O=C(c1ccc(Nc2ncc(F)c(-c3ccc4scnc4c3)n2)nc1)N1CCNCC1 CHEMBL5289179 IC50 0.6 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C1CCCC1 CHEMBL5084504 IC50 1.0 nM
Cc1nc(OCc2cncs2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5090676 IC50 2.0 nM
CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 CHEMBL4784318 IC50 2.0 nM
COc1cc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)c(OC)c2)ccc1O CHEMBL140 IC50 2.5 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C1CC1 CHEMBL4460561 IC50 3.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4F)c3c2s1 CHEMBL3894571 IC50 3.16 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CC(F)F CHEMBL5077927 IC50 4.0 nM
O=C(c1ccc(Nc2ncc(F)c(-c3ccc4scnc4c3)n2)cn1)N1CCNCC1 CHEMBL5286478 IC50 4.0 nM
COCCCn1c(C)nc2ccc(-c3cc(N)nc(N)c3)nc21 CHEMBL5089294 IC50 5.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C(C)(C)C CHEMBL5094409 IC50 6.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CCc1ccco1 CHEMBL5073976 IC50 6.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CC(F)(F)F CHEMBL5070553 IC50 6.0 nM
Cc1nc(OCc2ccsc2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5091510 IC50 8.0 nM
CN1CCN(c2ccc(NC3=N/C(=C\C4=COc5ccccc5O4)C(=O)N3)cc2)CC1 CHEMBL5195216 IC50 8.0 nM
CN1CCN(c2ccc(NC3=N/C(=C\c4ccc5c(c4)OCCO5)C(=O)N3)cc2)CC1 CHEMBL5414801 IC50 8.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CCC1CCCCC1 CHEMBL5072926 IC50 9.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CCOc1ccccc1 CHEMBL5088511 IC50 9.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CCCC(F)(F)F CHEMBL5080497 IC50 10.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C(C)C CHEMBL4441878 IC50 10.0 nM
O=C1NC(NC23CC4(F)CC(F)(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5422486 IC50 10.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1 CHEMBL2386747 IC50 10.8 nM
O=C1NC(Nc2ccc(O)c(F)c2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5181008 IC50 11.0 nM
O=C1NC(Nc2ccc(O)cc2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL1803085 IC50 11.0 nM
O=C1NC(NC23CC4CC(CC(O)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5405059 IC50 11.0 nM
COc1ccc2nc3ccc(OC)cc3c(SCCCN)c2c1 CHEMBL5095897 IC50 13.0 nM
O=C1NC(NC23CC4CC(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5438158 IC50 13.0 nM
Cc1nc(NCc2cccs2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5082044 IC50 14.0 nM
Cc1nc(NCc2ccsc2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5083159 IC50 14.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL1802358 IC50 14.0 nM
CCN(CC)c1nc2ccc(-c3nc(Nc4ccc(C(=O)N5CCN(C(=O)C6CC6)CC5)cn4)ncc3F)cc2s1 CHEMBL5419098 IC50 14.0 nM
COc1cc(/C=C2\N=C(Nc3ccc(N4CCN(C)CC4)cc3)NC2=O)ccc1O CHEMBL5200518 IC50 15.0 nM
CCN1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4ccc5scnc5c4)n3)cn2)CC1 CHEMBL5272300 IC50 15.0 nM
COc1ccc(/C=C2\N=C(Nc3ccc(N4CCN(C)CC4)cc3)NC2=O)cc1O CHEMBL5416942 IC50 15.0 nM
CCN(CC)c1nc2ccc(-c3nc(Nc4ccc(C(=O)N5CCN(C(C)=O)CC5)cn4)ncc3F)cc2s1 CHEMBL5395194 IC50 15.0 nM
O=C1N=C(Nc2c(Cl)cccc2Cl)S/C1=C\c1ccc2nccnc2c1 CHEMBL5081787 IC50 15.6 nM
O=C(O)c1nc2ccccc2c2[nH]c3c(Br)cccc3c12 CHEMBL3589661 IC50 16.0 nM
CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4ccc5scnc5c4)n3)cn2)CC1 CHEMBL5278493 IC50 16.0 nM
COC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5417147 IC50 16.0 nM
O=C1NC(NC[C@@H](O)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5428132 IC50 16.0 nM
Cc1nc(NCc2c(F)cccc2F)c2c(-c3ccnc(N)n3)c[nH]c2n1 CHEMBL5073598 IC50 20.0 nM
Cc1nc(NCc2ncccc2F)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5088687 IC50 20.0 nM
Cc1oc2ccc(-c3cc(N)nc(N)c3)cc2c1C CHEMBL5073869 IC50 21.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 22.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C[C@H](C)Oc1ccccc1 CHEMBL5071425 IC50 22.0 nM
Cc1ccc(C)c(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)c1 CHEMBL5179457 IC50 22.0 nM
