CC/C2=C\c1cccc2cnccc12 CHEMBL370530 IC50 58.0 nM
O=C1CCc2cc(-c3cncc(-c4ccccc4)c3)cc3c2N1CC3 CHEMBL1765219 IC50 58.0 nM
O=S(=O)(C1CC1)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3922888 IC50 58.0 nM
Cn1nc(-c2ccccc2)cc1Cn1ccnc1 CHEMBL4101613 IC50 58.0 nM
Cc1cc(C#N)ccc1-c1cnc2n1CCC2 CHEMBL4125850 IC50 58.0 nM
CC(C)S(=O)(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4127256 IC50 58.0 nM
O=c1c(Cc2ccncc2)coc2cc(F)ccc12 CHEMBL3793091 IC50 58.1 nM
CN(C)c1cncc(-c2ccc(C#N)c(F)c2)n1 CHEMBL5418063 IC50 59.3 nM
CC(c1ccc(-c2cccc3ccccc23)nc1)n1ccnc1 CHEMBL2417627 IC50 60.0 nM
O=S(=O)(c1cccs1)N1CCCc2cc(-c3cccnc3)ccc21 CHEMBL3337691 IC50 60.0 nM
Fc1ccc(-c2ccncc2)c(OCCc2ccccc2)c1 CHEMBL3421774 IC50 60.0 nM
Cc1ccccc1Cn1ccnc1 CHEMBL1651492 IC50 61.0 nM
Brc1ncccc1Cn1ccnc1 CHEMBL2011242 IC50 61.0 nM
CC(=O)n1ccc2cc(-c3cnccc3C)ccc21 CHEMBL3287193 IC50 61.0 nM
O=Cc1ccc(-c2ccc(Cn3ccnc3)cn2)s1 CHEMBL2011264 IC50 62.0 nM
O=S(=O)(c1cccc(Cl)c1)N1CCCc2cc(-c3cccnc3)ccc21 CHEMBL3337685 IC50 62.0 nM
c1ccc(-c2ncc(Cn3ccnc3)s2)cc1 CHEMBL4104045 IC50 62.0 nM
CCCOc1ccc(COc2ccc3c(Cn4ccnc4)cc(=O)oc3c2)cc1 CHEMBL3359954 IC50 63.0 nM
CCS(=O)(=O)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3913908 IC50 63.0 nM
COc1ccc2c(c1)CC(C)C(c1cncc3ccccc13)=C2 CHEMBL499044 IC50 64.0 nM
CCC(=O)NC1CCc2c(-c3ccc(Cl)c(F)c3)cncc21 CHEMBL3907799 EC50 64.0 nM
N#Cc1ccc(-c2cncc(-c3cccnc3F)c2)cc1Cl CHEMBL5414558 IC50 64.8 nM
N#Cc1cccc(S(=O)(=O)N2CCCc3cc(-c4cccnc4)ccc32)c1 CHEMBL3337689 IC50 65.0 nM
O=S(=O)(c1ccccc1)N1CCCc2cc(-c3cccnc3)ccc21 CHEMBL3337677 IC50 65.0 nM
O=C(Nc1cccc([N+](=O)[O-])c1)[C@]12ON=C(c3cccnc3)[C@H]1[C@@H]1CC[C@H]2C1 CHEMBL5199220 IC50 65.0 nM
COc1ccc2cc(-c3cncc4ccccc34)ccc2c1 CHEMBL500394 IC50 67.0 nM
CS(=O)(=O)CS(=O)(=O)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3980889 IC50 67.0 nM
O=C1CCc2cc(C(c3ccccc3)c3cccnc3)cc3c2N1CC3 CHEMBL2312968 IC50 68.0 nM
