N#C[C@@H]1CCCN1C(=O)CNC12CC3CC(CC(O)(C3)C1)C2 CHEMBL142703 IC50 0.12 nM
Cc1nc2nc(C(=O)NCCc3ccccn3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215376 Ki 0.19 nM
Cc1cccc(CNCC(=O)c2cn3c(-c4ccc(Cl)cc4Cl)c(CN)c(C)nc3n2)n1 CHEMBL1215374 Ki 0.28 nM
Cc1nc2nc(C(=O)NCCc3cccnc3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215375 Ki 0.3 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(CCC(=O)O)C2 CHEMBL2441845 Ki 0.3 nM
N=C(N)NCCC[C@H](N)C(=O)N1C[C@@H](O)C[C@H]1B(O)O CHEMBL2063040 IC50 0.31 nM
NCC(=O)N1CCC[C@H]1B(O)O CHEMBL67089 Ki 0.41 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(C[C@@H]1CCCO1)C2 CHEMBL2441839 Ki 0.5 nM
C[C@H](N)C(=O)N1CCC[C@H]1B(O)O CHEMBL63860 Ki 0.53 nM
Cc1nc2nc(C(=O)N(C)CCc3ccccn3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215236 Ki 0.55 nM
Cc1nc2nc(C(=O)N(C)Cc3cccnc3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215167 Ki 0.6 nM
CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O CHEMBL67279 Ki 0.76 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(CC(=O)N1CCCCC1)C2 CHEMBL2441955 Ki 0.8 nM
Cc1nc2nc(C(=O)N3CCN(S(C)(=O)=O)CC3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215087 Ki 0.83 nM
Cc1nc2nc(C(=O)N(C)Cc3ccncc3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215299 Ki 0.86 nM
Cc1cc(NC(=O)c2cn3c(-c4ccc(Cl)cc4Cl)c(CN)c(C)nc3n2)n(C)n1 CHEMBL1215089 Ki 0.9 nM
CCn1nccc1NC(=O)c1cn2c(-c3ccc(Cl)cc3Cl)c(CN)c(C)nc2n1 CHEMBL1215233 Ki 0.9 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(CC(=O)N1CCCC1)C2 CHEMBL2441954 Ki 0.9 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(CC(=O)O)C2 CHEMBL2441844 Ki 0.9 nM
Cc1nc2nc(C(=O)N3COCC3(C)C)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215164 Ki 0.94 nM
Cc1nc2nc(C(=O)N3CCCC3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1214942 Ki 1.0 nM
N[C@H](C(=O)N1Cc2ccccc2C1)C1CCC(O)CC1 CHEMBL5425473 IC50 1.0 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(c1ccn(C)n1)C2 CHEMBL2441831 Ki 1.2 nM
COC[C@H]1CCCN1C(=O)c1cn2c(-c3ccc(Cl)cc3Cl)c(CN)c(C)nc2n1 CHEMBL1215017 Ki 1.3 nM
CCN(CC)C(=O)CN1Cc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)c2C1=O CHEMBL2441846 Ki 1.3 nM
COc1ccc(N2Cc3nc(C)c(CN)c(-c4ccc(Cl)cc4Cl)c3C2=O)cc1 CHEMBL2441829 Ki 1.3 nM
CCN(CC)C(=O)c1cn2c(-c3ccc(Cl)cc3Cl)c(CN)c(C)nc2n1 CHEMBL1214877 Ki 1.4 nM
Cc1nc2nc(C(=O)NC3CCOCC3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1214944 Ki 1.5 nM
CCCN(C)C(=O)CN1Cc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)c2C1=O CHEMBL2441953 Ki 1.8 nM
Cc1nc2nc(C(=O)N3CCNC(=O)C3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215016 Ki 1.9 nM
Cc1nc2nc(C(=O)Nc3nc(-c4cccnc4)cs3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215302 Ki 1.9 nM
COCCN1Cc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)c2C1=O CHEMBL2441836 Ki 1.9 nM
CC(C)[C@H](N)C(=O)N1CCC[C@@H]1B(O)O CHEMBL195189 IC50 2.0 nM