CCN1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4ccc5scnc5c4)n3)nc2)CC1 CHEMBL5277818 IC50 22.0 nM
COc1ccc2c(c1)nc(C(=O)O)c1c3cccc(Br)c3[nH]c21 CHEMBL3589666 IC50 23.0 nM
O=C1NC(Nc2cccc(F)c2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5196066 IC50 23.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 CHEMBL3301610 IC50 25.4 nM
CNCc1ccc(-c2cc(-c3nc(-c4ccc(S(=O)(=O)C(C)C)cc4)cnc3N)on2)cc1 CHEMBL3989870 Ki 26.0 nM
CC(=O)N1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4ccc5ncsc5c4)n3)nc2)CC1 CHEMBL5404150 IC50 26.0 nM
COC1=CC2C(=O)NC3=Cc4ccc(OC)cc4C(=C1OC)C32 CHEMBL5279705 IC50 26.8 nM
CC(=O)N1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4ccc5scnc5c4)n3)nc2)CC1 CHEMBL5271186 IC50 28.0 nM
O=C1NC(NC23CC4CC(CC2C4)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5400230 IC50 28.0 nM
CCOC(=O)N1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4ccc5scnc5c4)n3)nc2)CC1 CHEMBL5289131 IC50 29.0 nM
CC(=O)N1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4ccc5nc(C)sc5c4)n3)nc2)CC1 CHEMBL5405426 IC50 30.0 nM
O=C(c1ccc(Nc2ncc(F)c(-c3ccc4ncsc4c3)n2)nc1)N1CCNCC1 CHEMBL5402420 IC50 31.0 nM
CCSC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL5181355 IC50 32.0 nM
NC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL5203292 IC50 32.0 nM
Oc1ccc(-c2n[nH]c3ncc(-c4ccc(O)c(O)c4)cc23)cc1 CHEMBL4873449 IC50 32.9 nM
COc1ccc2c(c1)nc(C(=O)O)c1c3cccc(Cl)c3[nH]c21 CHEMBL3589665 IC50 33.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CCOc1cccc(Cl)n1 CHEMBL5093661 IC50 33.0 nM
COc1cc(/C=C2\N=C(Nc3ccccc3)NC2=O)ccc1O CHEMBL5195122 IC50 33.0 nM
O=C1NC(Nc2ccccn2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5206744 IC50 33.0 nM
O=C(c1ccc(Nc2ncc(F)c(-c3ccc4scnc4c3)n2)nc1)N1CCN(C(=O)C2CC2)CC1 CHEMBL5277043 IC50 33.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CCOc1ccccn1 CHEMBL5077422 IC50 34.0 nM
Cc1ccc(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)cc1 CHEMBL1803084 IC50 34.0 nM
[2H]C1([2H])Oc2ccc(/C=C3\N=C(Nc4ccccc4)NC3=O)cc2O1 CHEMBL5199422 IC50 35.0 nM
O=C1NC(Nc2ccc(F)cc2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5180765 IC50 35.0 nM
CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4ccc5ncsc5c4)n3)nc2)CC1 CHEMBL5419711 IC50 35.0 nM
CCCSC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL5206143 IC50 37.0 nM
Cn1cc(-c2ccc3cnc(NC(=O)C4CCN(S(C)(=O)=O)CC4)cc3c2)cn1 CHEMBL5285332 IC50 37.2 nM
CCN(CC)c1nc2ccc(-c3nc(Nc4ccc(C(=O)N5CCNCC5)cn4)ncc3F)cc2s1 CHEMBL5402418 IC50 39.0 nM
O=C1NC(Nc2ccc3c(c2)OCO3)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL1802356 IC50 40.0 nM
O=C(O)c1nc2ccccc2c2[nH]c3c(Cl)cccc3c12 CHEMBL3589660 IC50 40.0 nM
c1cncc(-c2csc(-c3cncs3)c2)c1 CHEMBL3597991 IC50 40.0 nM
CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1N(C)CCN CHEMBL3103192 IC50 40.0 nM
CC(=O)Nc1cccc(Nc2ccc3ncc(-c4cccc(NC(C)=O)c4)n3n2)c1 CHEMBL4102871 IC50 40.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5091238 IC50 40.0 nM
O=C(c1ccc(Nc2ncc(F)c(-c3ccc4ncsc4c3)n2)nc1)N1CCN(C(=O)C2CC2)CC1 CHEMBL5411017 IC50 40.0 nM
COc1ccc2nc3c(CO)cc(OC)cc3c(SC[C@H]3CCNC3)c2c1 CHEMBL5286716 IC50 40.3 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2c(c1)CCO2 CHEMBL5208980 IC50 41.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(NC(C)=O)c3)n2n1 CHEMBL4061526 IC50 43.0 nM
CC(C)N1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4ccc5ncsc5c4)n3)nc2)CC1 CHEMBL5402534 IC50 44.0 nM
CCOc1cc(/C=C2\SC(=S)NC2=O)ccc1O CHEMBL5188976 IC50 45.6 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C[C@@H](C)Oc1ccccc1 CHEMBL4575900 IC50 46.0 nM
O=C1NC(NCC2CC2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL1803083 IC50 47.0 nM
CCOC(=O)c1cccc(-c2cnc3ccc(N[C@@H](CC)CO)nn23)c1 CHEMBL4071322 IC50 48.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 CHEMBL4105084 IC50 50.0 nM
