O=C(OCc1cccnc1)C12CC3CC(CC(C3)C1)C2 CHEMBL113647 pIC50 2.037e-11 nM
N=C(N)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4130227 IC50 0.017 nM
CCS(=O)(=O)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3913908 IC50 0.73 nM
CC(C)S(=O)(=O)N1CCN(c2ccc(/C=C/c3cc(F)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4127656 IC50 1.0 nM
O=S(=O)(C1CC1)N1CCN(c2ccc(/C=C/c3cc(F)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4126996 IC50 1.0 nM
Cc1ccncc1-c1cccc2c(-c3ccccc3)noc12 CHEMBL3696099 IC50 1.0 nM
C[C@]12CC[C@H](O)CC1=CCC1C2CC[C@]2(C)C(n3ccnc3)=CCC12 CHEMBL74661 Ki 1.2 nM
C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(n3ccnc3)=CC[C@@H]12 CHEMBL2392006 Ki 1.2 nM
C[C@]12CC[C@H](O)CC1=CCC1C2CC[C@]2(C)C(n3ccnn3)=CCC12 CHEMBL78108 Ki 1.4 nM
C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(n3ccnn3)=CC[C@@H]12 CHEMBL3415119 Ki 1.4 nM
Cc1cc(NS(C)(=O)=O)ccc1-c1cnccc1OCC(F)(F)F CHEMBL3666697 IC50 1.4 nM
C[C@]12CCC3c4ccc(O)cc4CCC3C1CC=C2c1cccnc1 CHEMBL310662 IC50 1.8 nM
C[C@H](OC(=O)C12CC3CC(CC(C3)C1)C2)c1ccncc1 CHEMBL110524 IC50 1.8 nM
C[C@]12CCC(=O)C=C1CCC1C2CC[C@]2(C)C(n3ccnc3)=CCC12 CHEMBL310336 Ki 1.9 nM
C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@]2(C)C(n3ccnc3)=CC[C@@H]12 CHEMBL3415124 Ki 1.9 nM
O=C1N(c2cc(Cl)nc(Cl)c2)CCN1c1cnccc1C1CC1 CHEMBL3677969 IC50 1.9 nM
Cc1ccncc1-c1cccc2c1cnn2-c1ccccn1 CHEMBL3782020 IC50 2.0 nM
O=S(=O)(N1CCN(c2ccc(/C=C/c3cc(F)cc(-c4ccncc4)c3)cc2)CC1)C(F)(F)F CHEMBL4128368 IC50 2.0 nM
CCS(=O)(=O)N1CCN(c2ccc(CCc3cc(F)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4285546 IC50 2.0 nM
C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(c3cccnc3)=CC[C@@H]12 CHEMBL254328 IC50 2.0 nM
Cc1ccncc1-c1cccc2c(-c3ccccc3)cnn12 CHEMBL5284599 IC50 2.0 nM
C[C@]12CCC(=O)C=C1CCC1C2CC[C@]2(C)C(c3cccnc3)=CCC12 CHEMBL432751 IC50 2.1 nM
COc1cc(NS(C)(=O)=O)ccc1-c1cnccc1C1CC1 CHEMBL3666702 IC50 2.1 nM
C[C@]12CCC3C(CC[C@H]4C[C@H](O)CC[C@]34C)C1CC=C2c1cccnc1 CHEMBL79829 IC50 2.5 nM
COc1cc(NS(C)(=O)=O)ccc1-c1cnccc1C CHEMBL3666698 IC50 2.5 nM
CC(C)(OC(=O)C12CC3CC(CC(C3)C1)C2)c1ccncc1 CHEMBL112908 IC50 2.7 nM
Cc1coc2ccc(N3CCN(c4cnccc4C4CC4)C3=O)cc12 CHEMBL3677940 IC50 2.7 nM
COc1ccc(S(=O)(=O)Nc2ccc(-c3cncc4ccccc34)c(OC)c2)cc1 CHEMBL3662060 IC50 2.7 nM
C[C@]12CCC(=O)C=C1CCC1C2C(=O)C[C@]2(C)C(c3cccnc3)=CCC12 CHEMBL311444 IC50 2.9 nM
COc1cc(NS(=O)(=O)c2ccccc2)ccc1-c1cncc2ccccc12 CHEMBL3662058 IC50 2.9 nM
C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)C1=CC[C@@H]2[C@H]1CN1 CHEMBL2111951 Ki 3.0 nM
C[C@]12CCC3C(CC[C@H]4CC(=O)CC[C@]34C)C1CC=C2c1cccnc1 CHEMBL84230 IC50 3.0 nM
Cc1ccncc1-c1cccc2c1cnn2-c1cccnn1 CHEMBL3780658 IC50 3.0 nM
O=S(=O)(C1CC1)N1CCN(c2ccc(CCc3cc(F)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4289969 IC50 3.0 nM
Cc1ccncc1-c1cccc2c(-c3ccccc3)csc12 CHEMBL5286021 IC50 3.0 nM
COc1cccc(-n2ncc3c(-c4cnccc4C)ccnc32)c1 CHEMBL5290743 IC50 3.0 nM
CS(=O)(=O)Nc1ccc(-c2cncc3ccccc23)c(OC(F)(F)F)c1 CHEMBL3666703 IC50 3.2 nM
Cc1ccncc1-c1cccc2c(-c3ccc(F)cc3)noc12 CHEMBL3696101 IC50 3.2 nM
COc1cc(NS(=O)(=O)Cc2ccc(Cl)cc2)ccc1-c1cncnc1C CHEMBL3666692 IC50 3.4 nM
CCOC(=O)CNC(=O)NC1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4284756 IC50 3.5 nM
O=S(=O)(C1CC1)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3922888 IC50 3.7 nM
Cc1ccncc1-c1ccnc2c(-c3ccc(F)cc3)noc12 CHEMBL3696108 IC50 3.9 nM
CC(c1ccc2c(c1)Cc1ccccc1-2)n1ccnc1 CHEMBL501198 IC50 4.0 nM
Cc1ccncc1-c1cccc2c1cnn2-c1nccs1 CHEMBL3780266 IC50 4.0 nM
Cc1ccncc1-c1cccc2c1cnn2-c1ccccc1 CHEMBL3780743 IC50 4.0 nM
Fc1ccc(-c2csc3c(-c4cncnc4C4CC4)ccnc23)cc1 CHEMBL3696111 IC50 4.0 nM
Nc1ncncc1-c1ccnc2c(-c3ccc(F)cc3Cl)csc12 CHEMBL3696112 IC50 4.0 nM
CC(C)S(=O)(=O)N1CCN(c2ccc(CCc3cc(F)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4289268 IC50 4.0 nM
CCOC(=O)CNC(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4291002 IC50 4.0 nM
Cc1ccncc1-c1ccnc2c1cnn2-c1ccc(F)cc1Cl CHEMBL5284859 IC50 4.0 nM
Fc1ccc(-n2ncc3c(-c4cncnc4N4CC(F)(F)C4)ccnc32)cc1 CHEMBL5265986 IC50 4.0 nM
Clc1ccccc1C(c1cc2cc(Br)ccc2o1)n1ccnc1 CHEMBL5436657 IC50 4.0 nM
CC(=O)N1CCN(c2ccc(/C=C/c3cc(F)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4129721 IC50 4.6 nM
O=C1N(c2cc(C3CC3)nc(C(F)(F)F)c2)CCN1c1cnccc1C1CC1 CHEMBL3677971 IC50 4.75 nM
C[C@]12CC[C@H](O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)C(c3cccnc3)CC[C@@H]12 CHEMBL3137967 IC50 5.0 nM
C[C@@H]1C(OC(=O)Cc2ccncc2)CC2CC1C2(C)C CHEMBL132072 IC50 5.0 nM
O=C1N(c2cc(Cl)nc(C(F)(F)F)c2)CCN1c1cnccc1C1CC1 CHEMBL3677960 IC50 5.0 nM
Cc1ccncc1-c1cccc2c1cnn2-c1ccc(F)cc1 CHEMBL3781112 IC50 5.0 nM
Cc1ccncc1-c1cccc2c1cnn2-c1cnccn1 CHEMBL3780226 IC50 5.0 nM
Cc1ccncc1-c1cccc2c1cnn2-c1cscn1 CHEMBL3780048 IC50 5.0 nM
O=S(=O)(C(F)F)N1CCN(c2ccc(/C=C/c3cc(F)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4127131 IC50 5.0 nM
CC(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4127399 IC50 5.0 nM
CS(=O)(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4126014 IC50 5.0 nM
CC(C)S(=O)(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4127256 IC50 5.0 nM
O=S(=O)(C1CC1)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4128640 IC50 5.0 nM
O=S(=O)(C(F)F)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4129859 IC50 5.0 nM
CS(=O)(=O)N1CCN(c2ccc(/C=C/c3cc(F)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4126429 IC50 5.0 nM
CCS(=O)(=O)N1CCN(c2ccc(/C=C/c3cc(F)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4126284 IC50 5.0 nM
O=S(=O)(C(F)F)N1CCN(c2ccc(/C=C/c3cc(F)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4126956 IC50 5.0 nM
Clc1cc(/C=C/c2ccc(N3CCN(C4=NCCO4)CC3)cc2)cc(-c2ccncc2)c1 CHEMBL4126816 IC50 5.0 nM
Fc1cc(/C=C/c2ccc(N3CCN(C4=NCCO4)CC3)cc2)cc(-c2ccncc2)c1 CHEMBL4129428 IC50 5.0 nM
Fc1cc(/C=C/c2ccc(N3CCN(CC4CC4)CC3)cc2)cc(-c2ccncc2)c1 CHEMBL4286910 IC50 5.0 nM
Cc1ccncc1-c1ccnn2c(-c3ccccc3)ccc12 CHEMBL5280658 IC50 5.0 nM
Cc1ccncc1-c1ccnc2c(-c3ccccc3)noc12 CHEMBL5284207 IC50 5.0 nM
Cc1ccncc1-c1ccnc2c1cnn2-c1ncccc1Cl CHEMBL5269382 IC50 5.0 nM
Nc1ccncc1-c1ccnc2c1cnn2-c1ccc(F)cc1 CHEMBL5290106 IC50 5.0 nM
Nc1ncncc1-c1ccnc2c1cnn2-c1c(F)cc(F)cc1F CHEMBL5286147 IC50 5.0 nM
O=C1N(c2cc(Cl)nc(C3CC3)c2)CCN1c1cnccc1C1CC1 CHEMBL3677970 IC50 5.2 nM
COc1cc(NS(=O)(=O)c2ccccc2)ccc1-c1cncnc1C CHEMBL3662070 IC50 5.4 nM
