Nc1nc(N)c2cc(CNc3ccc(C(=O)NC(CCCNC(=O)c4ccccc4C(=O)O)C(=O)O)cc3)ccc2n1 CHEMBL297088 Ki 1.4e-05 nM
Cc1c(CNc2ccc(C(=O)NC(CCCNC(=O)c3ccccc3C(=O)O)C(=O)O)cc2)ccc2nc(N)nc(N)c12 CHEMBL149218 Ki 0.0001 nM
Nc1nc(N)c2c(Cl)c(CNc3ccc(C(=O)NC(CCCNC(=O)c4ccccc4C(=O)O)C(=O)O)cc3)ccc2n1 CHEMBL146917 Ki 0.00011 nM
Nc1nc(N)c2nc(CNc3ccc(C(=O)NC(CCCNC(=O)c4ccccc4C(=O)O)C(=O)O)cc3)ccc2n1 CHEMBL149164 Ki 0.00019 nM
Nc1cc(N)c2cc(CCc3ccc(C(=O)NC(CCCNC(=O)c4ccccc4C(=O)O)C(=O)O)cc3)ccc2c1 CHEMBL297558 Ki 0.00021 nM
CCC(CC)n1c(C)cc2c3c(N)nc(N)nc3ccc21 CHEMBL170758 Ki 0.0003 nM
Nc1cc(N)c2nc(CNc3ccc(C(=O)NC(CCCNC(=O)c4ccccc4C(=O)O)C(=O)O)cc3)cnc2c1 CHEMBL296545 Ki 0.00033 nM
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 CHEMBL34259 Ki 0.00034 nM
Nc1nc(N)c2nc(CNc3ccc(C(=O)NC(CCCNC(=O)c4ccccc4C(=O)O)C(=O)O)cc3)cnc2n1 CHEMBL18155 Ki 0.00035 nM
Nc1cc(N)c2nc(CCc3ccc(C(=O)NC(CCCNC(=O)c4ccccc4C(=O)O)C(=O)O)cc3)cnc2c1 CHEMBL47689 Ki 0.00035 nM
Cc1c(CNc2ccc(C(=O)NC(CCCNC(=O)c3ccccc3C(=O)O)C(=O)O)cc2)cnc2nc(N)nc(N)c12 CHEMBL150607 Ki 0.0004 nM
Nc1nc(N)c2cc(CNc3ccc(C(=O)NC(CCCNC(=O)c4ccccc4C(=O)O)C(=O)O)cc3)cnc2n1 CHEMBL149962 Ki 0.00041 nM
C#CCC(Cc1cnc2cc(N)cc(N)c2n1)c1ccc(C(=O)NC(CCCNC(=O)c2ccccc2C(=O)O)C(=O)O)cc1 CHEMBL47919 Ki 0.0006 nM
CCC(Cc1cnc2cc(N)cc(N)c2n1)c1ccc(C(=O)NC(CCCNC(=O)c2ccccc2C(=O)O)C(=O)O)cc1 CHEMBL295859 Ki 0.00062 nM
Nc1nc(N)c2cc(CNc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)ccc2n1 CHEMBL305177 Ki 0.00089 nM
Nc1nc(N)c2nc(CNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cnc2n1 CHEMBL376180 Ki 0.0018 nM
Nc1nc(N)c2cc(CNc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)c4ccccc34)cnc2n1 CHEMBL132142 IC50 0.0021 nM
Nc1ncc(CCCCc2ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc2)c(N)n1 CHEMBL145947 Ki 0.005 nM
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC CHEMBL22 Ki 0.006 nM
C#CCC(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 CHEMBL1201746 Ki 0.0134 nM
COc1ccc(OC)c(Cc2cnc3nc(N)nc(N)c3c2C)c1 CHEMBL7492 Ki 0.025 nM
Nc1nc(N)c2nc(CNc3ccc4c(c3)CN([C@@H](CCC(=O)O)C(=O)O)C4=O)cnc2n1 CHEMBL390990 Ki 0.034 nM
COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC CHEMBL119 Ki 0.04 nM
Nc1nc(N)c2nc(CNc3ccc4c(c3)CN(C(CCC(=O)O)C(=O)O)C4=O)cnc2n1 CHEMBL388501 Ki 0.077 nM
CCc1cc2c3c(N)nc(N)nc3ccc2n1C(C)(C)C CHEMBL369258 Ki 0.1 nM
CCC(CC)n1c(C(C)C)cc2c3c(N)nc(N)nc3ccc21 CHEMBL171765 Ki 0.1 nM
CCc1cc2c3c(N)nc(N)nc3ccc2n1C(C)CC CHEMBL170760 Ki 0.1 nM
CC1=C2C(=O)NC(N)N=C2N(CC(C)C)C=C1 CHEMBL135937 Kd 0.1 nM
Nc1nc(N)c2nc(CN(CCCC(=O)O)c3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)cnc2n1 CHEMBL35364 Ki 0.107 nM
Nc1ncc(CCCc2ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc2)c(N)n1 CHEMBL443763 Ki 0.12 nM
Nc1nc(N)c2nc(CN(CCCCC(=O)O)c3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)cnc2n1 CHEMBL284943 Ki 0.131 nM
Nc1nc(N)c2nc(CN(CCCCCC(=O)O)c3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)cnc2n1 CHEMBL35427 Ki 0.183 nM
CC(C)n1c(C(C)(C)C)cc2c3c(N)nc(N)nc3ccc21 CHEMBL170837 Ki 0.2 nM
CCc1cc2c3c(N)nc(N)nc3ccc2n1C(CC)CC CHEMBL352960 Ki 0.2 nM
C[C@](CCC(=O)O)(NC(=O)c1ccc(CCC2CNc3nc(N)nc(N)c3C2)cc1)C(=O)O CHEMBL354249 Ki 0.29 nM
Nc1nc(N)c2c(OCc3ccccc3F)cccc2n1 CHEMBL251427 IC50 0.39 nM
CCC(C)(C)n1c(C)cc2c3c(N)nc(N)nc3ccc21 CHEMBL424170 Ki 0.4 nM
CCCc1cc2c3c(N)nc(N)nc3ccc2n1C(CC)CC CHEMBL171494 Ki 0.4 nM
CCCN1C(C)=CC=C2C(=O)NC(N)N=C21 CHEMBL135581 Kd 0.5 nM
Nc1nc(N)c2c(CNc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)cccc2n1 CHEMBL162476 Ki 0.54 nM
C[C@](CCC(=O)O)(NC(=O)c1ccc(CCC2CNc3nc(N)nc(N)c3C2)s1)C(=O)O CHEMBL168069 Ki 0.69 nM
C/C=C/c1cc(Cc2cnc(N)nc2N)cc(/C=C/C)c1OC CHEMBL301030 Ki 0.8 nM
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@H](C[C@@H](F)C(=O)O)C(=O)O)cc1 CHEMBL349572 IC50 0.84 nM
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NC(CCCN)C(=O)O)cc1 CHEMBL36083 IC50 1.0 nM
Nc1nc(N)c2c(ccc3[nH]ccc32)n1 CHEMBL353764 Ki 1.0 nM
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NC(CC(F)(F)CN)C(=O)O)cc1 CHEMBL83644 IC50 1.3 nM
CC(=O)C1=C(C)N=C(SCCC(=O)O)NC1c1ccccc1 CHEMBL2261432 IC50 1.3 nM
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NC(C(=O)O)C(F)(F)CC(=O)O)cc1 CHEMBL160699 IC50 1.34 nM
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NC(CC(F)C(=O)O)C(=O)O)cc1 CHEMBL160505 IC50 1.35 nM
COc1cc(Cc2cnc3nc(N)nc(N)c3c2C)cc(OC)c1 CHEMBL38053 IC50 1.5 nM
CCc1nc(N)nc(N)c1-c1cccc(Cl)c1 CHEMBL278847 Ki 1.6 nM
Nc1nc(N)c2c(/C=C/c3ccccc3)cccc2n1 CHEMBL164845 Ki 1.8 nM
Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc2c1C(=O)O CHEMBL38434 IC50 1.8 nM
Cc1c(CNc2ccc(Cl)c3ccccc23)cnc2nc(N)nc(N)c12 CHEMBL150317 IC50 2.0 nM
CSc1c2n(c3cc(Cl)ccc13)CCN(Cc1cnc(N)nc1N)C2 CHEMBL74592 IC50 2.0 nM
Cc1nc2ccc(Nc3nc(NCCN4CCOCC4)nc(Nc4ccc(F)cc4)n3)cc2n1Cc1ccccc1 CHEMBL3747216 IC50 2.0 nM
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc2c(c1)CN([C@@H](CCC(=O)O)C(=O)O)C2=O CHEMBL224946 Ki 2.1 nM
CCCN1C=CC=C2C(=O)NC(N)N=C21 CHEMBL135811 Kd 2.6 nM
CCC(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 CHEMBL296373 IC50 2.6 nM
NC1=NC2(CCCC2)N(OCCCCOc2cccc(C(=O)/C=C/c3ccccc3)c2)C(N)=N1 CHEMBL4091106 IC50 2.6 nM
COc1ccc(C(F)(F)F)cc1NCc1cnc2nc(N)nc(N)c2c1C CHEMBL281648 IC50 2.7 nM
Cc1cc(Cl)ccc1NCc1cnc2nc(N)nc(N)c2c1C CHEMBL150470 IC50 2.8 nM
COc1cc2c(c3c1OCO3)[C@@H](C)N(Cc1cnc(N)nc1N)CC2 CHEMBL310468 IC50 2.8 nM
Nc1nc(N)c2c(CCc3ccccc3)cccc2n1 CHEMBL341703 Ki 2.9 nM
Cc1cc2nc(-c3nccs3)n(-c3cc4nc(N)nc(N)c4cc3C)c2cc1C CHEMBL3128013 Ki 2.9 nM
NCCCC(NC(=O)c1ccc(NCc2ccc3nc(N)nc(N)c3c2Cl)cc1)C(=O)O CHEMBL38937 I50 3.0 nM
Cc1c(CNc2cc(C(F)(F)F)ccc2Br)cnc2nc(N)nc(N)c12 CHEMBL151674 IC50 3.2 nM
CC1(C)N=C(N)N=C(N)N1OCCCOc1cccc(/C=C/C(=O)c2ccccc2)c1 CHEMBL4071967 IC50 3.2 nM
CC1(C)N=C(N)N=C(N)N1OCCCCOc1ccc(C(=O)/C=C/c2ccccc2)cc1 CHEMBL4098945 IC50 3.4 nM
CCCCOc1cccc(Cc2cnc(N)nc2N)c1 CHEMBL31946 Ki 3.6 nM
CCc1c(CNc2cc(C(F)(F)F)ccc2OC)cnc2nc(N)nc(N)c12 CHEMBL148577 IC50 3.6 nM
Cc1ccc(NCc2cnc3nc(N)nc(N)c3c2C)cc1Br CHEMBL148814 IC50 3.7 nM
CC(C)(C)c1ccc(OCCCON2C(N)=NC(N)=NC23CCOCC3)cc1 CHEMBL3974488 IC50 3.72 nM
Nc1nc(N)c2c(Cl)c(CNc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)ccc2n1 CHEMBL37061 I50 3.8 nM
Cc1c(CNc2ccc3ccc4cccc5ccc2c3c45)cnc2nc(N)nc(N)c12 CHEMBL359144 IC50 3.8 nM
CN(Cc1ccc2nc(N)nc(N)c2c1)c1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1 CHEMBL304397 I50 3.9 nM
CC1(C)N=C(N)N=C(N)N1OCCCOc1cccc(C(=O)CCc2ccccc2)c1 CHEMBL4099755 IC50 3.9 nM
Cc1c(CNc2cccc3cnccc23)cnc2nc(N)nc(N)c12 CHEMBL346666 IC50 4.0 nM