Cc1nc2nc(C(=O)N(C)CCS(C)(=O)=O)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215088 Ki 2.0 nM
Cc1nc2nc(C(=O)NCCc3ccncc3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215448 Ki 2.1 nM
O=C([C@@H]1CCCN1)N1C[C@@H](O)C[C@H]1B(O)O CHEMBL2063033 IC50 2.1 nM
Cc1nc2nc(C(=O)N3CCOCC3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1214943 Ki 2.2 nM
Cc1nc2nc(C(=O)N3CC[C@H](NS(C)(=O)=O)C3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215018 Ki 2.2 nM
COC[C@H](C)N1Cc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)c2C1=O CHEMBL2441837 Ki 2.3 nM
COc1ccccc1N1Cc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)c2C1=O CHEMBL2441830 Ki 2.3 nM
Cc1nc2nc(C(=O)NCc3ncco3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215163 Ki 2.5 nM
Cc1nc2nc(C(=O)Nc3ccon3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215166 Ki 2.5 nM
N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1B(O)O CHEMBL494497 Ki 2.6 nM
CCN(CC)C(=O)CCN1Cc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)c2C1=O CHEMBL2441847 Ki 2.8 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(C[C@@H]1CCCN1S(=O)(=O)C1CC1)C2 CHEMBL2441841 Ki 2.9 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)C1CCCC1 CHEMBL94278 Ki 3.0 nM
CC(C)(C)OC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5cc(F)c(F)cc5C4)(C3)C1)C2 CHEMBL5402430 IC50 3.0 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(C[C@H]1CCCO1)C2 CHEMBL2441838 Ki 3.1 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(CC(=O)N(C)C)C2 CHEMBL2441952 Ki 3.2 nM
CCOC(=O)c1cn2c(-c3ccc(Cl)cc3Cl)c(CN)c(C)nc2n1 CHEMBL1214876 Ki 3.3 nM
Cc1nc2nc(C(=O)NCCc3c[nH]cn3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215373 Ki 3.3 nM
CNC(=O)CN1Cc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)c2C1=O CHEMBL2441951 Ki 3.3 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(c1ccccc1)C2 CHEMBL2441828 Ki 3.4 nM
Cc1csc(NC(=O)c2cn3c(-c4ccc(Cl)cc4Cl)c(CN)c(C)nc3n2)n1 CHEMBL1215090 Ki 3.5 nM
Cc1nc2nc(C(=O)Nc3ccnn3C)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215234 Ki 3.5 nM
Cc1nc2nc(C(=O)NCc3ccco3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215300 Ki 3.5 nM
C[C@H](N)C(=O)N1C[C@@H](O)C[C@H]1B(O)O CHEMBL2063024 IC50 3.5 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(Cc1ccn(C)n1)C2 CHEMBL2441833 Ki 3.7 nM
CC(C)(C)NC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 CHEMBL5398643 IC50 4.0 nM
Cc1cc(CN2Cc3nc(C)c(CN)c(-c4ccc(Cl)cc4Cl)c3C2=O)no1 CHEMBL2441835 Ki 4.3 nM
CCCC[C@H](N)C(=O)N1CCC[C@@H]1B(O)O CHEMBL194852 IC50 4.6 nM
N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)[C@@H](N)CCCCNc1ccc2ccccc2c1 CHEMBL472128 IC50 4.6 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(CC(N)=O)C2 CHEMBL2441950 Ki 5.4 nM
Cc1nc2nc(C(=O)NCc3cccs3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215235 Ki 5.6 nM