COc1cccc(S(=O)(=O)N(C)c2ccc(-c3cccnc3)cc2)c1 CHEMBL3337673 IC50 68.0 nM
c1ccc(-c2ccc(C(c3ccco3)n3ccnc3)cn2)cc1 CHEMBL2417623 IC50 69.0 nM
N#Cc1ccc(C(c2cc3c4c(c2)CCN4C(=O)CC3)n2ccnc2)cc1 CHEMBL2163648 IC50 70.0 nM
N#CCS(=O)(=O)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3952032 IC50 70.0 nM
CN(C)C(=O)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccccc4Cl)OC3)cc2)CC1 CHEMBL4281307 IC50 70.0 nM
O=c1c2ccccc2oc2cc(Cn3ccnc3)ccc12 CHEMBL350922 IC50 70.8 nM
O=S(=O)(c1cccc(F)c1)N1CCCc2cc(-c3cccnc3)ccc21 CHEMBL3337683 IC50 71.0 nM
OC1CCc2c(-c3ccc(C(F)(F)F)c(F)c3)cncc21 CHEMBL3900969 EC50 71.0 nM
O=c1cc(Cn2ccnc2)c2ccc(OCc3ccccc3)cc2o1 CHEMBL225499 IC50 72.0 nM
Fc1ccccc1-c1ccc(Cn2ccnc2)cn1 CHEMBL2011244 IC50 72.0 nM
Fc1ccc(Cn2ccnc2)cn1 CHEMBL2331707 IC50 72.0 nM
CC(C)(C)OC(=O)COC1CCc2c(-c3ccc(C(F)(F)F)cc3)cncc21 CHEMBL3956843 EC50 72.4 nM
N#Cc1ccc(Cn2cncc2Br)cc1 CHEMBL599223 pIC50 72.44 nM
CN1C(=O)CCc2cc(-c3cncc(COc4ncccc4C(F)(F)F)c3)ccc21 CHEMBL3907972 EC50 72.8 nM
Clc1ncc(Cn2ccnc2)cc1-c1cccs1 CHEMBL2011430 IC50 73.0 nM
Clc1ncc(Cn2ccnc2)cc1-c1ccsc1 CHEMBL3952656 IC50 73.0 nM
N#CCS(=O)(=O)N1CCN(c2ccc(/C=C/c3cc(F)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4125902 IC50 73.0 nM
CCOC(=O)CNC(=O)NC1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4284756 IC50 73.0 nM
c1ccc2c(c1)ncn2CC12CC3CC(CC(C3)C1)C2 CHEMBL1651506 IC50 75.0 nM
c1csc(-c2ccc(Cn3ccnc3)cn2)c1 CHEMBL2011261 IC50 75.0 nM
Cc1cc(Cn2ccnc2)c2ccc3[nH]ccc3c2n1 CHEMBL2442759 IC50 75.0 nM
CC(C)CC1n2cncc2CN([C@@H](C)c2ccc(Cl)cc2)S1(=O)=O CHEMBL1209625 IC50 76.0 nM
c1cn(Cc2ccc(-c3ccoc3)nc2)cn1 CHEMBL2011435 IC50 76.0 nM
Oc1cncc(Cc2cnc(-c3ccccc3)s2)c1 CHEMBL4280014 IC50 77.0 nM
O=C1CCc2cc(C(c3ccc(F)cc3)c3cccnc3)cc3c2N1CC3 CHEMBL2312972 IC50 78.0 nM
COc1ccc2c(=O)c(Cn3ccnc3)c(-c3ccccc3)oc2c1 CHEMBL158635 IC50 79.0 nM
COc1ccc(NC(=O)[C@]23ON=C(c4cccnc4)[C@H]2[C@@H]2CC[C@H]3C2)cc1 CHEMBL5197879 IC50 79.0 nM