CNC(=O)c1ccc2cc([C@](O)(c3c[nH]cn3)C(C)C)ccc2c1 CHEMBL1921975 IC50 5.5 nM
C[C@]12CCC=CC1=CCC1C2CC[C@]2(C)C(c3cccnc3)=CCC12 CHEMBL310315 IC50 5.6 nM
Cc1ccncc1-c1cccc2c1ncn2-c1ccccn1 CHEMBL2147034 IC50 5.8 nM
CC12CCC(O)CC1=CCC1C2CCC2(C)C(CC3CN3)CCC12 CHEMBL341591 Ki 6.0 nM
CC(C(=O)OC1CC2CC([C@@H]1C)C2(C)C)c1ccncc1 CHEMBL133724 IC50 6.0 nM
O=C1N(c2cccc(C(F)(F)F)c2)CCN1c1cnccc1C1CC1 CHEMBL3677927 IC50 6.0 nM
O=C1N(c2cnccc2C2CC2)[C@@H]2C[C@@H]2N1c1ccnc(Cl)c1 CHEMBL3677951 IC50 6.0 nM
O=C1N(c2cc(C(F)(F)F)nc(C(F)(F)F)c2)CCN1c1cnccc1C1CC1 CHEMBL3677972 IC50 6.0 nM
COc1cc(NS(=O)(=O)c2ccccn2)ccc1-c1cncc2ccccc12 CHEMBL3662065 IC50 6.0 nM
O=C1N(c2cc(F)c3ccsc3c2)CCN1c1cnccc1C1CC1 CHEMBL3677947 IC50 6.0 nM
N#CCS(=O)(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4128495 IC50 6.0 nM
Cc1ccncc1-c1ccnc2c1cnn2-c1ccc(F)cc1 CHEMBL5286511 IC50 6.0 nM
C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@]2(C)C(c3cccnc3)=CC[C@@H]12 CHEMBL132778 IC50 6.13 nM
COc1cc(NS(=O)(=O)C2CC2)ccc1-c1cncc2ccccc12 CHEMBL3662064 IC50 6.2 nM
O=S(=O)(c1c[nH]cn1)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4127240 IC50 6.2 nM
COc1cc(NS(C)(=O)=O)ccc1-c1cncc2ccccc12 CHEMBL3662057 IC50 6.6 nM
Cc1csc2ccc(N3CCN(c4cnccc4C4CC4)C3=O)cc12 CHEMBL3677936 IC50 6.7 nM
O=C1N(c2cnccc2C2CC2)[C@@H]2C[C@@H]2N1c1ccnc(C(F)(F)F)c1 CHEMBL3677955 IC50 6.9 nM
O=C1N(c2cc3cc(F)ccc3s2)CCN1c1cnccc1C1CC1 CHEMBL3677943 IC50 7.0 nM
O=C1N(c2ccc3ccsc3c2)CCN1c1cnccc1C1CC1 CHEMBL3677937 IC50 7.0 nM
CS(=O)(=O)CS(=O)(=O)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3980889 IC50 7.0 nM
CCOC(=O)CNC(=O)N1CCN(c2ccc(CCc3cc(F)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4288241 IC50 7.0 nM
O=S(=O)(c1cccnc1)N1CCN(c2ccc(/C=C/c3cc(F)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4288168 IC50 7.0 nM
Cc1ccncc1-c1ccnc2c1cnn2-c1ccccc1 CHEMBL5266728 IC50 7.0 nM
C[C@]12CC[C@H](O)C[C@@H]1[C@@H](O)C[C@@H]1[C@@H]2CC[C@]2(C)C(c3cccnc3)=CC[C@@H]12 CHEMBL4213452 IC50 7.2 nM
Cc1ccncc1-c1ccc(NS(=O)(=O)C2CC2)cc1OCC(F)(F)F CHEMBL3666695 IC50 7.7 nM
C[C@]12CC[C@H]3[C@@H](C[C@@H]4C[C@@]45C[C@@H](O)CC[C@]35C)[C@@H]1CC=C2c1cccnc1 CHEMBL4210737 IC50 7.83 nM
C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CC[C@@H]2[C@H]1CN1 CHEMBL2111947 Ki 8.0 nM
C[C@]12CCC(=O)C=C1CCC1C2CC[C@]2(C)C(n3ccnn3)=CCC12 CHEMBL78003 Ki 8.0 nM
C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@]2(C)C(n3ccnn3)=CC[C@@H]12 CHEMBL3415125 Ki 8.0 nM
O=C1N(c2ccnc(Cl)c2)CCN1c1cnccc1C1CC1 CHEMBL3639767 IC50 8.0 nM
Cc1ccncc1-c1cccc2c1ncn2-c1nccs1 CHEMBL3781487 IC50 8.0 nM
Cc1ccncc1-c1cccc2c1ncn2-c1cscn1 CHEMBL3781910 IC50 8.0 nM
O=S(=O)(C(F)F)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3968178 IC50 8.0 nM
Cc1ncncc1-c1ccnc2c(-c3ccc(F)cc3)csc12 CHEMBL3696110 IC50 8.0 nM
CCOC(=O)CNC(=O)N1CCN(c2ccc(/C=C/c3cc(F)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4283402 IC50 8.0 nM
CC(=O)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)OC3)cc2)CC1 CHEMBL4289930 IC50 8.0 nM
Cc1ccncc1-c1cccc2c1OCCN2c1ccccc1 CHEMBL5290740 IC50 8.0 nM
Fc1ccc(-n2ncc3c(-c4cncnc4NCC(F)(F)F)ccnc32)cc1 CHEMBL5269068 IC50 8.0 nM
Nc1ncncc1-c1ccnc2c1cnn2-c1ccc(F)cc1 CHEMBL5290029 IC50 8.0 nM
CCS(=O)(=O)Nc1ccc(-c2cncc3ccccc23)c(OC)c1 CHEMBL3662062 IC50 8.1 nM
CCC(C(=O)OC1CC2CC([C@@H]1C)C2(C)C)c1ccncc1 CHEMBL336102 IC50 9.0 nM
O=C1N(c2ccnc(C(F)(F)F)c2)CCN1c1cnccc1C1CC1 CHEMBL3677924 IC50 9.0 nM
N#CCS(=O)(=O)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3952032 IC50 9.0 nM
O=S(=O)(c1cccs1)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3960724 IC50 9.0 nM
Cc1ccncc1-c1ccnn2c(-c3cccs3)cnc12 CHEMBL3965336 IC50 9.0 nM
O=[N+]([O-])c1cccc(S(=O)(=O)N2CCN(c3ccc(/C=C/c4cc(Cl)cc(Cn5ccnc5)c4)cc3)CC2)c1 CHEMBL4287787 IC50 9.0 nM
CCS(=O)(=O)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)OC3)cc2)CC1 CHEMBL4291856 IC50 9.0 nM
COc1ccccc1-n1ncc2c(-c3cnccc3C)ccnc21 CHEMBL5277196 IC50 9.0 nM
Cc1ccncc1-c1ccnc2c1cnn2-c1ccc(F)cc1F CHEMBL5274940 IC50 9.0 nM
COc1cc(NS(=O)(=O)Cc2ccccc2)ccc1-c1cncnc1C CHEMBL3666688 IC50 9.6 nM
C[C@@H]1C(OC(=O)C(C)(C)c2ccncc2)CC2CC1C2(C)C CHEMBL135070 IC50 10.0 nM
O=C1N(c2cc(Cl)nc(C(F)(F)F)n2)CCN1c1cnccc1C1CC1 CHEMBL3677968 IC50 10.0 nM
C=C1C[C@H]2C3=CC=C(c4cccnc4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12 CHEMBL3944649 IC50 10.0 nM
C=C1C[C@@H]2[C@H](CC[C@]3(C)C(c4cccnc4)=CC[C@@H]23)[C@@]2(C)CCC(=O)C=C12 CHEMBL3958540 IC50 10.0 nM
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)C1=CC=C2c1cncnc1 CHEMBL3964049 IC50 10.0 nM
C[C@]12CC[C@H]3[C@@H](CC4(CC4)C4=CC(=O)CC[C@@]43C)C1=CC=C2c1cncc(F)c1 CHEMBL3982478 IC50 10.0 nM
C=C1C[C@H]2C3=CC=C(c4cncc(F)c4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12 CHEMBL3985019 IC50 10.0 nM
CC1C[C@@H]2[C@H](CC[C@]3(C)C(c4cccnc4)=CC[C@@H]23)[C@@]2(C)CCC(=O)C=C12 CHEMBL3969480 IC50 10.0 nM
CC1C[C@H]2C3=CC=C(c4cccnc4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCN(C)C(=O)C=C12 CHEMBL3952895 IC50 10.0 nM
CCC1C[C@H]2C3=CC=C(c4cccnc4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12 CHEMBL3969233 IC50 10.0 nM
CCC(=O)N1CCC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@]2(C)C(n4ccnc4)=CC[C@@H]32)C1 CHEMBL3938811 IC50 10.0 nM
CN1CC[C@@]2(C)C(=CC1=O)C1CC1[C@H]1C3=CC=C(c4cccnc4)[C@@]3(C)CC[C@@H]12 CHEMBL3914206 IC50 10.0 nM
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)C1=CC=C2c1cncc(F)c1 CHEMBL3959459 IC50 10.0 nM
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)C1=CC=C2c1cccnc1 CHEMBL3957632 IC50 10.0 nM
CC1C[C@H]2C3=CC=C(c4cncc(F)c4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCNC(=O)C=C12 CHEMBL3919907 IC50 10.0 nM
CCC1C[C@@H]2[C@H](CC[C@]3(C)C(c4cccnc4)=CC[C@@H]23)[C@@]2(C)CCC(=O)C=C12 CHEMBL3938702 IC50 10.0 nM
CC1C[C@@H]2[C@H](CC[C@]3(C)C(c4cncc(F)c4)=CC[C@@H]23)[C@@]2(C)C=CC(=O)C=C12 CHEMBL3929550 IC50 10.0 nM
C[C@]12CC[C@H]3[C@@H](C=CC4=CC(=O)CC[C@@]43C)C1=CC=C2c1cccnc1 CHEMBL3891132 IC50 10.0 nM
Cc1ccncc1-c1ccnc2c(-c3ccccc3)csc12 CHEMBL5285321 IC50 10.0 nM
Cc1ccncc1-c1cccc2c1ncn2-c1cccc(F)n1 CHEMBL2147037 IC50 11.0 nM
COc1ccc2ccc(-c3cncc(O)c3)c(Cl)c2c1 CHEMBL2420683 IC50 11.0 nM
O=C1N(c2ccc3scc(C(F)(F)F)c3c2)CCN1c1cnccc1C1CC1 CHEMBL3677934 IC50 11.0 nM
O=S(=O)(C1CCOCC1)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3931836 IC50 11.0 nM
