Fc1ccc2c(c1)CC/C2=C/c1cncnc1 CHEMBL364956 IC50 0.0 nM
Cc1cccc(SCc2cncc(-c3ccc4c(c3)CCC(=O)N4C)c2)n1 CHEMBL3916961 EC50 0.012 nM
CN1C(=O)CCc2cc(-c3cncc4ccccc34)ccc21 CHEMBL451505 IC50 0.1 nM
CCOC(=O)c1cncn1[C@H](C)c1ccccc1 CHEMBL681 IC50 0.1 nM
CCOC(=O)c1cncn1C(C)c1ccccc1 CHEMBL23731 IC50 0.1 nM
Cc1cccc(OCc2cncc(-c3ccc4c(c3)CCC(=O)N4C)c2)n1 CHEMBL3923975 EC50 0.1 nM
Cc1ccnc(OCc2cncc(-c3ccc4c(c3)CCC(=O)N4C)c2)c1 CHEMBL3911527 EC50 0.1 nM
CN1C(=O)CCc2cc(-c3cncc(COc4ccc(Cl)cn4)c3)ccc21 CHEMBL3969143 EC50 0.1 nM
Cc1nccc(OCc2cncc(-c3ccc4c(c3)CCC(=O)N4C)c2)n1 CHEMBL3939497 EC50 0.1 nM
CN1C(=O)CCc2cc(-c3cncc(COc4cnc(Cl)nc4)c3)ccc21 CHEMBL3930515 EC50 0.1 nM
CN1C(=O)CCc2cc(-c3cncc(COc4ccc(Cl)cn4)c3)c(F)cc21 CHEMBL3959070 EC50 0.1 nM
Cc1ccnc(OCc2cncc(-c3cc4c(cc3F)N(C)C(=O)CC4)c2)c1 CHEMBL3986059 EC50 0.1 nM
Cn1c(-c2cncc3ccccc23)nc2ccc(F)c(F)c21 CHEMBL3313977 IC50 0.15 nM
COc1ccc2cc(-c3cncc(C(C)OC)c3)ccc2c1 CHEMBL500392 IC50 0.2 nM
COCc1cncc(-c2ccc3cc(OC)ccc3c2)c1 CHEMBL500421 IC50 0.2 nM
COc1cncc(-c2ccc3c(c2)CCC(=O)N3C)c1 CHEMBL457856 IC50 0.2 nM
O=C1CCc2cc(-c3cncc4ccccc34)ccc2N1 CHEMBL456390 IC50 0.2 nM
O=C1CCc2cc(-c3cncc4ccccc34)cc3c2N1CC3 CHEMBL1765214 IC50 0.2 nM
O=C1CCc2cc(-c3cncc4ccccc34)cc3c2N1CCC3 CHEMBL1765215 IC50 0.2 nM
N#Cc1ccc([C@H]2CCc3cncn32)c(F)c1 CHEMBL3099695 IC50 0.2 nM
Cc1cncc(-c2nc3cc(F)c(F)cc3n2C2CC2)c1C CHEMBL3582482 IC50 0.2 nM
CC1(COC2CCc3c(-c4ccc(C(F)(F)F)cc4)cncc32)COC1 CHEMBL3981240 EC50 0.2 nM
CN1C(=O)CCc2cc(-c3cncc(COc4cccc(Cl)n4)c3)ccc21 CHEMBL3897028 EC50 0.2 nM
CN1C(=O)CCc2cc(-c3cncc(COc4ccc(F)cn4)c3)ccc21 CHEMBL3948274 EC50 0.2 nM
CN1C(=O)CCc2cc(-c3cncc(COc4ccccn4)c3)ccc21 CHEMBL3936019 EC50 0.2 nM
CN1C(=O)CCc2cc(-c3cncc(COc4cc(C#N)ccn4)c3)ccc21 CHEMBL3890700 EC50 0.2 nM
Cc1c(COc2cccc(F)n2)cncc1-c1cc2c(cc1F)N(C)C(=O)CC2 CHEMBL3984990 EC50 0.2 nM
CC(C)(O)c1cncc(-n2ncc3c(Cl)ccc(F)c32)c1 CHEMBL4096914 IC50 0.2 nM
C[C@@H](c1ccc(Cl)cc1)N1Cc2cncn2C(C[C@H](O)c2ccccc2)S1(=O)=O CHEMBL1209696 IC50 0.3 nM
O=C1Nc2ccc(-c3cncc4ccccc34)cc2CO1 CHEMBL3397605 IC50 0.3 nM
CC(C)(O)c1cncc(-c2nc3cc(F)c(F)cc3n2C2CC2)c1 CHEMBL3582477 IC50 0.3 nM
CN1C(=O)CCc2cc(-c3cncc(COc4ccnc(C(F)(F)F)n4)c3)ccc21 CHEMBL3902519 EC50 0.3 nM
CN1C(=O)CCc2cc(-c3cncc(CSc4nc5ccccc5o4)c3)ccc21 CHEMBL3982418 EC50 0.3 nM
CN1C(=O)CCc2cc(-c3cncc(COc4cccc(F)n4)c3)ccc21 CHEMBL3950364 EC50 0.3 nM
CN1C(=O)CCc2cc(-c3cncc(COc4cccc(Cl)n4)c3)c(F)cc21 CHEMBL3928063 EC50 0.3 nM
CC(C)(O)c1cncc(-n2ncc3c(F)ccc(F)c32)c1 CHEMBL4069720 IC50 0.3 nM
CC1(c2cncc(-c3ccc(C#N)c(F)c3)c2)OCCO1 CHEMBL5406728 IC50 0.3 nM
N#Cc1ccc([C@H]2CCCCc3cncn32)c(-c2ccc(F)cc2)c1 CHEMBL3099704 IC50 0.4 nM
COc1cncc(-c2nc3cc(F)c(F)cc3n2C2CC2)c1 CHEMBL3582474 IC50 0.4 nM
Fc1cc2nc(-c3cccnc3)n(C3CC3)c2cc1Cl CHEMBL3582470 IC50 0.4 nM
Cc1cc(OCc2cncc(-c3ccc4c(c3)CCC(=O)N4C)c2)nc(C(F)(F)F)c1 CHEMBL3896815 EC50 0.4 nM
CS(=O)(=O)N1CCC(C(O)c2cncnc2Sc2ccc(F)cc2)CC1 CHEMBL4088766 IC50 0.4 nM
COc1ccc2c(c1)CC(C)C(c1cncc3ccccc13)=C2 CHEMBL499044 IC50 0.5 nM
COc1ccc2cc(-c3cncc(C(C)O)c3)ccc2c1 CHEMBL500395 IC50 0.5 nM
c1ccc(-c2cncc(Cc3ccc(-c4ccccc4)nc3)c2)cc1 CHEMBL2417616 IC50 0.5 nM
O=C1COc2cc(-c3cncc4ccccc34)ccc2N1 CHEMBL3397600 IC50 0.5 nM
Cc1c(F)cncc1-c1nc2cc(F)c(F)cc2n1C1CC1 CHEMBL3582481 IC50 0.5 nM
CN1C(=O)CCc2cc(-c3cncc(CSc4ncccc4C(F)(F)F)c3)ccc21 CHEMBL3944873 EC50 0.5 nM