CN1CCN(c2ccc(NC3=N/C(=C\c4ccc5c(c4)OCO5)C(=O)N3)cc2)CC1 CHEMBL5179655 IC50 50.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2[nH]cnc2c1 CHEMBL5404416 IC50 51.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CCOc1cccc(Br)n1 CHEMBL5089171 IC50 52.0 nM
Cc1ccc(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)cc1C CHEMBL5172170 IC50 55.0 nM
O=C(c1ccc(Nc2ncc(F)c(-c3ccc4scnc4c3)n2)nc1)N1CCN(c2ccccc2)CC1 CHEMBL5280825 IC50 56.0 nM
O=C1NC(NC2CCCCC(F)(F)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5396550 IC50 58.0 nM
CC(C)N1CCN(C(=O)c2ccc(Nc3nccc(-c4ccc5ncsc5c4)n3)nc2)CC1 CHEMBL5408179 IC50 58.0 nM
Cc1nc2ccc(-c3nc(Nc4ccc(C(=O)N5CCN(C(=O)C6CC6)CC5)cn4)ncc3F)cc2s1 CHEMBL5422059 IC50 58.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 59.0 nM
O=C1NC(=S)S/C1=C\c1ccc2ncccc2c1 CHEMBL3774448 IC50 60.0 nM
O=C1OCC/C1=C\c1ccc2ncsc2c1 CHEMBL3774704 IC50 60.0 nM
COc1nc(C)nc2[nH]cc(-c3ccnc(N)c3)c12 CHEMBL5081341 IC50 60.0 nM
CC(=O)NC12CC3CC(C1)CC(NC1=N/C(=C\c4ccc5ncsc5c4)C(=O)N1)(C3)C2 CHEMBL5422654 IC50 61.0 nM
CNCC(NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5439276 IC50 61.0 nM
CN1CCN(c2ccc(NC3=N/C(=C\c4ccc5ncsc5c4)C(=O)N3)cc2)CC1 CHEMBL5397343 IC50 61.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2ncoc2c1 CHEMBL5438293 IC50 62.0 nM
O=C1NC(NC23CC4CC(CC(NC(=O)C5CC5)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5418722 IC50 62.0 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 Kd 63.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(C=O)c3)n2n1 CHEMBL4093104 IC50 63.0 nM
CCN1CCN(C(=O)c2ccc(Nc3nccc(-c4ccc5scnc5c4)n3)nc2)CC1 CHEMBL5286238 IC50 67.0 nM
CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4ccc5scnc5c4)n3)nc2)CC1 CHEMBL5272422 IC50 70.0 nM
Cc1ccc(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)c(C)c1 CHEMBL5170033 IC50 75.0 nM
CS(=O)(=O)NC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5409574 IC50 76.0 nM
COc1cccc(-c2ccc3nc(C(=O)O)c4c5cccc(Cl)c5[nH]c4c3c2)c1 CHEMBL3589674 IC50 79.0 nM
COc1ccc(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)cc1 CHEMBL1802355 IC50 80.0 nM
Cc1nc(NCc2c(F)cccc2F)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5093650 IC50 80.0 nM
CN1C(=O)/C(=C/c2ccc3c(c2)OCO3)N=C1Nc1ccccc1 CHEMBL1803069 IC50 80.0 nM
CSC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL5187753 IC50 80.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(S(C)(=O)=O)c3)n2n1 CHEMBL4070189 IC50 82.0 nM
CCN1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4ccc5nc(NC6CCCC6)sc5c4)n3)nc2)CC1 CHEMBL5408961 IC50 84.0 nM
CC(=O)N1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4ccc5nc(NC6CCCC6)sc5c4)n3)nc2)CC1 CHEMBL5422366 IC50 85.0 nM
CN(C)C12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5412565 IC50 90.0 nM
O=C1NC(NC2CCCCC2(F)F)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5396991 IC50 91.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2c(c1)OCCO2 CHEMBL5194689 IC50 92.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5426285 IC50 93.0 nM
CCCNC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1C CHEMBL1802843 IC50 95.0 nM
Cn1cnc2ccc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)cc21 CHEMBL5420645 IC50 95.0 nM
NCC(NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5438728 IC50 96.0 nM
CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(Nc3nccc(-c4ccc5scnc5c4)n3)nc2)CC1 CHEMBL5273713 IC50 99.0 nM
O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 CHEMBL1230165 IC50 99.2 nM
CN1C(=O)/C(=C/c2ccc3c(c2)OCO3)N=C1Nc1ccc2c(c1)OCO2 CHEMBL1803072 IC50 100.0 nM
O=C1NC(=O)/C(=C/c2ccc3nccnc3c2)S1 CHEMBL568150 IC50 100.0 nM
CCCNC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL1803079 IC50 100.0 nM
CC(C)N1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4ccc5nc(NC6CCCC6)sc5c4)n3)nc2)CC1 CHEMBL5395374 IC50 106.0 nM
NC[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5441121 IC50 109.0 nM
O=C1NC(N[C@H]2CCCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5413726 IC50 109.0 nM
