COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 0.2 nM
Cc1cc(C)c(-n2ccn3nc(-c4cccnc4)cc23)cc1NC(=O)c1cc(C#N)cc(S(F)(F)(F)(F)F)c1 CHEMBL3907057 Kd 0.4 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 IC50 0.5 nM
CCc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2ccnn2c1 CHEMBL2336015 Kd 0.6 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 0.69 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL941 Kd 0.7 nM
Cn1ccc(-c2cncc(CNc3cc(C(=O)Nc4cccc(OC(F)(F)F)c4)ccc3F)c2)n1 CHEMBL4539920 IC50 0.7078 nM
Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1 CHEMBL255863 Kd 1.1 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 Kd 1.5 nM
COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 CHEMBL491473 Kd 1.7 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(OCCO)nc(N2CCOCC2)c1 CHEMBL4583691 Kd 1.8 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 CHEMBL103667 Kd 1.9 nM
Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12 CHEMBL3969260 IC50 2.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 2.09 nM
Cc1cc(NC(=O)c2cccc(S(F)(F)(F)(F)F)c2)cc(-n2ccn3nc(-c4cccnc4)cc23)c1 CHEMBL4526351 Kd 2.1 nM
C[C@H]1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(CN4CCCN(C)CC4)cc(C(F)(F)F)c3)ccc21 CHEMBL4097012 Kd 2.2 nM
Cc1ccc(C(=O)Nc2cccc(Cl)c2)cc1C#Cc1cnc2ccnn2c1 CHEMBL2336037 IC50 2.29 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 2.4 nM
Cc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2cnccn12 CHEMBL4161036 IC50 2.4 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL400402 Kd apparent 3.0 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]cnc23)CC1 CHEMBL4466555 IC50 3.0 nM
CCc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2cnccn12 CHEMBL4175086 IC50 3.2 nM
Cc1nc(Nc2nc3ccc(-c4cccc(C(=O)Nc5cccc(C(F)(F)F)c5)c4)nc3s2)cc(N2CCNCC2)n1 CHEMBL2148120 Kd 3.4 nM
CCc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL4164448 IC50 3.9 nM
CCc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc(N)nc1 CHEMBL4164030 IC50 3.9 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1NCc1cncc(C(N)=O)c1 CHEMBL4439970 IC50 3.97 nM
COc1cccc(NC(=O)c2ccc(C)c(C#Cc3cnc4ccnn4c3)c2)c1 CHEMBL2336040 IC50 4.04 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5cccc(NS(C)(=O)=O)c5)c4n3)cc2)CC1 CHEMBL4846921 IC50 4.4 nM
Nc1nc2cc(-c3nn(CC4CCCC4)c4ncnc(N)c34)ccc2o1 CHEMBL3797933 IC50 4.7 nM
Cc1cn(-c2cc(NC(=O)c3ccc4c(c3)CN(c3cncnc3)C[C@@H]4C)cc(C(F)(F)F)c2)cn1 CHEMBL4553037 Kd 4.7 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1cncc(C(N)=O)c1 CHEMBL552425 IC50 4.799 nM
CC(=O)c1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1 CHEMBL3944137 IC50 5.0 nM
CN1CCN(C2CCN(C(=O)Nc3cc(Oc4ccc(NC(=O)C5(C(=O)Nc6ccc(F)cc6)CC5)c(F)c4)ccn3)CC2)CC1 CHEMBL3039525 Kd apparent 5.0 nM
CCc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc(NC)nc1 CHEMBL4174682 IC50 5.0 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2ccnn2c1 CHEMBL4794765 IC50 5.0 nM
Cc1cn(-c2cc(NC(=O)c3ccc4c(c3)C[C@H](Nc3cncnc3)C4)cc(C(F)(F)F)c2)cn1 CHEMBL4558430 IC50 5.6 nM
COc1cncc(CNc2cc(C(=O)Nc3cccc(C(F)(F)F)c3)ccc2C)c1 CHEMBL4467377 IC50 5.89 nM