Cn1cc(C(=O)N2CC(Oc3cncc(N4C(=O)c5ccc(Cl)cc5C4(C)C)c3)C2)cn1 CHEMBL4635011 IC50 0.5 nM
Cc1ccncc1-c1ccc2cc(C#N)ccc2c1 CHEMBL500665 IC50 0.6 nM
COc1ccc2cc(-c3cncc4ccccc34)ccc2c1 CHEMBL500394 IC50 0.6 nM
COc1cncc(-c2cc3c4c(c2)CCN4C(=O)CC3)c1 CHEMBL1765207 IC50 0.6 nM
CC(=O)n1ccc2cc(-c3cncc4ccccc34)ccc21 CHEMBL3287192 IC50 0.6 nM
COc1c(C)cncc1-c1nc2cc(F)c(F)cc2n1C1CC1 CHEMBL3582483 IC50 0.6 nM
N#Cc1cc2c(cc1F)nc(-c1cccnc1)n2C1CC1 CHEMBL3582471 IC50 0.6 nM
Fc1ccc2nc(-c3cncc4ccccc34)c(C3CC3)n2c1 CHEMBL3948337 IC50 0.6 nM
O=C1CCc2cc(-c3cncc(-c4ccccc4F)c3)cc3c2N1CC3 CHEMBL1765220 IC50 0.7 nM
CC(=O)N1CCc2cc(-c3cncc4ccccc34)ccc21 CHEMBL3287178 IC50 0.7 nM
Cc1cccc(OCc2cncc(-c3cc4c(cc3F)N(C)C(=O)CC4)c2C)n1 CHEMBL3904594 EC50 0.7 nM
CS(=O)(=O)N1CCC(C(O)(c2cncnc2Nc2ccc(F)cc2)C(F)(F)F)CC1 CHEMBL4082403 IC50 0.73 nM
CCN(CC)c1cncc(-c2ccc(C#N)c(F)c2)n1 CHEMBL5439285 IC50 0.75 nM
COc1ccc2cc(-c3cnccc3C)ccc2c1 CHEMBL500664 IC50 0.8 nM
COC(=O)c1cncc(-c2ccc3cc(OC)ccc3c2)c1 CHEMBL500146 IC50 0.8 nM
CC(C)OCC1n2cncc2CN([C@@H](C)c2ccc(Cl)cc2)S1(=O)=O CHEMBL1209694 IC50 0.8 nM
N#Cc1ccc(C2CCCc3cncn32)cc1 CHEMBL9298 IC50 0.8 nM
Fc1cncc(-c2nc3cc(F)c(Cl)cc3n2C2CC2)c1 CHEMBL3582475 IC50 0.8 nM
COC(C)(C)CC1n2cncc2CN([C@@H](C)c2ccc(Cl)cc2)S1(=O)=O CHEMBL1209693 IC50 0.9 nM
COc1cncc(-c2cc3c4c(c2)CCC(=O)N4CCC3)c1 CHEMBL1765208 IC50 0.9 nM
O=C1CCc2cc(-c3cncc(-c4ccc(F)cc4)c3)cc3c2N1CC3 CHEMBL1765222 IC50 0.9 nM
Cc1cc(C#N)ccc1[C@H]1CCc2cncn21 CHEMBL3099696 IC50 0.9 nM
CC(C)(O)c1cncc(-n2ncc3cccc(F)c32)c1 CHEMBL4075377 IC50 0.9 nM
CC1COC(c2cncc(-c3ccc(C#N)c(F)c3)c2)O1 CHEMBL5396904 IC50 0.94 nM
CN(C)c1cncc(-c2ccc(C#N)c(F)c2)n1 CHEMBL5418063 IC50 0.94 nM
CCOc1cncc(-c2cc3c4c(c2)CCN4C(=O)CC3)c1 CHEMBL1765209 IC50 1.0 nM
N#Cc1cc2c(cc1F)nc(-c1cncc(F)c1)n2C1CC1 CHEMBL3582476 IC50 1.0 nM
N#Cc1ccc(-c2cncc(C3OCCO3)c2)cc1F CHEMBL5413320 IC50 1.0 nM
O=C1CCc2cc(-c3cccnc3)cc3c2N1CC3 CHEMBL1765205 IC50 1.1 nM
O=C1CNc2cc(-c3cncc4ccccc34)ccc2N1 CHEMBL3397603 IC50 1.1 nM
CCS(=O)(=O)NCc1cncc(-c2cc3ccc(Cl)nc3n2C)c1 CHEMBL3746080 IC50 1.1 nM
NC(=O)COC1CCc2c(-c3ccc(C(F)(F)F)cc3)cncc21 CHEMBL3897910 EC50 1.1 nM
N#Cc1ccc(-c2cncc(-c3ccc(F)cc3)c2)cc1F CHEMBL5402622 IC50 1.1 nM
COc1cncc(C2=Cc3ccc(OC)cc3CC2C)c1 CHEMBL500145 IC50 1.2 nM
O=C1CCc2cc(-c3cncc(-c4cccc(O)c4)c3)cc3c2N1CC3 CHEMBL1765229 IC50 1.2 nM
S=C1CCc2cc(-c3cccnc3)cc3c2N1CC3 CHEMBL1765232 IC50 1.2 nM
N#Cc1ccc2nc(-c3cccnc3)n(C3CC3)c2c1 CHEMBL3582467 IC50 1.2 nM
Cc1c(-c2cncc(C(C)(C)O)c2)nc2ccc(F)cn12 CHEMBL3968397 IC50 1.2 nM
CC(C)(O)c1cncc(-c2nc3ccc(F)cn3c2Cl)c1 CHEMBL3976931 IC50 1.2 nM
C[C@@H](c1ccc(Cl)cc1)N1Cc2cncn2C(CC2CC2)S1(=O)=O CHEMBL1208801 IC50 1.3 nM
O=C1CCc2cc(-c3cncc(-c4ccccc4)c3)cc3c2N1CC3 CHEMBL1765219 IC50 1.3 nM
N#Cc1ccc(-c2cncc3c2CCC3O)cc1 CHEMBL3975309 EC50 1.3 nM
Cc1c(COc2cccc(Cl)n2)cncc1-c1cc2c(cc1F)N(C)C(=O)CC2 CHEMBL3978582 EC50 1.3 nM
Cc1nn(-c2cncc(C(C)(C)O)c2)c2cccc(F)c12 CHEMBL4080420 IC50 1.3 nM
O=C1CCc2cc(-c3cncc(-c4cccc(F)c4)c3)cc3c2N1CC3 CHEMBL1765221 IC50 1.4 nM
COc1ccc(-c2cncc(-c3cc4c5c(c3)CCN5C(=O)CC4)c2)cc1 CHEMBL1765228 IC50 1.4 nM
Cn1c(=O)oc2cc(-c3cncc(C(O)C(F)(F)F)c3)ccc21 CHEMBL3313968 IC50 1.4 nM
Cc1c(-c2cccnc2)n(C)c2ccccc12 CHEMBL3747584 IC50 1.4 nM
CC(C)(O)c1cncc(-c2nc3ccc(F)cc3n2C2CC2)c1 CHEMBL3582478 IC50 1.4 nM
CC(C)(C)OC(=O)COC1CCc2c(-c3ccc(C(F)(F)F)cc3)cncc21 CHEMBL3956843 EC50 1.4 nM
