CONC(=O)c1c(C)c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc12 CHEMBL4744558 IC50 0.12 nM
Cc1ccccc1NC(=O)c1cc(F)c(-c2cn(C)c(C(C)(C)O)n2)cc1O[C@@H](C)C(F)(F)F CHEMBL5077700 IC50 0.179 nM
Cc1ccccc1-n1cc(C(C)C)c2cc(-c3ccc(C)c(N)n3)c(F)cc2c1=O CHEMBL5405642 IC50 0.18 nM
C[C@H](Oc1cc(-c2cn(C)c(C(C)(C)O)n2)c(F)cc1C(=O)Nc1c(F)cccc1Cl)C(F)(F)F CHEMBL5085549 IC50 0.19 nM
Cc1n[nH]c(C(F)(F)F)c1NC(=O)c1cc(F)c(-c2ccc(Cl)c(N)n2)cc1O[C@@H](C)C(F)(F)F CHEMBL5075013 IC50 0.192 nM
Cc1ccc(-c2cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(F)cccc3Cl)cc2F)nc1N CHEMBL5083643 IC50 0.195 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c3c(Oc4c(F)cccc4Cl)nncc3c2F)c1=O CHEMBL4854356 IC50 0.2 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(F)cccc3Cl)cc2F)c1=O CHEMBL5180161 IC50 0.2 nM
C[C@H](Oc1cc(-c2ccc3c(n2)NCCC3)c(F)cc1C(=O)Nc1c(F)cccc1Cl)C(F)(F)F CHEMBL5092899 IC50 0.202 nM
Cc1cn(-c2cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(C)n[nH]c3Cl)cc2F)nc1[C@@H](C)O CHEMBL5428953 IC50 0.22 nM
CCn1c(CO)nn(-c2cc3c(C(C)C)cn(-c4c(F)cccc4Cl)c(=O)c3cc2F)c1=O CHEMBL4791380 IC50 0.222 nM
[2H]C([2H])([2H])c1ccccc1NC(=O)c1cc(F)c(-c2cn(C)c(C(C)(C)O)n2)cc1O[C@@H](C)C(F)(F)F CHEMBL5073905 IC50 0.225 nM
C=C(C)c1cn(-c2cc(F)ccc2C)c(=O)c2cc(F)c(-n3nc(CO)n(CC)c3=O)cc12 CHEMBL4753279 IC50 0.249 nM
Cc1cn(-c2cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(C)n[nH]c3Cl)cc2F)nc1[C@H](C)O CHEMBL5439317 IC50 0.26 nM
C=C(C)c1cn(-c2c(F)cccc2Cl)c(=O)c2cc(F)c(-n3nc(CO)n(CC)c3=O)cc12 CHEMBL4745588 IC50 0.265 nM
C=C(C)c1cn(-c2c(F)ccc(OC)c2Cl)c(=O)c2cc(F)c(-n3nc(CO)n(CC)c3=O)cc12 CHEMBL4752247 IC50 0.267 nM
CCn1c(CO)nn(-c2cc(O[C@@H](C)C(F)(F)F)c3c(Oc4c(F)ccc(OC)c4Cl)nccc3c2)c1=O CHEMBL4852401 IC50 0.3 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(Cl)ccnc3OC)cc2F)c1=O CHEMBL5171223 IC50 0.3 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(C)cnc(OC)c3Cl)cc2F)c1=O CHEMBL5193821 IC50 0.3 nM
Cc1cn(-c2cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(F)cccc3Cl)cc2F)nc1[C@H](C)O CHEMBL5437916 IC50 0.3 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c3c(Nc4c(F)cccc4Cl)nncc3c2F)c1=O CHEMBL4851260 IC50 0.38 nM
Cc1cn(-c2cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(C)n[nH]c3Cl)cc2F)nc1C(C)(C)O CHEMBL5431927 IC50 0.38 nM
Cc1ccccc1-n1cc(C(C)C)c2cc(-c3cn(C)c(C(C)(C)O)n3)c(F)cc2c1=O CHEMBL5416427 IC50 0.38 nM
CCn1c(CO)nn(-c2cc3c(C(C)C)cn(-c4ccccc4C)c(=O)c3cc2F)c1=O CHEMBL4751399 IC50 0.396 nM
CCn1c(CO)nn(-c2cc(O[C@@H](C)C(F)(F)F)c3c(Oc4c(F)ccc(N(C)C)c4Cl)nccc3c2)c1=O CHEMBL4859161 IC50 0.4 nM
CCn1c(CO)nn(-c2cc(O[C@@H](C)C(F)(F)F)c3c(Oc4c(F)ccc(OCCOC)c4Cl)nccc3c2)c1=O CHEMBL4855859 IC50 0.41 nM
Cc1ccccc1-n1nc(C(C)C)c2cc(-c3cn(C)c(C(C)(C)O)n3)c(F)cc2c1=O CHEMBL5409068 IC50 0.45 nM
Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc2c1C(=O)O CHEMBL38434 IC50 0.48 nM
Cc1cn(-c2cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(F)cccc3Cl)cc2F)nc1[C@@H](C)O CHEMBL5419305 IC50 0.48 nM
CN(C)c1cccc(-c2c(F)cc(-n3nnc4c3C(=O)c3ccccc3C4=O)cc2F)c1 CHEMBL4647465 IC50 0.5 nM
CCn1c(CO)nn(-c2nc(OC(C)C)c(C(=O)Nc3c(F)cccc3Cl)cc2F)c1=O CHEMBL5187184 IC50 0.5 nM
Cc1cn(-c2cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(F)cccc3Cl)cc2F)nc1C(C)(C)O CHEMBL5411333 IC50 0.5 nM
Cc1ccccc1-n1cc(C(C)C)c2cc(-c3cn(C)c([C@@H](C)O)n3)c(F)cc2c1=O CHEMBL5419814 IC50 0.51 nM
[2H]C([2H])([2H])n1cc(-c2cc3c(C(C)C)cn(-c4ccccc4C)c(=O)c3cc2F)nc1C(C)(C)O CHEMBL5434365 IC50 0.54 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(C)cnc(OC)c3C)cc2F)c1=O CHEMBL5186161 IC50 0.56 nM
Cc1ccccc1-n1cc(C(C)C)c2cc(-c3nc(C(C)(C)O)n(C)n3)c(F)cc2c1=O CHEMBL5436904 IC50 0.57 nM
CCn1c(CO)nn(-c2nc(OC(C)C(F)(F)F)c3c(Oc4c(F)cccc4Cl)nccc3c2F)c1=O CHEMBL4857243 IC50 0.59 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(Cl)ccnc3Cl)cc2F)c1=O CHEMBL5198030 IC50 0.6 nM
CCc1cnc(-n2nc(OC(C)C)c(Oc3c(F)cccc3F)c2C)nc1 CHEMBL3409491 pIC50 0.7943 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(C)cc(OC)nc3Cl)cc2F)c1=O CHEMBL5206111 IC50 0.8 nM
O=C(O)c1[nH]c(=O)[nH]c(=O)c1CCc1ccc(-c2ccccc2)cc1 CHEMBL3974614 IC50 0.97 nM
COc1ccccc1-c1c(F)c(F)c(NC(=O)c2ccsc2C(=O)O)c(F)c1F CHEMBL199361 IC50 1.0 nM
Cc1cc(Oc2ccccc2)c(C(C)C)cc1-c1cc(C(=O)O)c2cc(F)ccc2n1 CHEMBL2385512 IC50 1.0 nM
Cc1cccc(-c2ccc(-c3cc(C(=O)O)c4nc(C)[nH]c4c3)cc2)c1 CHEMBL4798243 IC50 1.0 nM
Cc1nc2c(C(=O)O)cc(-c3ccc(-c4ccccc4CN4CCCC4)cc3)cc2[nH]1 CHEMBL4761259 IC50 1.0 nM
Cc1nc2c(C(=O)O)cc(-c3c(F)c(F)c(-c4ccccc4)c(F)c3F)cc2[nH]1 CHEMBL4793981 IC50 1.0 nM
Cc1nc2c(C(=O)O)cc(-c3c(F)c(F)c(-c4ccc(CN5CCCC(F)(F)C5)cc4)c(F)c3F)cc2[nH]1 CHEMBL4743372 IC50 1.0 nM
Cc1nc2c(C(=O)O)cc(-c3ccc(-n4c(C)ccc4C)cc3)cc2[nH]1 CHEMBL4760820 IC50 1.0 nM
Cc1ccnc(Cl)c1Nc1nn(C)c2c(F)c(-c3cn(C)c(C(C)(C)O)n3)cc(O[C@@H](C)C(F)(F)F)c12 CHEMBL5194307 IC50 1.0 nM
COc1ccc([C@H]2c3[nH]c4ccc(Cl)cc4c3C[C@@H]3C(=O)N(C4CCCCC4)C(=S)N23)cc1 CHEMBL5275789 EC50 1.0 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(C)ccnc3Cl)cc2F)c1=O CHEMBL5193591 IC50 1.1 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(F)cnc(OC)c3Cl)cc2F)c1=O CHEMBL5209113 IC50 1.1 nM
O=C(Nc1c(F)c(F)c(-c2ccccc2)c(F)c1F)c1c(O)nn2ccccc12 CHEMBL4173846 IC50 1.2 nM
Cc1ccccc1-n1ncc2c1CCC[C@H]2NC(=O)c1noc2c1CCCC2 CHEMBL4638219 IC50 1.2 nM
O=C1c2ccccc2C(=O)c2c1nnn2-c1cc(F)c(-c2cccc(CO)c2)c(F)c1 CHEMBL4637493 IC50 1.2 nM
O=C1c2ccccc2C(=O)c2c1nnn2-c1cc(F)c(-c2cc(CO)ccc2F)c(F)c1 CHEMBL4635115 IC50 1.2 nM
CCn1c(CO)nn(-c2cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(F)cccc3Cl)cc2F)c1=O CHEMBL5077508 IC50 1.2 nM
O=C(Nc1c(F)c(F)c(-c2cccs2)c(F)c1F)c1c(O)nn2ccccc12 CHEMBL5086254 IC50 1.35 nM
Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc2c1C(=O)NO CHEMBL4759615 IC50 1.4 nM
CCN(CC)C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(F)cccc2Cl)cc1F CHEMBL5419877 IC50 1.4 nM
O=C(Nc1c(F)c(F)c(-c2cccc(OC(F)(F)F)c2)c(F)c1F)c1ccsc1C(=O)O CHEMBL4580266 IC50 1.5 nM
COCc1cccc(-c2c(F)cc(-n3nnc4c3C(=O)c3ccccc3C4=O)cc2F)c1 CHEMBL4647629 IC50 1.6 nM
Cc1c(-c2ccc(-c3ccccc3)cc2)nc2ccccc2c1C(=O)O CHEMBL39448 Ki 1.7 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(Cl)ccnc3C)cc2F)c1=O CHEMBL5197263 IC50 1.9 nM
O=C(Nc1c(F)cc(-c2cccc(OC(F)(F)F)c2)cc1F)c1ccsc1C(=O)O CHEMBL202431 IC50 2.0 nM
CN(/N=C/c1ccc(F)cc1C(=O)O)c1nc(-c2ccccc2Cl)cs1 CHEMBL3959360 IC50 2.0 nM
O=C(O)c1cc(C2CC2)ccc1Nc1cnc(-c2ccccc2)c(C(F)(F)F)c1 CHEMBL3674660 IC50 2.0 nM
CCn1c(CO)nn(-c2cc(O[C@@H](C)C(F)(F)F)c3c(Nc4c(F)cccc4Cl)nn(C)c3c2F)c1=O CHEMBL5196409 IC50 2.0 nM
CCn1c(CO)nn(-c2cc(O[C@@H](C)C(F)(F)F)c3c(Nc4c(C)ccnc4Cl)nn(C)c3c2F)c1=O CHEMBL5174652 IC50 2.0 nM
CCn1c(CO)nn(-c2cc(O[C@@H](C)C(F)(F)F)c3c(Nc4c(F)cccc4Cl)noc3c2F)c1=O CHEMBL5197393 IC50 2.0 nM
O=C(Nc1c(F)c(F)c(-c2cccc(F)c2)c(F)c1F)c1c(O)nn2ccccc12 CHEMBL5092556 IC50 2.03 nM
O=C(N[C@@H]1CCCc2c1cnn2-c1ccccc1F)c1ncn2c1CCCC2 CHEMBL4637894 IC50 2.3 nM
O=C(Nc1c(F)c(F)c(-c2cccc(OC(F)(F)F)c2)c(F)c1F)c1c(O)nn2ccccc12 CHEMBL5090431 IC50 2.3 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(F)cncc3Cl)cc2F)c1=O CHEMBL5176109 IC50 2.3 nM
C[C@H](Oc1cc(NC(=O)N2CCCC2)c(F)cc1C(=O)Nc1c(F)cccc1Cl)C(F)(F)F CHEMBL5409064 IC50 2.3 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(C)ccnc3C(F)F)cc2F)c1=O CHEMBL5205042 IC50 2.4 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(C)ccnc3F)cc2F)c1=O CHEMBL5207423 IC50 2.4 nM
CCN(C)C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(F)cccc2Cl)cc1F CHEMBL5409267 IC50 2.4 nM
Cc1c(Oc2c(F)cccc2F)c(OC(C)C)nn1-c1ncc(C2CC2)cc1F CHEMBL3589752 IC50 2.5 nM
C/C(O)=C(\C#N)C(=O)Nc1ccc(-c2ccccc2Cl)c(Cl)c1 CHEMBL484780 Ki(app) 2.7 nM
Cc1cccc(-n2ncc3c2CCCC3NC(=O)c2noc3c2CCCC3)c1C CHEMBL4637264 IC50 2.7 nM
O=C1c2ccccc2C(=O)c2c1nnn2-c1cc(F)c(-c2cccc(F)c2)c(F)c1 CHEMBL4645385 IC50 2.7 nM
COc1cccc(-c2c(F)c(F)c(NC(=O)c3c(O)nn4ccccc34)c(F)c2F)c1 CHEMBL5084878 IC50 2.75 nM
O=C(Nc1c(F)c(F)c(-c2cccc(O)c2)c(F)c1F)c1c(O)nn2ccccc12 CHEMBL5088148 IC50 2.78 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3cccnc3Cl)cc2F)c1=O CHEMBL5197809 IC50 2.8 nM
CCN(C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(F)cccc2Cl)cc1F)C1CC1 CHEMBL5407738 IC50 2.8 nM
COc1cccc(-c2c(F)c(F)c(Nc3ncccc3C(=O)O)c(F)c2F)c1 CHEMBL2263625 pIC50 2.999 nM
CCOc1cccc(-c2cc(F)c(NC(=O)c3ccsc3C(=O)O)c(F)c2)c1 CHEMBL200699 IC50 3.0 nM
O=C(O)c1cc(C2CC2)ccc1Nc1cnc(-c2ccccc2Cl)nc1 CHEMBL3674666 IC50 3.0 nM
Cc1cc(C(=O)O)c2c(c1)nc(-c1c(F)c(F)c(-c3ccccc3)c(F)c1F)n2C CHEMBL3677808 IC50 3.0 nM
CCn1c(CO)nn(-c2cc(OC(C)C(F)(F)F)c3c(Nc4c(F)cccc4Cl)nn(C)c3c2F)c1=O CHEMBL5176259 IC50 3.0 nM
COc1ccc([C@H]2c3[nH]c4ccc(Br)cc4c3C[C@@H]3C(=O)N(C4CCCCC4)C(=S)N23)cc1 CHEMBL5274468 EC50 3.0 nM
