CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C CHEMBL237500 Kd 0.0066 nM
CN(C)C(=O)[C@@H](c1ccc(-c2ccc(F)cc2)cc1)[C@H](N)C(=O)N1CC[C@H](F)C1 CHEMBL237119 IC50 0.012 nM
C[C@H](N)C(=O)N1CCC[C@H]1B(O)O CHEMBL63860 Ki 0.03 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nc3cc(F)ccc3s1)c(=O)n2C CHEMBL4113723 IC50 0.05 nM
C[C@@H](c1ccc(-c2ccc(F)cc2)cc1)[C@H](N)C(=O)N1CC[C@H](F)C1 CHEMBL237336 IC50 0.064 nM
N[C@@H](CCNCc1ccc(Cl)cc1)C(=O)N1CCCCC1 CHEMBL98869 Ki 0.082 nM
CC#CCN1C(N2CCC[C@@H](N)C2)=NC2C1C(=O)N(Cc1cccnc1C#N)C(=O)N2Cc1cccnc1C#N CHEMBL5269668 IC50 0.09 nM
COc1cc(OC)cc(-c2nc(N)c(CN)c(-c3ccc(Cl)cc3Cl)n2)c1 CHEMBL34062 IC50 0.1 nM
COc1cc(OC)cc(-c2nc(-c3ccc(Cl)cc3Cl)c(CN(C)C)c(N(C)C)n2)c1 CHEMBL186877 IC50 0.1 nM
CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O CHEMBL67279 IC50 0.1 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nc3ccccc3s1)c(=O)n2C CHEMBL4111229 IC50 0.1 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1ccc(Cl)cc1C(=O)O)c(=O)n2C CHEMBL4448186 IC50 0.1 nM
N[C@H]1C[C@@H](N2Cc3nn4nccnc4c3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL3806052 IC50 0.12 nM
N#Cc1ccc(N[C@@H]2CN[C@H](C(=O)N3CCC[C@H]3C#N)C2)cc1C#N CHEMBL370046 IC50 0.13 nM
N#Cc1ccc(N[C@@H]2CN[C@H](C(=O)N3CCC[C@H]3C#N)C2)cc1Cl CHEMBL194717 IC50 0.13 nM
N#Cc1ccc(N[C@@H]2CNC(C(=O)N3CCC[C@H]3C#N)C2)cc1C#N CHEMBL456420 IC50 0.13 nM
C=COC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN CHEMBL5220657 IC50 0.13 nM
Cc1cc2ncc3c(n2n1)CN([C@H]1CC[C@H](c2cc(F)c(F)cc2F)[C@@H](N)C1)C3 CHEMBL3805966 IC50 0.14 nM
CCOC(=O)/C=C/OC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C CHEMBL5220613 IC50 0.14 nM
N#Cc1ccc(N[C@@H]2CNC(C(=O)N3CCC[C@H]3C#N)C2)cc1Cl CHEMBL445437 IC50 0.15 nM
C=COC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C CHEMBL5220594 IC50 0.16 nM
NC(=O)c1[nH]nc2c1CN([C@H]1CSC(c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL3644459 IC50 0.17 nM
COc1cc2c3c(ccc2cc1C#N)O[C@H](c1cc(F)c(F)cc1F)[C@@H](N)C3 CHEMBL4550812 Kd 0.177 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](Nc2ccc([N+](=O)[O-])cc2)CN1 CHEMBL370540 IC50 0.18 nM
N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)[C@H]1Cc1ccc(F)cc1)Cc1cc(F)c(F)cc1F CHEMBL1203953 IC50 0.18 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1cc(Cl)ccc1C(=O)O)c(=O)n2C CHEMBL4465482 IC50 0.18 nM
N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)[C@H]1c1ccc(F)cc1)Cc1cc(F)c(F)cc1F CHEMBL5274540 IC5 0.18 nM
N#Cc1ccc(N[C@@H]2CN[C@H](C(=O)N3CCC[C@H]3C#N)C2)cc1 CHEMBL371143 IC50 0.19 nM
NCc1c(N)nc(-c2ccc(F)cc2)nc1-c1ccc(Cl)cc1Cl CHEMBL34842 IC50 0.2 nM
NCc1c(N)nc(-c2cccc(F)c2)nc1-c1ccc(Cl)cc1Cl CHEMBL36666 IC50 0.2 nM
Cc1nc2nc(C(=O)N3CC[C@H](NS(C)(=O)=O)C3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215018 Ki 0.2 nM
O=C([C@@H]1C[C@H](N2CCN(c3nnnn3-c3ccccc3)CC2)CN1)N1CCSC1 CHEMBL2147704 IC50 0.2 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nc3cc(Cl)ccc3s1)c(=O)n2C CHEMBL4109453 IC50 0.2 nM
CS(=O)(=O)c1ccc(-c2noc([C@@H](CC3CC3)[C@H](N)C(F)=C3CCCC3)n2)c(Cl)c1 CHEMBL402163 IC50 0.21 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1ccc(Br)cc1C(=O)O)c(=O)n2C CHEMBL4461587 IC50 0.22 nM
N#Cc1ccc(F)cc1Cn1c(N2CCC[C@@H](N)C2)nc2cc(-c3cccnc3)sc2c1=O CHEMBL5434074 IC50 0.22 nM
Cc1nc2ncc3c(n2n1)CN([C@H]1CC[C@H](c2cc(F)c(F)cc2F)[C@@H](N)C1)C3 CHEMBL3805629 IC50 0.23 nM
N[C@H]1C[C@@H](N2Cc3cnc4nnc(C5CC5)n4c3C2)CC[C@@H]1c1cc(F)c(F)cc1F CHEMBL3806041 IC50 0.24 nM
N#Cc1ccc(N[C@@H]2CN[C@H](C(=O)N3CCC[C@H]3C#N)C2)nc1 CHEMBL195420 IC50 0.25 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)CN(CC(=O)NCc1cccnc1)C2=O CHEMBL1910126 Ki 0.26 nM
O=C([C@@H]1C[C@H](N2CCN(c3nccn3-c3ccccc3)CC2)CN1)N1CCSC1 CHEMBL2147703 IC50 0.26 nM
CC(C)(C)OC(=O)NCC(=O)N1CCC[C@H]1C(=O)O/C=C/c1ccccc1 CHEMBL5219939 IC50 0.26 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2cc(NC(=O)c3cc[nH]n3)ccc2Cl)N1 CHEMBL380350 Ki 0.27 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)CN(CC(=O)N(C)C)C2=O CHEMBL1910117 Ki 0.27 nM
NCCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)O/C=C/c1ccccc1 CHEMBL5220750 IC50 0.27 nM
COc1ccc(N[C@@H]2CN[C@H](C(=O)N3CCC[C@H]3C#N)C2)cc1OC CHEMBL433811 IC50 0.28 nM
C=COC(=O)[C@@H]1CCCN1C(=O)CN CHEMBL5219299 IC50 0.28 nM
NCC(=O)N1CCC[C@H]1C(=O)O/C=C/c1ccccc1 CHEMBL5219451 IC50 0.28 nM
N[C@@H](CC(=O)N1CCCNC(=O)[C@H]1Cc1cnccn1)Cc1cc(F)c(F)cc1F CHEMBL217702 IC50 0.29 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)CN(CC(=O)N1CCC(C(N)=O)CC1)C2=O CHEMBL1910119 Ki 0.29 nM
CC(C)[C@H](Oc1ccc(CNC(=O)[C@@H]2CSCN2C(=O)CC(N)Cc2cc(F)ccc2F)cc1)C(=O)O CHEMBL366290 IC50 0.3 nM
CC(C)[C@@H](N)C(=O)N1CCC[C@H]1B(O)O CHEMBL305170 IC50 0.3 nM
CC(C)[C@H](N)C(=O)N1CCC[C@@H]1B(O)O CHEMBL195189 IC50 0.3 nM
Cc1nc2nc(C(=O)N(C)CCS(C)(=O)=O)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215088 Ki 0.3 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)CN(CC(=O)N1CCCC1)C2=O CHEMBL1910123 Ki 0.3 nM
N=C(N)NCCC[C@H](N)C(=O)N1C[C@@H](O)C[C@H]1B(O)O CHEMBL2063040 IC50 0.3 nM
Cc1cc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)n(-c2cccc(F)c2)n1 CHEMBL2147712 IC50 0.3 nM
CCN(CC)C(=O)CN1Cc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)c2C1=O CHEMBL2441846 Ki 0.3 nM
N[C@H]1C[C@@H](N2Cc3[nH]nc(NS(=O)(=O)c4c[nH]cn4)c3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL3736137 IC50 0.3 nM
N#C[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)[C@@H](N)C12CC3CC(CC(O)(C3)C1)C2 CHEMBL385517 Kd 0.3 nM
CC(C)[C@H](Nc1ccc(CNC(=O)[C@@H]2CSCN2C(=O)C[C@H](N)Cc2cc(F)ccc2F)cc1)C(=O)O CHEMBL5267798 IC50 0.3 nM
N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1Cc1ccccc1C(F)(F)F)Cc1cc(F)c(F)cc1F CHEMBL536090 IC50 0.31 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)CN(CC(=O)N1CCOCC1)C2=O CHEMBL1910124 Ki 0.31 nM
N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1C(O)c1ccc(F)cc1)Cc1cc(F)c(F)cc1F CHEMBL536536 IC50 0.32 nM
O=C([C@@H]1C[C@H](N2CCN(c3cc(C(F)(F)F)nn3-c3ccccc3)CC2)CN1)N1CCSC1 CHEMBL2147709 IC50 0.32 nM
COc1ccc(N[C@@H]2CN[C@H](C(=O)N3CCC[C@H]3C#N)C2)cc1 CHEMBL195063 IC50 0.33 nM
N#Cc1ccccc1Cn1c(N2CCC[C@@H](N)C2)nc2ccsc2c1=O CHEMBL1651766 IC50 0.33 nM
Cn1c(=O)c2c(cc(N3CCC[C@@H](N)C3)n2Cc2cc(F)ccc2C#N)n(C)c1=O CHEMBL1819089 IC50 0.34 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2cc([N+](=O)[O-])c(Cl)cc2Cl)N1 CHEMBL379997 Ki 0.35 nM
C[C@H](N)C(=S)N1CCC[C@H]1B(O)O CHEMBL3686733 IC50 0.35 nM
CNC(=O)CN1Cc2c(nc(C)c(CN)c2-c2ccc(Cl)cc2Cl)C1=O CHEMBL1910116 Ki 0.37 nM
O=C([C@@H]1C[C@H](N2CCN(c3cc(C(F)(F)F)nc4ccccc34)CC2)CN1)N1CCSC1 CHEMBL2058971 IC50 0.37 nM
Cc1cc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)n(-c2ccccc2)n1 CHEMBL2147777 IC50 0.37 nM
CC(C)=CCC/C(C)=C/OC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C CHEMBL5219532 IC50 0.37 nM
CS(=O)(=O)c1cccc(C(=O)NC[C@@H]2CCCN2C(=O)C[C@H](N)Cc2cccc(Cl)c2)c1 CHEMBL564249 IC50 0.38 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1C(=O)N(Cc1nc(C)c3ccccc3n1)C1=NCCN12 CHEMBL3675618 IC50 0.38 nM
Cc1ccc(-c2c(CN)c(CC(C)C)nc3ccc(-c4nc(C(=O)O)cs4)cc23)cc1 CHEMBL4068446 IC50 0.38 nM
N#Cc1ccc2[nH]c(N3CCN([C@@H]4CN[C@H](C(=O)N5CCSC5)C4)CC3)nc2c1 CHEMBL2058762 IC50 0.39 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2ccc(C(=O)O)cc2Br)N1 CHEMBL384445 Ki 0.4 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2cc(C(=O)O)cnc2Cl)N1 CHEMBL377296 Ki 0.4 nM
N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1Cc1ccccn1)Cc1cc(F)c(F)cc1F CHEMBL557176 IC50 0.4 nM
NCC(=O)N1CCC[C@H]1B(O)O CHEMBL67089 Ki 0.4 nM
CCOC(=O)c1cn2c(-c3ccc(Cl)cc3Cl)c(CN)c(C)nc2n1 CHEMBL1214876 Ki 0.4 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)CN(CC(=O)Nc1ccnn1C)C2=O CHEMBL1910125 Ki 0.4 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccc3ccc(Cl)cc3n2)c1=O CHEMBL2425893 IC50 0.4 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(CC(=O)N1CCCC1)C2 CHEMBL2441954 Ki 0.4 nM
CCCN(C)C(=O)CN1Cc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)c2C1=O CHEMBL2441953 Ki 0.4 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(C[C@@H]1CCCN1S(=O)(=O)C1CC1)C2 CHEMBL2441841 Ki 0.4 nM
N[C@H]1C[C@@H](N2Cc3[nH]nc(S(=O)(=O)c4ccccc4)c3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL3735843 IC50 0.4 nM
C[C@H](F)CN1C[C@H](N2Cc3cn(S(C)(=O)=O)nc3C2)C[C@H](N)C1c1cc(F)ccc1F CHEMBL3697942 IC50 0.4 nM
CCC(C)[C@H](N)C(=O)N1CSC[C@H]1C#N CHEMBL93208 Ki 0.41 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2cc(Br)c3c(c2)OCO3)N1 CHEMBL207068 Ki 0.41 nM
N#Cc1ccc2sc(N3CCN([C@@H]4CN[C@H](C(=O)N5CCSC5)C4)CC3)nc2c1 CHEMBL2058758 IC50 0.42 nM
CC(C)=CCn1c(N2CCC[C@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C CHEMBL237067 Kd 0.42 nM
COc1ccc(CC2c3nnc(C(F)(F)F)n3CCN2C(=O)C[C@H](N)Cc2cc(F)c(F)cc2F)cc1 CHEMBL539352 IC50 0.43 nM
CCN(CC)C(=O)CN1Cc2c(nc(C)c(CN)c2-c2ccc(Cl)cc2Cl)C1=O CHEMBL1910118 Ki 0.43 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1cc(OC)ccc1C(=O)O)c(=O)n2C CHEMBL4588692 IC50 0.44 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2ncc(C(=O)O)cc2Cl)N1 CHEMBL379725 Ki 0.45 nM
N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1Cc1ccccc1F)Cc1cc(F)c(F)cc1F CHEMBL540888 IC50 0.46 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)CN(CC(=O)N1CCN(S(C)(=O)=O)CC1)C2=O CHEMBL1910121 Ki 0.46 nM
N#Cc1[nH]nc2c1CN([C@H]1CSC(c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL3644460 IC50 0.46 nM
COC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 CHEMBL5220474 IC50 0.46 nM
CC(C)[C@@H](Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)CC(N)Cc2cc(F)ccc2F)cc1)C(=O)O CHEMBL364102 IC50 0.48 nM
CC(C)[C@H](Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)C[C@H](N)Cc2cc(F)ccc2F)cc1)C(=O)O CHEMBL445949 IC50 0.48 nM
Cn1c(=O)c2c(nc(N3CCC[C@@H](N)C3)n2Cc2cc(F)ccc2Cl)c2ccc(C(=O)O)cc21 CHEMBL2147070 IC50 0.48 nM
CC(C)[C@H](Nc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)C[C@H](N)Cc2cc(F)ccc2F)cc1)C(=O)O CHEMBL5287917 IC50 0.48 nM
CC(C)[C@H](Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)C[C@H](N)Cc2cc(F)ccc2F)cc1)C(=O)O CHEMBL1186023 IC50 0.48 nM
N[C@@H](CC(=O)N1CCCNC(=O)[C@H]1Cc1ccccn1)Cc1cc(F)c(F)cc1F CHEMBL216178 IC50 0.49 nM
N#C[C@@H]1CSCN1C(=O)C(N)C1CCCC1 CHEMBL93060 Ki 0.5 nM
COc1cc2c(cc1OC)[C@@H]1CC(N)[C@@H](c3cccc(CF)c3)CN1CC2 CHEMBL591279 IC50 0.5 nM
Cc1nc2nc(C(=O)N3CCN(S(C)(=O)=O)CC3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215087 Ki 0.5 nM
CC(C)=CCn1c(N2CCC[C@H](N)C2)c(C#N)c2ncn(Cc3nccc4ccccc34)c(=O)c21 CHEMBL1951432 IC50 0.5 nM
COc1cccc(C(=O)Cn2c(=O)c3c(c(C#N)c(N4CCC[C@H](N)C4)n3CC=C(C)C)n(C)c2=O)c1 CHEMBL1951598 IC50 0.5 nM
N#Cc1ccc2oc(N3CCN([C@@H]4CN[C@H](C(=O)N5CCSC5)C4)CC3)nc2c1 CHEMBL2058756 IC50 0.5 nM
COc1cc2c(cc1OC)[C@@H]1C[C@H](N)[C@@H](c3cccc(CF)c3)CN1CC2 CHEMBL1229820 IC50 0.5 nM
N[C@H]1C[C@@H](N2Cc3cnc(C(F)(F)F)nc3C2)CC[C@@H]1c1cc(F)c(F)cc1F CHEMBL2425059 IC50 0.5 nM
Cc1cc(O)n2nc3c(c2n1)CN([C@H]1CO[C@H](c2cc(F)c(F)cc2F)[C@@H](N)C1)C3 CHEMBL3805154 IC50 0.5 nM
Cc1ccn2nc3c(c2n1)CN([C@H]1CO[C@H](c2cc(F)c(F)cc2F)[C@@H](N)C1)C3 CHEMBL3805751 IC50 0.5 nM
CS(=O)(=O)n1cc2c(n1)CN([C@H]1CSC(c3cc(F)cc(F)c3F)[C@@H](N)C1)C2 CHEMBL3644456 IC50 0.5 nM
Cc1c2c(nn1S(=O)(=O)C1(C)CC1)CN([C@H]1CCO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL3654424 IC50 0.5 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c(C)c(=O)n(Cc3nc(C)c4c(F)cccc4n3)c(=O)n21 CHEMBL5278252 IC50 0.5 nM
N#Cc1cnc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)c2ccccc12 CHEMBL2058975 IC50 0.51 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](Nc2ccccc2)CN1 CHEMBL195335 IC50 0.53 nM
N#Cc1ccc(F)cc1Cn1c(N2CCC[C@@H](N)C2)nc2c(-c3cccs3)c[nH]c2c1=O CHEMBL4176578 IC50 0.54 nM
N#Cc1ccc(F)cc1Cn1c(N2CCC[C@@H](N)C2)nc2c(-c3ccc(F)cc3)c[nH]c2c1=O CHEMBL4164470 IC50 0.54 nM
CC(=O)N1CCN(C(=O)CN2Cc3c(nc(C)c(CN)c3-c3ccc(Cl)cc3Cl)C2=O)CC1 CHEMBL1910120 Ki 0.55 nM
O=C([C@@H]1C[C@H](N2CCN(c3nc4ccccc4s3)CC2)CN1)N1CCSC1 CHEMBL2058757 IC50 0.55 nM
Cc1ccc(F)cc1Cn1c(N2CCC[C@@H](N)C2)nc2c3ccc(C(=O)O)cc3n(C)c(=O)c21 CHEMBL2147056 IC50 0.55 nM
Cc1cc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)c2ccccc2n1 CHEMBL2058970 IC50 0.56 nM
Cc1nnc2ncc3c(n12)CN([C@H]1CC[C@H](c2cc(F)c(F)cc2F)[C@@H](N)C1)C3 CHEMBL3806023 IC50 0.56 nM
N#C[C@@H]1CCCN1C(=O)CNC12CC3CC(CC(O)(C3)C1)C2 CHEMBL142703 IC50 0.58 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2ccc(NS(=O)(=O)c3ccccc3)cc2Br)N1 CHEMBL377689 Ki 0.59 nM
O=C([C@@H]1C[C@H](N2CCN(c3nc4cc(Cl)ccc4[nH]3)CC2)CN1)N1CCSC1 CHEMBL2058761 IC50 0.59 nM
N#Cc1ccc(OC[C@H]2CC[C@@H](C(=O)N3CCC[C@H]3C#N)N2)c(Cl)c1 CHEMBL209940 Ki 0.6 nM
CC[C@H](C)[C@H](N)C(=O)N1C[C@@H](F)C[C@H]1C#N CHEMBL461117 IC50 0.6 nM
Cc1nc2nc(C(=O)N3COCC3(C)C)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215164 Ki 0.6 nM
CC[C@@H](C)[C@H](N)C(=O)N1C[C@@H](F)C[C@H]1C#N CHEMBL3632865 IC50 0.6 nM
Cc1cc(O)nc2c3c(nn12)CN([C@H]1CO[C@H](c2cc(F)c(F)cc2F)[C@@H](N)C1)C3 CHEMBL3806310 IC50 0.6 nM
Cc1ccnc2c3c(nn12)CN([C@H]1CO[C@H](c2cc(F)c(F)cc2F)[C@@H](N)C1)C3 CHEMBL3806021 IC50 0.6 nM
Cc1cc2ncc3c(n2n1)CN([C@H]1CC[C@H](c2cc(F)ccc2F)[C@@H](N)C1)C3 CHEMBL3806157 IC50 0.6 nM
CS(=O)(=O)n1cc2c(n1)CN([C@H]1CSC(c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL3644458 IC50 0.6 nM