CN1C(=O)CCc2cc(-c3cncc(CSc4ncccc4Cl)c3)ccc21 CHEMBL3973445 EC50 1.4 nM
N#Cc1ccc([C@@]2(C(=O)OCc3ccc(F)cc3)CCc3cncn32)c(Cl)c1 CHEMBL3099689 IC50 1.5 nM
N#Cc1ccc(-c2cncc(N3CCCC3)n2)cc1F CHEMBL5400111 IC50 1.5 nM
N#CC1=Cc2ccc(-c3cccnc3)cc2CC1 CHEMBL461884 IC50 1.6 nM
N#Cc1ccc([C@H]2CCCc3cncn32)cc1 CHEMBL287677 IC50 1.6 nM
N#Cc1ccc(Cn2cncc2-c2ccccc2)cc1 CHEMBL597578 pIC50 1.698 nM
CC(=O)n1ccc2cc(-c3cnccc3C)ccc21 CHEMBL3287193 IC50 1.7 nM
N#Cc1ccc(-c2cncc(-c3ccccc3F)c2)cc1F CHEMBL5415328 IC50 1.7 nM
COc1cncc(-c2ccc3c(c2)CCC(=O)C3)c1 CHEMBL499007 IC50 1.8 nM
CCOc1cncc(-c2ccc(C#N)c(F)c2)c1 CHEMBL5409957 IC50 1.9 nM
COc1ccc2c(c1)CCC(c1cccnc1)=C2 CHEMBL206351 IC50 2.0 nM
c1ccc(-c2ccccc2[C@H]2CCCCc3cncn32)cc1 CHEMBL3099682 IC50 2.0 nM
Fc1ccc(-c2ccccc2[C@H]2CCCCc3cncn32)cc1 CHEMBL3099604 IC50 2.0 nM
CC1CCCC(c2ccc(C#N)cc2-c2ccc(F)cc2)n2cncc21 CHEMBL3313971 IC50 2.0 nM
CN(C)S(=O)(=O)Oc1cncc(-c2c(C#N)c3ccccc3n2C)c1 CHEMBL3746175 IC50 2.0 nM
Cc1ccncc1-c1cnc2c(c1)CCCN2C(N)=O CHEMBL3953785 IC50 2.0 nM
Cc1cncc(-c2cnc3c(c2)CCCN3C(N)=O)c1 CHEMBL3960079 IC50 2.0 nM
CCC(=O)N[C@H]1CCc2c(-c3ccc(F)c(C)c3)cncc21 CHEMBL3922461 EC50 2.0 nM
CN1C(=O)CCc2cc(-c3cncc4c3CCCC4O)ccc21 CHEMBL3936459 EC50 2.0 nM
Cc1cccc(OCc2cncc(-c3cc4c(cc3F)N(C)C(=O)CC4)c2)n1 CHEMBL3952507 EC50 2.0 nM
CS(=O)(=O)N1CCC(C(O)c2cncnc2Nc2ccc(C#N)cc2)CC1 CHEMBL4070230 IC50 2.0 nM
CC(O)(c1cncnc1Nc1ccc(F)cc1)C1CCN(S(C)(=O)=O)CC1 CHEMBL4070323 IC50 2.0 nM
CC(O)(c1cncc(-n2ncc3cc(F)ccc32)c1)C(F)(F)F CHEMBL4101709 IC50 2.0 nM
CC1(C)c2cc(Cl)ccc2C(=O)N1c1cncc(N2CCN(S(C)(=O)=O)CC2)c1 CHEMBL4635517 IC50 2.0 nM
Cn1cc(C(=O)N2CC3(C2)CN(c2cncc(N4C(=O)c5ccc(Cl)cc5C4(C)C)c2)C3)cn1 CHEMBL4641359 IC50 2.0 nM
COc1ccc2cc(-c3cncc(C(C)=O)c3)ccc2c1 CHEMBL502824 IC50 2.1 nM
Fc1cc2nc(-c3cccnc3)n(C3CC3)c2cc1F CHEMBL3582469 IC50 2.1 nM
COCc1ccncc1-c1ccc2cc(OC)ccc2c1 CHEMBL500676 IC50 2.2 nM
CC(C)Oc1cncc(-c2cc3c4c(c2)CCN4C(=O)CC3)c1 CHEMBL1765210 IC50 2.2 nM
CC(=O)N1CCc2cc(-c3cnccc3C)ccc21 CHEMBL3287188 IC50 2.2 nM
Cc1cncc(-c2cc3n(n2)CCC(=O)N3)c1 CHEMBL3313978 IC50 2.2 nM
O=C1NCc2cc(-c3cncc4ccccc34)ccc2N1 CHEMBL3397607 IC50 2.2 nM
Cc1nnc2n1-c1c(F)cc(-c3cncc4ccccc34)cc1CC2 CHEMBL3415172 IC50 2.2 nM
Clc1ccc2nc(-c3cccnc3)n(C3CC3)c2c1 CHEMBL3582465 IC50 2.2 nM
CC1(C)Cc2c(-c3ccc(C#N)cc3)cncc2C1O CHEMBL3951086 EC50 2.2 nM
Cc1cncc(-c2nn3c(c2C)NC(=O)CC3)c1 CHEMBL3983243 IC50 2.2 nM
Cc1cccc(NC(=O)Cc2cncc(-c3ccc4c(c3)CCC(=O)N4C)c2)n1 CHEMBL3960269 EC50 2.2 nM
CC(C)(O)c1cncc(-n2ncc3c(C(F)(F)F)cccc32)c1 CHEMBL4067000 IC50 2.2 nM
Cc1cc(C#N)ccc1-c1cnn2c1C[C@@H](Oc1cnccn1)C2 CHEMBL4126893 IC50 2.2 nM
Cc1cc(C#N)ccc1-c1cnn2c1C[C@@H](Oc1ncc(C#N)cn1)C2 CHEMBL4127675 IC50 2.2 nM
CCN(C)c1cncc(-c2ccc(C#N)c(F)c2)n1 CHEMBL5408774 IC50 2.2 nM
N#Cc1ccc(Cn2cncc2-c2ccccc2F)cc1 CHEMBL599603 pIC50 2.291 nM
O=C1CCc2cc(-c3cncc(-c4ccc(F)c(F)c4)c3)cc3c2N1CC3 CHEMBL1765224 IC50 2.3 nM
CN1C(=O)CCc2cc(-c3cncc(COc4ncccc4C(F)(F)F)c3)ccc21 CHEMBL3907972 EC50 2.3 nM
Cc1cc(C#N)ccc1-c1cnn2c1C[C@@H](OCc1ccccc1)C2 CHEMBL4127904 IC50 2.3 nM
COc1cncc(-c2ccc(C#N)c(F)c2)c1 CHEMBL5417708 IC50 2.3 nM
C[C@@H](c1ccc(Cl)cc1)N1Cc2cncn2C(C[C@@H](O)c2ccccc2)S1(=O)=O CHEMBL1209695 IC50 2.4 nM
O=C1CCc2cc(-c3cccnc3)cc3c2N1CCC3 CHEMBL1765206 IC50 2.4 nM
COc1ccccc1-c1cncc(-c2cc3c4c(c2)CCN4C(=O)CC3)c1 CHEMBL1765226 IC50 2.4 nM
