CN(C)c1ccc(NC(=O)c2cc(-c3ccccc3)nc3ccccc23)cc1 CHEMBL2152011 Km 0.0 nM
CN(C)c1ccc(NC(=O)c2cc(-c3ccncc3)nc3ccccc23)cc1 CHEMBL2152015 Km 0.0 nM
COCCCN1C[C@@H]2[C@@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@@H]2C1 CHEMBL3740472 IC50 0.0 nM
CCCCOc1ccc(-n2ccnc2)cc1 CHEMBL112532 pIC50 0.0001324 nM
CC[C@@]1(N)CCCN(c2cc3c(c(=O)n(C)c(=O)n3C)n2Cc2cc(F)ccc2C#N)C1 CHEMBL1819091 Ki 0.022 nM
Cn1c(=O)c2c(cc(N3CCC[C@@H](N)C3)n2Cc2cc(F)ccc2C#N)n(C)c1=O CHEMBL1819089 Ki 0.026 nM
COc1cc(NC(=O)C[C@@]2(C)C[C@H](c3cccc(Cl)c3)[C@@H](c3ccc(Cl)cc3)N([C@H](CS(=O)(=O)C(C)(C)C)C3CC3)C2=O)ccc1C(=O)O CHEMBL3407558 IC50 0.0503 nM
CC(C)(C)S(=O)(=O)C[C@H](C1CC1)N1C(=O)[C@@](C)(CC(=O)O)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1 CHEMBL3125537 IC50 0.0962 nM
CC(C)(C)S(=O)(=O)C[C@H](C1CC1)N1C(=O)[C@@](C)(CC(=O)O)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)c(F)c1 CHEMBL3407554 IC50 0.102 nM
CC(C)[C@@H]1COC[C@H](C2(OC(=O)N3CCNCC3)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL1271703 IC50 0.3 nM
COc1cc(NC(=O)C[C@@]2(C)C[C@H](c3cccc(Cl)c3)[C@@H](c3ccc(Cl)c(F)c3)N([C@H](CS(=O)(=O)C(C)(C)C)C3CC3)C2=O)ccc1C(=O)O CHEMBL3407575 IC50 0.33 nM
Cc1cc(N2CCC(O)CC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL520419 IC50 0.4 nM
O=C(NC1CCC(=Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1)c1cccnc1 CHEMBL4593464 IC50 0.4 nM
Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL401930 IC50 0.5 nM
Cc1cc(N2CCC(N3C[C@@H]4C[C@@H]3CO4)CC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL474469 IC50 0.5 nM
COC(=O)NC1CCN(c2cc(C)c3nc(-c4c(NC[C@@H](O)c5cccc(Cl)c5)cc[nH]c4=O)[nH]c3c2)CC1 CHEMBL521271 IC50 0.5 nM
CC(C)[C@@H]1COC[C@H](C2(OC(=O)N3CC4CCC(C3)N4)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL1271544 IC50 0.5 nM
CC1([C@@H]2COC[C@H](COC(=O)N3CCN(C(C)(C)CO)CC3)N2S(=O)(=O)c2ccc(Cl)cc2)CC1 CHEMBL1271822 IC50 0.5 nM
Cc1cc(N2CCC(NC(=O)C3CC3)CC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL480966 IC50 0.7 nM
Cc1cc(N2CCC3(CC2)OCCO3)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL482101 IC50 0.7 nM
CC(=O)N1CCN(C2CCN(c3cc(C)c4nc(-c5c(NC[C@@H](O)c6cccc(Cl)c6)cc[nH]c5=O)[nH]c4c3)CC2)CC1 CHEMBL506169 IC50 0.8 nM
O=C(OC1([C@H]2COC[C@@H](CC3CC3)N2S(=O)(=O)c2ccc(Cl)cc2)CC1)N1CC2CCC(C1)N2 CHEMBL1271879 IC50 0.8 nM
COCCOC1CCN(c2cc(C)c3nc(-c4c(NC[C@@H](O)c5cccc(Cl)c5)cc[nH]c4=O)[nH]c3c2)CC1 CHEMBL482088 IC50 0.9 nM
CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1C(=O)NCCc1ccc(S(N)(=O)=O)cc1 CHEMBL4636136 IC50 0.9 nM
O=C1CC(c2cccc(-n3ccnc3)c2)=Nc2ccc(-c3ccccc3F)cc2N1 CHEMBL260636 IC50 1.0 nM
O=C1CC(c2cccc(-n3ccnc3)c2)=Nc2cc(O)c(-c3ccccc3F)cc2N1 CHEMBL405895 IC50 1.0 nM
COCCN(CCOC)C1CCN(c2cc(C)c3nc(-c4c(NC[C@@H](O)c5cccc(Cl)c5)cc[nH]c4=O)[nH]c3c2)CC1 CHEMBL454467 IC50 1.0 nM
COC1CCN(c2cc(C)c3nc(-c4c(NC[C@@H](O)c5cccc(Cl)c5)cc[nH]c4=O)[nH]c3c2)CC1 CHEMBL519132 IC50 1.0 nM
Cc1cncc(Oc2c(Cl)cc(NS(=O)(=O)c3ccc(Cl)cc3Cl)cc2Cl)c1 CHEMBL2338480 IC50 1.0 nM
CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL157101 IC50 1.0 nM
CC(C)O[C@H]1CC[C@H](C(=O)N2Cc3cccnc3Nc3ccc(N4CC5CCC4CO5)cc32)OC1 CHEMBL5079148 IC50 1.0 nM
Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 CHEMBL91 IC50 1.0 nM
CC(=O)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL75 IC50 1.0 nM
C/C=C1\C[N@@+]2(C)CC[C@@]34C(=C(C=O)[C@H]1C[C@H]32)Nc1ccccc14 CHEMBL1318754 AC50 1.259 nM
O=C(O)c1ccccc1C(=O)Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 CHEMBL1524273 AC50 1.259 nM
Cc1cc(N2CCC(OCCO)CC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL482089 IC50 1.3 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(-c3nccs3)cc2)c2ccc(OCc3ccccn3)cc12 CHEMBL539650 IC50 1.4 nM
CN1CCN(C(=O)OC2([C@H]3COC[C@@H](CC4CC4)N3S(=O)(=O)c3ccc(Cl)cc3)CC2)CC1=O CHEMBL1272097 IC50 1.4 nM
C[C@@H](C[C@@H](CS(=O)(=O)N1CCN(c2ccc(F)cc2)CC1)N(O)C=O)c1ncc(F)cn1 CHEMBL1683443 IC50 1.4 nM
CC1([C@@H]2COC[C@H](COC(=O)N3CCC(N4CCCCC4)CC3)N2S(=O)(=O)c2ccc(Cl)cc2)CC1 CHEMBL1271821 IC50 1.5 nM
Cc1cc(N2CCC(N3CCN(C(=O)C4CC4)CC3)CC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL510298 IC50 1.7 nM
Cc1cc(N2CCC(N3CCN(C(=O)OCCO)CC3)CC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL505652 IC50 1.8 nM
CC(C)(C)S(=O)(=O)C[C@H](C1CC1)N1C(=O)[C@@](C)(CC(N)=O)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1 CHEMBL3236364 IC50 1.83 nM
C[C@@H]1CN(C(=O)OC2([C@H]3COC[C@@H](CC4CC4)N3S(=O)(=O)c3ccc(Cl)cc3)CC2)C[C@H](C)N1CCO CHEMBL1272046 IC50 2.0 nM