Nc1cccc(-c2ccc(-n3nnc4c3C(=O)c3ccccc3C4=O)cc2)c1 CHEMBL4641822 IC50 3.1 nM
O=C(Nc1c(F)c(F)c(-c2ccccc2)c(F)c1F)c1c(O)nn2c(Cl)cccc12 CHEMBL5075870 IC50 3.4 nM
Cc1cc(C(=O)O)c2nc(-c3c(F)c(F)c(-c4ccccc4F)c(F)c3F)[nH]c2c1 CHEMBL3639766 IC50 3.5 nM
Cc1ccccc1-n1ncc2c1CCCC2NC(=O)c1noc2c1CCCC2 CHEMBL4644761 IC50 3.5 nM
CCN(CC(F)F)C(=O)Nc1nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(F)cccc2Cl)cc1F CHEMBL5428012 IC50 3.5 nM
C[C@H](Oc1cc(NC(=O)N2CCCC2CO)c(F)cc1C(=O)Nc1c(F)cccc1Cl)C(F)(F)F CHEMBL5407486 IC50 3.8 nM
Cc1c(-c2ccccc2Cl)cc(F)c(Nc2ncccc2C(=O)O)c1F CHEMBL2263449 pIC50 3.999 nM
O=C(O)c1cc(C2CC2)cnc1Nc1c(F)cc(-c2cccc(OC(F)(F)F)c2)cc1F CHEMBL2263646 pIC50 3.999 nM
O=C(NCc1ccccc1)c1cc(C(=O)Nc2ccccc2)n(-c2ccc(Cl)cc2)n1 CHEMBL143628 Ki 4.0 nM
O=C(NCc1cccnc1)c1cc(C(=O)Nc2ccccc2)n(-c2ccc(Cl)cc2)n1 CHEMBL341925 Ki 4.0 nM
O=C(O)C1=C(C(=O)Nc2c(F)c(F)c(-c3cccc(OC(F)(F)F)c3)c(F)c2F)CSC1 CHEMBL194955 IC50 4.0 nM
O=C(O)c1cc(C2CC2)ccc1Nc1ccc(-c2ccccc2Cl)nc1 CHEMBL3674663 IC50 4.0 nM
C[C@H](Oc1cc(NC(=O)N(C)C)c(F)cc1C(=O)Nc1c(F)cccc1Cl)C(F)(F)F CHEMBL5405721 IC50 4.0 nM
CCCOc1cccc(-c2c(F)c(F)c(NC(=O)c3c(O)nn4ccccc34)c(F)c2F)c1 CHEMBL5090281 IC50 4.09 nM
COc1cc(-n2nnc3c2C(=O)c2ccccc2C3=O)ccc1-c1ccccc1 CHEMBL4633521 IC50 4.1 nM
CCN(CCO)C(=O)Nc1nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(F)cccc2Cl)cc1F CHEMBL5398296 IC50 4.1 nM
O=C(O)c1[nH]c(=O)[nH]c(=O)c1CCc1cc2ccccc2c2ccccc12 CHEMBL3966747 IC50 4.14 nM
CCONC(=O)c1c(C)c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc12 CHEMBL4797708 IC50 4.2 nM
Cc1cccc2c(C(=O)Nc3c(F)c(F)c(-c4ccccc4)c(F)c3F)c(O)nn12 CHEMBL4165923 IC50 4.3 nM
Cc1c(-n2ccc3c(-c4ccccc4)cccc32)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL50499 Ki 4.5 nM
O=C1c2ccccc2C(=O)c2c1nnn2-c1ccc(-c2ccccc2F)cc1 CHEMBL4638432 IC50 4.5 nM
O=C1c2ccccc2C(=O)c2c1nnn2-c1cc(F)c(-c2ccccc2F)c(F)c1 CHEMBL4646288 IC50 4.5 nM
COC(=O)Cc1cccc(-c2c(F)cc(-n3nnc4c3C(=O)c3ccccc3C4=O)cc2F)c1 CHEMBL4633498 IC50 4.6 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3cnccc3Cl)cc2F)c1=O CHEMBL5193091 IC50 4.7 nM
O=C(O)c1c(O)c(-c2ccc(-c3ccccc3)cc2)nc2ccc(F)cc12 CHEMBL41719 IC50 5.0 nM
O=C(O)c1cc(C2CC2)cnc1Nc1c(F)cc(-c2ccccc2Cl)cc1F CHEMBL2263447 pIC50 5.0 nM
Cc1c(-c2ccccc2)cc(F)c(Nc2ncccc2C(=O)O)c1F CHEMBL2263644 pIC50 5.0 nM
Cc1cc(Nc2ccc(C3CC3)cc2C(=O)O)cnc1-c1cccc(OC(F)(F)F)c1 CHEMBL3674655 IC50 5.0 nM
Cc1ccc(Nc2cnc(-c3ccccc3F)c(C)c2)c(C(=O)O)c1 CHEMBL3674658 IC50 5.0 nM
OC1c2ccccc2C(O)c2c1nnn2-c1cc(F)c(-c2ccccc2F)c(F)c1 CHEMBL4639751 IC50 5.1 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3ncccc3Cl)cc2F)c1=O CHEMBL5178023 IC50 5.2 nM
C[C@H](Oc1cc(NC(=O)N2C(=O)CCC2CO)c(F)cc1C(=O)Nc1c(F)cccc1Cl)C(F)(F)F CHEMBL5432814 IC50 5.4 nM
Cc1cc(C(=O)O)c2[nH]c(-c3c(F)c(F)c(-n4c(C)ccc4C)c(F)c3F)nc2c1 CHEMBL3677767 IC50 5.6 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(Cl)cccc2Cl)cc1F CHEMBL5093505 IC50 5.7 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3cc(C)cnc3Cl)cc2F)c1=O CHEMBL5170313 IC50 5.7 nM
Cc1ccc(CCc2c(C(=O)O)[nH]c(=O)[nH]c2=O)cc1 CHEMBL3901542 IC50 5.77 nM
O=C(Nc1c(F)c(F)c(-c2ccccc2)c(F)c1F)c1c(O)nn2c1CCCC2 CHEMBL5087682 IC50 5.8 nM
Cc1c(-c2cccc(OC(F)(F)F)c2)cc(F)c(Nc2ncccc2C(=O)O)c1F CHEMBL2263448 pIC50 5.998 nM
O=C(O)c1cc(C2CC2)cnc1Nc1c(F)cc(-c2cccc(OC3CC3)c2)cc1F CHEMBL2263645 pIC50 5.998 nM
NC(=O)c1ccc(NC(=O)c2cc(C(=O)NCc3ccccc3)nn2-c2ccc(Cl)cc2)cc1 CHEMBL342220 Ki 6.0 nM
O=C(O)c1c(O)c(-c2ccc(Oc3ccccc3)cc2)nc2ccc(F)cc12 CHEMBL218084 IC50 6.0 nM
O=C(O)c1c(O)c(-c2ccc(-c3ccc(O)cc3)cc2)nc2ccccc12 CHEMBL218062 IC50 6.0 nM
Cc1cc(Nc2ccc(C3CC3)cc2C(=O)O)cnc1-c1ccccc1 CHEMBL3674656 IC50 6.0 nM
C[C@H](Oc1cc(NC(=O)N2CCC2CO)c(F)cc1C(=O)Nc1c(F)cccc1Cl)C(F)(F)F CHEMBL5421552 IC50 6.0 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3ccccc3F)cc2F)c1=O CHEMBL5181951 IC50 6.1 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(Cl)cccc2Br)cc1F CHEMBL5091526 IC50 6.2 nM
O=C(Nc1c(F)c(F)c(-c2cccnc2)c(F)c1F)c1c(O)nn2ccccc12 CHEMBL5079607 IC50 6.23 nM
O=C(N[C@@H]1CCCc2c1cnn2-c1ccccc1F)c1ncc2ccccn12 CHEMBL4640411 IC50 6.3 nM
O=C(Nc1c(F)c(F)c(-c2cccc(C(F)(F)F)c2)c(F)c1F)c1c(O)nn2ccccc12 CHEMBL5078949 IC50 6.34 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1ccc2ccccc2c1 CHEMBL5206463 IC50 6.6 nM
Cc1cc(C(=O)O)c2nc(-c3c(F)c(F)c(-c4ccccc4)c(F)c3F)[nH]c2c1 CHEMBL3677748 IC50 6.8 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(F)cccc2Br)cc1F CHEMBL5086708 IC50 6.8 nM
O=C1c2ccccc2C(=O)c2c1nnn2-c1cc(F)c(-c2ccc(F)cc2)c(F)c1 CHEMBL4632909 IC50 6.9 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(F)cccc2Cl)cc1F CHEMBL5076703 IC50 6.9 nM
O=C(O)C1=C(C(=O)Nc2c(F)c(F)c(-c3cccc(OC(F)(F)F)c3)c(F)c2F)CCC1 CHEMBL154623 IC50 7.0 nM
O=C(O)c1c(O)c(-c2ccc(-c3ccc(O)cc3)cc2)nc2ccc(F)cc12 CHEMBL386159 IC50 7.0 nM
O=C(O)c1c(O)c(-c2ccc(Oc3ccccc3)cc2)nc2ccccc12 CHEMBL218169 IC50 7.0 nM
Cc1c(-c2ccc(-c3ccccc3)cc2)nc2ccc(F)cc2c1C(=O)O CHEMBL220467 IC50 7.0 nM
N#C/C(C(=O)Nc1ccc(-c2ccccc2)cc1)=C(/O)C1CC1 CHEMBL142996 Ki(app) 7.0 nM
COc1cccc(-c2ncc(Nc3ccc(C4CC4)cc3C(=O)O)cc2C(F)(F)F)c1 CHEMBL3674661 IC50 7.0 nM
Cc1ccccc1-n1ncc2c1CCC[C@H]2NC(=O)c1onc2c1CCCC2 CHEMBL4644297 IC50 7.0 nM
Cc1cc(NC(=O)c2c(O)nn3ccccc23)c(C(C)C)cc1Oc1ccccc1 CHEMBL5192490 IC50 7.2 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(Br)cccc2Br)cc1F CHEMBL5083197 IC50 7.3 nM
Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc2c1C(=O)N(C)O CHEMBL4759152 IC50 7.7 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1cccc(C(F)(F)F)c1 CHEMBL5193565 IC50 7.9 nM
O=C(O)c1cc(Cl)cnc1Nc1c(F)cc(-c2ccccc2)cc1F CHEMBL2259675 pIC50 7.998 nM
COc1ccccc1-c1c(F)c(F)c(NC(=O)C2=C(C(=O)O)CCC2)c(F)c1F CHEMBL345701 IC50 8.0 nM
O=C(NCc1cccnc1)c1cc(C(=O)Nc2ccc(N3CCCCC3)cc2)n(-c2ccc(Cl)cc2)n1 CHEMBL142444 Ki 8.0 nM
Cc1c(-c2ccc(-c3ccccc3)cc2)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL288708 Ki 8.0 nM
CN(/N=C/c1ccccc1C(=O)O)c1nc(-c2ccccc2Cl)cs1 CHEMBL3980486 IC50 8.0 nM
Cc1ccc(/C=N/N(C)c2nc(-c3ccccc3Cl)cs2)c(C(=O)O)c1 CHEMBL3922925 IC50 8.0 nM
Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL300058 IC50 8.0 nM
O=C(O)c1cc(C2CC2)ccc1Nc1ccc(-c2ccccc2F)nc1 CHEMBL3674675 IC50 8.0 nM
CCn1c(CO)nn(-c2cc(OC(C)C(F)(F)F)c3c(Nc4c(F)cccc4Cl)nn(C)c3c2)c1=O CHEMBL5181160 IC50 8.0 nM
O=C([O-])c1c2c(nc3ccc(F)cc13)-c1ccc(-c3ccccc3)cc1CC2 CHEMBL104209 Ki 8.3 nM
Cc1c(-c2ccc(-c3ccccc3)cc2)nc2ccc(C(F)(F)F)cc2c1C(=O)O CHEMBL38692 Ki 8.4 nM
Cc1cc(C(=O)O)c2[nH]c(-c3c(F)c(F)c(-c4cccc(F)c4)c(F)c3F)nc2c1 CHEMBL3677811 IC50 8.86 nM
CCOc1ccccc1-c1cc(F)c(NC(=O)c2ccsc2C(=O)O)c(F)c1 CHEMBL200856 IC50 9.0 nM
CCCN(/N=C/c1ccccc1C(=O)O)c1nc(-c2ccccc2Cl)cs1 CHEMBL3909259 IC50 9.0 nM
Cc1ccc(Nc2cnc(-c3cccc(C(=O)N4CCCC4)c3)c(C)c2)c(C(=O)O)c1 CHEMBL3674668 IC50 9.0 nM
O=C(O)c1cc(C2CC2)ccc1Nc1cnc(-c2ccccc2C(F)(F)F)nc1 CHEMBL3674671 IC50 9.0 nM
O=C(N[C@@H]1CCCc2c1cnn2-c1ccccc1F)c1noc2c1CCCC2 CHEMBL4644015 IC50 9.0 nM
COc1cccc(-c2c(F)cc(-n3nnc4c3C(=O)c3ccccc3C4=O)cc2F)c1 CHEMBL4648164 IC50 9.0 nM
O=C(O)c1cc(C2CC2)cnc1Nc1ccc2c(ccn2-c2ccccc2)c1 CHEMBL5182587 IC50 9.0 nM
C[C@H](Oc1cc(NC(=O)N2CCC(F)(F)C2)c(F)cc1C(=O)Nc1c(F)cccc1Cl)C(F)(F)F CHEMBL5427450 IC50 9.0 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1cccc(OC)c1 CHEMBL5209435 IC50 9.2 nM
CCC(C)c1ccc(-c2nc3ccc(Br)cc3c(C(=O)O)c2C)cc1 CHEMBL3818031 IC50 9.7 nM
Cc1c(-c2ccc(-c3cccnc3Cl)cc2)nc2ccc(F)cc2c1C(=O)O CHEMBL4228712 IC50 9.71 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1cccc2ccccc12 CHEMBL5182494 IC50 9.8 nM
Cc1ccccc1-c1ccc2c(c1)CCc1c-2nc2ccc(F)cc2c1C(=O)[O-] CHEMBL321060 Ki 10.0 nM
O=C(O)c1cc(-c2ccc(-c3ccccc3)cc2)nc2ccc(F)cc12 CHEMBL39162 Ki 10.0 nM
Cc1ccc2nc(-c3ccc(-c4ccccc4)cc3)c(C)c(C(=O)O)c2c1 CHEMBL290910 Ki 10.0 nM
O=C(O)c1cscc1C(=O)Nc1c(F)cc(-c2ccccc2OC(F)(F)F)cc1F CHEMBL199347 IC50 10.0 nM
CCOc1ccccc1-c1cc(F)c(NC(=O)c2cscc2C(=O)O)c(F)c1 CHEMBL383165 IC50 10.0 nM
O=C(O)c1c(O)c(-c2ccc(-c3ccccc3)cc2)nc2ccccc12 CHEMBL219648 IC50 10.0 nM
O=C(O)c1cc(C2CC2)ccc1Nc1cnc(-c2ccccc2)c(-c2ccccc2)c1 CHEMBL3674633 IC50 10.0 nM
Cc1ccc(Nc2cnc(-c3cccc(Cl)c3)c(C)c2)c(C(=O)O)c1 CHEMBL3674657 IC50 10.0 nM
O=C(O)c1cc(C2CC2)ccc1Nc1cnc(-c2ccccc2F)nc1 CHEMBL3674670 IC50 10.0 nM
Cc1nc2c(C(=O)O)cc(-c3ccc(-c4ccccc4)cc3)cc2[nH]1 CHEMBL4757605 IC50 10.0 nM
Cc1nc2c(C(=O)O)cc(-c3ccc(-c4ccc(O)cc4)cc3)cc2[nH]1 CHEMBL4796278 IC50 10.0 nM
Cc1nc2c(C(=O)O)cc(-c3c(F)c(F)c(-c4ccc(CN5CCOCC5)cc4)c(F)c3F)cc2[nH]1 CHEMBL4796123 IC50 10.0 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3cc(OC)ncc3C)cc2F)c1=O CHEMBL5201357 IC50 10.0 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(OC(C)C)c(-c2cccc(C(F)(F)F)c2)cc1F CHEMBL5169436 IC50 10.2 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1cccc(OC(F)(F)F)c1 CHEMBL5203955 IC50 10.9 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)c2ccccc2Cl)cc1F CHEMBL5427364 IC50 10.9 nM
