Cc1cnc2cc(C(F)(F)F)ccc2c1N1CC[C@H](C(=O)N2CCn3c(nnc3C(F)(F)F)C2)[C@H](C)C1 CHEMBL4436614 IC50 0.17 nM
COc1ccc2c(N3CC[C@H](C(=O)N4CCn5c(nnc5C(F)(F)F)C4)[C@H](C)C3)c(Cl)cnc2c1 CHEMBL4453090 IC50 0.2 nM
C[C@@H]1CN(c2c(Cl)cnc3cc(-c4ncco4)ccc23)CC[C@@H]1C(=O)N1CCc2c(noc2C(F)(F)F)C1 CHEMBL4469186 IC50 0.2 nM
C[C@@H]1CN(c2c(Cl)cnc3cc(C(F)(F)F)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4455566 IC50 0.2 nM
COc1ccc2c(N3CC[C@H](C(=O)N4CCn5c(nnc5C(F)(F)F)C4)[C@H](C)C3)c([N+](=O)[O-])cnc2c1 CHEMBL4566069 IC50 0.2 nM
C[C@@H]1CN(c2c(Cl)cnc3cc(OCC4CC4)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4445397 IC50 0.22 nM
C[C@@H]1CN(c2c(Cl)cnc3cc(C4CC4)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4459136 IC50 0.25 nM
C[C@@H]1CN(c2c(F)cnc3cc(C(F)(F)F)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4580955 IC50 0.25 nM
CC(=O)c1ccc2c(N3CC[C@H](C(=O)N4CCn5c(nnc5C(F)(F)F)C4)[C@H](C)C3)c(Cl)cnc2c1 CHEMBL4452352 IC50 0.28 nM
Cc1cnc2cc(C(C)(F)F)ccc2c1N1CC[C@H](C(=O)N2CCn3c(nnc3C(F)(F)F)C2)[C@H](C)C1 CHEMBL4450590 IC50 0.31 nM
C[C@@H]1CN(c2c(Cl)cnc3cc(C(F)F)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4588702 IC50 0.32 nM
CC(O)c1ccc2c(N3CC[C@H](C(=O)N4CCn5c(nnc5C(F)(F)F)C4)[C@H](C)C3)c(Cl)cnc2c1 CHEMBL4452739 IC50 0.34 nM
C[C@@H]1CN(c2ccnc3cc(OC(F)(F)F)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4435552 IC50 0.34 nM
C[C@@H]1CN(c2c(Cl)cnc3cc(OC(F)(F)F)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4440278 IC50 0.35 nM
COc1ccc2c(N3CC[C@H](C(=O)N4CCn5c(nnc5C(F)(F)F)C4)[C@H](C)C3)c(Cl)cnc2c1F CHEMBL4515054 IC50 0.38 nM
C[C@@H]1CN(c2ccnc3cc(-c4ccccc4)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4576569 IC50 0.4 nM
C[C@@H]1CN(c2ccnc3cc(-c4ncco4)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4565048 IC50 0.4 nM
C[C@@H]1CN(c2c(Cl)cnc3c2CCN(c2ccccn2)C3)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4462103 IC50 0.4 nM
C[C@@H]1CN(c2c(Cl)cnc3cc(Br)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4568439 IC50 0.44 nM
C[C@@H]1CN(c2c(F)cnc3cc(C(F)F)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4517730 IC50 0.46 nM
C[C@@H]1CN(c2c(Cl)cnc3cc(C(C)(F)F)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4461071 IC50 0.46 nM
C[C@@H]1CN(c2c(Cl)cnc3cc(-c4ncco4)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C2CC2)C1 CHEMBL4438730 IC50 0.5 nM
C[C@@H]1CN(c2c(F)cnc3cc(C(C)(F)F)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4580260 IC50 0.57 nM
C[C@@H]1CN(c2c(Cl)cnc3cc(F)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4538016 IC50 0.6 nM
C[C@@H]1CN(c2c(C(F)F)cnc3cc(C4CC4)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4468107 IC50 0.61 nM