Oc1ccc(/C=C/c2cc(O)cc(O)c2)cc1 CHEMBL165 IC50 0.6 nM
O=C([C@@H]1C[C@H](N2CCN(c3nccc4ccccc34)CC2)CN1)N1CCSC1 CHEMBL2058973 IC50 0.61 nM
O=C([C@@H]1C[C@H](N2CCN(c3ccnc4cc(Cl)ccc34)CC2)CN1)N1CCSC1 CHEMBL2058972 IC50 0.61 nM
CS(=O)(=O)c1cccc(-c2c[nH]c3c(=O)n(Cc4cc(F)ccc4C#N)c(N4CCC[C@@H](N)C4)nc23)c1 CHEMBL4169845 IC50 0.61 nM
CS(=O)(=O)c1ccc(OC[C@H]2CC[C@@H](C(=O)N3CCC[C@H]3C#N)N2)c(Br)c1 CHEMBL382899 Ki 0.62 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2cc(C(=O)O)ccc2Br)N1 CHEMBL377151 Ki 0.62 nM
Cc1cc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)n(-c2cccnc2)n1 CHEMBL2147773 IC50 0.62 nM
Cc1cc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)n(-c2ccccn2)n1 CHEMBL2147771 IC50 0.63 nM
COCCOc1ccc2nc(C3(NC(=O)C[C@H](N)Cc4cc(Cl)ccc4F)CCS(=O)(=O)CC3)sc2c1 CHEMBL512651 IC50 0.64 nM
N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1Cc1ccccc1)Cc1cc(F)c(F)cc1F CHEMBL539350 IC50 0.66 nM
N[C@H]1C[C@@H](N2Cc3cnc(C4CC4)nc3C2)CO[C@@H]1c1cc(F)c(F)cc1F CHEMBL2425061 IC50 0.66 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2cc(C(=O)O)ccc2Cl)N1 CHEMBL378867 Ki 0.67 nM
N[C@H]1C[C@@H](N2Cc3cncnc3C2)CC[C@@H]1c1cc(F)c(F)cc1F CHEMBL233564 IC50 0.67 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)CN(CC(=O)N1CCN(C)CC1)C2=O CHEMBL1910122 Ki 0.67 nM
Cc1nc2nc(C(=O)N(C)CCc3ccccn3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215236 Ki 0.7 nM
C[C@H](NC(=O)CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1B(O)O CHEMBL1765236 IC50 0.7 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccc3ccc(F)cc3n2)c1=O CHEMBL2425894 IC50 0.7 nM
CC(C)S(=O)(=O)n1cc2c(n1)CN([C@H]1CO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL3735865 IC50 0.7 nM
N[C@H]1C[C@@H](N2Cc3nn4cccnc4c3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL3806216 IC50 0.7 nM
Cc1cc2ncc3c(n2n1)CN([C@H]1CO[C@H](c2cc(F)c(F)cc2F)[C@@H](N)C1)C3 CHEMBL3806029 IC50 0.7 nM
Cc1cc2ncc3c(n2n1)CN([C@H]1CO[C@H](c2cc(F)ccc2F)[C@@H](N)C1)C3 CHEMBL3805294 IC50 0.7 nM
N[C@H]1C[C@@H](N2Cc3cn(S(=O)(=O)C4CC4)nc3C2)CNC1c1cc(F)c(F)cc1F CHEMBL3694422 IC50 0.7 nM
N[C@H]1C[C@@H](N2Cc3cnc(C(F)(F)F)nc3C2)CSC1c1cc(F)ccc1F CHEMBL3639433 IC50 0.7 nM
N[C@H]1C[C@@H](N2Cc3nc(-c4ccccc4)[nH]c3C2)CSC1c1cc(F)ccc1F CHEMBL3644462 IC50 0.7 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c(C)c(=O)n(Cc3nc(C)c4c(Cl)cccc4n3)c(=O)n21 CHEMBL5278621 IC50 0.7 nM
CS(=O)(=O)n1ncc2c1CN([C@H]1CO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL5279910 IC50 0.7 nM
N[C@H]1C[C@@H](N2Cc3cnn(S(=O)(=O)C(F)(F)F)c3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL5268418 IC50 0.7 nM
CCS(=O)(=O)n1ncc2c1CN([C@H]1CO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL5273218 IC50 0.7 nM
CCCS(=O)(=O)n1ncc2c1CN([C@H]1CO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL5275162 IC50 0.7 nM
CC(C)S(=O)(=O)n1ncc2c1CN([C@H]1CO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL5277064 IC50 0.7 nM
N[C@H]1C[C@@H](N2Cc3cnn(S(=O)(=O)C4CC4)c3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL3736190 IC50 0.7 nM
N[C@H]1C[C@@H](N2Cc3cnn(S(=O)(=O)C4CCCC4)c3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL3645492 IC50 0.7 nM
Cn1ccnc1S(=O)(=O)n1ncc2c1CN([C@H]1CO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL5267753 IC50 0.7 nM
N[C@H]1C[C@@H](N2Cc3cnn(S(=O)(=O)c4ccccc4)c3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL5283277 IC50 0.7 nM
N[C@H]1C[C@@H](N2Cc3cnn(S(=O)(=O)c4ccc(C(F)(F)F)cc4)c3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL5276887 IC50 0.7 nM
N[C@H]1C[C@@H](N2Cc3cn(S(=O)(=O)C4CC4)nc3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL3735329 IC50 0.7 nM
N[C@H]1C[C@@H](N2Cc3cn(S(=O)(=O)C4CCCC4)nc3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL3736085 IC50 0.7 nM
Cn1cnc(S(=O)(=O)n2cc3c(n2)CN([C@H]2CO[C@H](c4cc(F)ccc4F)[C@@H](N)C2)C3)c1 CHEMBL3736423 IC50 0.7 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2cccnc2Cl)N1 CHEMBL378010 Ki 0.72 nM
CS(=O)(=O)c1ccc(-c2c[nH]c3c(=O)n(Cc4cc(F)ccc4C#N)c(N4CCC[C@@H](N)C4)nc23)cc1 CHEMBL4175111 IC50 0.72 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1cc(Br)ccc1C(=O)O)c(=O)n2C CHEMBL4536341 IC50 0.72 nM
O=C([C@@H]1C[C@H](N2CCN(c3ncc(Cl)c4ccccc34)CC2)CN1)N1CCSC1 CHEMBL2058974 IC50 0.73 nM
CCOC(=O)N1CCN(c2ccc3nnc(-c4cccc(C)c4)n3n2)CC1 CHEMBL4454091 IC50 0.75 nM
C/C=C/OC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN CHEMBL5218500 IC50 0.75 nM
N#Cc1ccc(F)cc1Cn1c(N2CCC[C@@H](N)C2)nc2c(-c3ccsc3)c[nH]c2c1=O CHEMBL4165967 IC50 0.76 nM
O=[N+]([O-])c1cccc(/C=N/N2C(c3ccccc3)=Nc3ccc(I)cc3C2Nc2nccs2)c1 CHEMBL4239107 IC50 0.76 nM
O=[N+]([O-])c1cccc(/C=N/N2C(c3ccccc3)=Nc3ccc(I)cc3C2NC2NC=CS2)c1 CHEMBL4638480 IC50 0.76 nM
N#Cc1ccc(F)cc1Cn1c(N2CCC[C@@H](N)C2)nc2c(F)c[nH]c2c1=O CHEMBL4172793 IC50 0.77 nM
CS(=O)(=O)c1ccc(-c2c[nH]c3c(=O)n(Cc4cc(F)ccc4C#N)c(N4CCC[C@@H](N)C4)nc23)c(F)c1 CHEMBL4162971 IC50 0.77 nM
N[C@@H](CC(=O)NC1(c2nc3ccc(OCCN4CCOCC4)cc3s2)CCS(=O)(=O)CC1)Cc1cc(F)c(F)cc1F CHEMBL504021 IC50 0.79 nM
N#Cc1ccc(F)cc1Cn1c(N2CCC[C@@H](N)C2)nc2c(Br)c[nH]c2c1=O CHEMBL4169403 IC50 0.79 nM
N#C[C@@H]1CSCN1C(=O)C(N)C1CCCCC1 CHEMBL316560 Ki 0.8 nM
C[C@@H](N)C(=O)N1CCC[C@H]1B(O)O CHEMBL196120 IC50 0.8 nM
O=C([C@@H]1C[C@H](N2CCN(c3nc4ccccc4[nH]3)CC2)CN1)N1CCSC1 CHEMBL2058760 IC50 0.8 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(CC(=O)N1CCCCC1)C2 CHEMBL2441955 Ki 0.8 nM
CS(=O)(=O)n1cc2c(n1)CN([C@H]1CO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL2105762 Ki 0.8 nM
CC[C@@H](C)[C@H](N)C(=O)N1CC(F)(F)C[C@H]1C#N CHEMBL3632867 IC50 0.8 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccc(Br)c(C(=O)O)c2)c1=O CHEMBL4856337 IC50 0.8 nM
NC[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2cc(C(=O)O)ccc2Cl)N1 CHEMBL1230804 Ki 0.82 nM
CC(C)[C@@H](Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)CC(N)Cc2ccc(C(F)(F)F)cc2F)cc1)C(=O)O CHEMBL364140 IC50 0.83 nM
CS(=O)(=O)c1ccc(OC[C@H]2CC[C@@H](C(=O)N3CCC[C@H]3C#N)N2)c(Cl)c1 CHEMBL210805 Ki 0.83 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2ccccc2Cl)N1 CHEMBL377390 Ki 0.85 nM
Cc1cc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)n(-c2ccccc2F)n1 CHEMBL2147713 IC50 0.85 nM
N#Cc1ccccc1Cn1c(N2CCC[C@@H](N)C2)nc2sccc2c1=O CHEMBL1651763 IC50 0.87 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNC(=O)c1cccnc1)[C@H]1CCc2cc(F)c(F)cc21 CHEMBL5274129 IC50 0.87 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNC(=O)c1cccc(S(N)(=O)=O)c1)[C@H]1CCc2cc(F)c(F)cc21 CHEMBL5276657 IC50 0.87 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNC(=O)c1ccc(F)c(S(N)(=O)=O)c1)[C@H]1CCc2cc(F)c(F)cc21 CHEMBL5265910 IC50 0.87 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNC(=O)c1cc(S(N)(=O)=O)c(F)cc1F)[C@H]1CCc2cc(F)c(F)cc21 CHEMBL5269746 IC50 0.87 nM
CCN(CC)S(=O)(=O)c1cccc(C(=O)NC[C@@H]2CCCN2C(=O)C[C@H](N)[C@H]2CCc3cc(F)c(F)cc32)c1 CHEMBL5277828 IC50 0.87 nM
CCN(CC)S(=O)(=O)c1cc(C(=O)NC[C@@H]2CCCN2C(=O)C[C@H](N)[C@H]2CCc3cc(F)c(F)cc32)ccc1F CHEMBL5269884 IC50 0.87 nM
CCN(CC)S(=O)(=O)c1cc(C(=O)NC[C@@H]2CCCN2C(=O)C[C@H](N)[C@H]2CCc3cc(F)c(F)cc32)c(F)cc1F CHEMBL5273793 IC50 0.87 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNC(=O)c1cc(S(=O)(=O)N2CCCCC2)c(F)cc1F)[C@H]1CCc2cc(F)c(F)cc21 CHEMBL5276298 IC50 0.87 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNC(=O)c1cc(S(=O)(=O)N2CCOCC2)c(F)cc1F)[C@H]1CCc2cc(F)c(F)cc21 CHEMBL5289339 IC50 0.87 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNC(=O)c1cc(S(=O)(=O)N2CCC2)c(F)cc1F)[C@H]1CCc2cc(F)c(F)cc21 CHEMBL5279474 IC50 0.87 nM
N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F CHEMBL1422 IC50 0.87 nM
CC(C)[C@H](N)C(=O)N[C@@H](C)B(O)O CHEMBL365322 IC50 0.89 nM
Cc1cccc(-c2nc(N)c(CN)c(-c3ccc(Cl)cc3Cl)n2)c1 CHEMBL35116 IC50 0.9 nM
N#C[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)[C@@H](N)C12CC3CC(CC(C3)C1)C2 CHEMBL3350935 Ki 0.9 nM
Cc1cc(NC(=O)c2cn3c(-c4ccc(Cl)cc4Cl)c(CN)c(C)nc3n2)n(C)n1 CHEMBL1215089 Ki 0.9 nM
Cc1nc2nc(C(=O)N(C)Cc3ccco3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215301 Ki 0.9 nM
CC(C)(C)OC[C@@H]1C(=O)NCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL1779710 IC50 0.9 nM
CN1C[C@H](N2Cc3cn(S(C)(=O)=O)nc3C2)C[C@H](N)C1c1cc(F)c(F)cc1F CHEMBL3697938 IC50 0.9 nM
N[C@@H](CC(=O)N1CCCNC(=O)[C@H]1Cc1ccccc1)Cc1cc(F)c(F)cc1F CHEMBL386380 IC50 0.91 nM
O=C([C@@H]1C[C@H](N2CCN(c3ccc([N+](=O)[O-])cn3)CC2)CN1)N1CCSC1 CHEMBL399610 IC50 0.92 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2ccc(C(=O)O)cc2Cl)N1 CHEMBL379999 Ki 0.93 nM
O=C([C@@H]1C[C@H](N2CCN(c3ccnn3-c3ccccc3)CC2)CN1)N1CCSC1 CHEMBL2147707 IC50 0.94 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(CC(=O)N(C)C)C2 CHEMBL2441952 Ki 0.94 nM
O=C([C@@H]1C[C@H](N2CCN(c3ccnc4ccccc34)CC2)CN1)N1CCSC1 CHEMBL2058969 IC50 0.95 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2ccc(C(=O)O)c3ccccc23)N1 CHEMBL380090 Ki 0.96 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2cc(C(=O)O)c[n+]([O-])c2Cl)N1 CHEMBL382700 Ki 0.98 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)C1CCCC1 CHEMBL94278 Ki 1.0 nM
C#C[C@H]1CC[C@@H](C#N)N1C(=O)CNC1(C)CCN(c2cc(C(=O)O)ccn2)CC1 CHEMBL386369 Ki 1.0 nM
CC1(NCC(=O)N2CCC[C@H]2C#N)CCN(c2cc(C(=O)O)ccn2)CC1 CHEMBL217455 Ki 1.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1OCC(=O)NC)c(=O)n2C CHEMBL237289 IC50 1.0 nM
NC1CN(c2cc(-c3cccc(C(=O)O)c3)ncn2)CC1c1cc(F)c(F)cc1F CHEMBL245585 Ki 1.0 nM
N#Cc1ccc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)nc1 CHEMBL241253 IC50 1.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2cnn(Cc3nc(C)c4ccccc4n3)c(=O)c21 CHEMBL403553 IC50 1.0 nM
CC#CCn1c(NCCN)nc2cnn(Cc3nc(C)c4ccccc4n3)c(=O)c21 CHEMBL257376 IC50 1.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c(C)nn(Cc3nc(C)c4ccccc4n3)c(=O)c21 CHEMBL256121 IC50 1.0 nM
COCCOc1ccc2nc(C3(NC(=O)C[C@H](N)Cc4cc(F)c(F)cc4F)CCS(=O)(=O)CC3)sc2c1 CHEMBL471834 IC50 1.0 nM
N#Cc1c(F)cc(N2CCC(NCC(=O)N3C[C@@H](F)C[C@H]3C#N)CC2)cc1F CHEMBL480903 Ki 1.0 nM
CS(=O)(=O)N1CC(c2noc([C@@H]3CCCN3C(=O)C[C@H](N)Cc3cc(F)c(F)cc3F)n2)C1 CHEMBL566425 IC50 1.0 nM
Cc1nc2nc(C(=O)N3CCNC(=O)C3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215016 Ki 1.0 nM
CC(C)[C@@H](Nc1ccc(CNC(=O)[C@@H]2SCCN2C(=O)C[C@H](N)Cc2cc(F)c(F)cc2F)cc1)C(=O)O CHEMBL1683506 IC50 1.0 nM
Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O CHEMBL376359 IC50 1.0 nM
COc1cccc(C(=O)Cn2cnc3c(C#N)c(N4CCC[C@H](N)C4)n(CC=C(C)C)c3c2=O)c1 CHEMBL1951430 IC50 1.0 nM
CC(C)=CCn1c(N2CCC[C@H](N)C2)c(C#N)c2c1c(=O)n(Cc1nccc3ccccc13)c(=O)n2C CHEMBL1951599 IC50 1.0 nM
CC(C)=CCn1c(N2CCCNCC2)c(C#N)c2c1c(=O)n(Cc1ncc3ccccc3c1C#N)c(=O)n2C CHEMBL1951611 IC50 1.0 nM
CC#CCn1c(N2CCCNCC2)c(C#N)c2c1c(=O)n(Cc1ncc3ccccc3c1C#N)c(=O)n2C CHEMBL1951416 IC50 1.0 nM
CC(C)=CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C CHEMBL237488 IC50 1.0 nM
N[C@H]1C[C@@H](N2Cc3cn[nH]c3C2)CO[C@@H]1c1cc(F)c(F)cc1F CHEMBL2425075 IC50 1.0 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(CCC(=O)O)C2 CHEMBL2441845 Ki 1.0 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(C[C@@H]1CCCO1)C2 CHEMBL2441839 Ki 1.0 nM
N#CC1CCCN1C(=O)CNCC(O)COc1ccccc1 CHEMBL3704833 IC50 1.0 nM
N[C@H]1C[C@@H](N2Cc3cn(S(=O)(=O)C4CC4)nc3C2)COC1c1cc(F)ccc1F CHEMBL3645497 IC50 1.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1C(=O)N(Cc1nc(C)c3ccccc3n1)C1=N[C@@H](C)CN12 CHEMBL3675637 IC50 1.0 nM
N[C@H]1C[C@@H](N2Cc3cn[nH]c3C2)CN(CC(=O)N2CC[C@@H](F)C2)C1c1cc(F)ccc1F CHEMBL3694424 IC50 1.0 nM
N[C@H](C(=O)N1CCC[C@H]1B(O)O)C1CCCCC1 CHEMBL3686737 IC50 1.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1ncc3ccccc3n1)c(=O)n2C CHEMBL3903110 IC50 1.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1ncc(C)c3ccccc13)c(=O)n2C CHEMBL3903787 IC50 1.0 nM
C/C=C/Cn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1OCC(=O)NC)c(=O)n2C CHEMBL3965981 IC50 1.0 nM
C/C=C/Cn1c(N2CCC[C@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1OCC(=O)NC)c(=O)n2C CHEMBL3893759 IC50 1.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccc(F)c(C(=O)O)c2)c1=O CHEMBL4863102 IC50 1.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccc(Cl)c(C(=O)O)c2)c1=O CHEMBL4865204 IC50 1.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1c(Br)cccc1C(=O)O)c(=O)n2C CHEMBL4544024 IC50 1.05 nM
CS(=O)(=O)c1cccc(C(=O)NC[C@@H]2CCCN2C(=O)C[C@H](N)[C@H]2CCc3cc(F)c(F)cc32)c1 CHEMBL5272644 IC50 1.06 nM
N#C[C@@H]1CCCN1C(=O)C(N)C1CCCC1 CHEMBL16834 Ki 1.1 nM
Cc1cc(CN2C[C@H](N)[C@H](C(=O)C3CCC[C@H]3C#N)C2)cc(C)c1C#N CHEMBL399791 IC50 1.1 nM
N#Cc1ccc(NCCNCC(=O)N2C[C@@H](F)C[C@H]2C#N)nc1 CHEMBL1744354 IC50 1.1 nM
CN(C[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F)C(=O)C1CC1 CHEMBL564105 IC50 1.1 nM
CCn1nccc1NC(=O)c1cn2c(-c3ccc(Cl)cc3Cl)c(CN)c(C)nc2n1 CHEMBL1215233 Ki 1.1 nM
COC(=O)[C@@H]1CCCN1C(=O)Cc1c(C)nc(CC(C)C)c(CN)c1-c1ccc(C)cc1 CHEMBL3216064 IC50 1.1 nM
Cc1ccc(-c2c(CC(=O)N3CCC[C@H]3C(N)=O)c(C)nc(CC(C)C)c2CN)cc1 CHEMBL3216725 IC50 1.1 nM
Cc1ccc(-c2c(CN)c(CC(C)C)nc3ccc(N4CC(=O)NCC4=O)cc23)cc1 CHEMBL3142227 IC50 1.1 nM
Cn1c(=O)c2c(cc(N3CCC[C@@](C)(N)C3)n2Cc2cc(F)ccc2C#N)n(C)c1=O CHEMBL1819090 IC50 1.1 nM
CCS(=O)(=O)Nc1n[nH]c2c1CN([C@H]1CO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL3734828 IC50 1.1 nM