Cc1cn(-c2cc(NC(=O)c3ccc4c(c3)C[C@H](N(C)c3cncnc3)C4)cc(C(F)(F)F)c2)cn1 CHEMBL4437631 Kd 5.9 nM
Cc1cccc(NC(=O)c2ccc(C)c(C#Cc3cnc4ccnn4c3)c2)c1 CHEMBL2331602 IC50 5.96 nM
Cc1ccc([C@H](C)NC(=O)Nc2ccccc2)cc1NC(=O)c1cnc2ccccn12 CHEMBL3608787 IC50 6.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1C#Cc1cnc2ccnn2c1 CHEMBL2336021 IC50 6.14 nM
CCc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2ccccn12 CHEMBL4171640 IC50 6.2 nM
Cc1cc(C)cc(NC(=O)c2ccc(C)c(C#Cc3cnc4ccnn4c3)c2)c1 CHEMBL2336006 IC50 6.34 nM
Cc1cc(CN2CCN(C)CC2)cc(NC(=O)c2ccc(C)c(C#Cc3cnc4ccnn4c3)c2)c1 CHEMBL2336009 IC50 6.71 nM
CN1CCN(Cc2cc(NC(=O)c3cccc(C#Cc4cnc5ccnn5c4)c3)cc(C(F)(F)F)c2)CC1 CHEMBL2336017 IC50 7.02 nM
Cc1cccc(C(=O)Nc2cccc([C@H](C)Nc3cncc(Cl)n3)c2)c1 CHEMBL504075 Kd 7.8 nM
CCc1ccc(C(=O)Nc2cc(F)cc(C(F)(F)F)c2)cc1-c1cc(C)cc(-c2cnc3cnccn23)c1 CHEMBL4519003 Kd 7.8 nM
CCc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc(C)n1C CHEMBL4167877 IC50 7.9 nM
CC(C)c1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2cnccn12 CHEMBL4168305 Kd 7.9 nM
CCn1cc(-c2ccnc3[nH]c(-c4cccc(CN(C)C)c4)cc23)c(-c2ccc(NC(=O)N(C)C)cc2)n1 CHEMBL1090479 Kd apparent 8.0 nM
CCc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cncnc1 CHEMBL4159558 IC50 8.4 nM
COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cnn(C)c1 CHEMBL5176837 IC50 8.5 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1NCc1cncc(-c2ccn(C)n2)c1 CHEMBL4546339 IC50 8.53 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nc(-c2cccnc2)cs1 CHEMBL1908391 Kd 8.7 nM
CCc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1-c1cccc(-c2cnc3cnccn23)c1 CHEMBL4473475 IC50 8.7 nM
Cc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2ccnn2c1 CHEMBL2336008 IC50 8.93 nM
CCN1CCN(Cc2ccc(C(=O)Nc3ccc(C)c(NCc4cnc5[nH]ccc5c4OC)c3)cc2C(F)(F)F)CC1 CHEMBL3422019 IC50 9.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cc(-c4ccc(OCCN5CCOCC5)cc4)[nH]n3)cc2)no1 CHEMBL5407834 IC50 9.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cccc(-c2cnc3cnccn23)c1 CHEMBL4464080 IC50 9.2 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 9.3 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 9.4 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 IC50 9.4 nM
Cc1ccc(C(=O)Nc2cccc(N(C)C)c2)cc1C#Cc1cnc2ccnn2c1 CHEMBL2336024 IC50 9.72 nM
Cc1ccc2c(Nc3cccc(C(F)(F)F)c3)noc2c1C#Cc1cnc2cccnn12 CHEMBL4632409 IC50 10.0 nM
CN1CCN(Cc2cc(NC(=O)c3ccc(Cl)c(C#Cc4cnc5ccnn5c4)c3)cc(C(F)(F)F)c2)CC1 CHEMBL2336016 IC50 10.05 nM
CCOc1cc(N2CCN(C)CC2)ccc1Nc1ncc2cc(-c3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)c(=O)n(C[C@H]3CCCO3)c2n1 CHEMBL5415503 IC50 10.12 nM
CCN1CCN(Cc2ccc(C(=O)Nc3ccc(C)c(Oc4ccc5c(c4)NC(=O)C5)c3)cc2C(F)(F)F)CC1 CHEMBL5072982 IC50 10.2 nM
CCc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cccc(-c2cnc3cnccn23)c1 CHEMBL4438475 IC50 10.4 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1NCc1cccnc1 CHEMBL4447700 IC50 10.5 nM
CC(=O)Nc1ccc(-n2nc3c(=O)[nH]nc(N)c3c2-c2oc3cc(C(=O)Nc4cccc(C(F)(F)F)c4)ccc3c2C)cc1 CHEMBL5076889 IC50 10.6 nM
COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 CHEMBL24828 Kd 11.0 nM
