COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3cccnc3)cc1)CC2 CHEMBL278267 IC50 0.0 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(-c3ccccc3)cc(-c3cccnc3)c1)CC2 CHEMBL280297 IC50 0.0 nM
O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12 CHEMBL283196 IC50 0.0 nM
c1cn(-c2ccc(Nc3nc(-c4nccs4)cs3)cc2)cn1 CHEMBL5279681 IC50 0.125 nM
CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2 CHEMBL276140 AC50 0.7943 nM
CCCC[C@H]1C(=O)N(c2ccccc2)N(c2ccc(O)cc2)C1=O CHEMBL1235001 AC50 1.0 nM
NNS(=O)(=O)c1cc(C(=O)O)cc(C(=O)O)c1 CHEMBL443954 AC50 1.0 nM
CCN1CCCC(OC(=O)C(c2ccccc2)c2ccccc2)C1 CHEMBL1623992 AC50 1.259 nM
COc1cc(/C=C/c2cccs2)cc(OCCn2ccnc2)c1 CHEMBL4447260 IC50 1.5 nM
Cn1c(N)nc2c(nc(OCc3ccccc3)n2[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)c1=O CHEMBL1079195 AC50 2.512 nM
CC(C)(C)c1nnc(-c2nn(-c3ccc(Cl)cc3Cl)c(-c3ccc(Br)cc3)c2Cn2cncn2)s1 CHEMBL1223034 IC50 2.7 nM
O=C(O)c1ccccc1-c1ccccc1C(=O)Nc1ccc2c(c1)nc(O)c1ccccc12 CHEMBL1172911 AC50 3.162 nM
Cn1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1 CHEMBL297784 AC50 3.981 nM
CCOc1ccc(NC(C)=O)cc1 CHEMBL16073 IC50 4.9 nM
O=C(O)C(Cc1ccccc1)Cc1ccccc1 CHEMBL1742271 AC50 5.012 nM
CCCS(=O)(=O)N1CCCC(C(=O)N2CCN(c3ccccc3)CC2)C1 CHEMBL1524497 AC50 5.012 nM
COc1c(-c2ccccc2)oc2c(ccc3ccoc32)c1=O CHEMBL4282750 Ki 6.0 nM
CCCS(=O)(=O)N1CCCC(C(=O)NCc2cccnc2)C1 CHEMBL1571749 AC50 6.31 nM
Cc1ccc2c(c1)N(CCC(=O)N1CCC3(CC1)OCCO3)C(=O)C(C)O2 CHEMBL1562229 AC50 6.31 nM
COc1ccccc1NC(=O)CCc1c(C)nc(O)c(C#N)c1C CHEMBL1441011 AC50 6.31 nM
CCCS(=O)(=O)N1CCCC(C(=O)NCCCN2CCN(c3cccc(Cl)c3)CC2)C1 CHEMBL1538008 AC50 6.31 nM
OCc1nnn(-c2cccc(C(F)(F)F)c2)c1CO CHEMBL1741552 AC50 6.31 nM
COc1ccc(C2N(c3ccccn3)C(=O)C3CCCN32)c(OC)c1 CHEMBL1722356 AC50 6.31 nM
Cc1csc(NC(=O)CCNS(=O)(=O)c2ccc3c(c2)c(=O)n(C)c(=O)n3C)n1 CHEMBL1419628 AC50 6.31 nM
O=C(NCCCN1CCN(c2cccc(Cl)c2)CC1)C1CCC(=O)N1Cc1ccccc1Cl CHEMBL1460951 AC50 6.31 nM
Cc1ccc(Cc2c(C)nc3nc(SCC(=O)NCc4ccco4)nn3c2C)cc1 CHEMBL1370314 AC50 6.31 nM
CCCCOc1ccc(-n2ccnc2)cc1 CHEMBL112532 IC50 7.0 nM
c1cc2ccc3cccc4ccc(c1)c2c34 CHEMBL279564 IC50 7.0 nM
O=c1oc2cc(/N=C\c3ccc4c(c3)OCO4)ccc2c2ccccc12 CHEMBL1362657 AC50 7.943 nM
Cc1ccccc1-c1cncnc1NC1CCNCC1 CHEMBL1413161 AC50 7.943 nM
CC(=O)c1ccc(NC(=O)C2CC(c3ccc(F)cc3)=NO2)cc1 CHEMBL1520998 AC50 7.943 nM
NCc1noc(-c2nn(Cc3ccccc3)c3ccccc23)n1 CHEMBL512079 IC50 9.0 nM
Oc1cccc(-c2ccc3c(-c4cccnc4)c(O)ccc3c2)c1 CHEMBL1650645 IC50 10.0 nM
CN1CCCC[C@@H]1CCN1CCCCC1 CHEMBL1741836 AC50 10.0 nM