Cc1nc2nc(C(=O)Nc3ccn(C)n3)cn2c(-c2ccc(Cl)cc2Cl)c1CN CHEMBL1215165 Ki 5.8 nM
CC[C@@H](C)[C@H](N)C(=O)N1C[C@@H](N=[N+]=[N-])C[C@H]1C#N CHEMBL471547 IC50 6.3 nM
CC(C)(C)[C@H](N)C(=O)N1C[C@@H](O)C[C@H]1B(O)O CHEMBL2063031 IC50 6.4 nM
NCC[C@H](N)C(=O)N1CCC[C@@H]1B(O)O CHEMBL194428 IC50 6.7 nM
CCN(CC)C(=O)[C@@H](C)N1Cc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)c2C1=O CHEMBL2441848 Ki 6.8 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)C(=O)N(Cc1ncco1)C2 CHEMBL2441834 Ki 7.3 nM
O=C([C@@H]1C[C@@H](O)CN1)N1C[C@@H](O)C[C@H]1B(O)O CHEMBL2063035 IC50 9.3 nM
O=C([C@@H]1C[C@H](O)CN1)N1C[C@@H](O)C[C@H]1B(O)O CHEMBL2063037 IC50 9.5 nM
N#Cc1ccc(O[C@H]2CC[C@H](NCC(=O)N3CCC[C@H]3C#N)CC2)nc1 CHEMBL3085037 Ki 10.0 nM
C[C@H](N)C(=O)N1C[C@H](F)C[C@H]1B(O)O CHEMBL2063026 IC50 11.0 nM
CC(C)(C)[C@H](N)C(=O)N1C[C@H](O)C[C@H]1B(O)O CHEMBL2063032 IC50 14.0 nM
O=C(NC(c1ccccc1)c1ccccc1)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5406353 IC50 14.0 nM
CC(C)(C)OC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 CHEMBL5421476 IC50 14.0 nM
O=C(NC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5434105 IC50 20.0 nM
Cc1nc2cc(-c3ccccc3)nn2c(C)c1C(=O)NCC(C)(C)NCC(=O)N1CCC[C@H]1C#N CHEMBL1929394 IC50 21.0 nM
N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)[C@@H](N)CCCCN CHEMBL471731 IC50 25.0 nM
Cc1cc2nc(C)c(C(=O)NCC(C)(C)NCC(=O)N3CCC[C@H]3C#N)c(C)n2n1 CHEMBL1929395 IC50 28.0 nM
Cc1c(C(=O)NCC(C)(C)NCC(=O)N2CCC[C@H]2C#N)cnc2cc(-c3ccccc3)nn12 CHEMBL1929392 IC50 30.0 nM
O=C([C@@H]1C[C@H](N2CCN(c3ccc([N+](=O)[O-])cc3)CC2)CN1)N1CCSC1 CHEMBL391466 IC50 30.0 nM
Cc1ccccc1C[C@@H](N)CC(=O)N1C[C@@H](F)C[C@H]1C#N CHEMBL3330051 IC50 30.0 nM
CC(C)(C)NC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5cc(F)c(F)cc5C4)(C3)C1)C2 CHEMBL5407990 IC50 32.0 nM
N#Cc1ccc(CCC(=O)NC23CC4CC(CC(NCC(=O)N5Cc6ccccc6C5)(C4)C2)C3)cc1 CHEMBL5401924 IC50 32.0 nM
O=C(NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5400525 IC50 33.0 nM
CC[C@H](C)[C@H](N)C(=O)N1C[C@@H](N=[N+]=[N-])C[C@H]1C#N CHEMBL471546 IC50 35.0 nM
N[C@@H](CCC(=O)O)C(=O)N1C[C@@H](O)C[C@H]1B(O)O CHEMBL2063029 IC50 35.0 nM
CO[C@@H]1C[C@H]2C[C@H](NCC(=O)N3CCC[C@H]3C#N)C[C@H]2C1 CHEMBL1082347 IC50 37.0 nM
CO[C@H]1C[C@H]2C[C@H](NCC(=O)N3CCC[C@H]3C#N)C[C@H]2C1 CHEMBL1082348 IC50 37.0 nM
O=C(N[C@H]1CC[C@H](O)CC1)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5405991 IC50 37.0 nM
CC(C)(C)OC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5399745 IC50 37.0 nM
N#Cc1ccc(OC[C@H]2CC[C@@H](C(=O)N3CCC[C@H]3C#N)N2)c(Cl)c1 CHEMBL209940 Ki 39.0 nM
N[C@@H](CCCC(=O)O)C(=O)N1C[C@H](O)C[C@H]1B(O)O CHEMBL2063039 IC50 40.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)C[C@H](N)Cc1ccc(Cl)cc1Cl CHEMBL3330057 IC50 40.0 nM
O=C(NCc1ccccc1)NC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5437013 IC50 40.0 nM
