CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4ccccc4n3)cc12 CHEMBL16596 IC50 0.5 nM
C[C@H](NC(=O)C(C)(C)Oc1ccc(C(F)(F)F)cn1)[C@@H](Cc1ccc(Cl)cc1)c1cccc(C#N)c1 CHEMBL220360 IC50 0.93 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccccn3)cc12 CHEMBL38958 IC50 1.0 nM
CS(=O)(=O)N(CCN1CCOCC1)c1ccc(Nc2ncc3cnn(C4CCCCCC4)c3n2)cc1 CHEMBL1825089 IC50 1.0 nM
O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12 CHEMBL150 AC50 1.259 nM
Cc1ccc(COc2ccc3c(c2)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n3Cc2ccc(-c3ccc(F)cn3)cc2)nc1 CHEMBL1922663 IC50 1.5 nM
CCCCCCCCCC(=O)N[C@@H](CN1CCOCC1)[C@@H](O)c1ccccc1 CHEMBL1337541 AC50 1.585 nM
COc1ccc2c(c1OC)C(=O)O[C@H]2[C@H]1c2cc3c(cc2CCN1C)OCO3 CHEMBL475536 AC50 1.585 nM
CCOC(=O)OCC1OC(C#Cc2ccc(C(C)(C)C)cc2)C=CC1OC(=O)OCC CHEMBL1513508 Potency 2.5 nM
O=C(O)c1cscc1Cc1cccs1 CHEMBL1568083 Potency 2.5 nM
COc1ccc2c3c([nH]c2c1)[C@@H]1C[C@@H]2[C@@H](C[C@H](O)[C@H](OC)[C@H]2C(=O)O)CN1CC3 CHEMBL1513940 Potency 2.5 nM
C[C@@H]1CCC[C@H](C)N1 CHEMBL1517793 Potency 2.5 nM
CC(C)(C)c1nnc(-c2nn(-c3ccc(Cl)cc3Cl)c(-c3ccc(Br)cc3)c2Cn2cncn2)s1 CHEMBL1223034 IC50 2.6 nM
O=C(NC1CCC(=Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1)c1cccnc1 CHEMBL4593464 IC50 2.7 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(-c3ccncc3)cc2C2=CCCCC2)n1 CHEMBL1172346 IC50 3.0 nM
CC(=O)N(C[C@@H](C)C(=O)O)c1c(I)cc(I)c(N)c1I CHEMBL1355040 Potency 3.2 nM
Nc1ccc(C(=O)NC2CCC(=Cc3cccc(Oc4ccc(C(F)(F)F)cn4)c3)CC2)cn1 CHEMBL4557596 IC50 3.4 nM
CN1[C@@H]2CC[C@H]1CC(OC(=O)[C@@H](O)c1ccccc1)C2 CHEMBL1452657 Potency 4.0 nM
COc1ccc2c(Cc3c4ccccc4cc4ccccc34)cncc2c1O CHEMBL1411360 Potency 4.0 nM
CCCc1oc2ccccc2c(=O)c1C(=O)c1cc(I)c(O)c(I)c1 CHEMBL456432 Ki 4.2 nM
COc1cnc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccc(C)cn5)ccc43)cc2)nc1 CHEMBL1229205 IC50 4.5 nM
Cc1ccnc(NS(=O)(=O)c2ccc(N)cc2)n1 CHEMBL438 Potency 5.0 nM
Cc1noc(C)c1-c1cc(NCc2cccnc2)ncn1 CHEMBL1329823 Potency 5.0 nM
COc1ccccc1CNc1cc(-c2ccccc2OC)ncn1 CHEMBL1551557 Potency 5.0 nM
CCCCCCCCN[C@@H](C)[C@H](O)c1ccc(SC(C)C)cc1 CHEMBL1520837 Potency 5.0 nM
C[C@@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@H]5S[C@H]5C[C@]43C)[C@H]1CC[C@H]2O CHEMBL1357770 Potency 5.0 nM
COC(Cc1nnc(S)n1-c1ccc(Cl)cc1)OC CHEMBL1595491 AC50 5.012 nM
Cc1c(C(=O)NN2CCCCC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1 CHEMBL111 IC50 5.3 nM
Cc1ccc2c(c1)N(CCC(=O)NCc1ccc3c(c1)OCO3)C(=O)CO2 CHEMBL1331572 AC50 5.623 nM
CCOC(=O)CC1C(=O)NCCN1S(=O)(=O)c1ccccc1Cl CHEMBL1717461 AC50 5.623 nM
C=CCOc1c(Br)cc(CNc2ccc(NC(=O)C(C)C)c(OC)c2)cc1OC CHEMBL1413367 AC50 5.623 nM
Cc1c(C(c2cccc([N+](=O)[O-])c2O)c2c(C)n(C)n(-c3ccccc3)c2=O)c(=O)n(-c2ccccc2)n1C CHEMBL1331020 AC50 5.623 nM
