CC(n1c(=O)n(-c2cc(OC(F)F)ccc2F)c2ccc(C(=O)NC3(C)CS(=O)(=O)C3)cc21)C(C)(C)O CHEMBL5203547 IC50 0.7 nM
CC(n1c(=O)n(-c2cc(OC(F)(F)F)ccc2F)c2cc(F)c(C(=O)NC3(C)CCS(=O)(=O)CC3)cc21)C(C)(C)O CHEMBL5202996 IC50 1.0 nM
CC(n1c(=O)n(-c2cc(OC(F)F)ccc2F)c2ccc(C(=O)NC3(C)CCS(=O)(=O)CC3)cc21)C(C)(C)O CHEMBL5179522 IC50 1.1 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(n5cc(Cl)cn5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4098964 IC50 1.3 nM
CC(n1c(=O)n(-c2cc(OCC(F)F)ccc2F)c2cc(F)c(C(=O)NC3(C)CCS(=O)(=O)CC3)cc21)C(C)(C)O CHEMBL5194578 IC50 1.5 nM
CC(n1c(=O)n(-c2cccc(OC(F)F)c2)c2ccc(C(=O)NC3(C)CCS(=O)(=O)CC3)cc21)C(C)(C)O CHEMBL5188169 IC50 1.6 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(OC(F)(F)F)c4)[nH]c3n2)C1)N1CCCC1 CHEMBL4107035 IC50 1.7 nM
CC1(NC(=O)c2ccc3c(c2)n(-c2ccc(F)cc2)c(=O)n3-c2cccc(OC(F)F)c2)CS(=O)(=O)C1 CHEMBL5184213 IC50 1.8 nM
Cc1noc([C@H]2C[C@@H]2C(=O)NCc2ccc(-c3cccc(OC(F)(F)F)c3)c3c2CN(C(=O)NC(C)(C)C)CC3)n1 CHEMBL3734797 IC50 2.0 nM
CCOc1cc(F)cnc1Oc1cncc(-c2ncc(C(=O)N[C@@H]3CNCC[C@H]3F)cn2)c1 CHEMBL4868285 IC50 2.4 nM
C[C@H](c1nc2cnc(N3CCC[C@@H](C(=O)N4CCCC4)C3)nc2[nH]1)n1cc(Cl)cn1 CHEMBL4110005 IC50 2.5 nM
CC(C)Cc1csc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)n1 CHEMBL4114076 IC50 2.71 nM
O=C([C@@H]1CCCN(c2ncc3nc(C4(n5cc(Cl)cn5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4112783 IC50 2.8 nM
COc1cccc(-c2ccc(CNC(=O)[C@H]3C[C@@H]3c3nc(C)no3)c3c2CCN(C(=O)NC(C)(C)C)C3)c1 CHEMBL3734847 IC50 3.0 nM
CC(C)(C)c1csc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)n1 CHEMBL4106571 IC50 3.18 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(C5CC5)n4)[nH]c3n2)C1)N1CC=CC1 CHEMBL4114492 IC50 3.58 nM
CCOc1cc(F)cnc1Oc1cncc(-c2ncc(C(=O)N[C@H]3CNCC[C@@H]3F)cn2)c1 CHEMBL4845799 IC50 3.8 nM
COc1cccc(-c2ccc(CNC(=O)[C@@H]3C[C@H]3c3ccccc3)c3c2CCN(C(=O)NC(C)(C)C)C3)c1 CHEMBL3734764 IC50 4.0 nM
CCOc1cc(F)cnc1Oc1cncc(-c2ncc(C(=O)N[C@@H]3CNC[C@@H](F)C3)cn2)c1 CHEMBL4877520 IC50 4.1 nM
CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)N[C@H]3CC[C@@H](C(F)(F)F)NC3)cn2)c1 CHEMBL5425575 IC50 4.4 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(Cl)c4)[nH]c3n2)C1)N1CCCC1 CHEMBL4112256 IC50 4.56 nM
C[C@@H](c1nc2ccc(N3CCC[C@@H](C(=O)N4CCCC4)C3)nc2[nH]1)n1cc(Cl)cn1 CHEMBL3893203 IC50 4.6 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(-n5cccn5)c4)[nH]c3n2)C1)N1CCCC1 CHEMBL4114844 IC50 4.82 nM
CCOC(=O)C1(c2cccc(-c3nc4ccc(N5CCC[C@@H](C(=O)N6CCCC6)C5)nc4[nH]3)c2)CC1 CHEMBL4109153 IC50 5.27 nM
C[C@H](c1nc2ccc(N3CCC[C@@H](C(=O)N4CCCC4)C3)nc2[nH]1)n1cc(Cl)cn1 CHEMBL4108600 IC50 5.5 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(c5ccc(C(F)(F)F)cc5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4115482 IC50 5.68 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(C5CC5)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4112049 IC50 6.03 nM
O=C([C@@H]1CCCN(c2nc3[nH]c(-c4ccnc(C5CC5)n4)nc3cc2F)C1)N1CCCC1 CHEMBL4113426 IC50 6.32 nM
CCc1csc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)n1 CHEMBL4112999 IC50 6.47 nM
CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)NC(C)(C)CO)cn2)c1 CHEMBL5178371 IC50 6.6 nM
CC(C)c1csc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)n1 CHEMBL4115512 IC50 6.64 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4coc(-c5ccccc5)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4108326 IC50 6.85 nM
CCOC(=O)CCc1cccc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)c1 CHEMBL4112473 IC50 7.16 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(OC(F)F)c4)[nH]c3n2)C1)N1CCCC1 CHEMBL4112953 IC50 7.41 nM
C[C@@H](c1nc2cnc(N3CCC[C@@H](C(=O)N4CCCC4)C3)nc2[nH]1)n1cc(Cl)cn1 CHEMBL3894990 IC50 7.8 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(N5CCCC5)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4114546 IC50 7.81 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(n5cc(F)cn5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4110807 IC50 7.9 nM
CCOc1ccccc1O[C@@H]1CCCN(c2ncc(C(=O)NC(C)(C)CO)cn2)C1 CHEMBL5190860 IC50 7.9 nM
Cc1cccc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)c1 CHEMBL4113506 IC50 8.24 nM
O=C([C@@H]1CCCN(c2ncc3nc(C4(n5cc(F)cn5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4112762 IC50 8.9 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4ccnc(C5CCC5)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4113194 IC50 9.21 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(C(F)(F)F)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4112343 IC50 9.23 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(n5cc(C(F)(F)F)cn5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4114952 IC50 9.4 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4nc(C5CC5)cs4)[nH]c3n2)C1)N1CCCC1 CHEMBL4107221 IC50 9.55 nM
CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)N[C@@H]3CNC[C@@H](F)C3)cn2)c1 CHEMBL4875314 IC50 10.0 nM
O=C([C@@H]1CCCN(c2ncc3nc(-c4cccc(C(F)(F)F)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4111916 IC50 10.5 nM
O=C([C@@H]1CCCN(c2ccc3nc(COc4ccc(Cl)cc4)[nH]c3n2)C1)N1CCCC1 CHEMBL4113618 IC50 10.7 nM
O=C([C@H]1CN(c2ccc3nc(C4(n5cc(Cl)cn5)CC4)[nH]c3n2)CCO1)N1CCCC1 CHEMBL4112275 IC50 10.7 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(C(F)F)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4109197 IC50 10.9 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(-c5cnco5)c4)[nH]c3n2)C1)N1CCCC1 CHEMBL4108722 IC50 11.5 nM
CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)NC3CCCOC3)cn2)c1 CHEMBL5176366 IC50 11.5 nM
COc1cccc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)n1 CHEMBL4110880 IC50 12.6 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(OC(F)F)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4115600 IC50 14.3 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(C5CC5)n4)[nH]c3n2)C1)N1CCC(F)(F)C1 CHEMBL4111585 IC50 15.2 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(c5ccccn5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4107229 IC50 15.8 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4ccnc(C5CC5)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4113893 IC50 15.9 nM
CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)N[C@@H]3CNCC[C@@H]3F)cn2)c1 CHEMBL4867621 IC50 16.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cncc(Cl)c4)[nH]c3n2)C1)N1CCCC1 CHEMBL4115576 IC50 16.3 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(n5cc(Cl)cn5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4278523 IC50 17.0 nM
CCOc1cccnc1Cc1cncc(-c2ncc(C(=O)N[C@H]3CCOC3)cn2)c1 CHEMBL4456029 IC50 17.0 nM
CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)N[C@H]3CCOC3)cn2)c1 CHEMBL4760665 IC50 17.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(n5cc(Cl)cn5)CC4)[nH]c3n2)C1)N1CC=CC1 CHEMBL4111278 IC50 18.9 nM
CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)N[C@@H]3CNCC(F)(F)C3)cn2)c1 CHEMBL4873964 IC50 20.0 nM
COc1cccc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)c1 CHEMBL4107041 IC50 20.7 nM
CNS(=O)(=O)c1cccc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)c1 CHEMBL4108255 IC50 21.1 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(F)c4)[nH]c3n2)C1)N1CCCC1 CHEMBL4114945 IC50 21.2 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(N5CCC5)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4109736 IC50 21.5 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cnn(-c5ccccc5)c4)[nH]c3n2)C1)N1CCCC1 CHEMBL4109777 IC50 22.1 nM
CN(C)c1cccc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)n1 CHEMBL4112322 IC50 22.2 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4ccc(OC(F)(F)F)cc4)[nH]c3n2)C1)N1CCCC1 CHEMBL4110253 IC50 24.8 nM
O=C([C@H]1CN(c2ccc3nc(-c4cccc(C5CC5)n4)[nH]c3n2)CCO1)N1CCCC1 CHEMBL4111041 IC50 24.8 nM
N#Cc1cnn(C2(c3nc4ccc(N5CCC[C@@H](C(=O)N6CCCC6)C5)nc4[nH]3)CC2)c1 CHEMBL4110541 IC50 25.1 nM
CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)NC3(CO)CCOC3)cn2)c1 CHEMBL5172773 IC50 25.5 nM
CC(c1nc2cnc(N3CCC[C@@H](C(=O)N4CCCC4)C3)nc2[nH]1)n1cc(Cl)cn1 CHEMBL4280459 IC50 26.0 nM
O=C([C@@H]1CCCN(c2ncc3nc(-c4ccnc(C5CC5)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4108006 IC50 28.2 nM
CCOC(=O)c1cc(CC)nc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)c1 CHEMBL4110443 IC50 28.9 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4ccnc(N5CCCC5)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4113042 IC50 29.2 nM
CC(C)(c1nc2ccc(N3CCC[C@@H](C(=O)N4CCCC4)C3)nc2[nH]1)n1cc(Cl)cn1 CHEMBL4115123 IC50 31.0 nM
CCOc1cccnc1O[C@@H]1CCCN(c2ncc(C(=O)NC(C)(C)CO)cn2)C1 CHEMBL5207410 IC50 31.8 nM
CSc1cnn(C2(c3nc4ccc(N5CCC[C@@H](C(=O)N6CCCC6)C5)nc4[nH]3)CC2)c1 CHEMBL4108716 IC50 34.1 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4ccnc(C5CC5)n4)[nH]c3n2)C1)N1CCC(F)(F)C1 CHEMBL4107277 IC50 34.4 nM
N#Cc1cccc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)c1 CHEMBL4108794 IC50 34.5 nM
Cc1csc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)n1 CHEMBL4115249 IC50 35.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4ccnc(C5CC5)n4)[nH]c3n2)C1)N1CC[C@@H](F)C1 CHEMBL4114554 IC50 35.4 nM
CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)NC(C)(C)CS(C)(=O)=O)cn2)c1 CHEMBL5188261 IC50 35.4 nM
Cc1cccc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)n1 CHEMBL4108000 IC50 36.5 nM
CCOC(=O)c1cc(OC)nc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)c1 CHEMBL4109323 IC50 37.3 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cncc(C5CC5)c4)[nH]c3n2)C1)N1CCCC1 CHEMBL4109385 IC50 37.5 nM
COC(=O)Cc1cccc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)c1 CHEMBL4113012 IC50 41.5 nM
CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)N[C@H]3CNC[C@H](F)C3)cn2)c1 CHEMBL5405419 IC50 42.0 nM
CN(C)C(=O)[C@@H]1CCCN(c2ccc3nc(-c4cccc(C5CC5)n4)[nH]c3n2)C1 CHEMBL4108080 IC50 47.3 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(c5cccnc5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4109229 IC50 47.7 nM
CNS(=O)(=O)c1cncc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)c1 CHEMBL4113043 IC50 47.8 nM
COC(=O)c1cccc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)c1 CHEMBL4107187 IC50 54.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc5ccnn45)[nH]c3n2)C1)N1CCCC1 CHEMBL4106957 IC50 54.7 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4ccnc(C5CC5)n4)[nH]c3n2)C1)N1C[C@@H](F)[C@H](F)C1 CHEMBL4111728 IC50 54.7 nM
C[C@@H]1CCCN1C(=O)[C@@H]1CCCN(c2ccc3nc(-c4ccnc(C5CC5)n4)[nH]c3n2)C1 CHEMBL4109549 IC50 58.2 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4ccnc(C5CC5)n4)[nH]c3n2)C1)N1CC[C@H](F)C1 CHEMBL4113053 IC50 59.3 nM
COc1cccc(-c2ccc(CNC(=O)[C@@H]3C[C@H]3c3ccccc3)c3c2CCN(C(=O)OC(C)(C)C)C3)c1 CHEMBL3735235 IC50 60.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cncc(C5CC5)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4109929 IC50 60.5 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(C5(O)CC5)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4108495 IC50 62.3 nM
N#Cc1ccc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)cc1 CHEMBL4112678 IC50 63.6 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4ccccc4)[nH]c3n2)C1)N1CCCC1 CHEMBL4111459 IC50 66.2 nM
CC(C)(O)c1cccc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)n1 CHEMBL4114096 IC50 67.9 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(c5ccccc5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4113076 IC50 69.7 nM
O=C([C@@H]1CCCN(c2cnc3nc(-c4ccnc(C5CC5)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4111437 IC50 71.6 nM
O=C([C@H]1CN(c2ccc3nc(-c4cccc(C(F)F)n4)[nH]c3n2)CCO1)N1CCCC1 CHEMBL4107196 IC50 71.7 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4nccc(C5CC5)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4108299 IC50 72.5 nM
CC(C)(O)c1cc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)ccn1 CHEMBL4109903 IC50 72.8 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4ccnc(C5CC5)n4)[nH]c3n2)C1)N1CC(F)(F)C1 CHEMBL4112665 IC50 73.4 nM
Cc1ccc(C2(c3nc4ccc(N5CCC[C@@H](C(=O)N6CCCC6)C5)nc4[nH]3)CC2)cc1 CHEMBL4108733 IC50 73.7 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(n5cc(Cl)cn5)CC4)[nH]c3n2)C1)N1CC(F)(F)C1 CHEMBL4114023 IC50 74.2 nM