CC1c2ccc3c4ccccc4n(C)c3c2CCN1Cc1cnc(N)nc1N CHEMBL308758 IC50 4.0 nM
Nc1ncc(CN2CCc3c([nH]c4ccccc34)C2)c(N)n1 CHEMBL75944 IC50 4.0 nM
CC1(C)N=C(N)N=C(N)N1OCCCCOc1ccc(/C=C/C(=O)c2ccccc2)cc1 CHEMBL4060570 IC50 4.0 nM
NC1=NC2(CCSCC2)N(OCCCOc2ccc(Cl)cc2Cl)C(N)=N1 CHEMBL3943671 IC50 4.08 nM
Nc1nc(N)c2nc(CCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cnc2n1 CHEMBL293263 IC50 4.1 nM
Cc1c(NCc2ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc2)ccc2nc(N)nc(N)c12 CHEMBL36866 I50 4.1 nM
Cc1c(CNc2cc(C(F)(F)F)ccc2F)cnc2nc(N)nc(N)c12 CHEMBL358884 IC50 4.1 nM
COc1ccc(OC)c(CCc2cccc3nc(N)nc(N)c23)c1 CHEMBL349149 Ki 4.2 nM
CC1(C)N=C(N)N=C(N)N1OCCCCOc1cccc(C(=O)/C=C/c2ccccc2)c1 CHEMBL4082453 IC50 4.2 nM
COc1cc(CCc2cccc3nc(N)nc(N)c23)cc(OC)c1OC CHEMBL441298 Ki 4.3 nM
Cc1c(CNc2cccc3ccccc23)cnc2nc(N)nc(N)c12 CHEMBL23867 IC50 4.3 nM
Cc1c(CNc2cccc3ncccc23)cnc2nc(N)nc(N)c12 CHEMBL151958 IC50 4.3 nM
CCC(CC)n1ccc2c3c(N)nc(N)nc3ccc21 CHEMBL318721 Ki 4.5 nM
CCOc1ccc2ccccc2c1-c1cc2nc(N)nc(N)c2cc1C CHEMBL1818128 Ki 4.5 nM
CN(Cc1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1)c1ccc2nc(N)nc(N)c2c1 CHEMBL305253 I50 4.6 nM
Cc1c(CNc2cc(Br)ccc2Br)cnc2nc(N)nc(N)c12 CHEMBL147131 IC50 4.6 nM
COc1cc(N(C)c2cnc3nc(N)nc(N)c3c2)cc(OC)c1OC CHEMBL2382330 IC50 4.6 nM
COc1cc(NCc2cnc3nc(N)nc(N)c3c2C)cc(OC)c1OC CHEMBL23532 IC50 4.7 nM
COc1ccc(OC)c(N(C)c2cnc3nc(N)nc(N)c3c2)c1 CHEMBL2382329 IC50 4.7 nM
CC1(C)N=C(N)N=C(N)N1OCCCCOc1cccc(/C=C/C(=O)c2ccccc2)c1 CHEMBL4101407 IC50 4.8 nM
Cc1c(CNc2ccc(Cl)c(Cl)c2)cnc2nc(N)nc(N)c12 CHEMBL81820 IC50 5.0 nM
COc1ccc(NCc2cnc3nc(N)nc(N)c3c2C)cc1OC CHEMBL283518 IC50 5.1 nM
Cc1c(Cl)cccc1NCc1cnc2nc(N)nc(N)c2c1C CHEMBL147124 IC50 5.2 nM
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NC(C(=O)O)C(O)CC(=O)O)cc1 CHEMBL307820 IC50 5.3 nM
C#CCN(Cc1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1)c1ccc2nc(N)nc(N)c2c1 CHEMBL141648 I50 5.3 nM
CC1(C)N=C(N)N=C(N)N1OCCCOc1ccccc1 CHEMBL4080801 IC50 5.3 nM
C=CCN(Cc1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1)c1ccc2nc(N)nc(N)c2c1 CHEMBL141576 I50 5.4 nM
COc1cc(NCc2cnc3nc(N)nc(N)c3c2C)cc(C(F)(F)F)c1 CHEMBL23963 IC50 5.5 nM
CN(c1cnc2nc(N)nc(N)c2c1)c1cccc2ccccc12 CHEMBL2382334 IC50 5.6 nM
Nc1nc(N)c2cc(N(C=O)Cc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)ccc2n1 CHEMBL69713 I50 5.7 nM
C=C(CC(NC(=O)c1ccc(C(CC)Cc2cnc3nc(N)nc(N)c3n2)cc1)C(=O)O)C(=O)O CHEMBL308279 IC50 5.8 nM
Nc1nc(N)c2cc(CN(C=O)c3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)ccc2n1 CHEMBL303654 I50 5.8 nM
CCOc1ccc(-c2cccc(NS(C)(=O)=O)c2)cc1-c1ccc2c(N)nc(N)nc2c1 CHEMBL1818127 Ki 5.8 nM
O=C1Nc2ccccc2/C1=C/c1cn(CC(O)Cn2cc(/C=C3\C(=O)Nc4ccccc43)c3ccccc32)c2ccccc12 CHEMBL3787137 Ki 5.83 nM
Nc1nc(N)c2nc(CCc3ccc(C(=O)NC(C(=O)O)C(O)CC(=O)O)cc3)cnc2n1 CHEMBL73267 IC50 5.9 nM
Cc1cc(Br)ccc1NCc1cnc2nc(N)nc(N)c2c1C CHEMBL148877 IC50 5.9 nM
COc1cc(Cn2ccc3c4c(N)nc(N)nc4ccc32)cc(OC)c1OC CHEMBL353621 Ki 6.0 nM
COc1ccc2c(c1)CN(Cc1cnc(N)nc1N)CC2c1cccc([N+](=O)[O-])c1 CHEMBL78104 IC50 6.0 nM
Cc1ccc(Cl)cc1NCc1cnc2nc(N)nc(N)c2c1C CHEMBL147256 IC50 6.1 nM
Cc1cc(NCc2cnc3nc(N)nc(N)c3c2C)ccc1Br CHEMBL150382 IC50 6.1 nM
NC1=NC2(CCCC2)N(OCCCOc2cccc(C(=O)/C=C/c3ccccc3)c2)C(N)=N1 CHEMBL4070144 IC50 6.1 nM
Cc1c(CNc2ccc3c4c(cccc24)-c2ccccc2-3)cnc2nc(N)nc(N)c12 CHEMBL151451 IC50 6.2 nM
C=C(CC(NC(=O)c1ccc(N(C)Cc2cnc3nc(N)nc(N)c3n2)cc1)C(=O)O)C(=O)O CHEMBL65616 IC50 6.4 nM
CCCOc1ccc(Cc2cnc(N)nc2N)cc1 CHEMBL326989 Ki 6.4 nM
Cc1cc2c3c(N)nc(N)nc3ccc2n1C(C)C CHEMBL173617 Ki 6.4 nM
CC1(C)N=C(N)N=C(N)N1OCCCOc1ccc(/C=C/C(=O)c2ccccc2)cc1 CHEMBL4079985 IC50 6.4 nM
NC1=NC2(CCSCC2)N(OCCCOc2ccc(Br)cc2)C(N)=N1 CHEMBL3952384 IC50 6.46 nM
Cc1ccc(NCc2cnc3nc(N)nc(N)c3c2C)cc1Cl CHEMBL347974 IC50 6.7 nM
Cc1c(CNc2ccc3c(c2)Cc2ccccc2-3)cnc2nc(N)nc(N)c12 CHEMBL150082 IC50 6.7 nM
N#Cc1ccc(Cn2ccc3c4c(N)nc(N)nc4ccc32)cc1 CHEMBL526243 IC50 6.8 nM
COc1cc2c(cc1OC)C(c1ccc(Cl)cc1Cl)CN(Cc1cnc(N)nc1N)C2 CHEMBL305656 IC50 7.0 nM
Nc1nc2[nH]cc(CCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)c2c(=O)[nH]1 CHEMBL225072 Ki 7.0 nM
CCCCCOc1cccc(Cc2cnc(N)nc2N)c1 CHEMBL137305 Ki 7.1 nM
Cc1c(CNc2ccc3ncccc3c2)cnc2nc(N)nc(N)c12 CHEMBL147469 IC50 7.1 nM
NC1=NC2(CCOCC2)N(OCCCOc2ccc(Cl)cc2Cl)C(N)=N1 CHEMBL3931887 IC50 7.46 nM
Cc1cc2nc(-c3nccs3)n(-c3cc4nc(N)nc(N)c4cc3Cl)c2cc1C CHEMBL3128014 Ki 7.6 nM
Cc1c(Cc2ccccc2Br)cnc2nc(N)nc(N)c12 CHEMBL526013 IC50 7.6 nM
CC1(C)N=C(N)N=C(N)N1OCCCOc1cc(Cl)c(Cl)cc1Cl CHEMBL129788 Ki 7.7 nM
Cc1c(CNc2cc(Cl)ccc2Cl)cnc2nc(N)nc(N)c12 CHEMBL147257 IC50 8.0 nM
CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1 CHEMBL36 Ki 8.0 nM
COc1cc(Cc2cnc(N)nc2N)c2c(c1OC)OC(C1CC1)C=C2 CHEMBL134561 IC50 8.0 nM
NC1=NC2(CCOCC2)N(OCCCOc2ccc(Cl)c(Cl)c2)C(N)=N1 CHEMBL3965885 IC50 8.23 nM
CCOc1cccc(Cc2cnc(N)nc2N)c1 CHEMBL137448 Ki 8.6 nM
Nc1nc(N)c2cc(NCc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)ccc2n1 CHEMBL423123 I50 8.6 nM
COc1cc(OC)cc(N(C)Cc2cnc3nc(N)nc(N)c3c2C)c1 CHEMBL22623 IC50 8.7 nM
Nc1nc(N)c(-c2cccc(Cl)c2)c(CCCOc2ccccc2)n1 CHEMBL4565928 Ki 8.72 nM
CC(C)Oc1cccc(Cc2cnc(N)nc2N)c1 CHEMBL334919 Ki 8.8 nM
C=C(CC(NC(=O)c1ccc(CCc2cnc3nc(N)nc(N)c3n2)cc1)C(=O)O)C(=O)O CHEMBL307486 IC50 8.8 nM
CCOC(=O)C1=C(C)N=C(SCCC(=O)O)NC1c1ccccc1OC CHEMBL2261434 IC50 8.9 nM
Cc1nc(N)nc(N)c1NC(=O)C12CC3CC(CC(C3)C1)C2 CHEMBL1161155 Ki 9.0 nM
CC1(C)N=C(N)N=C(N)N1OCCCOc1cccc(C(=O)/C=C/c2ccccc2)c1 CHEMBL4098009 IC50 9.0 nM
Cc1nc(=O)c2cc(CN(C)c3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)ccc2[nH]1 CHEMBL225071 IC50 9.0 nM
CC1(C)N=C(N)N=C(N)N1OCCCOc1ccc(C(=O)/C=C/c2ccccc2)cc1 CHEMBL4069255 IC50 9.2 nM
Nc1nc2[nH]c(CCNC(=O)c3cccc(C(=O)NCc4ccccn4)c3)cc2c(=O)[nH]1 CHEMBL4587332 IC50 9.28 nM
COc1cccc(Cc2cnc(N)nc2N)c1 CHEMBL18967 Ki 9.6 nM
CCOC(=O)CCCOc1cc(NCc2ccc3nc(N)nc(N)c3c2)ccc1OC CHEMBL1165388 Ki 9.6 nM
CCCCCCOc1cccc(Cc2cnc(N)nc2N)c1 CHEMBL31547 Ki 9.8 nM
CCOc1ccc(Cc2cnc(N)nc2N)cc1 CHEMBL343271 Ki 9.8 nM
C[C@](CCC(=O)O)(NC(=O)c1ccc(CCC2CNc3nc(N)nc(N)c3C2)o1)C(=O)O CHEMBL167304 Ki 9.87 nM
CCc1cc2c3c(N)nc(N)nc3ccc2n1CC CHEMBL170144 Ki 10.0 nM
CC(C)c1cc2c(ccc3nc(N)nc(N)c32)[nH]1 CHEMBL353161 Ki 10.0 nM
Cc1c(CNc2ccc3ccccc3c2)cnc2nc(N)nc(N)c12 CHEMBL151367 IC50 10.0 nM
COc1cc(Cl)c(C)cc1NCc1cnc2nc(N)nc(N)c2c1C CHEMBL345258 IC50 10.0 nM
COc1cc2c(cc1OC)CN(Cc1cnc(N)nc1N)CC2 CHEMBL77582 IC50 10.0 nM
CCOC(=O)C1=C(C)NC(S/C(=C\c2ccc(OC)cc2)C(=O)OCC)=NC1c1ccccc1 CHEMBL2261696 IC50 10.0 nM
O=C(OC[C@@H]1CO1)c1cccc2c(=O)c3ccccc3[nH]c12 CHEMBL4453575 IC50 10.0 nM
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OCCNc1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1 CHEMBL4748139 IC50 10.0 nM
