CCCC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6ccncc6)ccnc5[nH]4)c3c2)c1 CHEMBL4783896 EC50 0.0 nM
O=C1NC(NC23CC4CC(CC(O)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5405059 IC50 0.0 nM
COC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5417147 IC50 0.0 nM
O=C1NC(NC23CC4CC(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5438158 IC50 0.0 nM
O=C1NC(N[C@@H](CO)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5404544 IC50 0.0 nM
CC(C)Oc1ccc(F)c(-c2cnc(N)c(C(=O)Nc3cnccc3N3CCC[C@@H](C(=O)O)C3)n2)c1 CHEMBL4647659 Kd 0.067 nM
CCCCNC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL4644916 Kd 0.075 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CC(F)(F)F CHEMBL5070553 Kd 0.086 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnc2ccc(Br)cn12 CHEMBL393525 Kd 0.09 nM
Cn1cc(-c2ccc3cnc(NC(=O)C4CCN(S(C)(=O)=O)CC4)cc3c2)cn1 CHEMBL5285332 Kd 0.101 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd 0.12 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(Br)cc4F)c3c2s1 CHEMBL2386744 IC50 0.16 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4Br)c3c2s1 CHEMBL2386770 IC50 0.16 nM
CCOC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL4647416 Kd 0.16 nM
CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 CHEMBL4784318 Kd 0.163 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C(C)C CHEMBL4441878 Kd 0.188 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1 CHEMBL2386747 IC50 0.22 nM
CCOC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN)CC1 CHEMBL4645393 Kd 0.22 nM
Cc1nc(NCc2c(F)cccc2F)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5093650 Kd 0.24 nM
CN(C)c1nccc(-c2cnn3ncccc23)n1 CHEMBL4848254 Kd 0.24 nM
O=C1N=C(Nc2c(Cl)cccc2Cl)S/C1=C\c1ccc2nccnc2c1 CHEMBL5081787 Kd 0.252 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5426285 Kd 0.276 nM
CC(C)CN1CCC(C(=O)Nc2cc3cc(-c4cnn(C)c4)ccc3cn2)CC1 CHEMBL5289681 Kd 0.283 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5091238 Kd 0.292 nM
O=c1oc2cc(O)ccc2c2c1[nH]c1ccc(O)cc12 CHEMBL1946917 IC50 0.3 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4OC)c3c2s1 CHEMBL2386745 IC50 0.36 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4F)c3c2s1 CHEMBL3894571 IC50 0.36 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 0.3981 nM
Fc1c(-c2ccncc2)ccc2ncn(-c3ccc4c(c3)OCO4)c12 CHEMBL4764647 Kd 0.5 nM
c1cc(-c2ccc3ncn(-c4ccc5c(c4)OCO5)c3n2)ccn1 CHEMBL4779510 Kd 0.5 nM
COC(=O)c1ccc(-n2cnc3ccc(-c4ccncc4)c(F)c32)cc1 CHEMBL4783719 Kd 0.5 nM
O=C(O)c1ccc(-n2cnc3ccc(-c4ccncc4)nc32)cc1 CHEMBL4752512 Kd 0.5 nM
NC(=O)c1ccc(-n2cnc3ccc(-c4ccncc4)c(F)c32)nc1 CHEMBL4740866 Kd 0.5 nM
Cc1nc2ccc(-c3ccncc3)nc2n1-c1ccc(CN2CCOCC2)cc1 CHEMBL4796768 Kd 0.5 nM
Cc1nc2ccc(-c3ccncc3)nc2n1-c1ccc2c(c1)OCC(=O)N2 CHEMBL4781621 Kd 0.5 nM
CC(=O)N1C[C@@H]2[C@H](C1)[C@H]2n1c(C)nc2ccc(-c3ccncc3)nc21 CHEMBL4757202 Kd 0.5 nM
Cc1nc2ccc(-c3cnn(C4CC4)c3)nc2n1-c1ccc(N2CCOCC2)c(F)c1 CHEMBL4790358 Kd 0.5 nM
CCOC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](C(=O)N(C)C)CC1 CHEMBL4648260 Kd 0.6 nM
O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 CHEMBL1230165 Kd 0.775 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 0.7943 nM
Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1987448 pKi 0.7943 nM
CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]cc(c3c2)-c2cn(nc2C(F)(F)F)CCCC1=O CHEMBL5093741 Kd 0.912 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4F)c3c2s1 CHEMBL2386748 IC50 0.94 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(C)cc4)c3c2s1 CHEMBL2386764 IC50 0.98 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4Cl)c3c2s1 CHEMBL2386746 IC50 0.99 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4F)c3c2s1 CHEMBL3971170 IC50 0.99 nM
CCNC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1992220 pKi 1.0 nM
Nc1nccc(-c2c[nH]c3cnccc23)n1 CHEMBL4079572 IC50 1.0 nM
c1cc(-c2c[nH]c3cnccc23)ccn1 CHEMBL4084955 IC50 1.0 nM
O=C(Nc1ccc(N2CCNCC2)nc1)c1n[nH]cc1/C=C/c1cccnc1 CHEMBL4777426 EC50 1.0 nM
CN1CCC(Oc2ccc(NC(=O)c3n[nH]cc3/C=C/c3cccnc3)cn2)CC1 CHEMBL4799387 EC50 1.0 nM
Cc1n[nH]c2ccc(-c3cncc(N[C@H]4CCNC[C@@H]4F)n3)cc12 CHEMBL4741792 EC50 1.0 nM
Cc1n[nH]c2ccc(-c3cncc(N[C@H]4CC[C@H](O)CC4)n3)cc12 CHEMBL4791039 EC50 1.0 nM
CN(C)C(=O)Nc1cncc(-c2ccc3[nH]nc(C(=O)Nc4cccnc4)c3c2)c1 CHEMBL4750147 EC50 1.0 nM
CN1CCN(c2ccc(NC(=O)c3n[nH]c4ccc(-c5cncc(NC(=O)C6CC6)c5)cc34)cn2)CC1 CHEMBL4742870 EC50 1.0 nM
CN1CCN(Cc2ccc(NC(=O)c3n[nH]c4ccc(-c5cccnc5)cc34)cn2)CC1 CHEMBL4760183 EC50 1.0 nM
O=C(Nc1ccnnc1)c1n[nH]c2ccc(-c3cccnc3)cc12 CHEMBL4746176 EC50 1.0 nM
O=C(Nc1ccc(CN2CCCC2)cc1)c1n[nH]c2ccc(-c3cccnc3F)cc12 CHEMBL4790477 EC50 1.0 nM
COc1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CO)c4)cc23)cn1 CHEMBL4797346 EC50 1.0 nM
CN1CCN(c2ccc(NC(=O)c3n[nH]c4ccc(-c5cncc(CN6CCC(F)(F)C6)c5)cc34)cn2)CC1 CHEMBL4761354 EC50 1.0 nM
O=C(N[C@H]1C[C@@H]1c1ccccc1)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4755660 EC50 1.0 nM
Cc1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCCC5)c4)cc23)cn1 CHEMBL4754606 EC50 1.0 nM
COc1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCCC5)c4)cc23)cn1 CHEMBL4800084 EC50 1.0 nM
CN(C)CCN(C)c1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCCC5)c4)cc23)cn1 CHEMBL4742725 EC50 1.0 nM
NC(=O)c1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCCC5)c4)cc23)cn1 CHEMBL4779592 EC50 1.0 nM