O=C(CNC12CC3CC(C1)CC(NC(=O)C14CC5CC(CC(C5)C1)C4)(C3)C2)N1Cc2ccc(F)cc2C1 CHEMBL5431284 IC50 40.0 nM
Cc1cc2ncc(C(=O)NCC(C)(C)NCC(=O)N3CCC[C@H]3C#N)c(O)n2n1 CHEMBL1929390 IC50 45.0 nM
O=C(NCc1ccc(F)cc1F)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5401877 IC50 48.0 nM
O=C(NC(c1ccc(F)cc1)c1ccc(F)cc1)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5408720 IC50 48.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2ccc(C(=O)O)cc2Cl)N1 CHEMBL379999 Ki 49.0 nM
CS(=O)(=O)c1ccc(OC[C@H]2CC[C@@H](C(=O)N3CCC[C@H]3C#N)N2)c(Cl)c1 CHEMBL210805 Ki 50.0 nM
CC(C)[C@H](N)C(=O)N[C@@H](C)B(O)O CHEMBL365322 Ki 50.0 nM
CC(C)(C)NC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5403872 IC50 50.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)CC(=O)N1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1 CHEMBL362018 IC50 53.0 nM
N[C@@H](CC(=O)N1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)C(=O)N1Cc2ccccc2C1 CHEMBL1814633 IC50 53.0 nM
Cc1nc2cc(C(C)(C)C)nn2c(C)c1C(=O)NCC(C)(C)NCC(=O)N1CCC[C@H]1C#N CHEMBL1929393 IC50 53.0 nM
O=C(CNC12CC3CC(C1)CC(NCC(=O)N1Cc4ccccc4C1)(C3)C2)N1Cc2ccccc2C1 CHEMBL5402025 IC50 55.0 nM
CC(C)c1cc(C(=O)O)ccc1OC[C@H]1CC[C@@H](C(=O)N2CCC[C@H]2C#N)N1 CHEMBL436744 Ki 60.0 nM
Cc1cc2ncc(C(=O)NCC(C)(C)NCC(=O)N3CCC[C@H]3C#N)cn2n1 CHEMBL1929387 IC50 60.0 nM
NCCNC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5423126 IC50 60.0 nM
Cc1cc2ncc(C(=O)NCC(C)(C)NCC(=O)N3CCC[C@H]3C#N)c(C)n2n1 CHEMBL1929388 IC50 64.0 nM
CCCC[C@@H](NC(=O)[C@@H](N)CCCC)B(O)O CHEMBL194249 IC50 65.0 nM
N#Cc1ccc(N2C[C@@H]3[C@H](C2)[C@H]3NCC(=O)N2C[C@@H](F)C[C@H]2C#N)c(Cl)c1 CHEMBL481669 IC50 66.0 nM
Cc1c(C(=O)NCC(C)(C)NCC(=O)N2CCC[C@H]2C#N)cnc2cc(C(C)(C)C)nn12 CHEMBL1929391 IC50 66.0 nM
CN(C)C(=O)[C@@H](c1ccc(-c2ccc(F)cc2)cc1)[C@H](N)C(=O)N1CC[C@H](F)C1 CHEMBL237119 IC50 69.0 nM
CC[C@@H](C)[C@H](N)C(=O)N1Cc2ccc(F)cc2C1 CHEMBL502153 IC50 70.0 nM
O=C(NCc1ccccc1)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5404995 IC50 70.0 nM
N#C[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)[C@@H](N)C12CC3CC(CC(O)(C3)C1)C2 CHEMBL385517 Ki 71.0 nM
NC12CC3CC(C1)CC(NC(=O)OC14CC5CC(CC(NCC(=O)N6Cc7ccccc7C6)(C5)C1)C4)(C3)C2 CHEMBL5399390 IC50 71.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2ccc(C(=O)O)c3ccccc23)N1 CHEMBL380090 Ki 73.0 nM
N[C@H]1CC(CN2CCc3ccccc3C2)=CC[C@@H]1c1cc(F)c(F)c(F)c1 CHEMBL216622 Ki 73.0 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNS(=O)(=O)c1ccccc1)Cc1ccccc1F CHEMBL539187 IC50 80.0 nM
Cc1cc2ncc(C(=O)NCC(C)(C)NCC(=O)N3CCC[C@H]3C#N)c(C(F)(F)F)n2n1 CHEMBL1929389 IC50 81.0 nM
N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)[C@@H](N)CCCCN(c1cccc2ccccc12)c1cccc2ccccc12 CHEMBL518144 IC50 82.0 nM
C[C@@H](c1ccc(-c2ccc(F)cc2)cc1)[C@H](N)C(=O)N1CC[C@H](F)C1 CHEMBL237336 IC50 86.0 nM
N[C@@H](CCC(=O)O)C(=O)N1C[C@H](O)C[C@H]1B(O)O CHEMBL2063030 IC50 86.0 nM