CCOc1ccc(-c2ccc(-c3cc(CC(=O)[O-])ccc3OC)c(CN(CC)C(=O)C3CC3)c2)cn1 CHEMBL1668898 IC50 2.0 nM
O=C(OC1([C@H]2COC[C@@H](CC3CC3)N2S(=O)(=O)c2ccc(Cl)cc2)CC1)N1CC2CCC(C1)N2CCO CHEMBL1271880 IC50 2.3 nM
COCCOC(=O)N1CCN(C2CCN(c3cc(C)c4nc(-c5c(NC[C@@H](O)c6cccc(Cl)c6)cc[nH]c5=O)[nH]c4c3)CC2)CC1 CHEMBL450610 IC50 2.4 nM
Cc1cc(N2CCC(N3CCN(C)CC3)CC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL451331 IC50 2.4 nM
CNC1CCN(c2cc(C)c3nc(-c4c(NC[C@@H](O)c5cccc(Cl)c5)cc[nH]c4=O)[nH]c3c2)CC1 CHEMBL482102 IC50 2.6 nM
COCCOCC(=O)N1CCN(C2CCN(c3cc(C)c4nc(-c5c(NC[C@@H](O)c6cccc(Cl)c6)cc[nH]c5=O)[nH]c4c3)CC2)CC1 CHEMBL502778 IC50 3.0 nM
Cc1cc(C)cc(COc2ccc(N(CCN)C(=O)c3ccc(Cl)cc3Cl)cc2)c1 CHEMBL4088945 IC50 3.0 nM
Cc1cc(N2CCC(N3C[C@@H](C)O[C@@H](C)C3)CC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL502092 IC50 3.1 nM
O=C(c1c(O)nc2cc(Cl)ccc2c1O)C1CC1 CHEMBL115225 AC50 3.162 nM
O=C(OC1([C@H]2COC[C@@H](CC3CC3)N2S(=O)(=O)c2ccc(Cl)cc2)CC1)N1CC2CC1CN2CCO CHEMBL1272045 IC50 3.2 nM
COC(=O)N1CCN(C2CCN(c3cc(C)c4nc(-c5c(NC[C@@H](O)c6cccc(Cl)c6)cc[nH]c5=O)[nH]c4c3)CC2)CC1 CHEMBL505919 IC50 3.5 nM
Cc1cc(N2CCC(N(C)C)CC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL519300 IC50 3.9 nM
COC(=O)Cc1ccc(COc2ccc3cc(C(C(C)N(C)C)n4ccnc4)ccc3c2)cc1 CHEMBL179825 IC50 4.0 nM
CC(C(c1ccc2cc(OCc3ccc(CC(=O)O)cc3)ccc2c1)n1ccnc1)N(C)C CHEMBL180348 IC50 4.0 nM
CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNC1(c2cccc(C(C)(C)C(F)F)c2)CC1 CHEMBL1270362 IC50 4.0 nM
CC[C@@H](C)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@H]5CO[C@](Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O CHEMBL1835951 IC50 4.0 nM
CC[C@H](C)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@H]5CO[C@](Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O CHEMBL1835950 IC50 4.0 nM
CC[C@H](C)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@@H]5CO[C@@](Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O CHEMBL1835949 IC50 4.0 nM
CC[C@@H](C)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@@H]5CO[C@@](Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O CHEMBL454471 IC50 4.0 nM
Cc1cc(N2CCC(N3CCOCC3)CC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL482126 IC50 4.1 nM
Cc1cc(N2CCC(N3CCCC3)CC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL480965 IC50 4.5 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(-c3cccnc3)cc2)c2ccc(OCc3ccccn3)cc12 CHEMBL538632 IC50 4.7 nM
NC(=O)c1ccccc1 CHEMBL267373 Potency 5.0 nM
CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@H](CC[C@H](Cc2ccccc2)NC(=O)OCc2cccnc2)Cc2ccccc2)C(C)C)cs1 CHEMBL2347183 Ks 5.0 nM
CC1([C@@H]2COC[C@H](COC(=O)N3CCC(CO)CC3)N2S(=O)(=O)c2ccc(Cl)cc2)CC1 CHEMBL1271763 IC50 5.5 nM
Cc1ccc(COc2ccc3c(c2)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n3Cc2ccc(-c3ccc(F)cn3)cc2)nc1 CHEMBL1922663 IC50 5.5 nM
COCC(=O)N1CCN(C2CCN(c3cc(C)c4nc(-c5c(NC[C@@H](O)c6cccc(Cl)c6)cc[nH]c5=O)[nH]c4c3)CC2)CC1 CHEMBL499584 IC50 5.6 nM
CCCn1nc(Oc2nc(NCC)nc(NC(C)C)n2)ccc1=O CHEMBL1736877 AC50 5.623 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4ccccc4n3)cc12 CHEMBL16596 IC50 5.8 nM
CCN(CC)C(c1cccc(Nc2ccnc3cc(Cl)ccc23)c1)c1nnnn1C(C)(C)C CHEMBL2413881 IC50 6.0 nM
CC(C)S(=O)(=O)n1c(N)nc2ccc(-c3[nH]c(-c4c(F)cccc4F)nc3-c3ccccc3)cc21 CHEMBL364572 IC50 6.3 nM
C[C@@]12C(=O)OC(=O)[C@@]1(C)[C@H]1CC[C@@H]2O1 CHEMBL1512933 Potency 6.3 nM
OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1 CHEMBL1524185 Potency 6.3 nM
CC(C)[C@@H]1COC[C@H](C2(OC(=O)N3CC4CNCC4C3)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL1271652 IC50 6.4 nM
CC(C)(C)[C@@H]1COC[C@H](COC(=O)N2CCC(CO)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL1271762 IC50 7.1 nM
Nc1cc(Cc2ccn(-c3cccc(-c4ccccc4)c3)n2)c2nn[nH]c2n1 CHEMBL4855931 IC50 7.1 nM
Cc1ccc(COc2ccc3c(c2)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n3Cc2ccc(-c3ccc(C)cn3)cc2)nc1 CHEMBL1922662 IC50 8.5 nM
COc1cnc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccc(C)cn5)ccc43)cc2)nc1 CHEMBL1229205 IC50 8.8 nM
CC(C)(c1ccc(-c2ccncc2)o1)N1CCN(C[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3OC[C@H]2O)[C@H](C(=O)NCC(F)(F)F)C1 CHEMBL3706620 IC50 10.0 nM
COC(=O)c1ccc(COc2ccc3cc(C(C(C)N(C)C)n4ccnc4)ccc3c2)cc1 CHEMBL178474 IC50 10.0 nM
Oc1ccc2c3c1O[C@H]1c4[nH]c5ccccc5c4C[C@]4(O)[C@H](C2)N(CC2CC2)CC[C@@]314 CHEMBL1371444 Potency 10.0 nM
Cc1cccc(C)c1NC1=NCCCS1 CHEMBL297362 Potency 10.0 nM
N#Cc1cncc(Oc2c(Cl)cc(NS(=O)(=O)c3ccc(Cl)cc3Cl)cc2Cl)c1 CHEMBL2338479 IC50 10.0 nM