O=C(Nc1ccc(C(=O)N2CCCC2)nc1)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4752625 EC50 1.0 nM
CS(=O)(=O)c1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCCC5)c4)cc23)cn1 CHEMBL4788275 EC50 1.0 nM
O=C(Nc1ccc(N2CCC(O)CC2)nc1)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4756030 EC50 1.0 nM
C[C@@H]1CN(c2ccc(NC(=O)c3n[nH]c4ccc(-c5cncc(CN6CCCCC6)c5)cc34)cn2)C[C@H](C)O1 CHEMBL4794727 EC50 1.0 nM
O=C(Nc1ccnnc1)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4748995 EC50 1.0 nM
O=C(Nc1cnccn1)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4743856 EC50 1.0 nM
Nc1ncc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCCC5)c4)cc23)cn1 CHEMBL4786934 EC50 1.0 nM
O=C(Nc1cccnc1)c1n[nH]c2ccc(-c3cncc(CN4CC5CC(C4)O5)c3)cc12 CHEMBL4743240 EC50 1.0 nM
CC(C)NC(=O)c1n[nH]c2ccc(-c3cncc(NC4CCNCC4)n3)cc12 CHEMBL4762097 EC50 1.0 nM
CN1CCC(n2cc(NC(=O)c3n[nH]c4ccc(-c5cnn(C)c5)cc34)cn2)CC1 CHEMBL4796085 EC50 1.0 nM
Cn1cc(-c2cc3c(C(=O)Nc4ccc(CN5CCCC5)cc4)n[nH]c3cc2F)cn1 CHEMBL4741843 EC50 1.0 nM
Cn1cc(-c2cc3c(C(=O)Nc4ccc(OCCN5CCCC5)cc4)n[nH]c3cc2F)cn1 CHEMBL4756656 EC50 1.0 nM
CN1CCC(Oc2ccc(NC(=O)c3n[nH]c4cc(F)c(-c5cnn(C)c5)cc34)cn2)CC1 CHEMBL4751049 EC50 1.0 nM
CN1CCC(Oc2ncc(NC(=O)c3n[nH]c4cc(F)c(-c5cnn(C)c5)cc34)cc2F)CC1 CHEMBL4778878 EC50 1.0 nM
Cc1cn(-c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)CC(C)C)c6)cc45)nc23)cn1 CHEMBL4747740 EC50 1.0 nM
c1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccnc6)cncc5[nH]4)c3c2)c1 CHEMBL4748515 EC50 1.0 nM
c1cncc(-c2ccc3[nH]nc(-c4cc5cnccc5[nH]4)c3c2)c1 CHEMBL4759361 EC50 1.0 nM
CC(C)C(=O)Nc1cncc(-c2cc3c(-c4cc5cnccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4745415 EC50 1.0 nM
CN1CCC(Oc2ccc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)cc2)CC1 CHEMBL4748484 EC50 1.0 nM
CN1CCN(c2ccc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)cn2)CC1 CHEMBL4800211 EC50 1.0 nM
CN(C)C1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 CHEMBL4741472 EC50 1.0 nM
CN1CCC2(CC1)CN(c1cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn1)C2 CHEMBL4748909 EC50 1.0 nM
CN1CCN(c2ccc(C(=O)Nc3cc4cc(-c5cnn6c5CN(CCF)CC6)ccc4cn3)cn2)CC1 CHEMBL4747563 EC50 1.0 nM
Cn1cncc1-c1ccc2cnc(NC(=O)c3ccc(F)cc3)cc2c1 CHEMBL4783628 EC50 1.0 nM
Cn1cncc1-c1ccc2cnc(NC(=O)c3ccnc(N4CC(N)C4)c3)cc2c1 CHEMBL4780597 EC50 1.0 nM
Cn1cncc1-c1ccc2cnc(NC(=O)c3ccnc(N4CCN(C5CC5)CC4)c3)cc2c1 CHEMBL4758853 EC50 1.0 nM
CN1Cc2ccc(C(=O)Nc3cc4cc(-c5cncn5C)ccc4cn3)cc2C1 CHEMBL4786449 EC50 1.0 nM
Cc1ncc(C(=O)Nc2cc3cc(-c4cnc(C)n4C)ccc3cn2)s1 CHEMBL4800296 EC50 1.0 nM
CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cncs5)ccc4cn3)ccn2)CC1 CHEMBL4744439 EC50 1.0 nM
O=C(Nc1cc2cc(-c3cncs3)ccc2cn1)c1ccc2c(c1)CNCC2 CHEMBL4760089 EC50 1.0 nM
CC(C)Nc1cncc(-c2ccc3cnc(NC(=O)C4CCN(CCF)CC4)cc3c2)n1 CHEMBL4751376 EC50 1.0 nM
CC(C)Nc1cncc(-c2ccc3cnc(NC(=O)c4cccc(C5CCN(C)CC5)c4)cc3c2)n1 CHEMBL4797241 EC50 1.0 nM
O=C(Nc1cc2cc(-c3cncc(NC4CCNCC4)n3)ccc2cn1)C1CC(F)(F)C1 CHEMBL4761487 EC50 1.0 nM
O=C(Nc1cc2cc(-c3cncc(NC4CCNCC4)n3)ccc2cn1)C1CCCCC1 CHEMBL4763112 EC50 1.0 nM
O=C(Nc1cc2cc(-c3cncc(NCC4(F)CNC4)n3)ccc2cn1)C1CC1 CHEMBL4777070 EC50 1.0 nM
O=C(Nc1cc2cc(-c3cncc(N[C@H]4CCNC[C@@H]4F)n3)ccc2cn1)C1CC1 CHEMBL4780537 EC50 1.0 nM
Cc1ncc(C(=O)Nc2cc3nc(-c4cnc(C)n4C)ccc3cn2)s1 CHEMBL4790079 EC50 1.0 nM
CN1CC=C(c2cc(C(=O)Nc3cc4cc(-c5cncc(NC(C)(C)C)n5)cnc4cn3)ccn2)CC1 CHEMBL4800068 EC50 1.0 nM
CC(C)n1cc(C(=O)Nc2cc3cc(-c4cncc(NC5CCN(C)CC5)n4)ncc3cn2)cn1 CHEMBL4785775 EC50 1.0 nM
CN1CCN(c2cc(Nc3ncc4c(-c5ccc6ncccc6c5)c[nH]c4n3)ccn2)CC1 CHEMBL4798969 EC50 1.0 nM
Nc1cc(-c2ccc3ncsc3c2)cc(N)n1 CHEMBL5092882 IC50 1.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CCOc1ccccc1 CHEMBL5088511 IC50 1.0 nM
Cc1oc2ccc(-c3cc(N)nc(N)c3)cc2c1C CHEMBL5073869 IC50 1.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2ncoc2c1 CHEMBL5438293 IC50 1.0 nM
CCOC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5409730 IC50 1.0 nM
O=C1NC(N[C@H]2C3CC4CC2C[C@](O)(C4)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5428651 IC50 1.0 nM
O=C1NC(NC23CC4CC(CC2C4)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5400230 IC50 1.0 nM
O=C1NC(NC23CC4(F)CC(F)(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5422486 IC50 1.0 nM
CC(=O)NC12CC3CC(C1)CC(NC1=N/C(=C\c4ccc5ncsc5c4)C(=O)N1)(C3)C2 CHEMBL5422654 IC50 1.0 nM
O=C1NC(NC23CC4CC(CC(NC(=O)C5CC5)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5418722 IC50 1.0 nM
CS(=O)(=O)NC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5409574 IC50 1.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4)c3c2s1 CHEMBL2386762 IC50 1.13 nM
CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]c(F)c(c3c2)-c2cn(nc2C(F)(F)F)CCCC1=O CHEMBL5086263 Kd 1.163 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1C CHEMBL5085086 IC50 1.2 nM
COC1=CC2C(=O)NC3=Cc4ccc(OC)cc4C(=C1OC)C32 CHEMBL5279705 Kd 1.38 nM
O=C1CCCc2[nH]c3c(Cl)cccc3c21 CHEMBL5203393 IC50 1.6 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc5c(c4)OCO5)c3c2s1 CHEMBL2386753 IC50 1.65 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccccc4)c3c2s1 CHEMBL2386763 IC50 1.81 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 EC50 2.0 nM
Cc1n[nH]c2ccc(-c3cncc(O[C@H]4CCNCC4(F)F)n3)cc12 CHEMBL4764315 EC50 2.0 nM
O=C(Nc1cccnc1)c1n[nH]c2ccc(-c3cncc(NC(=O)N4CCOCC4)c3)cc12 CHEMBL4790121 EC50 2.0 nM
O=C(Nc1cccnc1)c1n[nH]c2ccc(-c3cncc(CN4CC(CO)(CO)C4)c3)cc12 CHEMBL4780576 EC50 2.0 nM