N[C@H]1C[C@@H](N2Cc3nn4c(C(F)(F)F)ccnc4c3C2)CC[C@@H]1c1cc(F)c(F)cc1F CHEMBL3805179 IC50 1.1 nM
N[C@H]1C[C@@H](N2Cc3nn4ccc(C(F)(F)F)nc4c3C2)CC[C@@H]1c1cc(F)c(F)cc1F CHEMBL3805871 IC50 1.1 nM
Cc1cc2nc3c(cn2n1)CN([C@H]1CC[C@H](c2cc(F)ccc2F)[C@@H](N)C1)C3 CHEMBL3805226 IC50 1.1 nM
N[C@H]1C[C@@H](N2Cc3nc(C(F)(F)F)[nH]c3C2)CSC1c1cc(F)ccc1F CHEMBL3644461 IC50 1.1 nM
O=C([C@@H]1CCCN1)N1CCC[C@H]1B(O)O CHEMBL63895 IC50 1.1 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccc(Cl)c(C(=O)OC)c2)c1=O CHEMBL4845890 IC50 1.1 nM
CN1CCN(S(=O)(=O)c2cccc(C(=O)NC[C@@H]3CCCN3C(=O)C[C@H](N)[C@H]3CCc4cc(F)c(F)cc43)c2)CC1 CHEMBL5275046 IC50 1.1 nM
Cc1ccc2nc(CNc3nc(C)cs3)n(/N=C/c3ccc(O)cc3)c(=O)c2c1 CHEMBL4247480 IC50 1.12 nM
Cc1ccc2cc(CNc3nc(C)cs3)n(/N=C/c3ccc(O)cc3)c(=O)c2c1 CHEMBL5288974 IC50 1.12 nM
CCOC(=O)/C=C/OC(=O)[C@@H]1CCCN1C(=O)CN CHEMBL5219735 IC50 1.17 nM
N[C@H]1CN(c2ccc3nc(=O)ccn3n2)CC[C@@H]1c1cc(F)c(F)cc1F CHEMBL231396 IC50 1.2 nM
N#Cc1cccnc1N1CCN([C@@H]2CN[C@H](C(=O)N3CCSC3)C2)CC1 CHEMBL241464 IC50 1.2 nM
COc1cc2c(cc1OC)[C@@H]1CC(N)[C@@H](c3cc(CF)ccn3)CN1CC2 CHEMBL598470 IC50 1.2 nM
CC(C)[C@H](Nc1ccc(CNC(=O)[C@@H]2SCCN2C(=O)C[C@H](N)Cc2cc(F)c(F)cc2F)cc1)C(=O)O CHEMBL1683508 IC50 1.2 nM
O=C([C@@H]1C[C@H](N2CCN(c3nc4ccccc4o3)CC2)CN1)N1CCSC1 CHEMBL2058967 IC50 1.2 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2cc(Cl)c3ccccc3n2)c1=O CHEMBL2425895 IC50 1.2 nM
N=C(N)NCCC[C@H](N)C(=S)N1CCC[C@H]1B(O)O CHEMBL3686750 IC50 1.2 nM
CC#CC(CC(=O)O)c1ccc(OCc2cccc(CN3CCC4N=C(C5CC5)OC4C3)c2)cc1 CHEMBL4632639 EC50 1.2 nM
Cc1csc(NC2c3cc(I)ccc3N=C(c3ccccc3)N2/N=C/c2cccc([N+](=O)[O-])c2)n1 CHEMBL4238698 IC50 1.22 nM
N#Cc1ccc(F)cc1Cn1c(N2CCC[C@@H](N)C2)nc2c(F)c(F)[nH]c2c1=O CHEMBL4164893 IC50 1.25 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1C(=O)N(Cc1nc(C)c3ccccc3n1)C1=NCCCN12 CHEMBL3675622 IC50 1.28 nM
C#C[C@H]1CC[C@@H](C#N)N1C(=O)CNC1(C)CCN(c2ccc(C(=O)O)cn2)CC1 CHEMBL216957 Ki 1.3 nM
N[C@H]1CC(C(=O)N2CCn3c(nnc3C(F)(F)F)C2)=CC[C@@H]1c1cc(F)c(F)c(F)c1 CHEMBL437341 Ki 1.3 nM
CS(=O)(=O)c1cccc(-c2ncnc(N3CC(N)C(c4cc(F)c(F)cc4F)C3)n2)c1 CHEMBL246530 Ki 1.3 nM
N#Cc1ccc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)cc1C#N CHEMBL238515 IC50 1.3 nM
Cc1cc(CN2C[C@H](N)[C@H](C(=O)C3CCC[C@H]3C#N)C2)ccc1C#N CHEMBL429115 IC50 1.3 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNC(=O)C1CC1(F)F)Cc1cc(F)c(F)cc1F CHEMBL554908 IC50 1.3 nM
Cc1nc2nc(C(=O)NCCc3ccncc3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215448 Ki 1.3 nM
CC(C)(C)SC[C@@H]1C(=O)NCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL1779714 IC50 1.3 nM
N[C@H]1C[C@@H](N2Cc3cnc(C(F)(F)F)nc3C2)CO[C@@H]1c1cc(F)c(F)cc1F CHEMBL2425060 IC50 1.3 nM
N[C@H]1C[C@@H](N2Cc3[nH]nc(NS(=O)(=O)CC(F)(F)F)c3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL3735461 IC50 1.3 nM
N[C@H]1C[C@@H](N2Cc3cn(S(=O)(=O)C4CCCC4)nc3C2)COC1c1cc(F)c(F)cc1F CHEMBL3645494 IC50 1.3 nM
Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2cc(F)ccc2C#N)c1=O CHEMBL1650443 IC50 1.3 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccc(Br)c(C(=O)OC)c2)c1=O CHEMBL4851477 IC50 1.3 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2cc(Br)cc(C(=O)OC)c2)c1=O CHEMBL4863369 IC50 1.3 nM
Cc1csc2nc(N3CCC[C@@H](N)C3)n(Cc3ccccc3C#N)c(=O)c12 CHEMBL1651764 IC50 1.32 nM
O=[N+]([O-])c1cccc(/C=N/N2C(c3ccccc3)=Nc3ccccc3C2Nc2nccs2)c1 CHEMBL4249193 IC50 1.33 nM
C#CCn1c(N2CCC[C@H](N)C2)nc2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C CHEMBL5277490 IC50 1.33 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)C1CCCCC1 CHEMBL307636 Ki 1.4 nM
C=CC1([C@H](N)C(=O)N2[C@H](C#N)C[C@@H]3C[C@@H]32)CCCCC1 CHEMBL3350934 Ki 1.4 nM
N#Cc1ccc(NCCNCC(=O)N2CCC[C@H]2C#N)nc1 CHEMBL77538 IC50 1.4 nM
CS(=O)(=O)c1ccc(-c2nc3c(s2)CCN(C(=O)C[C@H](N)Cc2cc(F)ccc2F)C3)cc1 CHEMBL196881 IC50 1.4 nM
Cc1nc2nc(C(=O)NCCc3ccccn3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215376 Ki 1.4 nM
N#Cc1ccccc1Cn1c(N2CCC[C@@H](N)C2)nc2c(Br)c[nH]c2c1=O CHEMBL2023067 IC50 1.4 nM
N[C@H]1C[C@@H](N2Cc3cn[nH]c3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL2425070 IC50 1.4 nM
Cc1oc(=O)oc1COC(=O)c1ccc2c3nc(N4CCC[C@@H](N)C4)n(Cc4ccccc4Cl)c3c(=O)n(C)c2c1 CHEMBL3400965 IC50 1.4 nM
CCC(=O)Nc1n[nH]c2c1CN([C@H]1CO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL3736135 IC50 1.4 nM
N[C@H]1C[C@@H](N2Cc3nn4c(C(F)(F)F)ccnc4c3C2)CO[C@@H]1c1cc(F)c(F)cc1F CHEMBL3805937 IC50 1.4 nM
CS(=O)(=O)c1ccc(-c2c[nH]c3c(=O)n(Cc4cc(F)ccc4C#N)c(N4CCC[C@@H](N)C4)nc23)cc1F CHEMBL4173673 IC50 1.45 nM
Cc1ccccc1C[C@@H]1C(=O)N[C@H](C)CCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL394837 IC50 1.49 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](NC(=O)Nc2ccccc2)CN1 CHEMBL371585 IC50 1.5 nM
C[C@@H](C1CCC(c2cccc3ncnn23)CC1)[C@H](N)C(=O)N1CCC(F)(F)C1 CHEMBL237152 IC50 1.5 nM
O=C([C@@H]1C[C@H](N2CCN(c3ccc(C(F)(F)F)cn3)CC2)CN1)N1CCSC1 CHEMBL241252 IC50 1.5 nM
C=CCC1c2nnc(C(F)(F)F)n2CCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL537000 IC50 1.5 nM
CC(C)(CNC(=O)c1ccc2[nH]nnc2c1)NCC(=O)N1C[C@@H](F)C[C@H]1C#N CHEMBL487860 IC50 1.5 nM
CN(C[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F)S(=O)(=O)C(F)(F)F CHEMBL558452 IC50 1.5 nM
Cc1nc2nc(C(=O)NCCc3cccnc3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215375 Ki 1.5 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)CN(CC(N)=O)C2=O CHEMBL1910115 Ki 1.5 nM
COc1cccc(C(=O)Cn2c(=O)c3c(c(C#N)c(N4CCC[C@H](N)C4)n3Cc3ccccc3)n(C)c2=O)c1 CHEMBL1951595 IC50 1.5 nM
CC[C@@H](C)[C@H](N)C(=O)N1CCC[C@H]1C#N CHEMBL3632864 IC50 1.5 nM
N[C@H]1C[C@@H](N2Cc3nn4ccc(C(F)(F)F)nc4c3C2)CO[C@@H]1c1cc(F)c(F)cc1F CHEMBL3805502 IC50 1.5 nM
Cc1ccn2nc3c(c2n1)CN([C@H]1CO[C@H](c2cc(F)ccc2F)[C@@H](N)C1)C3 CHEMBL3805400 IC50 1.5 nM
Cc1nc2c([nH]1)CN([C@H]1CSC(c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL3644464 IC50 1.5 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2ccn(Cc3nc(C)c4ccccc4n3)c2c1=O CHEMBL2347039 IC50 1.55 nM
CS(=O)(=O)c1ccccc1-c1c[nH]c2c(=O)n(Cc3cc(F)ccc3C#N)c(N3CCC[C@@H](N)C3)nc12 CHEMBL4161924 IC50 1.58 nM
CC(C)[C@@H](Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)CC(N)Cc2cc(F)c(F)cc2F)cc1)C(=O)O CHEMBL364103 IC50 1.6 nM
CC(C)[C@@H](Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)CC(N)Cc2cc(Cl)ccc2F)cc1)C(=O)O CHEMBL184527 IC50 1.6 nM
COc1cc(C(=O)O)ccc1OC[C@H]1CC[C@@H](C(=O)N2CCC[C@H]2C#N)N1 CHEMBL208751 Ki 1.6 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2ccc(Cl)cc2Cl)N1 CHEMBL209941 Ki 1.6 nM
N[C@H]1CN(c2cc(N3CCC(F)(F)C3)ncn2)C(=O)C[C@@H]1c1cc(F)c(F)cc1F CHEMBL434740 Ki 1.6 nM
N#Cc1ccnc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)c1 CHEMBL399405 IC50 1.6 nM
O=C([C@@H]1C[C@H](N2CCN(c3ccc([N+](=O)[O-])cc3)CC2)CN1)N1CCSC1 CHEMBL391466 IC50 1.6 nM
N[C@H]1CN(c2cc(N3CCc4nocc4C3)ncn2)C[C@@H]1c1ccccc1 CHEMBL1683560 IC50 1.6 nM
O=C([C@@H]1C[C@H](N2CCN(c3ccnc4cc(C(F)(F)F)ccc34)CC2)CN1)N1CCSC1 CHEMBL2058759 IC50 1.6 nM
Cn1c(=O)c2c(nc(N3CCC[C@@H](N)C3)n2Cc2ccccc2Cl)c2ccc(C(=O)O)cc21 CHEMBL2147073 IC50 1.6 nM
CC(C)=CCn1c(N2CC3CCCNC3C2)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C CHEMBL2408771 IC50 1.6 nM
N[C@H]1C[C@@H](N2Cc3nc(C(F)(F)F)[nH]c3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL2425069 IC50 1.6 nM
N[C@H]1C[C@@H](N2Cc3[nH]nc(NC(=O)C4CC4)c3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL3734964 IC50 1.6 nM
N[C@H]1C[C@@H](N2Cc3cn(S(=O)(=O)C4CCCC4)nc3C2)COC1c1cc(F)ccc1F CHEMBL3645493 IC50 1.6 nM
N[C@H]1C[C@@H](N2Cc3cnn(S(=O)(=O)C4CC4)c3C2)COC1c1cc(F)ccc1F CHEMBL3645495 IC50 1.6 nM
CC(C)=CCn1c(N2CCC[C@@H](N)C2)nc2c1C(=O)N(Cc1nc(C)c3ccccc3n1)C1=NCCN12 CHEMBL3675624 IC50 1.6 nM
CS(=O)(=O)n1cc2c(n1)CN([C@@H]1C[C@H](N)C(c3cc(F)ccc3F)N(CC3CC3)C1)C2 CHEMBL3697941 IC50 1.6 nM
CC(C)(F)Cn1cc2c(n1)CN([C@H]1CSC(c3cc(F)cc(F)c3F)[C@@H](N)C1)C2 CHEMBL3644457 IC50 1.6 nM
CCC[C@H](N)C(=S)N1CCC[C@H]1B(O)O CHEMBL3686746 IC50 1.6 nM
N[C@@H](Cc1c[nH]c2ccccc12)C(=S)N1CCC[C@H]1B(O)O CHEMBL3686748 IC50 1.6 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccc(F)c(C(=O)OC)c2)c1=O CHEMBL4846335 IC50 1.6 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccc(Cl)c(C(=O)N(C)C)c2)c1=O CHEMBL5279728 IC50 1.6 nM
N#Cc1ccc(F)cc1Cn1c(N2CCC[C@@H](N)C2)nc2c(-c3ccc(S(N)(=O)=O)cc3)c[nH]c2c1=O CHEMBL4173272 IC50 1.61 nM
COc1ccc(/C=N/N2C(c3ccccc3)=Nc3ccc(I)cc3C2Nc2nccs2)cc1 CHEMBL4242883 IC50 1.62 nM
N#Cc1ccc(F)cc1Cn1c(N2CCC[C@@H](N)C2)nc2c(Br)c(Br)[nH]c2c1=O CHEMBL4161474 IC50 1.67 nM
CC(C)S(=O)(=O)c1ccc(-c2c[nH]c3c(=O)n(Cc4cc(F)ccc4C#N)c(N4CCC[C@@H](N)C4)nc23)cc1 CHEMBL4165359 IC50 1.69 nM
CCC(C)[C@H](N)C(=O)N1CCS[C@H]1C#N CHEMBL327187 Ki 1.7 nM
CC(C)[C@@H](Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)CC(N)Cc2ccc(F)cc2Cl)cc1)C(=O)O CHEMBL366048 IC50 1.7 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](C(=O)N2Cc3ccccc3C2)CN1 CHEMBL210995 IC50 1.7 nM
NC1CN(c2cc(-c3cccc(S(=O)(=O)N4CCOCC4)c3)ncn2)CC1c1cc(F)c(F)cc1F CHEMBL246322 Ki 1.7 nM
COc1cc2c(cc1OC)[C@@H]1CC(N)[C@@H](c3cc(C)ccc3C)CN1CC2 CHEMBL601937 IC50 1.7 nM
N[C@@H](CC(=O)N1CCNC(=O)[C@H]1COC1CCCC1)Cc1cc(F)c(F)cc1F CHEMBL1779708 IC50 1.7 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(CC(=O)O)C2 CHEMBL2441844 Ki 1.7 nM
CS(=O)(=O)c1n[nH]c2c1CN([C@H]1CO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL3735917 IC50 1.7 nM
CC(C)S(=O)(=O)c1n[nH]c2c1CN([C@H]1CO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL3735694 IC50 1.7 nM
N[C@H]1C[C@@H](N2Cc3cnc4nc(C5CC5)nn4c3C2)CC[C@@H]1c1cc(F)c(F)cc1F CHEMBL3805346 IC50 1.7 nM
CN1C(=O)Cn2c1nc1nc(N3CCC[C@@H](N)C3)n(Cc3cc(F)ccc3C#N)c1c2=O CHEMBL3687984 IC50 1.7 nM
CS(=O)(=O)n1cc2c(n1)CN([C@@H]1C[C@H](N)C(c3cc(F)ccc3F)N(CCO)C1)C2 CHEMBL3697940 IC50 1.7 nM
NC(=O)Cn1cc2c(n1)CN([C@H]1CSC(c3cc(F)cc(F)c3F)[C@@H](N)C1)C2 CHEMBL3644463 IC50 1.7 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2cccc(F)c2C(=O)O)c1=O CHEMBL4446618 IC50 1.7 nM
CC#CCN1C(N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)=NC2N=C3N(C)C(=O)CN3C(=O)C21 CHEMBL5270313 IC50 1.7 nM
Cc1csc2c(=O)n(Cc3ccccc3C#N)c(N3CCC[C@@H](N)C3)nc12 CHEMBL1651767 IC50 1.72 nM
Cc1cccc(-c2nnc3ccc(N4CCN(C(c5ccccc5)c5ccccc5)CC4)nn23)c1 CHEMBL4460852 IC50 1.75 nM
CC(C)[C@H](Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)CC(N)Cc2ccccc2F)cc1)C(=O)O CHEMBL364100 IC50 1.8 nM
N#C[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)[C@@H](N)C12CC3CC(CC(F)(C3)C1)C2 CHEMBL3350937 Ki 1.8 nM
CN(C)C(=O)[C@@H]1CN[C@H](C(=O)N2CCC[C@H]2C#N)C1 CHEMBL232103 IC50 1.8 nM
N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1B(O)O CHEMBL494497 Ki 1.8 nM
Cc1nc2nc(C(=O)Nc3ccn(C)n3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215165 Ki 1.8 nM
Cn1c(=O)[nH]c2cc(N3CCC[C@@](C)(N)C3)n(Cc3ccccc3)c2c1=O CHEMBL1288231 IC50 1.8 nM
CC(=O)c1cccc(NC(=O)Cc2c(C)nc(CC(C)C)c(CN)c2-c2ccc(C)cc2)c1 CHEMBL3215827 IC50 1.8 nM
Cc1ccc(-c2c(CN)c(CC(C)C)nc3ccc(/C=C/C(N)=O)cc23)cc1 CHEMBL1808468 IC50 1.8 nM
Cc1cc2ncc(C(=O)NCC(C)(C)NCC(=O)N3CCC[C@H]3C#N)c(O)n2n1 CHEMBL1929390 IC50 1.8 nM
N[C@H]1C[C@@H](N2Cc3[nH]nc(NS(=O)(=O)C4CC4)c3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL3734999 IC50 1.8 nM
N[C@H]1C[C@@H](N2Cc3[nH]nc(NS(=O)(=O)Cc4ccncc4)c3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL3735433 IC50 1.8 nM
CCS(=O)(=O)n1cc2c(n1)CN([C@H]1CO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL3735281 IC50 1.8 nM
N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@H]1B(O)O CHEMBL3686749 IC50 1.8 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](NCCc2ccccc2)CN1 CHEMBL194993 IC50 1.9 nM
COCCOc1ccc2nc(C3(NC(=O)C[C@H](N)Cc4cc(Cl)ccc4F)CCOCC3)sc2c1 CHEMBL469317 IC50 1.9 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccc3cc(OC)ccc3n2)c1=O CHEMBL2425892 IC50 1.9 nM
COc1ccccc1N1Cc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)c2C1=O CHEMBL2441830 Ki 1.9 nM
N[C@H]1C[C@@H](N2Cc3cn(S(=O)(=O)c4cccc(C(F)(F)F)c4)nc3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL3736067 IC50 1.9 nM
Cc1cc(C(F)(F)F)nc2c3c(nn12)CN([C@H]1CC[C@H](c2cc(F)c(F)cc2F)[C@@H](N)C1)C3 CHEMBL3804996 IC50 1.9 nM
COc1cc2c3c(ccc2cc1S(C)(=O)=O)O[C@H](c1cc(F)c(F)cc1F)[C@@H](N)C3 CHEMBL3944427 IC50 1.9 nM
N[C@H]1C[C@@H](N2Cc3cn(S(=O)(=O)C4CC4)nc3C2)COC1c1cc(F)c(F)cc1F CHEMBL3645496 IC50 1.9 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1ccccc1C(=O)O)c(=O)n2C CHEMBL4452518 IC50 1.98 nM
CC(C)[C@H](N)C(=O)N1CCC[C@H]1C#N CHEMBL96666 IC50 2.0 nM
CC(C)c1cc(C(=O)O)ccc1OC[C@H]1CC[C@@H](C(=O)N2CCC[C@H]2C#N)N1 CHEMBL436744 Ki 2.0 nM
Cn1c(=O)c2c(nc(N3CCCC(N)C3)n2Cc2ccccc2C#N)n(C)c1=O CHEMBL1161916 Ki 2.0 nM
CN1C(=O)c2nc(N3CCCC(N)C3)n(Cc3ccccc3C#N)c2C1=O CHEMBL1161919 Ki 2.0 nM
CC(C)[C@H](Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)C[C@H](N)Cc2cc(F)c(F)cc2F)cc1)C(=O)O CHEMBL395762 IC50 2.0 nM
Cn1c(C2CC2)nc2ccc(N3CC[C@H](c4cc(F)c(F)cc4F)[C@@H](N)C3)nc21 CHEMBL389804 IC50 2.0 nM
CC(C)=CCn1c(N2CCC[C@H](N)C2)nc2c1c(=O)n(Cc1nccc3ccccc13)c(=O)n2C CHEMBL391089 IC50 2.0 nM
N[C@@H](CC(=O)N1CCn2nc(C(F)(F)F)nc2[C@H]1Cn1cncn1)Cc1cc(F)c(F)cc1F CHEMBL400068 IC50 2.0 nM
N[C@@H](CC(=O)N1CCn2nc(C(F)(F)F)nc2C1Cn1ccnc1)Cc1cc(F)c(F)cc1F CHEMBL250147 IC50 2.0 nM