O=C(NNC(=O)c1ccccc1)C(=O)N1CCCCC1 CHEMBL1703998 AC50 5.623 nM
COCCCn1c(=S)[nH]c2ncccc2c1=O CHEMBL1487316 AC50 5.623 nM
CCOC(=O)Cn1c(=O)oc2cc(S(=O)(=O)NCCc3ccc(OCC)c(OCC)c3)ccc21 CHEMBL1401073 AC50 5.623 nM
COc1cc2c(cc1OC)C(C(=O)Nc1cccc(C)n1)C(c1cccnc1)N(C)C2=O CHEMBL1571970 AC50 5.623 nM
CCOC(=O)c1c(NC(=O)CCC(=O)N2CCOCC2)sc2c1CC(C)(C)OC2 CHEMBL1440921 AC50 5.623 nM
O=C(O)c1cc2cc(Cl)ccc2oc1=O CHEMBL1414071 AC50 5.623 nM
O=C1CN=C(Nc2ccc(Cl)cc2)N1c1ccccc1 CHEMBL1419308 AC50 5.623 nM
O=C(N/N=C/c1ccc(Sc2nc3ccccc3s2)c([N+](=O)[O-])c1)c1ccccn1 CHEMBL3198484 AC50 5.623 nM
CCc1nnc(SCc2ccc(OC(C)C)cc2)n1N CHEMBL1710203 AC50 5.623 nM
COc1ccc(N2CCN(C(S)=Nc3cccc(C)c3)CC2)cc1 CHEMBL1531213 AC50 5.623 nM
Cn1cnnc1SCC(=O)n1c2ccccc2c2ccccc21 CHEMBL1607206 AC50 5.623 nM
COc1ccc(CCNC(=O)COC(=O)c2cnc(C)cn2)cc1 CHEMBL1736619 AC50 5.623 nM
CCCn1nnc(NC(=O)Cc2ccccc2)n1 CHEMBL1489765 AC50 5.623 nM
O=[N+]([O-])c1ccc(/C=N/Nc2cc(Cl)nc(-c3ccccc3)n2)cc1 CHEMBL3208532 AC50 5.623 nM
Cc1ccc(OCC(O)CNC(=O)c2ccccc2C(=O)O)cc1 CHEMBL1723585 AC50 5.623 nM
O=C(Cn1nnc2ccccc21)N1CCCCC1 CHEMBL1487537 AC50 5.623 nM
COc1ccc2nc(/N=C\N(C)C)sc2c1 CHEMBL3208765 AC50 5.623 nM
Cc1ccc2c(c1)[C@@H]1CN(C)CC[C@@H]1N2S(=O)(=O)c1ccc(F)cc1 CHEMBL1502064 AC50 5.623 nM
Cc1ccc(C(=O)N(CN2CCCC2=O)c2ccccc2)cc1C CHEMBL1427932 AC50 5.623 nM
CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2 CHEMBL276140 Potency 6.3 nM
CC(=O)C1=C(O)C=C2Oc3c(C(C)=O)c(O)c(C)c(O)c3[C@]2(C)C1=O CHEMBL461903 Potency 6.3 nM
Nc1ncc(C(=O)NC2CCC(=Cc3cccc(Oc4ccc(C(F)(F)F)cn4)c3)CC2)cn1 CHEMBL4438972 IC50 6.5 nM
Cc1cccc(NC(S)=NNC(=O)CC(C)O)c1C CHEMBL1602560 AC50 7.079 nM
COc1cc2c(cc1OC)C(C(=O)NCc1cccnc1)C(c1cccnc1)N(C)C2=O CHEMBL1448158 AC50 7.079 nM
O[C@H]1CC[C@H](Nc2nccc(-n3nnc4ccccc43)n2)CC1 CHEMBL2425654 IC50 7.8 nM
CN(C)Cc1ccccc1-c1cc(NC2CC2)ncn1 CHEMBL1611893 Potency 7.9 nM
CN(C)c1cccc(OC2C=CC(C#Cc3ccccc3)OC2CO)c1 CHEMBL1395839 Potency 7.9 nM
CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1 CHEMBL633 Potency 7.9 nM
CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 CHEMBL388590 Potency 7.9 nM
C[C@@H](Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1 CHEMBL1592316 Potency 7.9 nM
CC(C)(CO)Cc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1 CHEMBL1256697 Potency 7.9 nM
CCCC[n+]1[cH-]/c(=N\C(=O)OC)on1 CHEMBL3211303 AC50 7.943 nM
CCc1nc(N[C@H](C(=O)O)C(C)CC)c2oc3ccccc3c2n1 CHEMBL1478965 AC50 8.913 nM
Cc1ccccc1NC(=O)CSc1nc(N2CCCCC2)nc(N2CCCCC2)n1 CHEMBL1528911 AC50 8.913 nM
CCn1c(=O)c2c(nc3n2CCS3)n(C)c1=O CHEMBL1610942 AC50 8.913 nM
O=C(Nc1ccc2ccccc2c1)c1cc(-c2ccncc2)nc2ccc(Br)cc12 CHEMBL455975 Ki 9.0 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(-c3nccs3)cc2)c2ccc(OCc3ccccn3)cc12 CHEMBL539650 IC50 9.1 nM