c1ccc(C(CCn2ccnc2)(c2ccccc2)c2ccccc2)cc1 CHEMBL1651509 IC50 80.0 nM
COc1ccc(COc2ccc3c(Cn4ccnc4)cc(=O)oc3c2)cc1 CHEMBL1688898 IC50 80.0 nM
COc1ccc(Cn2ccnc2)c2c(=O)c3ccccc3oc12 CHEMBL2333329 IC50 80.1 nM
COc1cc2ccccc2cc1-n1ccnc1 CHEMBL194472 IC50 81.0 nM
CC(=O)N[C@@H]1CCCc2c1cncc2N1C(=O)c2ccc(Cl)cc2[C@@H]1C CHEMBL4645158 IC50 81.0 nM
O=S(=O)(c1cccs1)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3960724 IC50 82.0 nM
O=c1cc(Cc2ccncc2)oc2cc(F)ccc12 CHEMBL3794417 IC50 82.7 nM
O=C(Nc1ccc(Cl)cc1)[C@]12ON=C(c3cccnc3)[C@H]1[C@@H]1CC[C@H]2C1 CHEMBL5197102 IC50 83.0 nM
CCN(C)c1cncc(-c2ccc(C#N)c(F)c2)n1 CHEMBL5408774 IC50 85.8 nM
O=C(Nc1cccc(F)n1)[C@]12ON=C(c3cccnc3)[C@H]1[C@@H]1CC[C@H]2C1 CHEMBL5185819 IC50 86.0 nM
O=c1c(Cn2ccnc2)coc2cc(F)ccc12 CHEMBL3793904 IC50 86.9 nM
C(=C1/CCc2ccccc21)\c1cccnc1 CHEMBL363621 IC50 87.0 nM
COc1cncc(-c2ccc3c(c2)CCC(=O)N3C)c1 CHEMBL457856 IC50 87.0 nM
c1ccc(-c2ncc(Cn3ccnc3)c3ccccc23)cc1 CHEMBL2417632 IC50 87.0 nM
O=C1CCc2cc(C(c3ccncc3)c3ccc(F)cc3)cc3c2N1CC3 CHEMBL2312959 IC50 88.0 nM
O=c1c(Cc2ccncc2)coc2ccccc12 CHEMBL3794430 IC50 88.2 nM
CC(=O)c1cncc(-c2ccc(C#N)c(F)c2)c1 CHEMBL5396680 IC50 91.7 nM
O=C1CCc2cc(C(c3ccncc3)c3ccc(Cl)cc3)cc3c2N1CC3 CHEMBL2312961 IC50 92.0 nM
CC(C)Oc1ccc(Cn2ccnc2)c2c(=O)c3ccccc3oc12 CHEMBL2333331 IC50 92.5 nM
OC(c1ccccc1)c1cncnc1Nc1ccc(F)cc1 CHEMBL4065476 IC50 93.0 nM
c1ccc2c(-c3ccc(Cn4ccnc4)cn3)cncc2c1 CHEMBL2011260 IC50 95.0 nM
C/C(=C1/CCc2cc(F)ccc21)c1cccnc1 CHEMBL194047 IC50 96.0 nM
O=C(Nc1ccc([N+](=O)[O-])cc1)[C@]12ON=C(c3cccnc3)[C@H]1[C@@H]1CC[C@H]2C1 CHEMBL5202317 IC50 96.0 nM
O=C(Nc1cccc(Cl)c1)[C@]12ON=C(c3cccnc3)[C@H]1[C@@H]1CC[C@H]2C1 CHEMBL5202486 IC50 97.0 nM
c1ccc(-c2ccc(Cc3ccncc3)cn2)cc1 CHEMBL2417634 IC50 98.0 nM
CC(C)(O)c1cncc(-n2ncc3c(C(F)(F)F)cccc32)c1 CHEMBL4067000 IC50 98.0 nM
COc1ccc2cc(-c3cncc(C(C)O)c3)ccc2c1 CHEMBL500395 IC50 99.0 nM
O=c1c2ccccc2oc2cccc(Cn3ccnc3)c12 CHEMBL1083652 IC50 99.1 nM