CC(C)CC1n2cncc2CN(Cc2ccc(F)cc2)S1(=O)=O CHEMBL1209476 IC50 2.5 nM
CC(O)c1c(F)cncc1-c1cc2cc(Cl)c(F)cc2o1 CHEMBL3313967 IC50 2.5 nM
Cn1c(-c2cccnc2)c(C#N)c2ccc(Cl)cc21 CHEMBL3747269 IC50 2.5 nM
COC(=O)c1cncc(-c2nc3ccc(F)cn3c2C2CC2)c1 CHEMBL3930836 IC50 2.5 nM
Cc1cc(C#N)ccc1-c1cnc2n1CCC2 CHEMBL4125850 IC50 2.5 nM
CC(C)Oc1cncc(-c2ccc(C#N)c(F)c2)c1 CHEMBL5424502 IC50 2.5 nM
CN1C(=O)CCc2cc(-c3cccnc3)ccc21 CHEMBL446083 IC50 2.6 nM
NC(=O)N1CCCc2cc(-c3cncc(C(O)C(F)(F)F)c3)cnc21 CHEMBL3906375 IC50 2.6 nM
N#Cc1ccc(Cc2cc3ccccc3cc2-c2cccnc2)cc1 CHEMBL524011 IC50 2.7 nM
COc1cncc(-c2ccc3c(c2)CCC(=O)N3)c1 CHEMBL457646 IC50 2.7 nM
NC(=O)N1CCCc2cc(-c3cncc(-c4ccc(S(N)(=O)=O)cc4)c3)cnc21 CHEMBL3971477 IC50 2.7 nM
CCC(=O)N1CCc2cc(-c3cncc4ccccc34)ccc21 CHEMBL3287179 IC50 2.8 nM
CC1(C)c2cc(Cl)ccc2C(=O)N1c1cncc(C2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3313982 IC50 2.8 nM
N#Cc1ccc2cc(-c3cccnc3)ccc2c1 CHEMBL196796 IC50 2.9 nM
Cc1cncc(-c2ccc(C#N)c(F)c2)c1 CHEMBL5413659 IC50 2.9 nM
COc1ccc2c(c1)/C(=C/c1ccncc1)CC2 CHEMBL365314 IC50 3.0 nM
C(=C1\CC(c2ccccc2)c2ccccc21)\c1cccnc1 CHEMBL193555 IC50 3.0 nM
COc1ccc(Cc2cc3ccccc3cc2-c2cncc3ccccc23)cc1 CHEMBL522860 IC50 3.0 nM
O=c1c2ccccc2oc2c(Cl)ccc(Cn3ccnc3)c12 CHEMBL2333326 IC50 3.0 nM
COC(=O)[C@]1(c2ccc(C#N)cc2OC)CCc2cncn21 CHEMBL3099687 IC50 3.0 nM
CC(=O)N1CCc2cc(-c3cncc(-c4ccccc4)c3)ccc21 CHEMBL3287187 IC50 3.0 nM
CCOC(=O)c1cncn1C1c2ccccc2C(=O)OC1(C)C CHEMBL3313975 IC50 3.0 nM
Cc1c(-c2cccnc2)[nH]c2ccccc12 CHEMBL3746125 IC50 3.0 nM
CCC(=O)NC1CCCc2c(-c3ccc(Cl)c(Cl)c3)cncc21 CHEMBL3953653 EC50 3.0 nM
CS(=O)(=O)N1CCC(C(O)c2cncnc2Nc2ccc(C(F)(F)F)cc2)CC1 CHEMBL4091167 IC50 3.0 nM
CS(=O)(=O)N1CCC(C(O)c2cncnc2Nc2ccc(F)cc2)CC1 CHEMBL4099824 IC50 3.0 nM
Fc1cc2nc(-c3cncnc3NCCC(F)(F)F)n(C3CC3)c2cc1F CHEMBL4528905 IC50 3.0 nM
CCS(=O)(=O)N1CCC(c2cncc(N3C(=O)c4ccc(Cl)cc4C3(C)C)c2)CC1 CHEMBL4642895 IC50 3.0 nM
COc1ccc2cc(-c3cncc4ccccc34)c(C)cc2c1 CHEMBL525785 IC50 3.1 nM
S=C1CCc2cc(-c3cccnc3)ccc2N1 CHEMBL511329 IC50 3.1 nM
NC(=O)N1CCCc2cc(-c3cnccc3F)cnc21 CHEMBL3942729 IC50 3.1 nM
N#Cc1c(Cl)cncc1-c1cnc2c(c1)CCCN2C(N)=O CHEMBL3952190 IC50 3.1 nM
CC1(C)Cc2c(-c3ccc(C(F)(F)F)c(F)c3)cncc2C1O CHEMBL3928758 EC50 3.1 nM
N#Cc1ccc([C@H]2CCCCc3cncn32)c(F)c1 CHEMBL3099683 IC50 3.2 nM
Cc1ccncc1-c1cnc2c(c1)CCN2C(N)=O CHEMBL3967734 IC50 3.2 nM
NC(=O)N1CCc2cc(-c3cnccc3C(F)(F)F)cnc21 CHEMBL3924458 IC50 3.2 nM
CO[C@@H]1Cc2c(-c3ccc(C#N)cc3C)cnn2C1 CHEMBL4129296 IC50 3.2 nM
COc1ccc2c(c1)CC(C)C(c1cccnc1)=C2 CHEMBL502266 IC50 3.3 nM
COC1CCc2cc(-c3cccnc3)ccc2C1 CHEMBL460178 IC50 3.3 nM
Cc1cncc(-c2nc3ccc(F)cn3c2C2CC2)c1 CHEMBL3911595 IC50 3.3 nM
N#CCc1ccc(-c2cncc(-c3cnc4c(c3)CCCN4C(N)=O)c2)cc1 CHEMBL3945692 IC50 3.3 nM
N#Cc1ccc(-c2cncc(-c3cccnc3F)c2)cc1Cl CHEMBL5414558 IC50 3.4 nM
COC(=O)CCc1cncn1Cc1ccc(C#N)cc1 CHEMBL591229 pIC50 3.467 nM
NC(=O)N1CCCc2cc(-c3cncc(NCc4ccccc4)c3)cnc21 CHEMBL3962673 IC50 3.5 nM
O=C1CCc2cc(-c3cncc(-c4cc(F)ccc4F)c3)cc3c2N1CC3 CHEMBL1765223 IC50 3.6 nM
COc1cncc(-c2cnc3c(c2)CCCN3C(N)=O)c1 CHEMBL3918302 IC50 3.6 nM
N#CCc1cccc(-c2cncc(-c3cnc4c(c3)CCCN4C(N)=O)c2)c1 CHEMBL3937454 IC50 3.6 nM
CN1C(=O)CCc2cc(-c3cncc(COc4ncccn4)c3)ccc21 CHEMBL3907745 EC50 3.6 nM
Clc1ccc2c(c1)CC/C2=C/c1c[nH]cn1 CHEMBL175688 IC50 3.7 nM
Cc1ccccc1-c1cncn1Cc1ccc(C#N)cc1 CHEMBL610513 IC50 3.7 nM