CCOc1ccc(-c2cccnc2)cc1-c1ccc2c(N)nc(N)nc2c1 CHEMBL1818126 Ki 10.1 nM
Nc1nc(N)c2nc(CNc3c(Cl)cc(C(=O)NC(CCCNC(=O)c4ccccc4C(=O)O)C(=O)O)cc3Cl)cnc2n1 CHEMBL309160 IC50 10.2 nM
COc1ccc(OC)c(CNc2ccc3nc(N)nc(N)c3c2Cl)c1 CHEMBL138060 Ki 10.2 nM
CCc1nc(N)nc(N)c1-c1ccccc1 CHEMBL22148 Ki 10.4 nM
CCCOc1cccc(Cc2cnc(N)nc2N)c1 CHEMBL343127 Ki 10.5 nM
Nc1ncc(Cc2cccc(OCc3ccccc3)c2)c(N)n1 CHEMBL274031 Ki 11.0 nM
COc1cc(CN(C)c2ccc3nc(N)nc(N)c3c2)cc(OC)c1 CHEMBL113816 IC50 11.0 nM
Nc1nc(O)c2cc(CN(C=O)c3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)ccc2n1 CHEMBL140448 I50 11.0 nM
CC(C)c1ccc(N(C)c2cnc3nc(N)nc(N)c3c2)cc1 CHEMBL2382332 Ki 11.0 nM
COc1ccc(OCCCON2C(N)=NC(N)=NC23CCOCC3)cc1 CHEMBL3912587 IC50 11.07 nM
CCOc1ccc(Br)cc1-c1cc2nc(N)nc(N)c2cc1C CHEMBL1818124 Ki 11.1 nM
CCOc1ccc(Cl)cc1-c1cc2nc(N)nc(N)c2cc1C CHEMBL1818122 Ki 11.1 nM
Nc1nc(N)c2nc(CNc3ccc(C(=O)NC(CCCCNC(=O)c4ccccc4C(=O)O)C(=O)O)cc3)cnc2n1 CHEMBL44919 IC50 11.4 nM
Nc1nc(N)c2nc(CNc3ccc(C(=O)NC(CCNC(=O)c4ccccc4C(=O)O)C(=O)O)cc3)cnc2n1 CHEMBL42819 IC50 11.6 nM
COc1ccc(NCc2ccc3nc(N)nc(N)c3c2)cc1OC CHEMBL1163286 Ki 11.8 nM
Cc1c(CNc2cnc3ccccc3c2)cnc2nc(N)nc(N)c12 CHEMBL149101 IC50 12.0 nM
COc1cc2c(c3c1OCO3)C(C)N(Cc1cnc(N)nc1N)CC2 CHEMBL77608 IC50 12.0 nM
CCOc1ccc(C=O)cc1-c1cc2nc(N)nc(N)c2cc1C CHEMBL1818121 Ki 12.0 nM
COc1ccc(N(C)c2cnc3nc(N)nc(N)c3c2)cc1 CHEMBL2382327 IC50 12.0 nM
COc1ccc(-c2cc3nc(N)nc(N)c3cc2C)cc1OC CHEMBL1818114 Ki 12.2 nM
Nc1nc(N)c(-c2ccccc2)c(CCCOc2ccccc2)n1 CHEMBL4553483 Ki 12.5 nM
Nc1nc(N)c(-c2cccc(Cl)c2)c(CCCCOc2ccccc2)n1 CHEMBL4558959 Ki 12.77 nM
Nc1ncc(Cc2cccc(OC3CCCCO3)c2)c(N)n1 CHEMBL344592 Ki 13.0 nM
COC(=O)CCCCOc1cc(NCc2ccc3nc(N)nc(N)c3c2)ccc1OC CHEMBL1165305 Ki 13.0 nM
NC1=NC2(CCCC2)N(OCCOc2cccc(C(=O)/C=C/c3ccccc3)c2)C(N)=N1 CHEMBL4083419 IC50 13.1 nM
Nc1nc(N)c(-c2cccc(Cl)c2)c(CCCCOc2cccc(OCC(=O)O)c2)n1 CHEMBL4447272 Ki 13.41 nM
Nc1nc(N)c(-c2cccc(Cl)c2)c(CCCOc2cccc(OCC(=O)O)c2)n1 CHEMBL4590684 Ki 13.59 nM
Nc1cc(N)c2cc(CCc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)ccc2c1 CHEMBL109260 I50 14.0 nM
CCCc1cc(Cc2cnc(N)nc2N)cc2c1OC(C)C2C CHEMBL61857 I50 14.0 nM
COc1ccc(NCc2cnc3nc(N)nc(N)c3c2C)cc1F CHEMBL356620 IC50 14.0 nM
COc1ccccc1N(C)c1cnc2nc(N)nc(N)c2c1 CHEMBL2382328 IC50 14.0 nM
CCOC(=O)CCCN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NC(CCC(=O)OCC)C(=O)OCC)cc1 CHEMBL285474 Ki 14.1 nM
CC1(C)N=C(N)N=C(N)N1OCCOc1ccc(C(=O)/C=C/c2ccccc2)cc1 CHEMBL4074887 IC50 14.1 nM
Nc1nc(N)c(-c2cccc(Cl)c2)c(CCc2ccccc2OCc2ccccc2)n1 CHEMBL4459902 Ki 14.36 nM
COc1cc(NCc2cnc3nc(N)nc(N)c3c2C)cc(OC)c1 CHEMBL23569 IC50 15.0 nM
CCCOc1ccc(NCc2cnc3nc(N)nc(N)c3c2C)cc1OC CHEMBL151947 IC50 15.0 nM
NCCCC(NC(=O)c1ccc(NCc2ccc3nc(N)nc(N)c3n2)cc1)C(=O)O CHEMBL35921 IC50 16.0 nM
O=C(Nc1c(F)c(F)c(-c2ccccc2)c(F)c1F)c1nsnc1O CHEMBL4105330 IC50 16.0 nM
CCc1nc(N)nc(N)c1Cc1cccc(-c2ccc(C(=O)OC)cc2)c1 CHEMBL5421199 Ki 16.58 nM
Cc1c(CNc2cccc(Cl)c2)cnc2nc(N)nc(N)c12 CHEMBL80066 IC50 17.0 nM
CCc1nc(N)nc(N)c1OCCCOc1ccccc1CCC(=O)O CHEMBL3040038 Ki 17.41 nM
CCOc1ccc(NCc2cnc3nc(N)nc(N)c3c2C)cc1OC CHEMBL358195 IC50 18.0 nM
Nc1nc(N)c2nc(CNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)ccc2n1 CHEMBL2153707 IC50 18.0 nM
Cn1nnc(O)c1C(=O)Nc1c(F)c(F)c(-c2ccccc2)c(F)c1F CHEMBL4098306 IC50 18.0 nM
CCc1nc(N)nc(N)c1OCCCOc1ccc(-c2c(N)nc(N)nc2CC)cc1 CHEMBL4462726 Ki 18.1 nM
Nc1nc(N)c(-c2ccccc2)c(CCCOc2cccc(OCC(=O)O)c2)n1 CHEMBL4452609 Ki 18.24 nM
NC1=NC2(CCSCC2)N(OCCCOc2ccc(Cl)cc2)C(N)=N1 CHEMBL3946546 IC50 18.28 nM
Nc1nc(N)c(-c2cccc(Cl)c2)c(CCCCCOc2ccccc2)n1 CHEMBL4437388 Ki 18.41 nM
CCCCCCCOc1cccc(Cc2c(N)nc(N)nc2CC)c1 CHEMBL135935 Ki 19.0 nM
Cc1ccc(F)cc1NCc1cnc2nc(N)nc(N)c2c1C CHEMBL347061 IC50 19.0 nM
Nc1nc(N)c2nc(CNc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3F)cnc2n1 CHEMBL18925 I50 19.0 nM
CCc1sc2nc(N)[nH]c(=O)c2c1Sc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 CHEMBL551049 IC50 19.0 nM
CCc1nc(N)nc(N)c1Cc1cccc(-c2cccc(C(=O)OC)c2)c1 CHEMBL5415214 Ki 19.4 nM
Nc1nc(N)c(-c2cccc(Cl)c2)c(CCCOc2cccc(OCCCC(=O)O)c2)n1 CHEMBL4461699 Ki 19.55 nM
NC1=NC2(CCCC2)N(OCCCOc2ccccc2)C(N)=N1 CHEMBL1800937 IC50 19.9 nM
C=CCc1cc(Cc2cnc(N)nc2N)cc(CCC)c1O CHEMBL24503 I50 20.0 nM
Cc1c(CNc2ccc(OC(F)F)cc2)cnc2nc(N)nc(N)c12 CHEMBL345708 IC50 20.0 nM
Cc1sc2nc(N)[nH]c(=O)c2c1Sc1ccc(C(=O)N(CCC(=O)O)C(=O)O)cc1 CHEMBL522363 IC50 20.0 nM
O=c1c2ccccc2n(CC2CO2)c2ccccc12 CHEMBL4458303 IC50 20.0 nM
CCc1nc(N)nc(N)c1OCCCOc1ccc(-c2c(N)nc(N)nc2CC)cc1 CHEMBL4454693 Ki 20.2 nM
Cc1cc2c(N)nc(N)nc2cc1-c1ccccc1C(C)C CHEMBL1818106 Ki 20.9 nM
COc1cc2c(c3c1OCO3)[C@H](C)N(Cc1cnc(N)nc1N)CC2 CHEMBL420755 IC50 21.0 nM
Nc1nc(N)c(-c2cccc(Cl)c2)c(CCCCOc2cccc(OCCCC(=O)O)c2)n1 CHEMBL4462327 Ki 21.72 nM
CCc1nc(N)nc(N)c1Cc1cccc(-c2ccc(C(=O)O)cc2)c1 CHEMBL5432011 Ki 22.0 nM
Nc1nc(N)c(-c2ccccc2)c(CCc2ccccc2OCc2ccccc2)n1 CHEMBL4515405 Ki 22.07 nM
CCOc1ccc(C)cc1-c1cc2nc(N)nc(N)c2cc1C CHEMBL1818123 Ki 22.2 nM
CC1(C)N=C(N)N=C(N)N1c1ccc(CCCCc2ccc(S(=O)(=O)F)cc2Cl)c(Cl)c1 CHEMBL33697 Log 1/Ki 22.39 nM
CCc1nc(N)nc(N)c1OCCCOc1cccc(-c2c(N)nc(N)nc2CC)c1 CHEMBL4442735 Ki 22.5 nM
CCOC(=O)CCCOc1ccccc1CCc1nc(N)nc(N)c1-c1cccc(Cl)c1 CHEMBL4444614 Ki 23.42 nM
CCCCCCCCOc1cccc(Cc2cnc(N)nc2N)c1 CHEMBL31235 Ki 24.0 nM
CCCc1cc2c3c(N)nc(N)nc3ccc2n1CC CHEMBL353763 Ki 24.0 nM
Nc1nc(N)c2cc(CNc3cc(Cl)ccc3Cl)cnc2n1 CHEMBL145979 Ki 24.4 nM
COC(=O)c1ccc(COc2cc(NCc3ccc4nc(N)nc(N)c4c3)ccc2OC)cc1 CHEMBL1165306 Ki 24.5 nM
C[C@H](Oc1cccc2nc(N)nc(N)c12)c1cccc(Cl)c1 CHEMBL253976 IC50 25.0 nM
COc1ccc(OC)c(CN(C)c2ccc3nc(N)nc(N)c3c2)c1 CHEMBL325434 IC50 26.0 nM
COc1ccc(OC)c(CN(C)c2cnc3nc(N)nc(N)c3c2)c1 CHEMBL32113 IC50 26.0 nM
CC(=O)c1cccc(-c2cc3nc(N)nc(N)c3cc2C)c1 CHEMBL1818120 Ki 26.3 nM
CN(Cc1cccc2c1CCCC2)c1ccc2nc(N)nc(N)c2c1 CHEMBL114354 IC50 27.0 nM
Cc1c(CNc2ccc(Cl)cc2)cnc2nc(N)nc(N)c12 CHEMBL23416 IC50 27.0 nM
Nc1nc(N)c2nc(CNc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)c(F)c3)cnc2n1 CHEMBL19227 I50 27.0 nM
Nc1nc(N)c(-c2ccccc2)c(CCc2ccccc2OCCCc2ccccc2)n1 CHEMBL4557136 Ki 27.27 nM
COc1ccc(OC)c(-c2cc3nc(N)nc(N)c3cc2C)c1 CHEMBL1818115 Ki 27.5 nM
COc1ccc(CO)cc1-c1cc2nc(N)nc(N)c2cc1C CHEMBL3681399 Ki 27.5 nM
CC(C)c1cc(Cc2cnc(N)nc2N)cc(C(C)C)c1O CHEMBL440946 I50 29.0 nM
CCc1cc2c3c(N)nc(N)nc3ccc2n1C CHEMBL170900 Ki 29.0 nM
Nc1nc(N)c(-c2ccccc2)c(CCCOc2cccc(OCCCC(=O)O)c2)n1 CHEMBL4586252 Ki 29.05 nM
Nc1nc2[nH]c(CCNC(=O)c3ccc(C(=O)NCc4ccccn4)cc3)cc2c(=O)[nH]1 CHEMBL4444154 IC50 29.29 nM
CC(C)COc1ccc2nc(N)nc(N)c2c1Sc1ccc(C(C)(C)C)cc1 CHEMBL121669 I50 30.0 nM