N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)[C@@H](N)CCCCN(c1ccc2ccccc2c1)c1ccc2ccccc2c1 CHEMBL481466 IC50 88.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)CCCN1Cc2ccccc2C1=O CHEMBL1243372 IC50 89.0 nM
O=C(NCc1ccncc1)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5438110 IC50 90.0 nM
O=C([C@@H]1CCCN1)N1C[C@H](O)C[C@H]1B(O)O CHEMBL2063034 IC50 98.0 nM
CC1(NCC(=O)N2C[C@H](F)C[C@@H]2C#N)CCN(S(C)(=O)=O)CC1 CHEMBL456419 IC50 100.0 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNS(=O)(=O)c1ccccc1)Cc1cccc(Cl)c1 CHEMBL561322 IC50 100.0 nM
O=C(NCCCc1ccccc1)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5422425 IC50 100.0 nM
O=C([C@@H]1C[C@H](N2CCN(c3cc(C(F)(F)F)nc4ccccc34)CC2)CN1)N1CCSC1 CHEMBL2058971 IC50 105.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2ccccc2Cl)N1 CHEMBL377390 Ki 107.0 nM
N#Cc1ccc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)nc1 CHEMBL241253 IC50 110.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN CHEMBL461912 IC50 118.0 nM
N#Cc1c(Cl)cccc1N1C[C@@H]2[C@H](C1)[C@H]2NCC(=O)N1C[C@@H](F)C[C@H]1C#N CHEMBL479538 IC50 119.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)C[C@H](N)Cc1ccccc1Cl CHEMBL3330050 IC50 120.0 nM
[N-]=[N+]=NCCCNC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5431503 IC50 120.0 nM
O=C(NCc1ccccn1)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5423199 IC50 120.0 nM
C[C@H](N)C(=O)N1C[C@H](O)C[C@H]1B(O)O CHEMBL2063025 IC50 125.0 nM
N#Cc1ccc(N2C[C@@H]3[C@H](C2)[C@H]3NCC(=O)N2C[C@@H](F)C[C@H]2C#N)c(C(F)(F)F)c1 CHEMBL481288 IC50 130.0 nM
CCCCNC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5438329 IC50 130.0 nM
N#Cc1ccc(N2C[C@@H]3[C@H](C2)[C@H]3NCC(=O)N2C[C@@H](F)C[C@H]2C#N)c(F)c1 CHEMBL479381 IC50 131.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)C[C@H](N)Cc1ccc(I)cc1 CHEMBL3330054 IC50 140.0 nM
O=C(NC12CC3CC(CC(C3)C1)C2)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5408398 IC50 150.0 nM
CCCC[C@@H](NC(=O)[C@@H](N)CCC)B(O)O CHEMBL196180 IC50 160.0 nM
O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2)OCC1c2ccccc2-c2ccccc21 CHEMBL5400483 IC50 160.0 nM
N[C@@H](CCCCNC(=O)OCc1ccc([N+](=O)[O-])cc1)C(=O)N1CCCC1 CHEMBL505629 IC50 168.0 nM
N[C@@H](CCCCNc1ccc2ccccc2c1)C(=O)N1Cc2ccccc2C1 CHEMBL487872 IC50 169.0 nM
N#Cc1cccc(F)c1N1C[C@@H]2[C@H](C1)[C@H]2NCC(=O)N1C[C@@H](F)C[C@H]1C#N CHEMBL481177 IC50 169.0 nM
CC(C)(C)NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5426720 IC50 169.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)C[C@H](N)Cc1ccccc1 CHEMBL3330049 IC50 170.0 nM
O=C(NC12CC3CC(CC(O)(C3)C1)C2)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5394582 IC50 170.0 nM
C[C@H](N)C(=O)N1CC(=O)C[C@H]1B(O)O CHEMBL2063027 IC50 180.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)C[C@H](N)Cc1ccc(F)cc1 CHEMBL3330053 IC50 190.0 nM