Cc1ccccc1-c1cc(F)c(Nc2ncccc2C(=O)O)c(F)c1 CHEMBL2263626 pIC50 10.99 nM
Cc1c(-c2ccc(-c3ccc(O)cc3F)cc2)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL43639 Ki 11.0 nM
COc1cccc(-c2cc(F)c(NC(=O)C3=C(C(=O)O)CCC3)c(F)c2)c1 CHEMBL195622 IC50 11.0 nM
O=C(O)C1=C(C(=O)Nc2ccc(OCc3c(F)cccc3Cl)c(Cl)c2)CCC1 CHEMBL193365 IC50 11.0 nM
C/C(O)=C(\C#N)C(=O)Nc1ccc(-c2ccccc2)cc1 CHEMBL519160 Ki(app) 11.0 nM
CN(/N=C/c1ccccc1C(=O)O)c1nc(-c2cccc(Cl)c2)cs1 CHEMBL3913950 IC50 11.0 nM
Cc1ccc(Nc2cnc(-c3cccc(OC(C)C)c3)c(C)c2)c(C(=O)O)c1 CHEMBL3674648 IC50 11.0 nM
Cc1ccc(F)c(-n2ncc3c2CCC[C@H]3NC(=O)c2onc3c2CCCC3)c1 CHEMBL4648871 IC50 11.0 nM
O=C(N[C@@H]1CCCc2c1cnn2-c1ccccc1F)c1onc2c1CCCC2 CHEMBL4649285 IC50 11.0 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3ccnc(OC)c3Cl)cc2F)c1=O CHEMBL5197655 IC50 11.0 nM
O=C(O)c1[nH]c(=O)[nH]c(=O)c1CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL3926030 IC50 11.4 nM
Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2cnc(C(F)(F)F)cc2c1C(=O)O CHEMBL4227747 IC50 11.8 nM
CCc1cnc(Nc2c(F)cc(-c3cccc(OC)c3)cc2F)c(C(=O)O)c1 CHEMBL2263640 pIC50 11.99 nM
COc1cccc(-c2cc(F)c(Nc3ncc(C)cc3C(=O)O)c(F)c2)c1 CHEMBL2263638 pIC50 11.99 nM
COc1ccc(-n2nc(C(=O)NCc3cccnc3)cc2C(=O)Nc2ccccc2)cc1 CHEMBL143552 Ki 12.0 nM
COc1ccccc1-c1ccc(NC(=O)c2ccsc2C(=O)O)cc1Cl CHEMBL200858 IC50 12.0 nM
Nc1c(-c2ccc(-c3ccccc3)cc2)nc2ccc(F)cc2c1C(=O)O CHEMBL218249 IC50 12.0 nM
COc1cccc(-c2ncc(Nc3ccc(C)cc3C(=O)O)cc2C(F)(F)F)c1 CHEMBL3674652 IC50 12.0 nM
Cc1ccc(Nc2cnc(-c3cccc(C(=O)NC4CC4)c3)c(C)c2)c(C(=O)O)c1 CHEMBL3674669 IC50 12.0 nM
Cc1ccccc1-c1ncc(Nc2ccc(C3CC3)cc2C(=O)O)cn1 CHEMBL3674672 IC50 12.0 nM
Cc1cccc(-n2ncc3c2CCCC3NC(=O)c2noc3c2CCCC3)c1 CHEMBL4635891 IC50 12.0 nM
Cc1c(Cc2ccccc2F)c(OC(C)C)nn1-c1ncc(C2CC2)cn1 CHEMBL3409286 pIC50 12.59 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1cc2ccccc2o1 CHEMBL5200075 IC50 12.9 nM
Cc1ccc(-c2ccc3c(c2)SCc2c-3nc3ccc(F)cc3c2C(=O)[O-])cc1 CHEMBL106467 Ki 13.0 nM
CSc1c(-c2ccc(-c3ccccc3)cc2)nc2ccc(F)cc2c1C(=O)O CHEMBL39472 Ki 13.0 nM
COc1c(-c2ccc(-c3ccccc3)cc2)nc2ccc(F)cc2c1C(=O)O CHEMBL40093 Ki 13.0 nM
CCc1cc(O)n2nc(SCc3cc(Cl)ccc3Cl)nc2n1 CHEMBL2177861 IC50 13.0 nM
CC(=O)Nc1ccc(COc2ccc(-c3ccc(-c4nc5c(C(=O)O)cc(C)cc5[nH]4)cc3)cc2)cc1 CHEMBL3593806 IC50 13.0 nM
Brc1ccc2[nH]c3c(c2c1)CCCC3n1cccc1 CHEMBL5279134 EC50 13.0 nM
CCCC(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(F)cccc2Cl)cc1F CHEMBL5399532 IC50 13.0 nM
[2H]C([2H])([2H])Oc1cccc(-c2cc(F)c(NC(=O)C3=C(C(=O)O)CC(F)(F)C3)c(F)c2)c1 CHEMBL5408943 IC50 13.0 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(OC(C)C)c(C(=O)Nc2c(Cl)cccc2Cl)cc1F CHEMBL5076991 IC50 13.1 nM
COc1ccc2ccc(CCc3c(C(=O)O)[nH]c(=O)[nH]c3=O)cc2c1 CHEMBL3962745 IC50 13.3 nM
Cc1cc(C(=O)O)c2[nH]c(-c3c(F)c(F)c(-c4cccc(O)c4)c(F)c3F)nc2c1 CHEMBL3677789 IC50 13.5 nM
Cc1cc(C(=O)O)c2[nH]c(-c3c(F)c(F)c(-c4cccc(OCc5ccccc5)c4)c(F)c3F)nc2c1 CHEMBL3677790 IC50 13.6 nM
COc1cccc(-c2cc(F)c(NC(=O)/C(C#N)=C(/C)O)cc2OC(C)C)c1 CHEMBL5186273 IC50 13.9 nM
N#C/C(C(=O)Nc1ccc(C(F)(F)F)cc1)=C(/O)C1CC1 CHEMBL141732 Ki(app) 14.0 nM
COc1cccc(-c2ccc(Nc3cnccc3C(=O)[O-])c(OC(F)(F)F)c2)c1 CHEMBL2263634 pIC50 14.0 nM
Cc1ccc(/C=N/N(C)c2nc(-c3ccccc3)c(C)s2)c(C(=O)O)c1 CHEMBL3931872 IC50 14.0 nM
Cc1ccc(Nc2cnc(-c3ccccc3Cl)c(C)c2)c(C(=O)O)c1 CHEMBL3674649 IC50 14.0 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3ccc(C)nc3Cl)cc2F)c1=O CHEMBL5184263 IC50 14.0 nM
CCCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1cccc(OC)c1 CHEMBL5198888 IC50 14.4 nM
Cc1c(N2CCc3c(-c4ccccc4)cccc32)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL51082 Ki 15.0 nM
O=C(O)C1=C(C(=O)Nc2c(F)cc(-c3cccc(OC(F)(F)F)c3)cc2F)CSC1 CHEMBL194075 IC50 15.0 nM
COc1cccc(-c2cc(F)c(Nc3ncccc3C(=O)O)c(F)c2)c1 CHEMBL2263632 pIC50 15.0 nM
CCCC(C)N(/N=C/c1ccccc1C(=O)O)c1nc(-c2ccccc2Cl)c(C)s1 CHEMBL3893343 IC50 15.0 nM
O=C(N[C@@H]1CCCc2c1cnn2-c1ccccc1F)c1cc(C(F)(F)F)ccn1 CHEMBL4642109 IC50 15.0 nM
Cc1c(C(O)c2ccccc2)c(OC(C)C)nn1-c1ncc(C2CC2)cn1 CHEMBL3409299 pIC50 15.85 nM
CCOc1cccc(-c2cc(F)c(NC(=O)c3cocc3C(=O)O)c(F)c2)c1 CHEMBL200895 IC50 16.0 nM
C/C(O)=C(\C#N)C(=O)Nc1ccc(-c2ccccc2Cl)cc1 CHEMBL484531 Ki(app) 16.0 nM
CCOc1cccc(-c2ccc(NC(=O)/C(C#N)=C(/C)O)cc2)c1 CHEMBL483995 Ki(app) 16.0 nM
Cc1cc(-c2cc(C(=O)O)c3cc(F)ccc3n2)cc(C)c1Oc1ccccc1 CHEMBL2385511 IC50 16.0 nM
Cc1cc(C(=O)O)c2[nH]c(-c3c(F)c(F)c(-c4ccc(O)cc4)c(F)c3F)nc2c1 CHEMBL3677781 IC50 16.0 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(F)cccc2F)cc1F CHEMBL5079947 IC50 16.0 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(F)cnc(OC)c3C#N)cc2F)c1=O CHEMBL5209156 IC50 16.0 nM
CCC(CC)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1cccc(OC)c1 CHEMBL5194645 IC50 16.4 nM
O=C(O)c1[nH]c(=O)[nH]c(=O)c1CCc1ccc(Oc2ccccc2)cc1 CHEMBL3943890 IC50 16.6 nM
CC(C)(C)c1ccc(CCc2c(C(=O)O)[nH]c(=O)[nH]c2=O)cc1 CHEMBL3892598 IC50 16.8 nM
CCOc1cccc(-c2cc(F)c(NC(=O)C3=C(C(=O)O)CCC3)c(F)c2)c1 CHEMBL351786 IC50 17.0 nM
O=C([O-])c1c2c(nc3ccc(F)cc13)-c1ccc(-c3ccccc3)cc1SC2 CHEMBL104302 Ki 17.0 nM
O=C(O)c1c2c(nc3ccc(F)cc13)-c1ccc(-c3ccccc3)cc1CC2 CHEMBL289470 Ki 17.0 nM
O=C(O)c1cccnc1Nc1c(F)cc(-c2cccc(OC3CC3)c2)cc1F CHEMBL2263643 IC50 17.0 nM
Cc1ccnc(C(=O)N[C@@H]2CCCc3c2cnn3-c2ccccc2C)c1 CHEMBL4636500 IC50 17.0 nM
CCOc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1C(=O)Nc1c(Cl)cccc1Cl CHEMBL5080473 IC50 17.4 nM
O=C(Nc1c(F)c(F)c(-c2ccc(F)cc2)c(F)c1F)c1c(O)nn2ccccc12 CHEMBL5071607 IC50 17.7 nM
O=C(O)C1=C(C(=O)Nc2c(F)cc(-c3ccccc3Cl)cc2F)CCC1 CHEMBL345147 IC50 18.0 nM
O=C(O)c1c(O)c(-c2ccc(Sc3ccccc3)cc2)nc2ccc(F)cc12 CHEMBL218085 IC50 18.0 nM
CCOC(=O)c1sc(Nc2ccc3c(c2)CCCC3)nc1-c1ccccc1 CHEMBL3410609 IC50 18.0 nM
Cc1ccc(Nc2cnc(-c3ccccc3)c(F)c2)c(C(=O)O)c1 CHEMBL3674629 IC50 18.0 nM
O=C(O)c1cccc2[nH]c(-c3c(F)c(F)c(-c4ccccc4F)c(F)c3F)nc12 CHEMBL3677816 IC50 18.0 nM
Cc1cc(NC(=O)c2c(O)nn3ccccc23)c(C(C)C)cc1Oc1ccc(C(F)(F)F)cc1 CHEMBL5196292 IC50 18.0 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(OC(C)C)c(C(=O)Nc2c(F)cccc2Br)cc1F CHEMBL5075388 IC50 18.2 nM
CC(C)(C)c1ccc(Oc2ccc(-c3cc(C(=O)O)c4cc(F)ccc4n3)cc2)cc1 CHEMBL2385510 IC50 19.0 nM
CCCC(C)N(/N=C/c1ccccc1C(=O)O)c1nc(-c2ccccc2Cl)cs1 CHEMBL3927131 IC50 19.0 nM
CCOc1ccc(F)c(-c2ccc(Nc3ccc(C)cc3C(=O)O)cn2)c1 CHEMBL3674644 IC50 19.0 nM
Cc1ccc(Nc2ccc(-c3c(F)cccc3F)nc2)c(C(=O)O)c1 CHEMBL3674665 IC50 19.0 nM
CCOc1cccc(-c2cc(F)c(Nc3ncccc3C(=O)O)c(F)c2)c1 CHEMBL2263631 IC50 19.0 nM
CCOc1cccc(-c2ccc(Nc3cnccc3C(=O)[O-])c(F)c2)c1 CHEMBL2263633 IC50 19.0 nM
O=C(NC1CCCc2c1cnn2-c1ccccc1)c1noc2c1CCCC2 CHEMBL4633419 IC50 19.0 nM
O=C1c2ccccc2C(=O)c2c1nnn2-c1ccc(-c2ccccc2)cc1 CHEMBL4640115 IC50 19.0 nM
O=C(O)C1=C(C(=O)Nc2ccc(-c3cccc(OC(F)(F)F)c3)c(Cl)c2)CCC1 CHEMBL345464 IC50 20.0 nM
COc1ccccc1-c1ccc2c(c1)CCc1c-2nc2ccc(F)cc2c1C(=O)[O-] CHEMBL106515 Ki 20.0 nM
Cc1c(-c2ccc(-c3ccccc3)cc2)nc2ccc(Cl)cc2c1C(=O)O CHEMBL38986 Ki 20.0 nM
Cc1ccc(Nc2cnc(-c3ccccc3C(F)(F)F)c(C)c2)c(C(=O)O)c1 CHEMBL3639735 IC50 20.0 nM
O=C(O)c1cccc2[nH]c(-c3c(F)c(F)c(-c4cc(F)cc(F)c4)c(F)c3F)nc12 CHEMBL3677814 IC50 20.0 nM
Nc1ccccc1-c1ccc(-n2nnc3c2C(=O)c2ccccc2C3=O)cc1 CHEMBL4640238 IC50 20.0 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1cccc(Cl)c1 CHEMBL5174428 IC50 20.1 nM
COc1ccc2c(CCc3c(C(=O)O)[nH]c(=O)[nH]c3=O)cccc2c1 CHEMBL3973700 IC50 20.3 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1ccnc(F)c1 CHEMBL5191795 IC50 20.3 nM
COc1cccc2cc(CCc3c(C(=O)O)[nH]c(=O)[nH]c3=O)ccc12 CHEMBL3914213 IC50 20.6 nM
Cc1c(Oc2cccc(-c3ccccc3)c2)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL49129 Ki 21.0 nM
C/C(O)=C(\C#N)C(=O)Nc1ccc(-c2ccccc2Cl)cc1C(F)(F)F CHEMBL520306 Ki(app) 21.0 nM
COc1cccc(-c2ncc(Nc3ccc(C)cc3C(=O)O)cc2C)c1 CHEMBL3674643 IC50 21.0 nM
O=C(O)c1cc(C2CC2)ccc1Nc1cnc(-c2cc(C(F)(F)F)ccc2F)nc1 CHEMBL3674674 IC50 21.0 nM
Cc1cc(C(=O)O)c2nc(-c3c(F)c(F)c(-c4cc(F)cc(F)c4)c(F)c3F)[nH]c2c1 CHEMBL3677830 IC50 21.0 nM
Cc1cnc(C(=O)N[C@@H]2CCCc3c2cnn3-c2ccccc2F)cc1C CHEMBL4648037 IC50 21.0 nM
O=C1c2ccccc2C(=O)c2c1nnn2-c1ccc(-c2cccc(O)c2)cc1 CHEMBL4641558 IC50 21.0 nM
Cc1c(-c2ccc(-c3ccccc3)cc2)nc2cnc(C(F)(F)F)cc2c1C(=O)O CHEMBL4227217 IC50 21.2 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1ccccc1Cl CHEMBL5177094 IC50 21.8 nM
COc1cc(-c2ccccc2)c2c(c1)N(c1nc3ccc(F)cc3c(C(=O)[O-])c1C)CC2 CHEMBL48531 Ki 22.0 nM
C/C(O)=C(\C#N)C(=O)Nc1ccc(-c2ccccc2Cl)cc1Cl CHEMBL483552 Ki(app) 22.0 nM
CCn1c(CO)nn(-c2nc(OC3CC(F)(F)C3(F)F)c(C(=O)Nc3c(F)cccc3Cl)cc2F)c1=O CHEMBL5193667 IC50 22.0 nM