O=C1NC(Nc2ccc3c(c2)OCCO3)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL1802357 IC50 110.0 nM
CC(=O)Nc1cccc(Nc2ccc3ncc(-c4cccc(Cl)c4)n3n2)c1 CHEMBL4074499 IC50 110.0 nM
CO[C@@H]1CCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5440139 IC50 110.0 nM
CO[C@@H]1CCCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5440511 IC50 111.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 112.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C[C@@H](C)Oc1ccccn1 CHEMBL5092833 IC50 116.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C[C@H](C)Oc1ccccn1 CHEMBL5079873 IC50 117.0 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnc2ccc(Br)cn12 CHEMBL393525 IC50 117.6 nM
CN1C(=O)/C(=C/c2ccc3c(c2)OCO3)N=C1Nc1ccc2c(c1)OCCO2 CHEMBL1803073 IC50 120.0 nM
COc1ccc2c(c1)[nH]c1c(C)nccc12 CHEMBL269538 IC50 120.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(SC)c3)n2n1 CHEMBL4089652 IC50 120.0 nM
CC[C@@H](CO)N(C(C)=O)c1ccc2ncc(-c3cccc(NC(C)=O)c3)n2n1 CHEMBL4092673 IC50 120.0 nM
CC(C)c1cnn2c(NCc3ccc(-c4ccccn4)cc3)nc(N[C@H]3CC[C@H](N)CC3)nc12 CHEMBL4284209 IC50 120.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2c(c1)CCCO2 CHEMBL5207974 IC50 120.0 nM
O=C1NC(NC2CCCSC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5405233 IC50 124.0 nM
CC(C)C[C@H](COC1CC1)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5396386 IC50 125.0 nM
O=C(c1ccc(Nc2ncc(F)c(-c3ccc4nc(NC5CCCC5)sc4c3)n2)nc1)N1CCN(C(=O)C2CC2)CC1 CHEMBL5422765 IC50 128.0 nM
O=C1Nc2c(Br)cccc2/C1=C1/Nc2ccc(C(=O)O)cc2/C1=N\O CHEMBL1233659 IC50 130.0 nM
NCCOCCOCCOCCOc1ccc(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)cc1 CHEMBL3092863 IC50 130.0 nM
O=C(O)c1nc2ccc(I)cc2c2[nH]c3c(Br)cccc3c12 CHEMBL3589672 IC50 130.0 nM
CNC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL5200677 IC50 130.0 nM
O=C(O)c1ccc2c(c1)/C(=N\O)C(C1C(=O)Nc3c(Br)cccc31)N2 CHEMBL5272161 IC50 130.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1Cc1ccc(F)cc1 CHEMBL5073581 IC50 134.0 nM
CCN(CC)c1nc2ccc(-c3nc(Nc4ccc(N5CCNCC5)cn4)ncc3F)cc2s1 CHEMBL5413537 IC50 134.0 nM
CO[C@@H]1CCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5408907 IC50 135.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1C CHEMBL5085086 IC50 138.3 nM
CCOC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5409730 IC50 145.0 nM
CC(=O)OC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5412101 IC50 145.0 nM
O=C(c1ccc(Nc2ncc(F)c(-c3ccc4nc(NC5CCCC5)sc4c3)n2)nc1)N1CCNCC1 CHEMBL5405837 IC50 145.0 nM
CC(C)(C)NC(=O)OC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5421442 IC50 147.0 nM
Cc1nc2ccc(-c3nc(Nc4ccc(C(=O)N5CCN(C(C)C)CC5)cn4)ncc3F)cc2s1 CHEMBL5408710 IC50 147.0 nM
NCCOCCOCCOc1ccc(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)cc1 CHEMBL3092862 IC50 150.0 nM
Cc1nc(NCc2ccccc2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5092157 IC50 150.0 nM
COC[C@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5439392 IC50 159.0 nM
CCNC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL1803082 IC50 160.0 nM
CO[C@H]1CCCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5422857 IC50 162.0 nM
O=C1NC(Nc2nncs2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5424295 IC50 164.0 nM
CCN1C(=O)/C(=C/c2ccc3ncsc3c2)N=C1N[C@@H](COC)CC(C)C CHEMBL5433334 IC50 165.1 nM
Oc1ccc(-c2cnc3[nH]cc(-c4ccc(O)cc4)c3c2)cc1 CHEMBL3102950 IC50 166.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1C1CC1 CHEMBL5406672 IC50 168.5 nM
COc1ccc2ncc(-c3cccc(/C=N/O)c3)n2n1 CHEMBL4072506 IC50 170.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5418020 IC50 170.0 nM
O=C1NC(N[C@@H]2CCCC[C@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5401675 IC50 174.0 nM
CN1CCN(c2ncc(NC3=N/C(=C\c4ccc5ncsc5c4)C(=O)N3)cn2)CC1 CHEMBL5407057 IC50 175.0 nM
CC1(C)C2CCC1(C)[C@H](NC1=N/C(=C\c3ccc4ncsc4c3)C(=O)N1)C2 CHEMBL5412900 IC50 176.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(C(F)(F)F)c3)n2n1 CHEMBL4086402 IC50 180.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5420724 IC50 183.0 nM