N#Cc1cccc(CNC23CC4CC(CC(NCC(=O)N5Cc6ccccc6C5)(C4)C2)C3)c1 CHEMBL5438345 IC50 190.0 nM
O=C(CNC12CC3CC(C1)CC(NC(=O)C14CC5CC(CC(C5)C1)C4)(C3)C2)N1Cc2ccccc2C1 CHEMBL5438620 IC50 190.0 nM
N[C@@H](CCCCNCc1ccccc1)C(=O)N1Cc2ccccc2C1 CHEMBL520200 IC50 200.0 nM
O=C([C@@H]1C[C@@H](O)CN1)N1C[C@H](O)C[C@H]1B(O)O CHEMBL2063036 IC50 200.0 nM
O=C(NCCCCO)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5431471 IC50 200.0 nM
NCCCCNC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5439059 IC50 200.0 nM
O=C(NCCc1ccccc1)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5438248 IC50 200.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)CCCCNC(=O)OCc1ccccc1 CHEMBL471544 IC50 212.0 nM
CCCC[C@@H](NC(=O)[C@@H](N)CC)B(O)O CHEMBL195271 IC50 220.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)C[C@H](N)Cc1ccc(Cl)c(Cl)c1 CHEMBL3330058 IC50 230.0 nM
CC[C@@H](C)[C@H](N)C(=O)N1Cc2ccccc2C1 CHEMBL397070 IC50 240.0 nM
O=C([C@@H]1C[C@H](O)CN1)N1C[C@H](O)C[C@H]1B(O)O CHEMBL2063038 IC50 240.0 nM
C[C@H](NC(=O)[C@@H](N)CCC(N)=O)B(O)O CHEMBL501506 Ki 260.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2cn(Cc3ccc(Cl)c(Cl)c3)nn2)cc1 CHEMBL2418633 IC50 260.0 nM
NC12CC3CC(C1)CC(NCC(=O)N1Cc4ccc(F)cc4C1)(C3)C2 CHEMBL5433274 IC50 260.0 nM
Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)CN(CC(=O)Nc1ccnn1C)C2=O CHEMBL1910125 Ki 262.0 nM
CCCC[C@@H](NC(=O)[C@@H](N)CCCCN)B(O)O CHEMBL194517 IC50 280.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2cn(Cc3ccccc3Cl)nn2)cc1 CHEMBL2418627 IC50 280.0 nM
N#C[C@@H]1CCCN1C(=O)CNC1CCCC1 CHEMBL95089 Ki 293.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2cc(C(=O)O)ccc2Cl)N1 CHEMBL378867 Ki 300.0 nM
COc1cccc(Cn2cc(-c3ccc(C[C@H](N)C(=O)N4CCC[C@H]4C#N)cc3)nn2)c1 CHEMBL2418630 IC50 310.0 nM
COc1cccc2cc(C(=O)N3CCN(C(=O)C[C@H](N)Cc4cc(F)c(F)cc4F)CC3)oc12 CHEMBL2069849 IC50 318.0 nM
CC[C@@H](C)[C@H](N)C(=O)N1CCSC1 CHEMBL191775 IC50 320.0 nM
CC(=O)NC[C@@H]1C[C@@H]2CCCC[C@@H]2N1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL3357775 IC50 320.0 nM
Cc1cc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)n(-c2cccc(F)c2)n1 CHEMBL2147712 IC50 330.0 nM
COc1ccc(Cn2cc(-c3ccc(C[C@H](N)C(=O)N4CCC[C@H]4C#N)cc3)nn2)cc1 CHEMBL2418631 IC50 330.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccccc1 CHEMBL201268 IC50 330.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL3330060 IC50 330.0 nM
CC(C)CCNC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5402378 IC50 330.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2cn(Cc3ccc(Cl)cc3)nn2)cc1 CHEMBL2418628 IC50 340.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2cn(Cc3ccccc3F)nn2)cc1 CHEMBL2418624 IC50 340.0 nM
N#Cc1c(F)cc(N2C[C@@H]3[C@H](C2)[C@H]3NCC(=O)N2C[C@@H](F)C[C@H]2C#N)cc1F CHEMBL520434 IC50 343.0 nM