Cc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2cc(N3CCOCC3)ncc2[nH]1)C(F)(F)F CHEMBL3358929 IC50 10.0 nM
CC(C)(CC(O)(Cc1cc2cc(N3CCOCC3)ncc2[nH]1)C(F)(F)F)c1ccccc1S(C)(=O)=O CHEMBL3358937 IC50 10.0 nM
NCCN(C(=O)c1ccc(F)cc1C(F)(F)F)c1ccc(OCc2ccc(Cl)cc2)cc1 CHEMBL4065918 IC50 10.0 nM
OC(CC1c2cc(Cl)ccc2-c2cncn21)C1CCCCC1 CHEMBL4546052 IC50 10.0 nM
CC(C)C(CC(=O)O)c1ccc(Cl)c(NC(=O)[C@H](c2ccc(Cl)cc2)[C@@H](C)C(F)(F)F)c1 CHEMBL4850605 Activity 10.0 nM
N#Cc1ccc(-c2ccc(NC(=O)Nc3ccc(-c4ccnc5[nH]cnc45)cc3)cc2)cc1 CHEMBL1951444 IC50 11.0 nM
Nc1cc(Cc2ccn(Cc3cccc(Oc4ccccc4)c3)n2)c2nn[nH]c2n1 CHEMBL4862053 IC50 11.0 nM
COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC CHEMBL6966 IC50 11.0 nM
O=C(OC1([C@H]2COC[C@@H](CC3CC3)N2S(=O)(=O)c2ccc(Cl)cc2)CC1)N1CCC2(CCN2)CC1 CHEMBL1272153 IC50 11.3 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccccn3)cc12 CHEMBL38958 IC50 11.5 nM
COCCCN1CCCc2ccc(OC[C@H]3CNCC(=O)N3c3ccc(OCCCOCc4ccccc4OC)cc3)cc21 CHEMBL377531 IC50 12.0 nM
N#CCCn1c(=O)c(CCc2ccccc2)nc2cnc(N3CCOCC3)nc21 CHEMBL1520940 AC50 12.59 nM
Cc1noc(C)c1-c1cc(NC2CCNCC2)ncn1 CHEMBL1611630 Potency 12.6 nM
N#CCC(=O)NC(=O)NCC1CC1 CHEMBL1302739 Potency 12.6 nM
CC(C)[C@@H]1COC[C@H](C2(OC(=O)N3CC[C@@H](O)C3)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL1271600 IC50 13.6 nM
CC(C)[C@@H]1COC[C@H](C2(OC(=O)N3CCC(CO)CC3)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL1271601 IC50 13.8 nM
COCCCN1C(=O)COc2ccc(SC[C@H]3CNCC(=O)N3c3ccc(OCCCOCc4ccccc4OC)cc3)cc21 CHEMBL205345 IC50 14.0 nM
Cc1ccccc1[C@H](CC(=O)O)NC(=O)c1cc(OCC2CC2)n(-c2ccccc2F)n1 CHEMBL2171398 IC50 15.0 nM
CCOc1cc(C(=O)N[C@@H](CC(=O)O)c2ccccc2C)nn1-c1ccccc1F CHEMBL2171397 IC50 15.0 nM
CCc1nn(CCCN2CCN(c3cccc(Cl)c3)CC2)c(=O)n1CCOc1ccccc1 CHEMBL623 IC50 15.0 nM
CC(C)c1ccc(COc2ccc(N(CCN)C(=O)c3ccc(Cl)cc3Cl)cc2)cc1 CHEMBL4095951 IC50 15.0 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccccn5)ccc43)cc2)nn1 CHEMBL552567 IC50 15.1 nM
C/C=C/OC(=O)NC(c1ccccc1)[C@@]1(C(=O)OCC)CCCC1=O CHEMBL1601824 Potency 15.8 nM
Cc1n[nH]c2cnc(-c3cc(OC[C@@H](N)Cc4c[nH]c5ccccc45)cnc3-c3ccoc3)cc12 CHEMBL594933 IC50 16.0 nM
Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 CHEMBL104 IC50 16.0 nM
CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 CHEMBL163 IC50 16.0 nM
CC[C@@H](C)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@H]5CO[C@@](Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O CHEMBL1835953 IC50 16.0 nM
CC[C@H](C)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@H]5CO[C@@](Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O CHEMBL1835952 IC50 17.0 nM
Nc1cc(Cc2ccn(Cc3cccc(-c4ccccc4)c3)n2)c2nn[nH]c2n1 CHEMBL4863015 IC50 17.0 nM
COc1cccc(OCCCOc2ccccc2C(C)C)c1 CHEMBL1606258 AC50 17.78 nM
COc1ccccc1COCCCOc1ccc(N2C(=O)CNC[C@@H]2COc2ccc3c(c2)N(CCN(C)C(C)=O)CCC3)cc1 CHEMBL377512 IC50 18.0 nM
COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(-c2ccccn2)cc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N1CCN(Cc2ccccc2)C1=O)C(C)(C)C)C(C)(C)C CHEMBL507731 Ki 18.0 nM
Cc1cc(N2CCC(N3CCN(C(=O)N4CCOCC4)CC3)CC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL459118 IC50 19.0 nM
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)C(=O)c1ccc2nc(N)sc2c1 CHEMBL2059114 IC50 19.0 nM
CC[C@H](C)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@@H]5CO[C@](Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O CHEMBL1835954 IC50 20.0 nM
O=C(COc1ccc(-n2ccnc2)cc1)Nc1ccc(-c2ccccc2)cc1 CHEMBL4097104 IC50 20.0 nM
CCN(C)c1nc2ccc(C(=O)N(CC(C)C)C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)OCc3cccnc3)cc2o1 CHEMBL2058906 IC50 22.0 nM
CCN(C)c1nc2ccc(C(=O)N(CC(C)C)C[C@H](O)[C@H](Cc3ccccc3)NC(=O)OCc3cncs3)cc2o1 CHEMBL2058665 IC50 22.0 nM
CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@H](CC[C@H](Cc2ccccc2)NC(=O)OCc2cnc[nH]2)Cc2ccccc2)C(C)C)cs1 CHEMBL2347185 Ks 22.0 nM
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)C(=O)c1ccc2ncsc2c1 CHEMBL2059115 IC50 23.0 nM
CCN(C)c1nc2ccc(C(=O)N(CC(C)C)C[C@@H](O)[C@H](Cc3ccc(F)cc3)NC(=O)OCc3cncs3)cc2o1 CHEMBL2058900 IC50 23.0 nM
C[C@@H]1CN(Cc2ccccc2)c2cnccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3895005 IC50 23.0 nM
CC(C)(C)[C@@H]1COC[C@H](COC(=O)N2CCN(C(C)(C)CO)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL1271704 IC50 23.8 nM
CC[C@@H](C)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@@H]5CO[C@](Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O CHEMBL1835955 Ks 23.8 nM