COc1cc(NS(=O)(=O)c2cccc3ccccc23)ccc1-c1cncc2ccccc12 CHEMBL3662059 IC50 11.0 nM
Fc1cc(/C=C/c2ccc(-c3ccncc3)cc2)cc(-c2ccncc2)c1 CHEMBL4283570 IC50 11.0 nM
O=S(=O)(C1CC1)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)OC3)cc2)CC1 CHEMBL4283588 IC50 11.0 nM
CC(C)S(=O)(=O)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)OC3)cc2)CC1 CHEMBL4287608 IC50 11.0 nM
COc1ccncc1-c1ccnc2c1cnn2-c1ccc(F)cc1 CHEMBL5286288 IC50 11.0 nM
Nc1ncncc1-c1ccnc2c1cnn2-c1ccc(F)cc1F CHEMBL5282485 IC50 11.0 nM
Nc1ncncc1-c1ccnc2c1cnn2-c1ncccc1C(F)(F)F CHEMBL5290887 IC50 11.0 nM
COc1ccc(-c2ccc([C@](O)(c3c[nH]cn3)C(C)C)cc2)cc1OC CHEMBL5409884 IC50 11.0 nM
Cc1ccncc1-c1cccc2c1ncn2CC(F)(F)F CHEMBL2147041 IC50 12.0 nM
O=C1N(c2ccnc(C3CC3)c2)CCN1c1cnccc1C1CC1 CHEMBL3677962 IC50 12.0 nM
COc1cc(N2C(=O)N(c3cnccc3C3CC3)[C@@H]3C[C@@H]32)ccn1 CHEMBL3677953 IC50 12.0 nM
CC(C)S(=O)(=O)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3894912 IC50 12.0 nM
CS(=O)(=O)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccccc4Cl)OC3)cc2)CC1 CHEMBL4285420 IC50 12.0 nM
C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(n3cnc4ccccc43)=CC[C@@H]12 CHEMBL2105738 IC50 12.16 nM
C[C@]12CC[C@H](O)C[C@@H]1C(=O)C[C@@H]1[C@@H]2CC[C@]2(C)C(c3cccnc3)=CC[C@@H]12 CHEMBL4209916 IC50 12.4 nM
CC(C)(C(=O)OC1(C)C2CC3CC(C2)CC1C3)c1cccnc1 CHEMBL3084923 IC50 13.0 nM
CC(C)(C(=O)OC12CC3CC(CC(C3)C1)C2)c1cccnc1 CHEMBL134169 IC50 13.0 nM
CNC(=O)c1ccc2cc(C3CCn4cncc43)ccc2c1 CHEMBL1921979 IC50 13.0 nM
O=C1N(c2ccnc(Cl)c2)CCN1c1cnccc1C1CCCC1 CHEMBL3677957 IC50 13.0 nM
O=C1N(c2cc3ccccc3s2)CCN1c1cnccc1C1CC1 CHEMBL3677928 IC50 13.0 nM
O=C1N(c2ccc3sccc3c2)CCN1c1cnccc1C1CC1 CHEMBL3677926 IC50 13.0 nM
O=S(=O)(c1cccnc1)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)OC3)cc2)CC1 CHEMBL4283318 IC50 13.0 nM
CC(C(=O)OC1CC2CC([C@@H]1C)C2(C)C)c1cccnc1 CHEMBL132066 IC50 14.0 nM
COc1c(F)cccc1-n1ncc2c(-c3cnccc3C)ccnc21 CHEMBL5275088 IC50 14.0 nM
Nc1ncncc1-c1ccnc2c1cnn2-c1ccc(F)cc1C(F)(F)F CHEMBL5267216 IC50 14.0 nM
C[C@@H]1C(OC(=O)C(C)(C)c2cccnc2)CC2CC1C2(C)C CHEMBL337251 IC50 15.0 nM
CC(C)C(O)(c1ccc2c3c(ccc2c1)C(=O)NC3)c1c[nH]cn1 CHEMBL1682900 IC50 15.0 nM
CS(=O)(=O)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3983734 IC50 15.0 nM
Cn1ccnc1S(=O)(=O)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3891718 IC50 15.0 nM
Cc1ccncc1C1=CC=C2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL3899979 IC50 15.0 nM
C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)C1=CC=C2c1cncc(C(F)F)c1 CHEMBL3934768 IC50 15.0 nM
CN(C)CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@H]3C4=CC=C(c5cccnc5)[C@@]4(C)CC[C@@H]32)C1 CHEMBL3904457 IC50 15.0 nM
C[C@]12CC[C@H](O)CC1=C(C#N)C[C@@H]1[C@@H]2CC[C@]2(C)C(c3cccnc3)=CC[C@@H]12 CHEMBL4209941 IC50 15.5 nM
C/C(=N/O)C1=CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C CHEMBL138272 IC50 16.0 nM
CNC(=O)c1ccc2cc(C(O)(c3c[nH]cn3)C(C)C)ccc2c1 CHEMBL1682893 IC50 16.0 nM
Oc1cncc(-c2ccc3ccc(O)cc3c2Cl)c1 CHEMBL2420684 IC50 16.0 nM
CC(=O)c1ccccc1-c1cnc2c(-c3cnccc3C)ccnn12 CHEMBL3902061 IC50 16.0 nM
C[C@]12CC[C@H](O)C[C@@H]1/C(=N\O)C[C@@H]1[C@@H]2CC[C@]2(C)C(c3cccnc3)=CC[C@@H]12 CHEMBL4214976 IC50 16.5 nM
O=S(=O)(N1CCN(c2ccc(CCc3cc(F)cc(-c4ccncc4)c3)cc2)CC1)C(F)(F)F CHEMBL4280378 IC50 16.5 nM
CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@@H]2CC[C@]2(C)C(c4cccnc4)=CC[C@@H]32)C1 CHEMBL271227 IC50 17.0 nM
O=C1N(c2ccc3c(c2)CCC3)CCN1c1cnccc1C1CC1 CHEMBL3677942 IC50 17.0 nM
O=S(=O)(c1cccnc1)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4128621 IC50 17.0 nM
Clc1cc(/C=C/c2ccc(N3CCN(CC4CC4)CC3)cc2)cc(Cn2ccnc2)c1 CHEMBL4279416 IC50 17.0 nM
O=C(c1cccc([N+](=O)[O-])c1)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4293550 IC50 17.0 nM
O=S(=O)(c1cccc(OC(F)(F)F)c1)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4288256 IC50 17.0 nM
O=C(OCc1ccncc1)C12CC3CC(CC(C3)C1)C2 CHEMBL113242 IC50 18.0 nM
CC(C)C(O)(c1cccc(-c2ccccc2)c1)c1c[nH]cn1 CHEMBL1766169 IC50 18.0 nM
N=C(N)N1CCN(c2ccc(/C=C/c3cc(F)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4128197 IC50 18.0 nM
CC(C)C(O)(c1ccc2cc3c(cc2c1)CN(C)C3=O)c1c[nH]cn1 CHEMBL1682903 IC50 19.0 nM
CC(C)[C@](O)(c1ccc2c3c(ccc2c1)C(=O)N(C)C3)c1c[nH]cn1 CHEMBL1682904 IC50 19.0 nM
CC(C)C(O)(c1cccc(-c2ccc(F)cc2)c1)c1c[nH]cn1 CHEMBL1766170 IC50 19.0 nM
CNC(=O)c1ccc2cc([C@@]3(O)CCn4cncc43)ccc2c1 CHEMBL1921976 IC50 19.0 nM
Cc1c(F)sc2ccc(N3CCN(c4cnccc4C4CC4)C3=O)cc12 CHEMBL3677945 IC50 19.0 nM
COCCS(=O)(=O)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3964421 IC50 19.0 nM
COCCOC(=O)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccccc4Cl)OC3)cc2)CC1 CHEMBL4278076 IC50 20.0 nM
Cc1ccncc1CN1CCc2c(sc3ccc(F)cc23)C1 CHEMBL4059780 IC50 20.1 nM
C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(c3ncc[nH]3)=CC[C@@H]12 CHEMBL2112522 IC50 21.0 nM
CNC(=O)Nc1cccc(-c2ccc(C(O)(c3c[nH]cn3)C(C)C)cc2)c1 CHEMBL1766180 IC50 21.0 nM
C[C@]12CC[C@H](O)CC1=CC[C@@H]1C2CC[C@]2(C)C(c3cccnc3)=CCC12 CHEMBL3780847 IC50 21.0 nM
O=S(=O)(C1CC1)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4127385 IC50 21.0 nM
CC(=O)N1CCN(c2ccc(CCc3cc(F)cc(-c4ccncc4)c3)cc2)CC1 CHEMBL4279912 IC50 21.0 nM
N#Cc1cccc(S(=O)(=O)N2CCN(c3ccc(/C=C/c4cc(Cl)cc(Cn5ccnc5)c4)cc3)CC2)c1 CHEMBL4292267 IC50 21.0 nM
Cc1c(/C=C/[C@H](C)c2c[nH]cn2)sc2ccc(F)cc12 CHEMBL5399419 IC50 21.0 nM
CC(C)C(O)(c1ccc2c3c(ccc2c1)C(=O)N(C)C3)c1c[nH]cn1 CHEMBL1682901 IC50 22.0 nM
CC[C@](O)(c1ccc(-c2cccc(NC(C)=O)c2)cc1)c1c[nH]cn1 CHEMBL1766191 IC50 22.0 nM
O=C1N(c2cc(C(F)(F)F)ccn2)CCN1c1cnccc1C1CC1 CHEMBL3677930 IC50 22.0 nM
Cc1cc(N2CCN(c3cnccc3C3CC3)C2=O)ncc1F CHEMBL3677965 IC50 22.0 nM
N#Cc1cccc(C(=O)N2CCN(c3ccc(/C=C/c4cc(Cl)cc(Cn5ccnc5)c4)cc3)CC2)c1 CHEMBL4283190 IC50 22.0 nM
C[C@]12CC[C@H](O)CC1=C(C(N)=O)C[C@@H]1[C@@H]2CC[C@]2(C)C(c3cccnc3)=CC[C@@H]12 CHEMBL4210141 IC50 22.8 nM
C[C@]12CC[C@H](O)CC1=CCC1C2CC[C@]2(C)C(n3cncn3)=CCC12 CHEMBL310822 Ki 23.0 nM
C[C@]12CC[C@H](O)CC1=CCC1C2CC[C@@]2(C)C1CC[C@@H]2c1cccnc1 CHEMBL82926 IC50 23.0 nM
C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(n3cncn3)=CC[C@@H]12 CHEMBL3415117 Ki 23.0 nM
NS(=O)(=O)c1cccc(-n2ncc3c(-c4cncc5ccccc45)ccnc32)c1 CHEMBL3953640 IC50 23.0 nM
Fc1ccc(-n2ncc3c(-c4cncnc4C4CC4)ccnc32)cc1 CHEMBL5289188 IC50 23.0 nM