CC(C)c1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL4172767 IC50 11.4 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 12.0 nM
COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 CHEMBL1908396 Kd 12.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2ccnn2c1 CHEMBL2336014 IC50 12.47 nM
CC(C)c1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2ccccn12 CHEMBL4167237 IC50 12.5 nM
CN1CCN(Cc2cc(NC(=O)c3ccc(C4CC4)c(C#Cc4cnc5cnccn45)c3)cc(C(F)(F)F)c2)CC1 CHEMBL4176145 IC50 12.6 nM
Cn1c(Nc2ccc(C(F)(F)F)cc2)nc2cc(Oc3ccnc(-c4ncc(C(F)(F)F)[nH]4)c3)ccc21 CHEMBL558752 Kd 13.0 nM
CCc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1ccc2ccnn2c1 CHEMBL4077561 IC50 13.1 nM
COc1cc(CN2CCN(C)CC2)cc(NC(=O)c2ccc(C)c(C#Cc3cnc4ccnn4c3)c2)c1 CHEMBL2336011 IC50 13.3 nM
Cc1ccc(C(=O)Nc2cc(Cl)cc(CN3CCN(C)CC3)c2)cc1C#Cc1cnc2ccnn2c1 CHEMBL2336010 IC50 13.94 nM
Cc1ccc(NC(=O)c2ccc(CN3CC[C@H](N(C)C)C3)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cncnc2)n1 CHEMBL206834 Kd apparent 14.0 nM
CNC(=O)c1cccc2cc(Oc3ccnc4cc(OCC5(N)CC5)c(OC)cc34)ccc12 CHEMBL2220486 Kd apparent 14.0 nM
Cc1cn(-c2cc(NC(=O)c3ccc4c(c3)C[C@H](N(C)c3cncnc3)C4)cc(C(C)(C)C)c2)cn1 CHEMBL4472004 IC50 14.4 nM
CCc1cc(NC(=O)c2ccc3c(c2)C[C@H](N(C)c2cncnc2)C3)cc(-n2cnc(C)c2)c1 CHEMBL4541139 IC50 14.7 nM
Cc1ccc(-c2cn([C@H]3CC[C@@H](N)CC3)c3ncnc(N)c23)c(F)c1 CHEMBL5177284 IC50 15.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1NCc1cncc(-c2ccc[nH]2)c1 CHEMBL4584937 IC50 15.2 nM
Cc1cn(-c2cc(NC(=O)c3ccc4c(c3)C[C@H](N(C)c3cncnc3)C4)cc(C(C)C)c2)cn1 CHEMBL4441609 IC50 15.5 nM
CCc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(C#N)cc(-c2cnc3cnccn23)c1 CHEMBL4583783 IC50 15.6 nM
CCc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cncn1C CHEMBL4159956 IC50 16.0 nM
O=C(CN1CN(c2ccccc2)C2(CCN(C(=O)c3cnc4[nH]ncc4c3)CC2)C1=O)NCC(F)(F)F CHEMBL4649685 IC50 16.0 nM
CCc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(OC)cc(-c2cnc3cnccn23)c1 CHEMBL4466438 IC50 16.5 nM
Cc1ccc(C(=O)Nc2cccc(Br)c2)cc1C#Cc1cnc2ccnn2c1 CHEMBL2336019 IC50 16.64 nM
Cc1ccc(C(=O)Nc2cc(CN3CCOCC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2ccnn2c1 CHEMBL2336012 IC50 17.49 nM
Cc1ccc(C(=O)Nc2cccc(-n3ccnc3)c2)cc1C#Cc1cnc2ccnn2c1 CHEMBL2336025 IC50 19.03 nM
Cc1ccc(C(=O)Nc2cccc(I)c2)cc1C#Cc1cnc2ccnn2c1 CHEMBL2336020 IC50 19.75 nM
CC1CN(c2cncnc2)Cc2cc(C(=O)Nc3ccc(CN4CCN(C)CC4)c(C(F)(F)F)c3)ccc21 CHEMBL4088784 IC50 19.9 nM
Nc1nc(Nc2ccc3c(c2)CC[C@@H](N2CCCC2)CC3)nn1-c1cc2c(nn1)-c1ccccc1CCC2 CHEMBL3809489 IC50 20.0 nM
CC1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(CN4CCN(C)CC4)cc(C(F)(F)F)c3)ccc21 CHEMBL4087485 IC50 21.0 nM
CCc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(Cl)cc(-c2cnc3cnccn23)c1 CHEMBL4444612 IC50 21.3 nM
CCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4cc(OC)c(OC)cc34)c(F)c1)c(C)n2C CHEMBL4571241 IC50 22.2 nM
COc1ccc(NC(=O)c2ccc(C)c(C#Cc3cnc4ccnn4c3)c2)cc1 CHEMBL2336018 IC50 22.36 nM
CCc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(C)cc(-c2cnc3cnccn23)c1 CHEMBL4555024 IC50 22.5 nM
Cc1ccc2c(Nc3cccc(Cl)c3F)nccc2c1NC(=O)c1csc2c(N)ncnc12 CHEMBL3977543 IC50 23.0 nM
