CCCc1sc(-c2ccc(OC)c(OCCNS(C)(=O)=O)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426574 Ki(app) 0.5 nM
CCCc1sc(-c2ccc(OC)c(OCCO)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426570 Ki(app) 0.5 nM
N#Cc1ccccc1Oc1ncnc(N2CCC(Oc3nccc(N)n3)CC2)c1F CHEMBL1081002 IC50 0.7 nM
CCCc1sc(-c2ccc(OC)c(OCC(C)(C)O)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426573 Ki(app) 0.8 nM
CCCc1sc(-c2ccc(OCCO)c(OCCO)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426567 IC50 0.9 nM
N#Cc1ccccc1Oc1ncnc(N2CCC(Oc3ncc(F)c(N)n3)CC2)c1F CHEMBL1080093 IC50 1.0 nM
COc1ccc(C#N)cc1Oc1ncnc(N2CCC(Oc3ncc(F)c(N)n3)CC2)c1F CHEMBL1081903 IC50 1.0 nM
CCCc1sc(-c2ccc(F)c(OCCO)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426563 IC50 1.07 nM
CCOc1cc(-c2nc([C@@H](C)Sc3nc(N)cc(N)n3)c(C)s2)ccc1OCCOCCOCCOC CHEMBL3358096 IC50 1.25 nM
CCCc1sc(-c2ccc(OC)c(OCCF)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426558 Ki(app) 1.5 nM
CCCc1sc(-c2ccc(OC)c(OCCCO)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426569 IC50 1.55 nM
Nc1nc(=O)n([C@H]2CC[C@H](NC(=O)c3cc(-c4cc5ccccc5s4)ccn3)C2)cc1F CHEMBL1080444 IC50 1.7 nM
CCCc1sc(-c2ccc(OC)c(OCC(C)(C)O)c2)nc1CSc1nccc(N)n1 CHEMBL3358091 Ki(app) 1.8 nM
CCCc1sc(-c2cccc(OCCNS(C)(=O)=O)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426565 Ki(app) 1.9 nM
COc1ccc(Oc2ncnc(N3CCC(Oc4ncc(F)c(N)n4)CC3)c2F)c(C#N)c1 CHEMBL1081904 IC50 2.0 nM
CCCc1sc(-c2cccc(OCCO)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426562 IC50 2.45 nM
CCCc1sc(-c2cc(F)cc(OCCO)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426564 IC50 2.83 nM
CCCc1sc(-c2ccc(OC)c(OCC(C)O)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426572 IC50 2.85 nM
CCCc1sc(-c2ccc(OC)c(OCCO)c2)nc1CSc1nccc(N)n1 CHEMBL2426571 IC50 2.9 nM
Nc1nc(OCCC2CCN(c3cc(-c4cc5ccccc5s4)ncn3)CC2)ncc1F CHEMBL1079768 IC50 3.0 nM
Nc1nc(OC2CCN(c3cc(Oc4ccccc4-c4ccccc4)ncn3)CC2)ncc1F CHEMBL1081350 IC50 3.0 nM
Nc1nc(OC2CCN(c3cc(Oc4ccccc4Cl)ncn3)CC2)ncc1F CHEMBL1080443 IC50 3.0 nM
N#Cc1ccccc1Oc1cc(N2CCC(Oc3ncc(F)c(N)n3)CC2)ncn1 CHEMBL1079906 IC50 3.0 nM
COc1ccc(Oc2cc(N3CCC(Oc4ncc(F)c(N)n4)CC3)ncn2)c(C#N)c1 CHEMBL1080636 IC50 3.0 nM
COc1ccc(-c2nc([C@@H](C)Sc3nc(N)cc(N)n3)c(C)s2)cc1OCCNS(C)(=O)=O CHEMBL3358097 IC50 3.7 nM
COc1ccc(Oc2ncnc(N3CCC(Oc4ncc(F)c(N)n4)CC3)c2F)cc1 CHEMBL1079379 IC50 4.0 nM
N#Cc1cccc(Oc2ncnc(N3CCC(Oc4ncc(F)c(N)n4)CC3)c2F)c1 CHEMBL1079380 IC50 4.0 nM
COc1ccccc1Oc1cc(N2CCC(Oc3ncc(F)c(N)n3)CC2)ncn1 CHEMBL1079601 IC50 5.0 nM
N#Cc1ccccc1Oc1ncnc(N2CCC(Oc3ncc(F)c(N)n3)CC2)c1Br CHEMBL1080092 IC50 5.0 nM
N#Cc1ccc(Oc2ncnc(N3CCC(Oc4ncc(F)c(N)n4)CC3)c2F)cc1 CHEMBL1081727 IC50 5.0 nM
Nc1nc(OC2CCN(c3cc(Oc4ccccc4F)ncn3)CC2)ncc1F CHEMBL1081901 IC50 6.0 nM