Oc1ccc2sc3c(c2c1)CCN(Cc1cccnc1)C3 CHEMBL4064141 IC50 23.7 nM
C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(c3c[nH]cn3)=CC[C@@H]12 CHEMBL2112526 IC50 24.0 nM
COC(=O)c1ccc2cc(C(O)(c3c[nH]cn3)C(C)C)ccc2c1 CHEMBL1682891 IC50 24.0 nM
CC(=O)Nc1cccc(-c2ccc(C(O)(c3c[nH]cn3)C(C)C)cc2)c1 CHEMBL1766176 IC50 24.0 nM
CCS(=O)(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4128449 IC50 24.0 nM
Cc1ccncc1-c1ccnc2c1cnn2-c1ccc(F)c(Cl)c1 CHEMBL5287403 IC50 24.0 nM
Fc1ccc2sc3c(c2c1)CCN(Cc1c[nH]cn1)C3 CHEMBL4068802 IC50 24.3 nM
N#Cc1cccc(CN2CCN(c3ccc(/C=C/c4cc(Cl)cc(Cn5ccnc5)c4)cc3)CC2)c1 CHEMBL4279727 IC50 25.0 nM
CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL157101 IC50 26.0 nM
CC(=O)Nc1cccc(-c2ccc([C@](O)(c3c[nH]cn3)C(C)C)cc2)c1 CHEMBL1766187 IC50 26.0 nM
CC(=O)Nc1cccc(-c2ccc([C@](O)(c3c[nH]cn3)C(C)C)cc2)n1 CHEMBL1766189 IC50 26.0 nM
O=C1N(c2ccc3sc(F)cc3c2)CCN1c1cnccc1C1CC1 CHEMBL3677935 IC50 26.0 nM
O=C1N(c2ccc3ccccc3c2)CCN1c1cnccc1C1CC1 CHEMBL3677925 IC50 26.0 nM
Cc1ccncc1-c1ccc(NS(C)(=O)=O)cc1C(F)(F)F CHEMBL3666709 IC50 26.0 nM
O=C(c1cccnc1)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4294598 IC50 26.0 nM
C[C@]12CC[C@H](O)CC1=CCC1C2CC[C@@]2(C)C1CC[C@H]2c1ccncc1 CHEMBL357811 IC50 27.0 nM
COc1ccc2ccc(-c3cccnc3)c(Cl)c2c1 CHEMBL371430 IC50 27.0 nM
CC(C)C(O)(c1ccc(-c2ccc(F)cc2)cc1)c1c[nH]cn1 CHEMBL1766174 IC50 27.0 nM
C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CC[C@H]2c1ccncc1 CHEMBL3218783 IC50 27.0 nM
O=C1N(c2cccc(C(F)(F)F)c2)CCN1c1cnccc1C1(O)CC1 CHEMBL3677959 IC50 27.0 nM
COc1cc(NS(=O)(=O)c2cccc3cccnc23)ccc1-c1cncc2ccccc12 CHEMBL3662061 IC50 27.0 nM
CN(C)C(=O)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccccc4Cl)OC3)cc2)CC1 CHEMBL4281307 IC50 27.0 nM
Cc1ccncc1-c1ccnc2c1cnn2-c1cccc(F)c1 CHEMBL5265915 IC50 27.0 nM
COc1ccc2cc([C@](O)(c3c[nH]cn3)C(C)C)ccc2c1 CHEMBL1682887 IC50 28.0 nM
CC(=O)c1ccc2cc(C(O)(c3c[nH]cn3)C(C)C)ccc2c1 CHEMBL1682888 IC50 28.0 nM
CC(C)C(O)(c1ccc(-c2ccc(Cl)cc2)cc1)c1c[nH]cn1 CHEMBL1766175 IC50 28.0 nM
NC(=O)c1ccc2cc(C3(O)CCn4cncc43)ccc2c1 CHEMBL1921981 IC50 29.0 nM
Fc1ccc2sc3c(c2c1)CCN(Cc1cccnc1)C3 CHEMBL4101612 IC50 29.0 nM
CC(C)C(O)(c1ccc2cc(C(N)=O)ccc2c1)c1c[nH]cn1 CHEMBL1682892 IC50 30.0 nM
O=C1N(c2ccc3cc(F)sc3c2)CCN1c1cnccc1C1CC1 CHEMBL3677946 IC50 30.0 nM
O=S(=O)(CCCCl)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4286077 IC50 31.0 nM
Cc1ccncc1-c1ccc(NS(C)(=O)=O)cc1OCC(F)F CHEMBL3662055 IC50 32.0 nM
CC(C)C(O)(c1ccc(-c2ccccc2)cc1)c1c[nH]cn1 CHEMBL1766172 IC50 33.0 nM
Clc1ccc([C@]2(Cn3ccnc3)OC[C@@H](OCc3ccc(-c4ccncc4)cc3)CO2)c(Cl)c1 CHEMBL4290805 IC50 33.0 nM
O=S(=O)(C1CC1)N1CCN(c2ccc(/C=C/c3cc(F)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4125765 IC50 34.0 nM
CC(C(=O)OC12CC3CC(CC(C3)C1)C2)c1cccnc1 CHEMBL134509 IC50 35.0 nM
CCC(CC)(C(=O)OC1CC2CC([C@@H]1C)C2(C)C)c1ccncc1 CHEMBL132380 IC50 35.0 nM
CC(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cc4cccnc4)c3)cc2)CC1 CHEMBL4281653 IC50 35.0 nM
CNC(=O)Nc1ccc2cc(C(O)(c3c[nH]cn3)C(C)C)ccc2c1 CHEMBL1682890 IC50 36.0 nM
CC(C)C(O)(c1ccc2cc3c(cc2c1)CNC3=O)c1c[nH]cn1 CHEMBL1682902 IC50 36.0 nM
CC(=O)Nc1cccc(-c2ccc(C(O)(c3c[nH]cn3)C(C)C)cc2)n1 CHEMBL1766182 IC50 36.0 nM
O=C1N(c2ccnc(C3CC3)n2)CCN1c1cnccc1C1CC1 CHEMBL3677966 IC50 36.0 nM
CC(C)=C(c1ccncc1)c1ccc(-c2ccc(O)c(O)c2)cc1 CHEMBL1172847 IC50 37.0 nM
Cc1ccncc1-c1cccc2c1ncn2-c1cnccn1 CHEMBL2147035 IC50 37.0 nM
C[C@@H]1CCC2C(C)(C)C3CC21CC[C@@]3(C)OC(=O)Cc1cccnc1 CHEMBL135095 IC50 38.0 nM
CC(C)=C(c1ccncc1)c1ccc(-c2cccc(N)c2)cc1 CHEMBL1173326 IC50 38.0 nM
CCCNC(=O)c1ccc2cc(C(O)(c3c[nH]cn3)C(C)C)ccc2c1 CHEMBL1682895 IC50 38.0 nM
CC(=O)Nc1cccc(-c2ccc(C(C)(O)c3c[nH]cn3)cc2)c1 CHEMBL1766183 IC50 38.0 nM
CNC(=O)c1ccc2cc(C3(O)CCn4cncc43)ccc2c1 CHEMBL1921977 IC50 38.0 nM
CC(C)S(=O)(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4279221 IC50 38.0 nM
C[C@]12CCC(=O)C=C1CCC1C2CC[C@]2(C)C(c3ccno3)=CCC12 CHEMBL78215 IC50 39.0 nM
CC(=O)Nc1ccc2cc(C(O)(c3c[nH]cn3)C(C)C)ccc2c1 CHEMBL1682889 IC50 39.0 nM
CNC(=O)c1cc2ccc(C(O)(c3c[nH]cn3)C(C)C)cc2cc1C CHEMBL1682899 IC50 39.0 nM
CS(=O)(=O)Nc1ccc(-c2cnccc2C2CC2)c(C(F)(F)F)c1 CHEMBL3666711 IC50 39.0 nM
CC(C)S(=O)(=O)N1CCN(c2ccc(/C=C/c3cc(F)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4127378 IC50 39.0 nM
CC12CCC(O)CC1=CCC1C2CCC2(C)C(c3c[nH]cn3)=CCC12 CHEMBL134644 IC50 40.0 nM
CCC(O)(c1ccc(-c2cccc(NC(C)=O)c2)cc1)c1c[nH]cn1 CHEMBL1766184 IC50 40.0 nM
Cc1ccncc1-c1cccc2c1ncn2-c1cccc(C(F)(F)F)n1 CHEMBL2147036 IC50 40.0 nM
CS(=O)(=O)Nc1ccc(-c2cncc3ccccc23)c(OCCF)c1 CHEMBL3666706 IC50 40.0 nM
CCOC(=O)CNC(=O)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccccc4Cl)OC3)cc2)CC1 CHEMBL4278033 IC50 40.0 nM
C[C@]12CCC(=O)C=C1CCC1C2CC[C@]2(C)C(n3cncn3)=CCC12 CHEMBL307729 Ki 41.0 nM
C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@]2(C)C(n3cncn3)=CC[C@@H]12 CHEMBL3415123 Ki 41.0 nM
Cc1nc(Cl)cc(N2CCN(c3cnccc3C3CC3)C2=O)n1 CHEMBL3677929 IC50 41.0 nM
Cc1ccncc1-c1ccnn2c(-c3ccccc3)cnc12 CHEMBL3956116 IC50 41.0 nM
Fc1ccc(-n2ncc3c(-c4cncc5ncccc45)ccnc32)cc1 CHEMBL3893796 IC50 41.0 nM
C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(c3cc[nH]n3)=CC[C@@H]12 CHEMBL2112517 IC50 42.0 nM
O=c1c2ccccc2oc2c(Br)ccc(Cn3ccnc3)c12 CHEMBL78322 Inhibition 42.0 nM
COc1cc(N2CCN(c3cnccc3C3CC3)C2=O)ccn1 CHEMBL3677931 IC50 42.0 nM
Cc1ccncc1-c1ccc(NS(C)(=O)=O)cc1OCC(F)(F)F CHEMBL3662056 IC50 42.0 nM
Clc1ccccc1-c1noc2c(-c3cncnc3-n3cncn3)cccc12 CHEMBL3696105 IC50 42.0 nM
CC[C@@H]([C@H](C)O)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@@H]5CO[C@@](Cn6cncn6)(c6ccc(F)cc6F)C5)cc4)CC3)cc2)c1=O CHEMBL1397 IC50 42.0 nM
Fc1cc(/C=C/c2ccc(N3CCN(C4=NCCCO4)CC3)cc2)cc(Cn2ccnc2)c1 CHEMBL4127969 IC50 42.0 nM
CC(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4129703 IC50 42.0 nM
Fc1cc(/C=C/c2ccc(Br)cc2)cc(-c2ccncc2)c1 CHEMBL4284598 IC50 42.0 nM
Clc1ccccc1[C@]1(Cn2ccnc2)OC[C@@H](OCc2ccc(-c3ccncc3)cc2)CO1 CHEMBL4279058 IC50 42.0 nM
CNC(=O)c1cccc(-c2ccc(C(O)(c3c[nH]cn3)C(C)C)cc2)c1 CHEMBL1766178 IC50 44.0 nM
CC(=O)Nc1cccc(-c2ccc(C(O)(c3c[nH]cn3)C3CC3)cc2)c1 CHEMBL1766185 IC50 45.0 nM
O=C1N(c2ccnc(Cl)c2)CCN1c1cnccc1C1(O)CCC1 CHEMBL3677956 IC50 45.0 nM
COc1cncc(CN2CCc3c(sc4ccc(F)cc34)C2)c1 CHEMBL4063960 IC50 45.0 nM
Fc1cncc(CN2CCc3c(sc4ccc(F)cc34)C2)c1 CHEMBL4091726 IC50 45.4 nM