CS(=O)(=O)N1CCCC(NC(=O)[C@H](CCC2CCCCC2)NC(=O)c2ccc(CNC(=O)c3cnc4ccccn34)cc2)C1 CHEMBL4591082 IC50 23.0 nM
Cc1c2cc(cc1C(=O)Nc1cc(CN3CCN(C)CC3)cc(C3CC3)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5423601 IC50 23.76 nM
C[C@H]1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(CN4CCN(C)CC4)cc(C(F)(F)F)c3)ccc21 CHEMBL4066114 IC50 24.3 nM
CC1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(CN4CCCN(C)CC4)cc(C(F)(F)F)c3)ccc21 CHEMBL4075510 IC50 25.6 nM
Cc1cn(-c2cc(NC(=O)c3cc4cc(c3C)C#Cc3cnc5ccc(nn35)N(C)CCNC(=O)CCCCO4)cc(C(F)(F)F)c2)cn1 CHEMBL5195469 IC50 26.4 nM
Cc1c(-c2c3c(N)n[nH]c(=O)c3nn2-c2ccccc2)oc2cc(C(=O)Nc3cccc(C(F)(F)F)c3)ccc12 CHEMBL5082740 IC50 27.5 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 Kd 28.0 nM
O=C(CN1C(=O)C2(CCN(C(=O)c3ccc4[nH]ncc4n3)CC2)c2c(Br)cccc21)NCC(F)(F)F CHEMBL4635278 IC50 29.0 nM
Cc1ccc(C(=O)NC2CCCCC2)cc1C#Cc1cnc2ccnn2c1 CHEMBL2336031 IC50 29.15 nM
Cc1cc(Cl)cc(NC(=O)c2ccc(C)c(C#Cc3cnc4ccnn4c3)c2)c1 CHEMBL2336007 IC50 29.81 nM
CCc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cccc(-c2cnc3cnccn23)c1C CHEMBL4586565 IC50 30.1 nM
CCc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(F)cc(-c2cnc3cnccn23)c1 CHEMBL4571430 IC50 30.3 nM
CCNC(=O)[C@H](CCC1CCCCC1)NC(=O)c1ccc(CNC(=O)c2cnn(-c3ccccc3)c2N)cc1 CHEMBL4756586 Kd 31.0 nM
CNc1ncc2c(-c3ccc(N4CCN(C)CC4)cc3)nn(CC3CCCC3)c2n1 CHEMBL4218175 IC50 35.0 nM
CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4281823 IC50 35.0 nM
Cc1ccc(C(=O)Nc2cccc(OC(C)C)c2)cc1C#Cc1cnc2ccnn2c1 CHEMBL2336023 IC50 35.02 nM
Cc1ccc(C(=O)Nc2ccc(C)c(C(F)(F)F)c2)cc1NCc1cncc(-c2ccc[nH]2)c1 CHEMBL4483465 IC50 36.4 nM
CC[C@H]1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(CN4CCN(C)CC4)cc(C(F)(F)F)c3)ccc21 CHEMBL4435100 IC50 36.4 nM
CCc1ccc(C(=O)Nc2cc(C(F)(F)F)ccc2F)cc1-c1cc(C)cc(-c2cnc3cnccn23)c1 CHEMBL4440007 IC50 36.5 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCCC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2ccnn2c1 CHEMBL2336013 IC50 37.58 nM
Cc1ccc(C(=O)Nc2ccccc2)cc1C#Cc1cnc2ccnn2c1 CHEMBL2336033 IC50 38.9 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4ccccc34)cc2)n(-c2cccc(N)c2)n1 CHEMBL2403816 IC50 39.0 nM
CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 CHEMBL460702 Kd apparent 39.0 nM
Cc1ccc(C(=O)NC(C)C)cc1C#Cc1cnc2ccnn2c1 CHEMBL2336028 IC50 39.63 nM
Cc1ccc(C(=O)NC2CCCC2)cc1C#Cc1cnc2ccnn2c1 CHEMBL2336032 IC50 39.82 nM
Cc1ccc2c(Nc3cccc(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12 CHEMBL3954810 IC50 40.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)cc(OC)c1OC CHEMBL4517408 IC50 41.0 nM
CCc1cc(-c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)ccc2CC)cc(-c2cnc3cnccn23)c1 CHEMBL4447486 IC50 42.3 nM
Cc1cn(-c2cc(NC(=O)c3ccc4c(c3)C[C@@H](Nc3cncnc3)C4)cc(C(F)(F)F)c2)cn1 CHEMBL4472914 IC50 42.5 nM
CC(=O)Nc1cccc(-n2nc3c(=O)[nH]nc(N)c3c2-c2oc3cc(C(=O)Nc4cccc(C(F)(F)F)c4)ccc3c2C)c1 CHEMBL5094596 IC50 42.8 nM
CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2c(Cl)c(CN3CCNCC3)c(C(F)(F)F)cc2c1=O CHEMBL3422021 IC50 43.0 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1Oc1ccc(-c2n[nH]c3ncnc(N)c23)cc1 CHEMBL4744535 IC50 44.0 nM