Cc1nc(C)c(-c2ccc(C3CCC(CC(=O)O)CC3)cc2)nc1C(N)=O CHEMBL4297354 IC50 80.0 nM
C[C@@H]1CC[C@@H](C(=O)N2CCCC2)CN1c1ncc2nc(C3(n4cc(Cl)cn4)CC3)[nH]c2n1 CHEMBL4111752 IC50 82.8 nM
NC(=O)c1cccc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)n1 CHEMBL4113825 IC50 83.0 nM
CCNC(=O)c1cnc(-c2cncc(Oc3ncccc3OCC)c2)nc1 CHEMBL5176043 IC50 84.6 nM
CC(C)COC(=O)N1CCCC(c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)C1 CHEMBL4109893 IC50 86.4 nM
CC(c1nc2ccc(N3CCC[C@@H](C(=O)N4CCCC4)C3)nc2[nH]1)n1cccn1 CHEMBL4113044 IC50 86.8 nM
C[C@@H](c1nc2ccc(N3CCC[C@@H](C(=O)N4CCCC4)C3)nc2[nH]1)n1cc(F)cn1 CHEMBL3930155 IC50 88.6 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4ccnc(NC5CC5)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4108726 IC50 89.6 nM
NS(=O)(=O)c1cccc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)c1 CHEMBL4108068 IC50 90.3 nM
C[C@@H]1CCCN1C(=O)[C@@H]1CCCN(c2ccc3nc(C4(n5cc(Cl)cn5)CC4)[nH]c3n2)C1 CHEMBL4114906 IC50 91.0 nM
CCOc1ccccc1O[C@@H]1CCCN(c2ncc(C(=O)NCc3cccc(C(=O)O)c3)cn2)C1 CHEMBL5179535 IC50 91.8 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cc(C5CC5)ccn4)[nH]c3n2)C1)N1CCCC1 CHEMBL4115637 IC50 94.4 nM
Cc1cccc(C2(c3nc4ccc(N5CCC[C@@H](C(=O)N6CCCC6)C5)nc4[nH]3)CC2)c1 CHEMBL4114201 IC50 96.9 nM
Cc1cncc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)c1 CHEMBL4107286 IC50 97.0 nM
COc1cccc(C2(c3nc4ccc(N5CCC[C@@H](C(=O)N6CCCC6)C5)nc4[nH]3)CC2)c1 CHEMBL4107636 IC50 99.6 nM
COc1cnn(C2(c3nc4ccc(N5CCC[C@@H](C(=O)N6CCCC6)C5)nc4[nH]3)CC2)c1 CHEMBL4108647 IC50 101.0 nM
N#Cc1cncc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)c1 CHEMBL4113402 IC50 102.0 nM
Cc1cc(C2(c3nc4ccc(N5CCC[C@@H](C(=O)N6CCCC6)C5)nc4[nH]3)CC2)no1 CHEMBL4108044 IC50 102.0 nM
Cc1cnn(C2(c3nc4ccc(N5CCC[C@@H](C(=O)N6CCCC6)C5)nc4[nH]3)CC2)c1 CHEMBL4111571 IC50 104.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(n5cc(C6CC6)cn5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4109528 IC50 107.0 nM
COc1ccc(C2(c3nc4ccc(N5CCC[C@@H](C(=O)N6CCCC6)C5)nc4[nH]3)CC2)cc1 CHEMBL4110457 IC50 107.0 nM
CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)N[C@@H]3CNCC[C@H]3F)cn2)c1 CHEMBL5423297 IC50 110.0 nM
CCCS(=O)(=O)N1CCCC(c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)C1 CHEMBL4110483 IC50 113.0 nM
Cc1nc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)cs1 CHEMBL4113634 IC50 118.0 nM
COC(=O)c1cccc(-c2ccc(CNC(=O)Nc3cccc(Cl)c3Cl)c3cnccc23)c1 CHEMBL3736062 IC50 120.0 nM
O=C(C1CCCC1)N1CCC(c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)CC1 CHEMBL4108750 IC50 122.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(Cc5ccccc5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4115624 IC50 128.0 nM
C[C@H](c1nc2ccc(N3CCC[C@@H](C(=O)N4CCCC4)C3)nc2[nH]1)n1cc(F)cn1 CHEMBL4108951 IC50 128.0 nM
C[C@@H]1CC[C@@H](C(=O)N2CCCC2)CN1c1ccc2nc(C3(n4cc(Cl)cn4)CC3)[nH]c2n1 CHEMBL4110625 IC50 131.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cncc(F)c4)[nH]c3n2)C1)N1CCCC1 CHEMBL4112367 IC50 137.0 nM