[2H]C([2H])([2H])Oc1cccc(-c2cc(F)c(NC(=O)C3=C(C(=O)O)CSC3)c(F)c2)c1 CHEMBL5396308 IC50 22.0 nM
Cc1ncccc1-c1ccc(-c2cc(C(=O)O)c3ccccc3n2)cc1 CHEMBL4226472 IC50 22.1 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1cccc(Cl)c1C CHEMBL5201005 IC50 22.2 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(OC(C)C)c(C(=O)Nc2c(F)cccc2Cl)cc1F CHEMBL5091721 IC50 22.4 nM
COc1cccc2ccc(CCc3c(C(=O)O)[nH]c(=O)[nH]c3=O)cc12 CHEMBL3964957 IC50 22.5 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1cc(F)cc(F)c1 CHEMBL5173982 IC50 22.6 nM
Cc1c(-c2cn(C)c3c(-c4cccc(C(F)(F)F)c4)cccc23)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL49089 Ki 23.0 nM
C/C(O)=C(\C#N)C(=O)Nc1ccc(-c2cccc(Cl)c2)c(Cl)c1 CHEMBL520008 Ki(app) 23.0 nM
CCOc1cccc(-c2cc(F)c(Nc3ncc(C4CC4)cc3C(=O)O)cc2F)c1 CHEMBL2263641 IC50 23.0 nM
Cc1ccnc(C(=O)N[C@@H]2CCCc3c2cnn3-c2cc(C)ccc2F)c1 CHEMBL4643954 IC50 23.0 nM
CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3ccncc3Cl)cc2F)c1=O CHEMBL5175690 IC50 23.0 nM
COC(=O)c1cccc2cc(CCCCc3c(C(=O)O)[nH]c(=O)[nH]c3=O)ccc12 CHEMBL3955099 IC50 23.9 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)c2ccccc2F)cc1F CHEMBL5416733 IC50 23.9 nM
Cc1ccc(-c2ccc(-c3nc4ccc(F)cc4c(C(=O)[O-])c3C)cc2)cc1 CHEMBL38421 Ki 24.0 nM
Cc1c(N2CCc3c(-c4ccccc4F)cccc32)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL49697 Ki 24.0 nM
Cc1c(N2CCc3c(-c4cccc(C(F)(F)F)c4)cccc32)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL49913 Ki 24.0 nM
CCC(C)N(/N=C/c1ccccc1C(=O)O)c1nc(-c2ccccc2Cl)cs1 CHEMBL3928205 IC50 24.0 nM
Cc1ccccc1-c1ccc2c(c1)CSc1c-2nc2ccc(F)cc2c1C(=O)[O-] CHEMBL104146 Ki 25.0 nM
COc1cccc(-c2ccc3c(c2)CCc2c-3nc3ccc(F)cc3c2C(=O)[O-])c1 CHEMBL107209 Ki 25.0 nM
Cc1c(-c2ccc(-c3ccccc3)cc2)nc2cccc(Cl)c2c1C(=O)O CHEMBL40846 Ki 25.0 nM
Cc1ccccc1-c1cccc2c1CCN2c1nc2ccc(F)cc2c(C(=O)[O-])c1C CHEMBL48244 Ki 25.0 nM
COc1ccccc1-c1ccc(NC(=O)/C(C#N)=C(/C)O)c(Cl)c1 CHEMBL483161 Ki(app) 25.0 nM
C/C(O)=C(\C#N)C(=O)Nc1ccc(-c2cccc(Cl)c2Cl)cc1 CHEMBL505315 Ki(app) 25.0 nM
Nc1ccc(-c2ccc(-n3nnc4c3C(=O)c3ccccc3C4=O)cc2)cc1 CHEMBL4635090 IC50 25.0 nM
COc1ccc(-n2nc(C(=O)NCc3ccccc3)cc2C(=O)Nc2ccc(C(=O)N3CCCC3)cc2)cc1 CHEMBL359171 Ki 26.0 nM
Cc1c(-c2cccc3c(-c4ccccc4)cccc23)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL48928 Ki 26.0 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(-c2cccc(OC)c2)c(C(=O)OC)c1 CHEMBL1929450 IC50 26.0 nM
CCOC(=O)c1sc(Nc2ccc3c(c2)CCC3)nc1-c1ccccc1 CHEMBL3410607 IC50 26.0 nM
O=C(O)c1cccc2nc(-c3c(F)c(F)c(-c4cccc(OCc5ccccc5)c4)c(F)c3F)[nH]c12 CHEMBL3677792 IC50 26.0 nM
O=C(N[C@@H]1CCCc2c1cnn2-c1ccccc1F)c1cc(Cl)ccn1 CHEMBL4646131 IC50 26.0 nM
O=C(N[C@@H]1CCCc2c1cnn2-c1ccccc1F)c1cc(Br)ccn1 CHEMBL4643648 IC50 26.0 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1cccc(F)c1C CHEMBL5175230 IC50 26.1 nM
Cc1ccc(-c2ccc(-c3nc4ccc(F)cc4c(C(=O)O)c3C)cc2)c(Cl)n1 CHEMBL4228971 IC50 26.2 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1cccc(F)c1 CHEMBL5182196 IC50 26.8 nM
Cc1ccccc1-c1ccc2c(c1)SCc1c-2nc2ccc(F)cc2c1C(=O)[O-] CHEMBL321163 Ki 27.0 nM
Cc1c(-c2cn(C)c3c(-c4ccccc4)cccc23)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL417722 Ki 27.0 nM
CCOC(=O)/C(C#N)=C\Nc1cccc(-c2ccccc2)c1 CHEMBL387254 Ki 27.0 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(-c2cccc(OC(F)(F)F)c2)c(C(=O)OC)c1 CHEMBL1929439 IC50 27.0 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1ccccc1F CHEMBL5198288 IC50 27.3 nM
Cc1c(-c2ccc(C3CCCCC3)cc2)nc2ccc(F)cc2c1C(=O)O CHEMBL39396 Ki 28.0 nM
CC(=O)Nc1cccc(COc2ccc(-c3ccc(-c4nc5c(C(=O)O)cc(C)cc5[nH]4)cc3)cc2)c1 CHEMBL3593805 IC50 28.0 nM
CN(/N=C/c1ccccc1C(=O)O)c1nc(-c2cc(Cl)ccc2Cl)cs1 CHEMBL3941922 IC50 28.0 nM
O=C(O)c1cc(C2CC2)ccc1Nc1cnc(C2CC2)c(-c2ccccc2)c1 CHEMBL3674635 IC50 28.0 nM
Cc1ccc(Nc2ccc(-c3cc(OC(C)C)ccc3F)nc2)c(C(=O)O)c1 CHEMBL3674647 IC50 28.0 nM
O=C(O)c1cccc2nc(-c3c(F)c(F)c(-c4cccc(F)c4)c(F)c3F)[nH]c12 CHEMBL3677810 IC50 28.2 nM
Cc1c(-c2ccc(-c3ccccc3)cc2)nc2cnccc2c1C(=O)O CHEMBL4227722 IC50 28.3 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1ccc2c(c1)OCO2 CHEMBL5179920 IC50 28.8 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1ccccc1 CHEMBL5171811 IC50 28.9 nM
Cc1c(-c2ccc(Oc3ccccc3)cc2)nc2ccc(F)cc2c1C(=O)O CHEMBL38614 Ki 29.0 nM
CCOC(=O)c1sc(Nc2ccc3ccccc3c2)nc1-c1ccccc1 CHEMBL3410610 IC50 29.0 nM
O=C(O)c1ccccc1/C=N/Nc1nc(-c2ccccc2Cl)cs1 CHEMBL3896992 IC50 29.0 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)c2ccccc2)cc1F CHEMBL5426182 IC50 29.0 nM
COc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1C(=O)Nc1c(F)cccc1Br CHEMBL5077918 IC50 29.5 nM
CCc1c(-c2ccc(-c3ccccc3)cc2)nc2ccc(F)cc2c1C(=O)O CHEMBL36047 Ki 30.0 nM
COc1ccccc1-c1cccc2c1CCN2c1nc2ccc(F)cc2c(C(=O)[O-])c1C CHEMBL49214 Ki 30.0 nM
Cc1c(N2CCc3c(-c4ccccc4)cc(F)cc32)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL51243 Ki 30.0 nM
C/C(O)=C(\C#N)C(=O)Nc1ccc(C(F)(F)F)cc1 CHEMBL973 Ki 30.0 nM
CCOc1cccc(-c2ncc(Nc3ccc(C)cc3C(=O)O)cc2C)c1 CHEMBL3674640 IC50 30.0 nM
CCOC(=O)c1cccc(-n2ncc3c2CCCC3NC(=O)c2noc3c2CCCC3)c1 CHEMBL4639707 IC50 30.0 nM
CCC(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(F)cccc2Cl)cc1F CHEMBL5439442 IC50 30.0 nM
COc1cccc(-c2cc(F)c(NC(=O)/C(C#N)=C(/C)O)cc2OCC(C)C)c1 CHEMBL5183905 IC50 30.1 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1ccc(F)c(F)c1 CHEMBL5181287 IC50 30.4 nM
O=C([O-])c1c2c(nc3ccc(C(F)(F)F)cc13)-c1ccc(-c3ccccc3)cc1CC2 CHEMBL105175 Ki 31.0 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(-c2cccc(Cl)c2)c(C(=O)OC)c1 CHEMBL1929437 IC50 31.0 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(-c2ccc(F)cc2F)c(C(=O)OC)c1 CHEMBL1929441 IC50 31.0 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(-c2cccc(OC3CCC3)c2)c(C(=O)OC)c1 CHEMBL1929453 IC50 31.0 nM
O=C(N[C@@H]1CCCc2c1cnn2-c1ccccc1F)c1cc(F)ccn1 CHEMBL4649747 IC50 31.0 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1ccccc1C CHEMBL5186097 IC50 31.0 nM
COc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1C(=O)Nc1c(F)cccc1Cl CHEMBL5088194 IC50 31.1 nM
COCOc1ccc2ccc(CCc3c(C(=O)O)[nH]c(=O)[nH]c3=O)cc2c1 CHEMBL3936361 IC50 31.5 nM
Cc1ccc(CNC(=O)c2cc(C(=O)Nc3ccccc3)n(-c3ccc(Cl)cc3)n2)cc1 CHEMBL143868 Ki 32.0 nM
COc1cccc(-c2cccc3c(-c4nc5ccc(F)cc5c(C(=O)[O-])c4C)cn(C)c23)c1 CHEMBL297497 Ki 32.0 nM
Cc1ccc(Nc2ccc(-c3ccccc3Cl)nc2)c(C(=O)O)c1 CHEMBL3674654 IC50 32.0 nM
Cc1cc(C(=O)O)c2nc(-c3c(F)c(F)c(-c4cccnc4)c(F)c3F)[nH]c2c1 CHEMBL3677825 IC50 32.0 nM
O=C(NC1CCCc2c1cnn2-c1ccccc1F)c1onc2c1CCCC2 CHEMBL4643928 IC50 32.0 nM
Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc2c1C(=O)NS(C)(=O)=O CHEMBL4762268 IC50 32.0 nM
C/C(=C\c1ccc2ccccc2c1Cl)C(=O)Nc1ccc(F)cc1C(=O)O CHEMBL5206824 IC50 32.0 nM
CCn1c(CO)nn(-c2nc(OC3CCOC3)c(C(=O)Nc3c(F)cccc3Cl)cc2F)c1=O CHEMBL5189556 IC50 32.0 nM
O=C(O)c1cc(-c2ccc(-c3cccnc3Cl)cc2)nc2ccccc12 CHEMBL4224965 IC50 32.7 nM
COc1cccc(-c2ccc(Nc3ncc(C4CC4)cc3C(=O)O)c(F)c2)c1 CHEMBL2263637 pIC50 32.96 nM
O=C(O)C1=C(C(=O)Nc2c(F)cc(-c3cccc(OC(F)(F)F)c3)cc2F)CCC1 CHEMBL157105 IC50 33.0 nM
Cc1ccc(Nc2cnc(-c3cccc(C(=O)N(C)C)c3)c(C)c2)c(C(=O)O)c1 CHEMBL3674653 IC50 33.0 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1ccc(Cl)cc1 CHEMBL5174482 IC50 33.3 nM
O=C([O-])c1c2c(nc3ccc(F)cc13)-c1ccc(-c3ccccc3F)cc1CC2 CHEMBL320204 Ki 34.0 nM
COc1cccc(-c2cccc3c2CCN3c2nc3ccc(F)cc3c(C(=O)[O-])c2C)c1 CHEMBL50279 Ki 34.0 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(-c2cccc(OC(F)F)c2)c(C(=O)OC)c1 CHEMBL1929452 IC50 34.0 nM
Cc1ccnc(C(=O)N[C@@H]2CCCc3c2cnn3-c2ccccc2F)c1 CHEMBL4639649 IC50 34.0 nM
CCCOc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1cccc(OC)c1 CHEMBL5197464 IC50 34.6 nM
CCOC(=O)c1sc(Nc2ccc(C)c(Cl)c2)nc1-c1ccccc1 CHEMBL3410596 IC50 35.0 nM
Cc1ccn2nc(O)c(C(=O)Nc3c(F)c(F)c(-c4ccccc4)c(F)c3F)c2c1 CHEMBL4177202 IC50 35.0 nM
O=C(c1ccccc1)c1cc(F)c(Nc2ncccc2C(=O)O)c(F)c1 CHEMBL5412179 IC50 35.1 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1C(=O)c1ccccc1 CHEMBL5401192 IC50 35.6 nM
O=C(O)c1cc(-c2ccc(Oc3ccccc3)cc2)nc2ccc(F)cc12 CHEMBL2385515 IC50 36.0 nM
Cc1c(-c2ccc(-c3cccnc3Cl)cc2)nc2ccc(Cl)cc2c1C(=O)O CHEMBL4224944 IC50 36.0 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(OC(C)C)c(C(=O)Nc2c(F)cccc2F)cc1F CHEMBL5083113 IC50 36.2 nM
Cc1cccc(-c2ccc3c(c2)SCc2c-3nc3ccc(F)cc3c2C(=O)[O-])c1 CHEMBL104136 Ki 37.0 nM
Cc1ccc(Nc2cnc(-c3ccncc3F)c(C)c2)c(C(=O)O)c1 CHEMBL3674659 IC50 37.0 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(OC(C)C)c(C(=O)c2ccccc2)cc1F CHEMBL5411122 IC50 37.1 nM
C/C(=C\Cc1c(O)c(Cl)c(C)c(C=O)c1O)CC/C=C(\C)[C@@H]1CC(=O)C(C)(C)O1 CHEMBL133046 IC50 37.5 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1ccc(F)cc1 CHEMBL5208193 IC50 37.8 nM