CN1CCN(Cc2ccc(C(=O)Nc3cccc(Oc4ccc(-c5n[nH]c6ncnc(N)c56)cc4)c3)cc2C(F)(F)F)CC1 CHEMBL4794437 IC50 44.0 nM
CC(NC(=O)c1cnc2ccccn12)c1ccc(C(=O)N[C@H](CCC2CCCCC2)C(=O)NC2CCCN(S(C)(=O)=O)C2)cc1 CHEMBL5087073 IC50 44.0 nM
CC1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(CN4CCN(C)CC4)cc(-c4ccccc4)c3)ccc21 CHEMBL4070502 IC50 44.6 nM
COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O CHEMBL1289601 Kd apparent 46.0 nM
Cc1ccc(NC(=O)c2ccc(C)c(C#Cc3cnc4ccnn4c3)c2)cc1 CHEMBL2336035 IC50 47.75 nM
Cc1ccc(-n2nc3c(=O)[nH]nc(N)c3c2-c2oc3cc(C(=O)Nc4cccc(C(F)(F)F)c4)ccc3c2C)cc1 CHEMBL5072528 IC50 49.0 nM
CC(C)c1cc(CN2CCN(C)CC2)cc(NC(=O)c2ccc3c(c2)CN(c2cncnc2)CC3C)c1 CHEMBL4091837 IC50 49.9 nM
CCc1cc(CN2CCN(C)CC2)cc(NC(=O)c2ccc3c(c2)CN(c2cncnc2)CC3C)c1 CHEMBL4064078 IC50 50.5 nM
CCc1ccc(C(=O)Nc2ccc(F)c(C(F)(F)F)c2)cc1-c1cc(C)cc(-c2cnc3cnccn23)c1 CHEMBL4438214 IC50 55.6 nM
COc1cc(CCc2cc(NC(=O)c3ccc(N4CC(C)NC(C)C4)cc3)n[nH]2)cc(OC)c1 CHEMBL3184679 Kd apparent 56.0 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O CHEMBL477772 Kd 57.0 nM
COc1cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)cc(OC(F)F)c1C(=O)NC1CC1 CHEMBL5417444 IC50 57.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL223360 Kd 58.0 nM
CN(C)c1ccc2c(Oc3ccc(NC(=O)NCc4ccc(C(F)(F)F)nc4)cc3)ncnc2c1 CHEMBL4847875 IC50 59.7 nM
Cc1c(-c2c3c(N)n[nH]c(=O)c3nn2-c2ccc(F)cc2)oc2cc(C(=O)Nc3cccc(C(F)(F)F)c3)ccc12 CHEMBL5088050 IC50 60.4 nM
C[C@@H](NC(=O)c1ncnc(N)c1Cl)c1ncc(C(=O)Nc2cc(C(F)(F)F)c(Cl)cn2)s1 CHEMBL3348923 Kd apparent 63.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-n3nc(-c4ccc(OCCN5CCOCC5)cc4)c4c(N)ncnc43)cc2)no1 CHEMBL4101411 IC50 63.0 nM
CCc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(-c2cnc3cnccn23)ccc1C CHEMBL4535081 IC50 63.7 nM
CCCCNC(=O)c1ccc(C)c(C#Cc2cnc3ccnn3c2)c1 CHEMBL2336029 IC50 65.14 nM
CC1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(CN4CCN(C)CC4)cc(C(C)(C)C)c3)ccc21 CHEMBL4077200 IC50 66.6 nM
CC(C)(c1cc(NC(=O)Nc2ccc(-c3cc(-c4ccc(OCCN5CCOCC5)cc4)[nH]n3)cc2)no1)C(F)(F)F CHEMBL5407194 IC50 66.6 nM
CCc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(-c2cnc3cnccn23)cc(C(C)C)c1 CHEMBL4590224 IC50 66.9 nM
NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)NCCCCN1CCCC1 CHEMBL253969 Kd apparent 67.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2nc(CCOCc3ccncc3)cs2)cc1 CHEMBL1738943 IC50 68.0 nM
Cc1cn(-c2cc(NC(=O)c3ccc4c(c3)C[C@H](N(C)c3cncnc3)C4)cc(C3CCCCC3)c2)cn1 CHEMBL4560079 IC50 68.7 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 CHEMBL450786 Kd 70.0 nM
CCN1CCN(Cc2ccc(C(=O)Nc3ccc(C)c(Oc4ccc(-c5n[nH]c6ncnc(N)c56)cc4)c3)cc2C(F)(F)F)CC1 CHEMBL4787932 IC50 70.0 nM
Cc1ccc2c(Nc3ccc(F)c(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12 CHEMBL3915720 IC50 71.0 nM
CCN1CCN(Cc2cc(NC(=O)c3ccc4c(c3)CN(c3cncnc3)CC4C)cc(C(F)(F)F)c2)CC1 CHEMBL4069234 IC50 71.1 nM
COc1cc2c(Nc3ccc(Cl)c(Cl)c3F)ncnc2cc1OC[C@@H]1C[C@@H]2CN(C)C[C@@H]2C1 CHEMBL3544983 Kd apparent 73.0 nM
CCc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2F)cc1-c1cc(C)cc(-c2cnc3cnccn23)c1 CHEMBL4547295 IC50 73.8 nM