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)C(=O)c1ccc2nc(-c3ccccc3)oc2c1 CHEMBL2058905 IC50 24.0 nM
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)C(=O)c1ccc2nc(-c3ccncc3)oc2c1 CHEMBL2058664 IC50 24.0 nM
C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO CHEMBL253144 Potency 25.1 nM
Cc1nc2cnc(N(C)C)nc2n(Cc2ccc(F)cc2)c1=O CHEMBL1411543 Potency 25.1 nM
Cn1c(=O)c(CCc2ccccc2)nc2cnc(N3CCNCC3)nc21 CHEMBL1366296 Potency 25.1 nM
CS(=O)(=O)N1CCC2(CC1)CN(C(=O)Nc1cccc(C#N)c1)C2 CHEMBL1435404 Potency 25.1 nM
CC1CCC2C(=O)N3C(CCC(C)[C@@H]3c3cccc(N4CCOCC4)c3)C(=O)N2C1c1cccc(Br)c1 CHEMBL1593751 Potency 25.1 nM
Fc1ccc(C2CC(c3ccco3)=NN2c2ccccc2)cc1 CHEMBL1589124 AC50 25.12 nM
O=C(Nc1ccc(-c2ccccc2)cc1)Nc1ccc(-c2ccnc3[nH]cnc23)cc1 CHEMBL1951331 IC50 26.0 nM
O=C(N[C@@H](Cc1ccccc1)[C@H](O)CN(CC1CCCCC1)C(=O)c1ccc2nc(N3CCCC3)oc2c1)OCc1cncs1 CHEMBL2057522 IC50 26.0 nM
CCN(C)c1nc2ccc(C(=O)N(CC3CCCCC3)C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)OCc3cncs3)cc2o1 CHEMBL2057523 IC50 26.0 nM
COc1cc(C(=O)N[C@@H](CC(=O)O)c2ccccc2C)nn1-c1ccccc1F CHEMBL2171396 IC50 26.0 nM
CC(=O)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL295698 IC50 26.9 nM
CC(C)(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)C(=O)c1ccc2nc(N3CCCC3)oc2c1 CHEMBL2057527 IC50 27.0 nM
C[C@H](c1nc2ncccc2c(=O)n1-c1ccc(O)cc1)N(Cc1cccnc1)C(=O)Cc1ccc(OC(F)(F)F)cc1 CHEMBL1939697 IC50 27.0 nM
Nc1ccc(SC[C@@H]2CO[C@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1 CHEMBL70611 Ki 28.0 nM
CCNc1nc2ccc(C(=O)N(CC(C)C)C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)OCc3cncs3)cc2o1 CHEMBL2057518 IC50 28.0 nM
COc1ccccc1CNC(=O)CN1CCC(NC(=O)c2ccccc2F)CC1 CHEMBL1464877 AC50 28.18 nM
COCO[C@H]([C@@H]1OC(C)(C)O[C@H]1CO[Si](C)(C)C(C)(C)C)[C@H](CNC(=O)c1ccccc1)c1ccc2c(c1)OCO2 CHEMBL1089299 pKi 28.84 nM
COCO[C@@H]([C@@H]1OC(C)(C)O[C@H]1CO[Si](C)(C)C(C)(C)C)[C@@H](CNC(=O)c1ccccc1)c1ccc2c(c1)OCO2 CHEMBL573430 Ki 30.0 nM
CC(C)[C@@H]1COC[C@H](C2(OC(=O)N3CC[C@H](O)C3)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL1271651 IC50 30.0 nM
CN1CCC12CCN(C(=O)OC1([C@H]3COC[C@@H](CC4CC4)N3S(=O)(=O)c3ccc(Cl)cc3)CC1)CC2 CHEMBL1272207 IC50 30.0 nM
O=C(Nc1ccc(-c2ccc(O)cc2)cc1)Nc1ccc(-c2ccnc3[nH]cnc23)cc1 CHEMBL1951445 IC50 30.0 nM
O=C(N[C@@H](Cc1ccccc1)[C@H](O)CN(CC1CCC(F)(F)CC1)C(=O)c1ccc2nc(N3CCCC3)oc2c1)OCc1cncs1 CHEMBL2057791 IC50 30.0 nM
C#CCN(C)c1nc2ccc(C(=O)N(CC(C)C)C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)OCc3cncs3)cc2o1 CHEMBL2057792 IC50 30.0 nM
O=C(N[C@H](Cc1cccc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 CHEMBL2059798 IC50 30.0 nM
O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 CHEMBL2059799 IC50 30.0 nM
COCC(=O)N[C@@H](Cc1ccc(-c2nccs2)cc1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181898 IC50 30.0 nM
CC#Cc1cccc(C[C@H](NC(=O)COC)[C@H](O)CN[C@H]2CC3(CCC3)Oc3ncc(CC(C)(C)C)cc32)c1 CHEMBL2181897 IC50 30.0 nM
C#Cc1cccc(C[C@H](NC(=O)COC)[C@H](O)CN[C@H]2CC3(CCC3)Oc3ncc(CC(C)(C)C)cc32)c1 CHEMBL2181896 IC50 30.0 nM
COCC(=O)N[C@@H](Cc1cccc(-c2cncs2)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181893 IC50 30.0 nM
NC(=O)c1cncc(Oc2c(Cl)cc(NS(=O)(=O)c3ccc(Cl)cc3Cl)cc2Cl)c1 CHEMBL2338481 IC50 30.0 nM
Cc1cn(-c2cc3c(cc2F)Nc2nc(Cc4ccccc4)ccc2C(=O)N3)cn1 CHEMBL3771295 IC50 30.0 nM
Nc1ccc(C(=O)/C=C/c2ccc3ncccc3c2)cc1 CHEMBL5422931 Ki 30.0 nM
CCN(C)c1nc2ccc(C(=O)N(CC(C)C)C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)OCc3cncs3)cc2o1 CHEMBL2058910 IC50 31.0 nM
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)C(=O)c1ccc2nc(NCCCn3ccnc3)oc2c1 CHEMBL2057790 IC50 31.0 nM
CCc1ccc([C@@H](C(=O)Nc2cc(C3(CC(=O)O)CC3)ccc2F)[C@@H](C)C(F)(F)F)cc1 CHEMBL4846000 Activity 31.0 nM
N[C@H](C(=O)O)[C@H](O)C(=O)O CHEMBL1231330 Potency 31.6 nM
COc1cc([C@H](O)CO)ccc1O CHEMBL1553353 Potency 31.6 nM
COC(=O)NC(c1cccc(C)c1)[C@]1(C(C)=O)CCOC1=O CHEMBL1483716 Potency 31.6 nM
C/C=C/OC(=O)NC(c1ccccc1)[C@]1(C(C)=O)CCOC1=O CHEMBL1574543 Potency 31.6 nM
C[C@]12Cc3cn4c(nc3C=C1CC[C@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@]2(O)C#N)nc1ccccc14 CHEMBL1320743 Potency 31.6 nM
Nc1ccc(N(S(=O)(=O)c2ccccc2)S(=O)(=O)c2ccccc2)c(Cl)c1 CHEMBL1358449 Potency 31.6 nM
NCC(CC(=O)O)c1ccc(Cl)cc1 CHEMBL701 Potency 31.6 nM
CN(C)c1ccc(-c2cncnc2NCc2ccccc2)cc1 CHEMBL1516232 AC50 31.62 nM
CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O CHEMBL64391 IC50 32.6 nM