Cc1cc(C(=O)NC2CCC(=Cc3cccc(Oc4ccc(C(F)(F)F)cn4)c3)CC2)cnc1N CHEMBL4474161 IC50 9.2 nM
Cc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccccn5)ccc43)cc2)cn1 CHEMBL553174 IC50 10.0 nM
COc1ccc(-c2coc3cc(O)ccc3c2=O)cc1 CHEMBL242341 Potency 10.0 nM
CC1=C/C(=C(/c2ccc(O)c(C)c2)c2ccccc2C(=O)O)C=CC1=O CHEMBL1437054 Potency 10.0 nM
CC(=O)NCCNc1ncncc1-c1ccccc1C CHEMBL1475358 Potency 10.0 nM
COc1cccc(Cn2c(=O)c(-c3cc(F)cc(F)c3)nc3cnc(N4CCOCC4)nc32)c1 CHEMBL1479202 Potency 10.0 nM
CN1CCN(c2ccc([N+](=O)[O-])c(N/N=C3\CN4CCC3CC4)c2)CC1 CHEMBL3198738 AC50 10.0 nM
CC12COC3(C(=O)Nc4nccs4)CC1CCC32C CHEMBL1525292 AC50 10.0 nM
COC(=O)[C@H](Cc1ccccc1)NC(=O)N1CCN(Cc2ccccc2)CC1 CHEMBL1383786 AC50 10.0 nM
O=C(NC[C@]1(CC2CC2)CC[C@@H](S(=O)(=O)c2c[nH]nn2)CC1)c1ccc(Cl)cc1Cl CHEMBL2146710 IC50 10.0 nM
Cc1cc(C)c2nc(-c3ccncc3)cc(C(=O)Nc3ccc4ccccc4c3)c2c1 CHEMBL464595 Ki 11.0 nM
CCCC(=O)Nc1nc2nc(-c3ccccc3)cc(-c3ccccc3)n2n1 CHEMBL1584624 AC50 11.22 nM
O=C(Nc1ccc2ccccc2c1)c1cc(-c2ccncc2)nc2ccc(Cl)cc12 CHEMBL455976 Ki 12.0 nM
Cc1ccc(COc2ccc3c(c2)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n3Cc2ccc(-c3ccc(C)cn3)cc2)nc1 CHEMBL1922662 IC50 12.0 nM
Cc1ccccc1OCCNC=C1C(=O)N(C)C(=O)N(C)C1=O CHEMBL1411881 AC50 12.59 nM
C=CC[C@@H]1C=C[C@@H](O/N=C(/C)CCC(=O)OC[C@@H]2O[C@H](c3ccccc3)C=C[C@@H]2Oc2ccc(OC)cc2)[C@@H](CO)O1 CHEMBL1317010 AC50 12.59 nM
Cc1ccc(SCc2ccc(C(=O)NCc3ccncc3)cc2)cc1 CHEMBL1418864 AC50 12.59 nM
CN1CCN(c2ncc3nc(-c4ccc(Cl)cc4)c(=O)n(-c4ccccc4)c3n2)CC1 CHEMBL1478430 AC50 12.59 nM
COCCCn1nnnc1SCC(=O)N1CCCC1 CHEMBL1741665 AC50 12.59 nM
CN1CCN(c2ncc3nc(-c4ccc(F)cc4)c(=O)n(Cc4cccs4)c3n2)CC1 CHEMBL1335967 AC50 12.59 nM
COc1ccc(-c2cnnc(CCCn3ccnc3-c3ccccc3)n2)cc1 CHEMBL1354913 AC50 12.59 nM
Clc1ccc(CC[C@H](Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1 CHEMBL1317950 AC50 12.59 nM
C=C(CO)[C@H]1Cc2c(ccc3c(=O)c4c(oc23)COc2cc(OC)c(OC)cc2-4)O1 CHEMBL1456805 Potency 12.6 nM
CC(=O)c1c(O)c(C)c(O)c2c1OC1=CC(=O)[C@H](C(C)=O)C(=O)[C@]12C CHEMBL373338 Potency 12.6 nM
COc1ccc(CCN(C)CCC[C@@](C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC CHEMBL36148 Potency 12.6 nM
O=S(=O)(Nc1ccc(Cc2ccncc2)cc1)c1ccc(Br)cc1 CHEMBL1299525 AC50 14.13 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(-c3cccnc3)cc2)c2ccc(OCc3ccccn3)cc12 CHEMBL538632 IC50 15.5 nM
CCNc1ncc2nc(-c3ccccc3)c(=O)n(Cc3ccc(F)cc3)c2n1 CHEMBL1593545 Potency 15.8 nM
COc1ccc(CNc2ncnc3ccc(-c4cccc(C#N)c4)cc23)c(OC)c1 CHEMBL491939 Potency 15.8 nM
COc1ccccc1CNc1ccnc(-c2ccccc2C(F)(F)F)n1 CHEMBL1446009 Potency 15.8 nM
FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 CHEMBL27006 Potency 15.8 nM