CCNC(=O)c1ccc2cc(C(O)(c3c[nH]cn3)C(C)C)ccc2c1 CHEMBL1682894 IC50 46.0 nM
Fc1ccc(-n2ncc3c(-c4cncnc4NC4CC4)ccnc32)cc1 CHEMBL5275896 IC50 46.0 nM
CNC(=O)c1ccc2cc([C@]3(O)CCn4cncc43)ccc2c1 CHEMBL1921985 IC50 48.0 nM
O=C1N(c2cc(C3CC3)ncn2)CCN1c1cnccc1C1CC1 CHEMBL3677961 IC50 48.0 nM
CS(=O)(=O)Nc1ccc(-c2cncc3ccccc23)c(C(F)(F)F)c1 CHEMBL3666710 IC50 48.0 nM
Clc1ccncc1-c1cccc2c(C3CC3)noc12 CHEMBL3696104 IC50 48.0 nM
CC(=O)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL75 IC50 48.0 nM
O=C(C1CC1)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4280777 IC50 48.0 nM
CC(C)C(O)(c1cccc(-c2ccc(Cl)cc2)c1)c1c[nH]cn1 CHEMBL1766171 IC50 49.0 nM
CCc1ncncc1-c1ccc(NS(C)(=O)=O)cc1OC CHEMBL3666699 IC50 49.0 nM
C[C@]12CCC(=O)C=C1CCC1C2CC[C@]2(C)C(c3c[nH]cn3)=CCC12 CHEMBL325307 IC50 50.0 nM
COc1cc2ccc(C(O)(c3c[nH]cn3)C(C)C)cc2cc1OC CHEMBL3264604 IC50 50.0 nM
C[C@]12CC(O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)C(n3ccnn3)=CC[C@@H]12 CHEMBL3972629 IC50 50.0 nM
Cn1cncc1-c1ccnc2c1cnn2-c1ccc(F)cc1 CHEMBL3902750 IC50 50.0 nM
CS(=O)(=O)Nc1ccc(-c2cncc3ncccc23)c(OCCF)c1 CHEMBL3666708 IC50 51.0 nM
C[C@@H]1CCC2C(C)(C)C3CC21CC[C@@]3(C)OC(=O)Cc1ccncc1 CHEMBL134442 IC50 52.0 nM
CCC(c1ccc(-c2ccc(O)c(O)c2)cc1F)n1ccnc1 CHEMBL571003 IC50 52.0 nM
Oc1ccc(-c2ccc(Cc3ccncc3)cc2)cc1O CHEMBL1172779 IC50 52.0 nM
Cc1cc(NS(C)(=O)=O)ccc1-c1cnccc1Cl CHEMBL3666696 IC50 52.0 nM
C[C@]12CC[C@H](O)CC1=CCC1C2CC[C@@]2(C)C1CC[C@@H]2c1ccncc1 CHEMBL310690 IC50 53.0 nM
Nc1ccc(SC[C@H]2CO[C@@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1 CHEMBL305220 Ki 54.0 nM
COc1ccc(-c2ccc(C(O)(c3c[nH]cn3)C(C)C)cc2)cc1 CHEMBL1766173 IC50 54.0 nM
CCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL1170 IC50 56.0 nM
CC(C)=C(c1ccncc1)c1ccc(-c2cccc(O)c2)cc1 CHEMBL1173259 IC50 56.0 nM
COc1ccc(S(=O)(=O)Nc2ccc(-c3cncnc3C)c(OC)c2)cc1 CHEMBL3666690 IC50 56.0 nM
COc1ccncc1-c1ccc(NS(C)(=O)=O)cc1OCC(F)(F)F CHEMBL3666705 IC50 56.0 nM
Fc1ccc(-c2csc3c(-c4cncc5ccccc45)cccc23)cc1 CHEMBL3696113 IC50 56.0 nM
Cc1ccncc1-c1ccnn2c(-c3ccc(F)cc3)cnc12 CHEMBL3899573 IC50 56.0 nM
c1ccc(-c2ccc(C(c3ccccc3)n3ccnc3)cc2)cc1 CHEMBL277535 Ki 56.5 nM
COc1cc(NS(C)(=O)=O)ccc1-c1cncnc1OC CHEMBL3666712 IC50 57.0 nM
C[C@]12CCC(=O)C=C1CCC1C2CC[C@@]2(C)C1CC[C@@H]2c1c[nH]cn1 CHEMBL113966 IC50 58.0 nM
O=C1N(c2ccc3c(c2)OC(F)(F)O3)CCN1c1cnccc1C1CC1 CHEMBL3677938 IC50 58.0 nM
CS(=O)(=O)N1CCN(c2ccc(/C=C/c3cc(F)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4125996 IC50 58.0 nM
C[C@]12CCC(=O)C=C1CCC1C2CC[C@]2(C)C(c3cc[nH]n3)=CCC12 CHEMBL113448 IC50 59.0 nM
COc1cc(NS(=O)(=O)c2ccc3ccccc3c2)ccc1-c1cncnc1C CHEMBL3666693 IC50 59.0 nM
CS(=O)(=O)Nc1ccc(-c2cncc3ccccc23)c(OCC(F)(F)F)c1 CHEMBL3666704 IC50 59.0 nM
CC(C)=C(c1ccncc1)c1ccc(-c2ccc3cc(O)ccc3c2)cc1 CHEMBL1172842 IC50 62.0 nM
C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CC[C@@H]2n1ccnc1 CHEMBL3415127 IC50 62.0 nM
Oc1ccc(-c2ccc3c(c2)CCCC3c2ccncc2)cc1F CHEMBL496469 IC50 64.0 nM
Oc1ccc2ccc(-c3cccnc3)c(Cl)c2c1 CHEMBL2420674 IC50 64.0 nM
FC(F)(F)COc1ncncc1-c1cccc2c(-c3cnccn3)noc12 CHEMBL3696103 IC50 65.0 nM
C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CC[C@@H]2c1c[nH]cn1 CHEMBL2112518 IC50 66.0 nM
O=S(=O)(N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1)C(F)(F)F CHEMBL3938615 IC50 67.0 nM
O=S(=O)(c1c[nH]cn1)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)OC3)cc2)CC1 CHEMBL4288383 IC50 67.0 nM
Cc1cc(N2CCN(c3cnccc3C3CC3)C2=O)ncn1 CHEMBL3677964 IC50 70.0 nM
C[C@]12CC[C@H](O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](c3cccnc3)CC[C@@H]12 CHEMBL3137965 IC50 74.0 nM
C[C@@H](OC(=O)C12CC3CC(CC(C3)C1)C2)c1ccncc1 CHEMBL112292 IC50 74.0 nM
CC(C)C(O)(c1ccc2cc(OC(F)F)ccc2c1)c1c[nH]nn1 CHEMBL3264608 IC50 74.0 nM
CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@@H]2CC[C@]2(C)C(c4c[nH]cn4)=CC[C@@H]32)C1 CHEMBL2112534 IC50 75.0 nM
CC(C)=C(c1ccncc1)c1ccc(-c2ccc(O)c(F)c2)cc1 CHEMBL1173335 IC50 75.0 nM
CC(C)=C(c1ccncc1)c1ccc(-c2ccc(N)c(N)c2)cc1 CHEMBL1171991 IC50 75.0 nM
CC(C)NC(=O)c1ccc2cc(C(O)(c3c[nH]cn3)C(C)C)ccc2c1 CHEMBL1682896 IC50 75.0 nM
N#Cc1cccc(S(=O)(=O)N2CCN(c3ccc(CO[C@H]4CO[C@](Cn5ccnc5)(c5ccc(Cl)cc5Cl)OC4)cc3)CC2)c1 CHEMBL4279441 IC50 75.0 nM
C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(c3ccccn3)=CC[C@@H]12 CHEMBL2112301 IC50 76.0 nM
Cc1csc2cc(N3CCN(c4cnccc4C4CC4)C3=O)ccc12 CHEMBL3677939 IC50 76.0 nM
Cc1ccncc1-c1ccnc2c(-c3nccs3)csc12 CHEMBL3696109 IC50 76.0 nM
Fc1ccc(-n2ncc3c(-c4cncn5cccc45)ccnc32)c(F)c1 CHEMBL3925996 IC50 76.0 nM
C[C@]12CC[C@H](O)CC1=CC[C@H]1C3CC/C(=C/C=N\O)[C@@]3(C)CC[C@@H]12 CHEMBL2112731 IC50 77.0 nM
CC(=O)Nc1cccc(-c2ccc(C(O)c3c[nH]cn3)cc2)c1 CHEMBL1766186 IC50 77.0 nM
COc1ccc(COc2noc3c(-c4cnccc4C)cccc23)cc1 CHEMBL3696116 IC50 79.0 nM
Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 CHEMBL104 Ki 81.5 nM
c1ccc(-c2nnc3n2-c2ccc(-c4cccnc4)cc2CC3)cc1 CHEMBL3622434 IC50 84.0 nM
COc1cc(N2CCN(c3cnccc3C3CC3)C2=O)ncn1 CHEMBL3677963 IC50 84.0 nM
N#CCS(=O)(=O)N1CCN(c2ccc(/C=C/c3cc(F)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4125902 IC50 86.0 nM
C[C@@H]1C(OC(=O)Cc2cccnc2)CC2CC1C2(C)C CHEMBL131984 IC50 88.0 nM
CNC(=O)c1ccc2cc(C3(O)c4cncn4CC3(C)C)ccc2c1 CHEMBL1921978 IC50 88.0 nM
CC(=O)N1CCN(c2ccc(/C=C/c3cc(O)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4282398 IC50 88.0 nM
CCC(c1ccc(-c2ccc(O)cc2)cc1F)n1ccnc1 CHEMBL556280 IC50 90.0 nM
Cc1ccncc1-c1ccnc2c1cnn2CC(F)(F)F CHEMBL5267919 IC50 90.0 nM
Cc1ccncc1-c1ccnc2c1cnn2-c1nccs1 CHEMBL5267699 IC50 91.0 nM
CC(C)(OC(=O)C12CC3CC(CC(C3)C1)C2)c1cccnc1 CHEMBL431843 IC50 92.0 nM
CC(=O)Nc1cccc(-c2ccc([C@@](O)(c3c[nH]cn3)C(C)C)cc2)n1 CHEMBL1766190 IC50 92.0 nM
Cc1ccncc1-c1ccnc2c1cnn2C(C)(C)C CHEMBL5276101 IC50 92.0 nM
COc1cncc(-c2ccc3ccc(OC)cc3c2Cl)c1 CHEMBL2420681 IC50 94.0 nM
Fc1ccc(-n2ncc3c(-c4cccnc4)ccnc32)cc1 CHEMBL5267526 IC50 96.0 nM
Oc1cccc(-c2ccc(Cc3ccncc3)cc2)c1 CHEMBL1172882 IC50 97.0 nM
Cc1ccncc1-c1ccnn2c(-c3cccc(Cl)c3)cnc12 CHEMBL3908531 IC50 97.0 nM
CC(c1ccc2c(c1)Cc1cc(O)ccc1-2)n1ccnc1 CHEMBL505550 IC50 99.0 nM
O=C1N(c2ccnc(C(F)(F)F)n2)CCN1c1cnccc1C1CC1 CHEMBL3677933 IC50 99.0 nM
Nc1ncncc1-c1ccnc2c1cnn2-c1cccc(S(N)(=O)=O)c1 CHEMBL5276695 IC50 99.0 nM
CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@H]3[C@@H]4CC[C@H](C5=CNC(C(C)=O)N5)[C@@]4(C)CC[C@@H]32)C1 CHEMBL2112524 IC50 100.0 nM