CN(C)Cc1cncc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCC5)c4)cc23)c1 CHEMBL4795039 EC50 2.0 nM
COc1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCC5)c4)cc23)cn1 CHEMBL4799007 EC50 2.0 nM
COc1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCC(F)(F)C5)c4)cc23)cn1 CHEMBL4779515 EC50 2.0 nM
O=C(NCc1cc(F)cc(F)c1)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4764842 EC50 2.0 nM
Cc1cncc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCCC5)c4)cc23)c1 CHEMBL4776499 EC50 2.0 nM
O=C(Nc1ccc(N2CC(CO)(CO)C2)nc1)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4782319 EC50 2.0 nM
CC1CCN(Cc2cncc(-c3ccc4[nH]nc(C(=O)Nc5cccnc5)c4c3)c2)CC1 CHEMBL4785547 EC50 2.0 nM
O=C(Nc1cnccn1)c1n[nH]c2ccc(-c3cncc(CN4CCCCCC4)c3)cc12 CHEMBL4747741 EC50 2.0 nM
O=C(Nc1cccnc1)c1n[nH]c2ccc(-c3cncc(CN4CCS(=O)(=O)CC4)c3)cc12 CHEMBL4764569 EC50 2.0 nM
CN1CCC(Nc2ccc(NC(=O)c3n[nH]c4cc(F)c(-c5cnn(C)c5)cc34)cn2)CC1 CHEMBL4794020 EC50 2.0 nM
Cn1cc(-c2cc3c(C(=O)Nc4ccc5c(c4)CNC5)n[nH]c3cc2F)cn1 CHEMBL4744452 EC50 2.0 nM
CC(C)CC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccc(F)c6)cncc5[nH]4)c3c2)c1 CHEMBL4757954 EC50 2.0 nM
CN1CCN(c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cccnc6)cc45)nc23)CC1 CHEMBL4751115 EC50 2.0 nM
CN1CCN(c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(N7CCOCC7)c6)cc45)nc23)CC1 CHEMBL4760982 EC50 2.0 nM
c1cncc(-c2ccc3[nH]nc(-c4nc5c(N6CCOCC6)cncc5[nH]4)c3c2)c1 CHEMBL4782737 EC50 2.0 nM
Cc1cn(-c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)C(C)(C)C)c6)nc45)nc23)cn1 CHEMBL4757581 EC50 2.0 nM
CCNCc1cncc(-c2cc3c(-c4nc5c(-c6ccsc6)nccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4755887 EC50 2.0 nM
Cc1ccc(-c2nccc3[nH]c(-c4n[nH]c5ccc(-c6cncc(N)c6)nc45)nc23)s1 CHEMBL4778742 EC50 2.0 nM
Cc1ccc(-c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(N)c6)nc45)nc23)s1 CHEMBL4754110 EC50 2.0 nM
CN1CCC(Oc2ccc3[nH]c(-c4n[nH]c5ccc(-c6cnn(C)c6)cc45)nc3c2)CC1 CHEMBL4744523 EC50 2.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccnc6)nccc5[nH]4)c3c2)c1 CHEMBL4749420 EC50 2.0 nM
CCNCc1cncc(-c2cc3c(-c4cc5c(-c6cccnc6)cncc5[nH]4)n[nH]c3cn2)c1 CHEMBL4750750 EC50 2.0 nM
c1cncc(-c2cc3c(-c4cc5cnccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4747558 EC50 2.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4cc5cccnc5[nH]4)c3c2)c1 CHEMBL4755073 EC50 2.0 nM
CCC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5cnccc5[nH]4)c3c2)c1 CHEMBL4755477 EC50 2.0 nM
CCCCC(=O)Nc1cncc(-c2cc3c(-c4cc5cnccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4746788 EC50 2.0 nM
CC(C)(C)CC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5cnccc5[nH]4)c3c2)c1 CHEMBL4752468 EC50 2.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4cc5cnccc5[nH]4)c3c2)c1)C1CCC1 CHEMBL4797292 EC50 2.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4cc5cnccc5[nH]4)c3c2)c1)C1CCCCC1 CHEMBL4779458 EC50 2.0 nM
O=C(Nc1cncc(-c2cnc3[nH]nc(-c4cc5cnccc5[nH]4)c3c2)c1)c1ccccc1 CHEMBL4751252 EC50 2.0 nM
CN(C)Cc1ccc(C(=O)Nc2cc3cc(-c4cnn(C)c4)ccc3cn2)cc1 CHEMBL4755642 EC50 2.0 nM
CN(C)CCNc1cc(C(=O)Nc2cc3cc(-c4cnn(C)c4)ccc3cn2)ccn1 CHEMBL4755182 EC50 2.0 nM
CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)c(F)cc4cn3)ccn2)CC1 CHEMBL4778468 EC50 2.0 nM
Cn1cc(-c2ccc3cnc(NC(=O)c4ccnc(N5CC6CC5CN6)c4)cc3c2)cn1 CHEMBL4791671 EC50 2.0 nM
CN1CCCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 CHEMBL4789887 EC50 2.0 nM
CN1CCN(c2cc(CC(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 CHEMBL4759886 EC50 2.0 nM
CN1CCN(c2ccc(C(=O)N3CCN(c4cc(C(=O)Nc5cc6cc(-c7cnn(C)c7)ccc6cn5)ccn4)CC3)cn2)CC1 CHEMBL4764269 EC50 2.0 nM
CN1CCC(Nc2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 CHEMBL4743755 EC50 2.0 nM
Cn1cc(-c2ccc3cnc(NC(=O)c4ccc5c(c4)CNCC5)cc3c2)cn1 CHEMBL4745735 EC50 2.0 nM
Cn1cc(-c2ccc3cnc(NC(=O)c4ccc5c(cnn5C)c4)cc3c2)cn1 CHEMBL4752070 EC50 2.0 nM
CN1CCC(n2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)cn2)CC1 CHEMBL4761662 EC50 2.0 nM
CN(C)C1CN(c2ncc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)s2)C1 CHEMBL4762838 EC50 2.0 nM
CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5N)ccc4cn3)ccn2)CC1 CHEMBL4793867 EC50 2.0 nM
CN1CCC2(CC1)CN(c1cc(C(=O)Nc3cc4cc(-c5cnn(C)c5CO)ccc4cn3)ccn1)C2 CHEMBL4762392 EC50 2.0 nM
CO[C@H]1CC[C@H](C(=O)Nc2cc3cc(-c4cnn(C)c4CN4CCCCC4)ccc3cn2)CC1 CHEMBL4763084 EC50 2.0 nM
Cn1ncc(-c2ccc3cnc(NC(=O)c4cccc(CN5CCCC5)c4)cc3c2)c1CN1CCCCC1 CHEMBL4740518 EC50 2.0 nM
Cn1ncc(-c2ccc3cnc(NC(=O)c4ccnc(N5CCOCC5)c4)cc3c2)c1CN1CCOCC1 CHEMBL4782826 EC50 2.0 nM
CNC(=O)c1ccc(C(=O)Nc2cc3cc(-c4cn(C)nn4)ccc3cn2)cn1 CHEMBL4790614 EC50 2.0 nM
CN1CCc2cc(C(=O)Nc3cc4cc(-c5cn(C)nn5)ccc4cn3)ccc2C1 CHEMBL4777663 EC50 2.0 nM
CC(C)n1cc(C(=O)Nc2cc3cc(-c4cncn4C)ccc3cn2)cn1 CHEMBL4755579 EC50 2.0 nM
NC1CN(c2cc(C(=O)Nc3cc4cc(-c5cnco5)ccc4cn3)ccn2)C1 CHEMBL4741620 EC50 2.0 nM
Cc1nnc(-c2ccc3cnc(NC(=O)c4ccnc(N(C)C5CCN(C)CC5)c4)cc3c2)s1 CHEMBL4788867 EC50 2.0 nM
O=C(Nc1cc2cc(-c3cncc(NCC4(F)CNC4)n3)ncc2cn1)C1CC1 CHEMBL4741309 EC50 2.0 nM
CN1CCCCN(C)c2nccc3[nH]c(nc23)-c2c[nH]c3ccc(cc23)-c2cncc(c2)C1 CHEMBL4741101 EC50 2.0 nM
Nc1cc(-c2ccn3nccc3n2)cc(N)n1 CHEMBL5081583 IC50 2.0 nM
CCCCn1c(C)nc2ccc(-c3cc(N)nc(N)c3)nc21 CHEMBL5082456 IC50 2.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CCOc1cccc(Br)n1 CHEMBL5089171 IC50 2.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5420724 IC50 2.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2[nH]cnc2c1 CHEMBL5404416 IC50 2.0 nM