CCCCc1cc2c3c(N)nc(N)nc3ccc2n1C(C)(C)C CHEMBL171629 Ki 30.0 nM
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NC(CCC(=O)Nc2cccc(B(O)O)c2)C(=O)O)cc1 CHEMBL157117 IC50 30.0 nM
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OCCNc1ccc(C(=O)NC(Cc2cc3ccccc3[nH]2)C(=O)O)cc1 CHEMBL4757974 IC50 30.0 nM
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1 CHEMBL426 IC50 30.0 nM
Nc1nc(N)c2nc(CNc3ccc(C(=O)NC(CCC(=O)Nc4cccc(C(=O)O)c4)C(=O)O)cc3)cnc2n1 CHEMBL421973 IC50 32.0 nM
CN(CC1CCc2nc(N)nc(N)c2N1C=O)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 CHEMBL2153711 IC50 32.0 nM
Cc1ccc(N(C)c2cnc3nc(N)nc(N)c3c2)cc1 CHEMBL2382331 IC50 32.0 nM
CCOC(=O)CCCOc1ccccc1CCc1nc(N)nc(N)c1-c1ccccc1 CHEMBL4542001 Ki 32.43 nM
NC1=NC2(CCOCC2)N(OCCCOc2ccc(Br)cc2)C(N)=N1 CHEMBL3893628 IC50 32.49 nM
Nc1nc(N)c(-c2ccccc2)c(CCCCCOc2ccccc2)n1 CHEMBL4467953 Ki 32.89 nM
COc1ccc(OC)c(NCc2cccc3nc(N)nc(N)c23)c1 CHEMBL350730 Ki 33.0 nM
Cc1cc(NCc2cnc3nc(N)nc(N)c3c2C)c(Cl)cc1F CHEMBL146968 IC50 33.0 nM
CN(CC1CCc2nc(N)nc(N)c2N1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 CHEMBL2153709 IC50 33.0 nM
CC(=O)N(CC1CCc2nc(N)nc(N)c2N1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 CHEMBL2151066 IC50 33.0 nM
NC1=NC2(CCOCC2)N(OCCCOc2ccc(Cl)cc2)C(N)=N1 CHEMBL3903562 IC50 33.56 nM
CCc1nc(N)nc(N)c1-c1ccc(OCCCOc2ccc(-c3c(N)nc(N)nc3CC)cc2)cc1 CHEMBL4460601 Ki 33.6 nM
Nc1nc(O)c2cc(CNc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)ccc2n1 CHEMBL23977 I50 34.0 nM
CC(Oc1cccc2nc(N)nc(N)c12)c1cccc(Cl)c1 CHEMBL398416 IC50 34.0 nM
CCOc1ccc(C(=O)N(CC)CC)cc1-c1cc2nc(N)nc(N)c2cc1C CHEMBL1818129 Ki 34.0 nM
Nc1nc(N)c(-c2ccccc2)c(CCCCOc2cccc(OCCCC(=O)O)c2)n1 CHEMBL4546946 Ki 34.84 nM
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NC(CCC(=O)Nc2cccc(C(=O)O)c2)C(=O)O)cc1 CHEMBL155023 IC50 35.0 nM
NCCCC(NC(=O)c1ccc(NCc2ccc3nc(N)nc(N)c3c2)cc1)C(=O)O CHEMBL32439 IC50 35.0 nM
CC1(C)N=C(N)N=C(N)N1OCCOc1cccc(C(=O)/C=C/c2ccccc2)c1 CHEMBL4104895 IC50 35.6 nM
CCCCCCCCCOc1cccc(Cc2cnc(N)nc2N)c1 CHEMBL137641 Ki 36.0 nM
COc1ccc(C(F)(F)F)cc1N(C)Cc1cnc2nc(N)nc(N)c2c1C CHEMBL23076 IC50 36.0 nM
O=C(Nc1c(F)c(F)c(-c2ccccc2)c(F)c1F)c1c(O)nnn1CC1CC1 CHEMBL4090575 IC50 36.0 nM
NC1=NC2(CCOCC2)N(OCCCOc2cc(Cl)c(Cl)cc2Cl)C(N)=N1 CHEMBL3894617 IC50 36.01 nM
Nc1nc2[nH]c(CCNC(=O)c3ccc(C(=O)NCc4cccnc4)cc3)cc2c(=O)[nH]1 CHEMBL4435374 IC50 37.94 nM
Nc1nc(N)c2c(COc3ccccc3F)cccc2n1 CHEMBL251906 IC50 39.0 nM
CC(Cc1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1)c1cnc2nc(N)nc(N)c2n1 CHEMBL431359 IC50 40.0 nM
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OCCNc1ccc(C(=O)NC(C(=O)O)C(C)C)cc1 CHEMBL4759800 IC50 40.0 nM
Cc1c(C(=O)Nc2c(F)c(F)c(-c3ccccc3)c(F)c2F)c(O)nn1C CHEMBL4088968 IC50 41.0 nM
CCc1ccccc1-c1cc2nc(N)nc(N)c2cc1C CHEMBL1818117 Ki 41.1 nM
CC1(C)N=C(N)N=C(N)N1c1cccc(SCc2ccccc2)c1 CHEMBL20975 Log 1/Ki 42.66 nM
CCCc1cc(Cc2cnc(N)nc2N)cc(CC)c1OC CHEMBL279455 I50 44.0 nM
Cc1ccc(Cl)c(NCc2cnc3nc(N)nc(N)c3c2C)c1 CHEMBL149273 IC50 44.0 nM
COc1cc2c(cc1OC)C(C)N(Cc1cnc(N)nc1N)CC2 CHEMBL74781 IC50 44.0 nM
[C-]#[N+]c1cc(N)cc(-c2cc3nc(N)nc(N)c3cc2C)c1 CHEMBL3681403 Ki 44.0 nM
[C-]#[N+]Cc1cccc(-c2cc3nc(N)nc(N)c3cc2C)c1 CHEMBL3681404 Ki 44.0 nM
O=C(Nc1c(F)c(F)c(-c2cccc(OC(F)(F)F)c2)c(F)c1F)c1nsnc1O CHEMBL4081077 IC50 44.0 nM
Cc1cc2c(N)nc(N)nc2cc1-c1ccc(S(C)(=O)=O)cc1 CHEMBL1818112 Ki 44.1 nM
CCc1nc(N)nc(N)c1C#CC(C)c1cc(OC)cc(-c2cccc3cnccc23)c1 CHEMBL2335421 IC50 45.0 nM
Cn1nc(O)c(C(=O)Nc2c(F)c(F)c(-c3ccccc3)c(F)c2F)n1 CHEMBL4062046 IC50 45.0 nM
Nc1nc(N)c(-c2ccccc2)c(CCCCOc2cccc(OCC(=O)O)c2)n1 CHEMBL4588852 Ki 45.97 nM
CCCc1cc(Cc2cnc(N)nc2N)cc2c1OC(C)(C)C2 CHEMBL301629 I50 46.0 nM
CN(c1cnc2nc(N)nc(N)c2c1)c1cc(F)ccc1F CHEMBL2382335 IC50 46.0 nM
CCOC(=O)CCCCN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NC(CCC(=O)OCC)C(=O)OCC)cc1 CHEMBL35552 Ki 46.2 nM
NC1=NC2(CCOCC2)N(OCCCOc2ccc(F)cc2)C(N)=N1 CHEMBL3957080 IC50 46.62 nM
COc1cc(-c2cc3nc(N)nc(N)c3cc2C)cc(OC)c1OC CHEMBL3681413 Ki 47.1 nM
Cc1nc(N)nc(N)c1OCCCOc1cc(Cl)c(Cl)cc1Cl CHEMBL3819601 Ki 47.6 nM
Nc1nc(N)c(-c2ccccc2)c(CCCCOc2ccccc2)n1 CHEMBL4526752 Ki 48.67 nM
Nc1nc2[nH]c(CCNC(=O)c3ccc(C(=O)NCc4ccncc4)cc3)cc2c(=O)[nH]1 CHEMBL4552684 IC50 48.95 nM
CCCc1cc(Cc2cnc(N)nc2N)cc(CC)c1O CHEMBL25888 I50 49.0 nM
COc1cc(N(C)Cc2cccc3nc(N)nc(N)c23)cc(OC)c1OC CHEMBL162270 Ki 49.0 nM
CCc1nc(N)nc(N)c1C#CC(C)c1ccc(-c2ccc(C(=O)OC)cc2)cc1OC CHEMBL3234318 IC50 49.0 nM
NC1=NC2(CCCCC2)N(OCCCOc2ccc(Cl)cc2)C(N)=N1 CHEMBL1800948 IC50 49.04 nM
COc1ccc(NCc2ccc3nc(N)nc(N)c3c2)cc1OCCCC(=O)O CHEMBL1164279 Ki 49.8 nM
COc1ccc(CN(C)c2ccc3nc(N)nc(N)c3c2)c(OC)c1 CHEMBL115804 IC50 50.0 nM
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NC(CCCNCC(=O)O)C(=O)O)cc1 CHEMBL32691 IC50 50.0 nM
Cc1cc2c(N)nc(N)nc2cc1-c1c[nH]c2ccccc12 CHEMBL3686071 Ki 50.5 nM
CCCCCCCCCCOc1cccc(Cc2cnc(N)nc2N)c1 CHEMBL334695 Ki 52.0 nM
Nc1nc(N)c(-c2cccc(Cl)c2)c(COc2cccc(OCC(=O)O)c2)n1 CHEMBL4566524 Ki 52.39 nM
COc1cnc(Cl)cc1-c1cc2nc(N)nc(N)c2cc1C CHEMBL3686069 Ki 52.4 nM
COC(=O)c1ccc2c(c1)nc(-c1nccs1)n2-c1ccc2c(N)nc(N)nc2c1 CHEMBL3681412 Ki 53.1 nM
CC1(C)N=C(N)N=C(N)N1OCCOc1ccc(/C=C/C(=O)c2ccccc2)cc1 CHEMBL4080662 IC50 53.4 nM
Nc1nc2[nH]c(CCNC(=O)c3cccc(C(=O)NCc4cccnc4)c3)cc2c(=O)[nH]1 CHEMBL4531384 IC50 53.42 nM
Nc1nc(N)c2cc(Cn3ccnc3)c(-c3ccc(CO)c(CO)c3)cc2n1 CHEMBL3681401 Ki 53.6 nM
COc1nc(CO)ncc1-c1cc2nc(N)nc(N)c2cc1C CHEMBL3681411 Ki 54.7 nM
[C-]#[N+]c1cccc(-c2cc3nc(N)nc(N)c3cc2C)c1 CHEMBL3681402 Ki 55.0 nM
CC1(C)N=C(N)N=C(N)N1c1ccc(Cl)cc1 CHEMBL747 Ki 55.6 nM
CCOC(=O)CCCCCN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NC(CCC(=O)OCC)C(=O)OCC)cc1 CHEMBL265757 Ki 55.7 nM
Cc1cc2c(N)nc(N)nc2cc1-c1cc(CO)ncc1Cl CHEMBL3681410 Ki 56.0 nM
Cc1ccc(OCCCON2C(N)=NC(N)=NC23CCOCC3)cc1 CHEMBL3965991 IC50 56.75 nM
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NC(CC(C#N)C(=O)O)C(=O)O)cc1 CHEMBL65620 IC50 57.0 nM
Cc1ccc(C)c(NCc2cnc3nc(N)nc(N)c3c2C)c1 CHEMBL23383 IC50 57.0 nM
CCc1nc(N)nc(N)c1C#CCc1cc(OC)c(OC)c(OC)c1 CHEMBL485959 IC50 57.0 nM
CN(c1ccccc1)c1cnc2nc(N)nc(N)c2c1 CHEMBL2382326 IC50 57.0 nM
COc1c(C(C)(C)C)cc(Cc2cnc(N)nc2N)cc1C(C)(C)C CHEMBL24374 I50 58.0 nM
CCOc1cc(Cc2cnc(N)nc2N)cc(OCC)c1-n1cccc1 CHEMBL280378 Log 1/Ki 58.88 nM
CC1(C)N=C(N)N=C(N)N1OCCOc1cccc(/C=C/C(=O)c2ccccc2)c1 CHEMBL4097389 IC50 59.2 nM
COc1ccc(OC)c(C(C#Cc2c(C)nc(N)nc2N)OC)c1 CHEMBL584390 IC50 60.0 nM
CCc1nc(N)nc(N)c1C#CCc1cc(OC)cc(-c2cccc3cnccc23)c1 CHEMBL2335420 IC50 60.0 nM
Nc1nc(N)c2nc(CCCc3ccccc3)ccc2n1 CHEMBL4226361 IC50 60.0 nM