O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12 CHEMBL81 Potency 15.8 nM
N#C/C(=C\c1ccc(O)c(O)c1)C(=O)NCCCCc1ccccc1 CHEMBL440298 Potency 15.8 nM
COc1cc(OC)cc([C@H](CNc2ncnc3c2ncn3[C@@H]2O[C@@H](CO)[C@H](O)[C@@H]2O)c2ccccc2C)c1 CHEMBL1533121 Potency 15.8 nM
CCCC1CCC(c2ccc(C(N)=O)cc2)CC1 CHEMBL1605333 AC50 15.85 nM
Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 CHEMBL104 IC50 16.0 nM
CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 CHEMBL163 IC50 16.0 nM
CC(C)OC(=O)CSc1nc(-c2ccc(F)cc2)nc2ccc(F)cc12 CHEMBL1703723 AC50 17.78 nM
Clc1ccc(CS[C@@H](Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 CHEMBL1446716 AC50 19.95 nM
CCOc1ccc(C(Nc2ccc(C)cc2)P2(=O)OCC(C)(C)CO2)cc1 CHEMBL1429056 AC50 19.95 nM
CCC(C)(C)n1nnnc1C(c1cc2cc3c(cc2nc1O)OCO3)N1CCCCC1 CHEMBL1447970 AC50 19.95 nM
O=C(O)C(Sc1ccc(Cl)cc1)Sc1ccc(Cl)cc1 CHEMBL1375127 AC50 19.95 nM
O=S(=O)(Nc1ccc(Cc2ccncc2)cc1)c1ccc(Cl)c(Cl)c1 CHEMBL1390261 AC50 19.95 nM
O=S(=O)(Nc1ccc(Cc2ccncc2)cc1)c1cccs1 CHEMBL1330299 AC50 19.95 nM
COc1ccc(OC2C=CC(C#Cc3ccc(F)cc3F)OC2CO)cc1 CHEMBL1445792 Potency 20.0 nM
COCCn1c(=O)c(-c2ccc(F)cc2)nc2cnc(Nc3cccc(OC)c3)nc21 CHEMBL1553136 Potency 20.0 nM
Cc1noc(C)c1-c1nccc(-n2ccnc2)n1 CHEMBL1568178 Potency 20.0 nM
O=C1Nc2ccccc2/C1=C\c1ccc2c(/C=C/c3ccncc3)n[nH]c2c1 CHEMBL2407749 IC50 20.0 nM
OCCN(/C=N/C1=NN(c2cccc(C(F)(F)F)c2)CC1)CCO CHEMBL3210786 AC50 22.39 nM
CCOc1ccc(C2C(C#N)=C(N)Oc3c2c(=O)oc2ccccc32)cc1 CHEMBL1323317 AC50 22.39 nM
Cc1cc(N)ccc1NC(=O)c1ccccc1 CHEMBL1470888 AC50 22.39 nM
CN(C)N1C(N)=C(C#N)C(c2cccnc2)C2=C1CC(C)(C)CC2=O CHEMBL1741331 AC50 22.39 nM
COc1ccccc1CNC(=O)C1CC(=O)N(C2CCCC2)C1 CHEMBL1364047 AC50 22.39 nM
CCc1oc2ccccc2c(=O)c1C(=O)c1cc(I)c(O)c(I)c1 CHEMBL458566 Ki 23.0 nM
O=c1oc2ccccc2c(O)c1Cc1c(O)c2ccccc2oc1=O CHEMBL1466 Potency 25.1 nM
COc1ccc(-c2coc3cc(O)cc(O)c3c2=O)cc1 CHEMBL131921 Potency 25.1 nM
COc1ncc2nc(-c3cn(C)c4ccccc34)c(=O)n(CCc3ccccc3)c2n1 CHEMBL1433687 Potency 25.1 nM
CN(C)CC[C@H](c1ccc(Cl)cc1)c1ccccn1 CHEMBL1554789 Potency 25.1 nM
CC(C)CC(=O)N1CCN(Cc2cccc(F)c2)CC1 CHEMBL1606137 AC50 25.12 nM
CC1CC(OCC(O)CN2CCN(Cc3ccccc3)CC2)CC(C)(C)C1 CHEMBL1560697 AC50 25.12 nM
O=C(NCCNS(=O)(=O)c1ccc(Cl)cc1)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F CHEMBL1602661 AC50 25.12 nM
O=C(O)c1ccccc1C(=O)NNc1ccc(F)cc1 CHEMBL1537973 AC50 25.12 nM
O=C(COc1ccc([N+](=O)[O-])cc1)NN=C1CCCC1 CHEMBL1507561 AC50 25.12 nM
CCCc1nnc(SCC(=O)N2CCCCC2C)n1CCCOC CHEMBL1741657 AC50 25.12 nM
CCOC(=O)c1ccc(NC(=O)C2CCCO2)cc1 CHEMBL1469212 AC50 25.12 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccccn5)ccc43)cc2)nn1 CHEMBL552567 IC50 26.9 nM