Cn1cc2cc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)ccc2n1 CHEMBL5408531 IC50 2.0 nM
C[C@@H]1[C@H]2C[C@@H](C[C@H]1NC1=N/C(=C\c3ccc4ncsc4c3)C(=O)N1)C2(C)C CHEMBL5416470 IC50 2.0 nM
CC1(C)C2CCC1(C)[C@H](NC1=N/C(=C\c3ccc4ncsc4c3)C(=O)N1)C2 CHEMBL5412900 IC50 2.0 nM
O=C1NC(NC2CCCCC(F)(F)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5396550 IC50 2.0 nM
CCOc1ccccc1CNc1nc(C)nc2[nH]cc(-c3ccnc(N)c3)c12 CHEMBL4294976 IC50 2.1 nM
O=C(O)c1nc2ccccc2c2[nH]c3c(I)cccc3c12 CHEMBL3589662 IC50 2.3 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 2.512 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 2.512 nM
CNC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2005509 pKi 2.512 nM
Oc1ccc(-c2n[nH]c3ncc(-c4ccc(O)c(O)c4)cc23)cc1 CHEMBL4873449 Kd 2.541 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1nccc(-c2cn(C)c3cnccc23)n1 CHEMBL3421968 Kd 2.573 nM
O=C1NC(NC2CCCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5283849 Kd 2.602 nM
COC(=N)c1nc2ccc3ncnc(Nc4cc(Br)c5c(c4)OCO5)c3c2s1 CHEMBL3915647 IC50 2.76 nM
C[C@@H]1CN(C(=O)Nc2cc(-c3cn([C@H]4CC[C@@](C)(O)CC4)c4cnccc34)ccn2)C[C@H](C)O1 CHEMBL4640031 IC50 3.0 nM
CC(C)CCNC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL4644064 EC50 3.0 nM
CN1CCN(c2ccc(NC(=O)c3n[nH]c4ccc(-c5cncc(NC(=O)c6c(F)cccc6F)c5)cc34)cn2)CC1 CHEMBL4745311 EC50 3.0 nM
O=C(Nc1ccc(N2CCCC2)nc1)c1n[nH]c2ccc(-c3cncc(CN4CCC4)c3)cc12 CHEMBL4800437 EC50 3.0 nM
O=C(Nc1ccc2c(c1)OCCO2)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4758259 EC50 3.0 nM
Cc1ncc(NC(=O)c2n[nH]c3ccc(-c4cnn(C5CCN(C)CC5)c4)cc23)s1 CHEMBL4777667 EC50 3.0 nM
Cc1cc(-c2ccc3[nH]nc(C(=O)Nc4ccc(OC5CCN(C)CC5)cc4)c3c2)sn1 CHEMBL4789136 EC50 3.0 nM
CC(C)(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5ccncc5[nH]4)c3c2)c1 CHEMBL4783807 EC50 3.0 nM
NC1CN(c2cncc(-c3ccc4[nH]nc(-c5nc6ccncc6[nH]5)c4c3)n2)C1 CHEMBL4747703 EC50 3.0 nM
c1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccoc6)cncc5[nH]4)c3c2)c1 CHEMBL4749618 EC50 3.0 nM
CC(C)CC(=O)Nc1cncc(-c2cc3c(-c4nc5c(-c6cc(F)cc(OCCN7CCCC7)c6)cncc5[nH]4)n[nH]c3cn2)c1 CHEMBL4746668 EC50 3.0 nM
Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6ccncc6)cncc5[nH]4)c3c2)c1 CHEMBL4741393 EC50 3.0 nM
Nc1cncc(-c2cc3c(-c4cc5c(-c6ccncc6)cncc5[nH]4)n[nH]c3cn2)c1 CHEMBL4763601 EC50 3.0 nM
CCCCC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5cnccc5[nH]4)c3c2)c1 CHEMBL4751155 EC50 3.0 nM
CC(C)(C)CC(=O)Nc1cncc(-c2cc3c(-c4cc5cnccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4746032 EC50 3.0 nM
O=C(Nc1cncc(-c2cc3c(-c4cc5cnccc5[nH]4)n[nH]c3cn2)c1)C1CCCCC1 CHEMBL4756871 EC50 3.0 nM
O=C(Nc1cncc(-c2cc3c(-c4cc5cnccc5[nH]4)n[nH]c3cn2)c1)c1ccccc1 CHEMBL4758596 EC50 3.0 nM
CCNCc1cncc(-c2ccc3[nH]nc(-c4cc5cnccc5[nH]4)c3c2)c1 CHEMBL4753378 EC50 3.0 nM
FC1(F)CCN(Cc2cncc(-c3ccc4[nH]nc(-c5cc6cnccc6[nH]5)c4n3)c2)C1 CHEMBL4763390 EC50 3.0 nM
CN1CCN(c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(N)c6)cc45)cc23)CC1 CHEMBL4797723 EC50 3.0 nM
CCC(=O)Nc1cncc(-c2cc3c(-c4cc5c(N6CCN(C)CC6)nccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4795743 EC50 3.0 nM
CN1CCN(c2nccc3[nH]c(-c4n[nH]c5cnc(-c6cncc(NC(=O)C(C)(C)C)c6)cc45)cc23)CC1 CHEMBL4757534 EC50 3.0 nM
CN1CCN(c2nccc3[nH]c(-c4n[nH]c5cnc(-c6cncc(NC(=O)C7CCCCC7)c6)cc45)cc23)CC1 CHEMBL4749506 EC50 3.0 nM
CN(C)CCOc1cc(C(=O)Nc2cc3cc(-c4cnn(C)c4)ccc3cn2)ccn1 CHEMBL4783105 EC50 3.0 nM
Cc1cc(C(=O)Nc2cc3cc(-c4cnn(C)c4)ccc3cn2)cc(N2CCN(C)CC2)n1 CHEMBL4748781 EC50 3.0 nM
Cn1cc(-c2ccc3cnc(NC(=O)c4ccnc(OC5CNC5)c4)cc3c2)cn1 CHEMBL4777508 EC50 3.0 nM
Cn1cc(-c2ccc3cnc(NC(=O)c4cnc5ccccc5c4)cc3c2)cn1 CHEMBL4780800 EC50 3.0 nM
Cn1cc(-c2ccc3cnc(NC(=O)c4ccc5cnccc5c4)cc3c2)cn1 CHEMBL4758126 EC50 3.0 nM
CC(C)OC(=O)N1CCC(n2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)cn2)CC1 CHEMBL4746707 EC50 3.0 nM
Cn1ncc(-c2ccc3cnc(NC(=O)[C@H]4CC[C@H](CO)CC4)cc3c2)c1CN1CCCCC1 CHEMBL4752464 EC50 3.0 nM
Cn1ncc(-c2ccc3cnc(NC(=O)C4CCN(C(=O)c5ccccc5)CC4)cc3c2)c1CN1CCCCC1 CHEMBL4751301 EC50 3.0 nM
CC(C)N1CCC(n2cc(C(=O)Nc3cc4cc(-c5cn(C)nn5)ccc4cn3)cn2)CC1 CHEMBL4795948 EC50 3.0 nM
Cc1nnc(-c2ccc3cnc(NC(=O)c4ccnc(C5=CCN(C)CC5)c4)cc3c2)s1 CHEMBL4799760 EC50 3.0 nM
O=C(Nc1cc2cc(-c3cncc(CN4CCC(O)CC4)c3)ccc2cn1)c1ccc(F)cc1 CHEMBL4781707 EC50 3.0 nM
CN1CCC(n2cc(C(=O)Nc3cc4cc(-c5cncc6[nH]ccc56)ccc4cn3)cn2)CC1 CHEMBL4746469 EC50 3.0 nM
c1cc2cc(c1)-c1cncc3[nH]c(nc13)-c1n[nH]c3ccc(cc13)-c1cncc(c1)CNC2 CHEMBL4793171 EC50 3.0 nM
Cc1nc(-c2ccc3c(c2)OCO3)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5078833 IC50 3.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CCc1ccco1 CHEMBL5073976 IC50 3.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CC(F)F CHEMBL5077927 IC50 3.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CCOc1cccc(Cl)n1 CHEMBL5093661 IC50 3.0 nM
O=C1NC(N[C@@H]2CCCCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5414514 IC50 3.0 nM
O=C1NC(N[C@@H]2CCCC[C@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5401675 IC50 3.0 nM
O=C1NC(N[C@@H]2CCCC[C@@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5437778 IC50 3.0 nM
CC(C)C[C@H](CO)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5412105 IC50 3.0 nM
COC(=O)[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)C(C)O CHEMBL5401116 IC50 3.0 nM