CC(C)(C)c1cc(Cc2cnc(N)nc2N)cc(C(C)(C)C)c1O CHEMBL277176 I50 61.0 nM
CCc1nc(N)nc(N)c1C#CCc1cc(OC)cc(-c2ccncc2)c1 CHEMBL3219804 IC50 61.0 nM
Nc1nc2[nH]c(CCNC(=O)c3cccc(C(=O)NCc4ccncc4)c3)cc2c(=O)[nH]1 CHEMBL4522253 IC50 65.88 nM
CCCc1cc(Cc2cnc(N)nc2N)cc2c1OC(C)C2 CHEMBL61356 I50 66.0 nM
CCc1c(Sc2ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc2)[nH]c2nc(N)nc(N)c12 CHEMBL438664 IC50 66.0 nM
CCCc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC CHEMBL278345 I50 67.0 nM
COc1cc(-c2ccccc2)ccc1NCc1cnc2nc(N)nc(N)c2c1C CHEMBL147504 IC50 68.0 nM
Cc1c(CNc2cc(F)ccc2F)cnc2nc(N)nc(N)c12 CHEMBL151109 IC50 69.0 nM
CC1(C)N=C(N)N=C(N)N1OCc1ccccc1 CHEMBL1824770 IC50 69.0 nM
CCC(Cc1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1)c1cnc2nc(N)nc(N)c2n1 CHEMBL302068 IC50 70.0 nM
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)NO)C(=O)O)cc1 CHEMBL244883 IC50 70.0 nM
CC1(C)N=C(N)N=C(N)N1c1cccc(Br)c1 CHEMBL268088 Ki 70.0 nM
NCCCC(NC(=O)c1ccc(NCc2cnc3nc(N)nc(N)c3n2)cc1)C(=O)O CHEMBL280864 IC50 72.0 nM
Nc1nc(N)c(-c2cccc(Cl)c2)c(COc2cccc(OCCCC(=O)O)c2)n1 CHEMBL4468791 Ki 74.16 nM
CCCCCCCOc1cccc(Cc2c(C)nc(N)nc2N)c1 CHEMBL138230 Ki 75.0 nM
CN(C)C(=O)c1cccc(COc2ccc(N3C(N)=NC(N)=NC3(C)C)cc2Cl)c1 CHEMBL6666 Log 1/Ki 77.62 nM
CN(Cc1ccc2nc(N)nc(O)c2c1)c1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1 CHEMBL343140 I50 83.0 nM
CCOc1ccccc1-c1ccc2c(N)nc(N)nc2c1 CHEMBL1818118 Ki 85.0 nM
NC1=NC2(CCOCC2)N(OCCCOc2ccccc2)C(N)=N1 CHEMBL3924555 IC50 86.11 nM
Cc1cc2c3c(N)nc(N)nc3ccc2n1C CHEMBL353929 Ki 87.0 nM
C=C(CC(NC(=O)c1ccc(NCc2cnc3nc(N)nc(N)c3n2)cc1)C(=O)O)C(=O)O CHEMBL65711 IC50 88.0 nM
CCc1nc(N)nc(N)c1C#CC(C)c1cc(OC)c(OC)c(OC)c1 CHEMBL575223 IC50 88.0 nM
Nc1nc2sc3cccc(CNc4ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc4)c3c2c(=O)[nH]1 CHEMBL1738741 IC50 90.0 nM
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OCCNc1ccc(C(=O)NC(Cc2ccccc2)C(=O)O)cc1 CHEMBL4783671 IC50 90.0 nM
Nc1nc(N)c2c(Sc3ccccc3Cl)cccc2n1 CHEMBL334307 I50 92.0 nM
Nc1ncc(N2CCN(c3ccc(Cl)c(Cl)c3)CC2)c(N)n1 CHEMBL3953069 IC50 92.0 nM
C/C=C/c1cc(Cc2cnc(N)nc2N)cc(OC)c1OC CHEMBL23338 I50 93.0 nM
Cc1cc2nc(-c3nccs3)n(-c3ccc4c(N)nc(N)nc4c3)c2cc1C CHEMBL3128021 Ki 93.0 nM
CC1(C)N=C(N)N=C(N)N1c1cccc(Cl)c1 CHEMBL7130 Log 1/Ki 93.33 nM
CC(=O)C1=C(C)N=C(SCCC(=O)O)NC1c1cccc(O)c1 CHEMBL2261433 IC50 94.0 nM
Cc1ccccc1-c1cc2nc(N)nc(N)c2cc1C CHEMBL1818116 Ki 95.6 nM
Nc1nc(N)c2c(C#Cc3ccccc3)cccc2n1 CHEMBL355151 Ki 96.3 nM
COc1ccc(-c2ccccc2)cc1C(C)C#Cc1c(C)nc(N)nc1N CHEMBL3234115 IC50 97.0 nM
Nc1nc(O)c2c(Cl)c(CNc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)ccc2n1 CHEMBL38561 I50 100.0 nM
Nc1nc(O)c2c(Cl)c(NCc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)ccc2n1 CHEMBL39851 I50 100.0 nM
COc1cc(Nc2nc3cc(N)cc(N)c3nc2-c2ccccc2)cc(OC)c1OC CHEMBL464504 Ki 100.0 nM
Nc1nc2sc3cccc(CNc4ccc5c(c4)CN([C@@H](CCC(=O)O)C(=O)O)C5=O)c3c2c(=O)[nH]1 CHEMBL1738740 IC50 100.0 nM
COc1ccc(/C=C2\CCCc3c2nc(C)nc3-c2ccc(OC)c(OC)c2)cc1OC CHEMBL3115730 IC50 100.0 nM
CCc1nc(N)nc(N)c1C#CC(C)c1cc(-c2ccccc2)ccc1OC CHEMBL3644520 IC50 100.0 nM
O=C1Nc2ccccc2/C1=C/c1cn(CC(O)Cn2c3ccccc3c(=O)c3ccccc32)c2ccccc12 CHEMBL4533705 IC50 100.0 nM
O=C(Nc1c(F)c(F)c(-c2ccccc2)c(F)c1F)c1nn(CC2CC2)nc1O CHEMBL4071260 IC50 108.0 nM
CCc1nc(N)nc(N)c1Cc1cccc(-c2cccc(C(=O)O)c2)c1 CHEMBL5397904 Ki 108.4 nM
C=CCc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC CHEMBL282022 I50 110.0 nM
CCc1cc(Cc2cnc(N)nc2N)cc2c1OC(C)C2 CHEMBL58481 I50 110.0 nM
Nc1nc(=O)c2cc(NCc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)ccc2[nH]1 CHEMBL36739 I50 110.0 nM
Cc1nc2cc(Nc3nc(Nc4ccc(F)cc4)nc(N4CCCC4)n3)ccc2n1Cc1ccccc1 CHEMBL3746911 IC50 110.0 nM
CC1(C)N=C(N)N=C(N)N1c1ccc(Cl)c(Cl)c1 CHEMBL92583 Ki 110.0 nM
CCc1cc(Cc2cnc(N)nc2N)cc(CC)c1O CHEMBL25817 I50 120.0 nM
Cc1c(CNc2ccccc2Cl)cnc2nc(N)nc(N)c12 CHEMBL81119 IC50 120.0 nM
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)N2CCC[C@H]2C(=O)NO)C(=O)O)cc1 CHEMBL388879 IC50 120.0 nM
Cc1cc2nc(N)[nH]c(=O)c2n1Cc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 CHEMBL252132 IC50 120.0 nM
Nc1nc(N)c2c(Sc3ccc(Cl)cc3)cccc2n1 CHEMBL310759 Kd 120.0 nM
Cc1ccc(-c2c(CN3CCOCC3)nc3scc(C(=O)NN)n23)cc1 CHEMBL5170804 IC50 123.0 nM
CC1=C(Sc2ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc2)C2C(=O)NC(N)=NC2N1 CHEMBL336487 IC50 124.0 nM
Nc1nc(N)c2cc(COC(=O)c3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)ccc2n1 CHEMBL117602 IC50 125.0 nM
CCc1nc(N)nc(N)c1C#CC(C)c1ccc(-c2ccncc2)cc1OC CHEMBL3234117 IC50 127.0 nM
Cc1cc2c(N)nc(N)nc2cc1-c1ccccc1 CHEMBL1818108 Ki 129.0 nM
CCc1nc(N)nc(N)c1C#CCc1cccc(OC)c1OC CHEMBL486570 IC50 130.0 nM
CC1(C)N=C(N)N=C(N)N1c1cccc(C(F)(F)F)c1 CHEMBL6948 Ki 130.0 nM
Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1 CHEMBL439 IC50 130.0 nM
CCCCCCCOc1cccc(Cc2cnc(N)nc2N)c1 CHEMBL285209 Ki 131.0 nM
NC1=NC2(CCC2)N(OCc2ccccc2)C(N)=N1 CHEMBL1824773 IC50 134.0 nM
CC1(C)N=C(N)N=C(N)N1c1cccc(COc2cccc3ccccc23)c1 CHEMBL20466 Log 1/Ki 134.9 nM
CCc1nc(N)nc(N)c1C#CC(C)c1ccc(-c2ccc(O)cc2)cc1OC CHEMBL3234118 IC50 136.0 nM
Cc1cc2c(N)nc(N)nc2cc1-c1ccc(N)cc1 CHEMBL1818110 Ki 138.0 nM
CCc1nc(N)nc(N)c1Cc1ccc(-c2cccc(C(=O)OC)c2)cc1 CHEMBL5406769 Ki 139.78 nM
COc1ccc(OC)c(C#Cc2cccc3nc(N)nc(N)c23)c1 CHEMBL162312 Ki 140.0 nM
CCOc1cc(Cc2cnc(N)nc2N)cc2c1OCO2 CHEMBL58908 I50 140.0 nM
COc1ccc(CN(C)c2ccc3nc(N)nc(N)c3c2)c(OC)c1OC CHEMBL117750 IC50 140.0 nM
COc1cc(Cc2cnc(N)nc2N)cc2c(N(C)C)cc(C)nc12 CHEMBL58366 I50 140.0 nM
CCc1nc(N)nc(N)c1C#CCc1cc(OC)cc(-c2ccc3c(c2)OCCO3)c1 CHEMBL2335422 IC50 140.0 nM
CCc1nc(N)nc(N)c1C#CCc1cc(OC)cc(-c2ccccc2)c1 CHEMBL1270633 IC50 140.0 nM
Cc1c(CNc2cccc3c2CCCC3)cnc2nc(N)nc(N)c12 CHEMBL282948 IC50 142.0 nM
CCc1nc(N)nc(N)c1C#CC(C)c1ccc(-c2ccc(N(C)C)cc2)cc1OC CHEMBL3234319 IC50 147.0 nM
CCc1nc(N)nc(N)c1Cc1ccc(-c2cccc(C(=O)O)c2)cc1 CHEMBL5417784 Ki 147.13 nM
CCc1nc(N)nc(N)c1C#CC(C)c1ccc(-c2ccc(F)cc2)cc1OC CHEMBL3234320 IC50 148.0 nM
COc1ccc(C)c(NCc2cnc3nc(N)nc(N)c3c2C)c1 CHEMBL23713 IC50 150.0 nM
CN(c1cc(F)c(F)c(F)c1)c1cnc2nc(N)nc(N)c2c1 CHEMBL2382336 IC50 150.0 nM
CCC1(C)N=C(N)N=C(N)N1OCc1ccccc1 CHEMBL1824771 IC50 155.0 nM
CCc1nc(N)nc(N)c1C#CCc1cc(OC)cc(-c2ccc(C(=O)O)cc2)c1 CHEMBL3828291 Ki 158.77 nM
CC(=O)Nc1nc(C(=O)NNC(=O)CCN2CCOCC2)cs1 CHEMBL5269071 IC50 159.0 nM
CCc1nc(N)nc(N)c1C#CCc1cccc(-c2cncnc2)c1 CHEMBL3644523 IC50 160.0 nM
CCOc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC CHEMBL23609 I50 170.0 nM
Nc1nc(O)c2cc(COc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)ccc2n1 CHEMBL139551 I50 170.0 nM