COc1ccc(N(C)S(=O)(=O)c2ccc3c(c2)CCC(=O)N3)cc1 CHEMBL1348869 AC50 10.0 nM
O=C(O)CCCCCNC(=O)c1ccncc1 CHEMBL1709113 AC50 10.0 nM
CCCN(CCC)CCCNC(=O)c1ccc2c(c1)N(CC)C(=O)c1ccccc1[S+]2[O-] CHEMBL1329194 AC50 10.0 nM
CC(=O)NC(Cc1ccc(F)cc1)C(=O)O CHEMBL1734583 AC50 10.0 nM
O=C(CCNC(=O)Cn1cnc2ccccc2c1=O)NCC1COc2ccccc2O1 CHEMBL1310885 AC50 10.0 nM
O=c1cc(-c2ccc(Cl)cc2)oc2c1ccc1ccccc12 CHEMBL425868 IC50 10.6 nM
COc1cccc2c(=O)n3c(nc12)-c1[nH]c2ccccc2c1CC3 CHEMBL314132 IC50 11.0 nM
COc1cc(/C=C/c2cccs2)cc(OC)c1 CHEMBL42428 IC50 11.0 nM
COc1cc(/C=C\c2cccs2)cc(OC)c1 CHEMBL122532 IC50 11.0 nM
O=c1cc(-c2ccc(F)cc2)oc2c1ccc1ccccc12 CHEMBL359819 IC50 12.1 nM
Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21 CHEMBL85194 AC50 12.59 nM
Cn1c(=O)c2nc(SCc3ccccn3)[nH]c2n(C)c1=S CHEMBL1437436 AC50 12.59 nM
O=C(O)CSc1ccccc1C(=O)O CHEMBL1409646 AC50 12.59 nM
CC#Cc1ccc(-c2ccccc2)cc1 CHEMBL1743360 KI 13.0 nM
COc1ccccc1-c1cc(=O)c2cc(OC)c3c(OC)ccc(OC)c3c2o1 CHEMBL3422339 IC50 13.5 nM
Fc1cccc(Nc2nc(-c3nc(-c4cccnc4)cs3)cs2)c1 CHEMBL5287897 IC50 13.55 nM
O=c1cc(-c2ccccc2)oc2c3c(cc(O)c12)OCC=C3 CHEMBL2347912 IC50 14.0 nM
O=C(O)CCC(=O)Nc1ccc(-c2c(O)ccc3cc(-c4cccc(O)c4)ccc23)cc1 CHEMBL3645217 IC50 14.0 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccc(F)cc3)oc12 CHEMBL3422335 IC50 15.4 nM
CN(C)CCn1c(C(=O)O)cc2ccccc21 CHEMBL1492220 AC50 15.85 nM
COc1ccc(CCCO[C@@H](Cn2ccnc2)c2ccc(OC)cc2)cc1 CHEMBL1394302 AC50 15.85 nM
COc1c2occc2cc2ccc(=O)oc12 CHEMBL416 AC50 15.85 nM
COCCCC/C(=N/OCCN)c1ccc(C(F)(F)F)cc1 CHEMBL1314286 AC50 15.85 nM
CC1=C(C(=O)N2CCCCCC2)C2(CCC(C)CC2)OC1=O CHEMBL1741773 AC50 15.85 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 AC50 15.85 nM
O=c1[nH]c2ccccc2c2ccccc12 CHEMBL45245 IC50 16.0 nM
CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2 CHEMBL311469 IC50 16.0 nM
c1ccc2c(c1)Nc1ccccc1S2 CHEMBL828 IC50 16.0 nM
Cn1c(=O)cc2c3c(c(N)ccc31)C(=O)c1ccccc1-2 CHEMBL603095 IC50 16.0 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccccc3)oc12 CHEMBL3422257 IC50 16.1 nM
COc1ccc(-c2cc(=O)c3cc(OC)c4c(OC)ccc(OC)c4c3o2)cc1 CHEMBL3422340 IC50 16.4 nM
O=c1cc(-c2ccccc2F)oc2c1ccc1ccccc12 CHEMBL361608 IC50 18.0 nM
COc1ccc(-c2cc(=O)c3cc(OC)c4c(OC)ccc(OC)c4c3o2)cc1OC CHEMBL3422341 IC50 19.3 nM
O=[N+]([O-])c1cc(Cl)cc2c1nc(NCCO)c1ccccc12 CHEMBL1406307 AC50 19.95 nM
O=c1cc(-c2ccccc2)oc2cc(O)cc(O)c12 CHEMBL117 AC50 19.95 nM
Cc1c2ccncc2c(C)c2c1[nH]c1ccccc12 CHEMBL123 AC50 19.95 nM