CCS(=O)(=O)NCc1cncc(-c2c(C#N)c3ccc(Cl)cc3n2C)c1 CHEMBL3747562 IC50 3.7 nM
N#CC1(c2cncc(-c3cnc4c(c3)CCCN4C(N)=O)c2)CC1 CHEMBL3972323 IC50 3.7 nM
Cc1cc(C#N)ccc1-c1cnn2c1CCC2 CHEMBL4128315 IC50 3.7 nM
COc1cncc(-c2cc3ccc(OC)cc3cc2C)c1 CHEMBL502818 IC50 3.8 nM
O=C1CCc2cc(-c3cccnc3)cc(Cl)c2N1 CHEMBL457640 IC50 3.8 nM
CC(C)C(c1cc2c3c(c1)CCN3C(=O)CC2)n1ccnc1 CHEMBL2163638 IC50 3.8 nM
CCC(=O)NC1CCc2c(-c3cc4c(cc3F)N(C)C(=O)CC4)cncc21 CHEMBL3977374 EC50 3.8 nM
Fc1cc(-c2cncc(C3OCCO3)c2)ccc1C(F)(F)F CHEMBL5412612 IC50 3.8 nM
CSc1cncc(-c2ccc(C#N)c(F)c2)c1 CHEMBL5408597 IC50 3.8 nM
FC(F)(F)Oc1ccc(Cc2cc3ccccc3cc2-c2cccnc2)cc1 CHEMBL494712 IC50 3.9 nM
COC(=O)CCc1cncn1Cc1ccc(Br)cc1 CHEMBL592614 pIC50 3.981 nM
Cc1ccc2c(c1)/C(=C/c1ccncc1)CC2 CHEMBL371742 IC50 4.0 nM
COc1ccc2c(c1)C=C(c1cccnc1)C2 CHEMBL206300 IC50 4.0 nM
Fc1ccc2nc(-c3cccnc3)n(C3CC3)c2c1 CHEMBL3582451 IC50 4.0 nM
COc1cncc(-c2nc3ccc(F)cn3c2C2CC2)c1 CHEMBL3930572 IC50 4.0 nM
CS(=O)(=O)c1ccc(-c2cncc(-c3cnc4c(c3)CCCN4C(N)=O)c2)cc1 CHEMBL3900640 IC50 4.0 nM
CCC(=O)NC1CCCc2c(-c3ccc(F)c(C)c3)cncc21 CHEMBL3893227 EC50 4.0 nM
COc1ccc2c(c1)CC(c1cccnc1)=C2 CHEMBL3950454 IC50 4.0 nM
CN1C(=O)CCc2cc(-c3cncc4c3CCCN4CCN)ccc21 CHEMBL3974493 EC50 4.0 nM
Cc1cc(C#N)ccc1-c1cnn2c1C[C@@H](Oc1ncccn1)C2 CHEMBL4129177 IC50 4.0 nM
CC(=O)N[C@@H]1CCCc2c1cncc2N1C(=O)c2ccc(Cl)cc2[C@@H]1C CHEMBL4645158 IC50 4.0 nM
CCS(=O)(=O)N1CC(Oc2cncc(N3C(=O)c4ccc(Cl)cc4C3(C)C)c2)C1 CHEMBL4647543 IC50 4.0 nM
CC(=O)N1CCC(Oc2cncc(N3C(=O)c4ccc(Cl)cc4C3(C)C)c2)CC1 CHEMBL4646980 IC50 4.0 nM
Cc1ccncc1C(=O)N1CC(Oc2cncc(N3C(=O)c4ccc(Cl)cc4C3(C)C)c2)C1 CHEMBL4642138 IC50 4.0 nM
NC(=O)N1CCCc2cc(-c3cncc(C4CC4)c3)cnc21 CHEMBL3953880 IC50 4.1 nM
COc1cncc(-c2ccc3cc(OC)ccc3c2)c1 CHEMBL447591 IC50 4.2 nM
S=C1CCc2cc(-c3cccnc3)cc(Cl)c2N1 CHEMBL508155 IC50 4.2 nM
O=C1CCc2cc(C(C3CCC3)n3ccnc3)cc3c2N1CC3 CHEMBL2163640 IC50 4.2 nM
Cc1ccncc1-c1cc(F)c2c(c1)CCc1nnc(C)n1-2 CHEMBL3313969 IC50 4.2 nM
Cc1cnc(O[C@@H]2Cc3c(-c4ccc(C#N)cc4C)cnn3C2)nc1 CHEMBL4125736 IC50 4.2 nM
O=C1CCc2cc(-c3cncc(O)c3)cc3c2N1CC3 CHEMBL1765211 IC50 4.3 nM
NC(=O)N1CCCc2cc(-c3cncc(COCC(=O)N4CCCCC4)c3)cnc21 CHEMBL3960988 IC50 4.3 nM
O=C1CCc2cc(-c3cccnc3)ccc21 CHEMBL448743 IC50 4.4 nM
O=C1CCc2cc(-c3cncc(F)c3)cc3c2N1CC3 CHEMBL1765212 IC50 4.4 nM
CC(C#N)c1cncc(-c2cnc3c(c2)CCCN3C(N)=O)c1 CHEMBL3956078 IC50 4.4 nM
N#Cc1ccc2c(c1)CCC(c1cccnc1)=C2 CHEMBL500663 IC50 4.5 nM
OC1CCc2c(-c3ccc(C(F)(F)F)cc3F)cncc21 CHEMBL3913469 EC50 4.5 nM
COc1cccc(-c2cncc(-c3cc4c5c(c3)CCN5C(=O)CC4)c2)c1 CHEMBL1765227 IC50 4.6 nM
NC(=O)N1CCCc2cc(-c3cncc(OCC4CCOCC4)c3)cnc21 CHEMBL3893385 IC50 4.6 nM
NC(=O)N1CCCc2cc(-c3cncc(-c4ccccc4CO)c3)cnc21 CHEMBL3971650 IC50 4.6 nM
OC1CCCc2c(-c3ccc(C(F)(F)F)cc3)cncc21 CHEMBL3911227 EC50 4.6 nM
N#Cc1ccc(-c2cncc(OCCF)c2)cc1Cl CHEMBL5397427 IC50 4.6 nM
CC(C#N)c1cncc(-c2ccc(C#N)c(F)c2)c1 CHEMBL5415158 IC50 4.6 nM
Fc1cncc(-c2nc3cc(F)c(F)cc3n2C2CC2)c1 CHEMBL3582472 IC50 4.7 nM
C[C@@](O)(c1cncc(-c2nc3ccc(F)cn3c2C2CC2)c1)C(F)(F)F CHEMBL3935155 IC50 4.7 nM
Cc1cc(C#N)ccc1-c1cnn2c1C[C@@H](Oc1ncc(F)cn1)C2 CHEMBL4129619 IC50 4.7 nM
COc1ccc2cc(-c3cncc(-c4ccccc4)c3)ccc2c1 CHEMBL500393 IC50 4.8 nM
CC1(O)CCc2c(-c3ccc(C(F)(F)F)cc3)cncc21 CHEMBL3956360 EC50 4.8 nM
CC(=O)N[C@@H]1CCCc2c(-c3ccc4c(c3)CCC(=O)N4C)cncc21 CHEMBL4107996 EC50 4.8 nM