N#Cc1ccc(N2C[C@@H]3[C@H](C2)[C@H]3NCC(=O)N2C[C@@H](F)C[C@H]2C#N)nc1 CHEMBL519265 IC50 350.0 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNc1ccc(C(F)(F)F)nc1)Cc1cc(F)c(F)cc1F CHEMBL562467 IC50 350.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2cn(Cc3cccc(Cl)c3)nn2)cc1 CHEMBL2417563 IC50 350.0 nM
O=C(CNC12CC3CC(C1)CC(OC(=O)N1CCNCC1)(C3)C2)N1Cc2ccccc2C1 CHEMBL5399929 IC50 350.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2cn(Cc3cccc(F)c3)nn2)cc1 CHEMBL2418625 IC50 360.0 nM
CCCC[C@@H](NC(=O)[C@@H](N)CCCN)B(O)O CHEMBL373319 IC50 400.0 nM
CCC(C)(C)NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5410346 IC50 400.0 nM
CC(C)(C)COC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5427056 IC50 400.0 nM
O=C(NCCF)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5403301 IC50 410.0 nM
O=C(NCC(=O)N1CCC[C@H]1B(O)O)c1cccc2ccccc12 CHEMBL1243373 IC50 420.0 nM
N#Cc1ccc(N2C[C@@H]3[C@H](C2)[C@H]3NCC(=O)N2C[C@@H](F)C[C@H]2C#N)cc1 CHEMBL479380 IC50 421.0 nM
Cn1c(C(=O)N2CCN(C(=O)C[C@H](N)Cc3cc(F)c(F)cc3F)CC2)cc2ccccc21 CHEMBL2069855 IC50 427.0 nM
NC(=O)c1cccc(OCC2=CC[C@H](c3cc(F)c(F)c(F)c3)[C@@H](N)C2)c1 CHEMBL410514 Ki 430.0 nM
CO[C@H]1C[C@H]2C[C@@H](NCC(=O)N3CCC[C@H]3C#N)C[C@H]2C1 CHEMBL1082653 IC50 430.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2cn(Cc3ccc(F)c(F)c3)nn2)cc1 CHEMBL2418632 IC50 440.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2cn(Cc3ccc(F)cc3)nn2)cc1 CHEMBL2418626 IC50 440.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)CN[C@H]1[C@@H]2CN(c3nccs3)C[C@@H]21 CHEMBL479983 IC50 448.0 nM
CC(C)[C@@H](Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)C(N)C2CCCCC2)cc1)C(=O)O CHEMBL183418 IC50 450.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2cn(Cc3cccs3)nn2)cc1 CHEMBL2418639 IC50 450.0 nM
N[C@@H](CC(=O)N1CCC[C@H]1CNS(=O)(=O)CC(F)(F)F)Cc1cc(F)c(F)cc1F CHEMBL559602 IC50 470.0 nM
N[C@@H](CC(=O)N1CCN(C(=O)c2cc(O)c3cccc(O)c3n2)CC1)Cc1cc(F)c(F)cc1F CHEMBL2069853 IC50 471.0 nM
CCCCNC12CC3CC(C1)CC(NCC(=O)N1Cc4ccccc4C1)(C3)C2 CHEMBL5414516 IC50 480.0 nM
CCCCOC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5440616 IC50 489.0 nM
NC(=O)c1cccc(NCC2=CC[C@H](c3cc(F)c(F)c(F)c3)[C@@H](N)C2)c1 CHEMBL274660 Ki 500.0 nM
NCCCC[C@H](N)C(=O)N1Cc2ccccc2C1 CHEMBL488226 IC50 500.0 nM
O=C(CC12CC3CC(CC(O)(C3)C1)C2)NC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 CHEMBL5425364 IC50 500.0 nM
O=C([C@@H]1C[C@H](N2CCc3ccccc32)CN1)N1CCSC1 CHEMBL389244 IC50 501.1 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2cc(C(=O)O)cnc2Cl)N1 CHEMBL377296 Ki 505.0 nM
CCCC[C@@H](NC(=O)[C@@H](N)C(C)C)B(O)O CHEMBL194250 IC50 510.0 nM
O=C([C@@H]1C[C@H](N2CCc3cc(F)ccc32)CN1)N1CCSC1 CHEMBL223914 IC50 518.9 nM
O=C1N[C@H](C(=O)N2CCC[C@H]2B(O)O)C[C@H]1CC(=O)N1Cc2ccccc2C1 CHEMBL1243184 IC50 520.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)CN[C@H]1[C@@H]2CN(c3ncccc3[N+](=O)[O-])C[C@@H]21 CHEMBL480705 IC50 525.0 nM