c1ccc2c(c1)[I+]c1ccccc1-2 CHEMBL365739 AC50 19.95 nM
COc1ccc(CCCOc2cc(CCn3ccnc3)ccc2OC)cc1 CHEMBL1332270 AC50 19.95 nM
COc1c2occc2c(OC)c2c(=O)cc(C)oc12 CHEMBL44746 AC50 19.95 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2 CHEMBL14352 IC50 20.0 nM
COc1cccc(/C=C/C(=O)c2ccncc2)c1 CHEMBL4212722 IC50 20.0 nM
O=C(Nc1ccncc1)c1cc(C(F)(F)F)nc(-n2ccnc2)n1 CHEMBL5414411 IC50 20.0 nM
O=[N+]([O-])c1ccc2nc3c(nc2c1)-c1cccc2cccc-3c12 CHEMBL3217889 pIC50 20.89 nM
Brc1ccc2c3c(cccc13)-c1nc3ccccc3nc1-2 CHEMBL3217888 pIC50 21.88 nM
O=c1c2ccccc2nc2n1CCc1c-2[nH]c2ccccc12 CHEMBL85139 IC50 22.0 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccccc3F)oc12 CHEMBL3422258 IC50 22.1 nM
O=c1cc(-c2cccnc2)oc2c1ccc1ccccc12 CHEMBL177938 IC50 23.2 nM
COc1cc(-c2cc(=O)c3cc(OC)c4c(OC)ccc(OC)c4c3o2)cc(OC)c1OC CHEMBL3422342 IC50 23.5 nM
O=c1cc(-c2ccccn2)oc2c1ccc1ccccc12 CHEMBL4466261 IC50 25.1 nM
CC#CCOC(=O)c1c(C)nc2sc3c(c2c1N)CC[C@@H](O)C3 CHEMBL1318470 AC50 25.12 nM
O=C(c1cnc(N2CCN(c3ncccn3)CC2)c2ccccc12)N1CCN(c2ccccn2)CC1 CHEMBL1341400 AC50 25.12 nM
c1cn(-c2ccnc(-c3ccc4c(c3)OCO4)n2)cn1 CHEMBL1355408 AC50 25.12 nM
COc1ccc(N(CC(=O)O)N=O)cc1 CHEMBL1318137 AC50 25.12 nM
C[C@@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@H]5S[C@H]5C[C@]43C)[C@H]1CC[C@H]2O CHEMBL1357770 AC50 25.12 nM
O=C(c1cc(-c2ccco2)on1)N1CCOCC1 CHEMBL1588100 AC50 25.12 nM
Cn1c(=O)c(-c2ccc(Cl)cc2)nc2cncnc21 CHEMBL1364995 AC50 25.12 nM
O=C(O)c1cc2cc(Cl)ccc2oc1=O CHEMBL1414071 AC50 25.12 nM
OCCN[C@@H]1c2cc(Cl)ccc2-c2c(Cl)cc(Cl)cc21 CHEMBL1742359 AC50 25.12 nM
C=CCSc1nc2ccccc2c(=O)n1Cc1ccco1 CHEMBL1328536 AC50 25.12 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)c(O)c(-c3cccc(F)c3)oc12 CHEMBL3422349 IC50 26.5 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccc(Cl)cc3)oc12 CHEMBL3422338 IC50 27.7 nM
COc1cc(/C=C/C(=O)c2ccncc2)cc(OC)c1 CHEMBL4214111 IC50 28.0 nM
O=C(/C=C/c1cccc2ccccc12)c1ccncc1 CHEMBL1568243 IC50 28.0 nM
COc1c2ccoc2c(OC)c2oc(=O)ccc12 CHEMBL140796 Ki 28.0 nM
Cc1ccncc1-c1cccc2c(-c3ccccc3)noc12 CHEMBL3696099 IC50 28.0 nM
O=c1cc(-c2ccc(F)c(F)c2)oc2c1ccc1ccccc12 CHEMBL4062213 IC50 28.6 nM
O=c1c2cc(Cl)ccc2nc2n1CCc1c-2[nH]c2ccccc12 CHEMBL85106 IC50 29.0 nM
COc1ccc2c(=O)n3c(nc2c1OC)-c1[nH]c2ccccc2c1CC3 CHEMBL85740 IC50 29.0 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3cscn3)oc12 CHEMBL4781932 IC50 29.2 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)c(O)c(-c3ccccc3F)oc12 CHEMBL3422348 IC50 29.4 nM