COc1ccc(-c2nc(C(C)Sc3nc(N)cc(N)n3)c(C)s2)cc1OCCF CHEMBL3358094 Ki(app) 6.8 nM
CCc1sc(-c2ccc(OC)c(OCCF)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426598 IC50 7.0 nM
CCCc1sc(-c2cc(F)cc(OCCNS(C)(=O)=O)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426566 IC50 8.01 nM
CCCc1sc(-c2ccc(OC)c(O)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426568 Ki(app) 8.9 nM
Cc1ccccc1Oc1cc(N2CCC(Oc3ncc(F)c(N)n3)CC2)ncn1 CHEMBL1079603 IC50 9.0 nM
Cc1cc(Cl)ccc1Oc1cc(N2CCC(Oc3ncc(F)c(N)n3)CC2)ncn1 CHEMBL1081544 IC50 9.0 nM
COc1ccc(-c2nc(CSc3nc(N)cc(N)n3)c(C)s2)cc1OCCF CHEMBL2426588 Ki(app) 9.5 nM
CCc1ccccc1Oc1cc(N2CCC(Oc3ncc(F)c(N)n3)CC2)ncn1 CHEMBL1079735 IC50 10.0 nM
Cc1nc(Oc2ccccc2C#N)cc(N2CCC(Oc3ncc(F)c(N)n3)CC2)n1 CHEMBL1080818 IC50 10.0 nM
CCCc1sc(-c2ccc(OC)c(OCCF)c2)nc1C(C)Sc1nc(N)cc(N)n1 CHEMBL3358093 IC50 10.0 nM
CCc1sc(-c2cccc(F)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426557 IC50 11.0 nM
Nc1nc(N)c2nc(-c3cccc(O)c3)c(-c3cccc(O)c3)nc2n1 CHEMBL230011 Kd apparent 12.0 nM
N#Cc1cccc(Oc2cc(N3CCC(Oc4ncc(F)c(N)n4)CC3)ncn2)c1 CHEMBL1079907 IC50 13.0 nM
Nc1nc(OC2CCN(c3cc(Oc4ccc(Cl)cc4)ncn3)CC2)ncc1F CHEMBL1081351 IC50 19.0 nM
Cc1ccc(Oc2cc(N3CCC(Oc4ncc(F)c(N)n4)CC3)ncn2)cc1 CHEMBL1079602 IC50 21.0 nM
Cc1c(Oc2ccccc2C#N)ncnc1N1CCC(Oc2ncc(F)c(N)n2)CC1 CHEMBL1080817 IC50 21.0 nM
Nc1nc(=O)n([C@H]2CC[C@H](NS(=O)(=O)c3cccc(-c4ccc(Cl)cc4Cl)c3)C2)cc1F CHEMBL1079771 IC50 21.0 nM
Cc1cc(Cl)ccc1-c1cccc(S(=O)(=O)N[C@H]2CC[C@H](n3cc(F)c(N)nc3=O)C2)c1 CHEMBL1079432 IC50 21.0 nM
Cc1cc(Cl)ccc1-c1cccc(C(=O)N[C@H]2CC[C@H](n3cc(F)c(N)nc3=O)C2)c1 CHEMBL1079784 IC50 21.0 nM
Nc1nc(OC2CCN(c3cc(Oc4cccc(Cl)c4)ncn3)CC2)ncc1F CHEMBL1081352 IC50 22.0 nM
COc1cccc(Oc2cc(N3CCC(Oc4ncc(F)c(N)n4)CC3)ncn2)c1 CHEMBL1076272 IC50 23.0 nM
Nc1nc(=O)n([C@H]2CC[C@H](NC(=O)c3cccc(-c4cccc(Cl)c4)c3)C2)cc1F CHEMBL1076274 IC50 23.0 nM
COc1ccc(-c2cccc(C(=O)N[C@H]3CC[C@H](n4cc(F)c(N)nc4=O)C3)c2)cc1 CHEMBL1079600 IC50 30.0 nM
CCCc1sc(-c2cccc(F)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426561 IC50 31.0 nM
COc1ccc(Oc2cc(N3CCC(Oc4ncc(F)c(N)n4)CC3)ncn2)cc1 CHEMBL1079770 IC50 33.0 nM
Nc1nc(OCC2CCN(c3cc(-c4cc5ccccc5s4)ncn3)CC2)ncc1F CHEMBL1079585 IC50 34.0 nM
CCCc1sc(-c2ccc(F)cc2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426560 IC50 37.0 nM
Nc1nc(OC2CCN(c3cc(-c4cc5ccccc5s4)ncn3)CC2)ncc1F CHEMBL1081561 IC50 38.0 nM
Nc1nc(=O)n([C@H]2CC[C@H](NC(=O)c3cccc(-c4ccc(Cl)cc4)c3)C2)cc1F CHEMBL1079783 IC50 42.0 nM
Nc1nc(=O)n([C@H]2CC[C@H](NS(=O)(=O)c3cccc(-c4ccccc4Cl)c3)C2)cc1F CHEMBL1079415 IC50 45.0 nM
N#Cc1ccc(-c2cccc(S(=O)(=O)N[C@H]3CC[C@H](n4cc(F)c(N)nc4=O)C3)c2)cc1 CHEMBL1079397 IC50 49.0 nM