C/C(=N/O)C1=CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C CHEMBL135351 IC50 100.0 nM
COc1cc(NS(=O)(=O)CC(C)C)ccc1-c1cncnc1C CHEMBL3662069 IC50 100.0 nM
COc1cc(NS(C)(=O)=O)ccc1-c1cncnc1C1CCCCC1 CHEMBL3666701 IC50 100.0 nM
Clc1cc(/C=C/c2ccc(N3CCN(C4=NCCO4)CC3)cc2)cc(Cn2ccnc2)c1 CHEMBL4129210 IC50 100.0 nM
Cc1cn(C2=CCC3C4CC=C5C[C@@H](NC(=O)c6ccc(F)cc6)CC[C@]5(C)C4CC[C@]23C)cn1 CHEMBL5400213 IC50 100.0 nM
O=S(=O)(c1cccc(OC(F)(F)F)c1)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)OC3)cc2)CC1 CHEMBL4284316 IC50 101.0 nM
COc1cc(NS(C)(=O)=O)ccc1-c1cncnc1C(C)C CHEMBL3666700 IC50 103.0 nM
Cc1cc(NS(C)(=O)=O)ccc1-c1cnccc1-c1ccccc1 CHEMBL3662054 IC50 104.0 nM
COc1ccc2ccc(-c3cccnc3)c(F)c2c1 CHEMBL2420675 IC50 106.0 nM
O=C1N(c2ccc3sc(Cl)cc3c2)CCN1c1cnccc1C1CC1 CHEMBL3677941 IC50 106.0 nM
O=[N+]([O-])c1cc(S(=O)(=O)N2CCN(c3ccc(/C=C/c4cc(Cl)cc(Cn5ccnc5)c4)cc3)CC2)ccc1Cl CHEMBL4293278 IC50 106.0 nM
O=S(=O)(CCCCl)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)OC3)cc2)CC1 CHEMBL4284620 IC50 106.0 nM
C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(c3ccno3)=CC[C@@H]12 CHEMBL2112521 IC50 108.0 nM
COc1ccc2c(c1)CCC(Cc1cnc[nH]1)=C2C CHEMBL390569 IC50 110.0 nM
CCCn1nnc2cc(-c3cc(-c4ccncc4)c(C#N)c(N)n3)ccc21 CHEMBL5429337 IC50 110.0 nM
COc1cc(NS(C)(=O)=O)ccc1-c1cncnc1C CHEMBL3662066 IC50 112.0 nM
COc1cc(NS(=O)(=O)c2ccc(Cl)cc2)ccc1-c1cncnc1C CHEMBL3666691 IC50 117.0 nM
Fc1cc(/C=C/c2ccc(N3CCN(C4=NCCO4)CC3)cc2)cc(Cn2ccnc2)c1 CHEMBL4129355 IC50 117.0 nM
CC(c1ccc2c(c1)[nH]c1cc(F)ccc12)n1ccnc1 CHEMBL454217 IC50 118.0 nM
COc1cc(NS(=O)(=O)c2cn(C)c(C)n2)ccc1-c1cncc2ccccc12 CHEMBL3662063 IC50 118.0 nM
COc1cc(NS(=O)(=O)c2cccc3cccnc23)ccc1-c1cncnc1C CHEMBL3666694 IC50 118.0 nM
COc1cc(NS(=O)(=O)CCc2ccccc2)ccc1-c1cncnc1C CHEMBL3666689 IC50 119.0 nM
CC(=O)Nc1ccc(-c2ccc(C(O)(c3c[nH]cn3)C(C)C)cc2)cc1 CHEMBL1766177 IC50 120.0 nM
COc1cc(NS(C)(=O)=O)ccc1-c1cncn2cccc12 CHEMBL3666713 IC50 120.0 nM
Cc1cccc(-c2cnc3c(-c4cnccc4C)ccnn23)c1 CHEMBL3972117 IC50 120.0 nM
O=C1N(c2cc(Cl)ncn2)CCN1c1cnccc1C1CC1 CHEMBL3677932 IC50 121.0 nM
Cc1cn(C2=CCC3C4CC=C5C[C@@H](NC(=O)c6ccc(F)cc6F)CC[C@]5(C)C4CC[C@]23C)cn1 CHEMBL5413706 IC50 127.0 nM
Fc1ccc(-n2ncc3c(-c4cncc5ccccc45)ccnc32)cc1 CHEMBL3892696 IC50 128.0 nM
Cc1ccncc1-c1ccnn2c(-c3cccc(C(F)(F)F)c3)cnc12 CHEMBL3958248 IC50 129.0 nM
O=C(Cc1cccnc1)OC12CC3CC(CC(C3)C1)C2 CHEMBL135037 IC50 130.0 nM
O=c1c2ccccc2oc2c([N+](=O)[O-])ccc(Cn3ccnc3)c12 CHEMBL307160 IC50 130.0 nM
COc1ccc(-c2cccc(C(O)(c3c[nH]cn3)C(C)C)c2)cc1 CHEMBL1765101 IC50 130.0 nM
COc1cc(NS(=O)(=O)c2cccnc2)ccc1-c1cncnc1C CHEMBL3662071 IC50 131.0 nM
CCCS(=O)(=O)Nc1ccc(-c2cncnc2C)c(OC)c1 CHEMBL3662068 IC50 134.0 nM
CCOc1ncncc1-c1cccc2c1ncn2CC(F)(F)F CHEMBL2147046 IC50 135.0 nM
CC(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(COc4cccnc4)c3)cc2)CC1 CHEMBL4288970 IC50 135.0 nM
Fc1ccc(-n2ncc3c(-c4cncnc4C(F)(F)F)ccnc32)cc1 CHEMBL5284019 IC50 141.0 nM
Oc1ccc(-c2ccc3c(c2)CCCC3c2ccncc2)cc1O CHEMBL522228 IC50 144.0 nM
CC(=O)N1CCN(c2ccc(CO[C@H]3CO[C@](Cn4ccnc4)(c4ccccc4Cl)OC3)cc2)CC1 CHEMBL4283034 IC50 146.0 nM
COc1ccc2ccc(-c3cccnc3)c(Cl)c2c1F CHEMBL2420677 IC50 147.0 nM
C[C@]12CCC(O)CC1=CCC1C2CC[C@]2(C)C(c3ccnn3-c3ccccc3)=CCC12 CHEMBL114864 IC50 150.0 nM
C[C@]12CCC3C(CC=C4CC(O)CC[C@@]43C)C1CCC2c1cc[nH]n1 CHEMBL115944 IC50 150.0 nM
Cn1ccc(C2=CCC3C4CC=C5CC(O)CC[C@]5(C)C4CC[C@]23C)n1 CHEMBL325895 IC50 150.0 nM
Cn1nccc1C1=CCC2C3CC=C4CC(O)CC[C@]4(C)C3CC[C@]12C CHEMBL333604 IC50 150.0 nM
C[C@]12CCC3C(CC=C4CC(O)CC[C@@]43C)C1CCC2c1ccno1 CHEMBL113804 IC50 150.0 nM
C[C@@H](OC(=O)C12CC3CC(CC(C3)C1)C2)c1cccnc1 CHEMBL325461 IC50 150.0 nM
CC(C)C(O)(c1ccc(-c2ccccn2)cc1)c1c[nH]cn1 CHEMBL1766181 IC50 150.0 nM
C[C@]12CC[C@H](O)C[C@@H]1/C(=N/O)C[C@@H]1[C@@H]2CC[C@]2(C)C(c3cccnc3)=CC[C@@H]12 CHEMBL4280255 IC50 150.0 nM
CCC(c1ccc(-c2ccc(O)c(O)c2)cc1)n1ccnc1 CHEMBL551253 IC50 152.0 nM
COc1cc(NS(=O)(=O)CC(F)(F)F)ccc1-c1cncnc1C CHEMBL3666687 IC50 158.0 nM
C[C@@H](C=O)C1CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@@]21C CHEMBL137415 IC50 160.0 nM
CNC(=O)c1ccc2cc(C(O)(c3c[nH]cn3)C(C)C)ccc2c1C CHEMBL1682898 IC50 160.0 nM
CNS(=O)(=O)c1cccc(-c2ccc(C(O)(c3c[nH]cn3)C(C)C)cc2)c1 CHEMBL1766179 IC50 160.0 nM
O=C1N(c2ccnc(Cl)c2)[C@@H]2C[C@@H]2N1c1cnccc1C1CC1 CHEMBL3677950 IC50 161.0 nM
Fc1ccc(-c2ccc3c(c2)CCCC3c2ccncc2)cc1 CHEMBL496289 IC50 163.0 nM
CCC(c1ccc(-c2cccc(O)c2)cc1)n1ccnc1 CHEMBL556833 IC50 164.0 nM
CC(c1ccc2c(c1)Cc1cc(F)ccc1-2)n1ccnc1 CHEMBL501460 IC50 168.0 nM
COc1cc(N2C(=O)N(c3cnccc3C3CC3)[C@H]3C[C@H]32)ccn1 CHEMBL3677952 IC50 169.0 nM
COc1cc(NS(=O)(=O)C2CC2)ccc1-c1cncnc1C CHEMBL3662067 IC50 169.0 nM
C/C(=N/O)C1=CCC2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL2112737 IC50 170.0 nM
CC(C)C(O)(c1ccc2cc(OC(F)F)c(OC(F)F)cc2c1)c1cnn[nH]1 CHEMBL3264605 IC50 170.0 nM
CS(=O)(=O)Nc1ccc(-c2cnccc2Cl)c(OCCF)c1 CHEMBL3666707 IC50 174.0 nM
C[C@]12CC[C@H](O)CC1=CCC1C2CC[C@]2(C)/C(=N/NC(N)=O)CCC12 CHEMBL77751 IC50 178.2 nM
C[C@@H](O)C1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@@]21C CHEMBL137623 IC50 180.0 nM
C[C@]12CC[C@H](O)C=C1CC[C@H]1C3CC/C(=C/C=N\O)[C@@]3(C)CC[C@@H]12 CHEMBL2112735 IC50 180.0 nM
COc1cc2ccc(C(O)(c3cnn[nH]3)C(C)C)cc2cc1OC CHEMBL3264597 IC50 180.0 nM
CS(=O)(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(Cn4ccnc4)c3)cc2)CC1 CHEMBL4126412 IC50 180.0 nM
C[C@]12CC[C@H](O)CC1=C([N+](=O)[O-])C[C@@H]1[C@@H]2CC[C@]2(C)C(c3cccnc3)=CC[C@@H]12 CHEMBL4293668 IC50 183.0 nM
O=C1N(c2ccnc(C(F)(F)F)c2)[C@@H]2C[C@@H]2N1c1cnccc1C1CC1 CHEMBL3677954 IC50 184.0 nM
COc1cncc(-c2ccc3ccc(O)cc3c2Cl)c1 CHEMBL2420682 IC50 185.0 nM
Brc1cc(Br)c2oc(Cn3ccnc3)cc2c1 CHEMBL5403643 IC50 185.0 nM
Oc1ccc(-c2ccc(Cc3ccncc3)cc2)cc1F CHEMBL1173260 IC50 186.0 nM
Cc1ncncc1-c1ccnc2c1cnn2-c1ccc(F)cc1 CHEMBL5278006 IC50 186.0 nM
Oc1ccc(-c2ccc3c(c2)CCC=C3c2ccncc2)cc1F CHEMBL496286 IC50 188.0 nM
CCC(c1ccc(-c2cccc(OC)c2)cc1)n1ccnc1 CHEMBL540997 IC50 188.0 nM
CCC(c1ccncc1)c1ccc(-c2cccc(O)c2)cc1 CHEMBL1172883 IC50 189.0 nM
CCNC(=O)c1ccc2cc(C3(O)CCn4cncc43)ccc2c1 CHEMBL1921982 IC50 190.0 nM
Fc1cc(CCc2ccc(-c3ccncc3)cc2)cc(-c2ccncc2)c1 CHEMBL4288457 IC50 190.0 nM
Fc1ccc(-c2noc3c(-c4cncn5cccc45)cccc23)cc1 CHEMBL3696102 IC50 192.0 nM
CCC(c1ccc(-c2cc(O)cc(O)c2)cc1)n1ccnc1 CHEMBL565098 IC50 195.0 nM
CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@H]3[C@@H]4CC[C@H](c5c[nH]cn5)[C@@]4(C)CC[C@@H]32)C1 CHEMBL2112528 IC50 199.0 nM
C[C@]12CC[C@H](O)C[C@@H]1n1nnnc1C[C@@H]1[C@@H]2CC[C@]2(C)C(c3cccnc3)=CC[C@@H]12 CHEMBL4289220 IC50 199.0 nM
C/C(=N/O)[C@H]1CC=C2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C CHEMBL2112747 IC50 200.0 nM
C/C(=N/O)C1=CC=C2C3CCC4=CC(=O)CCC4(C)C3CCC12C CHEMBL135288 IC50 200.0 nM
CNC(=O)c1ccc2cc(C(O)(c3c[nH]cn3)C(C)C)ccc2c1Cl CHEMBL1682897 IC50 200.0 nM
C[C@]12CC[C@H](O)CC1C=C[C@@H]1[C@@H]2CC[C@]2(C)C(c3cccnc3)=CC[C@@H]12 CHEMBL2392007 IC50 206.0 nM
NS(=O)(=O)c1cccc(-n2ncc3c(-c4cncc5ncccc45)ccnc32)c1 CHEMBL3971564 IC50 206.0 nM
C[C@H](NC(=O)C12CC3CC(CC(C3)C1)C2)c1ccncc1 CHEMBL110257 IC50 210.0 nM
CC(C)C(c1ccc2cc(OC(F)F)ccc2c1)n1ncnn1 CHEMBL3682507 IC50 210.0 nM
CC(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(C(=C(C)C)c4cccnc4)c3)cc2)CC1 CHEMBL4283084 IC50 210.0 nM
CCC(c1ccc(-c2ccc(O)c(Cl)c2)cc1)n1ccnc1 CHEMBL541941 IC50 217.0 nM
C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CC[C@@H]2n1cncn1 CHEMBL3415126 IC50 219.0 nM
N#Cc1ccc(Cn2ccnc2)c2c(=O)c3ccccc3oc12 CHEMBL442373 IC50 220.0 nM
CC(=O)N1CCN(c2ccc(/C=C/c3cc(O)cc(-n4ccnc4)c3)cc2)CC1 CHEMBL4280985 IC50 220.0 nM
C[C@]12CC[C@H](O)CC1=CCC1C2CC[C@@]2(C)C1CC[C@H]2c1ccncn1 CHEMBL305896 IC50 225.0 nM
Nc1cccc(-c2ccc(Cc3ccncc3)cc2)c1 CHEMBL1171987 IC50 226.0 nM
C[C@H](OC(=O)C12CC3CC(CC(C3)C1)C2)c1cccnc1 CHEMBL112509 IC50 230.0 nM
C[C@]12CC[C@H](O)C[C@@H]1NC(=O)C[C@@H]1[C@@H]2CC[C@]2(C)C(c3cccnc3)=CC[C@@H]12 CHEMBL4210952 IC50 230.0 nM
Cc1ccc(-c2csc(-c3cccnc3)n2)c(C)c1 CHEMBL5439030 IC50 230.0 nM
CCC(c1ccc(-c2ccc(O)cc2)cc1)n1ccnc1 CHEMBL500680 IC50 231.0 nM
COc1ccc2c(Cl)c(-c3cccnc3)ccc2c1Cl CHEMBL381014 IC50 233.0 nM
Fc1ccc(-c2ccc3c(c2)CCC3c2ccncc2)cc1 CHEMBL496288 IC50 233.0 nM
CCC(c1ccc(-c2cscc2C)cc1F)n1ccnc1 CHEMBL403808 IC50 236.0 nM
C[C@@H](O)C1CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@@]21C CHEMBL137463 IC50 240.0 nM
CC[C@@](O)(c1ccc(-c2cccc(NC(C)=O)c2)cc1)c1c[nH]cn1 CHEMBL1766192 IC50 240.0 nM
CC(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(C(O)(c4cccnc4)C(C)C)c3)cc2)CC1 CHEMBL4282697 IC50 240.0 nM
CC(c1ccc(-c2ccc(F)cc2)cc1)n1ccnc1 CHEMBL445171 IC50 240.0 nM
Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 CHEMBL91 Ki 243.0 nM
C[C@]12CC[C@H](O)C[C@@H]1C(C#N)=C[C@@H]1[C@@H]2CC[C@]2(C)C(c3cccnc3)=CC[C@@H]12 CHEMBL4279184 IC50 244.0 nM
Oc1ccc(-c2ccc(C(O)c3ccncc3)cc2)cc1 CHEMBL1215664 IC50 248.0 nM
Cc1ccncc1-c1cccc2c1ncn2-c1cccnn1 CHEMBL3917734 IC50 250.0 nM
Cc1ccncc1-c1cccc2c(OCc3ccc(Cl)cc3)noc12 CHEMBL3696115 IC50 251.0 nM
C[C@]12CC[C@H](O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1C[C@H]1O[C@]12c1cccnc1 CHEMBL2112888 IC50 260.0 nM
O=c1c2ccccc2oc2c(Cl)ccc(Cn3ccnc3)c12 CHEMBL2333326 IC50 260.0 nM
Clc1ccccc1[C@]1(Cn2ccnc2)OC[C@@H](OCc2ccc(N3CCOCC3)cc2)CO1 CHEMBL4286761 IC50 260.0 nM
CCC(c1ccc(-c2ccc(O)c(C)c2)cc1)n1ccnc1 CHEMBL557233 IC50 261.0 nM
CCC(c1ccc(-c2ccsc2Cl)cc1)n1ccnc1 CHEMBL403852 IC50 263.0 nM
CC12CCC(O)CC1=CCC1C2CCC2(C)C(C/C=N/O)CCC12 CHEMBL440165 IC50 270.0 nM
CC(C)[C@@](O)(c1ccc2c3c(ccc2c1)C(=O)N(C)C3)c1c[nH]cn1 CHEMBL1682905 IC50 270.0 nM
COc1cc2ccc(C(C(C)C)n3ncnn3)cc2cc1OC CHEMBL3682506 IC50 270.0 nM
Cn1cncc1-c1ccnc2c1cnn2-c1cccc(S(N)(=O)=O)c1 CHEMBL3931379 IC50 271.0 nM
Cc1cc(C)cc(-c2cnc3c(-c4cnccc4C)ccnn23)c1 CHEMBL3902101 IC50 279.0 nM
CN(C=O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL2112758 IC50 280.0 nM
CC(c1ccc2c(c1)[nH]c1ccccc12)n1ccnc1 CHEMBL499882 IC50 282.0 nM
O=C(NC1CC1)c1ccc2cc(C3(O)CCn4cncc43)ccc2c1 CHEMBL1921983 IC50 290.0 nM
COc1cc2ccc(C(O)(c3cncs3)C(C)C)cc2cc1OC CHEMBL3264599 IC50 290.0 nM
COc1ccc2ccc(-c3cncc4ccccc34)c(Cl)c2c1 CHEMBL2420687 IC50 294.0 nM
C[C@]12CC[C@H](O)CC1=CCC1C2CC[C@]2(C)C(n3cnc4ccccc43)=CCC12 CHEMBL75474 IC50 300.0 nM
CCCCC(c1ccc(-c2ccccc2)cc1)n1ccnc1 CHEMBL498523 IC50 300.0 nM
CC(C)=C(c1cccnc1)c1cc(Cl)cc(/C=C/c2ccc(-c3ccncc3)cc2)c1 CHEMBL4281147 IC50 300.0 nM
Oc1ccc(-c2ccc3c(c2)CCC=C3c2ccncc2)cc1O CHEMBL526081 IC50 307.0 nM
CC(C)C(c1ccc(-c2ccccc2)cc1)n1ccnc1 CHEMBL496468 IC50 310.0 nM
CC(C)C(O)(c1ccc2cc(OCC(F)(F)F)c(OCC(F)(F)F)cc2c1)c1c[nH]nn1 CHEMBL3264606 IC50 310.0 nM
CN1C(=O)CCc2cc(-c3cccnc3)ccc21 CHEMBL446083 pIC50 316.23 nM
CC1(OC(=O)Cc2cccnc2)C2CC3CC(C2)CC1C3 CHEMBL3084924 IC50 320.0 nM
C[C@]12CC[C@@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)/C(=C\C=N\O)CC[C@@H]12 CHEMBL2112282 IC50 320.0 nM
Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 CHEMBL808 Ki 325.0 nM
Cc1ccncc1-c1cccc2c1ncn2CC#N CHEMBL2147042 IC50 330.0 nM
OC1(c2ccncc2)CCc2cc(-c3ccc(F)cc3)ccc21 CHEMBL498472 IC50 333.0 nM
Nc1ccc(-c2ccc(Cc3ccncc3)cc2)cc1N CHEMBL1173327 IC50 337.0 nM
CC(=O)Nc1cccc(-c2ccc([C@@](O)(c3c[nH]cn3)C(C)C)cc2)c1 CHEMBL1766188 IC50 340.0 nM
O=C1N(c2ccnc(Cl)c2)CCN1c1cnccc1C1(O)CCCC1 CHEMBL3677958 IC50 341.0 nM
CCC(c1ccncc1)c1ccc(-c2ccc(O)c(F)c2)cc1 CHEMBL1173261 IC50 343.0 nM
CCC(c1ccc(-c2ccc(F)cc2)cc1)n1ccnc1 CHEMBL527112 IC50 345.0 nM
Cc1ncncc1-c1cccc2c(-c3ccccc3)noc12 CHEMBL3696100 IC50 357.0 nM
FC(F)(F)Cn1cnc2c(-c3cnccc3Cl)cccc21 CHEMBL2147044 IC50 361.0 nM
CCC(c1ccc(-c2ccsc2)cc1)n1ccnc1 CHEMBL403475 IC50 373.0 nM
Oc1ccc2ccc(-c3cccnc3)c(Cl)c2c1F CHEMBL2420678 IC50 375.0 nM
CCC(c1ccc(-c2cc(C)c(O)c(C)c2)cc1)n1ccnc1 CHEMBL557232 IC50 379.0 nM
Fc1cccc(-c2ccc(Cc3ccncc3)cc2)c1 CHEMBL1215732 IC50 386.0 nM
c1ccc2c(c1)Cc1cc(Cn3ccnc3)ccc1-2 CHEMBL502542 IC50 388.0 nM
Cc1ccncc1-c1cccc2c1ncn2C1CC1 CHEMBL2147043 IC50 396.0 nM
Cc1nccc(N2CCN(c3cnccc3C3CC3)C2=O)n1 CHEMBL3677967 IC50 397.0 nM
Cc1nc(C2CCC3C4CC=C5CC(O)CC[C@]5(C)C4CC[C@]23C)co1 CHEMBL419743 IC50 400.0 nM
Cc1nc([C@H]2CC[C@H]3[C@@H]4CC=C5C[C@@H](O)CC[C@]5(C)[C@H]4CC[C@]23C)c[nH]1 CHEMBL2112533 IC50 400.0 nM
C[C@]12CCC3C(CC=C4CC(O)CC[C@@]43C)C1CCC2c1ncc[nH]1 CHEMBL419934 IC50 400.0 nM
C[C@]12CCC(O)CC1=CCC1C2CC[C@@]2(C)C1CC[C@@H]2c1c[nH]c(-c2ccccc2)n1 CHEMBL541717 IC50 400.0 nM
C[C@]12CCC(=O)C=C1CCC1C2CC[C@@]2(C)C1CC[C@@H]2C1N=CC=N1 CHEMBL113407 IC50 400.0 nM
CC(C)NC(=O)c1ccc2cc(C3(O)CCn4cncc43)ccc2c1 CHEMBL1921984 IC50 400.0 nM
CC(C)C(O)c1ccc2cc(OCC(F)(F)F)ccc2c1 CHEMBL3682508 IC50 400.0 nM
Cc1ccncc1-c1cccc2c1ncn2-c1ccncc1 CHEMBL2147040 IC50 405.0 nM
Nc1ccc(-c2ccc(Cc3ccncc3)cc2)cc1 CHEMBL1215665 IC50 408.0 nM