Cc1c(-c2ccc(-c3ccc(Br)cc3)cc2)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL38242 Ki 38.0 nM
O=C(O)c1cc(C2CC2)ccc1Nc1cnc(-c2cc(F)ccc2F)nc1 CHEMBL3674673 IC50 38.0 nM
O=C(O)c1cccc2[nH]c(-c3c(F)c(F)c(-c4ccccc4)c(F)c3F)nc12 CHEMBL3677738 IC50 38.0 nM
C/C(O)=C(\C#N)C(=O)Nc1ccc(-c2ccccc2)cc1Cl CHEMBL483994 Ki(app) 39.0 nM
COc1cc2ccccc2cc1CCc1c(C(=O)O)[nH]c(=O)[nH]c1=O CHEMBL3935254 IC50 39.8 nM
CCC(C)Oc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1ccc(OC)cc1 CHEMBL5177668 IC50 39.8 nM
O=C([O-])c1c2c(nc3ccc(F)cc13)-c1ccc(-c3ccccc3C(F)(F)F)cc1CC2 CHEMBL322274 Ki 40.0 nM
Cc1ccc(-c2ccc3c(c2)CCc2c-3nc3ccc(F)cc3c2C(=O)[O-])cc1 CHEMBL106865 Ki 40.0 nM
Cc1c(-c2ccc(C(C)(C)C)cc2)nc2ccc(F)cc2c1C(=O)O CHEMBL416057 Ki 40.0 nM
COc1ccccc1-c1cccc2c(-c3nc4ccc(F)cc4c(C(=O)[O-])c3C)cn(C)c12 CHEMBL49840 Ki 40.0 nM
C/C(O)=C(\C#N)C(=O)Nc1ccc(-c2cccc(Cl)c2Cl)cc1Cl CHEMBL520999 Ki(app) 40.0 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(-c2cccnc2)c(C(=O)OC)c1 CHEMBL1929442 IC50 40.0 nM
Cc1ccc(F)c(-n2ncc3c2CCC[C@H]3NC(=O)c2cc(C(F)(F)F)ccn2)c1 CHEMBL4639060 IC50 40.0 nM
CCOc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1C(=O)Nc1c(F)cccc1Br CHEMBL5070988 IC50 40.0 nM
C[C@H](Oc1cc(NC(=O)C2CC2)c(F)cc1C(=O)Nc1c(F)cccc1Cl)C(F)(F)F CHEMBL5423878 IC50 40.0 nM
CN(C)C(=O)c1cccc2cc(CCc3c(C(=O)O)[nH]c(=O)[nH]c3=O)ccc12 CHEMBL3928909 IC50 40.4 nM
O=C(O)C1=C(C(=O)Nc2ccc(OCc3c(F)cccc3Cl)c(Cl)c2)COC1 CHEMBL193371 IC50 41.0 nM
Cc1ccc(Nc2cnc(N3CCCCC3)c(C)c2)c(C(=O)O)c1 CHEMBL3674636 IC50 41.0 nM
C/C(=C\c1ccc2ccccc2c1)C(=O)Nc1ccc(F)cc1C(=O)O CHEMBL5193049 IC50 41.0 nM
CCOc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1-c1cccc(OC)c1 CHEMBL5197071 IC50 41.4 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(OC(C)C)c(C(=O)Nc2ccccc2Br)cc1F CHEMBL5094387 IC50 41.5 nM
COc1ccccc1-c1cc(F)c(NC(=O)C2=C(C(=O)O)CCC2)c(F)c1 CHEMBL154121 IC50 42.0 nM
C/C(=C\c1ccc2ccccc2c1Br)C(=O)Nc1ccc(F)cc1C(=O)O CHEMBL5177430 IC50 42.0 nM
O=C([O-])c1c2c(nc3ccc(F)cc13)-c1ccc(-c3cccc(C(F)(F)F)c3)cc1CC2 CHEMBL104824 Ki 43.0 nM
Cc1cc(Oc2ccccc2)c(C)cc1NC(=O)c1c(O)nn2ccccc12 CHEMBL4165815 IC50 43.0 nM
COc1cccc(-c2cc(F)c(NC(=O)/C(C#N)=C(/C)O)cc2OCC2CCCCC2)c1 CHEMBL5191491 IC50 43.1 nM
COc1cccc(-c2ccc(NC(=O)c3ccsc3C(=O)O)c(F)c2)c1 CHEMBL371732 IC50 44.0 nM
C/C(=C\c1ccc2ccccc2c1F)C(=O)Nc1ccc(F)cc1C(=O)O CHEMBL5181885 IC50 44.0 nM
CCOc1cc(NC(=O)/C(C#N)=C(/C)O)c(F)cc1C(=O)Nc1c(F)cccc1Cl CHEMBL5078926 IC50 44.1 nM
COCOc1cc2ccccc2cc1CCc1c(C(=O)O)[nH]c(=O)[nH]c1=O CHEMBL3905364 IC50 44.3 nM
COC(=O)c1cccc2cc(CCc3c(C(=O)O)[nH]c(=O)[nH]c3=O)ccc12 CHEMBL3933268 IC50 44.3 nM
O=C(O)C1=C(C(=O)Nc2c(F)cc(-c3ccccc3F)cc2F)CCC1 CHEMBL154513 IC50 45.0 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(-c2ccc(Cl)cc2)c(C(=O)OC)c1 CHEMBL1929438 IC50 45.0 nM
Cn1nc(O)c(C(=O)Nc2c(F)c(F)c(-c3ccccc3)c(F)c2F)n1 CHEMBL4062046 IC50 45.0 nM
COc1ccc(F)cc1-c1ncc(Nc2ccc(C)cc2C(=O)O)cc1C CHEMBL3674677 IC50 46.0 nM
O=C(O)c1[nH]c(=O)[nH]c(=O)c1CCc1ccc2ccccc2c1 CHEMBL3984245 IC50 46.1 nM
COc1ccc2cc(CCc3c(C(=O)O)[nH]c(=O)[nH]c3=O)ccc2c1 CHEMBL3925700 IC50 46.2 nM
Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc2c1C(N)=O CHEMBL4760819 IC50 47.0 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(OC(C)C)c(C(=O)Nc2ccccc2Cl)cc1F CHEMBL5081283 IC50 47.2 nM
COc1ccc2cc(CCc3c(C(=O)O)[nH]c(=O)[nH]c3=O)c(OC)cc2c1 CHEMBL3945267 IC50 47.8 nM
O=C([O-])c1c2c(nc3ccc(F)cc13)-c1ccc(-c3ccccc3)cc1OC2 CHEMBL107642 Ki 48.0 nM
Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2cnccc2c1C(=O)O CHEMBL39971 Ki 48.0 nM
Cc1cc(C(=O)O)c2nc(-c3c(F)c(F)c(-c4ccc(OCc5ccccc5)cc4)c(F)c3F)[nH]c2c1 CHEMBL3677812 IC50 48.0 nM
COCC1CCCN1C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(F)cccc2Cl)cc1F CHEMBL5403590 IC50 48.0 nM
Cc1ccc(/C=C2\COc3cc4ccccc4cc3C2=O)cc1 CHEMBL5187875 IC50 48.48 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(-c2ccc(F)cc2C)c(C(=O)OC)c1 CHEMBL1929443 IC50 49.0 nM
CCOC(=O)c1sc(Nc2ccc(C)c(F)c2)nc1-c1ccccc1 CHEMBL3410595 IC50 49.0 nM
COc1ncc(Nc2ccc(C3CC3)cc2C(=O)O)cc1-c1ccccc1 CHEMBL3674628 IC50 49.0 nM
CN(C)c1ccc(-c2ccc(NC(=O)C3=C(C(=O)O)CCC3)cc2Cl)cc1 CHEMBL154151 IC50 50.0 nM
Cc1c(-c2ccc(-c3cccc(F)c3)cc2)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL38978 Ki 50.0 nM
Cc1cc(C(=O)O)c2nc(-c3c(F)c(F)c(-c4ccsc4)c(F)c3F)[nH]c2c1 CHEMBL3677824 IC50 50.0 nM
[2H]C([2H])([2H])Oc1cccc(-c2cc(F)c(NC(=O)C3=C(C(=O)NS(C)(=O)=O)CCC3)c(F)c2)c1 CHEMBL5429444 IC50 50.0 nM
Cc1cc(O)n2nc(SCc3cc(Cl)ccc3Cl)nc2n1 CHEMBL2177858 IC50 51.0 nM
O=C(O)c1cc(-c2ccc(-c3ccccc3)cc2)nc2ccccc12 CHEMBL3600460 IC50 51.0 nM
O=C([O-])c1c2c(nc3ccc(F)cc13)-c1ccc(-c3ccsc3)cc1CC2 CHEMBL107224 Ki 52.0 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(-c2ccccc2Cl)c(C(=O)OC)c1 CHEMBL1929436 IC50 52.0 nM
COC(=O)c1ccc2cc(CCCCc3c(C(=O)O)[nH]c(=O)[nH]c3=O)ccc2c1 CHEMBL3938624 IC50 52.1 nM
COc1cccc(-c2cc(F)c(NC(=O)/C(C#N)=C(/C)O)cc2OC)c1 CHEMBL5175336 IC50 52.1 nM
COc1cccc(-c2cc(F)c(Nc3ncccc3C(=O)O)c(F)c2)c1F CHEMBL2263642 pIC50 52.97 nM
Cc1ccc(Nc2cnc(-c3ccccc3)c(C)c2)c(C(=O)O)c1 CHEMBL3674646 IC50 53.0 nM
[2H]C([2H])([2H])Oc1cccc(-c2ccc(NC(=O)C3=C(C(=O)O)CCC3)c3c2CCC3)c1 CHEMBL5406415 IC50 53.0 nM
Cc1ccc2nc(-c3ccc(-c4cccnc4Cl)cc3)c(C)c(C(=O)O)c2c1 CHEMBL4224891 IC50 54.2 nM
Cc1c(-c2ccc(-c3cccnc3Cl)cc2)nc2ccccc2c1C(=O)O CHEMBL4225759 IC50 54.3 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)c2cccc(Cl)c2)cc1F CHEMBL5394812 IC50 54.8 nM
COc1ccc(-c2ccc3c(c2)CCc2c-3nc3ccc(F)cc3c2C(=O)[O-])cc1 CHEMBL441276 Ki 55.0 nM
Cc1ccc(C(=O)N[C@@H]2CCCc3c2cnn3-c2ccccc2F)nc1 CHEMBL4647721 IC50 55.0 nM
Cc1c(-c2ccc(-c3cccs3)cc2)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL41799 Ki 56.0 nM
Cc1cc(C(=O)O)c2nc(-c3c(F)c(F)c(-c4ccc(NC(=O)C5CCCN5)cc4)c(F)c3F)[nH]c2c1 CHEMBL3677770 IC50 56.0 nM
O=C1c2ccccc2C(=O)c2c1nnn2-c1ccc(-c2cccc(F)c2)cc1 CHEMBL4645170 IC50 56.0 nM
O=C(O)c1cc(C2CC2)ccc1Nc1cnc(-c2c(F)cc(O)cc2F)nc1 CHEMBL3674627 IC50 57.0 nM
O=C(O)c1cc(C2CC2)ccc1Nc1cnc(-c2ccccc2C2CC2)nc1 CHEMBL3674630 IC50 57.0 nM
Cc1ccc(Nc2cnc(-c3ccccc3Cl)nc2)c(C(=O)O)c1 CHEMBL3674667 IC50 57.0 nM
CCN(CC)C(=O)N(C)c1cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(F)cccc2Cl)cc1F CHEMBL5439460 IC50 57.0 nM
O=C(O)c1cc(-c2ccc(Cl)c(Cl)c2)nc2ccc(Br)cc12 CHEMBL3818640 IC50 57.1 nM
O=C(O)C1=C(C(=O)Nc2c(F)c(F)c(-c3cccc(OC(F)(F)F)c3)c(F)c2F)COC1 CHEMBL194954 IC50 58.0 nM
CCOC(=O)c1sc(Nc2ccc(C)c(C)c2)nc1-c1ccccc1 CHEMBL3410594 IC50 58.0 nM
Cc1cccc(-c2ccc3c(c2)CCc2c-3nc3ccc(F)cc3c2C(=O)[O-])c1 CHEMBL104766 Ki 59.0 nM
CCOc1cccc(-c2ccc(NC(=O)/C(C#N)=C(\O)CC)cc2C(=O)OC)c1 CHEMBL1929448 IC50 59.0 nM
CCN(/N=C/c1ccccc1C(=O)O)c1nc(-c2ccccc2Cl)cs1 CHEMBL3910373 IC50 59.0 nM
CCCCCCc1ccc(-c2nc3ccc(F)cc3c(C(=O)O)c2C)cc1 CHEMBL36981 Ki 60.0 nM
Cc1cc(C(=O)O)c2[nH]c(-c3c(F)c(F)c(-c4ccccc4OCc4ccccc4)c(F)c3F)nc2c1 CHEMBL3677785 IC50 60.0 nM
Cc1ccc(Nc2cc(Cl)cnc2-c2ccccc2)c(C(=O)O)c1 CHEMBL3674632 IC50 62.0 nM
Cc1c(-c2cccc(Oc3ccccc3)c2)nc2ccc(F)cc2c1C(=O)O CHEMBL290674 Ki 63.0 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)c2cccc(F)c2)cc1F CHEMBL5424051 IC50 63.5 nM
O=C(c1ccccc1)c1ccc(Nc2ncccc2C(=O)O)c(Cl)c1 CHEMBL5423324 IC50 63.5 nM
[2H]C([2H])([2H])Oc1cccc(-c2cc(F)c(NC(=O)C3=C(C(=O)O)CCC3)c(F)c2)c1 CHEMBL5417026 IC50 64.0 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(-c2ccc(F)cc2OC)c(C(=O)OC)c1 CHEMBL1929447 IC50 66.0 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(-c2ccc3c(c2)OCCO3)c(C(=O)OC)c1 CHEMBL1929451 IC50 66.0 nM
Cc1sc(N/N=C/c2ccccc2C(=O)O)nc1-c1ccccc1Cl CHEMBL3891218 IC50 66.0 nM
O=C(c1ccccc1)c1ccc(Nc2ncccc2C(=O)O)c(F)c1 CHEMBL5427310 IC50 66.1 nM
O=C1C(O)=C(CC=C(Cl)Cl)C(=O)c2ccccc21 CHEMBL1990817 IC50 67.0 nM
COc1ccc2cccc(CCc3c(C(=O)O)[nH]c(=O)[nH]c3=O)c2c1 CHEMBL3904389 IC50 68.1 nM
COc1cccc(C(=O)c2cc(F)c(NC(=O)/C(C#N)=C(/C)O)cc2O[C@@H](C)C(F)(F)F)c1 CHEMBL5396928 IC50 69.1 nM
O=C(O)C1=C(C(=O)Nc2ccc(-c3ccc(Br)cc3)c(Cl)c2)CCC1 CHEMBL348871 IC50 70.0 nM
Cc1cc(NC(=O)c2c(O)nn3ccccc23)c(C(C)C)cc1Oc1ccncc1 CHEMBL5183718 IC50 70.0 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)c2ccc(Cl)cc2)cc1F CHEMBL5430092 IC50 70.5 nM
Cc1c(-n2cnc3c(-c4ccccc4)cccc32)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL49331 Ki 71.0 nM
O=C(Nc1c(F)c(F)c(-c2ccc(C(F)(F)F)cc2)c(F)c1F)c1c(O)nn2ccccc12 CHEMBL5079952 IC50 71.8 nM
C/C(O)=C(\C#N)C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)c2ccc(F)cc2)cc1F CHEMBL5424393 IC50 71.8 nM
CCNC(=O)Nc1ccc(S(=O)(=O)Oc2ccccc2CC)cc1 CHEMBL2165736 IC50 72.0 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(-c2ccccc2)c(C(=O)OC)c1 CHEMBL1929434 IC50 73.0 nM
Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc2c1C(=O)C(F)(F)F CHEMBL4785347 IC50 74.0 nM
C=C1CC[C@H](O)C(C)(C)[C@@H]1CC/C(C)=C/Cc1c(O)c(Cl)c(C)c(C=O)c1O CHEMBL4854072 IC50 74.0 nM
Cc1ccc(-c2ccc(-c3nc4ccc(Cl)cc4c(C(=O)O)c3C)cc2)c(Cl)n1 CHEMBL4227841 IC50 74.4 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(-c2ccc3c(c2)OCO3)c(C(=O)OC)c1 CHEMBL1929449 IC50 76.0 nM
CC(C)c1ccc(-c2c(F)cc(-n3nnc4c3C(=O)c3ccccc3C4=O)cc2F)cc1 CHEMBL4636651 IC50 76.0 nM
Cc1ccc(Nc2ccc(-c3c(F)ccc(F)c3F)nc2)c(C(=O)O)c1 CHEMBL3674676 IC50 77.0 nM
COC(=O)c1ccc2cc(CCc3c(C(=O)O)[nH]c(=O)[nH]c3=O)ccc2c1 CHEMBL3960727 IC50 77.5 nM
CCOc1cccc(-c2cc(C)c(Nc3ccc(C)cc3C(=O)O)cn2)c1 CHEMBL3674641 IC50 78.0 nM
Cc1cc(C(=O)O)c2nc(-c3c(F)c(F)c(-c4ccc(CN5CCCCC5)cc4)c(F)c3F)[nH]c2c1 CHEMBL3677768 IC50 78.0 nM
Cc1cc(C(=O)O)c2c(c1)nc(-c1c(F)c(F)c(-c3ccc(O)cc3)c(F)c1F)n2CCO CHEMBL3677779 IC50 78.0 nM
Cc1c(-c2ccc(-c3cccnc3F)cc2)nc2ccc(F)cc2c1C(=O)O CHEMBL4228942 IC50 79.4 nM
CC(C)(C)c1ccc(-c2ccc(NC(=O)C3=C(C(=O)O)CCC3)cc2Cl)cc1 CHEMBL157164 IC50 80.0 nM
Cc1cccc(-c2ccc3c(n2)CCc2c-3nc3ccc(F)cc3c2C(=O)[O-])c1 CHEMBL104167 Ki 81.0 nM
Cc1sc(N/N=C/c2ccccc2C(=O)O)nc1-c1ccccc1 CHEMBL3968151 IC50 81.0 nM
O=C(O)c1[nH]c(=O)[nH]c(=O)c1CCc1ccc(OC(F)(F)F)cc1 CHEMBL3986776 IC50 82.4 nM
Cc1c(Nc2cccc(-c3ccccc3)c2)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL50441 Ki 83.0 nM
CN(/N=C/c1ccc(C(F)(F)F)cc1C(=O)O)c1nc(-c2ccccc2Cl)cs1 CHEMBL3950655 IC50 87.0 nM
COc1cccc(-c2cc(F)c(Nc3ncccc3C(=O)O)cc2F)c1 CHEMBL2263628 pIC50 87.9 nM
O=C(O)c1cccnc1Nc1c(F)cc(-c2cccc(OC3CCC3)c2)cc1F CHEMBL2263630 pIC50 89.95 nM
COc1ccc(-c2cc(F)c(NC(=O)C3=C(C(=O)O)CCC3)c(F)c2)c(OC)c1 CHEMBL345652 IC50 90.0 nM
Cc1ccc(Nc2ccc(-c3ccncc3F)nc2)c(C(=O)O)c1 CHEMBL3674664 IC50 90.0 nM
O=C(Nc1c(F)c(F)c(N2CCOCC2)c(F)c1F)c1c(O)nn2ccccc12 CHEMBL5090397 IC50 90.9 nM
CC(C)CNC(=O)c1cc(C(=O)NCc2ccccc2)nn1-c1ccc(Cl)cc1 CHEMBL141304 Ki 91.0 nM
Cc1ccc(Nc2ccc(-c3ccccc3F)nc2)c(C(=O)O)c1 CHEMBL3674645 IC50 91.0 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(OS(=O)(=O)C(F)(F)F)c(C(=O)OC)c1 CHEMBL1929433 IC50 93.0 nM
CC(C)N(/N=C/c1ccccc1C(=O)O)c1nc(-c2ccccc2Cl)cs1 CHEMBL3937185 IC50 93.0 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)OCCOCCOCCOc2ccc(-c3ccc(-c4nc5ccc(F)cc5c(C(=O)O)c4C)cc3)c(F)c2)C(C)(C)C)cc1 CHEMBL5202345 IC50 93.0 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)OCCOCCOCCOc2ccc(-c3ccc(-c4nc5ccc(F)cc5c(C(=O)O)c4C)cc3)cc2)C(C)(C)C)cc1 CHEMBL5201197 IC50 93.0 nM
O=C(O)c1cc(-c2ccc(Oc3ccccc3)cc2)nc2ccc(Cl)cc12 CHEMBL2385514 IC50 95.0 nM
O=C(NC1CCCc2c1cnn2-c1ccccc1)c1onc2c1CCCC2 CHEMBL4649494 IC50 95.0 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(-c2ccc(F)c(F)c2)c(C(=O)OC)c1 CHEMBL1929445 IC50 97.0 nM
COc1ccc(F)c(-c2cc(C)c(Nc3ccc(C)cc3C(=O)O)cn2)c1 CHEMBL3674651 IC50 97.0 nM
Cc1ccc(Nc2ccc(-c3cccc(C(F)(F)F)c3)nc2)c(C(=O)O)c1 CHEMBL3674626 IC50 98.0 nM
O=C1c2cc(F)ccc2C(=O)c2c1nnn2-c1cc(F)c(-c2ccccc2F)c(F)c1 CHEMBL4638560 IC50 98.0 nM
COc1cccc(-c2cc(F)c(Nc3ncccc3C(=O)O)cc2C)c1 CHEMBL2263639 IC50 99.0 nM
CN(Cc1cccnc1)c1ccc(NC(=O)C2CC2)c(C(=O)O)c1 CHEMBL1084928 IC50 100.0 nM
CC(C)=CCC1=C(O)C(=O)c2ccccc2C1=O CHEMBL15193 IC50 100.0 nM
COc1cccc(-c2ccc(-n3nnc4c3C(=O)c3ccccc3C4=O)cc2)c1 CHEMBL4649642 IC50 100.0 nM
CC(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(F)cccc2Cl)cc1F CHEMBL5399005 IC50 100.0 nM
CCNC(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(F)cccc2Cl)cc1F CHEMBL5395154 IC50 100.0 nM
COC(=O)c1c(-c2c(Cl)cccc2Cl)noc1-c1cnn(-c2cccc(Cl)c2)c1C(F)(F)F CHEMBL4562509 IC50 103.0 nM
O=C(O)C1=C(C(=O)Nc2cc(Br)c(OCc3c(F)cccc3Cl)c(Br)c2)CSC1 CHEMBL194776 IC50 105.0 nM
O=C(O)c1cc(C2CC2)ccc1Nc1cnc(-c2ccccc2)nc1 CHEMBL3674625 IC50 105.0 nM
O=C1C(O)=C(Nc2cccc(C(F)(F)F)c2)C(=O)c2ccccc21 CHEMBL4472078 IC50 108.0 nM
Cc1ccc(Nc2ccc(-c3ccncc3Cl)nc2)c(C(=O)O)c1 CHEMBL3674638 IC50 109.0 nM
Cc1cnc(Nc2ccc(-c3cccc(OC(F)(F)F)c3)cc2F)c(C(=O)O)c1 CHEMBL2263636 pIC50 109.9 nM
O=C(O)C1=C(C(=O)Nc2cc(Br)c(OCc3c(F)cccc3Cl)c(Br)c2)CCC1 CHEMBL196181 IC50 110.0 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(-c2ccc(F)cc2)c(C(=O)OC)c1 CHEMBL1929435 IC50 110.0 nM
O=Cc1ccccc1/C=N/Nc1nc(-c2ccccc2)cs1 CHEMBL2178104 IC50 110.0 nM
Cc1ccc(C)n1-c1c(F)c(F)c(-c2nc3cccc(C(=O)O)c3[nH]2)c(F)c1F CHEMBL3677795 IC50 110.0 nM
O=C(O)c1cc(C2CC2)ccc1Nc1cncc(-c2ccccc2)c1 CHEMBL3674631 IC50 113.0 nM
O=C(O)c1cc(C2CC2)ccc1Nc1cnc(-c2cccc(OC3CC3)c2)nc1 CHEMBL3674634 IC50 114.0 nM
Cc1cc(Oc2ccccc2)c(C(C)C)cc1NC(=O)c1c(O)nn2ccccc12 CHEMBL5209405 IC50 114.0 nM
Cc1cc(C(=O)O)c2nc(-c3c(F)c(F)c(-c4ccccc4)c(F)c3F)n(C)c2c1 CHEMBL3677798 IC50 116.0 nM
Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc2c1C(=O)NC#N CHEMBL4743387 IC50 116.0 nM
Cc1cc(C(=O)O)c2nc(-c3c(F)c(F)c(-c4ccc(F)cc4)c(F)c3F)[nH]c2c1 CHEMBL3677819 IC50 118.0 nM
Cc1ccc(Nc2cnc(N3CCCCCC3)c(C)c2)c(C(=O)O)c1 CHEMBL3674637 IC50 119.0 nM
O=C1C(O)=C(Nc2cccc(Cl)c2Cl)C(=O)c2ccccc21 CHEMBL4540838 IC50 123.0 nM
CCOc1nn(-c2ncc(CC)cn2)c(C)c1Oc1ccccc1Br CHEMBL3409306 pIC50 125.89 nM
O=C(O)C1=C(C(=O)Nc2cc(Br)c(OCc3ccccc3)c(Br)c2)CCC1 CHEMBL197553 IC50 127.0 nM
COc1ccccc1-c1ccc(-c2cc(C(=O)O)c3ccccc3n2)cc1 CHEMBL4229222 IC50 127.0 nM
CCOC(=O)c1sc(Nc2ccc(Br)c(C(F)(F)F)c2)nc1-c1ccccc1 CHEMBL3410603 IC50 128.0 nM
CC(C)=CCc1c(O)ccc(C(=O)/C=C/c2ccc(O)cc2)c1O CHEMBL253467 IC50 130.0 nM
CC(C)=CCC1=C([O-])C(=O)c2ccccc2C1=O CHEMBL2028401 IC50 130.0 nM
COc1cccc(-c2ccc(NC(=O)C3=C(C(=O)O)CSC3)c(F)c2)c1 CHEMBL194023 IC50 131.0 nM
CCOC(=O)c1sc(Nc2ccc(Cl)c(C(F)(F)F)c2)nc1-c1ccccc1 CHEMBL3410602 IC50 131.0 nM
COc1cccc(-c2ccc(NC(=O)C3=C(C(=O)O)CCC3)c(F)c2)c1 CHEMBL197194 IC50 134.0 nM
Cc1cccc(-c2ccc3c(c2)CSc2c-3nc3ccc(F)cc3c2C(=O)[O-])c1 CHEMBL108213 Ki 135.0 nM
CC(C)c1ccc(-c2cc(C(=O)O)c3cc(Br)ccc3n2)cc1 CHEMBL3818257 IC50 136.2 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(-c2cc(F)c(F)c(F)c2)c(C(=O)OC)c1 CHEMBL1929446 IC50 137.0 nM
COc1ccc(-n2nc(C(=O)NCC(C)C)cc2C(=O)Nc2ccc(C(=O)N3CCCC3)cc2)cc1 CHEMBL143345 Ki 138.0 nM
COc1cccc(-c2ncc(Nc3ccc(C(F)(F)F)cc3C(=O)O)cc2C)c1 CHEMBL3674642 IC50 138.0 nM
O=C([O-])c1c2c(nc3ccc(F)cc13)-c1ccc(-c3ccccc3)cc1S(=O)(=O)C2 CHEMBL108327 Ki 139.0 nM
O=C(O)c1ccccc1/C=N/Nc1nc(-c2ccccc2)cs1 CHEMBL3949527 IC50 139.0 nM
Cc1c(-c2ccc(-c3ccc(Cl)cc3)cc2)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL38639 Ki 140.0 nM
O=C(O)c1cc(Cl)ccc1Nc1ccc(-c2ccccc2Cl)nc1 CHEMBL3674662 IC50 145.0 nM
Cc1ccc(Nc2ccc(-c3ccc(F)cc3F)nc2)c(C(=O)O)c1 CHEMBL3674678 IC50 146.0 nM
COC(=O)c1cccc(CCCCc2c(C(=O)O)[nH]c(=O)[nH]c2=O)c1 CHEMBL3901641 IC50 147.0 nM
O=C(O)c1cc(-c2ccc(-c3cccnc3C(F)(F)F)cc2)nc2ccccc12 CHEMBL4227002 IC50 148.0 nM
CC(C)COc1ccc(-c2cc(C(=O)O)c3ccccc3n2)cc1OCC(C)C CHEMBL5178031 IC50 148.0 nM
COc1cccc(-c2ccc(Nc3ncccc3C(=O)O)c(Cl)c2)c1 CHEMBL2263629 pIC50 149.97 nM
Cc1cc(-c2cccc(OC(F)(F)F)c2)ccc1NC(=O)C1=C(C(=O)O)CCC1 CHEMBL155597 IC50 150.0 nM
Cc1c(-c2ccc(-c3ccccc3)cc2)nc2c(Cl)cccc2c1C(=O)O CHEMBL40182 Ki 150.0 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(OS(=O)(=O)C(F)(F)F)cc1 CHEMBL1929432 IC50 150.0 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(-c2ccc(F)nc2)c(C(=O)OC)c1 CHEMBL1929444 IC50 150.0 nM
O=C(Nc1c(F)c(F)c(-c2ccnc(C(F)(F)F)c2)c(F)c1F)c1c(O)nn2ccccc12 CHEMBL5080170 IC50 150.0 nM
[2H]C([2H])([2H])Oc1cccc(-c2cc(F)c(NC(=O)C3=C(C(=O)NOC)CCC3)c(F)c2)c1 CHEMBL5439713 IC50 150.0 nM
O=C(O)c1[nH]c(=O)[nH]c(=O)c1CCCCc1ccc2c(C(=O)O)cccc2c1 CHEMBL3981004 IC50 152.0 nM
O=C1c2ccc(F)cc2C(=O)c2c1nnn2-c1cc(F)c(-c2ccccc2F)c(F)c1 CHEMBL4643209 IC50 152.0 nM
Cc1cc(C(=O)O)c2nc(-c3ccc(-c4cnn(Cc5ccccc5)c4)cc3)[nH]c2c1 CHEMBL3677796 IC50 155.0 nM
CCC(CC)C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(F)cccc2Cl)cc1F CHEMBL5404114 IC50 158.0 nM
Cc1c(Nc2nc3c(s2)CCCC3=O)cc(Cl)cc1OC1CCN(C(=O)CC(C(F)(F)F)C(F)(F)F)CC1 CHEMBL5085951 IC50 159.0 nM
COc1cccc(-c2ccc3c(n2)CCc2c-3nc3ccc(F)cc3c2C(=O)[O-])c1 CHEMBL106529 Ki 160.0 nM
Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc2c1C(F)F CHEMBL4748668 IC50 160.0 nM
COc1ncccc1-c1ccc(-c2cc(C(=O)O)c3ccccc3n2)cc1 CHEMBL4228376 IC50 165.0 nM
Cc1c(-c2ccc(-c3cccnc3F)cc2)nc2ccc(Cl)cc2c1C(=O)O CHEMBL4224790 IC50 165.0 nM
Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc2c1CO CHEMBL4799525 IC50 166.0 nM
COc1cccc(-c2ccc(NC(=O)C3=C(C(=O)O)CCC3)c(OC)c2)c1 CHEMBL154372 IC50 170.0 nM
O=C([O-])c1c2c(nc3ccc(F)cc13)-c1ccc(-c3ccccc3)cc1CS2 CHEMBL320245 Ki 170.0 nM
O=C(N[C@@H]1CCCc2c1cnn2-c1ccccc1F)c1ccccn1 CHEMBL4634816 IC50 170.0 nM
Cc1cc(C(=O)O)c2[nH]c(-c3ccc(-c4ccccc4F)cc3F)nc2c1 CHEMBL3677740 IC50 172.0 nM
Cc1c(Nc2nc3c(s2)CCC[C@H]3O)cc(Cl)cc1OC1CCN(C(=O)CC(C(F)(F)F)C(F)(F)F)CC1 CHEMBL5086318 IC50 172.0 nM