CC1(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CCNC1=O CHEMBL5423406 IC50 189.0 nM
CC(C)[C@@H](CO)Nc1ccc2ncc(-c3cccnc3)n2n1 CHEMBL4074132 IC50 190.0 nM
O=C(c1ccc(Nc2nccc(-c3ccc4scnc4c3)n2)nc1)N1CCNCC1 CHEMBL5280350 IC50 190.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C[C@@H](C)Oc1cccc(Br)n1 CHEMBL5084166 IC50 195.0 nM
O=C1NC(=S)S/C1=C\c1ccc2ncsc2c1 CHEMBL3775393 IC50 200.0 nM
Cc1nc2ccc(-c3nc(Nc4ccc(CN5CCN(C(C)C)CC5)cn4)ncc3F)cc2s1 CHEMBL5429972 IC50 203.0 nM
Cn1cc2cc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)ccc2n1 CHEMBL5408531 IC50 207.0 nM
CC(C)CNC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1C CHEMBL1802846 IC50 210.0 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 210.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cc4ccccc4[nH]3)n2n1 CHEMBL4062820 IC50 210.0 nM
Cc1nc(NCc2ccoc2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5092828 IC50 210.0 nM
CC(C)CN1CCC(C(=O)Nc2cc3cc(-c4cnn(C)c4)ccc3cn2)CC1 CHEMBL5289681 IC50 215.0 nM
Fc1cnc(Nc2ccc(CN3CCNCC3)cn2)nc1-c1ccc2scnc2c1 CHEMBL5279010 IC50 216.0 nM
COC(=O)[C@H](Cc1ccccc1)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5434955 IC50 216.0 nM
CN1C(=O)/C(=C2\Nc3ccc(C(=O)O)cc3\C2=N/O)c2cccc(Br)c21 CHEMBL2321958 IC50 220.0 nM
O=C(O)c1nc2ccc(I)cc2c2[nH]c3c(Cl)cccc3c12 CHEMBL3589671 IC50 220.0 nM
COc1ccc(/C=C2\N=C(Nc3ccccc3)NC2=O)cc1 CHEMBL5205157 IC50 220.0 nM
O=C1NC(N2CCCCC2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5201763 IC50 220.0 nM
CCN1/C(=C/C(C)=O)Sc2ccc(O)cc21 CHEMBL1232500 IC50 225.8 nM
O=C1NC(Nc2ccc(N3CCCCC3)cc2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5193292 IC50 230.0 nM
O=C1NC(N[C@H]2CCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5424363 IC50 231.0 nM
CO[C@@H]1Cc2ccccc2[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5414635 IC50 235.0 nM
O=C1NC(N[C@@H]2CCCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5427523 IC50 237.0 nM
O=C1NC(NC2COCCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5421636 IC50 237.0 nM
O=C1NC(NC2CC3CCC2C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5412998 IC50 240.0 nM
Cc1nc2ccc(-c3nc(Nc4ccc(CN5CCNCC5)cn4)ncc3F)cc2s1 CHEMBL5399259 IC50 242.0 nM
O=C1NC(N[C@H](CO)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429783 IC50 249.0 nM
O=C1NC(NC2CCNCC2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5193677 IC50 250.0 nM
O=C1NC(Nc2ccccn2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5417527 IC50 256.0 nM
CC(=O)N1CCc2ccc(NC3=N/C(=C\c4ccc5ncsc5c4)C(=O)N3)cc21 CHEMBL5433644 IC50 257.0 nM
O=C1NC(N[C@@H]2CCC[C@@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5415622 IC50 258.0 nM
O=C1NC(N[C@@H]2CCCC[C@@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5437778 IC50 258.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2[nH]ncc2c1 CHEMBL5405572 IC50 260.0 nM
COC[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5401217 IC50 260.0 nM
CC1(C)CCC(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CO1 CHEMBL5436147 IC50 260.0 nM
CC(C)C[C@@H](CF)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5438412 IC50 263.0 nM
Cc1cnc(Nc2ccc(C(=O)N3CCN(C(=O)OC(C)(C)C)CC3)cn2)nc1-c1ccc2scnc2c1 CHEMBL5270999 IC50 268.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc(O)c(O)c1 CHEMBL5191942 IC50 270.0 nM
O=C1NC(N[C@@H](CO)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5404544 IC50 290.0 nM
O=C1NC(N[C@H]2C3CC4CC2C[C@](O)(C4)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5428651 IC50 296.0 nM
CO[C@H]1CCC[C@@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5427842 IC50 297.0 nM
N#C/C(=C1/Nc2ccccc2S1)c1ccnc(NCCc2cccnc2)n1 CHEMBL191384 IC50 300.0 nM
COc1nc(C)nc2[nH]cc(-c3ccnc(C)c3)c12 CHEMBL5092245 IC50 300.0 nM
COc1ccc2ncc(-c3ccc4[nH]ccc4c3)n2n1 CHEMBL4079347 IC50 320.0 nM