Oc1c2ccccc2nc2c3nc4ccccc4c-3ccn12 CHEMBL413956 IC50 30.0 nM
Cc1cc2c(ccc3c(=O)cc(-c4ccccc4)oc32)o1 CHEMBL3601433 Ki 30.0 nM
C=CCO[C@@H](Cn1ccnc1)c1ccc(Cl)cc1Cl CHEMBL1359713 AC50 31.62 nM
CO/N=C1/[C@H]2O[C@@H]2[C@@H](O)[C@H]2[C@H]1CCn1c(=O)n(-c3ccccc3)c(=O)n12 CHEMBL1741632 AC50 31.62 nM
COc1cc(OC)cc(C(=O)NCC(=O)OC2CCOC2=O)c1 CHEMBL1340380 AC50 31.62 nM
CS(=O)(=O)Nc1ccc(Cc2noc(-c3ccc4[nH]cc(CCN)c4c3)n2)cc1 CHEMBL39317 AC50 31.62 nM
O=Nc1c(-c2c(O)[nH]c3ccccc23)[nH]c2ccccc12 CHEMBL126077 AC50 31.62 nM
O=C(Nc1cccc(-c2cn3cccnc3n2)c1)c1ccco1 CHEMBL1312033 AC50 31.62 nM
Cc1cccc2nc(C(F)(F)F)nc(=O)n12 CHEMBL1375008 AC50 31.62 nM
COc1cccc(-c2nccc(-n3ccnc3)n2)c1 CHEMBL405912 AC50 31.62 nM
CC(=N)/C(C#N)=C(/O)COc1ncnc2ccc(Br)cc12 CHEMBL3213457 AC50 31.62 nM
NCCCc1ccc2oc3ccccc3c2c1 CHEMBL1609160 AC50 31.62 nM
COc1ccc(OC)c(NC(=O)CC(Cc2ccccc2OC)C(=O)O)c1 CHEMBL1389564 AC50 31.62 nM
Cc1nc([N+](=O)[O-])cn1-c1nc2ccccn2c1[N+](=O)[O-] CHEMBL1372548 AC50 31.62 nM
NNC(=O)CCc1ccc2ccc3ccccc3c2c1 CHEMBL1332504 AC50 31.62 nM
Oc1c(I)cc(Cl)c2cccnc12 CHEMBL497 AC50 31.62 nM
COc1ccc(-c2csc(-c3csc(Nc4cccc(F)c4)n3)n2)cc1OC CHEMBL5277075 IC50 31.62 nM
COc1ccccc1/C=C/C(=O)c1ccncc1 CHEMBL4209004 IC50 32.0 nM
NCc1noc(-c2nn(CCc3ccccc3)c3ccccc23)n1 CHEMBL467519 IC50 34.0 nM
Cc1ccncc1-c1cccc2c(-c3ccccc3)cnn12 CHEMBL5284599 IC50 34.0 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)c(O)c(-c3ccccc3)oc12 CHEMBL3422347 IC50 34.4 nM
C=C=C[C@H]1CC[C@H](c2cc(=O)c3ccc4ccccc4c3o2)CC1 CHEMBL4579760 IC50 36.4 nM
O=c1cc(-c2ccncc2)oc2c1ccc1ccccc12 CHEMBL177991 IC50 36.4 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3cccc(F)c3)oc12 CHEMBL3421639 IC50 36.7 nM
O=c1c2ccc(Cl)cc2nc2n1CCc1c-2[nH]c2ccccc12 CHEMBL86078 IC50 39.0 nM
CCCCCCCCCOc1ccc2[nH]cc(CCN)c2c1 CHEMBL97450 AC50 39.81 nM
CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@H]3[C@H]2CC(=O)[C@]2(C)[C@@H]3C[C@@H](N3CC3)[C@H]2C(C)=O)C1 CHEMBL1528540 AC50 39.81 nM
Cn1c(=O)c2cc(S(=O)(=O)NCCC(=O)NCCc3ccc(Cl)cc3)ccc2n(C)c1=O CHEMBL1565258 AC50 39.81 nM
Cc1noc(C)c1-c1nc(N(C)C)c2ccccc2n1 CHEMBL1496596 AC50 39.81 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] CHEMBL193 AC50 39.81 nM
CN1CCN(c2nc3cc(C(F)(F)F)ccc3n3cccc23)CC1 CHEMBL27403 AC50 39.81 nM
c1ccc(-c2nc(NCCCn3ccnc3)c3oc4ccccc4c3n2)cc1 CHEMBL1594359 AC50 39.81 nM
COc1ccc(C)cc1NC(=O)CN1CCN(S(=O)(=O)c2ccc(F)cc2)CC1 CHEMBL1413982 AC50 39.81 nM
Cc1c(NC(C)C)c(=O)n(-c2ccccc2)n1C CHEMBL157337 AC50 39.81 nM