CC[C@H](C)[C@H](N)C(=O)N1Cc2ccc(F)cc2C1 CHEMBL466590 IC50 540.0 nM
Cc1cc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)n(-c2ccccc2)n1 CHEMBL2147777 IC50 540.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)CN[C@H]1[C@@H]2CN(c3nc4ccccc4s3)C[C@@H]21 CHEMBL480536 IC50 547.0 nM
COc1ccccc1Cn1cc(-c2ccc(C[C@H](N)C(=O)N3CCC[C@H]3C#N)cc2)nn1 CHEMBL2418629 IC50 550.0 nM
N[C@H](C(=O)N1CCSC1)[C@H]1CC[C@H](NC(=O)c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL1682974 IC50 570.0 nM
COc1ccc(Cn2cc(-c3ccc(C[C@H](N)C(=O)N4CCC[C@H]4C#N)cc3)nn2)cc1OC CHEMBL2418634 IC50 600.0 nM
Cc1cc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)n(-c2ccccn2)n1 CHEMBL2147771 IC50 610.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2cn(CCc3ccccc3)nn2)cc1 CHEMBL2418637 IC50 620.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)C[C@H](N)Cc1cccc(F)c1 CHEMBL3330052 IC50 620.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(-c2cn(Cc3ccccc3)nn2)cc1 CHEMBL2418636 IC50 630.0 nM
CCOC(=O)c1ccc(N2C[C@@H]3[C@H](C2)[C@H]3NCC(=O)N2C[C@@H](F)C[C@H]2C#N)cc1 CHEMBL480154 IC50 640.0 nM
O=C(NCC(=O)N1CCC[C@H]1B(O)O)c1cccnc1 CHEMBL2333023 IC50 650.0 nM
N[C@@H](CC(=O)N1CCN(C(=O)c2cccc(-c3ccc(F)cc3)n2)CC1)Cc1cc(F)c(F)cc1F CHEMBL2069858 IC50 658.0 nM
O=C(CN[C@@H]1CCNC1)N1CCC[C@H]1B(O)O CHEMBL4296719 IC50 663.0 nM
COc1ccc2c(c1)CCN2[C@@H]1CN[C@H](C(=O)N2CCSC2)C1 CHEMBL388111 IC50 710.7 nM
N#Cc1ccccc1N1C[C@@H]2[C@H](C1)[C@H]2NCC(=O)N1C[C@@H](F)C[C@H]1C#N CHEMBL471960 IC50 729.0 nM
N#Cc1ccc(CN[C@@H]2CN[C@H](C(=O)N3CCSC3)C2)cc1 CHEMBL223497 IC50 748.7 nM
CC(=O)c1ccc(N2C[C@@H]3[C@H](C2)[C@H]3NCC(=O)N2C[C@@H](F)C[C@H]2C#N)cc1 CHEMBL480914 IC50 771.0 nM
CCCC[C@@H](NC(=O)[C@@H](N)CCN)B(O)O CHEMBL194354 IC50 800.0 nM
CCCC[C@H](NC(=O)[C@@H](N)CCN)B(O)O CHEMBL398076 IC50 800.0 nM
N#Cc1ccc(N2C[C@@H]3[C@H](C2)[C@H]3NCC(=O)N2C[C@@H](F)C[C@H]2C#N)cc1Cl CHEMBL481290 IC50 807.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1ccc(F)cc1F CHEMBL3093913 IC50 870.0 nM
CN(C[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F)S(=O)(=O)C(F)(F)F CHEMBL558452 IC50 880.0 nM
N#C[C@@H]1C[C@@H]2CCC[C@@H]2N1C(=O)C[C@H](N)Cc1ccc(Cl)cc1Cl CHEMBL3330070 IC50 880.0 nM
N[C@@H](CC(=O)N1CCN(C(=O)c2cc3ccccc3o2)CC1)Cc1cc(F)c(F)cc1F CHEMBL2069856 IC50 885.0 nM
N[C@@H](CC(=O)N1CCC[C@H]1c1nc(-c2ccccn2)no1)Cc1cc(F)c(F)cc1F CHEMBL584494 IC50 910.0 nM
NC12CC3CC(C1)CC(NCC(=O)N1Cc4ccccc4C1)(C3)C2 CHEMBL5397234 IC50 910.0 nM
N[C@@H](CC(=O)NC1(c2cccc(-c3cncs3)c2)CCS(=O)(=O)CC1)Cc1cc(F)c(F)cc1F CHEMBL2206469 IC50 940.0 nM
COc1ccc(N2Cc3c(nc(C)c(CN)c3-c3ccc(Cl)cc3Cl)C2=O)cc1 CHEMBL1909989 Ki 971.0 nM
CN(C[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F)c1ccc(C#N)cn1 CHEMBL552127 IC50 990.0 nM
O=C(NCC(=O)N1CCC[C@H]1B(O)O)c1ccncc1 CHEMBL2333025 IC50 1000.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1ccc(F)c(F)c1F CHEMBL3091488 IC50 1000.0 nM