CC#CCn1c(NC[C@H](C)N)nc2cnn(Cc3nc(C)c4ccccc4n3)c(=O)c21 CHEMBL403408 IC50 2.0 nM
CC#CCn1c(N2CCCC(N)C2)nc2c1c(=O)n(Cc1nc(C)cc3ccccc13)c(=O)n2C CHEMBL402819 IC50 2.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)CCC(=O)N1Cc2ccccc2C1 CHEMBL493543 IC50 2.0 nM
N#C[C@H]1CCCN1C(=O)[C@@H](N)CCC(=O)N1Cc2ccccc2C1 CHEMBL2364733 IC50 2.0 nM
N#Cc1ccc(OC[C@@H]2CCCN2C(=O)C[C@H](N)Cc2cc(F)c(F)cc2F)nc1 CHEMBL563849 IC50 2.0 nM
COc1ccc(N2CCN(CCNCC(=O)N3CCC[C@@H]3C#N)C2=O)cc1OC CHEMBL1202080 IC50 2.0 nM
CC(C)(C)c1noc([C@@H]2CCCN2C(=O)C[C@H](N)Cc2cc(F)c(F)cc2F)n1 CHEMBL565633 IC50 2.0 nM
N[C@@H](CC(=O)N1CCC[C@H]1c1nc(C2(C(F)(F)F)CC2)no1)Cc1cc(F)c(F)cc1F CHEMBL565813 IC50 2.0 nM
N[C@@H](CC(=O)N1CCC[C@H]1c1nc(-c2cnccn2)no1)Cc1cc(F)c(F)cc1F CHEMBL566628 IC50 2.0 nM
CC1(c2nc([C@@H]3CCCN3C(=O)C[C@H](N)Cc3cc(F)c(F)cc3F)no2)COC1 CHEMBL565600 IC50 2.0 nM
Cc1nc2nc(C(=O)NCc3ncco3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215163 Ki 2.0 nM
Cc1nc2nc(C(=O)Nc3ccnn3C)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215234 Ki 2.0 nM
CC(C)=CCn1c(N2CCC[C@H](N)C2)c(C#N)c2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C CHEMBL1951600 IC50 2.0 nM
CC#CCn1c(N2CCC[C@H](N)C2)c(C#N)c2c1c(=O)n(CC(=O)c1cccc(OC)c1)c(=O)n2C CHEMBL1951603 IC50 2.0 nM
COc1cccc(C(=O)Cn2c(=O)c3c(c(C#N)c(N4CCCNCC4)n3CC=C(C)C)n(C)c2=O)c1 CHEMBL1951607 IC50 2.0 nM
CC(C)=CCn1c(N2CCCNCC2)c(C#N)c2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C CHEMBL1951609 IC50 2.0 nM
CC#CCn1c(N2CCCNCC2)c(C#N)c2c1c(=O)n(Cc1c(C#N)cnc3ccccc13)c(=O)n2C CHEMBL1951614 IC50 2.0 nM
N#C[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)[C@@H](N)C1CCN(C(=O)c2ccc3cnccc3n2)CC1 CHEMBL2334700 Ki 2.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccc3cc(F)ccc3n2)c1=O CHEMBL2425890 IC50 2.0 nM
NC[C@]1(c2cccc(Cl)c2)CC[C@H](N2CCc3c(nc(C(F)(F)F)nc3C3CC3)C2=O)CC1 CHEMBL3112968 IC50 2.0 nM
CC#CCn1c(N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)nc2c1c(=O)n(Cc1cc(C#N)c3ccccc3n1)c(=O)n2C CHEMBL3680631 IC50 2.0 nM
CC#CCn1c(N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)nc2c1c(=O)n(Cc1ccc3nc(C)c(C)nc3c1)c(=O)n2C CHEMBL3680633 IC50 2.0 nM
CC#CCn1c(N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)nc2c1c(=O)n(CC(=O)c1ccccc1Br)c(=O)n2C CHEMBL3680634 IC50 2.0 nM
CC#CCn1c(N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)nc2c1c(=O)n(Cc1nc3ccccc3c(C)c1C#N)c(=O)n2C CHEMBL3680635 IC50 2.0 nM
CC#CCn1c(N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)nc2c1c(=O)n(Cc1nccc(-c3ccccc3)n1)c(=O)n2C CHEMBL3680636 IC50 2.0 nM
N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1B(O)O CHEMBL3686747 IC50 2.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1OCC(=O)NCC)c(=O)n2C CHEMBL3955534 IC50 2.0 nM
C/C=C/Cn1c(N2CCCC(N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1NC(C)=O)c(=O)n2C CHEMBL3889902 IC50 2.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1cc(C)c3nccnc3c1)c(=O)n2C CHEMBL3938646 IC50 2.0 nM
Cc1cccc(-c2nnc3ccc(N4CCN(Cc5ccc(F)cc5)CC4)nn23)c1 CHEMBL4547171 IC50 2.0 nM
Fc1ccc(CNc2cc(N3CCNCC3)nc3ccnn23)c(F)c1 CHEMBL4784434 IC50 2.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(CC1=NC3C=CC=CC3C(C)=N1)c(=O)n2C CHEMBL4747683 IC50 2.0 nM
COc1cc2ccc3c(c2cc1OC)C[C@H](N)[C@@H](c1cc(F)c(F)cc1F)O3 CHEMBL3941804 IC50 2.06 nM
CC#CCN1C(N2CCC[C@H](N)C2)=NC2C1C(=O)N(C(C)c1nc(C)c3ccccc3n1)C(=O)N2C CHEMBL4649180 IC50 2.07 nM
N#C[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)[C@@H](N)C12CC3CC(O)(CC(O)(C3)C1)C2 CHEMBL3350936 Ki 2.1 nM
C[C@H](N)C(=O)N1C[C@H](F)C[C@H]1B(O)O CHEMBL2063026 IC50 2.1 nM
CNC(=O)CN1Cc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)c2C1=O CHEMBL2441951 Ki 2.1 nM
Cc1ccc(-c2c(-c3nc(C(N)=O)cs3)cnc(CC(C)C)c2CN)cc1 CHEMBL4068477 IC50 2.1 nM
CCC(C)[C@H](N)C(=O)N1CCC[C@H]1C#N CHEMBL329641 Ki 2.2 nM
CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C#N CHEMBL3350819 Ki 2.2 nM
CN(C)C(=O)[C@@H](c1ccc(-c2cccc(-n3cnnn3)c2)cc1)[C@H](N)C(=O)N1CC[C@H](F)C1 CHEMBL191473 IC50 2.2 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2ccc(F)cc2F)cc1 CHEMBL199905 Ki 2.2 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNC(=O)C1CCC1)Cc1cc(F)c(F)cc1F CHEMBL563901 IC50 2.2 nM
Cc1nc2nc(C(=O)N3CCOCC3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1214943 Ki 2.2 nM
CC(C)OC[C@@H]1C(=O)NCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL1779709 IC50 2.2 nM
Cc1ccc(-c2c(CN)c(CC(C)C)nc3ccc(N4CCNC(=O)C4)cc23)cc1 CHEMBL1808473 IC50 2.2 nM
O=C([C@@H]1C[C@H](N2CCN(c3ccc4ccccc4n3)CC2)CN1)N1CCSC1 CHEMBL2058968 IC50 2.2 nM
CS(=O)(=O)n1cc2c(n1)CN([C@H]1COC(c3cc(F)c(F)cc3F)[C@@H](N)C1)C2 CHEMBL3645491 IC50 2.2 nM
N[C@H]1C[C@@H](N2Cc3cnn(-c4ncccn4)c3C2)CCO[C@@H]1c1cc(F)ccc1F CHEMBL3654419 IC50 2.2 nM
Cc1nnc(N2CCC[C@@H](N)C2)n(Cc2cc(F)ccc2C#N)c1=O CHEMBL5408495 IC50 2.2 nM
Cc1cccc(-c2nnc3ccc(N4CCN(C(=O)c5ccccc5)CC4)nn23)c1 CHEMBL4529301 IC50 2.25 nM
COc1ccccc1N1CCc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)c2C1=O CHEMBL459807 IC50 2.28 nM
N[C@H]1CN(c2cc(N3CC[C@@H](O)C3)ncn2)C(=O)C[C@@H]1c1cc(F)c(F)cc1F CHEMBL222908 Ki 2.3 nM
N[C@H]1CN(c2cc(N3CCCC3)ncn2)C(=O)C[C@@H]1c1cc(F)c(F)cc1F CHEMBL224882 Ki 2.3 nM
C[C@@H](B(O)O)N1CC[C@@H](N)C1=O CHEMBL2068511 Ki 2.3 nM
CN(C)C(=O)[C@@H]([C@H]1CC[C@H](c2cccc3ncnn32)CC1)[C@H](N)C(=O)N1CC[C@H](F)C1 CHEMBL400841 IC50 2.3 nM
O=C([C@@H]1C[C@H](N2CCC(c3ccc([N+](=O)[O-])cc3)CC2)CN1)N1CCSC1 CHEMBL238516 IC50 2.3 nM
N#Cc1ccnc(OC[C@@H]2CCCN2C(=O)C[C@H](N)Cc2cc(F)c(F)cc2F)c1 CHEMBL565101 IC50 2.3 nM
C[C@H](N)C(=O)N1C[C@@H](O)C[C@H]1B(O)O CHEMBL2063024 IC50 2.3 nM
N#Cc1ccc(C(=O)NCCCC(=O)N2CCC[C@H]2C#N)cc1 CHEMBL2086613 IC50 2.3 nM
Cc1cc(CN2Cc3nc(C)c(CN)c(-c4ccc(Cl)cc4Cl)c3C2=O)no1 CHEMBL2441835 Ki 2.3 nM
N[C@H]1C[C@@H](N2Cc3cn(S(=O)(=O)C(F)(F)F)nc3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL3736188 IC50 2.3 nM
N[C@H]1C[C@@H](N2Cc3cn(S(=O)(=O)c4ccccc4)nc3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL3736511 IC50 2.3 nM
N[C@H]1C[C@@H](N2Cc3c[nH]nc3C2)CSC1c1cc(F)ccc1F CHEMBL3644451 IC50 2.3 nM
CS(=O)(=O)n1cc2c(n1)CN([C@H]1CCO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL3654418 IC50 2.3 nM
N#Cc1ccc(F)cc1Cn1c(N2CCC[C@@H](N)C2)nc2cc[nH]c2c1=O CHEMBL4162340 IC50 2.3 nM
O=C(CNc1nc(Nc2ccc(S(=O)(=O)Nc3nccs3)cc2)nc(N2CCOCC2)n1)Nc1ccc(F)cc1 CHEMBL5275453 IC50 2.32 nM
O=C(CNc1nc(Nc2ccc(S(=O)(=O)Nc3cncs3)cc2)nc(N2CCOCC2)n1)Nc1ccc(F)cc1 CHEMBL5271401 IC50 2.32 nM
N#Cc1ccccc1Cn1c(N2CCC[C@@H](N)C2)nc2[nH]c(-c3cccnc3)cc2c1=O CHEMBL2023066 IC50 2.34 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1ccc(F)cc1C(=O)O)c(=O)n2C CHEMBL4528994 IC50 2.35 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](C2CCCCC2)CN1 CHEMBL242492 IC50 2.4 nM
CN(C)C(=O)CC[C@@H]1CN[C@H](C(=O)N2CCC[C@H]2C#N)C1 CHEMBL232311 IC50 2.4 nM
O=C([C@@H]1C[C@H](N2CCCN(c3ccc([N+](=O)[O-])cc3)CC2)CN1)N1CCSC1 CHEMBL239356 IC50 2.4 nM
N#Cc1ccc(CN2C[C@H](N)[C@H](C(=O)N3CCC[C@H]3C#N)C2)cc1 CHEMBL248599 IC50 2.4 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)CNCCNc1ccc(C(N)=O)cn1 CHEMBL521224 IC50 2.4 nM
CCN(CC)C(=O)c1cn2c(-c3ccc(Cl)cc3Cl)c(CN)c(C)nc2n1 CHEMBL1214877 Ki 2.4 nM
N#Cc1ccc(F)cc1Cn1c(N2CCC[C@@H](N)C2)nc2[nH]ccc2c1=O CHEMBL4169618 IC50 2.4 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1cc(C#N)ccc1C(=O)O)c(=O)n2C CHEMBL4464069 IC50 2.43 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2ccc3ccccc3c2)N1 CHEMBL379812 Ki 2.5 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](c2ccc(O)cc2)CN1 CHEMBL390221 IC50 2.5 nM
CN(C)C(=O)[C@@H]([C@H]1CC[C@H](c2cccc3ncnn32)CC1)[C@H](N)C(=O)N1CCC(F)(F)C1 CHEMBL237997 IC50 2.5 nM
O=C([C@@H]1C[C@H](N2CCN(c3ccc(Cl)cn3)CC2)CN1)N1CCSC1 CHEMBL239565 IC50 2.5 nM
Cc1ccc(-c2c(CN)c(CC(C)(C)C)nc(Cc3ccccc3)c2C(=O)O)cc1 CHEMBL3216060 IC50 2.5 nM
CCN(CC)C(=O)[C@@H](C)N1Cc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)c2C1=O CHEMBL2441848 Ki 2.5 nM
CS(=O)(=O)n1cc2c(n1)CN([C@H]1COC(c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL3645490 IC50 2.5 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2cc(Br)ccc2C(=O)O)c1=O CHEMBL4558007 IC50 2.5 nM
N[C@H]1C[C@@H](N2Cc3nn4c(C(F)(F)F)cc(C(F)(F)F)nc4c3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL5418259 IC50 2.5 nM
N[C@H](C(=O)N1CCCC1)[C@H]1CC[C@H](NS(=O)(=O)c2ccc(NS(=O)(=O)CC(F)(F)F)cc2)CC1 CHEMBL497992 IC50 2.6 nM
N[C@@H](CC(=O)N1CCCNC(=O)[C@H]1CC(F)(F)F)Cc1cc(F)c(F)cc1F CHEMBL217271 IC50 2.6 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)CNC1CCCC1 CHEMBL470477 IC50 2.6 nM
COc1cc2c(cc1OC)[C@@H]1C[C@H](N)[C@@H](N3C[C@H](C)CC3=O)CN1CC2 CHEMBL591291 IC50 2.6 nM
Cc1nc2nc(C(=O)N(C)Cc3cccnc3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215167 Ki 2.6 nM
Cc1nc2nc(C(=O)N(C)Cc3ccncc3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215299 Ki 2.6 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(Cc1ncco1)C2 CHEMBL2441834 Ki 2.6 nM
CC(C)(O)Cn1cc2c(n1)CN([C@H]1CSC(c3cc(F)cc(F)c3F)[C@@H](N)C1)C2 CHEMBL3644455 IC50 2.6 nM
NC(=O)c1n[nH]c2c1CN([C@H]1CCO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL3654422 IC50 2.6 nM
N[C@H]1C[C@@H](N2Cc3cnn(S(=O)(=O)C4CCCC4)c3C2)COC1c1cc(F)c(F)cc1F CHEMBL3935335 IC50 2.6 nM
Cc1ccc(-c2c(CCc3nc(C(=O)O)cs3)c(C)nc(CC(C)C)c2CN)cc1 CHEMBL4098218 IC50 2.6 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2cc(C(=O)OC)ccc2Br)c1=O CHEMBL4856255 IC50 2.6 nM
N#Cc1ccccc1Cn1c(N2CCC[C@@H](N)C2)nc2[nH]c(Br)cc2c1=O CHEMBL2022467 IC50 2.64 nM
N#C[C@@H]1CCCN1C(=O)CN[C@]12C[C@@H]3C[C@@H](C[C@@](O)(C3)C1)C2 CHEMBL3084811 IC50 2.7 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2ccc3c(c2)OCO3)N1 CHEMBL379368 Ki 2.7 nM
CN(C)C(=O)[C@@H](c1ccc(-c2ccc3ncnn3c2)cc1)[C@H](N)C(=O)N1CC(F)C1 CHEMBL210974 IC50 2.7 nM
O=C([C@@H]1C[C@H](N2CCN(c3ccccn3)CC2)CN1)N1CCSC1 CHEMBL395854 IC50 2.7 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)CNCCNc1ccc(Cl)cn1 CHEMBL500008 IC50 2.7 nM
COc1ccc2nc(C3(NC(=O)C[C@H](N)Cc4cc(F)c(F)cc4F)CCS(=O)(=O)CC3)sc2c1 CHEMBL470356 IC50 2.7 nM
N[C@@H](CC(=O)N1CCC[C@H]1CN(C1CC1)S(=O)(=O)C(F)(F)F)Cc1cc(F)c(F)cc1F CHEMBL558647 IC50 2.7 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNC(=O)C1(C(F)(F)F)CC1)Cc1cc(F)c(F)cc1F CHEMBL552069 IC50 2.7 nM
Cc1ccc(-c2c(CN)c(CC(C)C)nc3ccc(N4CCNC(=O)C4=O)cc23)cc1 CHEMBL1808474 IC50 2.7 nM
COC(=O)CN1Cc2c(nc(C)c(CN)c2-c2ccc(Cl)cc2Cl)C1=O CHEMBL1910111 Ki 2.7 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(C[C@H]1CCCO1)C2 CHEMBL2441838 Ki 2.7 nM
CCOC(=O)c1c(C(C)C)cc(C(C)C)c(C(=O)OCC)c1-c1cc2ccc(-c3ccc4c(C)cccc4c3)cc2[nH]1 CHEMBL4632896 IC50 2.72 nM
C[C@@H]1CCN(C(=O)C[C@H](N)Cc2cc(F)c(F)cc2F)[C@H](Cc2ccccc2F)C(=O)N1 CHEMBL395798 IC50 2.77 nM
CN(C)C(=O)CC1c2nnc(C(F)(F)F)n2CCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL556979 IC50 2.8 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)CNCCNc1ccccn1 CHEMBL487680 IC50 2.8 nM
Cc1ccc(-c2c(CC(=O)Nc3cccc([S+](C)[O-])c3)c(C)nc(CC(C)C)c2CN)cc1 CHEMBL1644844 IC50 2.8 nM
CNc1nc2c(c(-c3cc(F)ccc3Br)c1CN)c(=O)n(C)c(=O)n2C CHEMBL2159190 IC50 2.8 nM
CCN(CC)c1nc2c(c(-c3cc(F)ccc3Br)c1CN)c(=O)n(C)c(=O)n2C CHEMBL2159192 IC50 2.8 nM
Cc1ccc(NS(=O)(=O)c2ccc3c(c2)CCCC3)cc1 CHEMBL4641140 IC50 2.8 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2cc(C(=O)O)ccc2F)c1=O CHEMBL4857729 IC50 2.8 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1 CHEMBL381626 IC50 2.9 nM
CC(C)C[C@@H]1CN[C@H](C(=O)N2CCC[C@H]2C#N)C1 CHEMBL242987 IC50 2.9 nM
CC12CC3(C)CC(O)(C1)CC([C@H](N)C(=O)N1CC[C@@H]4C[C@@H]41)(C2)C3 CHEMBL391211 Ki 2.9 nM
CC(C)(C)NCC(=O)N1C[C@@H](F)C[C@H]1C#N CHEMBL512726 IC50 2.9 nM
CC(C)(CNC(=O)c1ccc2c(c1)CCO2)NCC(=O)N1C[C@@H](F)C[C@H]1C#N CHEMBL488036 IC50 2.9 nM
Cc1nc2nc(C(=O)N3CCCC3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1214942 Ki 2.9 nM
Cc1ccc(-c2c(CC(=O)N3CCC[C@H]3C(=O)O)c(C)nc(CC(C)C)c2CN)cc1 CHEMBL3216485 IC50 2.9 nM
Cc1cc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)n(-c2ccc(F)cc2)n1 CHEMBL2147711 IC50 2.9 nM
CCN1C(=O)CN(C(=O)C[C@H](N)[C@H]2CCc3cc(F)c(F)cc32)Cc2ccccc21 CHEMBL3580790 IC50 2.9 nM
Cc1ccnc2c3c(nn12)CN([C@H]1CO[C@H](c2cc(F)ccc2F)[C@@H](N)C1)C3 CHEMBL3804950 IC50 2.9 nM
N[C@H]1C[C@@H](N2Cc3cn[nH]c3C2)CN(Cc2cn[nH]c2)C1c1cc(F)ccc1F CHEMBL3697947 IC50 2.9 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1ccccc1C(=O)OC)c(=O)n2C CHEMBL4435383 IC50 2.91 nM
NCc1c(N)nc(-c2ccc(F)c(F)c2)nc1-c1ccc(Cl)cc1Cl CHEMBL37960 IC50 3.0 nM
C[S+](C)Cc1ccc2cc1C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N2 CHEMBL302602 IC50 3.0 nM
N#C[C@@H]1CCCN1C(=O)CNC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3 CHEMBL319080 IC50 3.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](NC2CCCCC2)CN1 CHEMBL192882 IC50 3.0 nM
C[C@@H](c1ccc(-c2cccc(-c3noc(O)n3)c2)cc1)[C@H](N)C(=O)N1CC[C@H](F)C1 CHEMBL370072 IC50 3.0 nM
CCN(CC#N)C(=O)[C@@H](N)C12CC3CC(CC(O)(C3)C1)C2 CHEMBL203618 Ki 3.0 nM
C#C[C@H]1CC[C@@H](C#N)N1C(=O)CNC1(C)CCN(c2ccc(C#N)cn2)CC1 CHEMBL387297 Ki 3.0 nM
N[C@H]1CN(c2cc(N3CCn4cc(C(F)(F)F)nc4C3)ncn2)C(=O)C[C@@H]1c1cc(F)c(F)cc1F CHEMBL222144 Ki 3.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nc(C)cc3ccccc13)c(=O)n2C CHEMBL237499 IC50 3.0 nM
O=C([C@@H]1C[C@H](N2CCN(c3ccc(Cl)c(Cl)c3)CC2)CN1)N1CCSC1 CHEMBL241246 IC50 3.0 nM