C[C@H]1CN(c2cncnc2)Cc2cc(NC(=O)c3cc(CN4CCN(C)CC4)cc(C(F)(F)F)c3)ccc21 CHEMBL4088388 IC50 75.7 nM
CC1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(CN4CCN(C5CCCCC5)CC4)cc(C(F)(F)F)c3)ccc21 CHEMBL4096896 IC50 79.9 nM
CC1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(CCN4CCN(C)CC4)cc(C(F)(F)F)c3)ccc21 CHEMBL4096477 IC50 80.7 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1 CHEMBL576982 Kd 81.0 nM
CCN1CCN(Cc2ccc(C(=O)Nc3ccc(C)c(Oc4ccc5c(c4)CC(=O)N5)c3)cc2C(F)(F)F)CC1 CHEMBL3421914 IC50 86.0 nM
CC1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(CN4CCN(C)CC4)cc(C4CC4)c3)ccc21 CHEMBL4065684 IC50 89.0 nM
CCc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(-c2cnc3cnccn23)cc(C(C)(C)C)c1 CHEMBL4565522 IC50 92.0 nM
CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CCN(C)CC2)c(C(F)(F)F)c1 CHEMBL3422020 IC50 97.0 nM
CNc1ncc2c(-c3ccc(N4CCN(C)CC4)nc3)nn(CC3CCCC3)c2n1 CHEMBL4208852 IC50 100.0 nM
CCc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc(C)c(-c2cnc3cnccn23)c1 CHEMBL4470983 IC50 107.8 nM
Cc1csc(-c2nnc(Nc3ccc(Oc4ncccc4-c4ccnc(N)n4)cc3)c3ccccc23)c1 CHEMBL2140408 Kd apparent 110.0 nM
Cc1ccc(C(=O)N2CCC(Oc3cc(NC(=O)c4ccc(CN5CCN(C)CC5)c(C(F)(F)F)c4)ccc3C)CC2)cn1 CHEMBL3939150 IC50 116.0 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 120.0 nM
CC1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(CN4CCN(C)CC4)cc(C4CCCCC4)c3)ccc21 CHEMBL4083149 IC50 123.0 nM
COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c3)c2cc1OC CHEMBL2029988 Kd apparent 124.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1OC1CCN(C(=O)c2ccncc2)CC1 CHEMBL3809935 IC50 126.0 nM
Cc1cc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(Cl)cc2)ccc1Nc1ncnc2c1OC(C)(C)C(=O)N2 CHEMBL5088153 IC50 126.0 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)c(I)c2)cc1Oc1ccc(-c2n[nH]c3ncnc(N)c23)cc1 CHEMBL4787667 IC50 131.0 nM
CC1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(N4CCN(C)CC4)cc(C(F)(F)F)c3)ccc21 CHEMBL4060550 IC50 132.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(C(F)(F)F)c4)cc3)c2cc1OC CHEMBL4577779 IC50 135.0 nM
Nc1nc2cc(-c3nn(CC4CCCO4)c4ncnc(N)c34)ccc2o1 CHEMBL3797834 IC50 137.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 140.0 nM
O=C(Nc1cccc(Cl)c1)Nc1ncc(CCNc2ncnc3ccsc23)s1 CHEMBL482767 Kd apparent 140.0 nM
CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL402548 Kd apparent 142.0 nM
O=C(NCc1cccc(NC(=O)c2cnc3ccccn23)c1)Nc1ccccc1 CHEMBL3608784 IC50 150.0 nM
CCN(c1cncnc1)[C@@H]1Cc2ccc(C(=O)Nc3cc(-n4cnc(C)c4)cc(C(F)(F)F)c3)cc2C1 CHEMBL4570381 IC50 150.5 nM
CCc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1ccoc1 CHEMBL4171235 IC50 151.0 nM
Cc1cc2c(F)c(Oc3ncnn4cc(OC[C@@H](C)O)c(C)c34)ccc2[nH]1 CHEMBL377300 Kd 160.0 nM
O=C1Nc2ccccc2N/C1=C\C(=O)c1cccc2ccccc12 CHEMBL4531109 IC50 160.0 nM
Oc1cccc(Nc2ccnc3cc(-c4cccc(CN5CCOCC5)c4)sc23)c1 CHEMBL2336005 IC50 164.0 nM
CC(=O)Nc1ccc(-n2nc3c(=O)[nH]nc(N)c3c2-c2oc3cc(C(=O)Nc4ccc(C(F)(F)F)cc4)ccc3c2C)cc1 CHEMBL5084624 IC50 164.0 nM
CC1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(CN4CCCCC4)cc(C(F)(F)F)c3)ccc21 CHEMBL4087848 IC50 167.0 nM