COc1nn(C(C)C(=O)N/N=C/c2ccc(O)cc2)cc1[N+](=O)[O-] CHEMBL3214111 AC50 28.18 nM
COc1ccc(CNCCc2ccccc2)cc1OCC(N)=O CHEMBL1578522 AC50 28.18 nM
COC(=O)CSC1=C(C#N)C(c2cccc(F)c2)CC(=O)N1 CHEMBL1430842 AC50 28.18 nM
Cc1ccc(C(=O)CSc2nc(C)cc(O)n2)cc1 CHEMBL1720191 AC50 28.18 nM
COc1ccc(-n2cnnc2)cc1 CHEMBL1723292 AC50 28.18 nM
CC(=O)N1CCC(=O)N(C(C)C)c2ccccc21 CHEMBL1728064 AC50 28.18 nM
Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12 CHEMBL565591 IC50 30.0 nM
O=C1Nc2ccccc2[C@]12C[C@H]2c1ccc2c(/C=C/c3ccncc3)n[nH]c2c1 CHEMBL3353340 IC50 30.0 nM
CNC(=O)/C=C/c1cc(OC)cc(-c2ccc3cc(OC)ccc3c2)c1 CHEMBL3645225 IC50 30.0 nM
Cn1cc(-c2nc3c(N4CCN(Cc5cccnc5)CC4)c(Br)cnc3[nH]2)cn1 CHEMBL3898132 IC50 30.0 nM
Cc1nn(C)c(C)c1-c1nc2c(N3CCN(Cc4cccnc4)CC3)c(Br)cnc2[nH]1 CHEMBL3891461 IC50 30.0 nM
Cc1nn(C)cc1-c1nc2c(N3CCN(Cc4ccc(Cl)cc4)CC3)c(Cl)cnc2[nH]1 CHEMBL2207503 IC50 30.0 nM
Cc1nn(C)cc1-c1nc2c(N3CCN(Cc4ncon4)CC3)c(Cl)cnc2[nH]1 CHEMBL2207500 IC50 30.0 nM
Cc1nc(CN2CCN(c3c(Cl)cnc4[nH]c(-c5cn(C)nc5C)nc34)CC2)no1 CHEMBL2207501 IC50 30.0 nM
CC(c1cccc(C(F)(F)F)c1)c1nc(-n2ccc(NC(=O)c3cscn3)cc2=O)c[nH]1 CHEMBL3810245 IC50 31.0 nM
Fc1ccc(C(OCCCc2c[nH]cn2)c2ccc(F)cc2)cc1 CHEMBL1179104 Potency 31.6 nM
C=CCOCC/C=C1/c2ccccc2C(OC)C1C CHEMBL1593596 Potency 31.6 nM
CC(C)=CCC/C(C)=C/COc1c2ccoc2cc2oc(=O)ccc12 CHEMBL1078442 Potency 31.6 nM
CC(C)(C)c1cc(C=C(C#N)C#N)cc(C(C)(C)C)c1O CHEMBL78150 Potency 31.6 nM
CN1CCN(c2ncncc2-c2ccc(N(C)C)cc2)CC1 CHEMBL1442011 Potency 31.6 nM
COc1ccc(-c2c[n+]3c4n2CCCCC4=C(c2ccccc2)C3)cc1 CHEMBL1490799 AC50 31.62 nM
O=C(Nc1ccc2ccccc2c1)c1cc(-c2ccncc2)nc2ccccc12 CHEMBL456181 Ki 33.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@H]2NCCC=C2c2ccc(F)cc2)cc1F CHEMBL4102132 IC50 33.0 nM
C=CCC(C)(NCc1ccccc1)c1ccco1 CHEMBL1726069 AC50 35.48 nM
CCOc1cc(NC(=O)c2cccs2)c(OCC)cc1NC(=O)c1ccco1 CHEMBL1404955 AC50 35.48 nM
Cc1cc(C)n(CC(O)COc2ccccc2)n1 CHEMBL1373202 AC50 35.48 nM
O=C(OCC(=O)c1ccc([N+](=O)[O-])cc1)/C(=C\c1ccc(Cl)cc1)NC(=O)c1ccccc1 CHEMBL1506008 AC50 35.48 nM
Cc1ccc(NC(=O)C2CC(=O)n3c(nc4ccccc43)N2)cc1 CHEMBL1429809 AC50 35.48 nM
CC(c1ccccc1C(O)c1ccccc1)N(C)C CHEMBL1360641 AC50 35.48 nM
CCOC(=O)N(c1ccccc1)P1(=S)OCCO1 CHEMBL1481573 AC50 35.48 nM
N#Cc1cc(S(=O)(=O)Nc2nccs2)ccc1Oc1ccc(Cl)cc1-c1cn[nH]c1 CHEMBL2325016 IC50 36.0 nM
Cn1nccc1-c1cc(Cl)ccc1Oc1cc(F)c(S(=O)(=O)Nc2cscn2)cc1Cl CHEMBL2324405 IC50 37.0 nM
CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccccc3N(Cc3c[nH]cn3)C(CCc3ccccc3)C2)cc1 CHEMBL8332 IC50 38.0 nM
CC(=O)N[C@H]1CC[C@H](Nc2nccc(-n3nnc4ccccc43)n2)CC1 CHEMBL2425651 IC50 39.0 nM
Cn1nccc1-c1cc(Cl)ccc1Oc1cc(F)c(S(=O)(=O)Nc2ncns2)cc1F CHEMBL2325350 IC50 39.0 nM
COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(C(C)=O)cc3)cc2)CC1 CHEMBL294747 Potency 39.8 nM
CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 CHEMBL998 Potency 39.8 nM
CN(C)c1nc(-c2cccc(C#N)c2)nc2ccccc12 CHEMBL1533572 Potency 39.8 nM
Cc1ccc(S(=O)(=O)N(Cc2ccccc2)c2ccccc2C(=O)NCc2ccco2)cc1 CHEMBL1335865 AC50 39.81 nM
Cc1nc(-c2cccnc2)sc1C(=O)Nc1ccc(Cl)cc1 CHEMBL1490820 AC50 39.81 nM
C/C(=C/C(=O)NCc1ccccc1)C(=O)O CHEMBL1610199 AC50 39.81 nM
CCN(C1CCCCC1)S(=O)(=O)c1ccc(S(=O)(=O)NCc2ccncc2)cc1 CHEMBL1608942 AC50 39.81 nM
CCCCn1c(SCC(=O)NC(C)(C)C)nnc1-c1ccco1 CHEMBL1483302 AC50 39.81 nM
Cc1ccccc1C(=O)NC(NCc1ccco1)C(Cl)(Cl)Cl CHEMBL1701169 AC50 39.81 nM
CCc1oc2ccccc2c1C(=O)c1cc(C)c(O)c(C)c1 CHEMBL225481 Ki 40.0 nM
O=C1Nc2cc(NC(=O)c3c[nH]cc(-c4ccccc4F)c3=O)ccc2/C1=C/c1ccc[nH]1 CHEMBL3322590 IC50 40.0 nM
Cc1oc2ccccc2c(=O)c1C(=O)c1cc(I)c(O)c(I)c1 CHEMBL458567 Ki 41.0 nM
CCCc1oc2ccccc2c(=O)c1C(=O)c1cc(I)c(OC)c(I)c1 CHEMBL457087 Ki 44.34 nM
COc1ccc(Br)cc1C(=O)Nc1ccc(Cc2ccncc2)cc1 CHEMBL1374962 AC50 44.67 nM
O=C(/C=C/c1cccc(Cl)c1)Nc1ccncc1 CHEMBL1505191 AC50 44.67 nM
Cc1cc(S(=O)(=O)NCCN(C)C)c(C)s1 CHEMBL1423078 AC50 44.67 nM
N#Cc1c(-c2ccccc2)cc(C2CC2)nc1SCC(=O)c1cccs1 CHEMBL1503047 AC50 44.67 nM
Cc1cc(NC(=S)NC(=O)CC(C)C)ccc1Br CHEMBL1605586 AC50 44.67 nM
COc1cc(C(=O)OCC(=O)Nc2cc(C)on2)cc(OC)c1OC CHEMBL1511209 AC50 44.67 nM
O=C(NC(NC(=S)Nc1cc(Cl)ccc1Cl)C(Cl)(Cl)Cl)c1ccco1 CHEMBL1503387 AC50 44.67 nM
Cc1[nH]c2ccc(OC(F)(F)F)cc2c1Cc1cccc(O[C@@H](C)C(=O)O)c1 CHEMBL189785 IC50 50.0 nM
Cc1cc(C)c(NC(=O)Nc2cc3ccccc3cc2C(=O)N[C@H](C(=O)O)[C@@H](CC(C)C)OCc2ccccc2)c(C)c1 CHEMBL444032 IC50 50.0 nM
O=C(NCc1ccc(S(=O)(=O)c2ccccc2)cc1)N1Cc2ccncc2C1 CHEMBL2419505 IC50 50.0 nM
O=C(NCc1ccc(S(=O)(=O)c2ccccc2)cc1)c1cc2ccncc2o1 CHEMBL2419504 IC50 50.0 nM
N#Cc1c(NC(=O)C(F)(F)F)sc2c3c(=O)c4ccccc4c(=O)c=3oc3ccccc3c12 CHEMBL1372282 Potency 50.1 nM
C[C@H](NC(=O)/C(C#N)=C/c1ccc(O)c(O)c1)c1ccccc1 CHEMBL261557 Potency 50.1 nM
CN1CCN2c3ncccc3Cc3ccccc3C2C1 CHEMBL654 Potency 50.1 nM
Nc1ccc(S(=O)(=O)Nc2ccnn2-c2ccccc2)cc1 CHEMBL1109 Potency 50.1 nM
NCCCCCCCCCCNS(=O)(=O)c1cccc2c(Cl)cccc12 CHEMBL1331148 Potency 50.1 nM
COc1cccc(C(=O)NC2CC3CCCC(C2)N3CC(=O)Nc2ccccc2)c1 CHEMBL1449293 AC50 50.12 nM
COc1ccc(-c2csc(-n3ncc(-c4cccs4)c3N)n2)cc1 CHEMBL1349783 AC50 50.12 nM
NC(=O)NCc1ccc(Cl)cc1 CHEMBL1224553 AC50 50.12 nM
CCC(=O)n1nc(-c2ccc(OC)cc2)nc1N CHEMBL1480788 AC50 56.23 nM
CCCc1cc2c(cc1NC(=O)c1ccccc1C)OCO2 CHEMBL1587467 AC50 56.23 nM
CC(C)[C@H](N)c1nnc(SC/C=C/c2ccccc2)o1 CHEMBL1352225 AC50 56.23 nM
O=C(NCc1ccc(S(=O)(=O)c2cc(F)cc(F)c2)cc1)c1cc2cnccc2[nH]1 CHEMBL2420620 IC50 60.0 nM
Cc1cc2c(F)c(Oc3ncnn4cc(OC[C@@H](C)OC(=O)CN)c(C)c34)ccc2[nH]1 CHEMBL270996 IC50 63.0 nM