C[C@@H]1CN(c2ccnc3cc(C4CC4)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4555467 IC50 0.66 nM
COc1ccc2c(N3CC[C@H](C(=O)N4CCn5c(nnc5C(F)(F)F)C4)[C@H](C)C3)c(C3CC3)cnc2c1 CHEMBL4548303 IC50 0.67 nM
C[C@@H]1CN(c2ccnc3cc(-c4ccncc4)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4530395 IC50 0.7 nM
C[C@@H]1CN(c2c(Cl)cnc3cc(-c4ncco4)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4448749 IC50 0.7 nM
CCNC(=O)c1ccc2c(N3CC[C@H](C(=O)N4CCn5c(nnc5C(F)(F)F)C4)[C@H](C)C3)c(Cl)cnc2c1 CHEMBL4554911 IC50 0.7 nM
C[C@@H]1CN(c2c(C(F)F)cnc3c(F)c(Cl)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4554958 IC50 0.7 nM
C[C@@H]1CN(c2c(Cl)cnc3c2CCN(CC(F)(F)F)C3)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4572213 IC50 0.8 nM
C[C@@H]1CN(c2c(Cl)c[n+]([O-])c3cc(C(F)(F)F)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4439430 IC50 0.8 nM
C[C@@H]1CN(c2c(Cl)cnc3c(F)cccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4461268 IC50 0.9 nM
C[C@@H]1CN(c2c(Cl)cnc3c2CCN(CC2CC2)C3)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4474123 IC50 1.0 nM
C[C@@H]1CN(c2c(C(F)(F)F)cnc3ccccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4438423 IC50 1.0 nM
C[C@@H]1CN(c2ccnc3cc(C(C)(F)F)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4515105 IC50 1.1 nM
C[C@@H]1CN(c2c(Cl)cnc3cc(S(C)(=O)=O)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4468368 IC50 1.2 nM
COc1cnc2c(N3CC[C@H](C(=O)N4CCn5c(nnc5C(F)(F)F)C4)[C@H](C)C3)c(Cl)cnc2c1 CHEMBL4519936 IC50 1.2 nM
C[C@@H]1CN(c2c(Cl)cnc3nc(C(F)(F)F)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4555269 IC50 1.3 nM
Cc1coc(-c2ccc3c(N4CC[C@H](C(=O)N5CCn6c(nnc6C(F)(F)F)C5)[C@H](C)C4)ccnc3c2)n1 CHEMBL4592478 IC50 1.4 nM
C[C@@H]1CN(c2c(F)cnc3cc(Cl)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4520631 IC50 1.7 nM
C[C@@H]1CN(c2c(Cl)cnc3c2CCN(C(=O)C2CC2)C3)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4460219 IC50 1.75 nM
C[C@@H]1CN(c2ccnc3ccc(Cl)cc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4434819 IC50 3.5 nM
C[C@@H]1CN(c2ccnc3cc(OCC4CC4)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4474799 IC50 3.6 nM
C[C@@H]1CN(c2ccnc3cc(OCc4ccccc4)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4459888 IC50 3.91 nM
CC(C)NC(=O)c1ccc2c(N3CC[C@H](C(=O)N4CCn5c(nnc5C(F)(F)F)C4)[C@H](C)C3)ccnc2c1 CHEMBL4535204 IC50 4.5 nM
C[C@@H]1CN(c2ccnc3cc(C(F)(F)F)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4514892 IC50 5.2 nM
C[C@@H]1CN(c2c(C(N)=O)cnc3cc(OCC4CC4)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4438582 IC50 5.29 nM
C[C@@H]1CN(c2ccnc3cc(C(F)F)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4469039 IC50 5.97 nM
C[C@@H]1CN(c2ccnc3cc(Cl)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4588950 IC50 6.3 nM