C[C@@H]1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(CN4CCCN(C)CC4)cc(C(F)(F)F)c3)ccc21 CHEMBL4059972 IC50 167.0 nM
O=C(Nc1ccc2c(c1)Oc1ncccc1C(=O)N2c1ccncc1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL4792974 IC50 170.0 nM
Cc1ccc(C(=O)Nc2ccc(Oc3cc4cnn(C)c4cc3-c3cn[nH]c3)c(F)c2)c(=O)n1-c1ccc(F)cc1 CHEMBL3545307 Kd apparent 174.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC CHEMBL1289494 Kd apparent 190.0 nM
CC1CN(c2cncnc2)Cc2cc(C(=O)Nc3cccc(C(F)(F)F)c3)ccc21 CHEMBL4085787 IC50 191.0 nM
CC1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(CN4CCOCC4)cc(C(F)(F)F)c3)ccc21 CHEMBL4078110 IC50 193.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC CHEMBL2105717 Kd apparent 209.0 nM
CC1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(CN4CCSCC4)cc(C(F)(F)F)c3)ccc21 CHEMBL4066530 IC50 209.0 nM
CCC(=O)Nc1cc(Nc2ncc(C(=O)Nc3cc(NC(=O)c4cc(OC)c(OC)c(OC)c4)ccc3C)c(NC)n2)ccc1C CHEMBL4087478 IC50 212.0 nM
CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1 CHEMBL3545085 Kd apparent 221.0 nM
Nc1nc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)c2cc(C3=CCN(C4COC4)CC3)[nH]c2n1 CHEMBL5077961 IC50 221.0 nM
CC1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(CN4CCCC4)cc(C(F)(F)F)c3)ccc21 CHEMBL4069922 IC50 222.0 nM
CN1CCN(Cc2cc(NC(=O)c3ccc4c(c3)CN(c3cncnc3)CC4(C)C)cc(C(F)(F)F)c2)CC1 CHEMBL4068810 IC50 223.0 nM
CC(C)(C)c1cc(NC(=O)Nc2cccc(Nc3ncnc4ccccc34)c2)n(-c2cccc(N)c2)n1 CHEMBL2403875 IC50 235.0 nM
CC(=O)Nc1ccc(-n2nc3c(=O)[nH]nc(N)c3c2-c2oc3cc(C(=O)Nc4ccccc4)ccc3c2C)cc1 CHEMBL5075627 IC50 235.0 nM
Cc1nc2c(cnn2-c2csc(C(=O)NC3COC3)c2)cc1Nc1c(F)cccc1Cl CHEMBL4845770 IC50 247.0 nM
CC1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(CN(C)C)cc(C(F)(F)F)c3)ccc21 CHEMBL4086988 IC50 254.0 nM
C#CCCC1(CC(=O)N2CCN(Cc3cc(NC(=O)c4ccc5c(c4)CN(c4cncnc4)CC5C)cc(C(F)(F)F)c3)CC2)N=N1 CHEMBL4640184 IC50 258.6 nM
CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc21 CHEMBL572881 Kd 260.0 nM
C=CC(=O)Nc1cc(Nc2ncc(C(=O)Nc3cc(NC(=O)c4cc(OC)c(OC)c(OC)c4)ccc3C)c(NC)n2)ccc1C CHEMBL4066104 IC50 265.0 nM
Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 CHEMBL101253 Kd 270.0 nM
Cn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC3CCOCC3)nc21 CHEMBL1230122 Kd 270.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc4ncccc4c3)c(F)c2)ccn1 CHEMBL1738757 Kd apparent 272.0 nM
CNc1nc(Nc2ccc(C)c(N)c2)ncc1C(=O)Nc1cc(NC(=O)c2cccc(C(F)(F)F)c2)ccc1C CHEMBL3780219 IC50 292.0 nM
C[C@@H]1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(CN4CCN(C)CC4)cc(C(F)(F)F)c3)ccc21 CHEMBL4453539 IC50 309.0 nM
COCc1c(-c2ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)c(F)c2)c2c(N)ncnn2c1CN1CCOCC1 CHEMBL3991934 Kd apparent 314.0 nM
Cc1ccc(C(=O)Nc2cccc(CN3CCN(C)CC3)c2)cc1C#Cc1cnc2ccnn2c1 CHEMBL2336027 IC50 324.1 nM
Cc1cn(-c2cc(NC(=O)c3ccc4c(c3)CN(c3cncnc3)C[C@H]4C)cc(C(F)(F)F)c2)cn1 CHEMBL4471343 IC50 326.0 nM
CN1CCN(Cc2cc(NC(=O)c3ccc4c(c3)CN(c3cccnc3)CC4)cc(C(F)(F)F)c2)CC1 CHEMBL4544384 IC50 328.0 nM
CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL1289926 Kd 340.0 nM
CCc1ccc(C(=O)Nc2cccc(CN3CCN(C)CC3)c2)cc1-c1cccc(-c2cnc3cnccn23)c1 CHEMBL4544048 IC50 357.1 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1 CHEMBL1946170 Kd apparent 358.0 nM