CC(C)C[C@H](CF)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5426735 IC50 3.0 nM
CN(C)C12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5412565 IC50 3.0 nM
O=C1NC(NC2CCCSC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5405233 IC50 3.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 3.13 nM
CNCC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1996980 pKi 3.162 nM
NC(COc1cncc(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1981133 pKi 3.162 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 3.162 nM
O=C(Nc1cncc(-c2cc(-c3cccnc3)cs2)c1)C1CC1 CHEMBL4283503 IC50 3.2 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 3.2 nM
CCOC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1NC1CCN(C)CC1 CHEMBL4638152 MEC 3.3 nM
CCOC(=O)c1cnc2ccc(-c3ccnc(N)c3)nc2c1N[C@H]1CC[C@H](CN2CCOCC2)CC1 CHEMBL4638868 MEC 3.3 nM
c1cc(OCCN2CCCCC2)cc(-c2n[nH]c3ccc(-c4nnc[nH]4)cc23)c1 CHEMBL1614713 Kd 3.312 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 CHEMBL3301610 Kd 3.349 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(C#N)cc4)c3c2s1 CHEMBL2386766 IC50 3.89 nM
NC(COc1cncc(-c2cc3ccncc3s2)c1)Cc1c[nH]c2ccccc12 CHEMBL1966524 pKi 3.981 nM
NC(COc1cncc(-c2ccc3c(c2)CC(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL1967302 pKi 3.981 nM
Clc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 CHEMBL1969588 pKi 3.981 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4cnc5ccccc5c4)c3)cc21 CHEMBL226403 pKi 3.981 nM
Clc1cc(Cl)cc(CNc2nccc(-c3ccc4c(c3)OCO4)n2)c1 CHEMBL2392364 IC50 4.0 nM
C[C@]12O[C@H]([C@H](O)[C@H](O)[C@H]1O)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4=O CHEMBL4285678 IC50 4.0 nM
COc1ccc2c(c1)CC(n1c(C)nc3ccc(-c4cc(N)nc(N)c4)nc31)C2 CHEMBL4284240 IC50 4.0 nM
CCCCNC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN2CCOCC2)CC1 CHEMBL4634663 EC50 4.0 nM
CC(C)Oc1cncc(C(=O)Nc2c[nH]nc2C(=O)Nc2ccc(OC3CCN(C)CC3)nc2)c1 CHEMBL4790819 EC50 4.0 nM
O=C(Nc1c[nH]nc1-c1nc2c(-c3cccc(F)c3)cccc2[nH]1)c1cccnc1 CHEMBL4788972 EC50 4.0 nM
O=C(Nc1ccc(CN2CCCC2)cc1)c1n[nH]cc1/C=C/c1cccnc1 CHEMBL4756587 EC50 4.0 nM
O=C(Nc1ccc(OCCN2CCCC2)cc1)c1n[nH]cc1/C=C/c1cccnc1 CHEMBL4797418 EC50 4.0 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@H](N)Cc4ccccc4)n3)cc12 CHEMBL4780416 EC50 4.0 nM
O=C(N[C@H]1C[C@@H]1c1ccccc1)c1n[nH]c2ccc(-c3cccnc3)cc12 CHEMBL4776900 EC50 4.0 nM
CN1CCC(Oc2ccc(NC(=O)c3n[nH]c4ccc(-c5ccc(N)nc5)cc34)cc2)CC1 CHEMBL4788156 EC50 4.0 nM
O=C(Nc1ccnc(C(F)(F)F)c1)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4744530 EC50 4.0 nM
O=C(Nc1ccc(OC(CO)CO)nc1)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4752327 EC50 4.0 nM
CC(C)Oc1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CC6CC(C5)O6)c4)cc23)cn1 CHEMBL4743194 EC50 4.0 nM
O=C(Nc1ccc(CN2CCCC2)cc1)c1n[nH]c2ccc(-c3cncnc3)cc12 CHEMBL4755716 EC50 4.0 nM
O=C(Nc1ccc(CN2CCCC2)cc1)c1n[nH]c2ccc(-c3cnccn3)cc12 CHEMBL4743500 EC50 4.0 nM
O=C(Nc1ccc(CN2CCCC2)cc1)c1n[nH]c2ccc(-c3cnn(C4CC4)c3)cc12 CHEMBL4744357 EC50 4.0 nM
Cc1ncc(NC(=O)c2n[nH]c3ccc(-c4cnc(C)n4C)cc23)s1 CHEMBL4756183 EC50 4.0 nM
O=C(Nc1cccnc1)c1n[nH]c2cnc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4793803 EC50 4.0 nM
CN(C)C(=O)Nc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccc(F)c6)cncc5[nH]4)c3c2)c1 CHEMBL4755351 EC50 4.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(N6CCCCC6)cncc5[nH]4)c3c2)c1)C1CCC1 CHEMBL4752631 EC50 4.0 nM
CN1CCN(c2nccc3[nH]c(-c4n[nH]c5cc(F)c(-c6cnn(C)c6)cc45)nc23)CC1 CHEMBL4789036 EC50 4.0 nM
Cc1ccc(-c2nccc3[nH]c(-c4n[nH]c5cnc(-c6cncc(N)c6)cc45)nc23)s1 CHEMBL4778624 EC50 4.0 nM
CC(C)(C)CC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6cccnc6)cncc5[nH]4)c3c2)c1 CHEMBL4744328 EC50 4.0 nM
Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6ccncc6)nccc5[nH]4)c3c2)c1 CHEMBL4757102 EC50 4.0 nM
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccncc6)cncc5[nH]4)c3c2)c1 CHEMBL4760110 EC50 4.0 nM
O=C(Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6ccncc6)cncc5[nH]4)c3c2)c1)C1CCC1 CHEMBL4750354 EC50 4.0 nM
O=C(Nc1cncc(-c2cc3c(-c4cc5cnccc5[nH]4)n[nH]c3cn2)c1)C1CC1 CHEMBL4757454 EC50 4.0 nM
c1cc2[nH]c(-c3n[nH]c4ccc(-c5cncc(CN6CCCCC6)c5)cc34)cc2cn1 CHEMBL4754457 EC50 4.0 nM
c1cnc2[nH]c(-c3n[nH]c4ccc(-c5cncc(CN6CCCCC6)c5)cc34)cc2c1 CHEMBL4777829 EC50 4.0 nM
c1cc2cc(-c3n[nH]c4ccc(-c5cncc(OCCN6CCCC6)c5)cc34)[nH]c2cn1 CHEMBL4749742 EC50 4.0 nM
CN1CCN(c2nccc3[nH]c(-c4n[nH]c5cnc(-c6cncc(NC(=O)c7ccccc7)c6)cc45)cc23)CC1 CHEMBL4777935 EC50 4.0 nM
CN1CCN(c2cc(C(=O)Nc3cc4c(Cl)c(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 CHEMBL4758035 EC50 4.0 nM
Cn1ncc(-c2ccc3cnc(NC(=O)c4ccc(OC(F)F)cc4)cc3c2)c1CO CHEMBL4797187 EC50 4.0 nM
Cc1nnc(C(=O)Nc2cc3cc(-c4cncn4C)ccc3cn2)s1 CHEMBL4787749 EC50 4.0 nM
Cc1ncc(-c2ccc3cnc(NC(=O)c4ccc(OC(C)C)cc4)cc3c2)n1C CHEMBL4791186 EC50 4.0 nM
CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnc(N)s5)ccc4cn3)ccn2)CC1 CHEMBL4747892 EC50 4.0 nM
O=C(Nc1cc2cc(-c3cncc(NC4CCNCC4)n3)ncc2cn1)C1CCOCC1 CHEMBL4794913 EC50 4.0 nM
CN1CCCn2cc(nn2)-c2nccc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(c2)C1 CHEMBL4791855 EC50 4.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CCC1CCCCC1 CHEMBL5072926 IC50 4.0 nM
O=C1NC(NC2CC23CCCCC3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5434921 IC50 4.0 nM
CC(C)C[C@H](COC1CC1)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5396386 IC50 4.0 nM