COC(=O)c1cccc(-c2ccc(CNC(=O)[C@@H]3C[C@H]3c3ccccc3)c3ccccc23)c1 CHEMBL3736485 IC50 140.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(c5coc(C6CC6)n5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4107655 IC50 142.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cncc(C5CC5)n4)[nH]c3n2)C1)N1CCOCC1 CHEMBL4107539 IC50 153.0 nM
c1cc(-c2nc3ccc(N4CCC[C@H](c5nnc6n5CCC6)C4)nc3[nH]2)nc(C2CC2)c1 CHEMBL3963685 IC50 161.0 nM
O=C([C@H]1CN(c2ncc3nc(C4(n5cc(Cl)cn5)CC4)[nH]c3n2)CCO1)N1CCCC1 CHEMBL4110539 IC50 161.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4ccnc(C5CC5)n4)[nH]c3n2)C1)N1CCOCC1 CHEMBL4108613 IC50 162.0 nM
O=C([C@H]1CN(c2ccc3nc(-c4cccc(C5CC5)n4)[nH]c3n2)CCO1)N1CCOCC1 CHEMBL4109404 IC50 162.0 nM
Cc1oc(C2CC2)nc1Cc1nc2ccc(N3CCC[C@@H](C(=O)N4CCCC4)C3)nc2[nH]1 CHEMBL4107320 IC50 166.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(c5cnccn5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4107534 IC50 176.0 nM
COc1cccc(-c2ccc(CNC(=O)C3CC34CCCCC4)c3cnccc23)c1 CHEMBL3735758 IC50 180.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cncc(C(F)(F)F)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4115555 IC50 187.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(Cc4ccc(Cl)cc4)[nH]c3n2)C1)N1CCCC1 CHEMBL4106928 IC50 188.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(n5cc(Cl)cn5)CC4)[nH]c3n2)C1)N1CCC1 CHEMBL4106849 IC50 188.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(c5cccnc5)CCC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4112888 IC50 190.0 nM
Cn1nccc1C1(c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)CC1 CHEMBL4108463 IC50 190.0 nM
O=C([C@@H]1CCCN(c2ccc3nc([C@H]4C[C@H]4c4ccccc4)[nH]c3n2)C1)N1CCCC1 CHEMBL4109255 IC50 196.0 nM
CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)NC3CCS(=O)(=O)C3)cn2)c1 CHEMBL5183303 IC50 196.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4Cc5ccccc5C4)[nH]c3n2)C1)N1CCCC1 CHEMBL4115256 IC50 197.0 nM
CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)N[C@@H]3CCOC3)cn2)c1 CHEMBL5202498 IC50 200.0 nM
CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)N[C@@H]3CNC[C@H](F)C3)cn2)c1 CHEMBL5394885 IC50 200.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(c5ccon5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4108196 IC50 202.0 nM
CC(C)(O)c1csc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)n1 CHEMBL4112145 IC50 207.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4ccc5nccn5c4)[nH]c3n2)C1)N1CCCC1 CHEMBL4112602 IC50 208.0 nM
c1cc(-c2nc3ccc(N4CCC[C@@H](c5ncc6n5CCC6)C4)nc3[nH]2)nc(C2CC2)n1 CHEMBL4107583 IC50 210.0 nM
CC(c1ccccc1)c1nc2ccc(N3CCC[C@@H](C(=O)N4CCCC4)C3)nc2[nH]1 CHEMBL4110367 IC50 211.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(c5ccncc5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4114421 IC50 218.0 nM
Cn1cc(Cl)c(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)n1 CHEMBL4108916 IC50 221.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(n5cccn5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4113118 IC50 230.0 nM