COc1ccc2c(c1)CC/C2=C/c1cncs1 CHEMBL195354 IC50 5.0 nM
C(=C1c2ccccc2-c2ccccc21)c1ccncc1 CHEMBL383145 IC50 5.0 nM
CC1Cc2ccccc2C=C1c1cccnc1 CHEMBL206550 IC50 5.0 nM
COc1ccc(Cc2cc3cc(OC)ccc3cc2-c2cncc3ccccc23)cc1 CHEMBL494315 IC50 5.0 nM
COC(C)(C)c1cncc(-c2ccc3c(c2)CCc2nnc(C)n2-3)c1 CHEMBL2331704 IC50 5.0 nM
Cc1nnc2n1-c1ccc(-c3cncc4ccccc34)cc1CC2 CHEMBL2331706 IC50 5.0 nM
COc1cc(C#N)ccc1[C@H]1CCc2cncn21 CHEMBL3099694 IC50 5.0 nM
COc1cc(C#N)ccc1[C@@]1(C(=O)N(C)Cc2ccc(F)cc2)CCc2cncn21 CHEMBL3099690 IC50 5.0 nM
CCS(=O)(=O)N(Cc1cncc(-c2cccc(Cl)c2Cl)c1)C1CC1 CHEMBL3313981 IC50 5.0 nM
CCS(=O)(=O)NCc1cncc(-c2c(C)c3ccccc3n2C)c1 CHEMBL3313976 IC50 5.0 nM
COc1cccc(S(=O)(=O)N2CCCc3cc(Cc4ccncc4)ccc32)c1 CHEMBL3337694 IC50 5.0 nM
COC(=O)c1cncc(-c2cnc3c(c2)CCCN3C(N)=O)c1 CHEMBL3951475 IC50 5.0 nM
Cc1ccc(C2(O)CCCc3c(-c4ccc(C#N)cc4)cncc32)cc1C CHEMBL3927826 EC50 5.0 nM
Cc1c(COc2ncccc2F)cncc1-c1cc2c(cc1F)N(C)C(=O)CC2 CHEMBL3965248 EC50 5.0 nM
CS(=O)(=O)N1CCC(C(O)c2cncnc2Nc2cccc(F)c2)CC1 CHEMBL4072943 IC50 5.0 nM
CC(C)C(O)(c1cncnc1Nc1ccc(F)cc1)C1CCN(S(C)(=O)=O)CC1 CHEMBL4093575 IC50 5.0 nM
CC(C)c1ncncc1-c1nc2cc(F)c(F)cc2n1C1CC1 CHEMBL4460841 IC50 5.0 nM
CC(=O)N1CCC(c2cncc(N3C(=O)c4ccc(Cl)cc4C3(C)C)c2)CC1 CHEMBL4644311 IC50 5.0 nM
CC1(C)c2cc(Cl)ccc2C(=O)N1c1cncc(OC2CN(C(=O)c3ncccc3Cl)C2)c1 CHEMBL4632945 IC50 5.0 nM
CCOc1cncc(-c2ccc3cc(OC)ccc3c2)c1 CHEMBL445259 IC50 5.1 nM
N#CC1CCc2cc(-c3cccnc3)ccc2C1 CHEMBL459970 IC50 5.1 nM
Brc1ccc(Cn2cncc2-c2ccccc2)cc1 CHEMBL597173 IC50 5.1 nM
NC(=O)N1CCCc2cc(-c3cnccc3Cl)cnc21 CHEMBL3896825 IC50 5.1 nM
Cc1cccc(-c2cncn2Cc2ccc(C#N)cc2)c1 CHEMBL607862 IC50 5.2 nM
CC(C)CC1n2cncc2CN(Cc2ccc(Cl)cc2)S1(=O)=O CHEMBL1209553 IC50 5.2 nM
NC(=O)N1CCCc2cc(-c3cncc(-c4ccc(F)cc4)c3)cnc21 CHEMBL3891561 IC50 5.2 nM
CNC(=O)c1ccc(-c2cncc(-c3cnc4c(c3)CCCN4C(N)=O)c2)cc1 CHEMBL3961657 IC50 5.2 nM
NC(=O)N1CCCc2cc(-c3cncc(O)c3)cnc21 CHEMBL3968019 IC50 5.2 nM
NC(=O)N1CCCc2cc(-c3cncc(C4(O)CCC4)c3)cnc21 CHEMBL3949692 IC50 5.2 nM
OC1CCc2c(-c3ccc(C(F)(F)F)c(F)c3)cncc21 CHEMBL3900969 EC50 5.2 nM
NC(=O)N1CCCc2cc(-c3cncc(-c4ccccc4)c3)cnc21 CHEMBL3907242 IC50 5.3 nM
CN1C(=O)CCc2cc(-c3cncc4c3CCC[C@H]4NC(=O)c3ncccc3Cl)ccc21 CHEMBL4109855 EC50 5.3 nM
NC(=O)N1CCCc2cc(-c3cncc(COc4ccc(F)cc4)c3)cnc21 CHEMBL3930692 IC50 5.4 nM
NC(=O)N1CCCc2cc(-c3cncc(-c4ccc(N5CCOCC5)nc4)c3)cnc21 CHEMBL3897329 IC50 5.4 nM
N#Cc1ccc(-c2cnn3c2CCC3)c(Cl)c1 CHEMBL4128167 IC50 5.4 nM
N#Cc1ccc(Cn2cncc2-c2cccc(F)c2)cc1 CHEMBL598789 pIC50 5.495 nM
CN1C(=O)CCc2cc(-c3cncc4c3CCC[C@H]4N)ccc21 CHEMBL4110349 EC50 5.6 nM
Cn1c(-c2cncc(-c3cnc4c(c3)CCCN4C(N)=O)c2C#N)cc2ccccc21 CHEMBL3964259 IC50 5.7 nM
COc1cncc(-c2ccc(C#N)c(F)c2)n1 CHEMBL5438181 IC50 5.7 nM
Clc1ccc(Cn2cncc2-c2ccccc2)cc1 CHEMBL597101 pIC50 5.754 nM
CCC(c1cc2c3c(c1)CCN3C(=O)CC2)n1ccnc1 CHEMBL2163637 IC50 5.8 nM
C[C@](O)(c1cncc(-c2nc3ccc(C#N)cn3c2C2CC2)c1)C(F)(F)F CHEMBL3942187 IC50 5.8 nM
NC(=O)N1CCCc2cc(-c3cnccc3C(F)(F)F)cnc21 CHEMBL3926683 IC50 5.8 nM
NC(=O)N1CCCc2c1ncc(-c1cncc(CN3CCOCC3=O)c1)c2Cl CHEMBL3940098 IC50 5.8 nM
O=C1CCc2cc(-c3cncc(C(F)(F)F)c3)cc3c2N1CC3 CHEMBL1765213 IC50 5.9 nM
CN(C)C(=O)c1ccc(-c2cncc(-c3cnc4c(c3)CCCN4C(N)=O)c2)cc1 CHEMBL3912297 IC50 5.9 nM
CCc1cncc(-c2cnc3c(c2)CCCN3C(N)=O)c1 CHEMBL3938745 IC50 5.9 nM
Fc1ccc2c(c1)CC/C2=C\c1cncnc1 CHEMBL195248 IC50 6.0 nM
C(=C1c2ccccc2-c2ccccc21)c1cccnc1 CHEMBL194928 IC50 6.0 nM