C[C@@H]1CN(c2ccnc3c2CCN(C(=O)OC(C)(C)C)C3)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4555917 IC50 8.2 nM
C[C@@H]1CN(c2ccnc3cc(OC(F)F)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4577908 IC50 8.3 nM
C[C@@H]1CN(c2ccnc3cc(C#N)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4548206 IC50 8.4 nM
CC1CN(c2ccnc3ccc(Cl)cc23)CCC1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4576338 IC50 8.5 nM
C[C@@H]1CN(c2ccnc3c(F)c(Cl)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4554615 IC50 14.0 nM
C[C@@H]1CN(c2ccnc3cc(Cl)cnc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4444714 IC50 18.0 nM
COc1ccc2nccc(N3CC[C@H](C(=O)N4CCn5c(nnc5C(F)(F)F)C4)[C@H](C)C3)c2n1 CHEMBL4458789 IC50 18.0 nM
C[C@@H]1CN(c2ccnc3cc(F)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4438677 IC50 19.0 nM
C[C@@H]1CN(c2ccnc3cc(C(=O)NC45CC(C4)C5)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4593871 IC50 21.1 nM
C[C@@H]1CN(c2ccnc3cc(C(=O)NCC4CC4)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4519145 IC50 23.6 nM
Cc1nc2ccc(F)cc2c(N2CC[C@H](C(=O)N3CCn4c(nnc4C(F)(F)F)C3)[C@H](C)C2)c1C CHEMBL4558732 IC50 37.0 nM
C[C@@H]1CN(c2ccnc3cc(-n4cncn4)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4526155 IC50 41.7 nM
C[C@@H]1CN(c2ccnc3c2CCN(C(=O)OC2(C)CC2)C3)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4441148 IC50 49.0 nM
C[C@@H]1CN(c2ccnc3ccc(F)cc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4553721 IC50 52.0 nM
Cc1cc(N2CC[C@H](C(=O)N3CCn4c(nnc4C(F)(F)F)C3)[C@H](C)C2)c2ccc(Cl)cc2n1 CHEMBL4476381 IC50 107.0 nM
C[C@@H]1CN(c2ccnc3c(Cl)c(Cl)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4440002 IC50 111.0 nM
C[C@@H]1CN(c2ccnc3c2CCN(CC(F)(F)F)C3)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4472435 IC50 120.0 nM
Cc1cc(N2CC[C@H](C(=O)N3CCn4c(nnc4C(F)(F)F)C3)[C@H](C)C2)c2cc(F)cc(F)c2n1 CHEMBL4591309 IC50 145.0 nM
COc1ccc2c(N3CC[C@H](C(=O)N4CCn5c(nnc5C(F)(F)F)C4)[C@H](C)C3)ccnc2c1 CHEMBL4459757 IC50 237.0 nM
Cc1cc(N2CC[C@H](C(=O)N3CCn4c(nnc4C(F)(F)F)C3)[C@H](C)C2)c2cc(F)ccc2n1 CHEMBL4590760 IC50 245.0 nM
C[C@@H]1CN(c2ccnc3cc(S(C)(=O)=O)ccc23)CC[C@@H]1C(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL4442785 IC50 305.0 nM
COc1cnc2c(N3CC[C@H](C(=O)N4CCn5c(nnc5C(F)(F)F)C4)[C@H](C)C3)ccnc2c1 CHEMBL4588436 IC50 307.0 nM
Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 CHEMBL808 IC50 310.0 nM
CCNC(=O)c1ccc2c(N3CC[C@H](C(=O)N4CCn5c(nnc5C(F)(F)F)C4)[C@H](C)C3)ccnc2c1 CHEMBL4456347 IC50 368.0 nM
Cc1cc(N2CC[C@H](C(=O)N3CCn4c(nnc4C(F)(F)F)C3)[C@H](C)C2)c2ccc(F)c(F)c2n1 CHEMBL4470033 IC50 385.0 nM
Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 CHEMBL104 IC50 800.0 nM