CCN(C)C(=O)[C@@H]1CCCN(c2ccc3nc(-c4ccnc(C5CC5)n4)[nH]c3n2)C1 CHEMBL4115059 IC50 231.0 nM
CS(=O)(=O)c1cccc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)c1 CHEMBL4114028 IC50 235.0 nM
CCc1cc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)no1 CHEMBL4108174 IC50 239.0 nM
O=C(C1CCCC1)N1CCCC(c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)C1 CHEMBL4111596 IC50 241.0 nM
COc1ccccc1C1(c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)CC1 CHEMBL4112324 IC50 242.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(n5cc(Cl)cn5)CC4)[nH]c3n2)C1)N1CCOCC1 CHEMBL4110809 IC50 246.0 nM
c1cc(-c2nc3ccc(N4CCCC(c5ncc6n5CCC6)C4)nc3[nH]2)nc(C2CC2)n1 CHEMBL3950553 IC50 252.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4ccnc(C5CC5)n4)[nH]c3n2)C1)N1CCC1 CHEMBL4111132 IC50 270.0 nM
N#CC1(c2cccc(-c3nc4ccc(N5CCC[C@@H](C(=O)N6CCCC6)C5)nc4[nH]3)n2)CC1 CHEMBL4112235 IC50 275.0 nM
COC(=O)c1cccc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)n1 CHEMBL4108192 IC50 276.0 nM
Clc1cccc(-c2nc3ccc(N4CCO[C@H](c5ccccn5)C4)nc3[nH]2)c1 CHEMBL3954058 IC50 285.0 nM
CC(C)(C)OCc1nc2ccc(N3CCC[C@@H](C(=O)N4CCCC4)C3)nc2[nH]1 CHEMBL4107853 IC50 286.0 nM
Cc1cc(C2(c3nc4ccc(N5CCC[C@@H](C(=O)N6CCCC6)C5)nc4[nH]3)CC2)on1 CHEMBL4106648 IC50 288.0 nM
CN(CC1CC1)C(=O)[C@@H]1CCCN(c2ccc3nc(-c4ccnc(C5CC5)n4)[nH]c3n2)C1 CHEMBL4113001 IC50 290.0 nM
c1cc(-c2nc3ccc(N4CCCC(c5nnc6n5CCC6)C4)nc3[nH]2)nc(C2CC2)c1 CHEMBL3963076 IC50 292.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4ccnc(N5CCOCC5)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4113476 IC50 297.0 nM
COc1cccc(-c2ccc(CNC(=O)[C@@H]3C[C@H]3c3ccccc3)c3ncccc23)c1 CHEMBL3736366 IC50 300.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4coc(C5CC5)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4109291 IC50 301.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(c5cncnc5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4107057 IC50 312.0 nM
Cc1ccnn1C1(c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)CC1 CHEMBL4110671 IC50 315.0 nM
C[C@H]1CCCN1C(=O)[C@@H]1CCCN(c2ccc3nc(C4(n5cc(Cl)cn5)CC4)[nH]c3n2)C1 CHEMBL3909393 IC50 321.0 nM
O=C([C@@H]1CCCN(c2ncc3nc(C4(n5cccn5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4108476 IC50 342.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4ccccc4F)[nH]c3n2)C1)N1CCCC1 CHEMBL4112431 IC50 346.0 nM
CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)NC3CCOCC3)cn2)c1 CHEMBL5171697 IC50 353.0 nM
CC(C)(c1ccccc1)c1nc2ccc(N3CCC[C@@H](C(=O)N4CCCC4)C3)nc2[nH]1 CHEMBL4110905 IC50 357.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(n5nccn5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4114566 IC50 396.0 nM
O=C([C@H]1CN(c2ccc3nc(-c4cncc(C5CC5)n4)[nH]c3n2)CCO1)N1CCCC1 CHEMBL4115165 IC50 401.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(Cc4cccc(Cl)c4)[nH]c3n2)C1)N1CCCC1 CHEMBL4114868 IC50 409.0 nM
CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)N[C@@H]3CCNC3)cn2)c1 CHEMBL5408882 IC50 410.0 nM