N#Cc1cccc(-c2cc(NCc3cccnc3)ncn2)c1 CHEMBL1563497 AC50 39.81 nM
COc1ccc(CCNc2c(C)c(C)nc3ncnn23)cc1 CHEMBL1499501 AC50 39.81 nM
O=C(O)c1oc(C(=O)O)c(C(=O)O)c1C(=O)O CHEMBL1742368 AC50 39.81 nM
O=c1c(O)c(-c2ccccc2)oc2cc(O)cc(O)c12 CHEMBL309490 IC50 40.0 nM
c1ccc2c(c1)cc1ccc3cccc4ccc2c1c34 CHEMBL31184 IC50 40.0 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3cccs3)oc12 CHEMBL4746097 IC50 40.4 nM
COc1cc(OC)c2nc3n(c(=O)c2c1)CCc1c-3[nH]c2ccccc12 CHEMBL314445 IC50 41.0 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)c(O)c(-c3cccc(Cl)c3)oc12 CHEMBL3422352 IC50 42.5 nM
Fc1ccc(-c2cc(=S)c3ccc4ccccc4c3o2)cc1 CHEMBL4465703 IC50 42.8 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccc(OCc4ccccc4)cc3)oc12 CHEMBL3422343 IC50 43.0 nM
Cc1cc2c(cc(O)c3c(=O)cc(-c4ccccc4)oc32)o1 CHEMBL3601434 Ki 44.0 nM
COc1ccc(Br)cc1C(=O)Nc1ccc(Cc2ccncc2)cc1 CHEMBL1374962 AC50 44.67 nM
O=C(N/N=C/C=C/c1ccccc1)c1cc2c(ccc3ccccc32)o1 CHEMBL3197136 AC50 44.67 nM
O=S(=O)(Nc1ccc(Cc2ccncc2)cc1)c1ccc(Br)cc1 CHEMBL1299525 AC50 44.67 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccc(-c4c[nH]nn4)cc3)oc12 CHEMBL4748722 IC50 47.8 nM
C(=N/n1cnnc1)\c1ccc(-c2cccc3ccccc23)o1 CHEMBL3217886 pIC50 47.86 nM
c1cn(Cc2ccc(Nc3nc(-c4nccs4)cs3)cc2)cn1 CHEMBL5280415 IC50 48.55 nM
CN1C(=O)/C(=C2\NC(=S)NC2=O)c2cc(Br)ccc21 CHEMBL3217887 pIC50 48.98 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)c(O)c(-c3ccccc3Cl)oc12 CHEMBL3422351 IC50 49.6 nM
O=C1Nc2ccccc2/C1=C/c1ccc2cn[nH]c2c1 CHEMBL3353337 IC50 50.0 nM
C[C@@H](N)Cn1ccc2cc(F)c(Cl)cc21 CHEMBL574985 AC50 50.12 nM
O=C(O)c1ccc(CSc2nc3ccccc3o2)cc1 CHEMBL1468227 AC50 50.12 nM
CNC(=O)c1cc2c3ccccc3nc-2c[nH]1 CHEMBL429711 AC50 50.12 nM
COC(=O)c1c(C)n(-c2ccccc2)c2ccc(O)cc12 CHEMBL1519576 AC50 50.12 nM
CNc1nc(-c2c(C)noc2C)nc2ccccc12 CHEMBL1443323 AC50 50.12 nM
CCOCC(=O)Nc1cc(-c2cn3cccnc3n2)ccc1C CHEMBL1504991 AC50 50.12 nM
Cn1cnnc1SCC(=O)n1c2ccccc2c2ccccc21 CHEMBL1607206 AC50 50.12 nM
Fc1cc2c3[nH]ncc3n(-c3cccnc3)c2cc1F CHEMBL3798844 pIC50 50.12 nM
COc1ccc(-c2cc(C(F)(F)F)cc3[nH]ncc23)c(OC)n1 CHEMBL3797286 pIC50 50.12 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccccc3O)oc12 CHEMBL3422346 IC50 50.6 nM
Fc1ccccc1-c1cc(=S)c2ccc3ccccc3c2o1 CHEMBL4562047 IC50 51.8 nM
Cc1cc(Br)cc2[nH]c(-c3c(N[C@H](CO)Cc4ccccc4)cc[nH]c3=O)nc12 CHEMBL397667 IC50 52.0 nM
S=c1cc(-c2ccc(Cl)cc2)oc2c1ccc1ccccc12 CHEMBL4474545 IC50 53.2 nM
Clc1cc(Cl)cc(Nc2nc(-c3nccs3)cs2)c1 CHEMBL5280516 IC50 55.7 nM