Nc1ccc(SC[C@H]2CO[C@@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1 CHEMBL305220 Ki 33.0 nM
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)C(=O)c1ccc2nc(N3CCCC3)oc2c1 CHEMBL2059117 IC50 33.0 nM
CCc1cccc(-c2c(Cl)cccc2C(O)(CCCNC(=O)OC)[C@@H]2CCCN(C(=O)[C@@H]3CC[C@H](N)C3)C2)c1 CHEMBL4214937 IC50 34.0 nM
COCCCN1C(=O)CCc2ccc(OC[C@H]3CNCC(=O)N3c3ccc(OCCCOCc4ccccc4OC)cc3)cc21 CHEMBL193816 IC50 35.0 nM
COc1cccc(N2C(=O)N(Cc3ccccc3F)C3(CCN(Cc4ccc(-n5ccnc5)cc4)CC3)C2=O)c1 CHEMBL230080 IC50 35.0 nM
COc1ccc(C(NC(=O)c2ccc(-c3ccccc3)cc2)c2ccccc2)cc1 CHEMBL1346170 AC50 35.48 nM
Cc1ccc(C(=O)N2CCN(C3c4cccc5cccc(c45)C3NS(=O)(=O)c3ccccc3)CC2)cc1 CHEMBL1362504 AC50 35.48 nM
O=C(C1CCC(=O)N1Cc1ccccc1Cl)N1CCN(c2cccc(Cl)c2)CC1 CHEMBL1454735 AC50 35.48 nM
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)C(=O)c1ccc2nc(C(C)C)oc2c1 CHEMBL2058663 IC50 37.0 nM
CCN(C)c1nc2ccc(C(=O)N(C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)OCc3cncs3)CC(C)(C)C)cc2o1 CHEMBL2057788 IC50 37.0 nM
Nc1cc(Cc2ccn(Cc3cccc(Cc4ccccc4)c3)n2)c2nn[nH]c2n1 CHEMBL4878518 IC50 37.0 nM
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)C(=O)c1ccc2nc(N3CCOCC3)oc2c1 CHEMBL2059120 IC50 38.0 nM
C#CCNc1nc2ccc(C(=O)N(CC#C)C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)OCc3cncs3)cc2o1 CHEMBL2057787 IC50 38.0 nM
Cc1ccccc1[C@H](CC(=O)O)NC(=O)c1cc(=O)n(-c2ccccc2F)[nH]1 CHEMBL3145341 IC50 38.0 nM
CCc1nc2ccc(C(=O)N(CC(C)C)C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)OCc3cncs3)cc2o1 CHEMBL2057786 IC50 39.0 nM
Clc1cccc(N2CCNCC2)c1 CHEMBL478 Potency 39.8 nM
Nc1ncnc2c1ncn2C1CCCC1 CHEMBL1416619 Potency 39.8 nM
c1ccc2nc(N3CCNCC3)ccc2c1 CHEMBL18772 Potency 39.8 nM
N=C(N)NOCCC(N)C(=O)O CHEMBL182461 Potency 39.8 nM
CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@@H](N)c3ccccc3)[C@@H]2SC1 CHEMBL1496979 Potency 39.8 nM
O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1 CHEMBL15023 Potency 39.8 nM
Cc1c(Cl)cccc1NC(=O)c1ccc(-n2ccnc2)nc1 CHEMBL1522673 AC50 39.81 nM
Cn1c(=O)n(C)c2cc(/C=N/NC(=O)c3ccc(Cl)cc3Cl)ccc21 CHEMBL3195510 AC50 39.81 nM
CC(NC(=O)CCSc1nc(-c2ccc3c(c2)OCO3)cc(C(F)(F)F)n1)c1ccccc1 CHEMBL1353351 AC50 39.81 nM
CC(C)(c1ncc(-c2cnccc2Cl)o1)N1CCN(C[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3OC[C@H]2O)[C@H](C(=O)NCC(F)(F)F)C1 CHEMBL3706622 IC50 40.0 nM
COc1cncc(-c2cnc(C(C)(C)N3CCN(C[C@@H](O)C[C@@H](Cc4ccccc4)C(=O)N[C@H]4c5ccccc5OC[C@H]4O)[C@H](C(=O)NCC(F)(F)F)C3)o2)c1 CHEMBL3706615 IC50 40.0 nM
CC(C(c1ccc2cc(OCc3ccc(OC(C)(C)C)cc3)ccc2c1)n1ccnc1)N(C)C CHEMBL181385 IC50 40.0 nM
Cc1cc(N2CCC(N3CCN(C(=O)N4CCN(C)CC4)CC3)CC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL454515 IC50 40.0 nM
O=C(NC1CCN(Cc2ccn(-c3ccc(C(F)(F)F)cc3)c2)CC1)NC(Cn1ccnc1)c1ccccc1 CHEMBL557263 IC50 40.0 nM
Oc1cccc(-c2ccc3c(-c4cccc(O)c4)c(O)ccc3c2)c1 CHEMBL1650652 IC50 40.0 nM
CS(=O)(=O)N(CCN1CCOCC1)c1ccc(Nc2ncc3cnn(C4CCCCCC4)c3n2)cc1 CHEMBL1825089 IC50 40.0 nM
C#CCN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)C(=O)c1ccc2nc(N3CCCC3)oc2c1 CHEMBL2057524 IC50 40.0 nM
COc1c(C2CC2c2ccc(NS(C)(=O)=O)cc2)cc(-c2ccc[nH]c2=O)cc1C(C)(C)C CHEMBL2431463 IC50 40.0 nM
CC1Cc2cc(F)ccc2N1C(=O)Cc1nc(N2CCOCC2)sc1C(N)=O CHEMBL3125375 IC50 40.0 nM
COc1nc(-c2csc(Nc3cc(C(C)(C)C)nn3CCF)n2)ccc1-n1cnc(C)c1 CHEMBL4786740 IC50 40.0 nM
Nc1cc(Cc2ccn(Cc3ccc4ccccc4c3)n2)c2nn[nH]c2n1 CHEMBL4853722 IC50 40.0 nM
CNc1nc2ccc(C(=O)N(CC(C)C)C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)OCc3cncs3)cc2o1 CHEMBL2057517 IC50 41.0 nM
COc1ccccc1COCCCOc1ccc(N2C(=O)CNC[C@@H]2COc2ccc3c(c2)N(CCN2CCCC2=O)CCC3)cc1 CHEMBL380866 IC50 42.0 nM
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)C(=O)c1ccc2nc(N)oc2c1 CHEMBL2058901 IC50 42.0 nM
CC(C)OC(=O)[C@H](Cn1ccnc1)NC(=O)c1ccc(-c2ccccc2)cc1F CHEMBL4514676 IC50 42.9 nM
Nc1ccc(C(=O)/C=C/c2ccc3nccnc3c2)cc1 CHEMBL5428544 IC50 43.51 nM
CCOC(=O)c1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]cnc34)cc2)c1 CHEMBL1951332 IC50 44.0 nM
CCN(C)c1nc2ccc(C(=O)N(CC(C)C)C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)OCc3ccc4c(c3)OCO4)cc2o1 CHEMBL2058903 IC50 44.0 nM
C=C[C@]1(C)C[C@@H](OC(=O)CSc2cncc(N)c2)[C@]2(C)[C@H](C)CC[C@]3(CCC(=O)[C@H]32)[C@@H](C)[C@@H]1O CHEMBL3291127 IC50 44.4 nM
COc1ccc(CCCOC(Cn2ccnc2)c2ccc(OC)cc2)cc1 CHEMBL258502 IC50 45.0 nM
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O CHEMBL386630 IC50 45.1 nM
C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL1471 IC50 46.0 nM