CNc1nc(C2CCCCC2)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1 CHEMBL2392693 IC50 63.0 nM
CN(Cc1ccco1)c1cc(-c2cccc(C#N)c2)ncn1 CHEMBL1482790 Potency 63.1 nM
O=C1C2CCN(CC2)C1(CO)CO CHEMBL186872 Potency 63.1 nM
CN(C)c1ccc(-c2cc(Nc3ccc(F)cc3)ncn2)cc1 CHEMBL1555014 Potency 63.1 nM
COc1ccc2[nH]cc(CCNc3ncnc4ccc(-c5cccc(C#N)c5)cc34)c2c1 CHEMBL1606727 Potency 63.1 nM
C[C@@H](C(=O)Nc1ccc2ccccc2c1)[C@@H]1C[C@@]1(C)[C@@H](NC(=O)c1cnccn1)c1ccccc1 CHEMBL1488197 Potency 63.1 nM
O=C(N/N=C/c1ccncc1)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1O CHEMBL3191557 AC50 63.1 nM
O=C(Cc1csc(Nc2nc(S)nc3ccccc23)n1)NCc1cccc(Cl)c1 CHEMBL1487063 AC50 63.1 nM
COc1ccccc1NC(=O)CSc1nc2ccccc2cc1Cc1ccccc1 CHEMBL1569843 AC50 63.1 nM
CC(=O)Nc1ccc(OCC(O)Cn2cnc3ccccc32)cc1 CHEMBL1742034 AC50 63.1 nM
CCOC(=S)NC(=O)c1sc2ccccc2c1Cl CHEMBL1493869 AC50 63.1 nM
CC(C)=CC(=O)OCC(=O)Nc1ncc(Cl)c(C)c1Cl CHEMBL1301027 AC50 63.1 nM
c1ccc2c(CSCCc3ccncc3)cccc2c1 CHEMBL1586705 AC50 63.1 nM
O=C(CC1C(=O)N(c2ccc(Cl)cc2)C(=S)N1CCc1ccncc1)Nc1ccc(F)cc1 CHEMBL1450860 AC50 63.1 nM
COc1ccc(Cc2cc3cc(OC)ccc3cc2-c2cccnc2)cc1 CHEMBL494713 IC50 64.0 nM
Nc1ccc(S(=O)(=O)c2ccc(CNC(=O)N3Cc4ccncc4C3)cc2)cn1 CHEMBL2419516 IC50 65.0 nM
CCOc1ccccc1-c1ccc(-c2nc3ccc(F)cc3c(N[C@@H](C)C(=O)O)c2C#N)cc1 CHEMBL397600 IC50 66.0 nM
O=C(NCc1cccnc1)Nc1ccc(S(=O)(=O)c2ccccc2)cc1 CHEMBL2391572 IC50 68.0 nM
CC(C)n1cc(S(=O)(=O)c2ccc(CNC(=O)c3cc4ccncc4o3)cc2)cn1 CHEMBL3394729 IC50 70.0 nM
CCCn1cc(S(=O)(=O)c2ccc(CNC(=O)c3cc4ccncc4o3)cc2)cn1 CHEMBL3394730 IC50 70.0 nM
CCCn1cc(S(=O)(=O)c2ccc(CNC(=O)c3cc4ccncc4o3)nc2)cn1 CHEMBL3394741 IC50 70.0 nM
O=C(NCc1ccc(S(=O)(=O)c2cccc(C(F)(F)F)c2)cc1)c1cnc2[nH]ncc2c1 CHEMBL3260358 IC50 70.0 nM
O=C(CSc1nnc2c(n1)[nH]c1ccc(F)cc12)OCc1ccccc1 CHEMBL1533643 AC50 70.79 nM
CN(C)c1nc2c(c(=O)[nH]c(=O)n2C)n1Cc1ccccc1Br CHEMBL1328247 AC50 70.79 nM
CN(CC(=O)N1CCN(c2ccccc2)CC1)S(=O)(=O)c1c[nH]cn1 CHEMBL1485338 AC50 70.79 nM
CSc1nnc(-c2sc(-c3ccccc3)nc2C)n1C CHEMBL1483077 AC50 70.79 nM
Cc1nn(C)cc1C(=O)NN=C(S)Nc1ccc(F)cc1 CHEMBL1536668 AC50 70.79 nM
C=CCN1C(=O)CN=C1Nc1ccccc1 CHEMBL1422703 AC50 70.79 nM
CC(C)n1cc(S(=O)(=O)c2ccc(CNC(=O)N3Cc4ccncc4C3)cc2)cn1 CHEMBL2419518 IC50 73.0 nM
O=C(NCc1cncc(F)c1)Nc1ccc(S(=O)(=O)c2ccccc2)cc1 CHEMBL2393185 IC50 74.0 nM
Cc1ccc(S(=O)(=O)c2ccc(CNC(=O)N3Cc4ccncc4C3)cc2)cn1 CHEMBL2419515 IC50 77.0 nM
COc1cc(-c2ccc(Cl)c(C)c2)ccc1-n1c(=O)ccc2cc(S(=O)(=O)Nc3ccncn3)ccc21 CHEMBL3965976 IC50 78.0 nM
Cc1noc(C)c1-c1cc(NC2CCNCC2)ncn1 CHEMBL1611630 Potency 79.4 nM
S=C(NC1CCCCC1)N1CCC(c2cnc[nH]2)CC1 CHEMBL260374 Potency 79.4 nM
COc1ccc(CCCOc2cc(CCn3ccnc3)ccc2OC)cc1 CHEMBL1332270 Potency 79.4 nM
