O=C1/C(=C/c2cn(-c3ccccc3)nc2-c2ccc(OCc3ccc(Cl)cc3)cc2)SC(=S)N1CCS(=O)(=O)O CHEMBL565795 IC50 18.0 nM
NS(=O)(=O)c1cc(C(=O)NC2CCSc3ccccc32)ccc1Cl CHEMBL1460470 IC50 65.0 nM
O=C1/C(=C/c2cn(-c3ccccc3)nc2-c2ccc(OCc3ccccc3Cl)cc2)SC(=S)N1CCS(=O)(=O)O CHEMBL567069 IC50 71.0 nM
O=C1/C(=C/c2cn(-c3ccccc3)nc2-c2ccc(OCc3ccccc3F)cc2)SC(=S)N1CCS(=O)(=O)O CHEMBL584481 IC50 74.0 nM
O=C1/C(=C/c2cn(-c3ccccc3)nc2-c2ccc(OCc3ccccc3)cc2)SC(=S)N1CCS(=O)(=O)O CHEMBL565810 IC50 78.0 nM
COc1cc(C(=S)N2CCCCC2)ccc1O CHEMBL1608642 IC50 127.0 nM
NS(=O)(=O)c1ccc(NC(S)=NC2CCCCC2)cc1 CHEMBL1322542 IC50 143.0 nM
COc1ccccc1NS(=O)(=O)c1cc(NC(=O)c2sccc2C)ccc1N1CCCC1 CHEMBL1463248 IC50_Mean 163.0 nM
O=c1/c(=C/c2ccccc2Cl)sc2nc3cc(Br)cnc3n12 CHEMBL1448629 IC50 181.0 nM
COc1ccc(NC(=S)N(CCC(C)C)C2CCN(C(C)C)CC2)cc1Cl CHEMBL1385949 IC50 216.0 nM
CCOC(=O)c1sc2nc3c(SCC(=O)O)cc(C(=O)c4ccccc4O)cn3c(=O)c2c1C CHEMBL1445488 IC50 218.0 nM
COc1cc(C(=S)NCc2ccc(F)c(C(F)(F)F)c2)ccc1O CHEMBL1705741 IC50 220.0 nM
O=C(O)c1ccc(NC(=S)NC(=O)c2ccc(-c3ccc(Br)cc3)o2)cc1 CHEMBL1393151 IC50 226.0 nM
Cc1ccc(-n2c(N)c(C(=O)N3CCN(C)CC3)sc2=S)cc1 CHEMBL1605172 IC50 250.0 nM
CN1CCN(C(=O)c2sc(=S)n(-c3ccccc3)c2N)CC1 CHEMBL1304193 IC50 260.0 nM
O=C1/C(=C/c2cn(-c3ccccc3)nc2-c2ccc(S(=O)(=O)N3CCCCC3)cc2)SC(=S)N1CCS(=O)(=O)O CHEMBL565371 IC50 270.0 nM
O=C(O)c1ccccc1-c1ccc(/C=c2\sc3nc4cc(Br)cnc4n3c2=O)o1 CHEMBL1371869 IC50 308.0 nM
COC(=O)Nc1sc2c(c1C(N)=O)CCC(C)C2 CHEMBL1421970 IC50_Mean 312.0 nM
OCCN1CCN(C(=S)c2ccc(Cl)c(Cl)c2)CC1 CHEMBL1426299 IC50_Mean 339.0 nM
CCN1CCN(C(=S)c2ccc(Cl)cc2)CC1 CHEMBL1410244 IC50_Mean 341.0 nM
S=C(NCCc1ccccc1)Nc1c(Cl)cccc1Cl CHEMBL1408579 IC50 342.0 nM
O=S(=O)(Nc1ccc(Cl)cc1)c1ccc(N2CCOCC2)c(NC(=S)NCCN2CCOCC2)c1 CHEMBL1331149 IC50_Mean 342.0 nM
CCCCCn1c(N)c(-c2nc3ccccc3o2)c2c([N+](=O)[O-])nn(C)c(=O)c21 CHEMBL1381413 IC50_Mean 343.0 nM
Cc1cc(C)c(NC(S)=NCC2CCN(C(C)c3ccccc3)C2)c(C)c1 CHEMBL1353918 IC50_Mean 343.0 nM
O=c1/c(=C/c2ccco2)sc2nc3cc(Br)cnc3n12 CHEMBL1603381 IC50 345.0 nM
O=C(CSc1nc(-c2ccc(F)cc2)nc2c1Cc1ccccc1O2)Nc1cccc(C(=O)O)c1 CHEMBL1370165 IC50_Mean 353.0 nM
CN1CCN(C(=S)C(=O)Nc2ccc(Br)cc2)CC1 CHEMBL1504939 IC50_Mean 386.0 nM
COc1cc(C(=S)NCc2ccc(C)cc2C)ccc1O CHEMBL1727679 IC50 408.0 nM
CCOC(=O)c1sc2nc3c(SCCC(=O)O)cc(C(=O)c4cc(OC)ccc4O)cn3c(=O)c2c1C CHEMBL1536896 IC50 480.0 nM
CCOc1cc(/C=C2/S/C(=N/c3ccc4ccccc4c3)NC2=O)cc(Cl)c1OCC(=O)O CHEMBL1732016 IC50 480.0 nM
O=S(=O)(O)c1cc(O)c2cc(Nc3ccccc3)ccc2c1 CHEMBL1271266 IC50_Mean 485.0 nM
COCCNC(=O)Nc1ccc2nc(-c3ccco3)c(-c3ccco3)nc2c1 CHEMBL1501132 IC50 492.0 nM