CCc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1-c1cccc(-c2cnc3ccnn3c2)c1 CHEMBL4559959 IC50 359.5 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2cc(F)ccc2Oc2ccc3c(cnn3CCO)c2)cc1 CHEMBL3991932 Kd apparent 363.0 nM
CCCCNC(=O)c1ccc2c(C)c(-c3c4c(N)n[nH]c(=O)c4nn3-c3ccc(NC(C)=O)cc3)oc2c1 CHEMBL5083118 IC50 376.0 nM
CN1CCN(Cc2cc(NC(=O)c3ccc(C(C)(C)C)c(C#Cc4cnc5cnccn45)c3)cc(C(F)(F)F)c2)CC1 CHEMBL4164870 IC50 380.0 nM
Cc1cn(-c2cccc(NC(=O)c3ccc(C)c(C#Cc4cnc5ccnn5c4)c3)c2)cn1 CHEMBL2336026 IC50 386.5 nM
CC1CN(c2cncnc2)Cc2cc(C(=O)Nc3cc(CN4CCN(CCC(=O)NCCCNC(=O)OC5CC/C=C/CCC5)CC4)cc(C(F)(F)F)c3)ccc21 CHEMBL4637438 IC50 397.4 nM
C=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1 CHEMBL31965 Kd 400.0 nM
Cc1ccc(NC(=O)c2ccc(CN3CCOCC3)c(C(F)(F)F)c2)cc1Oc1ccc(-c2n[nH]c3ncnc(N)c23)cc1 CHEMBL4742966 IC50 416.0 nM
CN1CCN(Cc2cc(NC(=O)c3ccc4c(c3)CN(c3cncnc3)CC4)cc(C(F)(F)F)c2)CC1 CHEMBL4095191 IC50 442.0 nM
CCNC(=O)C#Cc1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN(C)C)cc1)c1ccccc1 CHEMBL3699142 Kd apparent 469.0 nM
COc1ccccc1NC(=O)c1ccc(C)c(C#Cc2cnc3ccnn3c2)c1 CHEMBL2336039 IC50 470.0 nM
c1ccc2c(-c3coc4cc(-c5ccc(N6CCNCC6)cc5)cnc34)ccnc2c1 CHEMBL5083143 IC50 501.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 510.0 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 Kd 510.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 515.0 nM
CCN1CCN(c2cc(C(=O)Nc3cccc(Nc4ccc5c(OC)cccc5n4)c3)cc(C(F)(F)F)c2)CC1 CHEMBL4795732 IC50 538.0 nM
CC1Cc2ccc(C(=O)Nc3cc(CN4CCN(C)CC4)cc(C(F)(F)F)c3)cc2CN1c1cncnc1 CHEMBL4096111 IC50 545.0 nM
COCCNCc1ccc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccc(F)cc5)cc4F)c3s2)nc1 CHEMBL3989914 Kd apparent 549.0 nM
C#CCCC1(CCN2CCN(Cc3cc(NC(=O)c4ccc5c(c4)CN(c4cncnc4)CC5C)cc(C(F)(F)F)c3)CC2)N=N1 CHEMBL4642375 IC50 576.6 nM
C[C@@H]1CN(c2cncnc2)Cc2cc(NC(=O)c3cc(CN4CCN(C)CC4)cc(C(F)(F)F)c3)ccc21 CHEMBL4060157 IC50 614.0 nM
CCc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc(N(C)C)nc1 CHEMBL4160628 IC50 614.0 nM
Cc1cc(NC(=O)c2ccc3c(c2)C[C@H](N(C)c2cncnc2)C3)cc(-n2cnc(C)c2)c1 CHEMBL4585974 IC50 638.9 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 674.0 nM
CCc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1ccsc1 CHEMBL4176591 IC50 695.0 nM
Cc1cn(-c2cc(NC(=O)c3ccc4c(c3)CC(C)(Nc3cncnc3)C4)cc(C(F)(F)F)c2)cn1 CHEMBL4443543 IC50 723.1 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 740.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(/C=C/c3ccccc3)n2)n[nH]1 CHEMBL482968 Kd apparent 755.0 nM
C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 CHEMBL553 Kd 790.0 nM
CC(=O)Nc1ccc(-n2nc3c(=O)[nH]nc(N)c3c2-c2oc3cc(C(=O)NC4CCCCC4)ccc3c2C)cc1 CHEMBL5081927 IC50 826.0 nM
Cc1nc2cc(-c3nn(C(C)C)c4ncnc(N)c34)ccc2o1 CHEMBL3991933 Kd apparent 881.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 888.0 nM
Cc1ccc(NC(=O)c2ccc(CN3CCCCC3)c(C(F)(F)F)c2)cc1Oc1ccc(-c2n[nH]c3ncnc(N)c23)cc1 CHEMBL4787522 IC50 975.0 nM
C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL10 Kd 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM