O=C1NC(NC23CC4CC(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5438158 IC50 0.0 nM
Fc1ccccc1-n1cc(-c2ccnc(NC3CCOCC3)n2)cn1 CHEMBL4797548 IC50 0.002 nM
CCNc1nccc(-c2cnn(-c3ccccc3F)c2)n1 CHEMBL4785938 IC50 0.003 nM
COc1ccccc1-n1cc(-c2ccnc(NCc3c(C)n[nH]c3C)n2)cn1 CHEMBL4794264 IC50 0.003 nM
Fc1ccccc1-n1cc(-c2ccnc(NCc3ccncc3)n2)cn1 CHEMBL4787263 IC50 0.004 nM
Cc1nc(NCc2c(F)cccc2F)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5093650 Kd 0.05 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CC(F)(F)F CHEMBL5070553 K 0.12 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(Br)cc4F)c3c2s1 CHEMBL2386744 IC50 0.24 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4Br)c3c2s1 CHEMBL2386770 IC50 0.24 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1 CHEMBL2386747 IC50 0.28 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4OC)c3c2s1 CHEMBL2386745 IC50 0.59 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4F)c3c2s1 CHEMBL3894571 IC50 0.59 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 0.631 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C1CC1 CHEMBL4460561 K 0.76 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.967 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 1.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1cc(-c2c[nH]c3cnccc23)ncn1 CHEMBL3421963 IC50 1.0 nM
Cc1nc(OCc2ccsc2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5091510 IC50 1.0 nM
Cc1nc(OCc2cncs2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5090676 IC50 1.0 nM
Cc1nc(NCc2ccccc2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5092157 IC50 1.0 nM
Cc1nc(NCc2cccs2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5082044 IC50 1.0 nM
Cc1nc(NCc2ccsc2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5083159 IC50 1.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5091238 IC50 1.0 nM
O=C1NC(NC23CC4CC(CC2C4)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5400230 IC50 1.0 nM
O=C1NC(NC23CC4CC(CC(O)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5405059 IC50 1.0 nM
O=C1NC(NC23CC4(F)CC(F)(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5422486 IC50 1.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4F)c3c2s1 CHEMBL2386748 IC50 1.07 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C(C)C CHEMBL4441878 IC50 1.1 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4Cl)c3c2s1 CHEMBL2386746 IC50 1.63 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4F)c3c2s1 CHEMBL3971170 IC50 1.63 nM
NC(COc1cncc(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1981133 pKi 1.995 nM
Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL2007574 pKi 1.995 nM
CN1CCN(c2ccc(Nc3cc(-c4c[nH]c5cnccc45)ncn3)cc2)CC1 CHEMBL3421962 IC50 2.0 nM
COc1ccc(-c2n[nH]c3ncc(-c4ccc(NC(N)=O)cc4)cc23)cc1 CHEMBL4872233 IC50 2.0 nM
CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 CHEMBL4784318 IC50 2.0 nM
COC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5417147 IC50 2.0 nM
CS(=O)(=O)NC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5409574 IC50 2.0 nM
O=C1NC(N[C@H]2c3ccccc3C[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429404 IC50 2.0 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 2.512 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(C)cc4)c3c2s1 CHEMBL2386764 IC50 2.83 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1nccc(-c2cn(C)c3cnccc23)n1 CHEMBL3421968 IC50 3.0 nM
c1cc2c(-c3ccnc4[nH]ccc34)c[nH]c2cn1 CHEMBL3421981 IC50 3.0 nM
Oc1ccc(-c2n[nH]c3ncc(-c4ccc(O)c(O)c4)cc23)cc1 CHEMBL4873449 IC50 3.0 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnc2ccc(Br)cn12 CHEMBL393525 IC50 3.4 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccccc4)c3c2s1 CHEMBL2386763 IC50 3.48 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 CHEMBL3301610 IC50 3.5 nM
COC(=N)c1nc2ccc3ncnc(Nc4cc(Br)c5c(c4)OCO5)c3c2s1 CHEMBL3915647 IC50 3.66 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 Kd 3.9 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 3.981 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1nccc(-c2c[nH]c3cnc(C)cc23)n1 CHEMBL3421969 IC50 4.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1nccc(-c2c[nH]c3cnccc23)n1 CHEMBL3421967 IC50 4.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2[nH]cnc2c1 CHEMBL5404416 IC50 4.0 nM
CC(=O)NC12CC3CC(C1)CC(NC1=N/C(=C\c4ccc5ncsc5c4)C(=O)N1)(C3)C2 CHEMBL5422654 IC50 4.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc5c(c4)OCO5)c3c2s1 CHEMBL2386753 IC50 4.2 nM
O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 CHEMBL1230165 IC50 4.6 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc5nc[nH]c5c4)c3c2s1 CHEMBL3983413 IC50 4.65 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4)c3c2s1 CHEMBL2386762 IC50 4.74 nM
Cn1cc(-c2ccc3cnc(NC(=O)C4CCN(S(C)(=O)=O)CC4)cc3c2)cn1 CHEMBL5285332 IC50 4.8 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1nccc(-c2c[nH]c3c(C)nccc23)n1 CHEMBL3421970 IC50 5.0 nM
CS(=O)(=O)Nc1ccc(-c2cnc3[nH]nc(-c4ccc(O)cc4)c3c2)cc1 CHEMBL4874485 IC50 5.0 nM
CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]c(F)c(c3c2)-c2cn(nc2C(F)(F)F)CCCC1=O CHEMBL5086263 IC50 5.0 nM
CC(C)Oc1ccc(F)c(-c2cnc(N)c(C(=O)Nc3cnccc3N3CCC[C@@H](C(=O)O)C3)n2)c1 CHEMBL4647659 IC50 5.0 nM
O=C1NC(NC2CCCCC(F)(F)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5396550 IC50 5.0 nM
CCOC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5409730 IC50 5.0 nM
O=C1NC(NC23CC4CC(CC(NC(=O)C5CC5)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5418722 IC50 5.0 nM
CN(C)C12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5412565 IC50 5.0 nM
O=C1NC(N[C@@H](CO)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5404544 IC50 5.0 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 5.012 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cc(F)ccc1F CHEMBL1995811 pKi 5.012 nM
O=C1N=C(Nc2c(Cl)cccc2Cl)S/C1=C\c1ccc2nccnc2c1 CHEMBL5081787 IC50 5.4 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(O)c([N+](=O)[O-])c4)c3c2s1 CHEMBL2386749 IC50 5.68 nM
Oc1ccc(-c2cnc3[nH]nc(-c4ccc(O)cc4)c3c2)cc1 CHEMBL4856089 IC50 6.0 nM
Cn1cc2cc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)ccc2n1 CHEMBL5408531 IC50 6.0 nM
CC(C)C[C@H](CO)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5412105 IC50 6.0 nM
CC(C)C[C@H](COC1CC1)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5396386 IC50 6.0 nM
CC(=O)OC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5412101 IC50 6.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5426285 IC50 6.0 nM
Clc1cc(Cl)cc(CNc2nccc(-c3ccc4c(c3)OCO4)n2)c1 CHEMBL2392364 IC50 7.0 nM
Cc1nccc(-c2cn(Cc3ccccc3)c3cnccc23)n1 CHEMBL3421980 IC50 7.0 nM
C(=C/c1nccc(-c2c[nH]c3cnccc23)n1)\c1ccccc1 CHEMBL3421978 IC50 7.0 nM
COc1ccc(-c2n[nH]c3ncc(-c4ccc(NC(C)=O)cc4)cc23)cc1 CHEMBL4872136 IC50 7.0 nM
Cc1nc(NCc2ncccc2F)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5088687 IC50 7.0 nM
C[C@@H]1[C@H]2C[C@@H](C[C@H]1NC1=N/C(=C\c3ccc4ncsc4c3)C(=O)N1)C2(C)C CHEMBL5416470 IC50 7.0 nM
O=C1Nc2cc(CS(=O)(=O)c3c(Cl)cccc3Cl)ccc2S/C1=C\c1ccc(O)c([N+](=O)[O-])c1 CHEMBL5437737 IC50 7.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(C#N)cc4)c3c2s1 CHEMBL2386766 IC50 7.69 nM
COC(=O)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1 CHEMBL2386760 IC50 7.7 nM
O=C(O)c1nc2ccccc2c2[nH]c3c(I)cccc3c12 CHEMBL3589662 IC50 7.7 nM
CCOC(=N)c1nc2ccc3ncnc(Nc4ccc5c(c4)OCO5)c3c2s1 CHEMBL2386754 IC50 7.72 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCCCC2)n1 CHEMBL2006439 pKi 7.943 nM
NCCC(NC(=O)c1ccc(Cl)c(NC(=O)c2cc3cnc(N4CC5CCC(C4)O5)nc3[nH]c2=O)c1)c1ccccc1 CHEMBL3094437 IC50 8.0 nM
CCOc1ccccc1CNc1nc(C)nc2[nH]cc(-c3ccnc(N)c3)c12 CHEMBL4294976 IC50 8.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5420724 IC50 8.0 nM
CC1(C)C2CCC1(C)[C@H](NC1=N/C(=C\c3ccc4ncsc4c3)C(=O)N1)C2 CHEMBL5412900 IC50 8.0 nM
COC[C@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5439392 IC50 8.0 nM
COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CN)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094454 IC50 9.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1nccc(-c2cn(C)c3c(C)nccc23)n1 CHEMBL3421971 IC50 9.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1nccc(-c2c[nH]c3cnccc23)n1 CHEMBL3421966 IC50 9.0 nM
Cc1nc(NCc2ccoc2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5092828 IC50 9.0 nM
O=C1NC(NC2CCCCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430192 IC50 9.0 nM
O=C1NC(N[C@@H]2CCCCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5414514 IC50 9.0 nM
CC(C)C[C@H](CF)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5426735 IC50 9.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1C CHEMBL5085086 IC50 9.6 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4)c3c2s1 CHEMBL2386765 IC50 9.64 nM
CC(C)CN1CCC(C(=O)Nc2cc3cc(-c4cnn(C)c4)ccc3cn2)CC1 CHEMBL5289681 IC50 9.7 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL225519 pKi 10.0 nM
Clc1ccnc2ccc(-c3c[nH]c4ncccc34)cc12 CHEMBL4795459 IC50 10.0 nM
CN1CCC(Nc2ccnc3ccc(-c4c[nH]c5ncccc45)cc23)CC1 CHEMBL4794147 IC50 10.0 nM
Cc1cc(-c2c[nH]c3ncccc23)cc2c(-c3cccnc3)ccnc12 CHEMBL4785328 IC50 10.0 nM
C=CCN(C)C(=O)c1cnc2[nH]cc(-c3ccc4nccc(Cl)c4c3)c2c1 CHEMBL4798594 IC50 10.0 nM
C=CCCCc1ccnc2ccc(-c3c[nH]c4ncc(CN(C)CC=C)cc34)cc12 CHEMBL4780313 IC50 10.0 nM
C=CCN(C)C(=O)c1cnc2[nH]cc(-c3cc(Cl)c4ncccc4c3)c2c1 CHEMBL4788999 IC50 10.0 nM
O=C(NCc1ccccc1)c1cnc2[nH]cc(-c3cc(Cl)c4ncccc4c3)c2c1 CHEMBL4796652 IC50 10.0 nM
O=C(NCc1ccccc1)c1cnc2[nH]cc(-c3cc(F)c4nccc(-c5cccnc5)c4c3)c2c1 CHEMBL4797371 IC50 10.0 nM
C=CCN(C)C(=O)c1cnc2[nH]cc(-c3cc(F)c4nccc(-c5cccnc5)c4c3)c2c1 CHEMBL4780889 IC50 10.0 nM
C=CCN(C)Cc1cnc2[nH]cc(-c3cc(F)c4nccc(-c5cccnc5)c4c3)c2c1 CHEMBL4782648 IC50 10.0 nM
CNC(=O)c1cnc2[nH]cc(-c3ccc4ncc([N+](=O)[O-])c(N5CCC[C@H](N)C5)c4c3)c2c1 CHEMBL4780461 IC50 10.0 nM
CNC(=O)c1cnc2[nH]cc(-c3ccc4ncc(NCc5cccc(Cl)c5)c(N5CCC[C@H](N)C5)c4c3)c2c1 CHEMBL4790751 IC50 10.0 nM
CNC(=O)c1cnc2[nH]cc(-c3ccc4ncc(NCc5cccc(Cl)c5)c(N5CCOCC5)c4c3)c2c1 CHEMBL4782343 IC50 10.0 nM
CNC(=O)c1cnc2[nH]cc(-c3ccc4ncc(NCC5CCOCC5)c(N5CCOCC5)c4c3)c2c1 CHEMBL4785163 IC50 10.0 nM
N[C@H]1CC[C@H](Nc2c([N+](=O)[O-])cnc3ccc(-c4c[nH]c5ncc(C(=O)NCc6cccnc6)cc45)cc23)CC1 CHEMBL4799177 IC50 10.0 nM
N[C@H]1CC[C@H](Nc2c(NCC3CCOCC3)cnc3ccc(-c4c[nH]c5ncc(C(=O)NCc6cccnc6)cc45)cc23)CC1 CHEMBL4780385 IC50 10.0 nM
CN1CCC(Nc2c(C#N)cnc3ccc(-c4c[nH]c5ncccc45)cc23)CC1 CHEMBL4796415 IC50 10.0 nM
CN1CCC(N(C)c2c([N+](=O)[O-])cnc3ccc(-c4c[nH]c5ncccc45)cc23)CC1 CHEMBL4784584 IC50 10.0 nM
NC(=O)Nc1ccc(-c2cnc3[nH]nc(-c4ccc(O)cc4)c3c2)cc1 CHEMBL4872950 IC50 10.0 nM
Cc1nc(NCc2c(F)cccc2F)c2c(-c3ccnc(N)n3)c[nH]c2n1 CHEMBL5073598 IC50 10.0 nM
Cc1nc(-c2ccc3c(c2)OCO3)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5078833 IC50 10.0 nM
O=C1NC(N[C@H]2C3CC4CC2C[C@](O)(C4)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5428651 IC50 10.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(O)c(F)c4)c3c2s1 CHEMBL2386752 IC50 11.0 nM
COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CCN)c4cccc(Cl)c4)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094462 IC50 11.0 nM
Cn1cnc2ccc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)cc21 CHEMBL5420645 IC50 11.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4OC)c3c2s1 CHEMBL2386743 IC50 11.13 nM
c1cncc(CNc2nccc(-c3ccc4c(c3)OCO4)n2)c1 CHEMBL1877990 IC50 12.0 nM
Cn1cc(-c2ccnc(-c3ccc(S(C)(=O)=O)cc3)n2)c2ccncc21 CHEMBL3421976 IC50 12.0 nM
O=C1NC(NC(CF)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5404644 IC50 12.0 nM
Cc1n[nH]c2ccc(-c3cccnc3)cc12 CHEMBL1967252 pKi 12.59 nM
COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CCN)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094455 IC50 13.0 nM
CC(=O)Nc1ccc(-c2cnc3[nH]nc(-c4ccc(O)cc4)c3c2)cc1 CHEMBL4874247 IC50 13.0 nM
Cc1nc(OCc2ccccc2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5081888 IC50 13.0 nM
O=C1NC(NC2CC23CCCCC3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5434921 IC50 13.0 nM
COc1cc2[nH]c(=O)c(C(=O)Nc3cc(C(=O)NC(CCN)c4ccsc4)ccc3Cl)cc2cn1 CHEMBL4282315 IC50 13.8 nM
O=C1NC(NC2CCCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5283849 IC50 13.9 nM
Cc1nccc2c(-c3ccnc(-c4ccc(S(C)(=O)=O)cc4)n3)c[nH]c12 CHEMBL3421977 IC50 14.0 nM
CN1CCN(c2ccc(NC3=N/C(=C\c4ccc5c(c4)OCO5)C(=O)N3)cc2)CC1 CHEMBL5179655 IC50 14.0 nM
O=C1NC(NC2CCCCC2(F)F)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5396991 IC50 14.0 nM
CC(C)(C)NC(=O)OC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5421442 IC50 14.0 nM
O=C1NC(NCc2ccccc2C(F)(F)F)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430415 IC50 14.0 nM
Oc1ccc(-c2cnc3[nH]cc(-c4ccc(O)cc4)c3c2)cc1 CHEMBL3102950 IC50 15.0 nM
COc1ncc(-c2n[nH]c3ncc(-c4ccc(O)c(O)c4)cc23)cn1 CHEMBL4850675 IC50 15.0 nM
O=C1NC(NC2CCCCCC2)=N/C1=C\c1ccc2ncoc2c1 CHEMBL5430824 IC50 15.0 nM
O=C1NC(NC2CCCC(F)(F)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5411888 IC50 15.0 nM
NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1973720 pKi 15.85 nM
CCOc1ccc(C=C2SC(=N)NC2=O)c(O)c1 CHEMBL1971289 pKi 15.85 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 15.85 nM
CCCC(=O)Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1998470 pKi 15.85 nM
COc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1OC CHEMBL1991078 pKi 15.85 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCNCC4)cc3)n2)s1 CHEMBL1999484 pKi 15.85 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1cc(-c2c[nH]c3cnccc23)ncn1 CHEMBL3421964 IC50 16.0 nM
CN1CCN(c2ccc(NC3=N/C(=C\c4ccc5ncsc5c4)C(=O)N3)cc2)CC1 CHEMBL5397343 IC50 16.0 nM
COc1ncc2cc(C(=O)Nc3cc(C(=O)N[C@H](CCN)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094460 IC50 17.0 nM
Cc1nccc(-c2c[nH]c3cnccc23)n1 CHEMBL3421979 IC50 17.0 nM
NC(=O)Nc1ccc(-c2cnc3[nH]cc(-c4ccc(O)cc4)c3c2)cc1 CHEMBL4067661 IC50 17.0 nM
COC1=CC2C(=O)NC3=Cc4ccc(OC)cc4C(=C1OC)C32 CHEMBL5279705 IC50 17.4 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc5c(c4)OCCO5)c3c2s1 CHEMBL3912295 IC50 17.6 nM
FC(F)(F)c1cccc(Nc2nccc(-c3ccc4c(c3)OCO4)n2)c1 CHEMBL1868723 IC50 18.0 nM
Brc1cc(Br)cc(CNc2nccc(-c3ccc4c(c3)OCO4)n2)c1 CHEMBL2392365 IC50 18.0 nM
Cc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CCN)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094438 IC50 18.0 nM
Cc1nc(OCc2cc(C)on2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5090159 IC50 18.0 nM
CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]cc(c3n2)-c2cn(nc2C(F)(F)F)CCCC1=O CHEMBL5089965 IC50 18.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2[nH]ncc2c1 CHEMBL5405572 IC50 18.0 nM
NC[C@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5406081 IC50 18.0 nM
NCC(Nc1nccc(-c2n[nH]c3nc(NCCN4CCOCC4)ncc23)n1)c1ccccc1 CHEMBL4284572 IC50 18.3 nM
COC(=N)c1nc2ccc3ncnc(Nc4cccc(Cl)c4)c3c2s1 CHEMBL2386751 IC50 18.78 nM
CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]cc(c3c2)-c2cn(nc2C(F)(F)F)CCCC1=O CHEMBL5093741 IC50 19.0 nM
CN1Cc2nn(C)cc2-c2cnc3[nH]cc(c3c2)-c2cnn(c2)CCCC1=O CHEMBL5075335 IC50 19.0 nM
O=C1NC(N[C@H]2CCC[C@H](O)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5438325 IC50 19.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4)c3c2s1 CHEMBL2386761 IC50 19.22 nM
O=C(NN=Cc1cc(Br)c(O)c(Br)c1)Nc1ccccc1 CHEMBL1983575 pKi 19.95 nM
COc1cc(/C=C2\N=C(Nc3ccc(N4CCN(C)CC4)cc3)NC2=O)ccc1O CHEMBL5200518 IC50 20.0 nM
CN1CCN(c2ccc(NC3=N/C(=C\C4=COc5ccccc5O4)C(=O)N3)cc2)CC1 CHEMBL5195216 IC50 20.0 nM
CO[C@H]1CCCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5422857 IC50 20.0 nM
CN1CCN(c2ccc(NC3=N/C(=C\c4ccc5c(c4)OCCO5)C(=O)N3)cc2)CC1 CHEMBL5414801 IC50 20.0 nM
COc1ccc(/C=C2\N=C(Nc3ccc(N4CCN(C)CC4)cc3)NC2=O)cc1O CHEMBL5416942 IC50 20.0 nM
COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CCCN)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094456 IC50 21.0 nM
CS(=O)(=O)c1ccc(-c2nccc(-c3c[nH]c4cnccc34)n2)cc1 CHEMBL3421975 IC50 21.0 nM
O=C1NC(N[C@@H]2CCCC[C@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5401675 IC50 21.0 nM
COc1nc(C)nc2[nH]cc(-c3ccnc(N)c3)c12 CHEMBL5081341 IC50 22.0 nM
O=C1NC(Nc2ccc(O)c(F)c2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5181008 IC50 23.0 nM
O=C1NC(N[C@@H]2CCC[C@@H](O)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5420497 IC50 23.0 nM
CO[C@H]1CCC[C@@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5427842 IC50 23.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL5428750 IC50 23.0 nM
O=C1NC(Nc2ccc(O)cc2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL1803085 IC50 24.0 nM
O=C1NC(NC[C@H](O)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430262 IC50 24.0 nM
N=C1NC(=O)/C(=C/c2ccc3c(c2)CCO3)S1 CHEMBL4283751 IC50 24.1 nM
Cc1nc(CN(C)c2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)cs1 CHEMBL1474834 IC50 25.0 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(-c4c[nH]c5cnccc45)n3)cc2)CC1 CHEMBL3421973 IC50 25.0 nM
CN(C)C1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1969151 pKi 25.12 nM
CC(Nc1cncc(-n2cnc3ccc(C#N)cc32)n1)c1ccccc1F CHEMBL1977138 pKi 25.12 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(C(F)(F)F)cc4)c3c2s1 CHEMBL2386769 IC50 25.21 nM
NCCC(NC(=O)c1ccc(Cl)c(NC(=O)c2cc3cnc(N4CCC(N)CC4)nc3[nH]c2=O)c1)c1ccccc1 CHEMBL3094436 IC50 26.0 nM
O=C1NC(NC[C@@H](O)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5428132 IC50 26.0 nM
O=C1NC(N[C@@H]2CCCC[C@@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5437778 IC50 27.0 nM
O=C1NC(NC2CCCSC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5405233 IC50 27.0 nM
COc1ccc2c(c1)[nH]c1c(C)nccc12 CHEMBL269538 IC50 28.0 nM
COc1cccc2c1[nH]c1c3ccncc3cc(C#N)c21 CHEMBL3885431 IC50 28.0 nM
O=C1NC(NC2CCCCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5424272 IC50 28.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 29.0 nM
CC(=O)Nc1cccc(-c2n[nH]c3ncc(-c4ccc(O)c(O)c4)cc23)c1 CHEMBL4875758 IC50 29.0 nM
CO[C@H]1CCC[C@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5436754 IC50 30.0 nM
CN1CCN(CCNc2ncc3cc(C(=O)Nc4cc(C(=O)NC(CCN)c5ccccc5)ccc4Cl)c(=O)[nH]c3n2)CC1 CHEMBL3094435 IC50 31.0 nM
COc1ccc(-c2n[nH]c3ncc(Nc4cccc(O)c4)cc23)cc1 CHEMBL4858785 IC50 31.0 nM
O=C1NC(NC2CCC(F)(F)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5427398 IC50 31.0 nM
O=C1NC(NC2C3CC4CC(C3)CC2C4)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5417207 IC50 31.0 nM
COC(=O)C1(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C2CC3CC(C2)CC1C3 CHEMBL5417890 IC50 31.0 nM
NCC(NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5438728 IC50 31.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5418020 IC50 31.0 nM
NC(=O)c1nc2ccc3ncnc(Nc4ccc(F)cc4Br)c3c2s1 CHEMBL2386759 IC50 31.5 nM
CCn1c(-c2nonc2N)nc2cncc(C(=O)N3CCC(N)C3)c21 CHEMBL1870106 pKi 31.62 nM
COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2 CHEMBL1980391 pKi 31.62 nM
Nc1ccc(-c2cnc3[nH]cc(-c4ccc(O)cc4)c3c2)cc1 CHEMBL4096575 IC50 32.0 nM
CC(=O)Nc1cccc(Nc2ccc3ncc(-c4cccc(NC(C)=O)c4)n3n2)c1 CHEMBL4102871 IC50 32.0 nM
CN1CCN(c2ncc(NC3=N/C(=C\c4ccc5ncsc5c4)C(=O)N3)cn2)CC1 CHEMBL5407057 IC50 32.0 nM
CO[C@@H]1CCCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5428629 IC50 33.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1cc(-c2cn(C)c3cnccc23)ncn1 CHEMBL3421965 IC50 34.0 nM
COc1ccc2c(c1)[nH]c1c3ccncc3cc(C#N)c21 CHEMBL3883660 IC50 34.0 nM
CO[C@@H]1CCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5440139 IC50 34.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C/c2ccc3ncsc3c2)C(=O)N1 CHEMBL5432405 IC50 34.0 nM
CCOC(=N)c1nc2ccc3ncnc(Nc4ccc(Br)cc4F)c3c2s1 CHEMBL3909052 IC50 34.4 nM
O=C1NC(Nc2cccc(F)c2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5196066 IC50 35.0 nM
CO[C@@H]1CCCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5440511 IC50 35.0 nM
O=C1N=C(Nc2ccccc2)N=C1Cc1ccc2c(c1)OCO2 CHEMBL1738733 IC50 37.0 nM
CCOC(=O)c1cccc(-c2cnc3ccc(N[C@@H](CC)CO)nn23)c1 CHEMBL4071322 IC50 37.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL1802358 IC50 37.0 nM
N=C(OCc1ccccc1)c1nc2ccc3ncnc(Nc4ccc5c(c4)OCO5)c3c2s1 CHEMBL2386755 IC50 37.34 nM
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCCC1CCN(Cc2ccc(F)cc2)CC1 CHEMBL4747992 IC50 37.8 nM
Clc1ccc(CNc2nccc(-c3ccc4c(c3)OCO4)n2)cc1Cl CHEMBL1898197 IC50 38.0 nM
CC(=O)Nc1ccc(-c2cnc3[nH]cc(-c4ccc(O)cc4)c3c2)cc1 CHEMBL4078550 IC50 38.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(NC(C)=O)c3)n2n1 CHEMBL4061526 IC50 38.0 nM
O=C1NC(N[C@@H](CO)CC2CCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5402979 IC50 38.0 nM
CC(C)C[C@@H](CO)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5408047 IC50 38.1 nM
COc1ccc2c3ccnc(Cl)c3n(CC#N)c2c1 CHEMBL4283240 IC50 38.4 nM
Oc1cccc(-c2cnc3[nH]nc(-c4cccc(O)c4)c3c2)c1 CHEMBL4863662 IC50 39.0 nM
CCCCC(=O)Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL2006450 pKi 39.81 nM
O=C(NCCc1cccs1)N1CC=C(c2c[nH]c3ncccc23)CC1 CHEMBL1987535 pKi 39.81 nM
COc1ncc2cc(C(=O)Nc3cc(C(=O)NCc4ccsc4)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094452 IC50 40.0 nM
CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1N(C)CCN CHEMBL3103192 IC50 40.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 40.0 nM
COc1nc(C)nc2[nH]cc(-c3ccnc(C)c3)c12 CHEMBL5092245 IC50 40.0 nM
COC(=O)[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)C(C)C CHEMBL5416274 IC50 40.0 nM
COC(=O)[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)C(C)O CHEMBL5401116 IC50 41.0 nM
O=C1NC(NCc2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5405969 IC50 41.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1C CHEMBL5406864 IC50 41.1 nM
c1cc(-c2ccc3c(c2)OCO3)nc(Nc2ccc3c(c2)OCO3)n1 CHEMBL1885536 IC50 42.0 nM
COc1ccc2c(c1)[nH]c1c3c(OC)cncc3cc(C#N)c21 CHEMBL3884821 IC50 42.0 nM
Oc1ccc(-c2c[nH]c3ncc(-c4ccc(-c5nnn[nH]5)cc4)cc23)cc1 CHEMBL4087125 IC50 42.0 nM
Cc1csc(CNC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)n1 CHEMBL5434349 IC50 42.0 nM
O=C(NC1CCCC1)c1ccc(-c2cc(-c3cc4c([nH]3)CCNC4=O)ccn2)cc1 CHEMBL388853 IC50 43.0 nM
O=C1NC(N[C@@H](CO)CC2CCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5422295 IC50 43.0 nM
CC(C)C[C@@H](CF)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5438412 IC50 43.0 nM
NC(=O)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1 CHEMBL3940669 IC50 43.4 nM