COC(=O)[C@@H]1[C@@H](O)[C@]2(O)c3ccccc3O[C@]2(c2ccccc2)[C@H]1c1ccccc1 CHEMBL1561829 Potency 79.4 nM
O=c1c2ccccc2[se]n1-c1ccccc1 CHEMBL51085 Potency 79.4 nM
CS(=O)(=O)N1CCC2(CCCN(c3ccncc3)C2)CC1 CHEMBL1553056 Potency 79.4 nM
O=C1Nc2ccc(I)cc2/C1=C/c1cc(Br)c(O)c(Br)c1 CHEMBL72365 Potency 79.4 nM
O=C(O)c1c(Cl)c(Cl)c(Cl)c(Cl)c1C(=O)Nc1ccc2cn[nH]c2c1 CHEMBL471226 Potency 79.4 nM
CCOC(=O)OCC1OC(C#Cc2ccccc2)C=CC1OC(=O)OCC CHEMBL1565169 Potency 79.4 nM
O=C(Nc1cccc(F)c1)N1CCCC2(CCN(C(=O)c3ccncc3)CC2)C1 CHEMBL1594648 Potency 79.4 nM
O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC[C@@]2(CCN(Cc3ccncc3)C2)C1 CHEMBL1356842 Potency 79.4 nM
Clc1ccc(CSCCc2ccncc2)cc1Cl CHEMBL1565311 Potency 79.4 nM
CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 CHEMBL3185958 Potency 79.4 nM
O=S(=O)(c1ccccc1)N1CCC2(CCCN(Cc3ccncc3)C2)CC1 CHEMBL1396862 Potency 79.4 nM
C=CC[C@@H]1C=C[C@H](O/N=C(\C)CCN2CCc3nc(-c4ccccc4)c(-c4ccccc4)cc3C2)[C@H](CO)O1 CHEMBL1491776 Potency 79.4 nM
O=C(Cn1c(CCc2cccc(F)c2F)nc(=O)c2ccccc21)N(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C1CCN(c2ccncn2)CC1 CHEMBL1170483 pIC50 79.43 nM
Cc1c(Cl)cccc1NC(=O)c1ccc(-n2ccnc2)nc1 CHEMBL1522673 AC50 79.43 nM
Clc1ccc(-c2ccnc(Oc3cc(Cl)ccc3Cl)n2)cc1 CHEMBL1418866 AC50 79.43 nM
CC(=O)/N=c1\sccn1CC(=O)c1ccc([N+](=O)[O-])cc1 CHEMBL1985310 AC50 79.43 nM
CC1(C)CC(=O)C2=C(C1)N(Cc1cccnc1)C(=O)C2(NC(=O)c1cccnc1)C(F)(F)F CHEMBL1507467 AC50 79.43 nM
Cc1ccc(Nc2ccc(-n3ccnc3)nn2)cc1C CHEMBL1484866 AC50 79.43 nM
Nn1c(SCC(=O)N2CCOCC2)nnc1-c1ccccc1Cl CHEMBL1393272 AC50 79.43 nM
Cc1ccc(S(=O)(=O)NC2=NC(=O)/C(=C/c3cccnc3)S2)cc1 CHEMBL1501140 AC50 79.43 nM
Cc1cc(C)n(-c2ccc(C(=O)Nc3cc(C(F)(F)F)ccc3N3CCOCC3)cc2)n1 CHEMBL1421734 AC50 79.43 nM
O=C(NCc1ccc(S(=O)(=O)C2CCCCC2)cc1)N1Cc2ccncc2C1 CHEMBL2417572 IC50 80.0 nM
N#Cc1cc(S(=O)(=O)Nc2ncns2)ccc1Oc1ccc(Cl)cc1-c1cn[nH]c1 CHEMBL2325330 IC50 83.0 nM
COC(=O)N[C@@H](C(=O)N1CCC[C@H]1C(=O)Nc1ccc(-c2ccc(NC(=O)[C@@H]3CCCN3C(=O)[C@H](NC(=O)OC)c3ccccc3)cc2F)c(F)c1)c1ccccc1 CHEMBL3608915 EC50 87.7 nM
CCCCOc1ccc(-n2cncc2C)cc1 CHEMBL358880 IC50 88.0 nM
Cc1ccc(-n2c(SCc3ccc([N+](=O)[O-])cc3)nc3ccccc3c2=O)cc1 CHEMBL1376830 AC50 89.13 nM
CC(=O)n1cc(/C=N/NC(=O)c2sc(C)nc2C)c2ccccc21 CHEMBL1975888 AC50 89.13 nM
O=C1c2ccccc2C2=Nc3ccccc3SC(c3ccccc3F)C12 CHEMBL606167 AC50 89.13 nM
C/C(=C\c1ccco1)C1C(C#N)=C(N)Oc2[nH]nc(-c3ccccc3)c21 CHEMBL1420830 AC50 89.13 nM
O=C(CCCn1c(=S)[nH]c2cc3c(cc2c1=O)OCO3)N1CCN(c2ccccc2)CC1 CHEMBL1419356 AC50 89.13 nM
CC(=O)c1c(O)c(C)c(O)c2c1OC1=CC(=O)c3c(n[nH]c3C)[C@@]12C CHEMBL5278512 IC50 94.0 nM
CCCCOc1ccc(-n2ccnc2)cc1 CHEMBL112532 IC50 96.0 nM
COc1ccc(CN2CCN(c3ccc(NC(=O)c4cc(OC)c(OC)cc4NC(=O)c4cnc5ccccc5c4)cc3)CC2)cc1OC CHEMBL242983 IC50 96.8 nM