FC(F)Oc1cccc(-c2nc3ccc(N4CCO[C@H](c5ccccn5)C4)nc3[nH]2)c1 CHEMBL3963923 IC50 411.0 nM
CC(C)c1cccc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)c1O CHEMBL4112021 IC50 432.0 nM
Cc1cc(N2CCC[C@@H](C(=O)N3CCCC3)C2)nc2[nH]c(-c3ccnc(C4CC4)n3)nc12 CHEMBL4115013 IC50 434.0 nM
C[C@@H]1CCN(c2ccc3nc(-c4cccc(OC(F)F)c4)[nH]c3n2)C[C@@H]1C(=O)N(C)C CHEMBL4110075 IC50 434.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(Cc4ccccc4Cl)[nH]c3n2)C1)N1CCCC1 CHEMBL4112631 IC50 460.0 nM
CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)N[C@@H]3CNCCC3(F)F)cn2)c1 CHEMBL5403019 IC50 480.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(n5ccnc5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4107414 IC50 483.0 nM
COc1cccc(-c2ccc(NC(=O)[C@@H]3C[C@H]3c3nc(C)no3)c3cnccc23)c1 CHEMBL3735591 IC50 500.0 nM
CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)N[C@H]3CCNC3)cn2)c1 CHEMBL5415392 IC50 500.0 nM
CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)NC3CC(=O)N(C)C3)cn2)c1 CHEMBL5173066 IC50 501.0 nM
O=C([C@H]1CN(c2ccc3nc(-c4cccc(C(F)(F)F)n4)[nH]c3n2)CCO1)N1CCCC1 CHEMBL4107306 IC50 511.0 nM
CS(=O)(=O)c1cncc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)c1 CHEMBL4107032 IC50 512.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(c5cccnn5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4113662 IC50 531.0 nM
COc1cccc(-c2ccc(CNC(=O)Nc3cccc(Cl)c3Cl)c3cnccc23)c1 CHEMBL3736092 IC50 540.0 nM
Cc1ccn(C2(c3nc4ccc(N5CCC[C@@H](C(=O)N6CCCC6)C5)nc4[nH]3)CC2)n1 CHEMBL4113729 IC50 546.0 nM
CN1CCN(c2nc(CNc3ncc(Cl)cn3)cc(Oc3ccc(CS(N)(=O)=O)cc3)n2)CC1 CHEMBL4530491 IC50 579.0 nM
COc1cccc(-c2ccc(CNC(=O)[C@@H]3C[C@H]3c3ccccc3)c3cnccc23)c1 CHEMBL3734770 IC50 600.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(C4(c5ncccn5)CC4)[nH]c3n2)C1)N1CCCC1 CHEMBL4112996 IC50 656.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4ccnc(C5CC5)n4)[nH]c3n2)C1)N1CC[C@H](O)C1 CHEMBL4107546 IC50 695.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(C5(O)COC5)n4)[nH]c3n2)C1)N1CCCC1 CHEMBL4115070 IC50 697.0 nM
Cc1cccc(=O)n1Cc1nc2ccc(N3CCC[C@@H](C(=O)N4CCCC4)C3)nc2[nH]1 CHEMBL4114565 IC50 702.0 nM
C[C@@H]1CCN(c2ncc3nc(C4(n5cccn5)CC4)[nH]c3n2)C[C@@H]1C(=O)N1CCCC1 CHEMBL4107225 IC50 702.0 nM
CC(C)(C)c1nc2ccc(N3CCC[C@@H](C(=O)N4CCCC4)C3)nc2[nH]1 CHEMBL4112831 IC50 731.0 nM
N#Cc1ccc(Cc2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)cc1 CHEMBL4110393 IC50 764.0 nM
O=C([C@@H]1CCCN(c2ccc3nc(-c4nccc(C5CC5)n4)[nH]c3n2)C1)N1CCOCC1 CHEMBL4107653 IC50 766.0 nM
O=C(Nc1ccc(C(F)(F)F)nc1)c1nc2ccc(N3CCC[C@@H](C(=O)N4CCCC4)C3)nc2[nH]1 CHEMBL4110844 IC50 845.0 nM
c1ccc(C2CCCN(c3ccc4nc(-c5ccnc(C6CC6)n5)[nH]c4n3)C2)nc1 CHEMBL3930457 IC50 858.0 nM
CN(C)C(=O)[C@@H]1CCCN(c2ccc3nc(-c4cccc(OC(F)F)c4)[nH]c3n2)C1 CHEMBL4111552 IC50 892.0 nM
C[C@H]1CO[C@@H](c2ccccn2)CN1c1ccc2nc(-c3cccc(Cl)c3)[nH]c2n1 CHEMBL3951872 IC50 953.0 nM
N#Cc1cccc(Cc2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)c1 CHEMBL4113602 IC50 974.0 nM