CC/C(=C(/c1ccc(O)cc1)c1ccc(OCCN)cc1)c1ccc(O)cc1 CHEMBL3422028 Ki 56.0 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)c(OCCOC(=O)CN)c(-c3cccc(F)c3)oc12 CHEMBL3422354 IC50 56.2 nM
c1ccc2c(c1)oc1c(NCCCn3ccnc3)ncnc12 CHEMBL1402633 AC50 56.23 nM
N#Cc1c(-c2ccc3c(c2)OCO3)ccn2nc(-c3cccc(C(F)(F)F)c3)nc12 CHEMBL1504600 AC50 56.23 nM
COc1ccc(C=O)cc1COc1c(Cl)cc(Cl)cc1Cl CHEMBL3217884 pIC50 56.23 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)c(O)c(-c3ccc(F)cc3)oc12 CHEMBL3422350 IC50 57.6 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccccc3Cl)oc12 CHEMBL3422336 IC50 58.0 nM
O=c1cc(-c2ccccc2)oc2c3c(ccc12)OCC=C3 CHEMBL2347756 Ki 58.0 nM
Cn1cncc1-c1ccnc2c1cnn2-c1ccc(F)cc1 CHEMBL3902750 IC50 58.0 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccc(O)cc3)oc12 CHEMBL3422345 IC50 58.4 nM
CC#Cc1ccc2c(ccc3ccccc32)c1 CHEMBL253346 IC50 60.0 nM
CN(C)S(=O)(=O)N1CC[C@@H](Oc2cc(F)cc(NC(=O)Nc3cccnc3)c2)C1 CHEMBL1800951 IC50 60.0 nM
COc1c2ccoc2cc2oc(=O)ccc12 CHEMBL24171 Ki 60.0 nM
C=CC(=O)N1CCC(Cn2cc(-c3ccc4c(c3)OCO4)c3c(N)ncnc32)CC1 CHEMBL4755698 IC50 60.0 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3cccc(Cl)c3)oc12 CHEMBL3422337 IC50 61.1 nM
Cc1cc(C)cc(Cn2nc(-c3nc(CN)no3)c3ccccc32)c1 CHEMBL448430 IC50 62.0 nM
O=c1cc(-c2cccc(F)c2)oc2c1ccc1ccccc12 CHEMBL436080 IC50 62.2 nM
C[C@H]1CC[C@@H]2[C@@H](C)C(=O)O[C@H]3O[C@@]4(C)CC[C@H]1[C@@]32OO4 CHEMBL1401626 AC50 63.1 nM
Cl/C(=C\n1cncn1)c1ccc(Cl)cc1Cl CHEMBL1397886 AC50 63.1 nM
CCOC(=O)c1c(C)oc2c1cc(O)c1ccccc12 CHEMBL1447964 AC50 63.1 nM
COC(=O)c1[nH]c2ccc(Br)cc2c1NC(=O)Oc1ccccc1 CHEMBL1506130 AC50 63.1 nM
Cc1sc(N/N=C/c2cccnc2)nc1-c1ccccc1 CHEMBL1984764 AC50 63.1 nM
CCOc1ccc(C(C)=O)cc1N1C(=O)C2C3C=CC(C3=C(C)C)C2C1=O CHEMBL1524598 AC50 63.1 nM
O=C(O)C[S+]([O-])c1ccc2c3c(cccc13)C(=O)c1ccccc1-2 CHEMBL1162521 AC50 63.1 nM
Cc1noc(C)c1-c1nc(N(C)Cc2ccco2)c2ccccc2n1 CHEMBL1404408 AC50 63.1 nM
O=c1cc(-c2ccc(O)cc2)oc2cc(O)cc(O)c12 CHEMBL28 AC50 63.1 nM
c1cc2c3c(c1)c1c(n3CCNC2)CCCC1 CHEMBL258465 AC50 63.1 nM
CCCCNc1c(C(=O)OCC)c(C)nc2c1cnn2CC CHEMBL84567 AC50 63.1 nM
O=C(O)CCC(=O)Nc1ccc2ccccc2c1 CHEMBL1741330 AC50 63.1 nM
COc1ccc(C2C(C(=O)N3CCOCC3)CCC(=O)N2c2ccc(OC)cc2)cc1 CHEMBL1422722 AC50 63.1 nM
Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 CHEMBL960 AC50 63.1 nM
CCOc1ccc(-c2cc(CCCC(=O)NCCc3ccc(OC)c(OC)c3OC)no2)cc1 CHEMBL1470566 AC50 63.1 nM
Cc1cccc(C(=O)O)c1C[C@H]1NCC[C@H]2c3ccccc3N[C@@H]12 CHEMBL1438786 AC50 63.1 nM
Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12 CHEMBL16687 AC50 63.1 nM