CC(c1ccc(-n2cncn2)cc1)N1C[C@H](N)[C@H](C(=O)C2CCC[C@H]2C#N)C1 CHEMBL400532 IC50 3.0 nM
CC#CCn1c(N2CCCNCC2)nc2cnn(Cc3nc(C)c4ccccc4n3)c(=O)c21 CHEMBL257999 IC50 3.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2cnn(CC3=Nc4ccccc4Oc4ccccc43)c(=O)c21 CHEMBL401502 IC50 3.0 nM
N[C@@H](CC(=O)N1CCC[C@H]1c1nc(CC2CC2)no1)Cc1cc(F)c(F)cc1F CHEMBL566672 IC50 3.0 nM
N[C@@H](CC(=O)N1CCC[C@H]1c1nc(-c2ncc(F)cc2F)no1)Cc1cc(F)c(F)cc1F CHEMBL566829 IC50 3.0 nM
N#Cc1ccsc1Cn1c(N2CCC[C@@H](N)C2)ncc(Br)c1=O CHEMBL1650430 IC50 3.0 nM
CC(C)C(Nc1ccc(CNC(=O)C2SCCN2C(=O)C[C@H](N)Cc2cc(F)c(F)cc2F)cc1)C(=O)O CHEMBL1683504 IC50 3.0 nM
NCc1c(N)nc(-c2cc(F)cc(F)c2)nc1-c1ccc(Cl)cc1Cl CHEMBL1909975 IC50 3.0 nM
COc1ccccc1N1Cc2c(nc(C)c(CN)c2-c2ccc(Cl)cc2Cl)C1=O CHEMBL1909991 Ki 3.0 nM
CC(C)=CCn1c(N2CCC[C@H](N)C2)c(C#N)c2ncn(Cc3nc(C)c4ccccc4n3)c(=O)c21 CHEMBL1951433 IC50 3.0 nM
CC(C)=CCn1c(N2CCCNCC2)c(C#N)c2c1c(=O)n(Cc1nccc3ccccc13)c(=O)n2C CHEMBL1951608 IC50 3.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1ccc(F)cc1 CHEMBL3093903 IC50 3.0 nM
NC[C@]1(c2cccc(Cl)c2)CC[C@H](n2nc(-c3ccccc3)ccc2=O)CC1 CHEMBL3112959 IC50 3.0 nM
CN1C(=O)CN(C(=O)C[C@H](N)[C@H]2CCc3cc(F)c(F)cc32)Cc2ccccc21 CHEMBL3580788 IC50 3.0 nM
CC#CCn1c(N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)nc2c1c(=O)n(CC(=O)c1ccccc1[N+](=O)[O-])c(=O)n2C CHEMBL3680637 IC50 3.0 nM
CS(=O)(=O)n1cc2c(n1)CN([C@@H]1C[C@H](N)C(c3cc(F)ccc3F)N(Cc3cncnc3)C1)C2 CHEMBL3697946 IC50 3.0 nM
NCC(=S)N1CCC[C@H]1B(O)O CHEMBL3686738 IC50 3.0 nM
N[C@H]1C[C@@H](N2Cc3cnn(-c4ccccc4)c3C2)CCO[C@@H]1c1cc(F)ccc1F CHEMBL3654420 IC50 3.0 nM
C/C=C/Cn1c(N2CCCC(N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1NC(=O)C(C)C)c(=O)n2C CHEMBL3987141 IC50 3.0 nM
C/C=C/Cn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C CHEMBL3958450 IC50 3.0 nM
CC#CCn1c(N2CCC[C@H](N)C2)nc2c1c(=O)n(Cc1nc(C)cc3ccccc13)c(=O)n2C CHEMBL3898310 IC50 3.0 nM
CC#CCn1c(N2CCC[C@H](N)C2)nc2c1c(=O)n(Cc1ncc(C)c3ccccc13)c(=O)n2C CHEMBL3966199 IC50 3.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(CC(=O)c1cccc3c1OCCO3)c(=O)n2C CHEMBL3974699 IC50 3.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1NC(=O)C(C)C)c(=O)n2C CHEMBL3903674 IC50 3.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1ccc(C#N)c3ccccc13)c(=O)n2C CHEMBL3981831 IC50 3.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(CC(=O)c1cccc(OC)c1)c(=O)n2C CHEMBL3939916 IC50 3.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1ccccc1F CHEMBL5267474 IC50 3.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2ccc(F)cc2)cc1 CHEMBL199614 Ki 3.1 nM
O=C([C@@H]1C[C@H](N2CCN(c3ccncc3)CC2)CN1)N1CCSC1 CHEMBL239564 IC50 3.1 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CC3CC(CC(O)(C3)C1)C2 CHEMBL469659 IC50 3.1 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)CNC1C2CC3CC(C2)CC1C3 CHEMBL451937 IC50 3.1 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)CNC1CCC1 CHEMBL470476 IC50 3.1 nM
Cc1nc2nc(C(=O)NC3CCOCC3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1214944 Ki 3.1 nM
COC[C@H]1CCCN1C(=O)c1cn2c(-c3ccc(Cl)cc3Cl)c(CN)c(C)nc2n1 CHEMBL1215017 Ki 3.1 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccc3ccccc3n2)c1=O CHEMBL2425886 IC50 3.1 nM
N[C@H]1CN(CCc2ccc3c(c2)OCO3)C(=O)C[C@@H]1c1cc(F)c(F)cc1F CHEMBL538090 Ki 3.2 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CN(Cc2ccc(-n3cncn3)cc2)C[C@@H]1N CHEMBL399525 IC50 3.2 nM
CS(=O)(=O)c1ccc(-c2noc([C@@H](CCO)[C@H](N)C(F)=C3CCCC3)n2)c(Cl)c1 CHEMBL445674 IC50 3.2 nM
N#Cc1cccnc1NC[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL562072 IC50 3.2 nM
Cc1nc2nc(C(=O)NCc3cccs3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215235 Ki 3.2 nM
N[C@H]1CN(CCc2ccc3c(c2)OCO3)C(=O)C[C@@H]1c1cc(F)c(F)cc1F CHEMBL225210 Ki 3.2 nM
CS(=O)(=O)Nc1n[nH]c2c1CN([C@H]1CO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL3734769 IC50 3.2 nM
CN(C)C(=O)[C@@H](c1ccc(-c2ccc(F)cc2)cc1)[C@H](N)C(=O)N1CCC[C@H]1C#N CHEMBL189055 IC50 3.3 nM
Cc1cc(O)cc(C)c1[C@@H]1CN[C@H](C(=O)N2CCC[C@H]2C#N)C1 CHEMBL243799 IC50 3.3 nM
Cn1nccc1-c1ccc(CN2C[C@H](N)[C@H](C(=O)N3CCC[C@H]3C#N)C2)cc1 CHEMBL248793 IC50 3.3 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)CNC1CCCCCCC1 CHEMBL470681 IC50 3.3 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)CNC1(CO)CCCC1 CHEMBL513725 IC50 3.3 nM
COc1ccc2sc(C3(NC(=O)C[C@H](N)Cc4cc(F)c(F)cc4F)CCS(=O)(=O)CC3)nc2c1 CHEMBL470357 IC50 3.3 nM
Cc1cc2ncc(C(=O)NCC(C)(C)NCC(=O)N3CCC[C@H]3C#N)cn2n1 CHEMBL1929396 IC50 3.3 nM
CCC[C@@H]1CN[C@H](C(=O)N2CCC[C@H]2C#N)C1 CHEMBL242985 IC50 3.4 nM
CS(=O)(=O)c1cccc(-c2cc(N3CC(N)C(c4cc(F)c(F)cc4F)C3)ncn2)c1 CHEMBL428223 Ki 3.4 nM
N#Cc1ccc2c(c1)CCC2N1C[C@H](N)[C@H](C(=O)C2CCC[C@H]2C#N)C1 CHEMBL249408 IC50 3.4 nM
Cc1cc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)n(-c2ccc(Cl)cc2)n1 CHEMBL2147714 IC50 3.4 nM
O=C(NC[C@@H]1CN[C@H](C(=O)N2CCSC2)C1)c1cscn1 CHEMBL1230909 Ki 3.4 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ncccn2)c1=O CHEMBL2425884 IC50 3.4 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(Cc1ccn(C)n1)C2 CHEMBL2441833 Ki 3.4 nM
Cc1oc(=O)oc1COC(=O)c1ccc2c3nc(N4CCC[C@@H](N)C4)n(Cc4cc(F)ccc4Cl)c3c(=O)n(C)c2c1 CHEMBL3400966 IC50 3.4 nM
CN1C(=O)CN(C(=O)C[C@H](N)[C@H]2CCc3cc(F)c(F)cc32)Cc2ccc(F)cc21 CHEMBL3580789 IC50 3.4 nM
CCOC(=O)CN1C(=O)CN(C(=O)C[C@H](N)[C@H]2CCc3cc(F)c(F)cc32)Cc2ccccc21 CHEMBL3580792 IC50 3.4 nM
N[C@H]1C[C@@H](N2Cc3c[nH]nc3C2)CSC1c1cc(F)cc(F)c1F CHEMBL3644452 IC50 3.4 nM
CC(C)(C)[C@H](N)C(=O)N1CCSCC1 CHEMBL4241283 IC50 3.4 nM
Cc1ccc2c(c1)CN(C(=O)CC(C)(C)NCC(=O)N1CCC[C@H]1C#N)C2 CHEMBL5430453 IC50 3.4 nM
Cc1ccccc1OC[C@H]1CC[C@@H](C(=O)N2CCC[C@H]2C#N)N1 CHEMBL382167 Ki 3.5 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](c2ccccc2)CN1 CHEMBL396512 IC50 3.5 nM
C=CC[C@@H]1CN[C@H](C(=O)N2CCC[C@H]2C#N)C1 CHEMBL245069 IC50 3.5 nM
CNC(=O)[C@@H]1CN[C@H](C(=O)N2CCC[C@H]2C#N)C1 CHEMBL391559 IC50 3.5 nM
N#C[C@@H]1CCCC1C(=O)[C@@H]1CN(C2CCOc3ccccc32)C[C@@H]1N CHEMBL400533 IC50 3.5 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNC(=O)CC(F)(F)F)Cc1cc(F)c(F)cc1F CHEMBL550114 IC50 3.5 nM
N#Cc1ccc(NC[C@@H]2CCCN2C(=O)C[C@H](N)Cc2cc(F)c(F)cc2F)nc1 CHEMBL563244 IC50 3.5 nM
Cn1c(=O)c2c(nc(N3CCC[C@@H](N)C3)n2Cc2ccccc2Cl)c2cc(CC(=O)O)ccc21 CHEMBL2147083 IC50 3.5 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1cscn1 CHEMBL3127986 Ki 3.5 nM
N[C@H]1C[C@@H](N2Cc3nn4cncnc4c3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL3805353 IC50 3.5 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2cc(C#N)ccc2C(=O)O)c1=O CHEMBL4516959 IC50 3.5 nM
NC(=O)c1cccc(OCC2=CC[C@H](c3cc(F)c(F)c(F)c3)[C@@H](N)C2)c1 CHEMBL410514 Ki 3.6 nM
N#Cc1cc(CN2C[C@H](N)[C@H](C(=O)N3CCC[C@H]3C#N)C2)ccc1F CHEMBL438520 IC50 3.6 nM
COCCOc1ccc2nc(C3(NC(=O)C[C@H](N)Cc4cc(F)c(F)cc4F)CCOCC3)sc2c1 CHEMBL470164 IC50 3.6 nM
N#Cc1ccc(N[C@@H]2CN[C@H](C(=O)N3[C@@H]4C[C@@H]4C[C@@H]3C#N)C2)cc1Cl CHEMBL458744 Ki 3.6 nM
COc1cc2c(cc1OC)[C@@H]1C[C@H](N)[C@@H](N3C[C@H](CF)CC3=O)CN1CC2 CHEMBL591117 IC50 3.6 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2cccc(C(=O)NC)c2)c1=O CHEMBL5286666 IC50 3.6 nM
CC(C)C(Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)CC(N)Cc2ccccc2F)cc1)C(=O)O CHEMBL365837 IC50 3.7 nM
CC(C)(C)C(=O)NC[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL558322 IC50 3.7 nM
COc1cc2c(cc1OC)C1CC(N)C(N3CC(C)CCC3=O)CN1CC2 CHEMBL590329 IC50 3.7 nM
COC(=O)c1cccc(NC(=O)Cc2c(C)nc(CC(C)C)c(CN)c2-c2ccc(C)cc2)c1 CHEMBL3216724 IC50 3.7 nM
N[C@H]1C[C@@H](N2Cc3[nH]nc(NC(=O)c4ccncc4)c3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL3735925 IC50 3.7 nM
N[C@H]1C[C@@H](N2Cc3nn4cccnc4c3C2)CC[C@@H]1c1cc(F)c(F)cc1F CHEMBL3806003 IC50 3.7 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2cn(Cc3ccc(F)cc3)nn2)cc1 CHEMBL2418626 IC50 3.79 nM
N#CC1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2cn(Cc3ccc(F)cc3)nn2)cc1 CHEMBL5276287 IC50 3.79 nM
CC(C)(C)[C@H](N)C(=O)N1CCC[C@H]1C#N CHEMBL363250 Ki 3.8 nM
CC(C)(C)c1cc(C(=O)O)ccc1OC[C@H]1CC[C@@H](C(=O)N2CCC[C@H]2C#N)N1 CHEMBL382003 Ki 3.8 nM
N[C@H]1CN(CCc2cccc(C(=O)O)c2)C(=O)C[C@@H]1c1cc(F)c(F)cc1F CHEMBL221402 Ki 3.8 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](CCO)CN1 CHEMBL395919 IC50 3.8 nM
Cc1cc(-n2cncn2)ccc1CN1C[C@H](N)[C@H](C(=O)C2CCC[C@H]2C#N)C1 CHEMBL250620 IC50 3.8 nM
Cc1nc2nc(C(=O)Nc3ccon3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215166 Ki 3.8 nM
Cc1cc2ncc(C(=O)NCC(C)(C)NCC(=O)N3CCC[C@H]3C#N)cn2n1 CHEMBL1929387 IC50 3.8 nM
N#C[C@@H]1CCCN1C(=O)CCCNC(=O)c1ccc(C(F)(F)F)cc1 CHEMBL2086614 IC50 3.8 nM
Cn1c(=O)c2c(nc(N3CCC[C@@H](N)C3)n2Cc2ccccc2Cl)c2ccc(CC(=O)O)cc21 CHEMBL2147074 IC50 3.8 nM
CC(C)(C)c1cc(C(=O)O)ccc1OC[C@H]1CC[C@@H](C(=O)N2CCC[C@H]2CN)N1 CHEMBL1230826 Ki 3.8 nM
N[C@@H](CC(=O)N1CC(=O)Nc2cc(F)ccc2C1)[C@H]1CCc2cc(F)c(F)cc21 CHEMBL3580779 IC50 3.8 nM
C=CC1([C@H](N)C(=O)N2[C@H](C#N)C[C@@H]3C[C@@H]32)CCCC1 CHEMBL3350932 Ki 3.9 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](c2cccc(O)c2)CN1 CHEMBL243798 IC50 3.9 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNc1nccc(C(F)(F)F)n1)Cc1cc(F)c(F)cc1F CHEMBL549296 IC50 3.9 nM
CS(=O)(=O)n1cc2c(n1)CN([C@H]1C[C@H](N)C(c3cc(F)ccc3F)N(Cc3cn[nH]c3)C1)C2 CHEMBL3697949 IC50 3.9 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1c(Cl)cccc1C(=O)O)c(=O)n2C CHEMBL4458949 IC50 3.9 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccc(Cl)cc2C(=O)O)c1=O CHEMBL4562685 IC50 3.9 nM
CS(=O)(=O)n1cc2c(n1)CN([C@@H]1C[C@H](N)[C@@H](c3cc(F)c(F)cc3F)O[C@@H]1C(F)(F)F)C2 CHEMBL4641763 IC50 3.9 nM
COc1ccc2c(c1)CN[C@H](C(=O)N1CCC[C@H]1C#N)C2 CHEMBL186566 IC50 4.0 nM
N#Cc1ccc(O[C@H]2CC[C@H](NCC(=O)N3CCC[C@H]3C#N)CC2)nc1 CHEMBL3085037 Ki 4.0 nM
CN1C(=O)C=C(N2CCC[C@@H](N)C2)C(Cc2ccccc2C#N)C1=O CHEMBL216253 IC50 4.0 nM
CS(=O)(=O)c1cccc(-c2cc(N3C[C@H](N)[C@@H](c4cc(F)c(F)cc4F)CC3=O)ncn2)c1 CHEMBL222323 Ki 4.0 nM
CS(=O)(=O)c1cccc(CCN2C[C@H](N)[C@@H](c3cc(F)c(F)cc3F)CC2=O)c1 CHEMBL426896 Ki 4.0 nM
COc1cc2c(=O)n(Cc3ccccc3C#N)c(N3CCC[C@@H](N)C3)nc2cc1F CHEMBL375508 IC50 4.0 nM
N#Cc1ccccc1Cn1c(N2CCC[C@@H](N)C2)nc2ccc(F)cc2c1=O CHEMBL425483 IC50 4.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](C(=O)N2CCC2)CN1 CHEMBL234373 IC50 4.0 nM
COc1cc2c(cc1OC)[C@@H]1C[C@H](N)[C@@H](c3cccc(Cl)c3)CN1CC2 CHEMBL232595 IC50 4.0 nM
COc1cc2c(cc1OC)[C@@H]1C[C@H](N)[C@@H](c3cccc(C)c3)CN1CC2 CHEMBL391070 IC50 4.0 nM
CN(C)C(=O)[C@@H](c1ccc(-c2ccc3ncnn3c2)cc1)[C@H](N)C(=O)N1CC[C@H](F)C1 CHEMBL237337 IC50 4.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C CHEMBL237287 IC50 4.0 nM
CC(C)=CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nccc3ccccc13)c(=O)n2C CHEMBL429450 IC50 4.0 nM
CN(C)C(=O)[C@@H](c1ccc(-c2ccc3ncnn3c2)cc1)[C@H](N)C(=O)N1CC[C@H](F)C1 CHEMBL377221 IC50 4.0 nM
N[C@@H](CC(=O)N1CCn2nc(C(F)(F)F)nc2C1Cn1cccn1)Cc1cc(F)c(F)cc1F CHEMBL250351 IC50 4.0 nM
N[C@@H](CC(=O)N1CCn2nc(C(F)(F)F)nc2[C@H]1Cc1ccc(C(F)(F)F)cc1)Cc1cc(F)c(F)cc1F CHEMBL250999 IC50 4.0 nM
N[C@@H](CC(=O)N1CCn2nc(C(F)(F)F)nc2[C@H]1Cc1ccc(F)cc1)Cc1cc(F)c(F)cc1F CHEMBL401304 IC50 4.0 nM
CC#CCn1c(N2CCCC(N)C2)nc2cnn(Cc3nc4ccccc4o3)c(=O)c21 CHEMBL256969 IC50 4.0 nM
CC#CCn1c(N2CCCC(N)C2)nc2cnn(Cc3ccc(C#N)c4ccccc34)c(=O)c21 CHEMBL404220 IC50 4.0 nM
Cc1cc2ncc(C(=O)N3CCC([C@H](N)Cc4cc(F)c(F)cc4F)CC3)c(C)n2n1 CHEMBL484528 IC50 4.0 nM
CN(C[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F)c1ccc(C#N)cn1 CHEMBL552127 IC50 4.0 nM
N[C@@H](CC(=O)N1CCC[C@H]1c1nc(N2CCOCC2)no1)Cc1cc(F)c(F)cc1F CHEMBL585129 IC50 4.0 nM
N[C@@H](CC(=O)N1CCC[C@H]1c1nc(N2CCCC2)no1)Cc1cc(F)c(F)cc1F CHEMBL566616 IC50 4.0 nM
N[C@@H](CC(=O)N1CCC[C@H]1c1nc(-c2ncccn2)no1)Cc1cc(F)c(F)cc1F CHEMBL567727 IC50 4.0 nM
Cc1nc2nc(C(=O)NCc3ccco3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215300 Ki 4.0 nM
N#Cc1ccccc1Cn1c(N2CCC[C@@H](N)C2)cc(=O)[nH]c1=O CHEMBL1650435 IC50 4.0 nM
COc1cnc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O CHEMBL1650411 IC50 4.0 nM
COCCN1Cc2c(nc(C)c(CN)c2-c2ccc(Cl)cc2Cl)C1=O CHEMBL1910114 Ki 4.0 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)CN(CC(=O)O)C2=O CHEMBL1910112 Ki 4.0 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)CN(c1ccc(C#N)cc1)C2=O CHEMBL1910108 Ki 4.0 nM
COc1cccc(C(=O)Cn2cnc3c(C#N)c(N4CCC[C@H](N)C4)n(Cc4ccccc4)c3c2=O)c1 CHEMBL1951423 IC50 4.0 nM
COc1cccc(C(=O)Cn2cnc3c(C#N)c(N4CCC[C@@H](N)C4)n(CC=C(C)C)c3c2=O)c1 CHEMBL1951429 IC50 4.0 nM
CC(C)=CCn1c(N2CCC[C@H](N)C2)c(C#N)c2ncn(Cc3ccnc4ccccc34)c(=O)c21 CHEMBL1951431 IC50 4.0 nM
Cn1c(=O)n(Cc2nccc3ccccc23)c(=O)c2c1c(C#N)c(N1CCC[C@H](N)C1)n2Cc1ccccc1 CHEMBL1951596 IC50 4.0 nM
CC#CCn1c(N2CCC[C@H](N)C2)c(C#N)c2c1c(=O)n(Cc1nccc3ccccc13)c(=O)n2C CHEMBL1951604 IC50 4.0 nM
O=C([C@@H]1C[C@H](N2CCC(c3nnnn3-c3ccccc3)CC2)CN1)N1CCSC1 CHEMBL2147705 IC50 4.0 nM
CS(=O)(=O)c1cccc(-c2cc(N3CC[C@H](c4cc(F)c(F)cc4F)[C@@H](N)C3)ncn2)c1 CHEMBL1234200 Ki 4.0 nM
N#C[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)[C@@H](N)C1CCN(C(=O)c2cnc3ccccc3n2)CC1 CHEMBL2334699 Ki 4.0 nM
N#C[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)[C@@H](N)C1CCN(C(=O)CC2CCCCC2)CC1 CHEMBL2334689 Ki 4.0 nM
CC(C)(C)CC(=O)N1CCC([C@H](N)C(=O)N2[C@H](C#N)C[C@@H]3C[C@@H]32)CC1 CHEMBL2334688 Ki 4.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(Br)cc1 CHEMBL3093896 IC50 4.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(Cl)cc1 CHEMBL3093925 IC50 4.0 nM