CCN(CC)C(=O)c1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]cnc34)cc2)c1 CHEMBL1951338 IC50 47.0 nM
N[C@@H](Cn1c(=O)c(-c2ccc(COC(=O)C3CC3)cc2)cn(Cc2c(F)cccc2C(F)(F)F)c1=O)c1ccccc1 CHEMBL508435 IC50 48.0 nM
COc1cccc(-c2ccc(NC(=O)Nc3ccc(-c4ccnc5[nH]cnc45)cc3)cc2)c1 CHEMBL1951447 IC50 48.0 nM
O=C(N[C@@H](Cc1ccccc1)CN(Cc1ccncc1)C[C@H](Cc1ccccc1)NC(=O)OCc1nccs1)OCc1cncs1 CHEMBL1077939 IC50 49.0 nM
CCc1cccc(-c2c(Cl)cccc2C(O)(CCCNC(=O)OC)[C@@H]2CCCN(C(=O)[C@@H]3CC[C@H](NC)C3)C2)c1 CHEMBL4207673 IC50 49.0 nM
O=C(N[C@H]1c2ccccc2OC[C@H]1O)[C@H](Cc1cccnc1)C[C@H](O)CN1CCN(Cc2ccn(-c3ccc(F)c(F)c3F)c2)C[C@H]1C(=O)NCC(F)(F)F CHEMBL334379 IC50 50.0 nM
O=C(N[C@H]1c2ccccc2OC[C@H]1O)[C@H](Cc1cccnc1)C[C@H](O)CN1CCN(Cc2ccn(-c3ccc(Cl)cc3)c2)C[C@H]1C(=O)NCC(F)(F)F CHEMBL127589 IC50 50.0 nM
Cc1[nH]nc2ccc(-c3cc(OC[C@@H](N)Cc4c[nH]c5ccccc45)cnc3-c3ccoc3)cc12 CHEMBL593490 IC50 50.0 nM
CC(C)CCN(C[C@@H](Cc1ccccc1)NC(=O)OCc1cncs1)C[C@@H](Cc1ccccc1)NC(=O)OCc1nccs1 CHEMBL1077933 IC50 50.0 nM
COc1cccc(CN(C[C@@H](Cc2ccccc2)NC(=O)OCc2nccs2)C[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)c1 CHEMBL1077937 IC50 50.0 nM
CCOC(=O)c1sc2cnccc2c1Nc1ccc2c(c1)CC/C2=N/O CHEMBL1668909 IC50 50.0 nM
Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 CHEMBL808 IC50 50.0 nM
CO[C@H](C)C(=O)N[C@@H](Cc1ccc2c(c1)OCO2)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181880 IC50 50.0 nM
COCC(=O)N[C@@H](Cc1cccc(-c2nccn2C)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181891 IC50 50.0 nM
CC(=O)Nc1nc2ccc(-c3ccc(N)nc3)cc2s1 CHEMBL2418946 IC50 50.0 nM
CC[C@@H]([C@H](C)O)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@@H]5CO[C@@](Cn6cncn6)(c6ccc(F)cc6F)C5)cc4)CC3)cc2)c1=O CHEMBL1397 IC50 50.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CCC1)C2c1ccc(Sc2nc3cccc(Cl)c3[nH]2)o1 CHEMBL3393479 IC50 50.0 nM
COc1cncc(NC(C(=O)c2c[nH]c3ccccc23)c2ccccc2)c1 CHEMBL4205724 IC50 50.0 nM
Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2 CHEMBL25856 Potency 50.1 nM
COc1cc(/C=C/C(=O)N2CCC=CC2=O)cc(OC)c1OC CHEMBL465843 Potency 50.1 nM
N#CCCCl CHEMBL1451739 Potency 50.1 nM
COc1ccc(-c2nc3cnc(OC)nc3n(C3CC3)c2=O)cc1 CHEMBL1515945 Potency 50.1 nM
Clc1cc(Cl)c(Cl)c(Cl)c1Cl CHEMBL44628 Potency 50.1 nM
Cc1ccc2c(c1)N[C@H](c1ccc(C(=O)O)cc1)c1cccn1-2 CHEMBL1321552 Potency 50.1 nM
CC(COc1ccccc1)N(CCCl)Cc1ccccc1 CHEMBL1200787 Potency 50.1 nM
Cc1ccc(NC(=O)N/C=C/c2ccc(Cl)cc2)cc1 CHEMBL1313747 AC50 50.12 nM
Cc1cccc(C)c1NC(=O)c1cc2c(=O)c3ccccc3oc2nc1C(F)(F)F CHEMBL1494612 AC50 50.12 nM
Nc1ccc(C(=O)/C=C/c2ccc3ccccc3c2)cc1 CHEMBL5440261 IC50 51.57 nM
O=C(N[C@@H](Cc1ccccc1)CN(CC1CC1)C[C@H](Cc1ccccc1)NC(=O)OCc1nccs1)OCc1cncs1 CHEMBL1077932 IC50 52.0 nM
Cc1nc2ccc(C(=O)N(CC(C)C)C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)OCc3cncs3)cc2o1 CHEMBL2058904 IC50 52.0 nM
O=C(Nc1ccc(-c2ccnc3[nH]cnc23)cc1)Nc1cccc(C(=O)Nc2ccccc2)c1 CHEMBL1951340 IC50 53.0 nM
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)C(=O)c1ccc2nc(N(C)C)oc2c1 CHEMBL2059119 IC50 53.0 nM
COc1ccccc1COCCCOc1ccc(N2C(=O)CNC[C@@H]2COc2ccc3c(c2)N(CCOC(=O)C(C)C)CCC3)cc1 CHEMBL208112 IC50 54.0 nM
COc1cc(C[C@@H](CO)[C@H](CO)Cc2ccc3c(c2)OCO3)cc(OC)c1OC CHEMBL469916 KI 54.0 nM
CCNC(=O)c1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]cnc34)cc2)c1 CHEMBL1951335 IC50 55.0 nM
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)C(=O)c1ccc2ncoc2c1 CHEMBL2057528 IC50 55.0 nM
CC(C)(C)OC(=O)NC(CSCC(Nc1ccccc1)C(=O)NCc1cccnc1)Cc1cccc2ccccc12 CHEMBL4632678 IC50 55.0 nM
Cc1c(C)n(C[C@H]2C[C@@H]2C)c2c(OCc3ccc(F)cc3)nncc12 CHEMBL1087758 pIC50 56.23 nM
CCS(=O)(=O)N1CCC(C(=O)NCCCOC)CC1 CHEMBL1742000 AC50 56.23 nM
CCCC(=O)NNC(=O)CCC(=O)NCc1ccccc1 CHEMBL1549242 AC50 56.23 nM
c1cncc(CNCc2ccc(CN(C[C@H]3Cc4ccccc4CN3)[C@H]3CCCc4cccnc43)cc2)c1 CHEMBL4099550 IC50 58.0 nM
c1ccc2c(c1)CN[C@@H](CN(Cc1ccc(CNCc3ccncc3)cc1)[C@H]1CCCc3cccnc31)C2 CHEMBL4083122 IC50 59.0 nM
Cc1cc(-n2ccnc2)cc2[nH]c(-c3c(N[C@H](CO)Cc4ccccc4)cc[nH]c3=O)nc12 CHEMBL230204 IC50 60.0 nM
O=C(OC1([C@H]2CCC[C@@H](c3cc(F)cc(F)c3)N2S(=O)(=O)c2ccc(Cl)cc2)CC1)N1CCN(CCO)CC1 CHEMBL239629 IC50 60.0 nM
Clc1ccc(OC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 CHEMBL270902 IC50 60.0 nM
O=C(N[C@H](Cc1ccccc1)CN(Cc1ccccc1)C[C@@H](Cc1ccccc1)NC(=O)OCc1nccs1)OCc1cncs1 CHEMBL1077936 IC50 60.0 nM
CC(C)N(C(=O)c1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]cnc34)cc2)c1)C(C)C CHEMBL1951339 IC50 60.0 nM
CCN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)C(=O)c1ccc2nc(N3CCCC3)oc2c1 CHEMBL2057521 IC50 60.0 nM