CNC(=O)c1ccc2cc(C(C)(O)c3cncn3C)ccc2c1 CHEMBL1921980 IC50 410.0 nM
OC1(c2ccncc2)CCCc2cc(-c3ccc(F)c(F)c3)ccc21 CHEMBL496262 IC50 423.0 nM
C[C@]12CC[C@H]3[C@@H](C[C@@H]4O[C@@]45C[C@@H](O)CC[C@]35C)[C@@H]1CC=C2c1cccnc1 CHEMBL4294403 IC50 428.0 nM
C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC1O[C@]12c1c[nH]cn1 CHEMBL2112519 IC50 430.0 nM
C[C@@H](NC(=O)C12CC3CC(CC(C3)C1)C2)c1ccncc1 CHEMBL114019 IC50 430.0 nM
Oc1ccc2cc(-c3ccc(Cc4ccncc4)cc3)ccc2c1 CHEMBL1214739 IC50 438.0 nM
CC(=O)[C@@]12O[C@@H]1C[C@H]1[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]12C CHEMBL2112757 IC50 440.0 nM
Nc1ccc(SC[C@@H]2CO[C@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1 CHEMBL70611 Ki 447.0 nM
C[C@]12CCC3C(CC=C4C[C@@H](O)CC[C@@]43C)C1CCC2C/C=N/O CHEMBL77288 IC50 450.0 nM
CCC(c1ccc(-c2ccccc2)cc1)n1ccnc1 CHEMBL497500 IC50 450.0 nM
COc1ccc2ccc(-c3cncc(F)c3)c(Cl)c2c1 CHEMBL2420679 IC50 454.0 nM
CC(C)(C)C(c1ccc(-c2ccccc2)cc1)n1ccnc1 CHEMBL498522 IC50 460.0 nM
CC(C)C(c1ccc2cc(OCC(F)(F)F)ccc2c1)n1ncnn1 CHEMBL3682505 IC50 460.0 nM
O=C1N(c2cc3sccc3cc2F)CCN1c1cnccc1C1CC1 CHEMBL3677948 IC50 461.0 nM
CC(=O)[C@@]12O[C@@H]1C[C@H]1[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]12C CHEMBL2112759 IC50 480.0 nM
CCn1ccc2c3nc(-c4ccccc4)cc(Cn4ccnc4)c3ccc21 CHEMBL2442758 IC50 480.0 nM
C[C@]12CC[C@H](n3ccnc3)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(n3cnc4ccccc43)=CC[C@@H]12 CHEMBL4591875 IC50 480.0 nM
CC(=O)C1=CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C CHEMBL137622 IC50 490.0 nM
CC(C)=C(c1ccncc1)c1ccc(-c2ccc(NC(=O)OC(C)(C)C)cc2)cc1 CHEMBL1173727 IC50 493.0 nM
O=c1c2ccccc2oc2c(O)ccc(Cn3ccnc3)c12 CHEMBL2333336 IC50 493.0 nM
C[C@]12CC[C@H](O)CC1=CCC1C2CC[C@]2(C)C(c3cncnc3)=CCC12 CHEMBL77062 IC50 500.0 nM
Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1 CHEMBL1200438 Ki 505.0 nM
CC(O)C1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C CHEMBL137063 IC50 510.0 nM
CC(C)C(O)(c1ccc2cc(-c3cnco3)ccc2c1)c1cnn[nH]1 CHEMBL3264607 IC50 510.0 nM
CC12CCC(=O)C=C1CCC1C2CCC2(C)C(C/C=N/O)CCC12 CHEMBL135993 IC50 520.0 nM
Oc1ccc2ccc(-c3cccnc3)c(F)c2c1 CHEMBL2420676 IC50 523.0 nM
Clc1ccccc1-c1noc2c(-c3cncnc3-n3nccn3)cccc12 CHEMBL3696106 IC50 524.0 nM
COCCOc1noc2c(-c3cnccc3C)cccc12 CHEMBL3696107 IC50 524.0 nM
Fc1ccc(-c2cnc3c(-c4cccnc4)ccnn23)cc1 CHEMBL3916537 IC50 524.0 nM
Oc1ccc2ccc(-c3cncc(F)c3)c(Cl)c2c1 CHEMBL2420680 IC50 525.0 nM
Nc1ncncc1-c1ccnc2c1cnn2-c1ccccn1 CHEMBL5289901 IC50 525.0 nM
C/C(=N/O)C1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C CHEMBL341984 IC50 530.0 nM
O=C1N(c2cc3ccsc3cc2F)CCN1c1cnccc1C1CC1 CHEMBL3677949 IC50 548.0 nM
COc1ccc(-c2cc(Cn3ccnc3)c3ccc4[nH]ccc4c3n2)cc1 CHEMBL2442757 IC50 550.0 nM
C=C1C[C@@]2(C)C(=CC1=O)CCC1C2CC[C@@]2(C)C1CC[C@]2(C)OC(C)=O CHEMBL76877 IC50 562.0 nM
CC(C)C(O)(c1ccc2cc(OCC(F)(F)F)ccc2c1)c1c[nH]nn1 CHEMBL3264609 IC50 570.0 nM
c1cc(Cc2ccc(-c3ccsc3)cc2)ccn1 CHEMBL1214735 IC50 577.0 nM
CCCC(c1ccc(-c2ccccc2)cc1)n1ccnc1 CHEMBL449343 IC50 580.0 nM
CCC(c1ccc(-c2cscc2C)cc1)n1ccnc1 CHEMBL402971 IC50 584.0 nM
OC1(c2ccncc2)CCCc2cc(-c3ccc(F)cc3)ccc21 CHEMBL498652 IC50 587.0 nM
Fc1ccc(-c2ccc(Cc3ccncc3)cc2)cc1F CHEMBL1214660 IC50 598.0 nM
Clc1ccc(C(Cn2ccnc2)OCc2c(Cl)cccc2Cl)c(Cl)c1 CHEMBL1571863 Ki 610.0 nM
COc1ccc(Cn2ccnc2)c2c(=O)c3ccccc3oc12 CHEMBL2333329 IC50 610.0 nM
CC(=O)N1CCN(c2ccc(/C=C/c3cc(F)cc(-c4cccnc4)c3)cc2)CC1 CHEMBL4285301 IC50 610.0 nM
Cc1ccncc1-c1cccc2c(OCc3ccc4ccccc4c3)noc12 CHEMBL3696114 IC50 611.0 nM
CC(CCC(=O)OC1CC2CC=CC1C2)[C@H]1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CCC21 CHEMBL80216 IC50 616.5 nM
CC(=O)N1CCN(c2ccc(/C=C/c3cc(Cl)cc(-c4cccnc4)c3)cc2)CC1 CHEMBL4287119 IC50 620.0 nM
C[C@]12CCC3C(CC=C4C[C@@H](O)CC[C@@]43C)C1C/C(=N\O)C2 CHEMBL305941 IC50 628.0 nM
COc1ccc2ccc(-c3cncnc3)c(Cl)c2c1 CHEMBL2420685 IC50 632.0 nM
Fc1ccc(-n2ncc3c(-n4ccnc4)ccnc32)cc1 CHEMBL3962764 IC50 640.0 nM
c1csc(-c2ccc(Cc3ccncc3)cc2)c1 CHEMBL1214736 IC50 647.0 nM
Cc1ccncc1-c1cccc2c1ncn2-c1ccncn1 CHEMBL2147039 IC50 656.0 nM
CC(=O)O[C@H]1CCC2C3C=CC4=CC(=O)C=C[C@]4(C)C3CC[C@@]21C CHEMBL419831 IC50 660.25 nM
Cc1ccncc1-c1ccnn2c(-c3cc(Cl)cc(Cl)c3)cnc12 CHEMBL3981830 IC50 664.0 nM
COc1ccc2cc(-c3cccnc3)ccc2c1 CHEMBL362968 IC50 667.0 nM
C[C@@H]1CCC2C(C)(C)C3CC21CC[C@@]3(C)OC(=O)C(C)(C)c1cccnc1 CHEMBL444068 IC50 670.0 nM
Fc1ccc(-c2ccc3c(c2)CCC3n2ccnc2)cc1 CHEMBL522414 IC50 670.0 nM
Nc1ncncc1-c1cccc2c1ncn2CC(F)(F)F CHEMBL2147045 IC50 674.0 nM
N#Cc1ccc2cc(-c3cccnc3)ccc2c1 CHEMBL196796 IC50 686.0 nM
C[C@]12CCC3C(CC=C4C[C@@H](O)CC[C@@]43C)C1CCC2[C@]1(C)CO1 CHEMBL137616 IC50 720.0 nM
COc1ccc2ccc(-c3cccnc3)cc2c1 CHEMBL193863 IC50 721.0 nM
CN(C=O)C1CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@@]21C CHEMBL137507 IC50 750.0 nM
C[C@@H](C#N)C1CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@@]21C CHEMBL136967 IC50 750.0 nM
Fc1ccc(-c2ccc(C(CCCl)n3ccnc3)cc2)cc1 CHEMBL500139 IC50 756.0 nM
Cc1ccncc1-c1cccc2c1ncn2-c1ncc(F)cc1F CHEMBL2147038 IC50 758.0 nM
c1cc(Cc2ccc(-c3ccc4[nH]ccc4c3)cc2)ccn1 CHEMBL1214737 IC50 760.0 nM
c1ccc(CC(c2ccc(-c3ccccc3)cc2)n2ccnc2)cc1 CHEMBL526293 IC50 780.0 nM
CC(C)C(c1ccncc1)c1ccc(-c2cccc(O)c2)cc1 CHEMBL1172559 IC50 783.0 nM
Nc1ncncc1-c1cccc2c1ncn2-c1ccc(F)cc1F CHEMBL2147047 IC50 797.0 nM
Cc1ccncc1-c1ccnc2c1cnn2Cc1ccc(F)cc1 CHEMBL5278719 IC50 800.0 nM
c1cncc(Nc2ccc(-n3cnc4ccccc43)cc2)c1 CHEMBL5401373 IC50 830.0 nM
CC(C)=C(c1ccncc1)c1ccc(-c2ccc(NC(=O)OC(C)(C)C)c(F)c2)cc1 CHEMBL1173795 IC50 852.0 nM
CC(=O)Nc1cccc(-c2ccc(Cc3ccncc3)cc2)c1 CHEMBL1215730 IC50 876.0 nM
O=c1c2ccccc2oc2cccc(Cn3ccnc3)c12 CHEMBL1083652 IC50 880.0 nM
C/C(C#N)=C1/CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@]12C CHEMBL336025 IC50 890.0 nM
CC(c1ccc(-c2ccccc2)cc1)n1ccnc1 CHEMBL497499 IC50 910.0 nM
c1ccc(-c2cc(Cn3ccnc3)c3ccc4[nH]ccc4c3n2)cc1 CHEMBL2442756 IC50 910.0 nM
C[C@]12CCC(=O)C=C1CCC1C2CC[C@]2(C)C(n3cnc4ccccc43)=CCC12 CHEMBL77789 IC50 915.0 nM
CC(c1ccc(-c2ccsc2)cc1)n1ccnc1 CHEMBL273191 IC50 953.0 nM
COc1cc2cnc(C(O)(c3cnn[nH]3)C(C)C)cc2cc1OC CHEMBL3689756 IC50 960.0 nM
C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)C1=CC[C@@H]2[C@@H]1CN1 CHEMBL2112782 IC50 970.0 nM
CC(=O)[C@@]1(Br)CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C CHEMBL2112755 IC50 970.0 nM