COc1ccc(OC)c2c(=S)c3ccccc3[nH]c12 CHEMBL1331734 AC50 63.1 nM
CN(CCC(=O)O)C1=Nc2ccc(Cl)cc2C(c2ccccc2)=[N+]([O-])C1 CHEMBL1331754 AC50 63.1 nM
COc1ccc(-c2cc(=O)c3c(O)cc(O)cc3o2)cc1 CHEMBL243664 AC50 63.1 nM
N#Cc1ccccc1-c1cncnc1NCc1cccnc1 CHEMBL1556045 AC50 63.1 nM
O=C(Nc1cccnc1)c1ccc2snnc2c1 CHEMBL1516856 AC50 63.1 nM
N#Cc1cccc(-c2ccc3ncnc(NCc4cccnc4)c3c2)c1 CHEMBL1554721 AC50 63.1 nM
Cc1c2ccccc2c(CSC(=N)N)c2ccccc12 CHEMBL1409073 AC50 63.1 nM
COc1ccc(C(=O)c2ccccc2O)c(O)c1 CHEMBL1326877 AC50 63.1 nM
O=C1CN(C(=O)c2ccc(Br)o2)C(c2ccc(F)cc2)c2cc(Cl)ccc2N1 CHEMBL1596063 AC50 63.1 nM
N#C/C(=C(/O)Oc1ccccc1)c1nc2ccccc2c2ccccc12 CHEMBL1388203 AC50 63.1 nM
Clc1ccc2c3[nH]ncc3n(-c3cccnc3)c2c1 CHEMBL3798249 pIC50 63.1 nM
CONC(=O)c1cc(Nc2ncnn3cc(-c4ncc(C)o4)c(C(C)C)c23)c(F)cc1F CHEMBL193306 IC50 64.0 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccco3)oc12 CHEMBL4744690 IC50 67.2 nM
COc1ccc(-c2nc(-c3cccnc3)cs2)c(OC)c1 CHEMBL5406710 IC50 68.0 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)c(OCCOC(=O)[C@@H](N)C(C)C)c(-c3cccc(F)c3)oc12 CHEMBL3422356 IC50 68.3 nM
Cc1ccncc1-c1cccc2c1cnn2-c1cscn1 CHEMBL3780048 IC50 70.0 nM
O=C(Nc1ccc(-c2csc(-c3ccccc3)n2)cc1)c1ccccc1Cl CHEMBL1580265 AC50 70.79 nM
NC(S)=Nc1cc2ccccc2c2ccccc12 CHEMBL1454711 AC50 70.79 nM
O=c1c2ccccc2c(-c2ccccc2)nn1Cc1ccc(Cl)cc1 CHEMBL1401960 AC50 70.79 nM
C#CCOc1cccc(-c2cc(=O)c3c(O)cccc3o2)c1 CHEMBL2347914 Ki 71.0 nM
COc1ccc(Nc2nc(-c3cccs3)cs2)cc1 CHEMBL1412492 IC50 72.0 nM
O=c1cc(-c2cccc(Cl)c2)oc2c1ccc1ccccc12 CHEMBL368236 IC50 73.6 nM
O/N=c1\cc(-c2ccccc2)oc2c1ccc1ccccc12 CHEMBL4434863 IC50 74.6 nM
[N-]=[N+]=Nc1cccc(-c2cc(=O)c3ccc4ccccc4c3o2)c1 CHEMBL4514232 IC50 74.7 nM
Cc1ccncc1-c1cccc2c1ncn2-c1nccs1 CHEMBL3781487 IC50 75.0 nM
O/N=c1\cc(-c2ccc(Cl)cc2)oc2c1ccc1ccccc12 CHEMBL4466582 IC50 75.2 nM
COc1ccc2c(=O)n3c(nc2c1)-c1[nH]c2ccccc2c1CC3 CHEMBL312248 IC50 76.0 nM
CC/C(=C(/c1ccc(O)cc1)c1ccc(OCCN)cc1)c1ccccc1 CHEMBL2386285 Ki 76.0 nM
O=c1cc(-c2ccccc2)oc2c1ccc1ncccc12 CHEMBL3601435 Ki 76.0 nM
c1csc(-c2csc(Nc3ccc4c(c3)OCO4)n2)n1 CHEMBL5278329 IC50 78.46 nM
CCCCCc1cc(O)c2c(c1)OC(C)(C)c1ccc(C)cc1-2 CHEMBL74415 Ki 79.0 nM
O=C(c1c[nH]c(=O)n(-c2ccccc2)c1=O)N1CCc2ccccc21 CHEMBL1367499 AC50 79.43 nM
COc1ccc2[nH]cc(CCNc3ncnc4ccc(-c5cccnc5)cc34)c2c1 CHEMBL1438323 AC50 79.43 nM
CN(C)c1ncc2nc(-c3cc(F)cc(F)c3)c(=O)n(C[C@H]3CCCO3)c2n1 CHEMBL1355185 AC50 79.43 nM
CS(=O)(=O)Nc1cccc(-c2ccc3ncnc(NCc4cccs4)c3c2)c1 CHEMBL1314222 AC50 79.43 nM