O=C1NC(N[C@@H](CO)CC2CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5397157 IC50 44.0 nM
NC[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5441121 IC50 44.0 nM
CO[C@H]1CCCC[C@@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5413743 IC50 45.0 nM
O=C1NC(N[C@H](CO)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429783 IC50 46.0 nM
C#Cc1cccc(Nc2ncnc3ccc4nc(C(=N)OC)sc4c23)c1 CHEMBL3954779 IC50 46.29 nM
O=C1NC(N[C@@H]2CCCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5427523 IC50 47.0 nM
Cc1csc(CN(C)c2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)n1 CHEMBL1704879 IC50 48.0 nM
COc1ncc2cc(C(=O)Nc3cc(C(=O)NCc4ccccc4)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094447 IC50 48.0 nM
O=C1NC(NC(CO)C2CCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5415462 IC50 48.0 nM
O=C1NC(NCC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5422100 IC50 48.0 nM
Oc1cnc2ccc(-c3ccncc3)cc2c1 CHEMBL1973868 pKi 50.12 nM
O=C(Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1)c1c(F)cccc1F CHEMBL1991410 pKi 50.12 nM
Oc1ccc(-c2c[nH]c3ncc(-c4ccc5[nH]ccc5c4)cc23)cc1 CHEMBL4065701 IC50 51.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 CHEMBL4105084 IC50 51.0 nM
O=C1NC(NCC(O)C2CCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5436133 IC50 51.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(C=O)c3)n2n1 CHEMBL4093104 IC50 53.0 nM
Cc1ccc(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)cc1 CHEMBL1803084 IC50 53.0 nM
c1ccc(-c2ccc3[nH]ncc3c2)cc1 CHEMBL3298236 IC50 53.5 nM
COc1ccc(-c2n[nH]c3ncc(Br)cc23)cc1 CHEMBL4849192 IC50 54.0 nM
FC(F)(F)c1ccc2[nH]c(Nc3ncccn3)nc2c1 CHEMBL4755788 IC50 54.8 nM
Clc1ccc(CNc2nccc(-c3ccc4c(c3)OCCO4)n2)cc1Cl CHEMBL1904905 IC50 55.0 nM
Cc1[nH]c2ncc3cc2c1-c1cn(nc1C(F)(F)F)CCCC(=O)N(C)Cc1nn(C)c(C#N)c1-3 CHEMBL5075321 IC50 55.0 nM
CN(C)c1nccc(-c2cnn3ncccc23)n1 CHEMBL4848254 Kd 56.0 nM
Oc1ccc(-c2cnc3[nH]nc(-c4ccccc4)c3c2)cc1 CHEMBL4878881 IC50 56.0 nM
O=C1NC(N[C@@H]2CCC[C@@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5415622 IC50 56.0 nM
Oc1ccc(-c2cnc3[nH]cc(-c4ccc(F)cc4)c3c2)cc1O CHEMBL4292553 IC50 56.8 nM
CO[C@@H]1CCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5408907 IC50 57.0 nM
CO[C@H]1CCC[C@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CC1 CHEMBL5396280 IC50 57.0 nM
O=C1NC(=S)S/C1=C\c1ccc2ncccc2c1 CHEMBL3774448 IC50 60.0 nM
O=C1NC(NCc2ccccn2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5406568 IC50 60.0 nM
O=C1NC(N[C@@H]2CCCCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5439952 IC50 61.0 nM
O=C1NC(Nc2ccccn2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5417527 IC50 61.0 nM
COc1cc(/C=C2\N=C(Nc3ccccc3)NC2=O)ccc1O CHEMBL5195122 IC50 62.0 nM
O=C1NC(Nc2ccc(F)cc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5424064 IC50 62.0 nM
[2H]C1([2H])Oc2ccc(/C=C3\N=C(Nc4ccccc4)NC3=O)cc2O1 CHEMBL5199422 IC50 63.0 nM
O=C1NC(NC2CCC(F)(F)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5432739 IC50 63.0 nM
CCC(=O)Nc1ccc(C(=O)N2CCNCC2)c(O)c1 CHEMBL1988141 pKi 63.1 nM
O=C1NC(NC2CCCCC2)=N/C1=C\c1ccc2ncoc2c1 CHEMBL5394477 IC50 64.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(N(C)C)cc4)c3c2s1 CHEMBL2386768 IC50 64.28 nM
NC(=O)c1cc2c(-c3ccc(C(=O)NCc4ccccc4O)s3)cccc2s1 CHEMBL5203374 Ki 65.3 nM
COC(=O)[C@H](C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5423907 IC50 66.0 nM
CN1CC[C@@](C)(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1=O CHEMBL5429707 IC50 66.0 nM
CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5ccncc5)ccc4n3)cc2)CC1 CHEMBL4531334 IC50 67.0 nM
O=C1NC(NC2CCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430357 IC50 67.0 nM
COC(CNC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)C1CCCCC1 CHEMBL5423402 IC50 67.0 nM
Cn1ncc2cccc(NC3=N/C(=C\c4ccc5ncsc5c4)C(=O)N3)c21 CHEMBL5394513 IC50 67.0 nM
Cn1cc(-c2csc(-c3cncc(NC(=O)C4CC4)c3)c2)cn1 CHEMBL4292442 IC50 67.1 nM
COc1ncc2cc(C(=O)Nc3cc(C(=O)NCc4cccc(Cl)c4)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094448 IC50 68.0 nM
Cn1cnc2ccc(/C=C3\N=C(NC4CCCCCC4)NC3=O)cc21 CHEMBL5423245 IC50 69.0 nM
O=C1NC(N[C@@H](CO)Cc2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5435490 IC50 69.0 nM
CCCCOC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1 CHEMBL3916163 IC50 69.4 nM
c1cncc(-c2csc(-c3cncs3)c2)c1 CHEMBL3597991 IC50 70.0 nM
O=C1NC(=S)S/C1=C\c1ccc2ncsc2c1 CHEMBL3775393 IC50 70.0 nM
COC(CNC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5424074 IC50 70.0 nM
COCC(Cc1ccccc1)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5406461 IC50 71.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3c(c2)CCO3)C(=O)N1 CHEMBL5395833 IC50 71.6 nM
COC(=N)c1nc2ccc3ncnc(Nc4cccc(C#N)c4)c3c2s1 CHEMBL2386750 IC50 71.98 nM
NCCOCCOCCOCCOc1ccc(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)cc1 CHEMBL3092863 IC50 72.0 nM
CCSC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL5181355 IC50 72.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3nc(C)sc3c2)C(=O)N1 CHEMBL5435195 IC50 72.1 nM
O=C(Nc1cncc(-c2cc(-c3cccnc3)cs2)c1)C1CC1 CHEMBL4283503 IC50 72.9 nM
CN(Cc1cccs1)c1ncnc2ccc(-c3ccc4c(c3)OCO4)cc12 CHEMBL1591577 IC50 73.0 nM
C[C@@H]1CCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5433142 IC50 73.0 nM
COC(=O)[C@H](Cc1ccccc1)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5434955 IC50 73.0 nM
O=C1NC(N[C@@H]2CCCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5397281 IC50 74.0 nM
COc1ncc2cc(C(=O)Nc3cc(C(N)=O)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094444 IC50 75.0 nM
Cc1ccc(CNC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)c(C)c1 CHEMBL5423063 IC50 78.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3nn(C)cc3c2)C(=O)N1 CHEMBL5422963 IC50 78.3 nM
Cc1n[nH]cc1-c1cc2nc([C@@H]3CCCCN3)[nH]c(=O)c2s1 CHEMBL4439133 IC50 78.6 nM
CO[C@@H]1Cc2ccccc2[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5414635 IC50 79.0 nM
NC(=O)c1ccc2nc(-c3ccc([N+](=O)[O-])o3)cn2c1 CHEMBL1973359 pKi 79.43 nM
O=C(O)c1nc2ccccc2c2[nH]c3c(Br)cccc3c12 CHEMBL3589661 IC50 80.0 nM
O=C1NC(=O)/C(=C/c2ccc3nccnc3c2)S1 CHEMBL568150 IC50 80.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(/C=N/O)c3)n2n1 CHEMBL4065432 IC50 80.0 nM
CCNc1cc(Nc2ccc(C(=O)N3CCC(N4CCOCC4)CC3)cc2OC)nc2[nH]cc(C(F)(F)F)c12 CHEMBL5273528 IC50 80.5 nM
COCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3c2-c2sncc2CC3)cn1 CHEMBL4066819 Kd 81.0 nM
CO[C@H]1CCCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5411157 IC50 81.0 nM
CO[C@H]1CCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CC1 CHEMBL5429272 IC50 81.0 nM
CC[C@H](CO)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5426049 IC50 81.0 nM
CCOC(=O)c1c(/C(C#N)=C\N)c2ccc(Cl)c(Cl)c2n1C CHEMBL1236620 IC50 81.2 nM
O=C1NC(Nc2cccnc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5427325 IC50 82.0 nM
CC(C)(C)CNc1ncnc2ccc(-c3ccc4c(c3)OCO4)cc12 CHEMBL1551169 IC50 83.0 nM
Oc1ccc(-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)cc1 CHEMBL4084605 IC50 83.0 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL428690 Kd 84.0 nM
COC(=N)c1nc2ccc3ncnc(N(C)c4ccc(OC)cc4)c3c2s1 CHEMBL3906791 IC50 84.94 nM
CN1CCN(c2ccc(Nc3cc(-c4c[nH]c5ccccc45)ncn3)cc2)CC1 CHEMBL3421636 IC50 85.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3n2)C(=O)N1 CHEMBL5429359 IC50 85.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3nn(C)cc3c2)C(=O)N1C CHEMBL5422667 IC50 85.6 nM