CC(C)[C@H](NC(=O)c1ccc2[nH]nc(-c3ccc(N4C5CCC4COC5)cc3)c2c1)c1ccccc1Cl CHEMBL3422083 IC50 60.0 nM
Nc1cc(OCc2cc(-c3cccc(F)c3)ccc2Cl)c2nn[nH]c2n1 CHEMBL4582838 IC50 60.0 nM
O=C(Cc1ccc(F)cc1)N1CCC(C(O)CC2c3ccccc3-c3cncn32)CC1 CHEMBL4542242 IC50 60.0 nM
O=C(Nc1ccc(-c2ccnc3[nH]cnc23)cc1)Nc1cccc([N+](=O)[O-])c1 CHEMBL1951328 IC50 61.0 nM
Cc1ncc2n1-c1ccc(Cl)cc1C(c1ccccc1F)=NC2 CHEMBL655 IC50 61.8 nM
CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)NC4(c5cccnc5)CC4)ccc3C)cc12 CHEMBL4096241 IC50 63.0 nM
O=C(CCBr)N1CCN(C(=O)CCBr)CC1 CHEMBL1585 Potency 63.1 nM
NC(=O)CI CHEMBL276727 Potency 63.1 nM
CC(=O)N1CCN(c2ccc(OCC3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL1324508 Potency 63.1 nM
CN(C)c1ccc(-c2cc(-n3ccnc3)ncn2)cc1 CHEMBL1331363 Potency 63.1 nM
COc1cccc2c1cc([N+](=O)[O-])c1c(C(=O)O)cc3c(c12)OCO3 CHEMBL93353 Potency 63.1 nM
Nc1ccc(-c2nc3ccc(-c4nc5ccc(N)cc5[nH]4)cc3[nH]2)cc1 CHEMBL578741 Potency 63.1 nM
Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 CHEMBL1201049 Potency 63.1 nM
Cn1nnnc1SCC1=C(C(=O)[O-])N2C(=O)C(NC(=O)C(O)c3ccccc3)C2SC1 CHEMBL1485048 Potency 63.1 nM
O=c1ccc2ccc(COC(Cn3ccnc3)c3ccc(Cl)cc3Cl)cc2o1 CHEMBL5423031 IC50 64.0 nM
O=C(NC(Cc1ccccc1)CN(CC(Cc1ccccc1)NC(=O)OCc1cncs1)CC(Cc1ccccc1)NC(=O)OCc1nccs1)OCc1cncs1 CHEMBL1079228 IC50 65.0 nM
O=C(Nc1ccc(S(=O)(=O)c2cccc(OC(F)(F)F)c2)cc1)[C@@H]1C[C@H]1c1cccnc1 CHEMBL3127501 IC50 65.0 nM
COC(=O)N[C@H](C(=O)N[C@H](Cc1ccc(-c2ccccn2)cc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N1CCN(Cc2cccc(C(C)(C)O)n2)C1=O)C(C)(C)C)C(C)(C)C CHEMBL470508 Ki 66.0 nM
O=C(N[C@@H](Cc1ccccc1)CN(Cc1cccnc1)C[C@H](Cc1ccccc1)NC(=O)OCc1nccs1)OCc1cncs1 CHEMBL1077938 IC50 66.0 nM
O=C(N[C@@H](Cc1ccccc1)CN(Cc1c[nH]cn1)C[C@H](Cc1ccccc1)NC(=O)OCc1nccs1)OCc1cncs1 CHEMBL1077940 IC50 66.0 nM
CCN(CC(CC1CCCCC1)NC(=O)OCc1cncs1)CC(CC1CCCCC1)NC(=O)OCc1nccs1 CHEMBL1081515 IC50 66.0 nM
CC(C)CN(C[C@@H](Cc1ccccc1)NC(=O)OCc1cncs1)C[C@@H](Cc1ccccc1)NC(=O)OCc1nccs1 CHEMBL1077931 IC50 67.0 nM
CCN(C)c1nc2ccc(C(=O)N(CC(C)C)C[C@H](O)[C@H](Cc3cccnc3)NC(=O)OCc3cncs3)cc2o1 CHEMBL2057794 IC50 69.0 nM
COCO[C@H]([C@@H]1OC(C)(C)O[C@H]1COS(=O)(=O)c1ccc(C)cc1)[C@H](CNC(=O)c1ccccc1)c1ccc2c(c1)OCO2 CHEMBL1089957 pKi 69.18 nM
COCO[C@@H]([C@@H]1OC(C)(C)O[C@H]1COS(=O)(=O)c1ccc(C)cc1)[C@@H](CNC(=O)c1ccccc1)c1ccc2c(c1)OCO2 CHEMBL573665 Ki 70.0 nM
O=C(N[C@H](Cc1ccccc1)CN(Cc1cnc2ccccc2c1)C[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)OCc1nccs1 CHEMBL1077941 IC50 70.0 nM
Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 CHEMBL1221 IC50 70.0 nM
O=C(Nc1ccc(-c2ccnc3[nH]cnc23)cc1)Nc1cccc(C(=O)NC2CCCC2)c1 CHEMBL1951341 IC50 70.0 nM
NCCN(C(=O)c1ccc(Cl)cc1Cl)c1ccc(Cl)cc1 CHEMBL4097622 IC50 70.0 nM
COc1ccc(C(=O)/C=C/c2ccc3cnccc3c2)c(OC)c1 CHEMBL5411496 IC50 70.03 nM
Cc1cnc(CNc2cc(-c3ccccc3)nc(-c3ccncc3)n2)nc1 CHEMBL271121 IC50 71.0 nM
CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)NC4(c5ccncc5)CC4)ccc3C)cc12 CHEMBL4086080 IC50 73.0 nM
NCCN(C(=O)c1ccc(Cl)cc1Cl)c1ccc(F)cc1 CHEMBL4070447 IC50 74.0 nM
CC(C)(C)OC(=O)N[C@H](CS[C@H](Cc1ccccc1)C(=O)NCCc1cccnc1)Cc1cccc2ccccc12 CHEMBL4640859 IC50 75.0 nM
Nc1ccc(C(=O)/C=C/c2ccc3cnccc3c2)cc1 CHEMBL5397192 IC50 75.87 nM
Nc1noc2ccc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)cc3F)cc12 CHEMBL3341983 IC50 77.0 nM
COc1ccc(C(=O)/C=C/c2ccc3cnccc3c2)cc1 CHEMBL5396316 IC50 77.59 nM
O=C(Nc1ccc(-c2ccnc3[nH]cnc23)cc1)Nc1cccc(C(=O)N2CCCCC2)c1 CHEMBL1951342 IC50 79.0 nM
CCN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)C(=O)c1ccc2nc(N(C)CC)oc2c1 CHEMBL2057520 IC50 79.0 nM
CC(C)NC(=O)N1CC2(CCN(C(=O)c3ccncc3)CC2)C1 CHEMBL1395338 Potency 79.4 nM
C=CCOC(=O)C(C(C)=O)C(NC(=O)OC)c1cccc(F)c1 CHEMBL1435727 Potency 79.4 nM
O=c1c(CCc2ccccc2)nc2cnc(Oc3ccccc3)nc2n1C[C@H]1CCCO1 CHEMBL1475924 Potency 79.4 nM
Cc1cccc(CNc2ncncc2-c2ccccc2C(F)(F)F)c1 CHEMBL491909 Potency 79.4 nM
COc1ccccc1CNc1ncncc1-c1ccccc1C(F)(F)F CHEMBL491910 Potency 79.4 nM
S=C(NC1CCCCC1)N1CCC(c2cnc[nH]2)CC1 CHEMBL260374 Potency 79.4 nM
CCCC[C@@H]1C[C@H]1C(NC(=O)c1cccnc1)c1ccc(Cl)cc1 CHEMBL1557564 Potency 79.4 nM
c1cc2c(cc1C1OC[C@@H]3C(c4ccc5c(c4)OCO5)OCC13)OCO2 CHEMBL1591714 Potency 79.4 nM
Cc1ccc(Nc2ccc(-n3ccnc3)nn2)cc1C CHEMBL1484866 AC50 79.43 nM
O=C(N[C@H]1c2ccccc2OC[C@H]1O)[C@H](Cc1cccnc1)C[C@H](O)CN1CCN(Cc2ccn(-c3cccc(Cl)c3)c2)C[C@H]1C(=O)NCC(F)(F)F CHEMBL276081 IC50 80.0 nM
N#Cc1ccccc1Cn1c(N2CCC[C@@H](N)C2)nc2c(Cl)cc(Cl)cc2c1=O CHEMBL390529 IC50 80.0 nM