CC(C)C[C@@H](CF)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5438412 IC50 4.0 nM
COC[C@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5439392 IC50 4.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)c(O)c4)c3c2s1 CHEMBL3905538 IC50 4.25 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc5nc[nH]c5c4)c3c2s1 CHEMBL3983413 IC50 4.44 nM
COc1cc2[nH]c(=O)c(C(=O)Nc3cc(C(=O)NC(CCN)c4ccsc4)ccc3Cl)cc2cn1 CHEMBL4282315 IC50 4.6 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(O)c([N+](=O)[O-])c4)c3c2s1 CHEMBL2386749 IC50 4.91 nM
NCCC(NC(=O)c1ccc(Cl)c(NC(=O)c2cc3cnc(N4CC5CCC(C4)O5)nc3[nH]c2=O)c1)c1ccccc1 CHEMBL3094437 IC50 5.0 nM
COCCc1cc2cc(C(=O)Nc3cc(C(=O)N[C@H](CCN)c4ccccc4)ccc3Cl)c(=O)[nH]c2cc1OC CHEMBL4288045 IC50 5.0 nM
CCCCCNC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL4633261 EC50 5.0 nM
N#Cc1cccc(Nc2nccc(-c3cnn4ncccc34)n2)c1 CHEMBL495696 IC50 5.0 nM
COc1ccc(NC(=O)c2n[nH]cc2/C=C/c2cncc(CN3CCCCC3)c2)cn1 CHEMBL4785138 EC50 5.0 nM
CC(C)OCCCNC(=O)c1n[nH]c2ccc(-c3cccnc3)cc12 CHEMBL4744152 EC50 5.0 nM
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5cncc(-c6cccc(F)c6)c5[nH]4)c3c2)c1 CHEMBL4297639 EC50 5.0 nM
O=C(CC1CCNCC1)Nc1cncc(-c2cc3c(-c4nc5c(-c6cccc(F)c6)ccnc5[nH]4)n[nH]c3cn2)c1 CHEMBL4782145 EC50 5.0 nM
CN(C)Cc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccc(F)c6)cncc5[nH]4)c3c2)c1 CHEMBL4740064 EC50 5.0 nM
CN(C)CCOc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccc(F)c6)nccc5[nH]4)c3c2)c1 CHEMBL4755870 EC50 5.0 nM
Fc1cccc(-c2cncc3[nH]c(-c4n[nH]c5cnc(-c6cncc(OC7CCNCC7)c6)cc45)nc23)c1 CHEMBL4762436 EC50 5.0 nM
Cc1ncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccc(F)c6)nccc5[nH]4)c3c2)n1C CHEMBL4791974 EC50 5.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccccc6F)ccnc5[nH]4)c3c2)c1 CHEMBL4758175 EC50 5.0 nM
CC(C)(C)C(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccnc6)cncc5[nH]4)c3c2)c1 CHEMBL4755029 EC50 5.0 nM
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(N6CCN(C)CC6)cccc5[nH]4)c3c2)c1 CHEMBL4780561 EC50 5.0 nM
CN(C)CCNc1cc(F)cc(-c2cncc3[nH]c(-c4n[nH]c5ncc(-c6cccnc6)cc45)nc23)c1 CHEMBL4740704 EC50 5.0 nM
CC(C)Nc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cc(F)cc(NCCN(C)C)c6)nccc5[nH]4)c3c2)c1 CHEMBL4749014 EC50 5.0 nM
Nc1cncc(-c2cc3c(-c4cc5c(-c6ccccc6F)nccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4780582 EC50 5.0 nM
CC(C)CC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6cccnc6)ccnc5[nH]4)c3c2)c1 CHEMBL4783658 EC50 5.0 nM
CC(C)(C)C(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6ccncc6)cncc5[nH]4)c3c2)c1 CHEMBL4763649 EC50 5.0 nM
c1cncc(-c2cc3c(-c4cc5cccnc5[nH]4)n[nH]c3cn2)c1 CHEMBL4753920 EC50 5.0 nM
c1cnc2cc(-c3n[nH]c4ccc(-c5cncc(CN6CCCCC6)c5)cc34)[nH]c2c1 CHEMBL4764806 EC50 5.0 nM
CCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(N6CCCCC6)nccc5[nH]4)c3c2)c1 CHEMBL4776104 EC50 5.0 nM
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(N6CCN(C)CC6)ccnc5[nH]4)c3n2)c1 CHEMBL4795751 EC50 5.0 nM
CN1CCC(n2cc(C(=O)Nc3cc4cc(-c5cnc6cc[nH]c6c5)ccc4cn3)cn2)CC1 CHEMBL4745584 EC50 5.0 nM
CC(C)OC(=O)N1CCC(n2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ncc4cn3)cn2)CC1 CHEMBL4790835 EC50 5.0 nM
O=C1COc2cccc(c2)-c2cncc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(c2)N1 CHEMBL4800405 EC50 5.0 nM
Oc1ccc(-c2cnc3[nH]nc(-c4ccc(O)cc4)c3c2)cc1 CHEMBL4856089 IC50 5.0 nM
Cc1nc(NCc2ncccc2F)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5088687 IC50 5.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C[C@@H](C)Oc1cccc(Br)n1 CHEMBL5084166 IC50 5.0 nM
O=C1NC(NC2CCCCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430192 IC50 5.0 nM
O=C1NC(NC2CCCCC2(F)F)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5396991 IC50 5.0 nM
CC(=O)OC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5412101 IC50 5.0 nM
O=C1NC(N[C@H]2c3ccccc3C[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429404 IC50 5.0 nM
O=C1NC(N[C@H](CO)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429783 IC50 5.0 nM
NCC(NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5438728 IC50 5.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL5428750 IC50 5.0 nM
OC1CCCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1976936 pKi 5.012 nM
COc1cc(C=C(C#N)c2nc3cc(C)ccc3[nH]2)c(Br)cc1O CHEMBL2000345 pKi 5.012 nM
Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL2007574 pKi 5.012 nM
COC(=O)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1 CHEMBL2386760 IC50 5.1 nM
COc1ccc2c(c1)[nH]c1c(C)nccc12 CHEMBL269538 Kd 5.474 nM
CCNc1cc(Nc2ccc(C(=O)N3CCC(N4CCOCC4)CC3)cc2OC)nc2[nH]cc(C(F)(F)F)c12 CHEMBL5273528 Kd 5.836 nM
NCC(Nc1nccc(-c2n[nH]c3nc(NCCN4CCOCC4)ncc23)n1)c1ccccc1 CHEMBL4284572 IC50 5.9 nM
COc1ccc2c3ccnc(Cl)c3n(CC#N)c2c1 CHEMBL4283240 Kd 5.969 nM
CN1CCN(CCCNc2ncc3cc(C(=O)Nc4cc(C(=O)NC(CCN)c5ccccc5)ccc4Cl)c(=O)[nH]c3n2)CC1 CHEMBL3094434 IC50 6.0 nM
COc1cc2[nH]c(=O)c(C(=O)Nc3cc(C(=O)NCc4cccc(Cl)c4)ccc3C)cc2cc1CCCN1CCOCC1 CHEMBL4286467 IC50 6.0 nM
CNC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL4644073 EC50 6.0 nM
CCNC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL4632891 EC50 6.0 nM
CCCNC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL4636396 EC50 6.0 nM
CC(C)CNC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL4646187 EC50 6.0 nM
Cc1n[nH]c2cc(F)c(-c3cncc(O[C@H]4CCNC[C@@H]4F)n3)cc12 CHEMBL4785637 EC50 6.0 nM