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)N[C@@H](Cc2ccccc2)C(=O)NO)C(=O)O)cc1 CHEMBL396296 IC50 170.0 nM
COc1cc2nc(-c3nccs3)n(-c3cc4nc(N)nc(N)c4cc3C)c2cc1OC CHEMBL3128017 Ki 170.0 nM
CCc1nc(N)nc(N)c1C#CC(C)c1ccc(-c2ccc(OC(N)=O)cc2)cc1OC CHEMBL3234317 IC50 170.0 nM
COc1cc2c(cc1CO)nc(-c1nccs1)n2-c1cc2nc(N)nc(N)c2cc1C CHEMBL3681408 Ki 170.0 nM
CCc1nc(N)nc(N)c1C#CC(C)c1ccc(-c2ccccc2)cc1OC CHEMBL3234116 IC50 172.0 nM
NC1=NC2(CCCC2)N(OCc2ccccc2)C(N)=N1 CHEMBL1824774 IC50 173.0 nM
CCc1nc(N)nc(N)c1C#CC(C)c1ccc(-c2ccccc2)cc1 CHEMBL3234321 IC50 174.0 nM
Nc1nc(N)c2c(Sc3ccc(O)cc3)cccc2n1 CHEMBL123353 I50 180.0 nM
COc1ccc(-c2cc(OC)cc(C(C)C#Cc3c(C)nc(N)nc3N)c2)cc1 CHEMBL572485 IC50 180.0 nM
CCc1nc(N)nc(N)c1C#CC(C)c1cnc(-c2ccccc2)nc1 CHEMBL3234324 IC50 180.0 nM
CCCN(Cc1ccc2nc(N)nc(N)c2c1)c1ccc(OC)c(OCCCCC(=O)OC)c1 CHEMBL1164234 Ki 188.0 nM
Cc1cc(Cc2cnc(N)nc2N)cc2c1OC(C)(C)C2 CHEMBL291540 I50 190.0 nM
Nc1nc(N)c2cc(Nc3ccccc3)cnc2n1 CHEMBL2382314 IC50 190.0 nM
Nc1nc(N)c2c(Sc3ccc(OC4CCOCC4)cc3)cccc2n1 CHEMBL121057 I50 200.0 nM
CCC(C#Cc1c(C)nc(N)nc1N)c1cc(OC)c(OC)c(OC)c1 CHEMBL574335 IC50 200.0 nM
CCOC(=O)CC[C@H](NC(=O)c1ccc(N(C)Cc2nc3cc(C(F)(F)F)ccc3nc2-c2ccccc2)cc1)C(=O)OCC CHEMBL3121472 Ki 200.0 nM
CCc1nc(N)nc(N)c1N1CCN(c2cccc(-c3ccccc3)c2)CC1 CHEMBL4582435 IC50 200.0 nM
CCc1nc(N)nc(N)c1C#CCc1cc(-c2ccc(C(=O)O)cc2)ccc1OC CHEMBL3827532 Ki 200.77 nM
CCc1nc(N)nc(N)c1C#CC(C)c1ccc(-c2ccc(C)cc2)cc1OC CHEMBL3234119 IC50 208.0 nM
Nc1nc(O)c2cc(NCc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)cnc2n1 CHEMBL157857 I50 210.0 nM
Cc1c(Sc2ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc2)[nH]c2nc(N)nc(N)c12 CHEMBL389643 IC50 210.0 nM
COc1cc(-c2ccc(C(C)(C)C)cc2)cc(C(C)C#Cc2c(C)nc(N)nc2N)c1 CHEMBL578424 IC50 210.0 nM
CN1C(=O)C(=Cc2cn(CC(O)Cn3c4ccccc4c(=O)c4ccccc43)c3ccccc23)C(=O)N(C)C1=O CHEMBL4544130 IC50 210.0 nM
CCc1nc(N)nc(N)c1Cc1ccc(-c2ccc(C(=O)O)cc2)cc1 CHEMBL5404134 Ki 214.41 nM
CCCCCCCCCc1cccc(N2C(N)=NC(N)=NC2(C)C)c1 CHEMBL20587 Log 1/Ki 218.78 nM
CCC(Cc1coc2nc(N)cc(N)c12)c1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1 CHEMBL56977 IC50 220.0 nM
CN(Cc1coc2nc(N)nc(N)c12)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 CHEMBL104829 IC50 220.0 nM
CN(Cc1coc2nc(N)nc(N)c12)c1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1 CHEMBL278515 IC50 220.0 nM
Nc1nc(N)c2c(CCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)coc2n1 CHEMBL323565 IC50 220.0 nM
Nc1nc(N)c2c(CNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)coc2n1 CHEMBL106628 IC50 220.0 nM
Cn1ccc2c3c(N)nc(N)nc3ccc21 CHEMBL174414 Ki 230.0 nM
CCc1cc(Cc2cnc(N)nc2N)cc(CC)c1CC CHEMBL57582 I50 230.0 nM
CCc1nc(N)nc(N)c1C#C[C@H](C)c1cc(OC)cc(-c2ccc(C(=O)O)cc2)c1 CHEMBL3828485 Ki 234.23 nM
Cc1cc2c(N)nc(N)nc2cc1-c1cnc2[nH]ccc2c1 CHEMBL3681409 Ki 235.0 nM
Cc1nc(N)nc(N)c1N1CCN(c2cccc(-c3ccccc3)c2)CC1 CHEMBL4459877 IC50 237.0 nM
CCOc1ccc2[nH]ccc2c1-c1cc2nc(N)nc(N)c2cc1C CHEMBL1818125 Ki 245.0 nM
Cc1cc2c(N)nc(N)nc2cc1-c1cccc2[nH]ccc12 CHEMBL3681400 Ki 245.0 nM
COc1ccc(OC)c(N(C)Cc2cccc3nc(N)nc(N)c23)c1 CHEMBL434097 Ki 250.0 nM
Cc1ccc(F)c(NCc2cnc3nc(N)nc(N)c3c2C)c1 CHEMBL348209 IC50 250.0 nM
CN(Cc1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1)c1cnc2nc(N)nc(O)c2c1 CHEMBL156551 I50 250.0 nM
CCc1nc(N)nc(N)c1C#CC(C)c1cc(OC)cc(N2CCOCC2)c1 CHEMBL2335417 IC50 250.0 nM
COc1ccccc1Nc1cnc2nc(N)nc(N)c2c1 CHEMBL2382316 IC50 250.0 nM
CS(=O)(=O)c1ccc(-c2ccc3c(N)nc(N)nc3c2)cc1 CHEMBL1818111 Ki 253.0 nM
O=C(O)CCC(NC(=O)c1ccc(OCc2ccc3ncnc(O)c3c2)cc1)C(=O)O CHEMBL354121 I50 260.0 nM
CCc1sc2nc(N)[nH]c(=O)c2c1Sc1ccc([N+](=O)[O-])cc1 CHEMBL564937 IC50 260.0 nM
CCc1sc2nc(N)[nH]c(=O)c2c1Sc1ccc(Br)cc1 CHEMBL565179 IC50 260.0 nM
CCc1nc(N)nc(N)c1C#CC(C)c1cc(OC)cc(-c2ccc3c(c2)OCCO3)c1 CHEMBL2335423 IC50 260.0 nM
CC(=O)Nc1nc(C(=O)NNC(=O)CCN2CCCCC2)cs1 CHEMBL5282535 IC50 262.0 nM
Cc1cc2nc(-c3ccc4c(N)nc(N)nc4c3)n(CCCO)c2cc1C CHEMBL3681405 Ki 263.0 nM
Nc1nc(N)c2c(Sc3cccc(Cl)c3)cccc2n1 CHEMBL338742 I50 270.0 nM
Cc1c(CNc2ccccc2OC(F)F)cnc2nc(N)nc(N)c12 CHEMBL347088 IC50 277.0 nM
Nc1nc(O)c2cc(N(C=O)Cc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)ccc2n1 CHEMBL77065 I50 280.0 nM
CCc1sc2nc(N)[nH]c(=O)c2c1Sc1cc(Cl)cc(Cl)c1 CHEMBL560912 IC50 280.0 nM
NS(=O)(=O)c1ccc(N2C(=O)/C(=C/c3ccc(OC(=O)c4ccccc4)cc3)N=C2c2ccccc2)cc1 CHEMBL5271705 IC50 280.0 nM
COc1cc(/C=C2\N=C(c3ccccc3)N(c3ccc(S(N)(=O)=O)cc3)C2=O)ccc1OC(=O)c1ccccc1 CHEMBL5276096 IC50 280.0 nM
COc1cc(/C=C2\N=C(c3ccccc3)N(c3ccc(C(=O)O)cc3)C2=O)ccc1OC(=O)c1ccccc1 CHEMBL5286217 IC50 280.0 nM
O=C(Nc1c(F)c(F)c(-c2ccccc2)c(F)c1F)c1nonc1O CHEMBL1946659 IC50 289.0 nM
C#CN(Cc1ccc2nc(N)nc(O)c2c1)c1ccc(C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)NC(CCC(=O)NC(CCC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O)C(=O)O)C(=O)O)cc1 CHEMBL1160181 IC50 290.0 nM
CCc1sc2nc(N)[nH]c(=O)c2c1Sc1ccc(Cl)c(Cl)c1 CHEMBL556091 IC50 290.0 nM
COc1cc(C(C#Cc2c(C)nc(N)nc2N)C(C)C)cc(OC)c1OC CHEMBL582843 IC50 290.0 nM
COc1cc(C(C)(C)C#Cc2c(C)nc(N)nc2N)cc(OC)c1OC CHEMBL1230365 IC50 290.0 nM
CCc1nc(N)nc(N)c1C#CCc1cccc(-c2ccccc2)c1 CHEMBL1270439 IC50 290.0 nM
CCc1nc(N)nc(N)c1C#CCc1cccc(-c2cccnc2)c1 CHEMBL3644522 IC50 290.0 nM
COc1cc(CCc2ccc3nc(N)nc(N)c3n2)cc(OC)c1OC CHEMBL4071461 IC50 290.0 nM
CC(=O)NNC(=O)c1csc2ncc(-c3ccc(Br)cc3)n12 CHEMBL5204417 IC50 291.0 nM
C#CCN(Cc1ccc2[nH]c(N)nc(=O)c2c1)c1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1 CHEMBL422395 IC50 300.0 nM
CN(Cc1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1)c1ccc2nc(N)nc(O)c2c1 CHEMBL74659 I50 300.0 nM
COc1cc(C)c2ccc(Cc3cnc(N)nc3N)cc2n1 CHEMBL294377 I50 300.0 nM
C#CN(Cc1ccc2nc(N)nc(O)c2c1)c1ccc(C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)NC(CCC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O)C(=O)O)cc1 CHEMBL1160192 IC50 300.0 nM
COc1ccc(C)cc1NCc1cnc2nc(N)nc(N)c2c1C CHEMBL279705 IC50 300.0 nM
Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1 CHEMBL425048 IC50 300.0 nM
CCc1sc2nc(N)[nH]c(=O)c2c1Sc1ccc(Cl)cc1 CHEMBL564277 IC50 300.0 nM
CCc1sc2nc(N)[nH]c(=O)c2c1Sc1cccc(Cl)c1 CHEMBL551985 IC50 300.0 nM
CCc1nc(N)nc(N)c1C#CCc1cc(-c2ccccc2)ccc1OC CHEMBL1270533 IC50 300.0 nM
Nc1ccc2c(c1)/C(=C/c1cn(CC(O)Cn3cc(/C=C4\C(=O)Nc5ccc(N)cc54)c4ccccc43)c3ccccc13)C(=O)N2 CHEMBL3786413 IC50 300.0 nM
Nc1ncc(N2CCN(c3cccc(-c4cccnc4)c3)CC2)c(N)n1 CHEMBL4461133 IC50 300.0 nM
CCCCCCCCCCCCc1cccc(N2C(N)=NC(N)=NC2(C)C)c1 CHEMBL21254 Log 1/Ki 302.0 nM
COc1ncc(-c2cccc(N3CCN(c4cnc(N)nc4N)CC3)c2)cn1 CHEMBL4468777 IC50 308.0 nM
CCc1cc(Cc2cnc(N)nc2N)cc(C)c1OC CHEMBL23447 I50 310.0 nM