Clc1ccccc1-c1nc(-c2ccncc2)no1 CHEMBL1402420 AC50 79.43 nM
O=C(O)CSc1nnc2c3ccccc3c3ccccc3c2n1 CHEMBL1366085 AC50 79.43 nM
Cc1ccccc1-c1nccc(-n2ccnc2)n1 CHEMBL1415521 AC50 79.43 nM
CCCCOC(=O)c1ccc(O)cc1 CHEMBL459008 AC50 79.43 nM
O=C(c1c(O)nc2cc(Cl)ccc2c1O)C1CC1 CHEMBL115225 AC50 79.43 nM
c1cncc(CNc2ncnc3ccc(-c4cccnc4)cc23)c1 CHEMBL1355644 AC50 79.43 nM
COc1ccc2c(OC)c3ccoc3nc2c1OC CHEMBL21396 AC50 79.43 nM
Cc1c2cnccc2c(C)c2c1c1ccccc1n2CCOC(=O)c1ccccc1 CHEMBL1374334 AC50 79.43 nM
CCCn1c(=O)c2nc(-c3ccccc3)[nH]c2n(CCC)c1=O CHEMBL158507 AC50 79.43 nM
c1ccc(Nc2ncnc3ccc(-c4cccnc4)cc23)cc1 CHEMBL1373004 AC50 79.43 nM
O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12 CHEMBL150 AC50 79.43 nM
COc1ccc(S(=O)(=O)N2CCN(CC(=O)Nc3cccc(F)c3)CC2)cc1 CHEMBL1509329 AC50 79.43 nM
Cc1nnc2ccc(-c3cccc(C(F)(F)F)c3)nn12 CHEMBL13662 AC50 79.43 nM
CNc1nc(-c2cccc(C#N)c2)nc2ccccc12 CHEMBL1551919 AC50 79.43 nM
CN1CCc2cc(NC(=O)Nc3cccnc3)ccc21 CHEMBL1456087 AC50 79.43 nM
Cc1cccc(NC(=O)C2CCN(S(=O)(=O)c3cccc4nsnc34)CC2)n1 CHEMBL1470084 AC50 79.43 nM
CCCCc1cc2ccccc2c(OCCN(C)C)n1 CHEMBL127643 AC50 79.43 nM
CC(=O)N1CCC[C@@H](Oc2cc(F)cc(NC(=O)Nc3cccnc3)c2)C1 CHEMBL1800931 IC50 80.0 nM
Cc1ccncc1-c1cccc2c1cnn2-c1nccs1 CHEMBL3780266 IC50 80.0 nM
COc1cncc(-c2ccc3cc(OC)ccc3c2)c1 CHEMBL447591 IC50 83.0 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)c(O)c(-c3ccc(Cl)cc3)oc12 CHEMBL3422353 IC50 83.3 nM
O=c1cc(-c2ccccc2)oc2ccc3ccccc3c12 CHEMBL26260 IC50 83.5 nM
Cc1cccc(Cn2nc(-c3nc(CN)no3)c3ccccc32)c1 CHEMBL466917 IC50 84.0 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)c(OCCOC(=O)[C@H](C)N)c(-c3cccc(F)c3)oc12 CHEMBL3422355 IC50 85.9 nM
COc1cc(Nc2nc(-c3nccs3)cs2)cc(OC)c1 CHEMBL5290149 IC50 88.96 nM
C#CCOc1cc(O)c2c(=O)cc(-c3ccccc3)oc2c1 CHEMBL2347911 IC50 89.0 nM
COc1cccc2cc3c(=O)oc4ccccc4c3nc12 CHEMBL1524629 AC50 89.13 nM
O=c1cc(-c2ccccc2)oc2c3c(ccc12)OCO3 CHEMBL3601436 Ki 90.0 nM
O=c1cc(-c2cccc(O)c2)oc2c1ccc1ccccc12 CHEMBL1801014 IC50 91.5 nM
Fc1cccc(Nc2nc(-c3nc(-c4ccncc4)cs3)cs2)c1 CHEMBL5287228 IC50 91.79 nM
[N-]=[N+]=Nc1ccc(-c2cc(=O)c3ccc4ccccc4c3o2)cc1 CHEMBL4474660 IC50 93.8 nM
Cc1ccncc1-c1cccc2c1ncn2-c1ccccn1 CHEMBL2147034 IC50 94.0 nM
O=c1cc(-c2cccc(C(F)(F)F)c2)oc2c1ccc1ccccc12 CHEMBL4064195 IC50 94.2 nM
COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccc(OCc4ccccc4)c(OCc4ccccc4)c3)oc12 CHEMBL3422344 IC50 96.9 nM
COc1ccc(-c2cc(=O)c3ccc4ccccc4c3o2)cc1 CHEMBL2420082 IC50 98.2 nM