Cn1cc(C2=C(c3cccc(NCC(O)CO)c3)C(=O)NC2=O)c2cc(F)ccc21 CHEMBL1082152 Kd 87.0 nM
Oc1ccc(-c2n[nH]c3ncc(Br)cc23)cc1 CHEMBL4871412 IC50 87.0 nM
Cn1cnc2ccc(/C=C3\N=C(NC4CCCCC4)NC3=O)cc21 CHEMBL5394278 IC50 87.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2c(c1)CCO2 CHEMBL5208980 IC50 88.0 nM
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5cncc(-c6cccc(F)c6)c5[nH]4)c3c2)c1 CHEMBL4297639 IC50 89.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(SC)c3)n2n1 CHEMBL4089652 IC50 90.0 nM
CCCSC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL5206143 IC50 90.0 nM
O=C1NC(N[C@@H](CO)CC2CCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5431535 IC50 91.0 nM
Cc1ccc(C)c(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)c1 CHEMBL5179457 IC50 92.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2ncoc2c1 CHEMBL5438293 IC50 92.0 nM
c1cncc(CNc2nccc(-c3ccc4[nH]ncc4c3)n2)c1 CHEMBL1902528 IC50 93.0 nM
COc1ccc2c(n1)[nH]c1c3ccncc3cc(C#N)c21 CHEMBL3885316 IC50 93.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(C(C)(C)C)cc4)c3c2s1 CHEMBL2386767 IC50 93.84 nM
Cc1nc2ccc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)cc2s1 CHEMBL5407040 IC50 95.0 nM
COc1ncc2cc(C(=O)Nc3cc(C(=O)NCc4cccs4)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094451 IC50 96.0 nM
COc1ccc(-c2n[nH]c3ncc(-c4ccc(OC)c(OC)c4)cc23)cc1 CHEMBL4874455 IC50 97.0 nM
O=C1NC(N[C@@H]2CCC[C@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5393925 IC50 97.0 nM
O=C(NC1CCCC1)c1ccc(-c2nccc(-c3c[nH]c4cnccc34)n2)cc1 CHEMBL3421974 IC50 98.0 nM
CCCn1cc(-c2csc(-c3cncc(NC(=O)C4CC4)c3)c2)cn1 CHEMBL4287083 IC50 98.8 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3[nH]cnc3c2)C(=O)N1C CHEMBL5429691 IC50 98.9 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3c2s1 CHEMBL3970062 IC50 99.34 nM
C#Cc1cn(C2CCCC2)c2ncnc(N)c12 CHEMBL1993877 pKi 100.0 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCCCN(C)C)cc2NC3=O)ccc1O CHEMBL1996702 pKi 100.0 nM
Oc1cc(O)cc(C=Cc2ccc(O)c(O)c2)c1 CHEMBL1972346 pKi 100.0 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)s1 CHEMBL1983715 pKi 100.0 nM
CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O CHEMBL189963 pKi 100.0 nM
OCc1cc(-c2ccc3[nH]ncc3c2)on1 CHEMBL1974617 pKi 100.0 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1979690 pKi 100.0 nM
CC(=O)c1cc2cc(O)ccc2s1 CHEMBL3335363 IC50 100.0 nM
COc1ccc2c(/C(C#N)=C/c3cccnc3)c[nH]c2n1 CHEMBL3884570 IC50 100.0 nM
CCN1/C(=C\C(C)=O)Sc2ccc(OC)cc21 CHEMBL1349996 Kd 100.0 nM
O=C1NC(Nc2ccc(F)cc2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5180765 IC50 100.0 nM
COc1nc(C)c2cc(C(=O)Nc3cc(C(=O)NC(CCN)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094439 IC50 101.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncn(C)c3c2)C(=O)N1 CHEMBL5414174 IC50 102.4 nM
Cn1ccc(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)n1 CHEMBL5407529 IC50 103.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 107.0 nM
O=C1NC(NC2CCCCCC2)=N/C1=C\c1ccc2[nH]ncc2c1 CHEMBL5413427 IC50 107.0 nM
NCCOCCOCCOc1ccc(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)cc1 CHEMBL3092862 IC50 110.0 nM
CC[C@@H](CO)/N=C/c1cccc(-c2cnc3ccc(N[C@@H](CC)CO)nn23)c1 CHEMBL4070227 IC50 110.0 nM
CC[C@H](CO)/N=C/c1cccc(-c2cnc3ccc(N[C@H](CC)CO)nn23)c1 CHEMBL4084919 IC50 110.0 nM
CC(C)c1cnn2c(NCc3ccc(-c4ccccn4)cc3)nc(N[C@H]3CC[C@H](N)CC3)nc12 CHEMBL4284209 IC50 110.0 nM
Brc1ccc(CNc2nccc(-c3ccc4c(c3)OCO4)n2)cc1Br CHEMBL1899256 IC50 112.0 nM
O=C1NC(N[C@H]2CC[C@H](O)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5422936 IC50 113.0 nM
CC1(C)CCC(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CO1 CHEMBL5436147 IC50 113.0 nM
O=C1NC(N[C@@H]2c3ccccc3C[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5398161 IC50 115.0 nM
O=C1NC(Nc2nncs2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5424295 IC50 115.0 nM
O=C1NC(N[C@H]2CN3CCC2CC3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5428107 IC50 115.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3[nH]ncc3c2)C(=O)N1 CHEMBL5432194 IC50 115.4 nM
C[C@]12CC3CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C1)C[C@@](C)(C3)C2 CHEMBL5435495 IC50 117.0 nM
CNC(=O)c1sc(-c2ccnc(NC(=O)CNCCNc3c4c(nc5ccccc35)CCCC4)c2)nc1OCC1CC1 CHEMBL4789145 IC50 119.7 nM
Brc1cnc2[nH]nc(-c3cnn(Cc4ccccc4)c3)c2c1 CHEMBL4868377 IC50 121.0 nM
O=C1NC(N[C@H]2CCCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5413726 IC50 123.0 nM
O=C1NC(NC2COCCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5421636 IC50 124.0 nM
Clc1ccc(CNc2nccc(-c3ccc4[nH]ncc4c3)n2)cc1Cl CHEMBL1892019 IC50 125.0 nM
Cn1cc2cc(/C=C3\N=C(NC4CCCCCC4)NC3=O)ccc2n1 CHEMBL5425792 IC50 125.0 nM
N#Cc1ccc2c(c1)C(c1ccc3c(n1)CCCC3O)C(=O)N2 CHEMBL1985681 pKi 125.89 nM
CN1CCC(c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)C(O)C1 CHEMBL422897 pKi 125.89 nM
O=C(Nc1ccc(O)cc1)c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1 CHEMBL4080994 IC50 128.0 nM
O=C1NC(N[C@@H]2COCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5431345 IC50 128.0 nM
CCN1/C(=C/C(C)=O)Sc2ccc(OC)cc21 CHEMBL408982 Kd 130.0 nM
c1coc(CCNc2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)c1 CHEMBL1357975 IC50 130.0 nM
CS(=O)(=O)Nc1ccc(-c2cnc3[nH]cc(-c4ccc(O)cc4)c3c2)cc1 CHEMBL4088888 IC50 130.0 nM
CC(C)[C@@H](CO)Nc1ccc2ncc(-c3cccnc3)n2n1 CHEMBL4074132 IC50 130.0 nM
CC[C@@H](CO)N(C(C)=O)c1ccc2ncc(-c3cccc(NC(C)=O)c3)n2n1 CHEMBL4092673 IC50 130.0 nM
O=C(Nc1ccc(C(=O)NCc2ccccc2)cc1)Nc1nc2ccc(O)cc2s1 CHEMBL4277134 IC50 130.0 nM
Nc1cncc(-c2csc(-c3cccnc3)c2)c1 CHEMBL4282261 IC50 130.0 nM
O=C1NC(N[C@@H]2CCC[C@H](O)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5403037 IC50 131.0 nM
O=C(Nc1cncc(-c2cc(-c3cccnc3)cs2)c1)C1CCNC1 CHEMBL4290096 IC50 131.7 nM
CO[C@@H]1CCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5394394 IC50 132.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3[nH]ncc3c2)C(=O)N1C CHEMBL5415554 IC50 133.8 nM
COC(=O)c1ccc(Cl)c(NC(=O)c2cc3cnc(OC)nc3[nH]c2=O)c1 CHEMBL3094442 IC50 134.0 nM
COc1ncc2cc(C(=O)Nc3cc(C(=O)NCCc4cccc(Cl)c4)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094449 IC50 135.0 nM
FC(F)(F)c1cc(Br)cc(Nc2nccc(-c3ccc4c(c3)OCO4)n2)c1 CHEMBL2392368 IC50 137.0 nM
O=C(Nc1cccc(O)c1)c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1 CHEMBL4105239 IC50 138.0 nM
O=C(Nc1cncc(-c2cc(-c3cn[nH]c3)cs2)c1)C1CC1 CHEMBL4278353 IC50 138.0 nM
COc1cc(OC2CCN(C)CC2)ccc1Nc1nccc(-c2c[nH]c3cnccc23)n1 CHEMBL3421972 IC50 140.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(S(C)(=O)=O)c3)n2n1 CHEMBL4070189 IC50 140.0 nM
COc1ncc(-c2n[nH]c3ncc(Br)cc23)cn1 CHEMBL4855883 IC50 141.0 nM
O=C1NC(NC2CCCCCC2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5410991 IC50 141.0 nM
COc1c2c(nn1C)CN(C(C)C)C(=O)CCCn1cc(c(C(F)(F)F)n1)-c1c[nH]c3ncc-2cc13 CHEMBL5081601 IC50 146.0 nM
O=C1NC(N[C@H]2CCCCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5423580 IC50 146.0 nM
COc1cc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)c(OC)c2)ccc1O CHEMBL140 IC50 147.7 nM
COc1ccc(CNC(=O)c2cnc3ccc(-c4ccc5ncccc5c4)cn23)cc1 CHEMBL4853178 IC50 148.0 nM
CN1Cc2nn(C)cc2-c2cnc3[nH]cc(c3c2)-c2cnn(c2)CCCCC1=O CHEMBL5079894 IC50 150.0 nM
O=C1NC(N[C@@H]2CCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429789 IC50 152.0 nM
O=C1NC(NC2CC3(CCC3)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5427895 IC50 153.0 nM