Cc1ccc(C[C@H](N)C(=O)N2C[C@@H](F)C[C@H]2C#N)cc1 CHEMBL3093904 IC50 4.0 nM
NC[C@]1(c2cccc(Cl)c2)CC[C@H](n2nc(-c3cccnc3)ccc2=O)CC1 CHEMBL3112960 IC50 4.0 nM
CC1(S(=O)(=O)n2cc3c(n2)CN([C@H]2CCO[C@H](c4cc(F)c(F)cc4F)[C@@H](N)C2)C3)CC1 CHEMBL3654425 IC50 4.0 nM
CC(C)=CCn1c(N2CCCC(N)C2)nc2c1c(=O)n(Cc1ncnc3ccccc13)c(=O)n2C CHEMBL3934913 IC50 4.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(CC(=O)c1cccc3c1OCO3)c(=O)n2C CHEMBL3979864 IC50 4.0 nM
C/C=C/Cn1c(N2CCC[C@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1NC(=O)C(C)C)c(=O)n2C CHEMBL3950914 IC50 4.0 nM
C/C=C/Cn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1NC(=O)C(C)C)c(=O)n2C CHEMBL3926493 IC50 4.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nc(-c3ccccc3)c3ccccc3n1)c(=O)n2C CHEMBL3953094 IC50 4.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2cc(OC)ccc2C(=O)O)c1=O CHEMBL4581959 IC50 4.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1cccc(F)c1 CHEMBL5279581 IC50 4.0 nM
N#C[C@@H]1C[C@H](c2cscn2)CN1C(=O)[C@@H](N)CF CHEMBL5275487 IC50 4.0 nM
N#C[C@@H]1CCCN1C(=O)CNC12CC3CC(CC(C3)C1)C2 CHEMBL5432172 IC50 4.0 nM
CN(C)C(=O)[C@@H](c1ccc(-c2ccc3nncn3c2)cc1)[C@H](N)C(=O)N1CC[C@H](F)C1 CHEMBL207348 IC50 4.1 nM
O=C([C@@H]1C[C@H](N2CCN(c3cccc(Cl)c3)CC2)CN1)N1CCSC1 CHEMBL391577 IC50 4.1 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CC3CC(CC(C3)C1)C2 CHEMBL511785 IC50 4.1 nM
N[C@H]1C[C@@H](N2Cc3cnc(C4CC4)nc3C2)CCO[C@@H]1c1cc(F)ccc1F CHEMBL3654426 IC50 4.1 nM
CS(=O)(=O)c1ccc2c(c1)nc1n2C[C@H](N)[C@@H](c2cc(F)c(F)cc2F)C1 CHEMBL559940 IC50 4.2 nM
Cc1ccc(-c2c(CN)c(CC(C)C)nc3ccc(OCC(N)=O)cc23)cc1 CHEMBL1808464 IC50 4.2 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(CC(N)=O)C2 CHEMBL2441950 Ki 4.2 nM
CS(=O)(=O)n1cc2c(n1)CN([C@@H]1C[C@H](N)[C@@H](c3cc(F)ccc3F)O[C@@H]1C(F)(F)F)C2 CHEMBL4646510 IC50 4.2 nM
Nc1nc(NC2=NC(c3ccccc3)=CC(c3cccc([N+](=O)[O-])c3)O2)nc(N2CCOCC2)n1 CHEMBL5399740 IC50 4.2 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](C(=O)N2CCOCC2)CN1 CHEMBL415647 IC50 4.3 nM
N#Cc1ccc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)cc1 CHEMBL391578 IC50 4.3 nM
C[C@@H]1c2nnc(C(F)(F)F)n2CCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL558779 IC50 4.3 nM
CN(C)C(=O)[C@@H](c1ccc(C2=CN3N=CNC3C=C2)cc1)[C@H](N)C(=O)N1CC[C@H](F)C1 CHEMBL459357 IC50 4.3 nM
CCOC[C@@H]1C(=O)NCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL1779707 IC50 4.3 nM
O=C([C@@H]1C[C@H](N2CCN(c3nnnn3C3CCCCC3)CC2)CN1)N1CCSC1 CHEMBL2147706 IC50 4.3 nM
N[C@H]1C[C@@H](N2Cc3[nH]nc(NC(=O)c4nccs4)c3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL3735129 IC50 4.3 nM
CS(=O)(=O)n1cc2c(n1)CN([C@@H]1C[C@H](N)C(c3cc(F)ccc3F)N(CC(N)=O)C1)C2 CHEMBL3694423 IC50 4.3 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2cc(C(=O)OC)ccc2F)c1=O CHEMBL4876894 IC50 4.3 nM
CC1c2nnc(C(F)(F)F)n2CCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL5266197 IC50 4.3 nM
COc1ccc(Cn2cc(-c3ccc(C[C@H](N)C(=O)N4CCC[C@H]4C#N)cc3)nn2)cc1 CHEMBL2418631 IC50 4.35 nM
N#Cc1ccc(OC[C@H]2CC[C@@H](C(=O)N3CCC[C@H]3C#N)N2)cc1 CHEMBL207650 Ki 4.4 nM
CCNC(=O)[C@@H]1CN[C@H](C(=O)N2CCC[C@H]2C#N)C1 CHEMBL232316 IC50 4.4 nM
CCCc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(=O)O CHEMBL3215820 IC50 4.4 nM
Cc1nc(CN2C(=O)c3c(nc(N4CCC[C@@H](N)C4)n3CC(=O)C3CC3)N3CCN=C23)nc2ccccc12 CHEMBL4464819 IC50 4.41 nM
CCCC[C@H](N)C(=O)N1CCC[C@@H]1B(O)O CHEMBL194852 IC50 4.5 nM
CN(C)C(=O)C[C@@H]1CN[C@H](C(=O)N2CCC[C@H]2C#N)C1 CHEMBL391558 IC50 4.5 nM
CC(C)(CNC(=O)c1ccccc1)NCC(=O)N1C[C@@H](F)C[C@H]1C#N CHEMBL488418 IC50 4.5 nM
O=C([C@@H]1C[C@H](N2CCN(c3nc(-c4ccccc4)cs3)CC2)CN1)N1CCSC1 CHEMBL2147702 IC50 4.5 nM
CCC[C@H](N)C(=O)N1CCC[C@H]1B(O)O CHEMBL3686745 IC50 4.5 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2cccc(C(=O)OC)c2Br)c1=O CHEMBL4852700 IC50 4.5 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](NCc2ccccc2)CN1 CHEMBL195804 IC50 4.6 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2ccc(Br)cc2)N1 CHEMBL380707 Ki 4.6 nM
C[C@@H](C1CCC(c2cccnc2)CC1)[C@H](N)C(=O)N1CCC(F)(F)C1 CHEMBL237151 IC50 4.6 nM
CC(C)(CO)NCC(=O)N1C[C@@H](F)C[C@H]1C#N CHEMBL472096 IC50 4.6 nM
Cc1ccc(-c2c(CN)c(CC(C)(C)C)nc(CC(C)C)c2C(=O)O)cc1 CHEMBL3215606 IC50 4.6 nM
Cn1c(=O)c2c(-c3cc(F)ccc3Br)c(CN)c(N3CCOCC3)nc2n(C)c1=O CHEMBL2159193 IC50 4.6 nM
N[C@@H](CCC(=O)O)C(=S)N1CCC[C@H]1B(O)O CHEMBL3686744 IC50 4.6 nM
Cc1ccc(-c2c(CN)c(CC(C)C)nc3ccc(OCCCCC(=O)O)cc23)cc1 CHEMBL4098936 IC50 4.6 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccc(Br)cc2C(=O)O)c1=O CHEMBL4527363 IC50 4.6 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2cccc(C(=O)NCC)c2)c1=O CHEMBL5268983 IC50 4.6 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2ccn(Cc3ccc4ccc(F)cc4n3)c2c1=O CHEMBL2347036 IC50 4.67 nM
NC(=O)c1cccc(NC(=O)C2=CC[C@H](c3cc(F)c(F)c(F)c3)[C@@H](N)C2)c1 CHEMBL217358 Ki 4.7 nM
CCc1cc(CN2C[C@H](N)[C@H](C(=O)C3CCC[C@H]3C#N)C2)cc(CC)c1C#N CHEMBL429482 IC50 4.7 nM
Cc1nc2nc(C(=O)NCCc3c[nH]cn3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215373 Ki 4.7 nM
Cc1oc(=O)oc1COC(=O)c1ccc2c(c1)c1nc(N3CCC[C@@H](N)C3)n(Cc3cc(F)ccc3Cl)c1c(=O)n2C CHEMBL3400964 IC50 4.7 nM
COc1ccc2c(c1)CCN2[C@@H]1CN[C@H](C(=O)N2CCSC2)C1 CHEMBL388111 IC50 4.8 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](C(=O)N2CCSCC2)CN1 CHEMBL400615 IC50 4.8 nM
CN(C)C(=O)[C@@H]([C@H]1CC[C@H](c2ccc3ncnn3c2)CC1)[C@H](N)C(=O)N1CCC(F)(F)C1 CHEMBL437557 IC50 4.8 nM
N#Cc1cccnc1N1CCN([C@@H]2CN[C@H](C(=O)N3CCC(F)(F)C3)C2)CC1 CHEMBL514011 IC50 4.8 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNC(=O)C1CCCC1)Cc1cc(F)c(F)cc1F CHEMBL557723 IC50 4.8 nM
Cn1c(=O)c2c(nc(N3CCC[C@@H](N)C3)n2Cc2cc(F)ccc2Cl)c2cc(C(=O)O)ccc21 CHEMBL2147069 IC50 4.8 nM
Cn1c(=O)c2c(-c3cc(F)ccc3Br)c(CN)c(N)nc2n(C)c1=O CHEMBL2159188 IC50 4.8 nM
Cc1ccc(O)c(C)c1[C@@H]1CN[C@H](C(=O)N2CCC[C@H]2C#N)C1 CHEMBL413797 IC50 4.9 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](C(=O)N2CCCCC2)CN1 CHEMBL400613 IC50 4.9 nM
CCN(C)C(=O)[C@@H]1CN[C@H](C(=O)N2CCC[C@H]2C#N)C1 CHEMBL234163 IC50 4.9 nM
N[C@@H](CC(=O)N1CC(=O)Nc2ccccc2C1)[C@H]1CCc2cc(F)c(F)cc21 CHEMBL3580776 IC50 4.9 nM
Cn1cnc(S(=O)(=O)n2ncc3c2CN([C@H]2CO[C@H](c4cc(F)ccc4F)[C@@H](N)C2)C3)c1 CHEMBL3735852 IC50 4.9 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2cc(Br)cc(C(=O)O)c2)c1=O CHEMBL4860737 IC50 4.9 nM
Nc1nc(NC2=NC(c3ccccc3)=CC(c3ccc([N+](=O)[O-])cc3)O2)nc(N2CCOCC2)n1 CHEMBL5405820 IC50 4.9 nM
N#C[C@@H]1CSCN1C(=O)C(CCCCN)NC(=O)OCc1ccccc1 CHEMBL92175 Ki 5.0 nM
N#Cc1ccc(N[C@H]2CC[C@H](NCC(=O)N3CCC[C@H]3C#N)CC2)nc1 CHEMBL3084815 IC50 5.0 nM
CC(C)=CCn1c(N2CCCC(N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C CHEMBL365000 IC50 5.0 nM
C#C[C@H]1CC[C@@H](C#N)N1C(=O)CN[C@H]1CC[C@H](Oc2ccc(C#N)cn2)CC1 CHEMBL217040 Ki 5.0 nM
Cn1ncc2nc(N3CCCC(N)C3)n(Cc3ccccc3C#N)c2c1=O CHEMBL1161921 Ki 5.0 nM
NC(=O)c1ccc(OCC2(NCC(=O)c3ccsc3)CCCC2)cc1 CHEMBL541664 IC50 5.0 nM
N#Cc1ccccc1Cn1c(N2CCC[C@@H](N)C2)nc2ccc(Br)cc2c1=O CHEMBL227676 IC50 5.0 nM
N#Cc1ccccc1Cn1c(N2CCC[C@@H](N)C2)nc2ccc(Cl)cc2c1=O CHEMBL389074 IC50 5.0 nM
N#Cc1ccccc1Cn1c(N2CCC[C@@H](N)C2)nc2cccc(F)c2c1=O CHEMBL227464 IC50 5.0 nM
Cn1nc2ccc(N3CC[C@H](c4cc(F)c(F)cc4F)[C@@H](N)C3)nn2c1=O CHEMBL390241 IC50 5.0 nM
N[C@H]1CN(c2ccc3nc(C(F)(F)F)nn3n2)CC[C@@H]1c1cc(F)c(F)cc1F CHEMBL231293 IC50 5.0 nM
N[C@H]1CN(c2cc(-c3cccc(C(=O)O)c3)ncn2)C[C@@H]1c1cc(F)c(F)cc1F CHEMBL236508 IC50 5.0 nM
N[C@@H](CC(=O)N1CCn2nc(C(F)(F)F)nc2C1Cn1cncn1)Cc1cc(F)c(F)cc1F CHEMBL250353 IC50 5.0 nM
CCC1c2nnc(C(F)(F)F)n2CCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL556606 IC50 5.0 nM
CC#CCn1c(N2CCNCC2)nc2cnn(Cc3nc(C)c4ccccc4n3)c(=O)c21 CHEMBL401971 IC50 5.0 nM
CC#CCn1c(N2CCCC(N)C2)nc2cnn(Cc3nc(C)cc4ccccc34)c(=O)c21 CHEMBL256521 IC50 5.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)CCC(=O)N1CCc2ccccc2C1 CHEMBL494146 IC50 5.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)CCC(=O)N1CCn2c(nnc2C(F)(F)F)C1 CHEMBL492733 IC50 5.0 nM
N#Cc1ccc(N2CCC(NCC(=O)N3C[C@@H](F)C[C@H]3C#N)CC2)c(C(F)(F)F)c1 CHEMBL480716 Ki 5.0 nM
CC(=O)N1CC(c2noc([C@@H]3CCCN3C(=O)C[C@H](N)Cc3cc(F)c(F)cc3F)n2)C1 CHEMBL567279 IC50 5.0 nM
CC(C)(CC(=O)N1CCCC1)NCC(=O)N1C[C@@H](F)C[C@H]1C#N CHEMBL1082462 IC50 5.0 nM
Cc1nc2nc(C(=O)NC3CCN(C(C)C)CC3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1214945 Ki 5.0 nM
Cc1nc2nc(C(=O)Nc3nc(-c4cccnc4)cs3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215302 Ki 5.0 nM
CC#Cc1cnc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O CHEMBL1650423 IC50 5.0 nM
C#Cc1cnc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O CHEMBL1650422 IC50 5.0 nM
N#Cc1ccccc1Cn1c(N2CCC[C@@H](N)C2)ncc(-c2cc[nH]c2)c1=O CHEMBL1650420 IC50 5.0 nM
N#Cc1ccccc1Cn1c(N2CCC[C@@H](N)C2)ncc(Br)c1=O CHEMBL1235761 IC50 5.0 nM
CC#CCn1c(N2CCC[C@H](N)C2)c(C#N)c2ncn(Cc3nccc4ccccc34)c(=O)c21 CHEMBL1951428 IC50 5.0 nM
CC#CCn1c(N2CCCNCC2)c(C#N)c2c1c(=O)n(Cc1nccc3ccccc13)c(=O)n2C CHEMBL1951612 IC50 5.0 nM
Cc1cc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)n(-c2ccncc2)n1 CHEMBL2147772 IC50 5.0 nM
Nc1nc(Cl)c2nc[nH]c2n1 CHEMBL226396 IC50 5.0 nM
N#C[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)[C@@H](N)C1CCN(C(=O)c2cnc3ccccc3c2)CC1 CHEMBL2334698 Ki 5.0 nM
CC(C)=CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(C)c(=O)n2C CHEMBL2408773 Activity 5.0 nM
N#Cc1ccc(C[C@H](N)C(=O)N2C[C@@H](F)C[C@H]2C#N)cc1 CHEMBL3093907 IC50 5.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1cccs1 CHEMBL3127984 IC50 5.0 nM
N[C@@H](CC(=O)N1CCc2c(nc(C(F)(F)F)nc2C(F)(F)F)C1)CN1C(=O)CCC(F)(F)[C@@H]1O CHEMBL3644783 IC50 5.0 nM
CC#CCn1c(N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)nc2c1c(=O)n(CC(=O)c1cccc(OC3CC3)c1)c(=O)n2C CHEMBL3680632 IC50 5.0 nM
CC(C)=CCn1c(N2CCCC(N)C2)nc2c1c(=O)n(CC(=O)c1cccc(C(=O)O)c1)c(=O)n2C CHEMBL3965610 IC50 5.0 nM
CNC(=O)c1cccc(C(=O)Cn2c(=O)c3c(nc(N4CCCC(N)C4)n3CC=C(C)C)n(C)c2=O)c1 CHEMBL3897624 IC50 5.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nc(C)cc3ccccc13)c(=O)n2C1CC1 CHEMBL3911930 IC50 5.0 nM
COc1ccc(C[C@H](N)C(=O)N2C[C@@H](F)C[C@H]2C#N)cc1 CHEMBL3093905 IC50 5.0 nM
N#C[C@@H]1C[C@H](c2cccs2)CN1C(=O)[C@@H](N)CF CHEMBL5285902 IC50 5.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1cccc(F)c1C(=O)OC)c(=O)n2C CHEMBL4590999 IC50 5.06 nM
CCCCC(Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)CC(N)Cc2ccccc2F)cc1)C(=O)O CHEMBL365838 IC50 5.1 nM
N[C@H]1Cc2c(ccc3cc(Br)ccc23)O[C@@H]1c1cc(F)c(F)cc1F CHEMBL3979508 IC50 5.17 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN CHEMBL461912 Ki 5.2 nM
CN(C)C(=O)[C@@H](c1ccc(-c2ccc3ncnn3c2)cc1)[C@H](N)C(=O)N1CCCC1 CHEMBL378048 IC50 5.2 nM
O=C([C@@H]1C[C@H](N2CCN(c3ccc(C(F)(F)F)cn3)CC2)CN1)N1CCC(F)(F)C1 CHEMBL474410 IC50 5.2 nM
O=C([C@@H]1C[C@H](N2CCN(c3nc4cccnc4o3)CC2)CN1)N1CCC(F)(F)C1 CHEMBL475586 IC50 5.2 nM
N[C@@H](CC(=O)N1CCNC(=O)[C@H]1CN1CCOCC1)Cc1cc(F)c(F)cc1F CHEMBL1779713 IC50 5.2 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2ccccc2F)cc1 CHEMBL199615 Ki 5.3 nM
CN(C)C(=O)[C@@H](c1ccc(-c2ccn3ncnc3c2)cc1)[C@H](N)C(=O)N1CC[C@H](F)C1 CHEMBL210999 IC50 5.3 nM
Cc1cc(C)c([C@@H]2CN[C@H](C(=O)N3CCC[C@H]3C#N)C2)c(C)c1O CHEMBL389324 IC50 5.3 nM
N[C@H]1C[C@@H](N2Cc3cnc(C4CC4)nc3C2)CC[C@@H]1c1cc(F)c(F)cc1F CHEMBL233563 IC50 5.3 nM
Cc1ncn(-c2ccc(CN3C[C@H](N)[C@H](C(=O)N4CCC[C@H]4C#N)C3)cc2)n1 CHEMBL248794 IC50 5.3 nM
Cc1nnc(-c2ccc(CN3C[C@H](N)[C@H](C(=O)C4[C@H](C#N)CC[C@@H]4F)C3)cc2)o1 CHEMBL249602 IC50 5.3 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)CNC1C2CC3CC1CC(O)(C3)C2 CHEMBL469660 IC50 5.3 nM
CCc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1CC(=O)O CHEMBL1672127 IC50 5.3 nM
CS(=O)(=O)c1cccc(-c2cc(N3C[C@H](c4cc(F)c(F)cc4F)[C@@H](N)C3)ncn2)c1 CHEMBL1232261 Ki 5.3 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CN(Cc2ccc(-n3nccn3)cc2)C[C@@H]1N CHEMBL400338 IC50 5.4 nM
CC(C)(CNC(=O)c1cccs1)NCC(=O)N1C[C@@H](F)C[C@H]1C#N CHEMBL488419 IC50 5.4 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNc1ncccn1)Cc1cc(F)c(F)cc1F CHEMBL564488 IC50 5.4 nM
Cc1cccc(CNCC(=O)c2cn3c(-c4ccc(Cl)cc4Cl)c(CN)c(C)nc3n2)n1 CHEMBL1215374 Ki 5.4 nM
CS(=O)(=O)n1cc2c(n1)CN([C@@H]1C[C@H](N)[C@@H](c3cc(F)ccc3F)[C@@H]3C[C@@H]31)C2 CHEMBL3926627 IC50 5.4 nM
CCC1([C@H](N)C(=O)N2[C@H](C#N)C[C@@H]3C[C@@H]32)CCCC1 CHEMBL3350924 Ki 5.5 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](NC(=O)c2ccccc2)CN1 CHEMBL539939 IC50 5.5 nM
CC(c1ccc(C#N)cc1)N1C[C@H](N)[C@H](C(=O)N2CCC[C@H]2C#N)C1 CHEMBL249601 IC50 5.5 nM
CC(C)=CCn1c(N2CCCNCC2)c(C#N)c2c1c(=O)n(Cc1c(C#N)cnc3ccccc13)c(=O)n2C CHEMBL1949693 IC50 5.5 nM
Cc1ccc(-c2c(/C=C/c3nc(C(=O)O)cs3)c(C)nc(CC(C)C)c2CN)cc1 CHEMBL4097306 IC50 5.5 nM
N[C@H]1C[C@@H](N2CC3=C(C2)CS(=O)(=O)C3)CO[C@@H]1c1cc(F)ccc1F CHEMBL5276430 Ki 5.5 nM
C[C@@H]1N[C@H](C(=O)N2CCC[C@H]2C#N)C[C@@H]1C(=O)N1Cc2ccccc2C1 CHEMBL233127 IC50 5.6 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](C(=O)N2CCCC2)CN1 CHEMBL428369 IC50 5.6 nM
O=C([C@@H]1C[C@H](N2CCC(c3ccccc3)CC2)CN1)N1CCSC1 CHEMBL395606 IC50 5.6 nM
C[C@@H]1N[C@H](C(=O)N2CCC[C@H]2C#N)C[C@@H]1CC(=O)N(C)C CHEMBL430057 IC50 5.6 nM