CN(C1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1)c1ccccc1 CHEMBL5182235 IC50 320.0 nM
COC(=O)[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)C(C)C CHEMBL5416274 IC50 328.0 nM
CCCSC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1C CHEMBL5194491 IC50 330.0 nM
CN1C(=O)/C(=C/c2ccc3c(c2)OCO3)N=C1NCC1CC1 CHEMBL1802849 IC50 340.0 nM
CCSC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1C CHEMBL5187895 IC50 340.0 nM
CO[C@@H]1CCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5394394 IC50 342.0 nM
O=C1Nc2ccccc2/C1=C1/Nc2ccc(C(=O)O)cc2/C1=N\O CHEMBL2321952 IC50 350.0 nM
O=C1NC(Nc2ccc(N3CCNCC3)cc2)=N/C1=C\c1ccc2c(c1)OC=CO2 CHEMBL5173265 IC50 350.0 nM
COC(CNC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5424074 IC50 352.0 nM
O=C1NC(NC2CC23CCCCC3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5434921 IC50 355.0 nM
Cc1cnc(Nc2ccc(C(=O)N3CCNCC3)cn2)nc1-c1ccc2scnc2c1 CHEMBL5278425 IC50 357.0 nM
CN(C)c1nccc(-c2cnn3ncccc23)n1 CHEMBL4848254 Kd 360.0 nM
Cn1ncc2cc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)ccc21 CHEMBL5416744 IC50 363.0 nM
O=C1NC(N[C@H]2CCC[C@H](O)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5438325 IC50 377.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3ccc4[nH]ccc4c3)n2n1 CHEMBL4090770 IC50 380.0 nM
CC[C@H](CO)/N=C/c1cccc(-c2cnc3ccc(N[C@H](CC)CO)nn23)c1 CHEMBL4084919 IC50 380.0 nM
CO[C@@H]1CCCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5428629 IC50 387.0 nM
O=C1NC(NC2CCC(F)(F)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5427398 IC50 389.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 390.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(/C=N/O)c3)n2n1 CHEMBL4065432 IC50 390.0 nM
O=C1NC(N[C@@H]2c3ccccc3C[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5398161 IC50 390.0 nM
O=C1NC(NC2CCCC(F)(F)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5411888 IC50 391.0 nM
O=C1NC(N[C@@H]2CCC[C@H](O)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5403037 IC50 395.0 nM
O=C1NC(NC2CCCCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430192 IC50 399.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3ccnc(N)n3)n2n1 CHEMBL4084364 IC50 400.0 nM
Cc1nc(OCc2cc(C)on2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5090159 IC50 400.0 nM
Cc1nc(OCc2ccccc2)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5081888 IC50 400.0 nM
COCC(Cc1ccccc1)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5406461 IC50 400.0 nM
Oc1ccc(-c2c[nH]c3ncc(-c4ccc(-c5nnn[nH]5)cc4)cc23)cc1 CHEMBL4087125 IC50 408.0 nM
O=C1NC(N2CCOCC2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5207630 IC50 410.0 nM
COc1cc(/C=C2\N=C(Nc3ccc(N4CCCCC4)cc3)NC2=O)ccc1O CHEMBL5181028 IC50 410.0 nM
O=C1NC(Nc2ccc(N3CCNCC3)cc2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5202202 IC50 410.0 nM
COC(=O)[C@H](C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5423907 IC50 413.0 nM
CO[C@H]1CCC[C@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CC1 CHEMBL5396280 IC50 415.0 nM
Oc1ccc(-c2cnc3[nH]cc(-c4ccc(-c5nnn[nH]5)cc4)c3c2)cc1 CHEMBL4102553 IC50 416.0 nM
O=C1NC(NC[C@H](O)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430262 IC50 417.0 nM
CO[C@H]1CCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5396081 IC50 422.0 nM
O=C1NC(NC2CCCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5283849 IC50 429.0 nM
CC1C/C(=C\c2ccc3c(c2)CCO3)C(=O)O1 CHEMBL3775111 IC50 430.0 nM
CN1C(=O)/C(=C/c2ccc3c(c2)OCO3)N=C1N CHEMBL485053 IC50 430.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4ccc5scnc5c4)n3)nc2)CC1 CHEMBL5281152 IC50 430.0 nM
CC(C)C[C@H](CF)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5426735 IC50 433.0 nM
O=C(Nc1ccc2[nH]ncc2c1)c1csc(Nc2ccccc2)n1 CHEMBL5284529 IC50 438.5 nM
OCCN1CCN(c2ccc3ncc(-c4cccc(Cl)c4)n3n2)CC1 CHEMBL4071013 IC50 440.0 nM
CSc1ccc2ncc(-c3ccc4[nH]ccc4c3)n2n1 CHEMBL4090223 IC50 440.0 nM