O=C(Nc1cccnc1)c1n[nH]c2ncc(-c3cccnc3)cc12 CHEMBL4753797 EC50 6.0 nM
O=C(Nc1cnccc1NC(=O)C1CC1)c1n[nH]c2ccc(-c3cccnc3)cc12 CHEMBL4778412 EC50 6.0 nM
NC(=O)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4792282 EC50 6.0 nM
CC(C)NC(=O)c1n[nH]c2ccc(-c3cncc(CN4CCC(F)(F)CC4)c3)cc12 CHEMBL4785348 EC50 6.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccccc6F)nccc5[nH]4)c3c2)c1 CHEMBL4761232 EC50 6.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccnc6)cncc5[nH]4)c3c2)c1)c1ccccc1 CHEMBL4786564 EC50 6.0 nM
FC1(F)CCN(Cc2cncc(-c3cc4c(-c5nc6c(N7CCCCC7)cncc6[nH]5)n[nH]c4cn3)c2)C1 CHEMBL4761624 EC50 6.0 nM
Cc1ccncc1-c1cc2c(-c3nc4c(-c5cc(F)cc(CNS(C)(=O)=O)c5)cncc4[nH]3)n[nH]c2cn1 CHEMBL4791409 EC50 6.0 nM
CC(C)C(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccnc6)cncc5[nH]4)c3c2)c1 CHEMBL4758034 EC50 6.0 nM
CCCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccncc6)cncc5[nH]4)c3c2)c1 CHEMBL4761515 EC50 6.0 nM
O=C(Nc1cncc(-c2cc3c(-c4cc5cccnc5[nH]4)n[nH]c3cn2)c1)C1CC1 CHEMBL4740976 EC50 6.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4cc5cccnc5[nH]4)c3c2)c1)C1CCCC1 CHEMBL4776789 EC50 6.0 nM
Nc1cncc(-c2cc3c(-c4cc5c(N6CCCCC6)cncc5[nH]4)n[nH]c3cn2)c1 CHEMBL4763741 EC50 6.0 nM
O=C(CC1CCNCC1)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(N6CCCCC6)nccc5[nH]4)c3n2)c1 CHEMBL4795946 EC50 6.0 nM
CCNCc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6cc(F)cc(CNS(C)(=O)=O)c6)cncc5[nH]4)c3c2)c1 CHEMBL4788404 EC50 6.0 nM
CC#CC(=O)Nc1cc2cc(-c3cnn(C)c3)ccc2cn1 CHEMBL4789335 EC50 6.0 nM
O=C(Nc1cc2cc(-c3cnn4c3CCNC4)ccc2cn1)c1ccc(OC(F)F)cc1 CHEMBL4794929 EC50 6.0 nM
Cc1ncc(-c2ccc3cnc(NC(=O)C4(F)CC4)cc3c2)n1C CHEMBL4752888 EC50 6.0 nM
Cc1nc(OCc2ccsc2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5091510 IC50 6.0 nM
Cc1nc(NCc2ccccc2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5092157 IC50 6.0 nM
COCCCn1c(C)nc2ccc(-c3cc(N)nc(N)c3)nc21 CHEMBL5089294 IC50 6.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CCCC(F)(F)F CHEMBL5080497 IC50 6.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CCOc1ccccn1 CHEMBL5077422 IC50 6.0 nM
CC(C)Oc1ccc(F)c(-c2cnc(N)c(C(=O)Nc3cnccc3N3CCCC(C(=O)O)C3)n2)c1 CHEMBL5186778 IC50 6.0 nM
Nc1ncc(-c2ccccc2)nc1C(=O)Nc1cnccc1N1CCC(C(=O)O)CC1 CHEMBL4638292 IC50 6.0 nM
O=C1NC(NC2C3CC4CC(C3)CC2C4)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5417207 IC50 6.0 nM
O=C1NC(NCc2ccccc2C(F)(F)F)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430415 IC50 6.0 nM
CCOC(=N)c1nc2ccc3ncnc(Nc4ccc5c(c4)OCO5)c3c2s1 CHEMBL2386754 IC50 6.02 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4)c3c2s1 CHEMBL2386765 IC50 6.06 nM
CCN1CCN(C(=O)Nc2cc(-c3cn(C4CCOCC4)c4cnccc34)ccn2)CC1 CHEMBL4636064 IC50 6.2 nM
COc1cc(C=C2SC(=S)NC2=O)ccc1O CHEMBL1973098 pKi 6.31 nM
c1ccc(CNc2nc3ccc(-c4ccncc4)cc3s2)cc1 CHEMBL1983534 pKi 6.31 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(F)n1 CHEMBL1987261 pKi 6.31 nM
Cn1cc(Nc2ncc(Br)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1994669 pKi 6.31 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 6.31 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 6.31 nM
CN(C)CCn1cc(-c2ccn3c(-c4ccc(C(N)=O)c(OCc5cccc(F)c5)c4)cnc3c2)cn1 CHEMBL4062453 IC50 6.5 nM
CC(=O)Nc1ccc(-c2cnc3[nH]cc(-c4ccc(O)cc4)c3c2)cc1 CHEMBL4078550 IC50 6.6 nM
c1cncc(CNc2nccc(-c3ccc4c(c3)OCO4)n2)c1 CHEMBL1877990 IC50 7.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C1CC1 CHEMBL4460561 IC50 7.0 nM
CCOC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN2CCOCC2)CC1 CHEMBL4649268 EC50 7.0 nM
Cc1cccc(Nc2nccc(-c3cnn4ncccc34)n2)c1 CHEMBL4646866 IC50 7.0 nM
COc1cncc(C(=O)Nc2c[nH]nc2C(=O)Nc2ccc(N3CCNCC3)nc2)c1 CHEMBL4788757 EC50 7.0 nM
O=C(Nc1ccc(-c2ccccc2)nc1)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4743940 EC50 7.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccccc6F)cncc5[nH]4)c3n2)c1 CHEMBL4786746 EC50 7.0 nM
c1cncc(-c2cncc3[nH]c(-c4n[nH]c5ncc(-c6cncnc6)cc45)cc23)c1 CHEMBL4742941 EC50 7.0 nM
c1cc2[nH]c(-c3n[nH]c4ncc(-c5cncc(CN6CCCCC6)c5)cc34)cc2cn1 CHEMBL4789272 EC50 7.0 nM
CN1CCN(c2ccnc3[nH]c(-c4n[nH]c5ccc(-c6cncc(N)c6)cc45)cc23)CC1 CHEMBL4744948 EC50 7.0 nM
CC(C)C(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(N6CCN(C)CC6)nccc5[nH]4)c3c2)c1 CHEMBL4797092 EC50 7.0 nM
CN1CCN(c2nccc3[nH]c(-c4n[nH]c5ncc(-c6cncc(NC(=O)C7CCCC7)c6)cc45)cc23)CC1 CHEMBL4782101 EC50 7.0 nM
CN1CCN(c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(CNCc7ccccc7)c6)cc45)cc23)CC1 CHEMBL4785840 EC50 7.0 nM
CN1CCN(c2cc(C(=O)Nc3cc4nc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 CHEMBL4743920 EC50 7.0 nM
Cn1cc(-c2ccc3cnc(NC(=O)c4ccc5nccnc5c4)cc3n2)cn1 CHEMBL4794127 EC50 7.0 nM
CN1CCC(n2cc(C(=O)Nc3ncc4ccc(-c5cncc6[nH]ccc56)cc4n3)cn2)CC1 CHEMBL4748839 EC50 7.0 nM
CNc1nc(NCc2ncccn2)c2c(-c3ccc4ncccc4c3)c[nH]c2n1 CHEMBL4797564 EC50 7.0 nM
CN1CC2CCC(C1)N2C(=O)Nc1cc2cc(-c3cnn(C)c3)ccc2cn1 CHEMBL4740450 EC50 7.0 nM
Cc1nc(NCc2cccs2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5082044 IC50 7.0 nM
Cc1nc(NCc2ccsc2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5083159 IC50 7.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C(C)(C)C CHEMBL5094409 IC50 7.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C[C@@H](C)Oc1ccccn1 CHEMBL5092833 IC50 7.0 nM
CN1CCN(c2ccc(NC3=N/C(=C\C4=COc5ccccc5O4)C(=O)N3)cc2)CC1 CHEMBL5195216 IC50 7.0 nM