COc1ccc2cc(-c3cccnc3)ccc2c1 CHEMBL362968 IC50 6.0 nM
NC(=O)N1CCCc2cc(-c3cncc(-c4cccc(CO)c4)c3)cnc21 CHEMBL3944672 IC50 6.0 nM
Cc1c(F)cncc1-c1cc(F)c2c(c1)CCc1nnc(C)n1-2 CHEMBL3415173 IC50 6.0 nM
Cc1cncc(Cc2cc(-c3ccccc3)nn2C)c1 CHEMBL4068439 IC50 6.0 nM
CCC(=O)N[C@@H]1CCCc2c1cncc2N1C(=O)c2ccc(Cl)cc2[C@@H]1C CHEMBL4647877 IC50 6.0 nM
NC(=O)N1CCCc2cc(-c3cncc(-c4ccc(C(=O)NCCO)cc4)c3)cnc21 CHEMBL3965459 IC50 6.1 nM
NC(=O)N1CCCc2cc(-c3cncc(COC4CCOCC4)c3)cnc21 CHEMBL3984014 IC50 6.1 nM
OCCCc1cncn1Cc1ccc(Br)cc1 CHEMBL598810 pIC50 6.166 nM
NC(=O)N1CCCc2cc(-c3cncc(Cl)c3)cnc21 CHEMBL3893531 IC50 6.3 nM
Cc1ccc(-c2cncc(-c3cnc4c(c3)CCCN4C(N)=O)c2)cn1 CHEMBL3921979 IC50 6.3 nM
CC1(C)CCN(C(=O)COCc2cncc(-c3cnc4c(c3)CCCN4C(N)=O)c2)C1 CHEMBL3903448 IC50 6.3 nM
N#Cc1ccc(-c2cncc(-c3ccc(F)nc3)c2)cc1Cl CHEMBL5398781 IC50 6.4 nM
C[C@](O)(c1cncc(-c2nc3ccc(F)cn3c2C2CC2)c1)C(F)(F)F CHEMBL3923127 IC50 6.6 nM
Fc1ccc2nc(-c3cncc(-c4ccccc4)c3)c(C3CC3)n2c1 CHEMBL3939565 IC50 6.6 nM
CCc1c(F)cncc1-c1nc2ccc(F)cn2c1C1CC1 CHEMBL3919759 IC50 6.6 nM
CC(O)c1cncc(-c2cnc3c(c2)CCCN3C(N)=O)c1 CHEMBL3928523 IC50 6.6 nM
NC(=O)N1CCCc2cc(-c3cncc(CN4CCCC4=O)c3)cnc21 CHEMBL3959564 IC50 6.7 nM
Cc1cc(-c2cnn3c2CCC3)ccc1C#N CHEMBL4127082 IC50 6.7 nM
N#Cc1ccc(-c2cncc(C(F)(F)F)c2)cc1F CHEMBL5426685 IC50 6.7 nM
COCc1ccncc1-c1cnc2c(c1)CCCN2C(N)=O CHEMBL3925276 IC50 6.8 nM
NC(=O)N1CCCc2cc(-c3cncc(COc4ccccc4)c3)cnc21 CHEMBL3958062 IC50 6.8 nM
CN1C(=O)CCc2cc(-c3cncc(CC(=O)Nc4cccc(Cl)n4)c3)ccc21 CHEMBL3967847 EC50 6.8 nM
COC(=O)Cc1cncc(-c2ccc3cc(OC)ccc3c2)c1 CHEMBL526339 IC50 6.9 nM
NC(=O)c1ccc(-c2cncc(-c3cnc4c(c3)CCCN4C(N)=O)c2)cc1 CHEMBL3895048 IC50 6.9 nM
Fc1ccc2c(c1)CC/C2=C\c1cccnc1 CHEMBL193997 IC50 7.0 nM
CC1=C(c2cccnc2)CCc2ccccc21 CHEMBL206283 IC50 7.0 nM
C1=C(c2cccnc2)CCc2ccccc21 CHEMBL205881 IC50 7.0 nM
COc1ccc2cc(-c3cccnc3)c(C)cc2c1 CHEMBL499871 IC50 7.0 nM
COC(=O)c1cncn1Cc1ccc(C#N)cc1 CHEMBL591698 IC50 7.0 nM
O=[N+]([O-])c1ccc(-c2ccncc2)c(OCCc2ccccc2)c1 CHEMBL3421769 IC50 7.0 nM
CCC(=O)NC1CCCc2c(-c3ccc(Cl)c(F)c3)cncc21 CHEMBL3623829 EC50 7.0 nM
CCC(=O)N[C@H]1CCc2c(-c3ccc(Cl)c(F)c3)cncc21 CHEMBL3956616 EC50 7.0 nM
O=S(=O)(c1cnccc1Nc1cccc(C(F)(F)F)c1)N1CCOCC1 CHEMBL4097020 IC50 7.0 nM
CC[C@@H]1c2cc(Cl)ccc2C(=O)N1c1cncc2c1CCC[C@H]2NC(C)=O CHEMBL4639314 IC50 7.0 nM
CC(=O)N1CC[C@H](Oc2cncc(N3C(=O)c4ccc(Cl)cc4C3(C)C)c2)C1 CHEMBL4638889 IC50 7.0 nM
Cc1nnc2n1-c1c(F)cc(-c3cncc(-c4ccccc4)c3)cc1CC2 CHEMBL3415171 IC50 7.1 nM
COCc1cncc(-c2cnc3c(c2)CCCN3C(N)=O)c1 CHEMBL3891562 IC50 7.1 nM
NC(=O)N1CCCc2cc(-c3cncc(COCC(=O)N4CCC5(CC4)CC5)c3)cnc21 CHEMBL3902834 IC50 7.2 nM
N#Cc1ccc(-c2cncc(Br)c2)cc1F CHEMBL5401923 IC50 7.2 nM
N#Cc1ccc(-c2cncc(-c3ccccc3)c2)cc1F CHEMBL5424651 IC50 7.2 nM
Fc1cncc(-c2nc3cc(F)c(Cl)cn3c2C2CC2)c1 CHEMBL3951973 IC50 7.3 nM
N#CCc1cncc(-c2cnc3c(c2)CCCN3C(N)=O)c1 CHEMBL3920812 IC50 7.3 nM
N#Cc1ccncc1-c1cnc2c(c1)CCCN2C(N)=O CHEMBL3980398 IC50 7.3 nM
N#Cc1c(-c2ccc(F)cc2)cncc1-c1cnc2c(c1)CCCN2C(N)=O CHEMBL3891874 IC50 7.3 nM
Cc1nnc2n1-c1c(F)cc(-c3cncc(F)c3C3CC3)cc1CC2 CHEMBL3945789 IC50 7.3 nM
Cc1c(-c2cncc(-c3cnc4c(c3)CCCN4C(N)=O)c2)cnn1C CHEMBL3908015 IC50 7.5 nM
CNS(=O)(=O)c1cccc(-c2cncc(-c3cnc4c(c3)CCCN4C(N)=O)c2)c1 CHEMBL3946323 IC50 7.5 nM
N#Cc1ccc(-c2cncc(C(F)F)c2)cc1F CHEMBL5431649 IC50 7.5 nM