CCC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1C CHEMBL5283179 IC50 440.0 nM
O=C1NC(NC2CCC(F)(F)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5432739 IC50 455.0 nM
O=C1NC(N[C@@H]2CCC[C@@H](O)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5420497 IC50 458.0 nM
CO[C@H]1CCC[C@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5436754 IC50 469.0 nM
CN1C(=O)/C(=C/c2ccc3c(c2)OCO3)N=C1NCCCO CHEMBL1802853 IC50 470.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 470.0 nM
O=C1NC(N[C@@H]2CCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429789 IC50 472.0 nM
NC(=O)Nc1ccc(-c2cnc3[nH]cc(-c4ccc(O)cc4)c3c2)cc1 CHEMBL4067661 IC50 476.0 nM
Cc1nc(CN(C)c2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)cs1 CHEMBL1474834 Kd 480.0 nM
FC(F)(F)c1cccc(-c2cnc3ccc(Cl)nn23)c1 CHEMBL4070065 IC50 480.0 nM
CN1C(=O)/C(=C\c2ccc3c(c2)OCO3)N=C1N CHEMBL4291088 IC50 490.0 nM
CS(=O)(=O)N1CCN(Cc2ccc(Nc3ncc(F)c(-c4ccc5ncsc5c4)n3)nc2)CC1 CHEMBL5431455 IC50 494.0 nM
CCN1CCN(C(=O)c2ccc(Nc3ncc(C)c(-c4ccc5scnc5c4)n3)nc2)CC1 CHEMBL5279534 IC50 498.0 nM
O=C1NC(N[C@H]2CCCCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5423580 IC50 499.0 nM
CC[C@@H](CO)/N=C/c1cccc(-c2cnc3ccc(N[C@@H](CC)CO)nn23)c1 CHEMBL4070227 IC50 500.0 nM
NC[C@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5406081 IC50 507.0 nM
COc1ccc(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2C)cc1 CHEMBL1803071 IC50 510.0 nM
CCCCCOc1ccc(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)cc1 CHEMBL5209464 IC50 510.0 nM
COC(=O)[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)C(C)O CHEMBL5401116 IC50 513.0 nM
O=C1NC(N[C@H]2CCCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429703 IC50 516.0 nM
O=C1NC(NCC(O)Cc2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5398512 IC50 527.0 nM
CC(C)NC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1C CHEMBL1802844 IC50 530.0 nM
COCCN1CCC(CNC(=O)c2n[nH]c3ccc(-c4cccc(F)c4F)cc23)CC1 CHEMBL3735506 IC50 530.0 nM
O=C1NC(NC(CF)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5404644 IC50 530.0 nM
O=C1NC(N[C@@H]2COCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5431345 IC50 534.0 nM
CC(C)(C)OC(=O)N1CCN(C(=O)c2cnc(Nc3ncc(F)c(-c4ccc5scnc5c4)n3)nc2)CC1 CHEMBL5272665 IC50 535.0 nM
CC(=O)Nc1ccc(-c2cnc3[nH]cc(-c4ccc(O)cc4)c3c2)cc1 CHEMBL4078550 IC50 536.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4ccc5nc(NC6CCCC6)sc5c4)n3)nc2)CC1 CHEMBL5402306 IC50 545.0 nM
C[C@@H]1CCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5433142 IC50 549.0 nM
CCN(CC)c1nc2ccc(-c3nc(Nc4ccc(C(=O)N5CCN(C(=O)OC(C)(C)C)CC5)cn4)ncc3F)cc2s1 CHEMBL5398165 IC50 556.0 nM
O=C1NC(N[C@@H]2CCCCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5414514 IC50 559.0 nM
CC(C)CCNC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1C CHEMBL1802847 IC50 560.0 nM
CN1C(=O)/C(=C/c2ccc3c(c2)OCO3)N=C1NCc1ccccc1 CHEMBL1803067 IC50 560.0 nM
O=C1NC(NCc2ccccc2C(F)(F)F)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430415 IC50 560.0 nM
O=C1NC(NC2CCCCCC2)=N/C1=C\c1ccc2ncoc2c1 CHEMBL5430824 IC50 566.0 nM
Nc1ccc(-c2cnc3[nH]cc(-c4ccc(O)cc4)c3c2)cc1 CHEMBL4096575 IC50 567.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 IC50 570.0 nM
Oc1ccc(-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)cc1 CHEMBL4084605 IC50 571.0 nM
O=C1NC(N[C@@H]2CCC[C@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5393925 IC50 571.0 nM
O=C1NC(NC2C3CC4CC(C3)CC2C4)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5417207 IC50 573.0 nM
O=C1NC(NC2COC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5412372 IC50 574.0 nM
CO[C@H]1CCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CC1 CHEMBL5429272 IC50 579.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1C1CCC1 CHEMBL5430240 IC50 581.0 nM
O=C1NC(NCCCn2ccnc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5398474 IC50 592.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccnc3)n2n1 CHEMBL4100956 IC50 600.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3ccsc3)n2n1 CHEMBL4097368 IC50 600.0 nM