CCCCc1ccc(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccc(C)cc2)nc1 CHEMBL5171775 IC50 172.0 nM
O=C(O)C1=C(C(=O)Nc2cc(Br)c(OCc3ccccc3)c(Br)c2)CSC1 CHEMBL195246 IC50 173.0 nM
CCOC(=O)c1sc(Nc2ccc(Cl)c(Cl)c2)nc1-c1ccccc1 CHEMBL3410604 IC50 174.0 nM
Cc1cc(C(=O)O)c2nc(-c3c(F)cc(-c4ccccc4)cc3F)[nH]c2c1 CHEMBL3677752 IC50 177.0 nM
O=C(c1ccccc1)c1ccc(Nc2ncccc2C(=O)O)cc1 CHEMBL5419515 IC50 177.8 nM
COc1ccccc1NC(=O)c1cccc2nc(-c3cc(Br)nn3-c3ncccc3Cl)[nH]c12 CHEMBL3808600 IC50 178.0 nM
O=C(O)C1=C(C(=O)Nc2ccc(-c3cccc4ccccc34)cc2C(F)(F)F)CCC1 CHEMBL349577 IC50 180.0 nM
Cc1ccc(-c2ccc(-c3nc4ccccc4c(C(=O)O)c3C)cc2)c(Cl)n1 CHEMBL4226599 IC50 184.0 nM
O=C([O-])c1c2c(nc3ccc(F)cc13)-c1ccc(-c3ccoc3)cc1CC2 CHEMBL326692 Ki 190.0 nM
C/C(O)=C(\C#N)C(=O)Nc1ccc(-c2cccc(Cl)c2)cc1Cl CHEMBL484595 Ki(app) 190.0 nM
CCOc1cccc(-c2ccc(Nc3ccc(C)cc3C(=O)O)cn2)c1 CHEMBL3674639 IC50 190.0 nM
Cc1ccc(Nc2cnc(-c3cccc(C(N)=O)c3)c(C)c2)c(C(=O)O)c1 CHEMBL3674650 IC50 190.0 nM
CC/C(O)=C(\C#N)C(=O)Nc1ccc(-c2cccc(F)c2)c(C(=O)OC)c1 CHEMBL1929440 IC50 198.0 nM
O=C([O-])c1ccncc1Nc1ccc(-c2cccc(OC(F)(F)F)c2)cc1F CHEMBL2263635 pIC50 199.99 nM
CCOc1cccc(-c2ccc(Nc3ncccc3C(=O)O)c(F)c2)c1 CHEMBL2263627 pIC50 199.99 nM
C/C(O)=C(/C#N)C(=O)Nc1ccc(C(F)(F)F)cc1 CHEMBL999 IC50 200.0 nM
Cc1c(-c2ccc(-c3cccnc3)cc2)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL39151 Ki 200.0 nM
N#Cc1c(-c2ccc(-c3ccccc3OC(F)(F)F)cc2)nc2ccncc2c1O CHEMBL1957366 IC50 200.0 nM
[2H]C([2H])([2H])Oc1ccccc1-c1cc(F)c(NC(=O)C2=C(C(=O)O)CCC2)c(F)c1 CHEMBL5398990 IC50 200.0 nM
Cc1c(-c2ccc(-c3cccnc3Cl)cc2)nc2cnc(C(F)(F)F)cc2c1C(=O)O CHEMBL4228585 IC50 201.0 nM
O=C(N[C@@H]1CCCc2c1[nH]c1ccc(Cl)cc21)c1ccccn1 CHEMBL551051 Ki 203.0 nM
COC(=O)c1ccccc1CCCCc1c(C(=O)O)[nH]c(=O)[nH]c1=O CHEMBL3956130 IC50 204.0 nM
O=C(O)C1=C(C(=O)Nc2c(F)cc(-c3cccc(OC(F)(F)F)c3)cc2F)COC1 CHEMBL195163 IC50 205.0 nM
O=C([O-])c1c2c(nc3ccc(F)cc13)-c1ccc(-c3ccccc3)cc1[S+]([O-])C2 CHEMBL324668 Ki 206.0 nM
O=C(O)c1cccc2[nH]c(-c3c(F)c(F)c(-c4cccc(F)c4F)c(F)c3F)nc12 CHEMBL3677813 IC50 209.0 nM
O=C(O)c1cc(-c2ccc(-c3ccccc3)cc2)nc2sccc12 CHEMBL38669 Ki 210.0 nM
Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ncccc2c1C(=O)O CHEMBL289071 Ki 210.0 nM
Cc1c(-c2ccc(-c3ccc(F)cc3)cc2)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL39188 Ki 210.0 nM
CC(=O)Nc1ccc(-c2ccc(-c3nc4c(C(=O)O)cc(C)cc4[nH]3)cc2)cc1 CHEMBL3593251 IC50 210.0 nM
Cc1ccc(NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2Cc3ccccc3CN2)cc1 CHEMBL5176340 IC50 210.0 nM
O=C(O)c1c(O)c(-c2ccc(Cl)cc2)nc2ccc(Br)cc12 CHEMBL218700 IC50 211.0 nM
Cc1ccc2nc(-c3ccc(Cl)cc3)c(O)c(C(=O)O)c2c1 CHEMBL217918 IC50 217.0 nM
Cc1ccc(-c2ccc3c(c2)CSc2c-3nc3ccc(F)cc3c2C(=O)[O-])cc1 CHEMBL106674 Ki 218.0 nM
O=C(O)c1cccc2[nH]c(-c3c(F)c(F)c(-c4cccc(OC(F)(F)F)c4)c(F)c3F)nc12 CHEMBL3677832 IC50 218.0 nM
Cc1c(-c2ccc(-c3ccccc3)cc2)nc2cc(Cl)ccc2c1C(=O)O CHEMBL40220 Ki 220.0 nM
Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc2c1-c1nnn[nH]1 CHEMBL4788745 IC50 223.0 nM
COc1cc(-c2ccccc2Cl)ccc1NC(=O)C1=C(C(=O)O)CCC1 CHEMBL155732 IC50 225.0 nM
CC/C(=C\CO)C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(F)cccc2Cl)cc1F CHEMBL5421173 IC50 226.0 nM
Cc1c(-c2ccc(-c3ccc(C(F)(F)F)cc3)cc2)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL38476 Ki 230.0 nM
O=C1c2ccccc2C(=O)c2c1nnn2-c1ccc(-c2ccccc2O)cc1 CHEMBL4648838 IC50 230.0 nM
Cc1ccc(-c2ccc(-c3cc(C(=O)O)c4ccccc4n3)cc2)c(Cl)n1 CHEMBL4225816 IC50 235.0 nM
CCOC(=O)c1sc(Nc2ccc(Cl)cc2)nc1-c1ccccc1 CHEMBL3410599 IC50 239.0 nM
Cc1c(N(C)c2cccc(-c3ccccc3)c2)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL430760 Ki 240.0 nM
O=C(O)c1cc(-c2ccc(C3CCCCC3)cc2)nc2ccccc12 CHEMBL4226040 IC50 250.0 nM
Cc1c(-c2ccc(-c3cccnc3Cl)cc2)nc2cnccc2c1C(=O)O CHEMBL4227801 IC50 259.0 nM
CCCOc1ccc(-c2cc(C(=O)O)c3cc(Cl)ccc3n2)cc1 CHEMBL2385715 IC50 260.0 nM
CSc1ccc2nc(-c3ccc(-c4ccccc4)cc3)c(C)c(C(=O)O)c2c1 CHEMBL433445 Ki 270.0 nM
O=C(O)c1c(O)c(-c2ccc(Cl)cc2)nc2ccc(C(F)(F)F)cc12 CHEMBL386700 IC50 270.0 nM
O=C(O)C1=C(C(=O)Nc2c(F)cc(-c3cccc4ocnc34)cc2F)CCC1 CHEMBL5432354 IC50 270.0 nM
O=C(O)c1cc(F)cc2[nH]c(-c3c(F)cc(-c4ccccc4)cc3F)nc12 CHEMBL3677763 IC50 276.0 nM
COCOc1ccc2cc(CCc3c(C(=O)O)[nH]c(=O)[nH]c3=O)ccc2c1 CHEMBL3917382 IC50 277.0 nM
O=C(O)C1=C(C(=O)Nc2ccc(-c3cccc(OC(F)(F)F)c3)cc2F)CCC1 CHEMBL154493 IC50 280.0 nM
O=C(O)c1cccc2[nH]c(-c3c(F)c(F)c(-c4cccnc4)c(F)c3F)nc12 CHEMBL3677821 IC50 282.0 nM
CCOC(=O)c1sc(Nc2ccc(C(C)(C)C)cc2)nc1-c1ccccc1 CHEMBL3410601 IC50 284.0 nM
O=C(O)c1[nH]c(=O)[nH]c(=O)c1CCc1cccc(C(F)(F)F)c1 CHEMBL3899009 IC50 284.0 nM
O=C(O)C1=C(C(=O)Nc2ccc(-c3cccc(OC(F)(F)F)c3)cc2Cl)CCC1 CHEMBL155548 IC50 290.0 nM
Cc1cc(CCc2c(C(=O)O)[nH]c(=O)[nH]c2=O)ccc1F CHEMBL3908056 IC50 293.0 nM
CNC(=O)c1cccc2cc(CCc3c(C(=O)O)[nH]c(=O)[nH]c3=O)ccc12 CHEMBL3947426 IC50 297.0 nM
Cc1c(Nc2nc3c(s2)CCCC3O)cc(Cl)cc1OC1CCN(C(=O)CC(C(F)(F)F)C(F)(F)F)CC1 CHEMBL5093830 IC50 297.0 nM
O=C([O-])c1c2c(nc3ccc(F)cc13)-c1cccc(-c3ccccc3)c1CC2 CHEMBL106930 Ki 300.0 nM
Cc1c(-c2ccc3ccccc3c2)nc2ccc(F)cc2c1C(=O)O CHEMBL289555 Ki 300.0 nM
CC(=O)Nc1ccccc1COc1ccc(-c2ccc(-c3nc4c(C(=O)O)cc(C)cc4[nH]3)cc2)cc1 CHEMBL3593804 IC50 300.0 nM
COc1cc(-c2cc(C(=O)O)c3ccccc3n2)ccc1OCC(=O)Nc1ccccc1C(F)(F)F CHEMBL4878984 IC50 300.0 nM
O=C(O)C1=C(C(=O)Nc2c(F)cc(-c3cccc4c3OCO4)cc2F)CCC1 CHEMBL5415127 IC50 300.0 nM
CCn1c(CO)nn(-c2nc(SC(C)C)c(C(=O)Nc3c(F)cccc3Cl)cc2F)c1=O CHEMBL5201472 IC50 302.0 nM
O=C(Nc1ccc(-c2ccccc2)cc1)c1ccsc1C(=O)O CHEMBL381043 IC50 303.0 nM
Cc1cc(C(=O)O)c2nc(-c3ccc(-c4ccccc4)cc3)[nH]c2c1 CHEMBL3677732 IC50 304.0 nM
COc1ccccc1-c1ccc(NC(=O)C2=C(C(=O)O)CCC2)c(Cl)c1 CHEMBL157277 IC50 310.0 nM
O=C(O)c1cc(-c2ccc(OC(F)(F)F)cc2)nc2ccc(Cl)cc12 CHEMBL2385719 IC50 310.0 nM
COc1cc2c(cc1C(=O)Nc1ccc(C(C)(C)C#N)cc1)CCCCC2 CHEMBL4860581 IC50 310.0 nM
[2H]C([2H])([2H])Oc1cccc(-c2cc(F)c(NC(=O)C3=C(C(=O)NC#N)CCC3)c(F)c2)c1 CHEMBL5437165 IC50 310.0 nM
CCOC(=O)c1sc(Nc2c(F)cc(-c3cccc(OC)c3)cc2F)nc1-c1ccccc1 CHEMBL3410616 IC50 311.0 nM
O=C(O)c1c(O)c(-c2ccc(Cl)cc2)nc2ccc(F)cc12 CHEMBL218464 IC50 312.0 nM
Cc1cc(C(=O)O)c2nc(-c3c(F)c(F)c(-c4ccc(F)c(F)c4)c(F)c3F)[nH]c2c1 CHEMBL3677829 IC50 314.0 nM
CCOC(=O)c1sc(Nc2ccc(C)c(C)c2)nc1C1CC1 CHEMBL3410588 IC50 325.0 nM
Cc1c(OCc2cccc(-c3ccccc3)c2)nc2ccc(F)cc2c1C(=O)[O-] CHEMBL51927 Ki 330.0 nM
O=C1C(O)=C(Nc2ccc(F)cc2)C(=O)c2ccccc21 CHEMBL4566973 IC50 330.0 nM
COc1ccc(-n2nc(C(=O)NCC3CCCO3)cc2C(=O)Nc2ccc(C(=O)N3CCCC3)cc2)cc1 CHEMBL442030 Ki 331.0 nM
COc1cccc(-c2ccc(NC(=O)c3cocc3C(=O)O)c(F)c2)c1 CHEMBL370228 IC50 340.0 nM
O=C(Nc1nc2ccccc2s1)c1cccc(C(Cl)(Cl)Cl)c1 CHEMBL2178105 IC50 340.0 nM
Cc1cc(C(=O)O)c2[nH]c(-c3ccc(-c4c(F)cccc4F)cc3)nc2c1 CHEMBL3677766 IC50 344.0 nM
Cc1cc(C(=O)O)c2nc(-c3ccc(-c4ccc(O)cc4)cc3)[nH]c2c1 CHEMBL3677802 IC50 350.0 nM
CCc1sc(N/N=C/c2ccccc2C(=O)O)nc1-c1ccccc1Cl CHEMBL3919303 IC50 356.0 nM
COc1cccc(-c2ccc(NC(=O)C3=C(C(=O)O)COC3)c(F)c2)c1 CHEMBL197455 IC50 360.0 nM
Cc1c(CN2CCN(C(=O)C3CCCC3)CC2)cccc1Nc1nc2c(s1)CCCC2=O CHEMBL5092142 IC50 363.0 nM
COc1cccc(-c2ccc(-c3nc4c(C(=O)O)cccc4[nH]3)c(F)c2)c1 CHEMBL3677727 IC50 368.0 nM
N#Cc1cc(-c2cccc(OC(F)(F)F)c2)ccc1NC(=O)C1=C(C(=O)O)CCC1 CHEMBL154336 IC50 370.0 nM
O=C([O-])c1c2c(nc3ccc(F)cc13)-c1ccc(-c3ccc(C(F)(F)F)cc3)cc1CC2 CHEMBL107362 Ki 370.0 nM
CC(C)COc1cccc(-c2ccc(NC(=O)C3=C(C(=O)O)CCC3)c(F)c2)c1 CHEMBL5408286 IC50 370.0 nM
CCOC(=O)c1sc(Nc2ccc(C)c(Cl)c2)nc1C1CC1 CHEMBL3410590 IC50 372.0 nM
Cc1cc(C(=O)O)c2[nH]c(-c3ccc(-c4ccccc4F)cc3)nc2c1 CHEMBL3677741 IC50 373.0 nM
Cc1ccncc1-c1ccc(-c2cc(C(=O)O)c3ccccc3n2)cc1 CHEMBL4227322 IC50 373.0 nM
O=C(O)c1cccc2[nH]c(-c3c(F)c(F)c(-c4ccc(OCc5ccccc5)cc4)c(F)c3F)nc12 CHEMBL3677817 IC50 378.0 nM
O=C([O-])c1c2c(nc3ccc(F)cc13)-c1cnc(-c3ccccc3)nc1CC2 CHEMBL322100 Ki 380.0 nM
CCCCOc1cccc(-c2ccc(NC(=O)C3=C(C(=O)O)CCC3)c(F)c2)c1 CHEMBL5394449 IC50 380.0 nM
CC(C)(C)OC(=O)N1CCc2cc(CCc3c(C(=O)O)[nH]c(=O)[nH]c3=O)ccc21 CHEMBL3976207 IC50 389.0 nM
O=C(O)C1=C(C(=O)Nc2ccc(-c3cccc(OC(F)(F)F)c3)cc2[N+](=O)[O-])CCC1 CHEMBL155530 IC50 390.0 nM
Cc1c(-c2ccc(-c3ccccc3)s2)nc2ccc(F)cc2c1C(=O)O CHEMBL288381 Ki 390.0 nM
C=C(C)[C@@H](O)CC/C(C)=C/CC/C(C)=C/Cc1c(O)c(Cl)c(C)c(C=O)c1O CHEMBL4854950 IC50 390.0 nM
O=C(O)c1cc(-c2ccc(-c3cccnc3)cc2)nc2ccccc12 CHEMBL4226167 IC50 391.0 nM
CCOC(=O)c1sc(Nc2cc(Cl)cc(Cl)c2)nc1-c1ccccc1 CHEMBL3410605 IC50 393.0 nM
COC(=O)c1c(C)c(-c2ccc(-c3ccccc3)cc2)nc2ccc(F)cc12 CHEMBL38440 Ki 400.0 nM
O=C(O)c1cccnc1Nc1ccc(Cl)cc1 CHEMBL1237007 IC50 400.0 nM
Cc1cc(Oc2ccccc2)ccc1NC(=O)c1c(O)nn2ccccc12 CHEMBL5182435 IC50 400.0 nM
[2H]C([2H])([2H])Oc1cccc(-c2ccc(NC(=O)C3=C(C(=O)O)CCC3)c(F)c2)c1 CHEMBL5405308 IC50 400.0 nM
Cc1cc(C(=O)O)c2[nH]c(-c3ccc(-n4c(C)ccc4C)cc3)nc2c1 CHEMBL3677806 IC50 401.0 nM