O=C([C@@H]1C[C@H](N2CCN(c3cnccn3)CC2)CN1)N1CCC(F)(F)C1 CHEMBL474409 IC50 5.6 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNS(=O)(=O)CC(F)(F)F)Cc1cc(F)c(F)cc1F CHEMBL559602 IC50 5.6 nM
COc1ccc(-c2cn3c(-c4ccc(Cl)cc4Cl)c(CN)c(C)nc3n2)cc1 CHEMBL1208900 Ki 5.6 nM
O=C([C@@H]1C[C@H](N2CCC(c3cc(C(F)(F)F)nn3-c3ccccc3)CC2)CN1)N1CCSC1 CHEMBL2147710 IC50 5.6 nM
Cn1c2nc(Cl)cc-2c(N2CCC[C@@H](N)C2)n(Cc2cc(F)ccc2C#N)c1=O CHEMBL3650439 IC50 5.6 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1cc(Cl)ccc1C(=O)OC)c(=O)n2C CHEMBL4458152 IC50 5.61 nM
C=C(C)C[C@@H]1CN[C@H](C(=O)N2CCC[C@H]2C#N)C1 CHEMBL437570 IC50 5.7 nM
CCCNC(=O)[C@@H]1CN[C@H](C(=O)N2CCC[C@H]2C#N)C1 CHEMBL434960 IC50 5.7 nM
N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1CC(F)(F)F)Cc1cc(F)c(F)cc1F CHEMBL536999 IC50 5.7 nM
CC(C)(CNC(=O)c1ccc2[nH]cnc2c1)NCC(=O)N1C[C@@H](F)C[C@H]1C#N CHEMBL519585 IC50 5.7 nM
CCc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(=O)O CHEMBL3216719 IC50 5.7 nM
CCCS(=O)(=O)n1cc2c(n1)CN([C@H]1CO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL3734912 IC50 5.7 nM
Cn1c2nccc-2c(N2CCC[C@@H](N)C2)n(Cc2cc(F)ccc2C#N)c1=O CHEMBL3650433 IC50 5.7 nM
CC#CCn1c(N2CCC[C@H](N)C2)cc(=O)n(Cc2nc(C)c3cc(C)ccc3n2)c1=O CHEMBL4647761 IC50 5.78 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2nc(C)c3cc(C)ccc3n2)c1=O CHEMBL5289102 IC50 5.78 nM
O=C([C@@H]1C[C@H](N2CCc3cc(F)ccc32)CN1)N1CCSC1 CHEMBL223914 IC50 5.8 nM
Cn1c(C(F)(F)F)nc2c1CCN(C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F)C2Cc1ccc(F)cc1 CHEMBL250285 IC50 5.8 nM
CC(C)(CNC(=O)C(C)(C)C)NCC(=O)N1C[C@@H](F)C[C@H]1C#N CHEMBL487861 IC50 5.8 nM
O=C([C@@H]1C[C@H](N2CCN(c3nc4cnccc4o3)CC2)CN1)N1CCC(F)(F)C1 CHEMBL475574 IC50 5.8 nM
Cn1c(=O)c2c(nc(N3CCC[C@@H](N)C3)n2Cc2ccccc2Cl)c2cc(C(=O)O)ccc21 CHEMBL2147082 IC50 5.8 nM
CC#CCn1c(N2CCNCC2)nc2c1c(=O)n(Cc1ncc3ccccc3n1)c(=O)n2C CHEMBL3616900 IC50 5.8 nM
CS(=O)(=O)c1ccc2c3c(ccc2c1)O[C@H](c1cc(F)c(F)cc1F)[C@@H](N)C3 CHEMBL3932825 IC50 5.8 nM
N[C@H]1C[C@@H](N2Cc3cn(S(=O)(=O)C4CC4)nc3C2)CCO[C@@H]1c1cc(F)ccc1F CHEMBL3654423 IC50 5.8 nM
CC(F)(F)C(=O)NC[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL557860 IC50 5.9 nM
N[C@H]1C[C@@H](N2Cc3cnn(-c4ccc(C(F)(F)F)cn4)c3C2)CCO[C@@H]1c1cc(F)ccc1F CHEMBL3654429 IC50 5.9 nM
CCOC(=O)/C=C/OC(=O)[C@@H]1CCCN1C(=O)CNC(=O)OC(C)(C)C CHEMBL5220415 IC50 5.9 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2ccn(Cc3cnc4ccccc4n3)c2c1=O CHEMBL2347037 IC50 5.93 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1c(OC)cccc1C(=O)O)c(=O)n2C CHEMBL4458832 IC50 5.99 nM
C[C@@H](c1ccc(-c2cccc(-c3nn[nH]n3)c2)cc1)[C@H](N)C(=O)N1CC[C@H](F)C1 CHEMBL195378 IC50 6.0 nM
NC(=O)c1cccc(NCC2=CC[C@H](c3cc(F)c(F)c(F)c3)[C@@H](N)C2)c1 CHEMBL274660 Ki 6.0 nM
CCc1nnc2ccc(N3CC[C@H](c4cc(F)c(F)cc4F)[C@@H](N)C3)nn12 CHEMBL390080 IC50 6.0 nM
Cc1nnc2ccc(N3CC[C@H](c4cc(F)c(F)cc4F)[C@@H](N)C3)nn12 CHEMBL231497 IC50 6.0 nM
CCN(CC)C(=O)[C@@H]1CN[C@H](C(=O)N2CCC[C@H]2C#N)C1 CHEMBL393498 IC50 6.0 nM
NC1CN(c2cc(-c3ccsc3)ncn2)CC1c1cc(F)c(F)cc1F CHEMBL536086 Ki 6.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)CCC(=O)N1CCc2ccsc2C1 CHEMBL494340 IC50 6.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)CCC(=O)N1CCn2cc(C(F)(F)F)nc2C1 CHEMBL474048 IC50 6.0 nM
Cc1nc2nc(-c3ccccc3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1209853 Ki 6.0 nM
N#Cc1ccc(F)cc1Cn1c(N2CCC[C@@H](N)C2)ncc(Br)c1=O CHEMBL1650434 IC50 6.0 nM
N#Cc1ccccc1Cn1c(N2CCC[C@@H](N)C2)ncc(/C=C/c2cccnc2)c1=O CHEMBL1650429 IC50 6.0 nM
N#Cc1ccccc1Cn1c(N2CCC[C@@H](N)C2)ncc(I)c1=O CHEMBL1650408 IC50 6.0 nM
N#Cc1ccccc1Cn1c(N2CCC[C@@H](N)C2)ncc(F)c1=O CHEMBL1650404 IC50 6.0 nM
CC(C)C(Oc1ccc(CNC(=O)C2SCCN2C(=O)C[C@H](N)Cc2cc(F)c(F)cc2F)cc1)C(=O)O CHEMBL1683498 IC50 6.0 nM
CNC(=O)c1cc(-c2ccc(Cl)cc2Cl)c(CN)c(C)n1 CHEMBL1688426 IC50 6.0 nM
CC#CCn1c(N2CCCNCC2)c(C#N)c2ncn(Cc3nccc4ccccc34)c(=O)c21 CHEMBL1951438 IC50 6.0 nM
N[C@H]1CN(c2cc(-c3ccccc3)ncn2)CC[C@@H]1c1cc(F)c(F)cc1F CHEMBL2011536 Ki 6.0 nM
N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F CHEMBL393336 IC50 6.0 nM
COCCN1Cc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)c2C1=O CHEMBL2441836 Ki 6.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1ccc(F)cc1F CHEMBL3093913 IC50 6.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1ccc(C(F)(F)F)cc1 CHEMBL3093908 IC50 6.0 nM
Cc1oc(=O)oc1COC(=O)c1ccc2c(c1)c1nc(N3CCC[C@@H](N)C3)n(Cc3ccccc3Cl)c1c(=O)n2C CHEMBL3400963 IC50 6.0 nM
N[C@@H](CC(=O)N1CCc2c(nc(-c3ccco3)nc2C(F)(F)F)C1)CN1C(=O)CCC(F)(F)[C@@H]1O CHEMBL3644788 IC50 6.0 nM
CC#CCn1c(N2CCCC(NC(=O)OC(C)(C)C)C2)nc2c1c(=O)n(Cc1nc(NCc3ccccc3)c3ccccc3n1)c(=O)n2C CHEMBL3680628 IC50 6.0 nM
CC#CCn1c(N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)nc2c1c(=O)n(Cc1cc(C#N)cc3ccccc13)c(=O)n2C CHEMBL3680629 IC50 6.0 nM
CC(C)=CCn1c(N2CCCC(N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1C(=O)N1CCOCC1)c(=O)n2C CHEMBL3957746 IC50 6.0 nM
CC#CCn1c(N2CCCC(N)C2)nc2c1c(=O)n(Cc1cc(=O)n(C)c3ccccc13)c(=O)n2C CHEMBL3986470 IC50 6.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nc(C(F)F)cc3ccccc13)c(=O)n2C CHEMBL3917354 IC50 6.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1-c1ccccc1)c(=O)n2C CHEMBL3948679 IC50 6.0 nM
N[C@@H]1CN(c2ncc(Oc3c[nH]nc3C3=CCC(F)(F)CC3)cn2)C[C@@H]1c1cc(F)c(F)cc1F CHEMBL4642801 IC50 6.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1ccc(N)cc1 CHEMBL5270099 IC50 6.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1ccc(Cl)cc1 CHEMBL5274564 IC50 6.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2cn(Cc3ccc(Cl)cc3)nn2)cc1 CHEMBL2418628 IC50 6.05 nM
N[C@H]1CN(c2cc(-c3ccccc3)ncn2)C(=O)C[C@@H]1c1cc(F)c(F)cc1F CHEMBL376862 Ki 6.1 nM
Cc1cccc(C)c1[C@@H]1CN[C@H](C(=O)N2CCC[C@H]2C#N)C1 CHEMBL396513 IC50 6.1 nM
N[C@@H](CC(=O)N1CCC[C@H]1COc1ccnc(C(F)(F)F)n1)Cc1cc(F)c(F)cc1F CHEMBL557315 IC50 6.1 nM
COc1cc2c3c(ccc2cc1NS(C)(=O)=O)O[C@H](c1cc(F)c(F)cc1F)[C@@H](N)C3 CHEMBL3942843 IC50 6.13 nM
CN(C)C(=O)[C@@H](c1ccc(-c2ccn3ncnc3c2)cc1)[C@H](N)C(=O)N1CCC(F)(F)C1 CHEMBL210829 IC50 6.2 nM
C[C@@H]1N[C@H](C(=O)N2CCC[C@H]2C#N)C[C@@H]1C(=O)N1CCSCC1 CHEMBL394165 IC50 6.2 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CN(Cc2cnc3ccccc3c2)C[C@@H]1N CHEMBL248795 IC50 6.2 nM
CC(C)(CN(Cc1ccc(C#N)cc1)C(=O)c1ccccc1)NCC(=O)N1C[C@@H](F)C[C@H]1C#N CHEMBL471088 IC50 6.2 nM
CC1(NCC(=O)N2C[C@H](F)C[C@@H]2C#N)CCN(S(C)(=O)=O)CC1 CHEMBL456419 IC50 6.2 nM
O=C([C@@H]1CCCN1)N1C[C@@H](O)C[C@H]1B(O)O CHEMBL2063033 IC50 6.2 nM
CC(C)C[C@H](N)C(=O)N1CCSCC1 CHEMBL4250956 IC50 6.29 nM
CN(C)C(=O)[C@@H](c1ccc(-c2ccc3ncnn3c2)cc1)[C@H](N)C(=O)N1CCC(F)(F)C1 CHEMBL209064 IC50 6.3 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](CO)CN1 CHEMBL234356 IC50 6.3 nM
N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cc(F)c(F)cc1F CHEMBL536312 IC50 6.3 nM
CC(C)(F)C(=O)NC[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL558323 IC50 6.3 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNc1ccc(F)cn1)Cc1cc(F)c(F)cc1F CHEMBL556708 IC50 6.3 nM
Cc1cc(N2CCN([C@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)n(-c2ccccc2)n1 CHEMBL2147775 IC50 6.3 nM
Cn1c(=O)c2c(nc(N3CCC[C@@H](N)C3)n2Cc2ccccc2Cl)c2ccc(C#N)cc21 CHEMBL2147072 IC50 6.3 nM
C/C=C/OC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C CHEMBL5219761 IC50 6.39 nM
N#Cc1ccc(CN(Cc2ccc(C#N)cc2)[C@@H]2CN[C@H](C(=O)N3CCSC3)C2)cc1 CHEMBL228021 IC50 6.4 nM
COc1ccc(-c2cc(N3C[C@H](c4cc(F)c(F)cc4F)[C@@H](N)C3)ncn2)cn1 CHEMBL237786 IC50 6.4 nM
CC(C)N1C(=O)CN(C(=O)C[C@H](N)[C@H]2CCc3cc(F)c(F)cc32)Cc2ccccc21 CHEMBL3580791 IC50 6.4 nM
OB(O)[C@@H]1CCCN1C(=S)[C@@H]1CCCN1 CHEMBL3686751 IC50 6.4 nM
O=C([C@@H]1C[C@H](N2CCc3cc(Br)ccc32)CN1)N1CCSC1 CHEMBL223916 IC50 6.5 nM
C[C@@H]1N[C@H](C(=O)N2CCC[C@H]2C#N)C[C@@H]1C(=O)N1CCCC1 CHEMBL393957 IC50 6.5 nM
O=C([C@@H]1CCCN1)N1C[C@H](O)C[C@H]1B(O)O CHEMBL2063034 IC50 6.5 nM
N[C@H](C(=O)N1CC[C@H](F)C1)[C@@H](C(=O)O)c1ccc(-c2ccc(F)cc2)cc1 CHEMBL191327 IC50 6.6 nM
N#Cc1ccc(N[C@H]2CN[C@H](C(=O)N3CCC[C@H]3C#N)C2)nc1 CHEMBL192165 IC50 6.6 nM
C[C@@H]1C(=O)NCCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL385711 IC50 6.6 nM
CC1C(=O)NCCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL390853 IC50 6.6 nM
N[C@H]1C[C@@H](N2Cc3ccccc3C2)CC[C@@H]1c1cc(F)c(F)cc1F CHEMBL392924 IC50 6.6 nM
Cc1csc(NC(=O)c2cn3c(-c4ccc(Cl)cc4Cl)c(CN)c(C)nc3n2)n1 CHEMBL1215090 Ki 6.6 nM
Cc1ccc(-c2c(CN)c(CC(C)C)nc3ccc(CCCCCC(=O)O)cc23)cc1 CHEMBL3216495 IC50 6.6 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccc3cc(Cl)ccc3n2)c1=O CHEMBL2425889 IC50 6.6 nM
CCN(CC)C(=O)CCN1Cc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)c2C1=O CHEMBL2441847 Ki 6.6 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](NS(=O)(=O)c2ccccc2)CN1 CHEMBL193168 IC50 6.7 nM
COC(=O)c1ccc(NC(=O)NC[C@H]2CC[C@@H](C(=O)N3CCC[C@H]3C#N)N2)cc1 CHEMBL210193 Ki 6.7 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CN(Cc2ccc(-c3ccn[nH]3)cc2)C[C@@H]1N CHEMBL249203 IC50 6.7 nM
N[C@H]1Cn2c(nc3cnccc32)C[C@@H]1c1cc(F)c(F)cc1F CHEMBL562188 IC50 6.7 nM
COC(=O)c1ccc(NC(=O)NC[C@H]2CC[C@@H](C(=O)N3CCC[C@H]3CN)N2)cc1 CHEMBL1230763 Ki 6.7 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2ccccc2)N1 CHEMBL206573 Ki 6.8 nM
O=C([C@@H]1C[C@H](N2CCN(c3ccc(C(F)(F)F)cc3)CC2)CN1)N1CCSC1 CHEMBL241245 IC50 6.8 nM
CN(C[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F)C(=O)C(C)(C)C CHEMBL550321 IC50 6.8 nM
COc1cc2c(cc1OC)[C@@H]1C[C@H](N)[C@@H](N3C[C@@H](CF)CC3=O)CN1CC2 CHEMBL591118 IC50 6.8 nM
CS(=O)(=O)n1cc2c(n1)CN([C@H]1CNC(c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL3694421 IC50 6.8 nM
Cc1ccc(-c2c(CN)c(CC(C)C)nc3ccc(OCCCCCC(=O)O)cc23)cc1 CHEMBL4078049 IC50 6.8 nM
N#Cc1ccc(F)cc1Cn1c(N2CCC[C@@H](N)C2)nc2scnc2c1=O CHEMBL4177478 IC50 6.8 nM
CCNc1nc2c(c(-c3cc(F)ccc3Br)c1CN)c(=O)n(C)c(=O)n2C CHEMBL2159191 IC50 6.9 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2cccc(C(=O)NCC(=O)O)c2)c1=O CHEMBL4869930 IC50 6.9 nM
CCC(C)[C@H](N)C(=O)N1CCSCC1 CHEMBL4241366 IC50 6.93 nM
N#C[C@@H]1CCCN1C(=O)CN[C@H]1CC[C@H](Nc2ccc(C(F)(F)F)cn2)CC1 CHEMBL3084816 IC50 7.0 nM
CC[C@@]12C[C@H]3C[C@@H](C1)C[C@@](NCC(=O)N1CCC[C@H]1C#N)(C3)C2 CHEMBL3084812 IC50 7.0 nM
O=C([C@@H]1C[C@H](N2CCc3cc(Cl)ccc32)CN1)N1CCSC1 CHEMBL390512 IC50 7.0 nM
Cc1nc2ccc(N3CC[C@H](c4cc(F)c(F)cc4F)[C@@H](N)C3)nc2c(=O)[nH]1 CHEMBL231395 IC50 7.0 nM
N[C@H]1CN(c2ccc3nccnc3n2)CC[C@@H]1c1cc(F)c(F)cc1F CHEMBL231092 IC50 7.0 nM
CN(C)C(=O)c1cccc(-c2cc(N3CC(N)C(c4cc(F)c(F)cc4F)C3)ncn2)c1 CHEMBL245781 Ki 7.0 nM
N[C@@H](CC(=O)N1CCn2nc(C(F)(F)F)nc2[C@H]1CC1CC1)Cc1cc(F)c(F)cc1F CHEMBL400752 IC50 7.0 nM
CC#CCn1c(N2CCCC(N)C2)nc2c(C)nn(Cc3nc(C)cc4ccccc34)c(=O)c21 CHEMBL255709 IC50 7.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)CCC(=O)N1CCn2cnnc2C1 CHEMBL492536 IC50 7.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)CCC(=O)N1CCCC1 CHEMBL474049 IC50 7.0 nM
COC[C@@H]1CCCN1C(=O)CC[C@H](N)C(=O)N1CCC[C@H]1C#N CHEMBL475465 IC50 7.0 nM
N[C@@H](CC(=O)N1CCC[C@H]1c1nc(C2CC2)no1)Cc1cc(F)c(F)cc1F CHEMBL567278 IC50 7.0 nM
N#Cc1ccccc1Cn1c(N2CCC[C@@H](N)C2)ncc(Cl)c1=O CHEMBL1650405 IC50 7.0 nM
C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccccc1)C(=O)N1CCC[C@H]1B(O)O CHEMBL1765235 IC50 7.0 nM
COc1cc2c(cc1OC)-c1nc(N)c(CN)c(-c3ccc(Cl)cc3Cl)c1C2 CHEMBL122206 IC50 7.0 nM
CC(C)=CCn1c(N2CCCNCC2)c(C#N)c2ncn(Cc3nccc4ccccc34)c(=O)c21 CHEMBL1951437 IC50 7.0 nM
O=C(O)c1c(Cl)ccc(Cl)c1O CHEMBL1233461 IC50 7.0 nM
NC[C@]1(c2cccc(Cl)c2)CC[C@H](N2CCn3c(nnc3C(F)(F)F)C2=O)CC1 CHEMBL3112967 IC50 7.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2cccc(C(=O)OC)c2F)c1=O CHEMBL4871141 IC50 7.0 nM
CC(C)(C)[C@H](N)C(=O)N1[C@H](C#N)C[C@@H]2C[C@@H]21 CHEMBL5398220 Ki 7.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2ccn(Cc3ccc4ccccc4n3)c2c1=O CHEMBL2346926 IC50 7.05 nM
CCC(Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)CC(N)Cc2ccccc2F)cc1)C(=O)O CHEMBL365010 IC50 7.1 nM
CCC(C)(C)[C@H](N)C(=O)N1[C@H](C#N)C[C@@H]2C[C@@H]21 CHEMBL3350920 Ki 7.1 nM
CC(C)N(Cc1ccc(C#N)cc1)[C@@H]1CN[C@H](C(=O)N2CCSC2)C1 CHEMBL227800 IC50 7.1 nM
COc1c(O)ccc(C)c1[C@@H]1CN[C@H](C(=O)N2CCC[C@H]2C#N)C1 CHEMBL244010 IC50 7.1 nM
CS(=O)(=O)Nc1ccc2c(c1)nc1n2C[C@H](N)[C@@H](c2cc(F)c(F)cc2F)C1 CHEMBL561793 IC50 7.1 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNc1ncc(F)cn1)Cc1cc(F)c(F)cc1F CHEMBL549581 IC50 7.1 nM
Cn1cc(CCN2C[C@H](N3Cc4cn[nH]c4C3)C[C@H](N)C2c2cc(F)ccc2F)cn1 CHEMBL3697944 IC50 7.1 nM
Cn1c(C(N)=O)nc2c1CN([C@@H]1C[C@H](N)[C@@H](c3cc(F)ccc3F)O[C@@H]1C(F)(F)F)C2 CHEMBL4644314 IC50 7.1 nM
Cc1ccc(OC[C@H]2CC[C@@H](C(=O)N3CCC[C@H]3C#N)N2)cc1 CHEMBL380894 Ki 7.2 nM
C[C@@H]1c2nnc(C(F)(F)F)n2CCN1C(=O)C[C@H](N)Cc1cc(F)ccc1F CHEMBL217051 IC50 7.2 nM
Cc1ccc(-c2c(COCc3ccc(C(=O)O)cc3)c(C)nc(CC(C)C)c2CN)cc1 CHEMBL4059815 IC50 7.2 nM
CC(C)CN(CC(C)(C)NCC(=O)N1C[C@@H](F)C[C@H]1C#N)C(=O)c1ccccc1 CHEMBL470893 IC50 7.3 nM
N[C@H]1C[C@@H](N2Cc3nn4cccnc4c3C2)CC[C@@H]1c1cc(F)ccc1F CHEMBL3806026 IC50 7.3 nM
N#C[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)[C@@H](N)C1(CO)CCCC1 CHEMBL3350933 Ki 7.4 nM
O=C([C@@H]1C[C@H](N2CCN(c3nc4ccncc4o3)CC2)CN1)N1CCC(F)(F)C1 CHEMBL475573 IC50 7.4 nM
COc1cc(CN2CCN(C(=O)C[C@H](N)Cc3cc(F)c(F)cc3F)CC2=O)c([N+](=O)[O-])cc1OC CHEMBL1779704 IC50 7.4 nM