O=C1NC(NCCCn2ccnc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5398474 IC50 154.0 nM
Nc1cncc(-c2cc(-c3cccnc3)cs2)c1 CHEMBL4281037 IC50 154.3 nM
O=C1NC(NC2CCCCC2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5395680 IC50 156.0 nM
CNC(=O)c1ccc(Nc2nc(OC3CCCC3)c3c(-c4ccc5nc(C)oc5c4)c[nH]c3n2)c(OC)c1 CHEMBL4062218 IC50 157.0 nM
Cc1ccccc1-c1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 CHEMBL2000029 pKi 158.49 nM
CCN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1967998 pKi 158.49 nM
CC(N)C1CCC(C(=O)Nc2ccnc3[nH]ccc23)CC1 CHEMBL2002992 pKi 158.49 nM
Cc1ccc(Nc2nc3ccc([N+](=O)[O-])cc3[nH]2)nc1 CHEMBL1992937 pKi 158.49 nM
CN1c2ccc(N)cc2C(c2ccccc2)c2cc(N)ccc21 CHEMBL1991734 pKi 158.49 nM
O=C1NC(NCC2CCOCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5425492 IC50 159.0 nM
N#Cc1cc2cnccc2c2[nH]c3ncccc3c12 CHEMBL3884015 IC50 160.0 nM
Cc1ccc(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)c(C)c1 CHEMBL5170033 IC50 160.0 nM
O=C1NC(NCc2ccncc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5434728 IC50 160.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)c(OC)c4)c3c2s1 CHEMBL3921110 IC50 160.6 nM
O=C1NC(NC2CCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5439694 IC50 162.0 nM
CC[C@@H](CO)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5437946 IC50 162.0 nM
O=C1NC(NCc2cccnc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5395707 IC50 163.0 nM
COc1ncc(-c2n[nH]c3ncc(-c4ccc(OC)c(OC)c4)cc23)cn1 CHEMBL4867616 IC50 167.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3c(c2)CCO3)C(=O)N1C CHEMBL5415238 IC50 169.9 nM
COc1ccc2ncc(-c3cccc(/C=N/O)c3)n2n1 CHEMBL4072506 IC50 170.0 nM
Oc1ccc(-c2cnc3[nH]cc(-c4ccc(-c5nnn[nH]5)cc4)c3c2)cc1 CHEMBL4102553 IC50 172.0 nM
CC(C)(C)OC[C@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5411626 IC50 175.0 nM
c1cncc(CNc2ccnc(-c3ccc4[nH]ncc4c3)n2)c1 CHEMBL1884711 IC50 179.0 nM
CN(Cc1nccs1)c1ncnc2ccc(-c3ccc4c(c3)OCO4)cc12 CHEMBL1396483 IC50 180.0 nM
CC(=O)Nc1cccc(Nc2ccc3ncc(-c4cccc(Cl)c4)n3n2)c1 CHEMBL4074499 IC50 180.0 nM
O=C1NC(NC2CCCCCC2)=N/C1=C\c1ccc2[nH]cnc2c1 CHEMBL5408457 IC50 186.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(N5CCCC5)cc4)c3c2s1 CHEMBL3982462 IC50 186.4 nM
NC(=O)c1cc2c(-c3ccc(C(=O)NCc4ccc(N)cc4)s3)cccc2s1 CHEMBL5199700 Ki 186.6 nM
COc1ccc(-c2n[nH]c3ncc(Nc4ccccc4)cc23)cc1 CHEMBL4850955 IC50 188.0 nM
CCN1/C(=C/C(C)=O)Sc2ccc(O)cc21 CHEMBL1232500 IC50 188.8 nM
COC(=O)[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5405680 IC50 189.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(C(F)(F)F)c3)n2n1 CHEMBL4086402 IC50 190.0 nM
NC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL5203292 IC50 190.0 nM
COc1cccc(-c2n[nH]c3ncc(Nc4cccc(O)c4)cc23)c1 CHEMBL4858250 IC50 191.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncn(C)c3c2)C(=O)N1C CHEMBL5397088 IC50 192.8 nM
COC(=O)[C@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5428794 IC50 194.0 nM
O=C1NC(N[C@H]2CCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5424363 IC50 196.0 nM
O=[N+]([O-])c1ccc(-c2cnc3[nH]cc(-c4ccc(O)cc4)c3c2)cc1 CHEMBL4075959 IC50 198.0 nM
CCCCNc1nc(N)c(C(=O)c2ccccc2)s1 CHEMBL2007479 pKi 199.53 nM
CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 CHEMBL296468 Kd 200.0 nM
O=C(c1cccc(O)c1)c1cc2cc(O)ccc2s1 CHEMBL3335350 IC50 200.0 nM
Cc1ccc(C(=O)c2cc3cc(O)ccc3s2)cc1O CHEMBL3335356 IC50 200.0 nM
O=C1NC(Nc2ccccn2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5206744 IC50 200.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2c(c1)CCO2 CHEMBL5394613 IC50 200.0 nM
Cc1cnc(CNC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)cn1 CHEMBL5422096 IC50 200.0 nM
O=C1NC(NC2CCCCC2)=N/C1=C\c1ccc2[nH]cnc2c1 CHEMBL5437222 IC50 203.0 nM
COc1ccc2sc(C(=O)N(C)Cc3cccc(F)c3)cc2c1 CHEMBL4082113 IC50 206.0 nM
CO[C@H]1CCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5395027 IC50 206.0 nM
CCN1C(=O)/C(=C/c2ccc3ncsc3c2)N=C1N[C@@H](COC)CC(C)C CHEMBL5433334 IC50 207.3 nM
O=C(O)c1nc2ccccc2c2[nH]c3c(Cl)cccc3c12 CHEMBL3589660 IC50 210.0 nM
CC(C)OC(=O)c1nc2ccc3ncnc(Nc4ccc5c(c4)OCO5)c3c2s1 CHEMBL3921510 IC50 217.8 nM
c1cc(OCCN2CCCCC2)cc(-c2n[nH]c3ccc(-c4nnc[nH]4)cc23)c1 CHEMBL1614713 IC50 218.2 nM
O=C(Nc1cncc(-c2cc(-c3cccnc3)cs2)c1)C1CCC1 CHEMBL4294080 IC50 218.8 nM
CC(C)C[C@H](COCc1ccccc1)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5428588 IC50 219.0 nM
COc1ccc2[nH]c3c4ccncc4cc(C#N)c3c2c1 CHEMBL3883639 IC50 220.0 nM
COc1ccc2c(-c3ccncc3)c[nH]c2n1 CHEMBL3883448 IC50 220.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cc4ccccc4[nH]3)n2n1 CHEMBL4062820 IC50 220.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2nnsc2c1 CHEMBL5434048 IC50 220.0 nM
CO[C@H]1CC[C@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CC1 CHEMBL5429086 IC50 220.0 nM
Cc1nc2ccc(/C=C3\N=C(NC4CCCCCC4)NC3=O)cc2s1 CHEMBL5435753 IC50 222.0 nM
O=C1NC(NCCc2ccccn2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5401073 IC50 223.0 nM
O=C1NC(NCC(O)Cc2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5398512 IC50 224.0 nM
O=C1CC[C@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CN1 CHEMBL5433242 IC50 225.0 nM
COc1ccc2c(c1)nc(C(=O)O)c1c3cccc(Br)c3[nH]c21 CHEMBL3589666 IC50 230.0 nM
CCN(Cc1cccs1)c1ncnc2ccc(-c3ccc4c(c3)OCO4)cc12 CHEMBL1515144 IC50 231.0 nM
COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CCN(C)C)c4cccc(Cl)c4)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094465 IC50 233.0 nM
NC(=O)c1cc2c(-c3ccc(C(=O)NCc4ccccc4N)s3)cccc2s1 CHEMBL5186861 Ki 237.9 nM
O=C1NC(N[C@@H]2CCCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5417693 IC50 238.0 nM
CNCC(NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5439276 IC50 239.0 nM
N#C/C(=C\c1cccnc1)c1c[nH]c2ncccc12 CHEMBL3753668 IC50 240.0 nM
O=C1NC(N[C@@H]2CCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5425635 IC50 244.0 nM
CN1CCN(c2cnc(NC3=N/C(=C\c4ccc5ncsc5c4)C(=O)N3)cn2)CC1 CHEMBL5426807 IC50 245.0 nM
CNC(=O)c1ccc(Cl)c(NC(=O)c2cc3cnc(OC)nc3[nH]c2=O)c1 CHEMBL3094445 IC50 248.0 nM
O=C1NC(NC2CCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429595 IC50 249.0 nM
COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N CHEMBL384304 Kd 250.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2c(c1)OCCO2 CHEMBL5194689 IC50 250.0 nM
O=C1NC(N[C@@H]2CCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5423395 IC50 250.0 nM
CCN1CCN(c2ccc(Nc3ncc(C#N)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1973516 pKi 251.19 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(C=Cc3ccccc3)n2)n[nH]1 CHEMBL1983923 pKi 251.19 nM
NC(Cc1c[nH]c2ccccc12)C(=O)Nc1cncc(C=Cc2ccncc2)c1 CHEMBL1983945 pKi 251.19 nM
c1nc(-c2ccc3c(c2)OCO3)c2cc[nH]c2n1 CHEMBL2004515 pKi 251.19 nM
Nc1ccc(-c2cc(-c3cccnc3)cs2)cn1 CHEMBL4285559 IC50 251.4 nM
COC(=O)c1ccc(C)c(NC(=O)c2cc3cnc(OC)nc3[nH]c2=O)c1 CHEMBL3094441 IC50 252.0 nM
O=C1NC(NC2CCOCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430718 IC50 252.0 nM
C[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)C1CCCCC1 CHEMBL5430485 IC50 255.0 nM
CC(=O)Nc1cccc(-c2n[nH]c3ncc(Br)cc23)c1 CHEMBL4866954 IC50 257.0 nM
N#Cc1cc2ccncc2c2[nH]c3ccccc3c12 CHEMBL3883820 IC50 260.0 nM
Cc1ccc(CNC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)o1 CHEMBL5439185 IC50 261.0 nM
O=c1c2c(O)cc(O)cc2oc2c(O)ccc(O)c12 CHEMBL184574 IC50 268.3 nM
CC(C)C[C@H](COCc1ccc(F)cc1)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5416161 IC50 269.0 nM