Nc1nc(=O)n([C@H]2CC[C@H](NS(=O)(=O)c3cccc(-c4ccc(Cl)cc4)c3)C2)cc1F CHEMBL1079759 IC50 51.0 nM
N#Cc1ccccc1Oc1ncnc(N2CCC(On3ccc(N)nc3=O)CC2)c1F CHEMBL1080829 IC50 63.0 nM
CS(=O)(=O)c1ccc(-c2cccc(S(=O)(=O)N[C@H]3CC[C@H](n4cc(F)c(N)nc4=O)C3)c2)cc1 CHEMBL1079398 IC50 63.0 nM
COc1ccc(-c2cccc(S(=O)(=O)N[C@H]3CC[C@H](n4cc(F)c(N)nc4=O)C3)c2)cc1 CHEMBL1082101 IC50 64.0 nM
Nc1nc(=O)n([C@H]2CC[C@H](NS(=O)(=O)c3cccc(-c4cccc(Cl)c4)c3)C2)cc1F CHEMBL1079760 IC50 79.0 nM
CCc1sc(-c2ccc(F)cc2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426460 IC50 83.0 nM
NC(=O)c1ccc(-c2cccc(S(=O)(=O)N[C@H]3CC[C@H](n4cc(F)c(N)nc4=O)C3)c2)cc1 CHEMBL1079399 IC50 89.0 nM
Cc1sc(-c2cccc(F)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426591 IC50 92.0 nM
COc1ccc(-c2nc([C@H](C)Sc3nc(N)cc(N)n3)c(C)s2)cc1OCCNS(C)(=O)=O CHEMBL3358090 IC50 94.0 nM
Nc1nc(OC2CCN(c3cc(Oc4ccccc4)ncn3)CC2)ncc1F CHEMBL1079769 IC50 95.0 nM
Cc1ccc(-c2cccc(S(=O)(=O)N[C@H]3CC[C@H](n4cc(F)c(N)nc4=O)C3)c2)cc1 CHEMBL1081189 IC50 110.0 nM
Nc1nc(=O)n([C@H]2CC[C@H](NS(=O)(=O)c3cccc(-c4ccccc4)c3)C2)cc1F CHEMBL1081006 IC50 120.0 nM
Cc1sc(-c2cc(F)cc(F)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426589 IC50 150.0 nM
CCc1sc(-c2cc(F)cc(F)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426459 IC50 162.0 nM
CCCc1sc(-c2cc(F)cc(F)c2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426559 IC50 173.0 nM
COc1ccc(-c2nc(CSc3nc(N)cc(N)n3)cs2)cc1OCCCF CHEMBL2426585 IC50 197.0 nM
Cc1sc(-c2ccc(F)cc2)nc1CSc1nc(N)cc(N)n1 CHEMBL2426590 IC50 230.0 nM
COc1ccc(-c2nc(CSc3nc(N)cc(N)n3)cs2)cc1OCCF CHEMBL2426582 IC50 230.0 nM
CCOc1ccc(-c2nc(CSc3nc(N)cc(N)n3)cs2)cc1OCCF CHEMBL2426583 IC50 251.0 nM
Nc1nc(=O)n([C@H]2CC[C@H](NC(=O)c3cccc(-c4ccccc4)c3)C2)cc1F CHEMBL1079433 IC50 260.0 nM
COc1ccc(-c2nc(CSc3nc(N)nc(N)n3)cs2)cc1OCCCF CHEMBL2426596 IC50 297.0 nM
Nc1nc(=O)n([C@H]2CC[C@H](NS(=O)(=O)c3ccc(-c4ccccc4)cc3)C2)cc1F CHEMBL1081909 IC50 350.0 nM
CCCc1sc(-c2ccc(OC)c(OCC(C)(C)O)c2)nc1CSc1cc(N)nc(N)n1 CHEMBL3358092 IC50 395.0 nM
Nc1ccn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1 CHEMBL66115 Km 400.0 nM
COc1cc(-c2nc(CSc3nc(N)cc(N)n3)cs2)ccc1OCCF CHEMBL2426581 IC50 421.0 nM
CCOc1cc(-c2nc([C@H](C)Sc3nc(N)cc(N)n3)c(C)s2)ccc1OCCOCCOCCOC CHEMBL3358095 IC50 429.5 nM
COc1ccc(-c2nc(CSc3nc(N)nc(N)n3)cs2)cc1OCCF CHEMBL2426593 IC50 506.0 nM
O=C(CN1CCN(c2cc(-c3cc4ccccc4s3)ncn2)CC1)N1CCCC1 CHEMBL1081559 IC50 510.0 nM
CCOc1ccc(-c2nc(CSc3nc(N)nc(N)n3)cs2)cc1OCCF CHEMBL2426594 IC50 512.0 nM
COc1cc(-c2nc(CSc3nc(N)nc(N)n3)cs2)ccc1OCCF CHEMBL2426592 IC50 534.0 nM
Nc1nc(Oc2cc(-c3cc4ccccc4s3)ncn2)ncc1F CHEMBL1081560 IC50 720.0 nM
COc1ccc(OCCF)cc1-c1nc(CSc2nc(N)nc(N)n2)cs1 CHEMBL2426597 IC50 849.0 nM