COc1cc(NCc2cccc3nc(N)nc(N)c23)cc(OC)c1OC CHEMBL165955 Ki 310.0 nM
Cc1nc2cc(Nc3nc(Nc4ccc(F)cc4)nc(N4CCN(C)CC4)n3)ccc2n1Cc1ccccc1 CHEMBL3747446 IC50 310.0 nM
Cc1nc2ccc(Nc3nc(Cl)nc(Nc4ccc(F)cc4)n3)cc2n1Cc1ccccc1 CHEMBL3746172 IC50 310.0 nM
COc1cc(C(C)C#Cc2c(C)nc(N)nc2N)c(OC)cc1-c1ccccc1 CHEMBL1270734 IC50 314.0 nM
Cc1ccc2c(c1)nc(-c1cccs1)n2-c1ccc2c(N)nc(N)nc2c1 CHEMBL3686067 Ki 314.0 nM
Nc1ccc(Sc2cccc3nc(N)nc(N)c23)cc1 CHEMBL333769 I50 320.0 nM
O=C(O)CCC(NC(=O)c1ccc(CNc2ccc3ncnc(O)c3c2)cc1)C(=O)O CHEMBL169376 I50 320.0 nM
Nc1nc(N)c2cc(NCc3ccc(C(=O)NC(=O)[C@H](N)CCC(=O)O)cc3)cnc2n1 CHEMBL33045 IC50 320.0 nM
COc1cc2nc(-c3nccs3)n(-c3cc4nc(N)nc(N)c4cc3Cl)c2cc1OC CHEMBL3128018 Ki 320.0 nM
COc1cc2c(cc1CO)nc(-c1nccs1)n2-c1cc2nc(N)nc(N)c2cc1Cl CHEMBL3681407 Ki 320.0 nM
COc1ccc(-c2nc(Nc3ccc(F)cc3)nc(Nc3ccc4c(c3)nc(C)n4Cc3ccccc3)n2)cc1 CHEMBL3746201 IC50 320.0 nM
CC(=O)c1cccc(-c2ccc3c(N)nc(N)nc3c2)c1 CHEMBL1818119 Ki 323.0 nM
Nc1nc(=O)c2cc(CSc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)ccc2[nH]1 CHEMBL138870 I50 330.0 nM
CCc1nc(N)nc(N)c1C#CCc1cc(-c2ccncc2)ccc1OC CHEMBL3526249 IC50 330.0 nM
C#CN(Cc1ccc2nc(N)nc(O)c2c1)c1ccc(C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)O)cc1 CHEMBL1160189 IC50 340.0 nM
COc1cc(Cc2cnc(N)nc2N)cc2c1OCCN2 CHEMBL2012911 IC50 340.0 nM
CN(c1ccc([N+](=O)[O-])cc1)c1cnc2nc(N)nc(N)c2c1 CHEMBL2382333 IC50 340.0 nM
COc1cc(-c2ccccc2)ccc1C(C)C#Cc1c(C)nc(N)nc1N CHEMBL1270837 IC50 340.0 nM
COc1ccc(OC)c(-c2ccc3c(N)nc(N)nc3c2)c1 CHEMBL3681398 Ki 345.0 nM
CCc1nc(N)nc(N)c1C#CCc1cc(-c2cccc(C(=O)O)c2)ccc1OC CHEMBL3828724 Ki 346.15 nM
Nc1ncc(N2CCN(c3ccc(-c4ccccc4)cc3)CC2)c(N)n1 CHEMBL4552468 IC50 347.0 nM
CCc1sc2nc(N)[nH]c(=O)c2c1Sc1ccncc1 CHEMBL550842 IC50 350.0 nM
CCc1nc(N)nc(N)c1C#CCc1ccccc1 CHEMBL501263 IC50 360.0 nM
COc1c(C)cc(Cc2cnc(N)nc2N)cc1C CHEMBL287553 I50 370.0 nM
C#CN(Cc1ccc2nc(N)nc(O)c2c1)c1ccc(C(=O)NC(CCC(=O)NC(CCC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O)C(=O)O)cc1 CHEMBL1160188 IC50 370.0 nM
CCc1c(CNc2cc(C)ccc2OC)cnc2nc(N)nc(N)c12 CHEMBL358381 IC50 370.0 nM
CCc1nc(N)nc(N)c1C#C[C@H](C)c1cc(-c2ccc(C(=O)O)cc2)ccc1OC CHEMBL3827326 Ki 376.62 nM
COc1ccc(-c2nc3c(N)nc(N)nc3nc2C(C)C)cc1 CHEMBL531405 IC50 382.1 nM
C/C(O)=C(\C#N)C(=O)Nc1ccc(C(F)(F)F)cc1 CHEMBL973 IC50 388.0 nM
CCc1nc(N)nc(N)c1C#C[C@@H](C)c1cc(OC)cc(-c2ccc(C(=O)O)cc2)c1 CHEMBL3828581 Ki 388.62 nM
COc1ccccc1Sc1cccc2nc(N)nc(N)c12 CHEMBL121303 I50 400.0 nM
Nc1nc(O)c2cc(CNc3ccc(C(=O)NC(CCS(=O)(=O)O)C(=O)O)cc3)cnc2n1 CHEMBL39175 IC50 400.0 nM
COc1cc(CC#Cc2c(C)nc(N)nc2N)cc(OC)c1OC CHEMBL220159 IC50 400.0 nM
COc1ccc(OC)c(C(C)C#Cc2c(C)nc(N)nc2N)c1 CHEMBL574329 IC50 400.0 nM
COc1cc(C(C)C#Cc2c(C)nc(N)nc2N)cc(N2CCOCC2)c1 CHEMBL2335416 IC50 400.0 nM
CC(Cc1coc2nc(N)cc(N)c12)c1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1 CHEMBL60639 IC50 420.0 nM
CC(Cc1coc2nc(N)nc(N)c12)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 CHEMBL430872 IC50 420.0 nM
Cc1c(CSc2cccc(Cl)c2)cnc2nc(N)nc(N)c12 CHEMBL24007 IC50 420.0 nM
CCc1[nH]c2nc(N)nc(O)c2c1Sc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 CHEMBL371860 IC50 420.0 nM
C=CCN1c2c(N)nc(N)nc2CCC1CN(C)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 CHEMBL2153705 IC50 420.0 nM
CCc1nc(N)nc(N)c1Cc1ccc(-c2ccc(C(=O)OC)cc2)cc1 CHEMBL5440218 Ki 422.92 nM
NCCCC(NC(=O)c1ccc(NCc2ccc3nc(N)nc(O)c3c2Cl)cc1)C(=O)O CHEMBL288142 I50 430.0 nM
Cc1cc2nc(-c3ccncc3)n(-c3ccc4c(N)nc(N)nc4c3)c2cc1C CHEMBL3127914 Ki 437.0 nM
COc1ccc(SCc2cnc3nc(N)nc(N)c3c2C)cc1OC CHEMBL23244 IC50 440.0 nM
Cc1c(CSc2cccc3ccccc23)cnc2nc(N)nc(N)c12 CHEMBL23584 IC50 440.0 nM
CC1c2cc(Cc3ccccc3)c(-c3ccccc3)n2CCN1Cc1cnc(N)nc1N CHEMBL77758 IC50 450.0 nM
Nc1nc(N)c2c(CNc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)coc2n1 CHEMBL17383 IC50 450.0 nM
Nc1nc(N)c2cc(Nc3cc(F)ccc3F)cnc2n1 CHEMBL2382324 IC50 450.0 nM
COc1cccc(CCc2ccc3nc(N)nc(N)c3n2)c1 CHEMBL4062835 IC50 450.0 nM
CCc1nc(N)nc(N)c1C#C[C@@H](C)c1cc(-c2ccc(C(=O)O)cc2)ccc1OC CHEMBL3827760 Ki 451.15 nM
N#CCN(Cc1ccc2nc(N)nc(O)c2c1)c1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1 CHEMBL34918 IC50 460.0 nM
Cc1c(NCc2ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc2)ccc2nc(N)nc(O)c12 CHEMBL35936 I50 460.0 nM
Nc1ncc(N2CCN(c3cccc(-c4ccncc4)c3)CC2)c(N)n1 CHEMBL4591654 IC50 468.0 nM
CCc1nc(N)nc(N)c1C#CC(C)c1ccc(-c2ccc(C#N)cc2)cc1OC CHEMBL3234120 IC50 477.0 nM
COc1cccc(SCc2cnc3nc(N)nc(N)c3c2C)c1 CHEMBL277217 IC50 500.0 nM
CC1=CN(C)C2=NC(N)NC(=O)C2=C1 CHEMBL436184 Kd 500.0 nM
COc1ccccc1/C(C)=C\c1coc2nc(N)nc(N)c12 CHEMBL606039 Ki 500.0 nM
O=C(/C=C/c1ccccc1)Nc1ccc2nc(SC/C=C/c3ccccc3)n(Cc3ccccc3)c(=O)c2c1 CHEMBL1089229 IC50 500.0 nM
C=CCSc1nc2ccc(NC(=O)/C=C/c3ccccc3)cc2c(=O)n1Cc1ccccc1 CHEMBL1093519 IC50 500.0 nM
COc1cc(/C=C2\CCCc3c2nc(C)nc3-c2cc(OC)c(OC)c(OC)c2)cc(OC)c1OC CHEMBL3115731 IC50 500.0 nM
COc1cc(/C=C2\C(=O)Nc3ccccc32)cc(OC)c1O CHEMBL2163553 IC50 500.0 nM
Nc1nc(N)c(-c2ccccc2)c(COc2cccc(OCC(=O)O)c2)n1 CHEMBL4459356 Ki 508.88 nM
CCn1c(Sc2cccc(OC)c2)c(C)c2c(N)nc(N)nc21 CHEMBL4227124 IC50 511.0 nM
CCc1nc(N)nc(N)c1C#CCc1cccc(-c2ccncc2)c1 CHEMBL3644521 IC50 520.0 nM
NCCCC(NC(=O)c1ccc(OCc2ccc3nc(N)nc(O)c3c2)cc1)C(=O)O CHEMBL289372 I50 530.0 nM
COc1ccc(Cc2cnc(N)nc2N)cc1OC CHEMBL19633 I50 530.0 nM
COc1ccc(CN(C)c2cnc3nc(N)nc(N)c3c2)c(OC)c1OC CHEMBL35222 IC50 530.0 nM
NC1=NC2(CCN(C(=O)Nc3ccc(F)cc3)CC2)N(c2cccc(Cl)c2)C(N)=N1 CHEMBL4170787 Ki 530.0 nM
CC1=C(C(=O)Nc2ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc2)C(c2ccc(Cl)cc2)NC(=O)N1 CHEMBL4748158 IC50 530.0 nM
COc1cc(C)nc2c(OC)cc(Cc3cnc(N)nc3N)cc12 CHEMBL56719 I50 540.0 nM
CCc1sc2nc(N)[nH]c(=O)c2c1Sc1cc(OC)cc(OC)c1 CHEMBL563212 IC50 540.0 nM
Nc1ncc(N2CCN(c3cccc(C(F)(F)F)c3)CC2)c(N)n1 CHEMBL4535103 IC50 541.0 nM
NC1=NC(C2CC2)N(OCc2ccccc2)C(N)=N1 CHEMBL1824772 IC50 548.0 nM
CCCCCCc1ccc(Sc2cccc3nc(N)nc(N)c23)cc1 CHEMBL121595 I50 550.0 nM
Nc1nc(N)c(-c2ccccc2)c(COc2cccc(OCCCC(=O)O)c2)n1 CHEMBL4441455 Ki 555.55 nM
Cc1sc2nc(N)[nH]c(=O)c2c1Sc1ccc([N+](=O)[O-])cc1 CHEMBL492836 IC50 560.0 nM
Nc1nc(N)c2c(n1)CCC(CNc1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1)N2 CHEMBL476400 IC50 560.0 nM
Cc1cc2nc(-c3ccccn3)n(-c3ccc4c(N)nc(N)nc4c3)c2cc1C CHEMBL3127912 Ki 572.0 nM
COc1cccc(Sc2c(C)c3c(N)nc(N)nc3n2C(C)C)c1 CHEMBL4227384 IC50 579.0 nM
CCOC(=O)C1=C(C)NC(=S)NC1c1ccccc1 CHEMBL455456 IC50 580.0 nM
COc1ccc(-c2c(CN3CCOCC3)nc3scc(C(=O)NN)n23)cc1 CHEMBL5173449 IC50 585.0 nM
COc1ccc2nc(SCCC(C)(F)F)n(-c3ccc4c(N)nc(N)nc4c3)c2c1 CHEMBL3681406 Ki 586.0 nM