COc1ccc(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)cc1 CHEMBL1802355 IC50 270.0 nM
O=C1NC(Nc2cncnc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5407276 IC50 271.0 nM
NC(=O)c1cc2c(-c3ccc(C(=O)NCc4ccccc4)s3)cccc2s1 CHEMBL5177156 Ki 277.9 nM
CO[C@H]1CCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5425381 IC50 278.0 nM
COc1ccc(-c2cnc3[nH]nc(-c4cccc(NC(C)=O)c4)c3c2)cc1OC CHEMBL4871570 IC50 287.0 nM
O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl CHEMBL445813 Kd 290.0 nM
CCc1cc2c(cc1-c1cccc(S(=O)(=O)F)c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL4468747 IC50 293.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3nc(C)sc3c2)C(=O)N1C CHEMBL5421052 IC50 295.0 nM
COC[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5401217 IC50 296.0 nM
O=C(Nc1cncc(-c2cc(-c3cccnc3)cs2)c1)c1c(F)cc(F)cc1F CHEMBL4283474 IC50 298.5 nM
CN1CC[C@](C)(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1=O CHEMBL5428562 IC50 299.0 nM
O=C1NC(=S)S/C1=C\c1ccc2c(c1)CCO2 CHEMBL3774830 IC50 300.0 nM
N#Cc1cc2cnccc2c2[nH]c3ccc(F)cc3c12 CHEMBL3883414 IC50 300.0 nM
c1cncc(-c2csc(-c3cccnc3)c2)c1 CHEMBL4280981 IC50 300.0 nM
Cc1ccsc1CN(C)c1ncnc2ccc(-c3ccoc3)cc12 CHEMBL1612677 IC50 304.0 nM
COc1ccc(-c2n[nH]c3ncc(Nc4cccc(OCc5ccccc5)c4)cc23)cc1 CHEMBL4874497 IC50 309.0 nM
CCCNC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL1803079 IC50 310.0 nM
c1nc(NCC2CCCC2)c2cc(-c3ccc4c(c3)OCO4)ccc2n1 CHEMBL1354134 IC50 313.0 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 316.23 nM
COc1ccc(C2=NNc3cccc4c(OC)ccc2c34)cc1OC CHEMBL1997335 pKi 316.23 nM
N#Cc1ccc(-c2ccncc2)cc1NCc1ccccc1 CHEMBL1967992 pKi 316.23 nM
COc1cc(-c2ccc3c(c2)Nc2c(O)cccc2NC3=O)ccc1O CHEMBL550418 pKi 316.23 nM
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCCC3CCO)nc12 CHEMBL2006674 pKi 316.23 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 316.23 nM
O=C(Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1)c1ccccc1 CHEMBL1993413 pKi 316.23 nM
Cc1cccc(N(C)c2nccc(-c3cnn4ncccc34)n2)c1 CHEMBL4637319 IC50 317.1 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc(O)c(O)c1 CHEMBL5191942 IC50 320.0 nM
COC(CNC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)Cc1ccccc1 CHEMBL5421200 IC50 322.0 nM
O=C(Cc1ccccc1)Nc1cncc(-c2cc(-c3cccnc3)cs2)c1 CHEMBL4282366 IC50 326.3 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 330.0 nM
Cn1nc(-c2cnc(N)c(-c3ccc(C(N)=O)c(F)c3)n2)nc1C1(c2ccccc2)CC1 CHEMBL4101902 IC50 330.0 nM
CSC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL5187753 IC50 330.0 nM
Cc1n[nH]c2ccc(-c3nnc4n3[C@H](c3ccc(Cl)cc3)CC4)cc12 CHEMBL5434183 Kd 330.0 nM
CCNCc1ccc(-c2ccc3ncnc(NCC(C)(C)C)c3c2)o1 CHEMBL1770624 IC50 333.0 nM
CC(C)[C@@H]1CC[C@@H](C)C[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5406527 IC50 337.0 nM
O=C1NC(N[C@H]2COCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5396752 IC50 340.0 nM
CC(C)C[C@H](COC(C)(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5398683 IC50 342.0 nM
COc1c(O)ccc2c(=O)c3c(O)cc4c(c3[nH]c12)C=CC(C)(C)O4 CHEMBL3297832 IC50 350.0 nM
COC[C@@H](C)N[C@H]1CC[C@H](Nc2cc(-c3cccc(NCC4(C#N)CCOCC4)n3)c(Cl)cn2)CC1 CHEMBL3656841 IC50 350.0 nM
Cc1ccsc1CN(C)c1ncnc2ccc(-c3ccc(CO)o3)cc12 CHEMBL1476609 IC50 352.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3c(cnn3C)c2)C(=O)N1 CHEMBL5420112 IC50 357.9 nM
Cn1ncc2cc(/C=C3\N=C(NC4CCCCC4)NC3=O)ccc21 CHEMBL5401658 IC50 358.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2c(c1)CCCO2 CHEMBL5207974 IC50 360.0 nM
CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Cc3cn4cc(-c5ccncc5)ccc4n3)cc2)CC1 CHEMBL5288391 IC50 363.9 nM
NC(=O)c1cc2c(-c3ccc(C(=O)NCc4cccc(O)c4)s3)cccc2s1 CHEMBL5180428 Ki 369.8 nM
O=C(Nc1cccc(O)c1)Nc1nc2ccc(O)cc2s1 CHEMBL4283894 IC50 370.0 nM
CN(C)CC#Cc1ccc2[nH]c3c(c2c1)-c1nc(N)ncc1CCC3 CHEMBL5174830 IC50 380.0 nM
O=C(Cc1ccc(F)cc1)Nc1cncc(-c2cc(-c3cccnc3)cs2)c1 CHEMBL4290247 IC50 383.0 nM
O=C(Nc1ccc2[nH]ncc2c1)c1csc(Nc2ccccc2)n1 CHEMBL5284529 IC50 384.4 nM
O=C1NC(NC2CCCCC2)=N/C1=C\c1ccc2c(c1)CCO2 CHEMBL5419006 IC50 391.0 nM
O=C1NC(NC2CCCCCC2)=N/C1=C\c1ccc2c(c1)CCO2 CHEMBL5425748 IC50 396.0 nM
O=C1NC(N[C@H]2CCCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429703 IC50 397.0 nM
NC(=O)c1cc2c(-c3ccc(Br)cc3)cncc2s1 CHEMBL1978195 pKi 398.11 nM
CC(C)(C)Nc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1995211 pKi 398.11 nM
COc1c(-c2nc3ccccc3[nH]2)c(O)cc2oc(C)cc(=O)c12 CHEMBL1972355 pKi 398.11 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc([N+](=O)[O-])cc2)n1 CHEMBL242865 pKi 398.11 nM
COc1ccccc1CNC(=N)Nc1nccc(-c2cccs2)n1 CHEMBL1997197 pKi 398.11 nM
N#Cc1ccc2nc(N)n(-c3nccs3)c2c1 CHEMBL1988805 pKi 398.11 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 398.11 nM
O=C1Nc2cc(-c3ccc(O)cc3)ccc2C1=Cc1ccc[nH]1 CHEMBL1980329 pKi 398.11 nM
O=C(c1cc2cc(O)ccc2s1)c1cc(O)ccc1F CHEMBL3335358 IC50 400.0 nM
O=C(c1ccc(F)c(O)c1)c1cc2cc(O)ccc2s1 CHEMBL3335359 IC50 400.0 nM
COc1ccc2sc(-c3cncc(NC(C)=O)c3)nc2c1 CHEMBL5288595 IC50 405.2 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3ccsc3)n2n1 CHEMBL4097368 IC50 410.0 nM
COc1cc(/C=C2\N=C(Nc3ccc(N4CCCCC4)cc3)NC2=O)ccc1O CHEMBL5181028 IC50 410.0 nM
COc1ccc(-c2ccnc(NCc3ccc(Cl)c(Cl)c3)n2)cc1 CHEMBL2392360 IC50 411.0 nM
Cn1ncc2cc(/C=C3\N=C(NC4CCCCCC4)NC3=O)ccc21 CHEMBL5409493 IC50 412.0 nM
COC(=O)[C@@H](Cc1ccccc1)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5416947 IC50 419.0 nM
c1csc(CNc2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)c1 CHEMBL567331 Kd 430.0 nM
Cc1occc1CNc1ncnc2ccc(-c3ccc4c(c3)OCO4)cc12 CHEMBL1476499 IC50 431.0 nM
O=C1NC(N2CCCCC2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5201763 IC50 440.0 nM
c1csc(CNc2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)n1 CHEMBL1705549 IC50 446.0 nM
NC(=O)c1cc2c(-c3ccc(C(=O)NCCn4cc(CO)nn4)s3)cccc2s1 CHEMBL5189902 Ki 447.5 nM
CN(Cc1ccco1)c1ncnc2ccc(-c3ccc4c(c3)OCO4)cc12 CHEMBL1374544 IC50 452.0 nM
CC1(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CCNC1=O CHEMBL5423406 IC50 457.0 nM
c1nc(NCC2CCCO2)c2cc(-c3ccc4c(c3)OCO4)ccc2n1 CHEMBL1552755 IC50 458.0 nM
COc1cccc2c1[nH]c1c3ccncc3cc(C(N)=O)c21 CHEMBL3884627 IC50 460.0 nM
CN1CCCC(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5420670 IC50 477.0 nM
CCNC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL1803082 IC50 480.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4cc(OC)c(OC)c(OC)c4)c3c2s1 CHEMBL2386758 IC50 485.8 nM
O=C1NC(NC2CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5400270 IC50 488.0 nM
CNC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL5200677 IC50 500.0 nM
CCCCN(CCC#N)C(=O)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1983348 pKi 501.19 nM
Clc1cc(NC2CCCCC2)nc(-c2c[nH]c3ncccc23)n1 CHEMBL1997846 pKi 501.19 nM
CN(Cc1cc(Cl)c(O)c2ncccc12)C1CCCCC1 CHEMBL1982413 pKi 501.19 nM
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 CHEMBL2006765 pKi 501.19 nM
Cc1ccsc1CNc1ncnc2ccc(-c3ccc4c(c3)OCO4)cc12 CHEMBL1396654 IC50 506.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccnc3)n2n1 CHEMBL4100956 IC50 510.0 nM
Clc1ccc(CNc2ccnc(-c3ccc4[nH]ncc4c3)n2)cc1Cl CHEMBL1898211 IC50 514.0 nM
OCCN1CCN(c2ccc3ncc(-c4cccc(Cl)c4)n3n2)CC1 CHEMBL4071013 IC50 520.0 nM
Cc1ccc(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)cc1C CHEMBL5172170 IC50 520.0 nM
O=C1NC(NC2COC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5412372 IC50 521.0 nM