Cc1cc(C(=O)O)c2[nH]c(-c3ccc(-c4ccccc4)cc3F)nc2c1 CHEMBL3677743 IC50 403.0 nM
Cc1cc(C(=O)O)c2nc(-c3ccc(-c4cccnc4)cc3)[nH]c2c1 CHEMBL3677759 IC50 407.0 nM
CCOC(=O)c1sc(Nc2ccc(C(F)(F)F)cc2)nc1-c1ccccc1 CHEMBL3410600 IC50 408.0 nM
O=C([O-])c1c2c(nc3ccc(F)cc13)-c1ccc(-c3ccccc3)nc1CC2 CHEMBL104001 Ki 409.0 nM
O=C(O)C1=C(C(=O)Nc2ccc(-c3ccccc3)cc2)CCC1 CHEMBL348270 IC50 410.0 nM
Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccncc2c1C(=O)O CHEMBL39325 Ki 420.0 nM
O=C(O)c1ccccc1Nc1ccc(Cl)cc1 CHEMBL2043303 IC50 420.0 nM
O=C1c2ccccc2C(=O)c2c1nnn2-c1ccc(-c2cccnc2)cc1 CHEMBL4642049 IC50 422.0 nM
O=C(O)c1ccccc1/C=N/N(CCO)c1nc(-c2ccccc2Cl)cs1 CHEMBL3900235 IC50 425.0 nM
Cc1c(Nc2nc3c(s2)CCC[C@@H]3O)cc(Cl)cc1OC1CCN(C(=O)CC(C(F)(F)F)C(F)(F)F)CC1 CHEMBL5075214 IC50 432.0 nM
O=C(O)c1[nH]c(=O)[nH]c(=O)c1CCc1cccc2ccccc12 CHEMBL3955618 IC50 434.0 nM
COC(=O)c1ccc(CCCCc2c(C(=O)O)[nH]c(=O)[nH]c2=O)cc1 CHEMBL3929601 IC50 434.0 nM
CCCCc1ccc(-c2cc(C(=O)O)c3ccccc3n2)cc1 CHEMBL3818502 IC50 436.7 nM
O=C(O)c1cc(F)cc2[nH]c(-c3ccc(-c4cccnc4)cc3)nc12 CHEMBL3677758 IC50 437.0 nM
COc1cc(-c2cc(C(=O)O)c3ccccc3n2)ccc1OCC(C)C CHEMBL5177681 IC50 438.0 nM
O=C(O)c1cccc2[nH]c(-c3c(F)c(F)c(-c4ccsc4)c(F)c3F)nc12 CHEMBL3677828 IC50 441.0 nM
Cc1cc(C(N)=O)c2nc(-c3c(F)c(F)c(-c4ccccc4)c(F)c3F)[nH]c2c1 CHEMBL3677787 IC50 446.0 nM
CCOC(=O)c1sc(Nc2ccc3cc4ccccc4cc3c2)nc1-c1ccccc1 CHEMBL3410611 IC50 453.0 nM
CCNC(=O)c1ccc2cc(CCc3c(C(=O)O)[nH]c(=O)[nH]c3=O)ccc2c1 CHEMBL3908653 IC50 472.0 nM
Cc1cc(NC(=O)c2c(O)nn3ccccc23)ccc1Oc1ccccc1 CHEMBL4167855 IC50 480.0 nM
O=C(O)c1cccc2[nH]c(-c3ccc(-c4ccccc4F)cc3)nc12 CHEMBL3677733 IC50 490.0 nM
CCc1ccc(CCc2c(C(=O)O)[nH]c(=O)[nH]c2=O)cc1 CHEMBL3920594 IC50 496.0 nM
Cc1n[nH]c(Nc2ccc(OC(F)(F)F)cc2)c1C#N CHEMBL118395 IC50 500.0 nM
Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2cccnc2c1C(=O)O CHEMBL289854 Ki 500.0 nM
O=C(O)c1ccccc1N/N=C/c1ccc(-c2ccccc2Cl)o1 CHEMBL1088743 IC50 500.0 nM
O=C(O)c1cccnc1Nc1ccc(OC(F)(F)F)cc1 CHEMBL3914938 IC50 500.0 nM
O=C(O)c1cccc2nc(-c3c(F)c(F)c(-c4cccs4)c(F)c3F)[nH]c12 CHEMBL3677809 IC50 500.0 nM
COc1cc(-c2cc(C(=O)O)c3ccccc3n2)ccc1OCC(=O)Nc1ccccc1F CHEMBL4865759 IC50 500.0 nM
COc1cc(-c2cc(C(=O)O)c3ccccc3n2)ccc1OCC(=O)Nc1cccc(Cl)c1 CHEMBL4856074 IC50 500.0 nM
COc1cc(-c2cc(C(=O)O)c3ccccc3n2)ccc1OCC(=O)Nc1ccc(Cl)cc1 CHEMBL4854748 IC50 500.0 nM
COc1cc(-c2cc(C(=O)O)c3ccccc3n2)ccc1OCC(=O)Nc1cccc(C(F)(F)F)c1 CHEMBL4860193 IC50 500.0 nM
Cc1c(-c2ccc(-c3cccnc3F)cc2)nc2ccccc2c1C(=O)O CHEMBL4225494 IC50 504.0 nM
CCOC(=O)c1sc(Nc2ccc(C)c(C)c2)nc1C(C)(C)C CHEMBL3410591 IC50 515.0 nM
CC(C)C1CC(=O)c2nnn(-c3cc(F)c(-c4ccccc4F)c(F)c3)c2C1 CHEMBL4640504 IC50 520.0 nM
O=C(Nc1cccc2ccc(CCc3c(C(=O)O)[nH]c(=O)[nH]c3=O)cc12)c1ccccc1 CHEMBL3942246 IC50 524.0 nM
O=C1C(O)=C(Nc2ccc(Cl)cc2)C(=O)c2ccccc21 CHEMBL4560384 IC50 541.0 nM
CCc1cccc(NC(=O)/C=C/c2ccc(Cl)c(Cl)c2)c1 CHEMBL2178106 IC50 550.0 nM
COC(=O)c1cccc(-c2ccc(-n3nnc4c3C(=O)c3ccccc3C4=O)cc2)c1 CHEMBL4643388 IC50 550.0 nM
CCOC(=O)c1sc(Nc2ccc(C)c(Cl)c2)nc1C(C)(C)C CHEMBL3410593 IC50 552.0 nM
O=C(CCNC(=O)c1ccc(OC(F)(F)F)cc1)N[C@@H]1CCCc2ccccc21 CHEMBL3184132 IC50 560.0 nM
CC(C)c1ccc(-n2nnc3c2C(=O)c2ccccc2C3=O)cc1 CHEMBL4639376 IC50 560.0 nM
CC(=O)c1sc(Nc2ccc3ccccc3c2)nc1C CHEMBL3410576 IC50 562.0 nM
Cc1c(CN2CCN(C(=O)C3CCCC3)CC2)cccc1Nc1nc2c(s1)CCCC2O CHEMBL5080135 IC50 573.0 nM
O=C(O)c1cc(Br)cc2[nH]c(-c3ccc(-c4ccccc4)cc3)nc12 CHEMBL3677728 IC50 574.0 nM
Cc1c(Nc2nc3c(s2)CCCC3)cc(Cl)cc1OC1CCN(C(=O)CC(C(F)(F)F)C(F)(F)F)CC1 CHEMBL5086624 IC50 588.0 nM
O=C(O)c1cccc2cc(-c3ccc(-c4ccccc4)cc3)[nH]c12 CHEMBL3677760 IC50 595.0 nM
COc1cccc(-c2cc(F)c(NC(=O)C3=C(C(=O)O)CCC3)c(F)c2)n1 CHEMBL5427377 IC50 600.0 nM
CCC(CCO)C(=O)Nc1cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc2c(F)cccc2Cl)cc1F CHEMBL5426062 IC50 601.0 nM
CN(C)c1ccc(-c2cc(F)c(NC(=O)C3=C(C(=O)O)CCC3)c(F)c2)cc1 CHEMBL154613 IC50 610.0 nM
O=C(O)C1=C(C(=O)Nc2ccc(-c3cccc(O)c3)cc2F)CCC1 CHEMBL345685 IC50 610.0 nM
O=C(O)c1cc(F)cc2[nH]c(-c3ccc(-c4ccccc4)cc3F)nc12 CHEMBL3677744 IC50 623.0 nM
O=C(O)c1ccccc1CCCCc1c(C(=O)O)[nH]c(=O)[nH]c1=O CHEMBL3910672 IC50 638.0 nM
COc1cc(-c2cc(F)c(NC(=O)C3=C(C(=O)O)CCC3)c(F)c2)ccn1 CHEMBL5431965 IC50 640.0 nM
CCOC(=O)c1sc(Nc2ccc(C)c(F)c2)nc1C1CC1 CHEMBL3410589 IC50 645.0 nM
Cc1cc(C(=O)O)c2[nH]c(-c3ccc(-c4ccc(O)c(O)c4)cc3)nc2c1 CHEMBL3677776 IC50 645.0 nM
CCOC(=O)c1sc(Nc2ccc(C)c(F)c2)nc1C(C)(C)C CHEMBL3410592 IC50 652.0 nM
O=C(O)c1cc(Cl)cc2[nH]c(-c3ccc(-c4ccccc4)cc3F)nc12 CHEMBL3677749 IC50 659.0 nM
O=C(O)c1cc(-c2ccc(Cl)cc2Cl)nc2ccc(Br)cc12 CHEMBL3819188 IC50 666.2 nM
O=C(O)C1=C(C(=O)Nc2ccc(-c3ccccc3)cc2)CSC1 CHEMBL372101 IC50 667.0 nM
Cc1ccccc1NC(=O)c1cccc2nc(-c3cc(Br)nn3-c3ncccc3Cl)[nH]c12 CHEMBL3809369 IC50 676.0 nM
COc1cccc(-c2ccc(NC(=O)C3=C(C(=O)O)C(O)CC3)c(F)c2)c1 CHEMBL194395 IC50 680.0 nM
COc1ccc([C@H]2c3[nH]c4ccccc4c3C[C@@H]3C(=O)N(C4CCCCC4)C(=S)N23)cc1 CHEMBL5289415 EC50 680.0 nM
Cc1cc(C(=O)O)c2nc(-c3ccc(-c4ccc(NC(=O)C5CCCN5)cc4)cc3)[nH]c2c1 CHEMBL3677774 IC50 692.0 nM
CCc1oncc1/C(S)=N/c1ccc(OC(F)(F)F)cc1 CHEMBL306784 IC50 700.0 nM
O=C(Nc1ccccc1C(=O)O)c1ccc(-c2ccccc2)cc1 CHEMBL370865 Ki app 700.0 nM
O=C(Nc1cc(Cl)cc(Cl)c1)Nc1ccccc1C(=O)O CHEMBL1088742 IC50 700.0 nM
COc1cc(-c2cc(C(=O)O)c3ccccc3n2)ccc1OCC(=O)NCc1cccnc1 CHEMBL4862274 IC50 700.0 nM
O=C(O)c1cccc2nc(-c3c(F)c(F)c(-c4ccccc4OCc4ccccc4)c(F)c3F)[nH]c12 CHEMBL3677786 IC50 707.0 nM
CC(C)CCC1=C(O)C(=O)c2ccccc2C1=O CHEMBL155771 IC50 709.0 nM
O=C(/C=C/C=C/c1ccc2c(c1)OCO2)N1CCCCC1 CHEMBL43185 Ki 710.0 nM
O=C(O)c1[nH]c(=O)[nH]c(=O)c1CCc1ccc(C(F)(F)F)cc1 CHEMBL3897952 IC50 719.0 nM
C/C(=C\Cc1c(O)c(Cl)c(C)c(C=O)c1O)CC/C=C(\C)[C@@H]1C[C@H](O)C(C)(C)O1 CHEMBL4865354 IC50 720.0 nM
[2H]C([2H])([2H])Oc1cccc(-c2cc(F)c(NC(=O)C3=C(C(=O)O)COC3)c(F)c2)c1 CHEMBL5402885 IC50 720.0 nM
Cc1c(Nc2nc3ccccc3s2)ccc(Cl)c1CN1CCN(C(=O)C2CCCC2)CC1 CHEMBL5074809 IC50 730.0 nM
O=C(O)C1=C(C(=O)Nc2ccc(-c3ccc(Br)cc3)cc2F)CCC1 CHEMBL345446 IC50 735.0 nM
O=C(O)c1cccc2[nH]c(-c3ccc(-c4ccccc4)cc3)nc12 CHEMBL3593998 IC50 750.0 nM
Cc1cc(C(=O)O)c2nc(-c3ccc(-c4ccc(OCc5cccnc5)cc4)cc3)[nH]c2c1 CHEMBL3677805 IC50 755.0 nM
O=C(Nc1ccc(Oc2ccccc2)cc1)c1c(O)nn2ccccc12 CHEMBL4175712 IC50 760.0 nM
COC(=O)c1cccc(CCc2c(C(=O)O)[nH]c(=O)[nH]c2=O)c1 CHEMBL3898445 IC50 764.0 nM
Oc1ccc(/C=N/c2cccc3ccccc23)c(O)c1 CHEMBL2178107 IC50 780.0 nM
CCOC(=O)c1sc(Nc2ccccc2)nc1-c1ccccc1 CHEMBL3410597 IC50 784.0 nM
Cc1c(Nc2nc3ccccc3s2)cc(Cl)cc1OC1CCN(C(=O)CC(C(F)(F)F)C(F)(F)F)CC1 CHEMBL5082345 IC50 794.0 nM
FC(F)(F)Oc1ccc(NC(=S)c2cnoc2C2CC2)cc1 CHEMBL308141 IC50 800.0 nM
CC(=O)/C(C#N)=C(/S)Nc1ccc(C(F)(F)F)cc1 CHEMBL70544 IC50 800.0 nM
Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 CHEMBL960 IC50 800.0 nM
O=C(O)c1cccc2[nH]c(-c3c(F)c(F)c(-c4ccc(F)cc4)c(F)c3F)nc12 CHEMBL3677818 IC50 808.0 nM
O=C1C(O)=C(Nc2ccccc2Cl)C(=O)c2ccccc21 CHEMBL4452960 IC50 808.0 nM
Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc2c1C(O)C(F)(F)F CHEMBL4793693 IC50 808.0 nM
C/C(=C\c1ccccc1)C(=O)Nc1ccccc1C(=O)O CHEMBL4458679 IC50 814.0 nM
Cc1cc(C(=O)O)c2nc(-c3c(F)c(F)c(-c4cccc(NC(=O)C5CCCN5)c4)c(F)c3F)[nH]c2c1 CHEMBL3677771 IC50 815.0 nM
COC(=O)c1ccc(-n2cc(-c3c(C(=O)O)[nH]c(=O)[nH]c3=O)nn2)cc1 CHEMBL3927463 IC50 839.0 nM
O=C(O)C1=C(C(=O)Nc2ccc(-c3cccc(OC(F)(F)F)c3)cc2C(F)(F)F)CCC1 CHEMBL157004 IC50 840.0 nM
Cc1cc(C(=O)O)c2nc(-c3ccc(-c4cccc(O)c4)cc3)[nH]c2c1 CHEMBL3677801 IC50 862.0 nM
CCOC(=O)c1sc(Nc2ccc3ccccc3c2)nc1C CHEMBL3410581 IC50 887.0 nM
Cc1cc(C(=O)O)c2nc(-c3ccc(-c4cccc(F)c4F)cc3)[nH]c2c1 CHEMBL3677754 IC50 898.0 nM
[2H]C([2H])([2H])Oc1cccc(-c2ccc(NC(=O)C3=C(C(=O)O)CCC3)cc2)c1 CHEMBL5395588 IC50 900.0 nM
O=C(CCNC(=O)c1ccc(C(F)(F)F)cc1)N[C@@H]1CCCc2ccccc21 CHEMBL3184096 IC50 910.0 nM
O=C1C(O)=C(Nc2cccc(Cl)c2)C(=O)c2ccccc21 CHEMBL4457147 IC50 911.0 nM
O=C(O)c1cccc2nc(-c3ccc(-c4ccccc4)cc3F)[nH]c12 CHEMBL3677742 IC50 922.0 nM
CC(=O)c1sc(Nc2ccc(C)c(Cl)c2)nc1C CHEMBL2178108 IC50 930.0 nM
COc1ccc2nc(C(=O)Nc3c(F)cc(-c4cccc(F)c4)cc3F)c(C)c(O)c2c1 CHEMBL3290836 IC50 940.0 nM
O=C(O)c1cc(Cl)cc2[nH]c(-c3ccc(-c4ccccc4F)cc3)nc12 CHEMBL3677750 IC50 949.0 nM
CC(C)Oc1cccc(-c2ccc(NC(=O)C3=C(C(=O)O)CCC3)c(F)c2)c1 CHEMBL5408707 IC50 960.0 nM
O=C([O-])c1c2c(nc3ccc(F)cc13)-c1cccc(Oc3ccccc3)c1CC2 CHEMBL322929 Ki 962.0 nM
O=C(O)c1cccc2nc(-c3ccc(-c4ccccc4F)cc3F)[nH]c12 CHEMBL3677739 IC50 965.0 nM
COc1cccc(CCc2c(C(=O)O)[nH]c(=O)[nH]c2=O)c1 CHEMBL3978933 IC50 968.0 nM
CCOC(=O)c1sc(Nc2ccc(C)c(Cl)c2)nc1C CHEMBL3410580 IC50 969.0 nM
COc1cc(-c2nc3c(C(=O)O)cccc3[nH]2)cc(OC)c1-c1ccccc1 CHEMBL3677737 IC50 975.0 nM
O=C(O)c1cc(Cl)cc2nc(-c3ccc(-c4ccccc4)cc3)[nH]c12 CHEMBL3677747 IC50 994.0 nM