Cc1cc(-n2ccnc2)cc2nc(-c3c(NCc4ccccn4)cc[nH]c3=O)[nH]c12 CHEMBL397666 IC50 80.0 nM
O=c1c(-c2c(O)cc(O)c3c(=O)cc(-c4ccc(O)cc4)oc23)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12 CHEMBL515252 IC50 80.0 nM
CN1CCN(C(=O)c2cn(Cc3cncn3Cc3ccc4c(c3)OCO4)cc2-c2cccc3ccccc23)CC1 CHEMBL105592 Ki 80.0 nM
CC(C)(C)n1nnnc1C(NCCNc1ccnc2cc(Cl)ccc12)c1ccc(Cl)cc1 CHEMBL2414256 IC50 80.0 nM
O=C(N[C@@H](CC[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)N(Cc1cncs1)C1CC1)Cc1ccccc1)OCc1cncs1 CHEMBL3115190 IC50 80.0 nM
CC(C)[C@H](NC(=O)N(C)Cc1cncs1)C(=O)N[C@H](CC[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)Cc1ccccc1 CHEMBL3115165 IC50 80.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CCC1)C2c1ccc(Sc2nc3c(N)cccc3[nH]2)o1 CHEMBL3393483 IC50 80.0 nM
CCOc1cccc(CNC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL4454552 IC50 80.0 nM
CCCOc1cccc(CNC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL4476761 IC50 80.0 nM
O=C(NCc1cccc2c1OCCO2)c1ccc(-c2ccncc2)cc1 CHEMBL4522042 IC50 80.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL4448806 IC50 80.0 nM
COc1ccccc1COCCCOc1ccc(N2C(=O)CNC[C@@H]2COc2ccc3c(c2)N(CCNC(C)=O)CCC3)cc1 CHEMBL411885 IC50 82.0 nM
COc1cc(C[C@H]2C(O)OC[C@@H]2Cc2ccc3c(c2)OCO3)cc(OC)c1OC CHEMBL479701 KI 82.0 nM
COC(=O)c1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]cnc34)cc2)c1 CHEMBL1951329 IC50 82.0 nM
COc1cc(O)c(C(=O)/C=C/c2ccc3cnccc3c2)c(OC)c1 CHEMBL5403485 IC50 83.56 nM
O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 CHEMBL466555 IC50 84.0 nM
CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)C(=O)c1ccc2nc(N3CCCC3)oc2c1 CHEMBL2057514 IC50 84.0 nM
O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 CHEMBL2059880 IC50 84.0 nM
CC(C)(C)OC(=O)N[C@@H](CSCC(Nc1ccccc1)C(=O)NCc1cccnc1)Cc1c[nH]c2ccccc12 CHEMBL4644850 IC50 85.0 nM
O=C(N[C@H](Cc1ccccc1)CN(Cc1ccccc1)C[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)OCc1nccs1 CHEMBL1077935 IC50 87.0 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(-c3ccncc3)cc2C2=CCCCC2)n1 CHEMBL1172346 IC50 87.0 nM
CC(C)CC1n2cncc2CN(Cc2ccc(Cl)cc2)S1(=O)=O CHEMBL1209553 IC50 87.0 nM
O=S(=O)(c1cccs1)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3960724 IC50 87.0 nM
CCN(CC(CC(=O)OC)NC(=O)OCc1cncs1)CC(CC(=O)OC)NC(=O)OCc1nccs1 CHEMBL1081514 IC50 88.0 nM
O=C(N[C@H](CNC[C@@H](Cc1ccccc1)NC(=O)OCc1nccs1)Cc1ccccc1)OCc1cncs1 CHEMBL1079896 IC50 90.0 nM
CC(C)CN(C[C@@H](Cc1ccccc1)NC(=O)OCc1nccs1)C[C@H](Cc1ccccc1)NC(=O)OCc1cncs1 CHEMBL1077930 IC50 90.0 nM
Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 CHEMBL1262 IC50 90.0 nM
CC(C)NC(=O)c1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]cnc34)cc2)c1 CHEMBL1951336 IC50 90.0 nM
CC(C)CN(C[C@@H](O)[C@H](Cc1cccnc1)NC(=O)OCc1cncs1)C(=O)c1ccc2ncsc2c1 CHEMBL2059116 IC50 90.0 nM
CC(C)c1nc(CN(C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CC[C@@H](Cc2ccccc2)NC(=O)OCc2cncs2)Cc2ccccc2)cs1 CHEMBL3115191 IC50 90.0 nM
O=C(Nc1ccc(S(=O)(=O)c2ccccc2)cc1)[C@H]1C[C@@H]1c1cccnc1 CHEMBL3127521 IC50 90.0 nM
O=S(=O)(Nc1ncns1)c1cc(F)c(OCC[C@]2(c3ccccc3)CC[C@H](NC3CC3)CC2)cc1F CHEMBL4063378 IC50 90.0 nM
CCc1cccc(-c2c(F)cccc2C(O)(CCCNC(=O)OC)[C@@H]2CCCN(C(=O)[C@@H]3CC[C@H](N)C3)C2)c1 CHEMBL4204601 IC50 90.0 nM
Clc1ccc2c(N3CCN(CCCN4CCN(c5ccnc6cc(Cl)ccc56)CC4)CC3)ccnc2c1 CHEMBL303933 Ki 90.0 nM
C[C@]12CCC(=O)C[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](c3ccc(=O)oc3)CC[C@]12O CHEMBL2068968 IC50 90.0 nM
COc1cccc(C(=O)/C=C/c2ccc3cnccc3c2)c1 CHEMBL5425736 IC50 90.0 nM
CCC(c1ccc(-c2ccc(O)c(Cl)c2)cc1)n1ccnc1 CHEMBL541941 IC50 91.0 nM
CCN(CC(Cc1ccc(O)cc1)NC(=O)OCc1cncs1)CC(Cc1ccc(O)cc1)NC(=O)OCc1nccs1 CHEMBL1078122 IC50 91.0 nM
O=C(Nc1ccc(-c2ccnc3[nH]cnc23)cc1)Nc1cccc(Br)c1 CHEMBL1951325 IC50 92.0 nM
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)C(=O)c1ccc2nc(N3CCN(C)CC3)oc2c1 CHEMBL2059123 IC50 92.0 nM
COc1ccc(C(=O)/C=C/c2ccc3cnccc3c2)cc1OC CHEMBL5408831 IC50 94.11 nM
Cc1cc2c(F)c(Oc3ncnn4cc(OC[C@@H](C)OC(=O)[C@H](N)CC(C)C)c(C)c34)ccc2[nH]1 CHEMBL408443 IC50 95.0 nM
CCNc1nc2ccc(C(=O)N(C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)OCc3cncs3)CC(C)(C)O)cc2o1 CHEMBL2057789 IC50 97.0 nM
CNC(=O)c1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]cnc34)cc2)c1 CHEMBL1951334 IC50 98.0 nM
O=C(N[C@@H](CNC[C@@H](Cc1ccccc1)NC(=O)OCc1nccs1)Cc1ccccc1)OCc1cncs1 CHEMBL1079897 IC50 99.0 nM
O=S(=O)(C(F)F)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 CHEMBL3968178 IC50 99.0 nM