O=C1NC(Nc2ncccn2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5409992 IC50 523.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4cc(OC)cc(OC)c4)c3c2s1 CHEMBL3960099 IC50 530.9 nM
COc1c2c(nn1C)CN(C(C)C)C(=O)CCCn1cc(c(C(F)(F)F)n1)-c1c(C)[nH]c3ncc-2cc13 CHEMBL5086482 IC50 533.0 nM
c1coc(CNc2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)c1 CHEMBL1725513 IC50 534.0 nM
COc1ccc(/C=C2\N=C(Nc3ccccc3)NC2=O)cc1 CHEMBL5205157 IC50 550.0 nM
CCCNC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1C CHEMBL1802843 IC50 550.0 nM
COC(=O)c1ccc(C)c(NC(=O)c2cc3cc(OC)c(OC)cc3[nH]c2=O)c1 CHEMBL3094440 IC50 560.0 nM
Cn1cc2cc(/C=C3\N=C(NC4CCCCC4)NC3=O)ccc2n1 CHEMBL5396119 IC50 562.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3nnsc3c2)C(=O)N1 CHEMBL5406490 IC50 564.0 nM
CC(=O)Nc1ccc(-c2n[nH]c3ncc(Br)cc23)cc1 CHEMBL4851954 IC50 568.0 nM
COc1cccc(-c2n[nH]c3ncc(Nc4ccccc4)cc23)c1 CHEMBL4850894 IC50 575.0 nM
NC(=O)c1cc2c(-c3ccc(C(=O)NCc4ccccc4N)s3)c(Cl)ccc2s1 CHEMBL5176835 Ki 576.9 nM
COc1ncc2cc(C(=O)Nc3cc(C(=O)N(C)Cc4cccc(Cl)c4)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094450 IC50 586.0 nM
COc1ccc2[nH]cc(-c3cc4cnccc4cc3NC(C)=O)c2c1 CHEMBL3885335 IC50 590.0 nM
Cc1ccc(CNC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)cc1C CHEMBL5413503 IC50 595.0 nM
Clc1ccc(CNc2nccc(-c3ccc4cn[nH]c4c3)n2)cc1Cl CHEMBL2392367 IC50 599.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)c([N+](=O)[O-])c4)c3c2s1 CHEMBL3900000 IC50 599.8 nM
O=C1N=C(Nc2ccccc2)S/C1=C\c1ccc2c(c1)OCO2 CHEMBL5169780 IC50 610.0 nM
COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CCN)C4CCCCC4)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094459 IC50 615.0 nM
Brc1cnc2[nH]nc(-c3ccc4cc[nH]c4c3)c2c1 CHEMBL4847864 IC50 615.0 nM
CCCSC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1C CHEMBL5194491 IC50 620.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3c(cnn3C)c2)C(=O)N1C CHEMBL5414086 IC50 623.5 nM
O=C1NC(NCc2ccccc2OC(F)(F)F)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5431414 IC50 630.0 nM
CCN(CC)CCNC(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)c1 CHEMBL1970290 pKi 630.96 nM
Cc1ccnc2[nH]c3cc(C(C)C)ccc3c(=O)c12 CHEMBL1989471 pKi 630.96 nM
COCOc1cccc(OCOC)c1-c1ccc(NS(C)(=O)=O)cc1C(=O)OC CHEMBL2004025 pKi 630.96 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCCCCCCCCN)cnc(N)c34)cc2)c1 CHEMBL1978166 pKi 630.96 nM
CC(=O)n1ncc2cc(N)ccc21 CHEMBL1972454 pKi 630.96 nM
NC(=O)c1cc2c(-c3ccc(Nc4nc5ccccc5o4)cc3)cnc(N)c2s1 CHEMBL1993904 pKi 630.96 nM
O=C(Nc1cnccn1)Nc1cccc2c(O)cccc12 CHEMBL1992371 pKi 630.96 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 630.96 nM
Nc1cccc(-c2n[nH]c3ncc(Br)cc23)c1 CHEMBL4869480 IC50 635.0 nM
NC(=O)c1cc2c(-c3ccc(C(=O)NCc4ccnc(Cl)c4)s3)cccc2s1 CHEMBL5074567 Ki 642.3 nM
O=C1NC(NC2CCNCC2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5193677 IC50 650.0 nM
COC[C@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5403642 IC50 657.0 nM
NC(=O)c1cc2c(-c3ccc(C(=O)NCc4cccc(N)c4)s3)cccc2s1 CHEMBL5191496 Ki 659.7 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1C1CC1 CHEMBL5406672 IC50 662.7 nM
CN1CCC(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CC1 CHEMBL5415615 IC50 667.0 nM
NC(=O)c1cc2c(-c3ccc(C(=O)NC4CC4)s3)cccc2s1 CHEMBL5203368 Ki 669.7 nM
O/N=C/c1cccc(-c2cnc3ccc(Cl)nn23)c1 CHEMBL4077159 IC50 680.0 nM
CN(C1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1)c1ccccc1 CHEMBL5182235 IC50 680.0 nM
C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(-c4ccc5ocnc5c4)cc3c21 CHEMBL4083249 IC50 690.0 nM
O=C(Nc1ccccc1)Nc1nc2ccc(O)cc2s1 CHEMBL4285513 IC50 710.0 nM
O=C(O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1 CHEMBL297453 IC50 713.6 nM
CC(=O)N1CCc2ccc(NC3=N/C(=C\c4ccc5ncsc5c4)C(=O)N3)cc21 CHEMBL5433644 IC50 720.0 nM
NC(=O)c1cc2c(-c3ccc(C(=O)N[C@H](CO)Cc4ccccc4)s3)cccc2s1 CHEMBL5173386 Ki 729.9 nM
Nc1nc(N)c2nc(-c3cccc(O)c3)c(-c3cccc(O)c3)nc2n1 CHEMBL230011 Kd 730.0 nM
c1nc(NCC2CCOC2)c2cc(-c3ccc4c(c3)OCO4)ccc2n1 CHEMBL1436585 IC50 734.0 nM
Brc1cnc2[nH]nc(-c3ccsc3)c2c1 CHEMBL4847507 IC50 736.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3nnsc3c2)C(=O)N1C CHEMBL5426876 IC50 751.0 nM
O=C1NC(N[C@H]2CCCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5398602 IC50 769.0 nM
COc1ncc2cc(C(=O)Nc3cc(C(=O)NCCCN)ccc3Cl)c(=O)[nH]c2n1 CHEMBL3094458 IC50 774.0 nM
CO[C@H]1CCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5396081 IC50 779.0 nM
Cn1ncc2cc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)ccc21 CHEMBL5416744 IC50 780.0 nM
CCOC(=O)Cc1nc2c3cc(Br)ccc3[nH]c(=O)n2n1 CHEMBL1974480 pKi 794.33 nM
COc1cccc(OC)c1CNc1nc(NC2CCCCC2)nc2ccc(Cl)cc12 CHEMBL1996646 pKi 794.33 nM
N#CCC(C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL2002099 pKi 794.33 nM
Cc1ccc(-c2cc(-c3cc(Br)ccc3O)[nH]c(=O)c2C#N)s1 CHEMBL1997193 pKi 794.33 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 794.33 nM
Cc1cc(-c2ncnc3[nH]ccc23)ccc1F CHEMBL1997041 pKi 794.33 nM
O=C(Cc1cccs1)Nc1nc2ccccc2s1 CHEMBL1421720 pKi 794.33 nM
COc1ccccc1-c1ccnc(Nc2cccc(S(C)(=O)=O)c2)n1 CHEMBL1975903 pKi 794.33 nM
COc1cccc(Nc2ncnc3ccccc23)c1 CHEMBL117697 pKi 794.33 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 pKi 794.33 nM
CN(C)CC1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 CHEMBL360847 pKi 794.33 nM
C=CCc1cccc2c(=NO)cc(-c3ccccc3)oc12 CHEMBL1977749 pKi 794.33 nM
O=C(Nc1cnccn1)Nc1ccnc2ccc(N3CC4COCC4C3)cc12 CHEMBL2002599 pKi 794.33 nM
CCN(CCN)C(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)c1 CHEMBL2004637 pKi 794.33 nM
O=C(Nc1nc2ccccc2s1)c1cccc2c1CN(c1nc(C(=O)O)c(-c3ccc(CO)cc3)s1)CC2 CHEMBL1983980 pKi 794.33 nM
CC(=O)c1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL2000568 pKi 794.33 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 794.33 nM
O=C(c1ccc(O)cc1)c1cc2cc(O)ccc2s1 CHEMBL3335354 IC50 800.0 nM
NC(=O)c1cc2c(-c3cc(N)c(C(=O)NC4CC4)s3)cccc2s1 CHEMBL5173510 Ki 813.6 nM
FC(F)(F)c1cccc(-c2cnc3ccc(Cl)nn23)c1 CHEMBL4070065 IC50 820.0 nM
c1cncc(CNc2ccnc(-c3ccc4cn[nH]c4c3)n2)c1 CHEMBL1872011 IC50 829.0 nM
Cc1ccc(CNc2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)o1 CHEMBL1473127 IC50 846.0 nM
c1nc(NCC2CCCOC2)c2cc(-c3ccc4c(c3)OCO4)ccc2n1 CHEMBL1734733 IC50 856.0 nM
COc1ccc(-c2ccnc(NCc3ccc(Cl)cc3)n2)cc1 CHEMBL2392359 IC50 871.0 nM
Clc1ccc(Nc2nccc(-c3ccc4c(c3)OCO4)n2)cc1 CHEMBL1899640 IC50 884.0 nM
O=C1NC(=S)N/C1=C\c1ccc2ncsc2c1 CHEMBL3775754 IC50 900.0 nM
COc1ccc2c(c1)[nH]c1c3ccncc3cc(CNC(C)=O)c21 CHEMBL3885360 IC50 900.0 nM
CO[C@H]1Cc2ccccc2[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5399810 IC50 903.0 nM
COc1ccc2c(c1)[nH]c1c3ccncc3cc(CN)c21 CHEMBL3885328 IC50 910.0 nM
CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]nc(c3c2)-c2cn(nc2C(F)(F)F)CCCC1=O CHEMBL5089643 IC50 929.0 nM
c1nc(NCc2ccoc2)c2cc(-c3ccc4c(c3)OCO4)ccc2n1 CHEMBL566900 IC50 938.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 940.0 nM
O=C1NC(Nc2ccc(N3CCNCC3)cc2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5202202 IC50 950.0 nM
Cn1cc(-c2ccc3occ(-c4cccc(-c5ccncc5)c4)c3n2)cn1 CHEMBL4754195 IC50 956.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3ccc4[nH]ccc4c3)n2n1 CHEMBL4090770 IC50 960.0 nM
CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3c(cc2OC)CCN3C(=O)CN(C)C)nc2[nH]ccc12 CHEMBL464552 Kd 970.0 nM
CCSC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1C CHEMBL5187895 IC50 980.0 nM
NC(=O)c1cc2c(-c3ccc(C(=O)NCC4CC4)s3)cccc2s1 CHEMBL5202356 Ki 980.2 nM