Cc1c(CSc2ccc(Cl)cc2)cnc2nc(N)nc(N)c12 CHEMBL22677 IC50 590.0 nM
Nc1nc(N)c2nc(CNc3ccc(C(=O)N4CCC(C(=O)O)CC4)cc3)cnc2n1 CHEMBL2178604 Ki 590.0 nM
Nc1nc(N)c2nc(/C=C/Cc3ccccc3)ccc2n1 CHEMBL4227213 IC50 590.0 nM
O=C(Nc1c(F)c(F)c(-c2cccc(OC(F)(F)F)c2)c(F)c1F)c1nonc1O CHEMBL1946851 IC50 599.0 nM
Nc1nc(N)c2cc(NCc3cccc4c3CCCC4)ccc2n1 CHEMBL114839 IC50 600.0 nM
CC(C)CN1C=CC=C2C(=O)NC(N)N=C21 CHEMBL336628 Kd 600.0 nM
COc1cc(Nc2nc3cc(N)cc(N)c3nc2-c2ccccc2)cc(OC)c1 CHEMBL464844 Ki 600.0 nM
CCc1sc2nc(N)[nH]c(=O)c2c1Sc1ccccc1Cl CHEMBL551768 IC50 600.0 nM
COc1cc2nc(-c3ccco3)n(-c3cc4nc(N)nc(N)c4cc3Cl)c2cc1OC CHEMBL3127909 Ki 610.0 nM
Nc1nc(N)c2nc(CCCCc3ccccc3)ccc2n1 CHEMBL4227155 IC50 610.0 nM
Nc1nc(N)c2c(Sc3ccccc3)cccc2n1 CHEMBL100239 I50 620.0 nM
CCc1sc2nc(N)[nH]c(=O)c2c1Sc1ccc(F)cc1 CHEMBL538143 IC50 620.0 nM
COc1ccccc1Sc1[nH]c2nc(N)nc(N)c2c1C CHEMBL331314 IC50 624.0 nM
CCc1nc(N)nc(N)c1C#CC(C)c1ccc(-c2ccc(C)cc2)nc1 CHEMBL3234323 IC50 625.0 nM
Cc1cc(N2CCOCC2)nc2cc(Cc3cnc(N)nc3N)ccc12 CHEMBL56325 I50 630.0 nM
Nc1nc(N)c2c(OCc3cc(F)cc(F)c3)cccc2n1 CHEMBL398675 IC50 630.0 nM
C#CN(Cc1ccc2nc(N)nc(O)c2c1)c1ccc(C(=O)NC(CCC=O)C(=O)O)cc1 CHEMBL1160200 IC50 640.0 nM
Nc1nc2[nH]cc(Cc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)c2c(=O)[nH]1 CHEMBL2426247 IC50 640.0 nM
Cc1ccc(C(=O)N2CCC3(CC2)N=C(N)N=C(N)N3c2cccc(Cl)c2)cc1 CHEMBL4167391 Ki 640.0 nM
O=C(O)CCC(NC(=O)c1ccc(SCc2ccc3ncnc(O)c3c2)cc1)C(=O)O CHEMBL171790 I50 650.0 nM
CN(Cc1ccc(C(=O)NC(=O)[C@H](N)CCC(=O)O)cc1)c1cnc2nc(N)nc(N)c2c1 CHEMBL33815 IC50 650.0 nM
COc1ccccc1C(Cc1coc2nc(N)nc(N)c12)C1CC1 CHEMBL603198 Ki 650.0 nM
Cc1cc2nc(-c3ccsc3)n(-c3ccc4c(N)nc(N)nc4c3)c2cc1C CHEMBL3128026 Ki 663.0 nM
Nc1nc(N)c2cc(CNc3ccc(Cl)cc3)cnc2n1 CHEMBL23492 IC50 670.0 nM
C[C@H](NC(=O)CNC(=O)c1cccc2c(=O)c3ccccc3[nH]c12)C(=O)O CHEMBL4581410 IC50 670.0 nM
CC(=O)Nc1nc(C(=O)NNC(=O)CCN2CCN(C)CC2)cs1 CHEMBL5276173 IC50 678.0 nM
CCc1nc(N)nc(N)c1C#CC(C)c1ccc(-c2ccccc2)nc1 CHEMBL3234322 IC50 688.0 nM
Nc1ncc(N2CCN(c3cccc(-c4ccccc4)c3)CC2)c(N)n1 CHEMBL3953119 IC50 689.0 nM
CC1=C2C(=O)NC(N)N=C2N(CCC(C)C)C=C1 CHEMBL135936 Kd 700.0 nM
NC1N=C2C(=CC=CN2Cc2ccccc2)C(=O)N1 CHEMBL134613 Kd 700.0 nM
CN(Cc1ccccc1)c1cnc2nc(N)nc(N)c2c1 CHEMBL33038 IC50 700.0 nM
C=CCSc1nc2ccc(N(C/C=C/c3ccccc3)C/C=C/c3ccccc3)cc2c(=O)n1Cc1ccccc1 CHEMBL1093994 IC50 700.0 nM
O=C1Nc2ccc([N+](=O)[O-])cc2/C1=C/c1cn(CC(O)Cn2cc(/C=C3\C(=O)Nc4ccc([N+](=O)[O-])cc43)c3ccccc32)c2ccccc12 CHEMBL3785463 IC50 700.0 nM
Nc1nc(N)c2nc(CCCCCc3ccccc3)ccc2n1 CHEMBL4227367 IC50 700.0 nM
Nc1ccc(-c2ccc3c(N)nc(N)nc3c2)cc1 CHEMBL1818109 Ki 702.0 nM
Cc1c(CN(C)c2cccc3c2CCCC3)cnc2nc(N)nc(N)c12 CHEMBL23220 IC50 710.0 nM
COc1ccc(CCc2ccc3nc(N)nc(N)c3n2)cc1 CHEMBL4090780 IC50 710.0 nM
Cc1nc2cc(Nc3nc(Nc4ccc(F)cc4)nc(-c4cccs4)n3)ccc2n1Cc1ccccc1 CHEMBL3746824 IC50 720.0 nM
Cc1cc2nc(-c3ccoc3)n(-c3ccc4c(N)nc(N)nc4c3)c2cc1C CHEMBL3128024 Ki 723.0 nM
COc1ccc(OC)c(Cc2sc3nc(N)nc(N)c3c2C)c1 CHEMBL104787 IC50 730.0 nM
Nc1nc(N)c2nc(COc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)cnc2n1 CHEMBL10804 I50 740.0 nM
Nc1nc(N)c2ccc(-c3ccccc3)cc2n1 CHEMBL1818107 Ki 743.0 nM
Cc1cc2nc(C3CCCO3)n(-c3ccc4c(N)nc(N)nc4c3)c2cc1C CHEMBL3127919 Ki 749.0 nM
COc1ccc(OC)c(-c2sc3nc(N)nc(N)c3c2C)c1 CHEMBL323960 IC50 750.0 nM
Nc1ncc(Cc2cccc(O)c2)c(N)n1 CHEMBL30734 Ki 750.0 nM
NCCCC(NC(=O)c1ccc(NCc2ccc3nc(N)nc(O)c3c2)cc1)C(=O)O CHEMBL35807 IC50 750.0 nM
COc1cc(-c2cc(C)cc(C)c2)cc(C(C)C#Cc2c(C)nc(N)nc2N)c1 CHEMBL575217 IC50 750.0 nM
COc1ccccc1C(Cc1coc2nc(N)nc(N)c12)C(C)C CHEMBL595757 Ki 770.0 nM
CC1(C)N=C(N)N=C(N)N1c1cccc(OCC23CC4CC(CC(C4)C2)C3)c1 CHEMBL281618 Log 1/Ki 776.25 nM
COc1ccc2nc(-c3ccco3)n(-c3ccc4c(N)nc(N)nc4c3)c2n1 CHEMBL3686068 Ki 797.0 nM
Cc1nc(N)nc2[nH]cc(CCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)c12 CHEMBL439973 IC50 800.0 nM
CSc1nc2ccc(N(C/C=C/c3ccccc3)C/C=C/c3ccccc3)cc2c(=O)n1Cc1ccccc1 CHEMBL1090563 IC50 800.0 nM
C=CCNc1ccc2nc(SC)n(Cc3ccccc3)c(=O)c2c1 CHEMBL1089230 IC50 800.0 nM
Nc1nc(N)c2c(n1)CCC1CN(c3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)CN21 CHEMBL2153704 IC50 800.0 nM
COC(=O)C1CCN(C(=O)c2ccc(N(C)Cc3cnc4nc(N)nc(N)c4n3)cc2)CC1 CHEMBL1232702 Ki 800.0 nM
Nc1nc(N)c2nc3c(nc2n1)-c1cccc2cccc-3c12 CHEMBL4641198 IC50 810.0 nM
CC1=C(C(=O)Nc2ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc2)C(c2ccc([N+](=O)[O-])cc2)NC(=O)N1 CHEMBL4791810 IC50 810.0 nM
Cc1c(Sc2ccc(OC(F)(F)F)cc2)[nH]c2nc(N)nc(N)c12 CHEMBL4226262 IC50 811.0 nM
Nc1ncc(N2CCN(c3cccc(OC(F)(F)F)c3)CC2)c(N)n1 CHEMBL4439025 IC50 819.0 nM
CCOc1ccc2nc(N)nc(N)c2c1Sc1ccc(C(C)(C)C)cc1 CHEMBL420721 I50 820.0 nM
Nc1nc(N)c2cc(CNc3cccc4ccccc34)cnc2n1 CHEMBL22924 IC50 820.0 nM
COc1ccccc1C(=Cc1coc2nc(=N)[nH]c(N)c12)C(C)C CHEMBL594810 Ki 830.0 nM
CCOC(=O)CSC1=NC(c2ccccc2)C(C(=O)OCC)=C(C)N1 CHEMBL2261694 IC50 830.0 nM
CCc1sc2nc(N)[nH]c(=O)c2c1Sc1cc(OC)ccc1OC CHEMBL564004 IC50 840.0 nM
CC1=C(C(=O)Nc2ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc2)C(c2ccccc2)NC(=O)N1 CHEMBL4743204 IC50 840.0 nM
COc1cc2nc(-c3ccccn3)n(-c3ccc4c(N)nc(N)nc4c3)c2cc1OC CHEMBL3127910 Ki 841.0 nM
Cc1cc(C)c(NCc2cnc3nc(N)nc(N)c3c2C)c(Cl)c1 CHEMBL147458 IC50 850.0 nM
Cc1cccc(SCc2cnc3nc(N)nc(N)c3c2C)c1 CHEMBL23272 IC50 850.0 nM
Cn1nc(O)c(C(=O)Nc2c(F)cc(-c3ccccc3)cc2F)n1 CHEMBL4061824 IC50 853.0 nM
COc1cc2nc(-c3nccs3)n(-c3ccc4c(N)nc(N)nc4c3)c2cc1OC CHEMBL3128016 Ki 854.0 nM
COc1cc2c(cc1CO)nc(-c1nccs1)n2-c1ccc2c(N)nc(N)nc2c1 CHEMBL3681414 Ki 854.0 nM
C=CCSc1nc2ccc(N(CC=C)CC=C)cc2c(=O)n1Cc1ccccc1 CHEMBL1093230 IC50 900.0 nM
CCCCN(c1ccccc1)c1ccc2nc(N)nc(N)c2n1 CHEMBL4440383 IC50 903.0 nM
Cc1ccc(-c2c(CN3CCCCC3)nc3scc(C(=O)O)n23)cc1 CHEMBL5194543 IC50 907.0 nM
CCc1[nH]c(N)nc2ncc(CCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)c1-2 CHEMBL157434 IC50 920.0 nM
Cc1nc(N)nc(N)c1CN1CCN(c2cccc(-c3cccc(C#N)c3)c2)CC1 CHEMBL3901807 IC50 920.0 nM
Cc1ncc(-c2cccc(N3CCN(c4cnc(N)nc4N)CC3)c2)cn1 CHEMBL4543226 IC50 935.0 nM
Cc1ccc(Sc2cccc3nc(N)nc(N)c23)cc1 CHEMBL83547 I50 940.0 nM
CN(c1ccccc1)c1ccc2nc(N)nc(N)c2n1 CHEMBL140940 IC50 942.0 nM
Cc1cc2nc(-c3ccco3)n(-c3ccc4c(N)nc(N)nc4c3)c2cc1C CHEMBL3128023 Ki 943.0 nM
Nc1nc(N)c2nc(CCc3ccc(F)cc3)ccc2n1 CHEMBL4095728 IC50 950.0 nM
COc1cccc(Sc2[nH]c3nc(N)nc(N)c3c2C)c1 CHEMBL123984 IC50 970.0 nM
Cc1c(Sc2ccc3ccccc3c2)n(C)c2nc(N)nc(N)c12 CHEMBL4227373 IC50 970.0 nM
Nc1ncc(N2CCN(c3cccc(-c4cnc(C5CC5)nc4)c3)CC2)c(N)n1 CHEMBL4550110 IC50 973.0 nM
CCCCCCCCc1ccc(N2C(N)=NC(N)=NC2(C)C)cc1 CHEMBL176987 Log 1/Ki 977.24 nM
COc1cc(CCc2cnc3nc(N)nc(N)c3c2C)cc(OC)c1 CHEMBL151543 IC50 990.0 nM