COc1ccccc1NS(=O)(=O)c1cc(NC(S)=NCCN2CCOCC2)ccc1N1CCOCC1 CHEMBL1421470 IC50_Mean 498.0 nM
CCOC(=O)N1CCC(N(CCN(C)C)C(S)=Nc2ccc(Oc3ccccc3)cc2)CC1 CHEMBL1540065 IC50_Mean 500.0 nM
O=C(Nc1cc([N+](=O)[O-])ccc1O)c1cccc(C(=O)Nc2cc([N+](=O)[O-])ccc2O)c1 CHEMBL1461216 IC50_Mean 509.0 nM
O=C(O)Cc1cccc(O)c(=O)c1C(=O)O CHEMBL1724282 IC50_Mean 544.0 nM
CCC(CC)c1nnc(NC(=O)c2cc(C(=O)OC)cc([N+](=O)[O-])c2)s1 CHEMBL1540317 IC50_Mean 567.0 nM
Cn1c(=O)[nH]c(=O)c2c1nc(SCCN1CCCCC1)n2CCCc1ccccc1 CHEMBL1569991 IC50_Mean 570.0 nM
Cc1cc(C)c2nc3s/c(=C\c4ccc(-c5ccccc5C(=O)O)o4)c(=O)n3c2c1 CHEMBL1608654 IC50 680.0 nM
CSc1ccc2nc(Nc3nnc(-c4ccc5c(c4)OCCO5)o3)sc2c1 CHEMBL1892801 IC50 682.0 nM
COCCN(C(S)=Nc1c(C)cc(C)cc1C)C(C)c1cccnc1 CHEMBL1314093 IC50_Mean 696.0 nM
Cc1nnc2sc(-c3ccc(NC(=O)c4ccc(-c5ccc(Cl)cc5Cl)o4)cc3)nn12 CHEMBL1350887 IC50_Mean 716.0 nM
S=C(c1ccc(Br)cc1)N1CCN(Cc2ccccc2)CC1 CHEMBL1224683 IC50_Mean 719.0 nM
COc1ccc(NC(S)=NCCN2CCC(C)CC2)cc1Cl CHEMBL1340607 IC50_Mean 720.0 nM
S=C(c1cn(CCOc2ccccc2)c2ccccc12)N1CCCC1 CHEMBL1407203 IC50 727.0 nM
CCOc1ccc(-n2c(SCC(=O)N3CCc4ccccc43)nnc2-c2c[nH]c3ccccc23)cc1 CHEMBL1418840 IC50 730.0 nM
CCN1CCN(C(=S)c2ccc(O)cc2)CC1 CHEMBL1489399 IC50_Mean 740.0 nM
COc1ccc(Cl)cc1N=C(S)N(CCCN1CCOCC1)Cc1cn(C)c2ccccc12 CHEMBL1545441 IC50_Mean 754.0 nM
CCc1ccc(OCC(=O)Nc2ccc(-c3nc4ccccc4o3)c(O)c2)cc1 CHEMBL1329712 IC50_Mean 767.0 nM
Cc1ccc(-n2c(C)nc3oc4ccccc4c(=O)c3c2=O)cc1 CHEMBL1478082 IC50_Mean 779.0 nM
Cc1ccc(-c2nnn3c2nc(NCCc2ccc(S(N)(=O)=O)cc2)c2ccccc23)cc1 CHEMBL1362650 IC50 783.0 nM
O=C(O)c1cc2c(C#Cc3ccc(Oc4ccccc4)cc3)c(-c3ccccc3)oc2cc1O CHEMBL2316908 IC50 800.0 nM
Cc1ccc(NC(=O)c2ccc3nc(N4CCOCC4)sc3c2)c(Cl)c1 CHEMBL1314584 IC50_Mean 804.0 nM
O=S(=O)(O)CCN1N/C(=C/C=C/c2ccccc2)SC1=S CHEMBL565364 Ki 809.0 nM
CCN1CCN(C(=S)c2ccc(Cl)c(Cl)c2)CC1 CHEMBL1485717 IC50_Mean 810.0 nM
NC(=O)C1(N2CCCCC2)CCN(C(S)=Nc2ccc(S(N)(=O)=O)cc2)CC1 CHEMBL1537922 IC50_Mean 811.0 nM
COc1ccc(OC)c(N2C(=O)[C@@H]3C(c4ccccc4Cl)=NO[C@@H]3C2=O)c1 CHEMBL1433062 IC50_Mean 833.0 nM
CCc1ccc(NC2=NC(=O)/C(=C/c3cc(Br)c(OCC(=O)O)c(OC)c3)S2)cc1 CHEMBL1526088 IC50 878.0 nM
Cc1sc2nc(CSC(C)C(=O)Nc3ccc(Cl)cn3)nc(O)c2c1C CHEMBL1888077 IC50_Mean 927.0 nM
CN(C)c1ccc(C(=S)N2CCN(Cc3ccccc3)CC2)cc1 CHEMBL1344075 IC50_Mean 937.0 nM
CCN1CCN(C(=S)c2ccc(Br)cc2)CC1 CHEMBL1405203 IC50_Mean 942.0 nM
Cc1cccc(-n2c(N)c(C(=O)N3CCN(C)CC3)sc2=S)c1 CHEMBL1505246 IC50 960.0 nM
CC1=C(C(=O)OC(C)C)C(c2ccc(Cl)cc2)n2c(sc(=Cc3ccc(OCC(=O)O)cc3)c2=O)=N1 CHEMBL1414679 IC50 967.0 nM
Cc1ccc(C(=S)N2CCN(Cc3ccccc3)CC2)s1 CHEMBL1331139 IC50_Mean 997.0 nM