COC[C@@H]1C(=O)NCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL1779706 IC50 7.4 nM
COC[C@H](C)N1Cc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)c2C1=O CHEMBL2441837 Ki 7.4 nM
CN(C)C(=O)Nc1ccc(S(=O)(=O)N[C@H]2CC[C@H]([C@H](N)C(=O)N3CCSC3)CC2)cc1 CHEMBL3084937 IC50 7.5 nM
CN(C)C(=O)[C@@H](c1ccc(-c2ccc(F)cc2)cc1)[C@H](N)C(=O)N1CCCC1 CHEMBL190466 IC50 7.5 nM
CN(C)C(=O)[C@@H](c1ccc(-c2ccn3nccc3n2)cc1)[C@H](N)C(=O)N1CCC(F)(F)C1 CHEMBL208957 IC50 7.5 nM
CC(c1nc(-c2ccc(S(C)(=O)=O)cc2Cl)no1)[C@H](N)C(F)=C1CCCC1 CHEMBL257023 IC50 7.5 nM
Cc1ccc(-c2c(CN)c(CC(C)C)nc3ccc(CCC(N)=O)cc23)cc1 CHEMBL3216748 IC50 7.5 nM
CC#CCn1c(N2CCCNCC2)c(C#N)c2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C CHEMBL1951613 IC50 7.5 nM
COc1cccc(Cn2cc(-c3ccc(C[C@H](N)C(=O)N4CCC[C@H]4C#N)cc3)nn2)c1 CHEMBL2418630 IC50 7.5 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(C[C@@H]1CCCN1)C2 CHEMBL2441840 Ki 7.5 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccccc2C(=O)O)c1=O CHEMBL4538597 IC50 7.5 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2cn(Cc3cccc(F)c3)nn2)cc1 CHEMBL2418625 IC50 7.56 nM
Cn1c(=O)c2c(-c3cc(F)ccc3Cl)c(CN)c(N)nc2n(C)c1=O CHEMBL2159187 IC50 7.6 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccc(F)cc2C(=O)O)c1=O CHEMBL4438210 IC50 7.6 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](C(N)=O)CN1 CHEMBL232315 IC50 7.7 nM
O=C(CNC1CCCCCC1)N1CCC[C@H]1B(O)O CHEMBL196933 IC50 7.8 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC(C2C3CC4CC(C3)CC2C4)CN1 CHEMBL389138 IC50 7.8 nM
CC(C)NCC(=O)N1C[C@@H](F)C[C@H]1C#N CHEMBL472102 IC50 7.8 nM
CN(C[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F)C(=O)C(C)(F)F CHEMBL559601 IC50 7.8 nM
Cc1ccc(-c2c(CC(=O)N3CCC[C@@H]3C(=O)O)c(C)nc(CC(C)C)c2CN)cc1 CHEMBL3216726 IC50 7.8 nM
N[C@@H](CC(=O)NC1(c2cccc(-c3cncs3)c2)CCS(=O)(=O)CC1)Cc1cc(F)c(F)cc1F CHEMBL2206469 IC50 7.8 nM
O=C([C@@H]1C[C@H](N2CCc3cc([N+](=O)[O-])ccc32)CN1)N1CCSC1 CHEMBL225493 IC50 7.9 nM
N#C[C@@H]1CCCN1C(=O)CNCCNc1ccc([N+](=O)[O-])cn1 CHEMBL77539 IC50 8.0 nM
N#C[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)[C@@H](N)C1(CO)CCCCC1 CHEMBL3350926 Ki 8.0 nM
O=C(CNC12CC3CC(CC(C3)C1)C2)N1CCC[C@@H]1B(O)O CHEMBL373269 IC50 8.0 nM
CN(C)C(=O)[C@@H](c1ccc(-c2ccn3nccc3n2)cc1)[C@H](N)C(=O)N1CC[C@H](F)C1 CHEMBL210459 IC50 8.0 nM
CN(C)C(=O)[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)[C@H](N)C(=O)N1CC[C@H](F)C1 CHEMBL209162 IC50 8.0 nM
C#C[C@H]1CC[C@@H](C#N)N1C(=O)[C@@H](N)CC(C)C CHEMBL217766 Ki 8.0 nM
C#C[C@H]1CC[C@@H](C#N)N1C(=O)[C@@H](N)C1CCCC1 CHEMBL217252 Ki 8.0 nM
C[C@H](c1nc(-c2ccc(NS(C)(=O)=O)cc2Cl)no1)[C@H](N)C(=O)N1CCCC1 CHEMBL386812 IC50 8.0 nM
COc1ccc2nc(N3CCC[C@@H](N)C3)n(Cc3ccccc3C#N)c(=O)c2c1 CHEMBL227670 IC50 8.0 nM
C[C@@H]1C(=O)N(C2CC2)CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL230282 IC50 8.0 nM
CC(C)[C@H](Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)C[C@H](N)Cc2cc(F)c(F)c(F)c2F)cc1)C(=O)O CHEMBL397716 IC50 8.0 nM
Cc1cc(=O)n2nc(N3CC[C@H](c4cc(F)c(F)cc4F)[C@@H](N)C3)ccc2n1 CHEMBL231397 IC50 8.0 nM
N[C@H]1CN(c2ccc3ncnc(C4CC4)c3n2)CC[C@@H]1c1cc(F)c(F)cc1F CHEMBL231295 IC50 8.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1ccc(OC)cc1)c(=O)n2C CHEMBL391307 IC50 8.0 nM
Cn1cnc2cc(C#N)c(-c3ccccc3Cl)c(CN)c21 CHEMBL272114 IC50 8.0 nM
C[C@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)[C@H](N)C(=O)N1CCC[C@H]1C#N CHEMBL475662 IC50 8.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)CCC(=O)N1CCN(C(=O)C(F)(F)F)CC1 CHEMBL474808 IC50 8.0 nM
O=C(CNC12CC3CC(CC(C3)C1)C2)N1CCC[C@H]1B(O)O CHEMBL460842 IC50 8.0 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNS(=O)(=O)c1ccccc1)Cc1cccc(Cl)c1 CHEMBL561322 IC50 8.0 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNS(=O)(=O)C1CC1)Cc1cc(F)c(F)cc1F CHEMBL563272 IC50 8.0 nM
CCS(=O)(=O)c1ccc2c(c1)nc1n2C[C@H](N)[C@@H](c2cc(F)c(F)cc2F)C1 CHEMBL560192 IC50 8.0 nM
CO[C@H]1C[C@H]2C[C@@H](NCC(=O)N3CCC[C@H]3C#N)C[C@H]2C1 CHEMBL1082653 IC50 8.0 nM
Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2cc(F)ccc2Br)c1=O CHEMBL1650440 IC50 8.0 nM
N#Cc1ccc(F)cc1Cn1c(N2CCC[C@@H](N)C2)ncc(Cl)c1=O CHEMBL1650433 IC50 8.0 nM
N#Cc1ccc(F)cc1Cn1c(N2CCC[C@@H](N)C2)ncc(F)c1=O CHEMBL1650432 IC50 8.0 nM
C=Cc1cnc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O CHEMBL1650426 IC50 8.0 nM
Cc1nc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c(=O)c1Br CHEMBL1650406 IC50 8.0 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)CN(c1ccccc1)C2=O CHEMBL1909988 Ki 8.0 nM
CC(C)=CCn1c(N2CCC[C@H](N)C2)c(C#N)c2ncn(Cc3ncc4ccccc4n3)c(=O)c21 CHEMBL1951434 IC50 8.0 nM
N#C[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)[C@@H](N)C1CCN(C(=O)c2cnccn2)CC1 CHEMBL2334697 Ki 8.0 nM
CC(C)=CCn1c(N2CCC[C@H](N)C2)nc2c1c(=O)n(C)c(=O)n2C CHEMBL2408656 Activity 8.0 nM
Cc1nc(CN2C(=O)c3c(nc(N4CCC[C@@H](N)C4)n3CC3CC3)N3CCN=C23)nc2ccccc12 CHEMBL3675627 IC50 8.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1ccc(OC)c3ccccc13)c(=O)n2C CHEMBL3986074 IC50 8.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(C/C=C/c1c(F)c(F)c(F)c(F)c1F)c(=O)n2C CHEMBL3958670 IC50 8.0 nM
COC1C[C@@H]2C[C@H](NCC(=O)N3CCC[C@H]3C#N)C[C@@H]2C1 CHEMBL5273881 IC50 8.0 nM
Cc1ccc(-c2c(CC(=O)Nc3cccc(C(N)=O)c3)c(C)nc(CC(C)C)c2CN)cc1 CHEMBL3216270 IC50 8.1 nM
Cc1nc2c(o1)CN([C@H]1CSC(c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL3644465 IC50 8.1 nM
CC1(S(=O)(=O)n2cc3c(n2)CN([C@H]2CCO[C@H](c4cc(F)ccc4F)[C@@H](N)C2)C3)CC1 CHEMBL3654430 IC50 8.1 nM
CC(C)[C@@H](Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)CC(N)Cc2c(F)c(F)c(F)c(F)c2F)cc1)C(=O)O CHEMBL183289 IC50 8.2 nM
O=C([C@@H]1C[C@H](N2CCN(c3ccc(Br)cc3)CC2)CN1)N1CCSC1 CHEMBL239984 IC50 8.2 nM
CC(C)(CNC(=O)c1ccccn1)NCC(=O)N1C[C@@H](F)C[C@H]1C#N CHEMBL487681 IC50 8.2 nM
O=C([C@@H]1C[C@H](N2CCN(c3nc4ccccc4o3)CC2)CN1)N1CCC(F)(F)C1 CHEMBL515597 IC50 8.2 nM
Cc1ccc(-c2c(CC(=O)Nc3cccc(S(C)(=O)=O)c3)c(C)nc(CC(C)C)c2CN)cc1 CHEMBL3217158 IC50 8.2 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2cn(Cc3cccs3)nn2)cc1 CHEMBL2418639 IC50 8.28 nM
C[C@H]1CC[C@@H](C(=O)N2CCC[C@H]2C#N)N1 CHEMBL210869 Ki 8.3 nM
COc1cc(O)cc(C)c1[C@@H]1CN[C@H](C(=O)N2CCC[C@H]2C#N)C1 CHEMBL243800 IC50 8.3 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](C(=O)N2CCCCCC2)CN1 CHEMBL400614 IC50 8.3 nM
COC12CC3CC(CC(NCC(=O)N4C[C@@H](F)C[C@H]4C#N)(C3)C1)C2 CHEMBL454193 IC50 8.3 nM
C[C@H](NC(=O)[C@@H](N)CCC(=O)O)B(O)O CHEMBL447366 Ki 8.3 nM
N[C@H]1Cn2c(nc3cnccc32)C[C@@H]1c1cc(F)c(F)cc1F CHEMBL552068 IC50 8.3 nM
Nc1nc(NC2=NC(c3ccccc3)=CC(c3ccccc3[N+](=O)[O-])O2)nc(N2CCOCC2)n1 CHEMBL5435689 IC50 8.3 nM
Cn1c(C(F)(F)F)nc2c1CCN(C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F)C2Cc1ccccc1 CHEMBL250284 IC50 8.4 nM
N[C@H]1CN(c2cc(N3CCC(F)(F)C3)ncn2)C[C@@H]1N1CC(F)(F)CCC1=O CHEMBL1683570 IC50 8.4 nM
N#Cc1ccc2c3c(ccc2c1)O[C@@H](c1cc(F)c(F)cc1F)[C@H](N)C3 CHEMBL3920234 IC50 8.42 nM
Cc1nnc(-c2ccc(CN3C[C@H](N)[C@H](C(=O)N4CCC[C@H]4C#N)C3)cc2)o1 CHEMBL399726 IC50 8.5 nM
NC[C@H]1CN(CCc2ccc3c(c2)OCO3)C(=O)C[C@@H]1c1cc(F)ccc1F CHEMBL3236121 IC50 8.5 nM
N#Cc1n[nH]c2c1CN([C@H]1CCO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2 CHEMBL3654421 IC50 8.5 nM
Cc1ccc(-c2c(CCc3nc(C(N)=O)cs3)c(C)nc(CC(C)C)c2CN)cc1 CHEMBL4089615 IC50 8.5 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2cn(Cc3ccc(F)c(F)c3)nn2)cc1 CHEMBL2418632 IC50 8.57 nM
Cc1c(-c2ccc([C@H](C(=O)N(C)C)[C@H](N)C(=O)N3CC[C@H](F)C3)cc2)ccc2ncnn12 CHEMBL209111 IC50 8.6 nM
CC(C)(NCC(=O)N1C[C@@H](F)C[C@H]1C#N)c1ccco1 CHEMBL471089 IC50 8.6 nM
CC(=O)Nc1ccc2c(c1)nc1n2C[C@H](N)[C@@H](c2cc(F)c(F)cc2F)C1 CHEMBL556494 IC50 8.6 nM
Cc1ccn2nc3c(c2n1)CN([C@@H]1CO[C@H](c2cc(F)c(F)cc2F)[C@@H](N)C1)C3 CHEMBL3804940 IC50 8.6 nM
O=C([C@@H]1C[C@H](N2CCN(c3ccc(Cl)cc3)CC2)CN1)N1CCSC1 CHEMBL238507 IC50 8.7 nM
CC(C)OCCCNCC(=O)N1C[C@@H](F)C[C@H]1C#N CHEMBL469452 IC50 8.7 nM
O=C([C@@H]1C[C@H](N2CCN(c3noc4ccccc34)CC2)CN1)N1CCC(F)(F)C1 CHEMBL475246 IC50 8.7 nM
Cc1nc2nc(C(=O)NCCN3CCCCC3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215015 Ki 8.7 nM
Cc1ccc(-c2c(CN)c(CC(C)C)nc3ccc(CCCC(=O)O)cc23)cc1 CHEMBL3215844 IC50 8.7 nM
CC(=O)c1csc(-c2cnc(CC(C)C)c(CN)c2-c2ccc(C)cc2)n1 CHEMBL4096274 IC50 8.7 nM
CN(C)C(=O)[C@@H](c1ccc(-c2ccc3ncnn3c2)cc1)[C@H](N)C(=O)N1CCC(F)(F)C1 CHEMBL537869 IC50 8.8 nM
C[C@]1(N2Cc3cn(S(=O)(=O)NC(=O)OCc4ccccc4)nc3C2)CO[C@H](c2cc(F)ccc2F)[C@@H](N)C1 CHEMBL3970322 IC50 8.8 nM
N[C@H]1C[C@@H](N2Cc3cn(S(=O)(=O)NC(=O)c4ccccc4)nc3C2)CO[C@@H]1c1cc(F)ccc1F CHEMBL4746458 IC50 8.8 nM
CC(C)(C)c1ccccc1OC[C@H]1CC[C@@H](C(=O)N2CCC[C@H]2C#N)N1 CHEMBL210275 Ki 8.9 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](CNc2ccc(Br)cc2)N1 CHEMBL210305 Ki 8.9 nM
CCc1cc(O)cc(C)c1[C@@H]1CN[C@H](C(=O)N2CCC[C@H]2C#N)C1 CHEMBL390418 IC50 8.9 nM
CS(=O)(=O)Nc1ccc2c3c(ccc2c1)O[C@H](c1cc(F)c(F)cc1F)[C@@H](N)C3 CHEMBL3959221 IC50 8.91 nM
N[C@H](C(=O)N1CCSC1)[C@H]1CC[C@H](NC(=O)c2cnc3ccccc3c2)CC1 CHEMBL3084956 IC50 9.0 nM
CN1C(=O)c2nc(N3CCCC(N)C3)n(Cc3ccccc3Cl)c2C1=O CHEMBL1161922 Ki 9.0 nM
C[C@@H]1C(=O)N(C2CC2)CCCN1C(=O)C[C@H](N)Cc1cc(F)ccc1F CHEMBL390885 IC50 9.0 nM
N[C@H]1CN(c2ccc3nnc(C(F)(F)F)n3n2)CC[C@@H]1c1cc(F)c(F)cc1F CHEMBL228311 IC50 9.0 nM
CC#CCn1c(N2CCC[C@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C CHEMBL237288 IC50 9.0 nM
CS(=O)(=O)c1cc(F)cc(-c2cc(N3CC(N)C(c4cc(F)c(F)cc4F)C3)ncn2)c1 CHEMBL246529 Ki 9.0 nM
COCCN(C)c1nc(N)c(CN)c(-c2ccc(Cl)cc2Cl)n1 CHEMBL324777 IC50 9.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)CCC(=O)N1CCn2nc(C(F)(F)F)nc2C1 CHEMBL474047 IC50 9.0 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNC(=O)C1CC1)Cc1cc(F)c(F)cc1F CHEMBL563648 IC50 9.0 nM
CN(C)C(=O)N1C[C@H]2C[C@@H](NCC(=O)N3CCC[C@H]3C#N)C[C@H]2C1 CHEMBL1085269 IC50 9.0 nM
Cc1nc2nc(-c3ccc(Cl)cc3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1208842 Ki 9.0 nM
COc1ccccc1-c1cn2c(-c3ccc(Cl)cc3Cl)c(CN)c(C)nc2n1 CHEMBL1208901 Ki 9.0 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)CN(CCO)C2=O CHEMBL1910113 Ki 9.0 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)CN(c1ccc(F)cc1)C2=O CHEMBL1910107 Ki 9.0 nM
Cc1ccccc1N1Cc2c(nc(C)c(CN)c2-c2ccc(Cl)cc2Cl)C1=O CHEMBL1909993 Ki 9.0 nM
CC(C)=CCn1c(N2CCC[C@H](N)C2)c(C#N)c2ncn(C)c(=O)c21 CHEMBL1951435 IC50 9.0 nM
CC#CCn1c(N2CCCNCC2)c(C#N)c2ncn(Cc3nc(C)c4ccccc4n3)c(=O)c21 CHEMBL1951439 IC50 9.0 nM
CC(C)=CCn1c(N2CCC[C@H](N)C2)c(C#N)c2c1c(=O)n(Cc1cnc3ccccc3n1)c(=O)n2C CHEMBL1951601 IC50 9.0 nM
CC(C)=CCn1c(N2CCC3CNCC32)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C CHEMBL2408655 IC50 9.0 nM
NC[C@]1(c2cccc(Cl)c2)CC[C@H](N2CCc3c(nc(C(F)(F)F)nc3C3CC3)C2)CC1 CHEMBL3112971 IC50 9.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1cc2c(cc1Br)OCO2 CHEMBL3127992 Ki 9.0 nM
CC(C)N(C)C(=O)n1cnc(S(=O)(=O)C2CC3CCC2C3)n1 CHEMBL537586 IC50 9.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1C(=O)N(Cc1ccccc1C#N)C1=NCCN12 CHEMBL3675632 IC50 9.0 nM
CC#CCn1c(N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)nc2c1c(=O)n(Cc1nc(-c3ccccc3)nc3ccccc13)c(=O)n2C CHEMBL3680630 IC50 9.0 nM
CS(=O)(=O)n1cc2c(n1)CN([C@@H]1C[C@H](N)[C@@H](c3cc(F)ccc3F)[C@H]3CC13)C2 CHEMBL3896302 IC50 9.0 nM
CC(C)=CCn1c(N2CCCC(N)C2)nc2c1c(=O)n(Cc1cc3ccccc3cn1)c(=O)n2C CHEMBL3942798 IC50 9.0 nM
CC#CCn1c(N2CCCC(N)C2)nc2c1c(=O)n(Cc1ccnc3ccccc13)c(=O)n2C CHEMBL3985360 IC50 9.0 nM
CN(C)C(=O)[C@@H](c1ccc(-c2ccc(F)cc2)cc1)[C@H](N)C(=O)N1CCSC1 CHEMBL190863 IC50 9.1 nM
CCCCN(Cc1ccc(C#N)cc1)[C@@H]1CN[C@H](C(=O)N2CCSC2)C1 CHEMBL389848 IC50 9.1 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](c2ccccc2O)CN1 CHEMBL245059 IC50 9.1 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccc3cc(C)ccc3n2)c1=O CHEMBL2425891 IC50 9.1 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2cccc(C(=O)NCC(=O)OC)c2)c1=O CHEMBL4874467 IC50 9.1 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2cccc(C(=O)N[C@@H](C)C(=O)O)c2)c1=O CHEMBL4858682 IC50 9.1 nM
N[C@H](C(=O)N1CC[C@H](F)C1)[C@@H](C(=O)N1CCCC1)c1ccc(-c2ccc(F)cc2)cc1 CHEMBL191258 IC50 9.2 nM
Cc1ccc(-c2c(CN)c(CC(C)C)nc3ccc(-c4nn[nH]n4)cc23)cc1 CHEMBL3215634 IC50 9.2 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccc(C(=O)OC)cc2)c1=O CHEMBL4862579 IC50 9.2 nM
COc1cc2c(cc1OC)C1CC(N)C(N3CC(C)CC3=O)CN1CC2 CHEMBL590812 IC50 9.3 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2cn(Cc3ccccc3)nn2)cc1 CHEMBL2418636 IC50 9.39 nM
CC(C)[C@@H](Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)CC(N)Cc2cc(F)c(C(F)(F)F)cc2F)cc1)C(=O)O CHEMBL184177 IC50 9.5 nM
O=C(CNCc1ccccc1)N1CCC[C@H]1B(O)O CHEMBL3686741 IC50 9.5 nM
CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2cn(C/C=C/C(=O)O)nn2)c1=O CHEMBL5289984 IC50 9.56 nM
CN(Cc1ccc(C#N)cc1)[C@@H]1CN[C@H](C(=O)N2CCSC2)C1 CHEMBL227737 IC50 9.6 nM
C[C@@H]1C(=O)N(C(C)(C)C)CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL230283 IC50 9.6 nM
Cc1ccc(-c2c(CN)c(CC(C)C)nc3ccc(CCCCC(=O)O)cc23)cc1 CHEMBL3216279 IC50 9.6 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](N)CN1 CHEMBL191699 IC50 9.7 nM
C[C@H]1CNC(=O)[C@@H](C)N(C(=O)C[C@H](N)Cc2cc(F)c(F)cc2F)C1 CHEMBL230387 IC50 9.7 nM
CN1CCN(c2nc3c(c(-c4cc(F)ccc4Br)c2CN)c(=O)n(C)c(=O)n3C)CC1 CHEMBL2159194 IC50 9.9 nM