Cn1cnc2ccc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)cc21 CHEMBL5420645 IC50 7.0 nM
COC(CNC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)C1CCCCC1 CHEMBL5423402 IC50 7.0 nM
COC(=O)[C@H](C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5423907 IC50 7.0 nM
COC(=O)[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)C(C)C CHEMBL5416274 IC50 7.0 nM
CN1CCN(c2ccc(NC3=N/C(=C\c4ccc5c(c4)OCCO5)C(=O)N3)cc2)CC1 CHEMBL5414801 IC50 7.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL1802358 Kd 7.236 nM
O=C1N=C(Nc2ccccc2)N=C1Cc1ccc2c(c1)OCO2 CHEMBL1738733 IC50 7.6 nM
N=C1NC(=O)/C(=C/c2ccc3c(c2)CCO3)S1 CHEMBL4283751 IC50 7.9 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 7.943 nM
NC(COc1cncc(-c2ccc3[nH]c(=O)oc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1987679 pKi 7.943 nM
COc1cc(C=C(C#N)c2nc3ccccc3[nH]2)c(Br)cc1O CHEMBL1994241 pKi 7.943 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 7.943 nM
COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CN)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094454 IC50 8.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc5c(c4)OCCO5)c3c2s1 CHEMBL3912295 IC50 8.0 nM
c1cc(-c2cn(CCC3CC3)c3cnccc23)ccn1 CHEMBL4105629 IC50 8.0 nM
CC(C)n1cc(-c2ccncc2)c2ccncc21 CHEMBL4064316 IC50 8.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C[C@@H](C)Oc1ccccc1 CHEMBL4575900 IC50 8.0 nM
COc1cncc(C(=O)Nc2c[nH]nc2C(=O)Nc2ccc3c(c2)CCNC3)c1 CHEMBL4749673 EC50 8.0 nM
COc1cncc(C(=O)Nc2c[nH]nc2C(=O)Nc2ccc3c(c2)CCN(C)C3)c1 CHEMBL4743693 EC50 8.0 nM
CCN(C)Cc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccc(F)c6)cncc5[nH]4)c3c2)c1 CHEMBL4765065 EC50 8.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccccc6F)nccc5[nH]4)c3n2)c1 CHEMBL4763852 EC50 8.0 nM
CC(C)(C)C(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(N6CCCCC6)cncc5[nH]4)c3c2)c1 CHEMBL4784341 EC50 8.0 nM
Cc1cn(-c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)C7CCC7)c6)nc45)nc23)cn1 CHEMBL4754156 EC50 8.0 nM
CCCC(=O)Nc1cncc(-c2cc3c(-c4nc5c(-c6ccsc6)cncc5[nH]4)n[nH]c3cn2)c1 CHEMBL4786673 EC50 8.0 nM
Fc1ccc(-c2cncc3[nH]c(-c4n[nH]c5cnc(-c6cncc(CN7CCCC7)c6)cc45)nc23)s1 CHEMBL4778226 EC50 8.0 nM
CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cc(F)cc(NCCN(C)C)c6)ccnc5[nH]4)c3n2)c1 CHEMBL4798951 EC50 8.0 nM
Cc1ncc(-c2ccc3[nH]nc(-c4nc5c(-c6cc(F)cc(NCCN(C)C)c6)ccnc5[nH]4)c3n2)n1C CHEMBL4790085 EC50 8.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccncc6)ccnc5[nH]4)c3n2)c1 CHEMBL4744766 EC50 8.0 nM
CC(C)(C)C(=O)Nc1cncc(-c2cc3c(-c4cc5c(-c6ccncc6)cncc5[nH]4)n[nH]c3cn2)c1 CHEMBL4743111 EC50 8.0 nM
O=C(Cc1ccccc1)Nc1cncc(-c2ccc3[nH]nc(-c4cc5cnccc5[nH]4)c3c2)c1 CHEMBL4740858 EC50 8.0 nM
Cn1cc(-c2cnc3[nH]nc(-c4cc5cccnc5[nH]4)c3c2)cn1 CHEMBL4795309 EC50 8.0 nM
CN1CCN(c2cc(C(=O)Nc3ncc4ccc(-c5cnn(C)c5)cc4n3)ccn2)CC1 CHEMBL4778580 EC50 8.0 nM
CN1CCC2(CC1)CN(c1cc(C(=O)Nc3cc4cc(-c5cnn(C)c5CN5CCCCC5)cnc4cn3)ccn1)C2 CHEMBL4779822 EC50 8.0 nM
O=C(Nc1cc2cc(-c3cncs3)ccc2cn1)C1(F)CCCCC1 CHEMBL4792722 EC50 8.0 nM
COc1ccc(-c2n[nH]c3ncc(-c4ccc(NC(C)=O)cc4)cc23)cc1 CHEMBL4872136 IC50 8.0 nM
Cc1nc(NCc2c(F)cccc2F)c2c(-c3ccnc(N)n3)c[nH]c2n1 CHEMBL5073598 IC50 8.0 nM
CCCCc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CCCC CHEMBL5091644 IC50 8.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C[C@H](C)Oc1ccccc1 CHEMBL5071425 IC50 8.0 nM
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCCC1CCN(Cc2ccc(F)cc2)CC1 CHEMBL4747992 IC50 8.1 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(O)c(F)c4)c3c2s1 CHEMBL2386752 IC50 8.63 nM
COc1ccc2c(c1)[nH]c1c(Cl)nccc12 CHEMBL4159941 IC50 8.8 nM
NCCC(NC(=O)c1ccc(Cl)c(NC(=O)c2cc3cnc(N4CCC(N)CC4)nc3[nH]c2=O)c1)c1ccccc1 CHEMBL3094436 IC50 9.0 nM
COc1ncc2cc(C(=O)Nc3cc(C(=O)N[C@H](CCN)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094460 IC50 9.0 nM
COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CCN)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094455 IC50 9.0 nM
CCOC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](N)CC1 CHEMBL4638545 EC50 9.0 nM
O=C(Nc1c[nH]nc1C(=O)Nc1ccc(N2CCCC2)nc1)c1cncc(OC2CCNCC2)c1 CHEMBL4762971 EC50 9.0 nM
COc1cncc(C#Cc2c[nH]nc2C(=O)Nc2ccc(OC3CCN(C)CC3)nc2)c1 CHEMBL4747378 EC50 9.0 nM
Cc1n[nH]c2ccc(-c3cncc(NC4CCNCC4)n3)cc12 CHEMBL4755807 EC50 9.0 nM
CN1CCN(c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(N)c6)nc45)nc23)CC1 CHEMBL4757486 EC50 9.0 nM
Cc1cn(-c2nccc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)CC(C)C)c6)cc45)nc23)cn1 CHEMBL4740717 EC50 9.0 nM
CN(C)Cc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccs6)cncc5[nH]4)c3c2)c1 CHEMBL4760436 EC50 9.0 nM
CC(C)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cc(F)cc(NCCN(C)C)c6)cncc5[nH]4)c3n2)c1 CHEMBL4754511 EC50 9.0 nM
c1cncc(-c2cnc3[nH]nc(-c4cc5cccnc5[nH]4)c3c2)c1 CHEMBL4761786 EC50 9.0 nM
CC(C)n1cc(C(=O)Nc2cc3cc(-c4cncn4C(C)C)ccc3cn2)cn1 CHEMBL4754087 EC50 9.0 nM
O=C1CCc2cccc(c2)-c2cncc(c2)NC(=O)c2n[nH]c3ccc(cc23)-c2cncc(c2)CN1 CHEMBL4784103 EC50 9.0 nM
CO[C@H]1CCC[C@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CC1 CHEMBL5396280 IC50 9.0 nM
CC(C)(C)NC(=O)OC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5421442 IC50 9.0 nM
Oc1ccc(-c2cnc3[nH]cc(-c4ccc(F)cc4)c3c2)cc1O CHEMBL4292553 IC50 9.4 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4OC)c3c2s1 CHEMBL2386743 IC50 9.53 nM
NC(=O)c1cc2c(-c3ccc(C(=O)NCc4ccccc4O)s3)cccc2s1 CHEMBL5203374 Ki 9.9 nM