CC(C)(O)c1cncc(-n2ncc3c(F)cccc32)c1 CHEMBL4081339 IC50 7.58 nM
COc1ccc(Cc2cc3cc(OC)ccc3cc2-c2cncc(OC)c2)cc1 CHEMBL493089 IC50 7.6 nM
COc1ccc(Cc2cc3ccccc3cc2-c2cncc(OC)c2)cc1 CHEMBL446775 IC50 7.7 nM
NC(=O)N1CCCc2cc(-c3cncc(-c4ccc(S(=O)(=O)NCCO)cc4)c3)cnc21 CHEMBL3980071 IC50 7.7 nM
Cc1cccc2c1cnn2-c1cncc(C(C)(C)O)c1 CHEMBL4061038 IC50 7.77 nM
COc1ccc(Cc2cc3ccccc3cc2-c2cccnc2)cc1 CHEMBL493082 IC50 7.8 nM
O=C1CCc2cc(-c3cccnc3)ccc2C1 CHEMBL462093 IC50 7.8 nM
C[C@@H](c1ccc(Cl)cc1)N1Cc2cncn2C(CC2(C)COC2)S1(=O)=O CHEMBL1209628 IC50 7.8 nM
CCc1c(-c2cncc(C)c2)nn2c1N(C)C(=O)CC2 CHEMBL3936160 IC50 7.8 nM
Cc1c(F)cncc1-c1nc2ccc(F)cn2c1C1CC1 CHEMBL3924257 IC50 7.9 nM
C(=C1\CCc2ccccc21)\c1ccncc1 CHEMBL175962 IC50 8.0 nM
Cc1ccc2c(c1)/C(=C\c1ccncc1)CC2 CHEMBL192077 IC50 8.0 nM
c1ccc(C(Cn2ccnc2)(c2ccccc2)c2ccccc2)cc1 CHEMBL1651508 IC50 8.0 nM
COc1cccc(S(=O)(=O)N2CCCc3cc(Cc4cccnc4)ccc32)c1 CHEMBL3337695 IC50 8.0 nM
NC(=O)N1CCCc2cc(-c3cncc(-c4ccncc4)c3)cnc21 CHEMBL3968477 IC50 8.0 nM
N#Cc1ccc(-c2cncc3c2CCCC3O)cc1 CHEMBL3915255 EC50 8.0 nM
CS(=O)(=O)N1CCC(C(O)c2cncnc2Nc2cccc3ccccc23)CC1 CHEMBL4061565 IC50 8.0 nM
Cc1ccc(Nc2ncncc2C(O)C2CCN(S(C)(=O)=O)CC2)cc1 CHEMBL4092081 IC50 8.0 nM
Cc1cncc(Cc2cc(-c3ccccc3)ns2)c1 CHEMBL4093884 IC50 8.0 nM
CCc1ncncc1-c1nc2cc(F)c(F)cc2n1C1CC1 CHEMBL4470436 IC50 8.0 nM
C[C@@H](NS(C)(=O)=O)c1cncc(N2C(=O)c3ccc(Cl)cc3C2(C)C)c1 CHEMBL4632486 IC50 8.0 nM
Fc1cc2nc(-c3cnccc3C(F)(F)F)n(C3CC3)c2cc1F CHEMBL3582480 IC50 8.1 nM
CC(=O)Nc1cccc(-c2cncc(-c3cnc4c(c3)CCCN4C(N)=O)c2)c1 CHEMBL3931970 IC50 8.4 nM
O=c1c2ccccc2oc2c(Br)ccc(Cn3ccnc3)c12 CHEMBL78322 IC50 8.5 nM
CC(C)C(O)c1cncc(-c2cnc3c(c2)CCCN3C(N)=O)c1 CHEMBL3912933 IC50 8.6 nM
NC(=O)N1CCCc2cc(-c3cncc(COCC(=O)N4CCC(F)(F)CC4)c3)cnc21 CHEMBL3942356 IC50 8.6 nM
NC(=O)N1CCCc2c1ncc(-c1cncc(C3(O)CCOCC3)c1)c2Cl CHEMBL3957069 IC50 8.7 nM
CCC(=O)NC1CCc2c(-c3cc(Cl)c4c(c3)CCC(=O)N4C)cncc21 CHEMBL3923987 EC50 8.8 nM
Clc1cccc2c1CC/C2=C\c1cccnc1 CHEMBL176287 IC50 9.0 nM
C(=C(c1ccccc1)c1ccccc1)c1cccnc1 CHEMBL370317 IC50 9.0 nM
CCC(=O)N[C@@H]1CCCc2c(-c3ccc(C#N)cc3)cncc21 CHEMBL3623830 IC50 9.0 nM
CCN(CC)C(=O)COCc1cncc(-c2cnc3c(c2)CCCN3C(N)=O)c1 CHEMBL3927907 IC50 9.0 nM
N#Cc1ccc2nc(-c3cncnc3C(F)F)n(C3CC3)c2c1 CHEMBL4548610 IC50 9.0 nM
Cc1cccnc1C(=O)NCc1cncc(N2C(=O)c3ccc(Cl)cc3C2(C)C)c1 CHEMBL4643528 IC50 9.0 nM
CC(=O)N1CCN(c2cncc(N3C(=O)c4ccc(Cl)cc4C3(C)C)c2)CC1 CHEMBL4634550 IC50 9.0 nM
COc1ccc2cc(-c3cncc(CO)c3)ccc2c1 CHEMBL448064 IC50 9.1 nM
NC(=O)N1CCOc2cc(-c3cccnc3)cnc21 CHEMBL3905962 IC50 9.1 nM
CCS(=O)(=O)N(C)[C@H](C)c1cncc(-c2cnc3c(c2)CCCN3C(N)=O)c1 CHEMBL4110564 IC50 9.1 nM
N#Cc1ccncc1-c1cnc2c(c1)CCN2C(N)=O CHEMBL3915466 IC50 9.1 nM
NC(=O)N1CCCc2cc(-c3cncc(CO)c3)cnc21 CHEMBL3901051 IC50 9.2 nM
N#Cc1ccc(-c2cnn3c2CCC3)c(F)c1 CHEMBL4129549 IC50 9.2 nM
CC(C)CC1n2cncc2CN([C@@H](C)c2ccc(Cl)cc2)S1(=O)=O CHEMBL1209625 IC50 9.4 nM
Cc1nnc2n1-c1c(F)cc(-c3cncc(F)c3C(C)C)cc1CC2 CHEMBL3975161 IC50 9.5 nM
C(=C1/CCCc2ccccc21)\c1c[nH]cn1 CHEMBL367719 IC50 9.6 nM
CCS(=O)(=O)N(C)[C@@H](C)c1cncc(-c2cnc3c(c2)CCCN3C(N)=O)c1 CHEMBL3912552 IC50 9.6 nM
NC(=O)N1CCCc2cc(-c3cncc(OCc4cccnn4)c3)cnc21 CHEMBL3938157 IC50 9.6 nM
N#Cc1ccc(-c2cncc(Cl)c2)cc1F CHEMBL5405763 IC50 9.6 nM
CC(=O)c1c(F)cncc1-c1cnc2c(c1)CCCN2C(N)=O CHEMBL3931071 IC50 9.7 nM
Cc1cncc(-c2nn3c(c2C)N(C)C(=O)CC3)c1 CHEMBL3913405 IC50 9.8 nM