CCCCNC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1C CHEMBL1802845 IC50 610.0 nM
Clc1ccc2ncc(-c3ccc4[nH]ccc4c3)n2n1 CHEMBL4091942 IC50 610.0 nM
O=C1NC(NCc2ccncc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5434728 IC50 613.0 nM
O=C1NC(Nc2cncnc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5407276 IC50 617.0 nM
C=CCNC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1C CHEMBL1802848 IC50 620.0 nM
O=C1NC(N[C@H]2CC[C@H](O)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5422936 IC50 625.0 nM
O=C1NC(NC2CCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430357 IC50 627.0 nM
CC(C)C[C@H](CO)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5412105 IC50 635.0 nM
c1cc(-c2ccc3scnc3c2)nc(Nc2ccc(CN3CCNCC3)cn2)n1 CHEMBL5274593 IC50 636.0 nM
CCNC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1C CHEMBL1802842 IC50 640.0 nM
Oc1ccc(-c2c[nH]c3ncc(-c4ccc5[nH]ccc5c4)cc23)cc1 CHEMBL4065701 IC50 644.0 nM
O=C1NC(N[C@@H]2CCCCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5439952 IC50 644.0 nM
CC(C)N1CCN(Cc2ccc(Nc3ncc(F)c(-c4ccc5nc(NC6CCCC6)sc5c4)n3)nc2)CC1 CHEMBL5417533 IC50 647.0 nM
O=C1NC(N[C@H]2CN3CCC2CC3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5428107 IC50 662.0 nM
O=C1CC[C@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CN1 CHEMBL5433242 IC50 664.0 nM
Cc1nc2ccc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)cc2s1 CHEMBL5407040 IC50 666.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 680.0 nM
Fc1cnc(Nc2ccc(CN3CCNCC3)cn2)nc1-c1ccc2nc(NC3CCCC3)sc2c1 CHEMBL5414419 IC50 688.0 nM
C[C@@H]1[C@H]2C[C@@H](C[C@H]1NC1=N/C(=C\c3ccc4ncsc4c3)C(=O)N1)C2(C)C CHEMBL5416470 IC50 690.0 nM
O=C(c1cnc(Nc2ncc(F)c(-c3ccc4scnc4c3)n2)nc1)N1CCNCC1 CHEMBL5286408 IC50 695.0 nM
COC(=O)C1(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C2CC3CC(C2)CC1C3 CHEMBL5417890 IC50 702.0 nM
O=C1NC(NC2CCCCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5424272 IC50 704.0 nM
CN1C(=O)/C(=C/c2ccc3c(c2)OCO3)N=C1NCCN CHEMBL1179821 IC50 710.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C/c2ccc3ncsc3c2)C(=O)N1 CHEMBL5432405 IC50 711.6 nM
O=C1NC(Nc2cccnc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5427325 IC50 722.0 nM
CS(=O)(=O)Nc1ccc(-c2cnc3[nH]cc(-c4ccc(O)cc4)c3c2)cc1 CHEMBL4088888 IC50 724.0 nM
O/N=C/c1cccc(-c2cnc3ccc(Cl)nn23)c1 CHEMBL4077159 IC50 730.0 nM
Fc1cnc(Nc2ccc(N3CCNCC3)cn2)nc1-c1ccc2nc(NC3CCCC3)sc2c1 CHEMBL5411704 IC50 733.0 nM
O=C1NC(Nc2ccc(F)cc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5424064 IC50 743.0 nM
O=C1NC(Nc2cccc(OC(F)F)c2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5409693 IC50 760.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1nccc(-c2cn(C)c3cnccc23)n1 CHEMBL3421968 IC50 764.3 nM
COCCNC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1C CHEMBL1802852 IC50 770.0 nM
Cn1cc(-c2cccc(-c3coc4ccc(-c5cnn(C)c5)nc34)c2)cn1 CHEMBL4797457 IC50 771.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1C1CCCC1 CHEMBL5424188 IC50 773.7 nM
COc1cnc(Nc2ccc(C(=O)N3CCNCC3)cn2)nc1-c1ccc2scnc2c1 CHEMBL5289173 IC50 774.0 nM
CO[C@H]1CCCC[C@@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5413743 IC50 777.0 nM
COc1cnc(Nc2ccc(CN3CCNCC3)cn2)nc1-c1ccc2scnc2c1 CHEMBL5274485 IC50 779.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3ccc(C(F)(F)F)cc3)n2n1 CHEMBL4104296 IC50 780.0 nM
CN1CC[C@@](C)(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1=O CHEMBL5429707 IC50 795.0 nM
CN1CCN(c2cnc(NC3=N/C(=C\c4ccc5ncsc5c4)C(=O)N3)cn2)CC1 CHEMBL5426807 IC50 798.0 nM
O=C1NC(NCC2CCOCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5425492 IC50 811.0 nM
COc1ccc2c3ccnc(Cl)c3n(CC#N)c2c1 CHEMBL4283240 IC50 813.5 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4ccc5nc(C)sc5c4)n3)nc2)CC1 CHEMBL5437184 IC50 819.0 nM
O=C1OCC/C1=C\c1ccc2c(c1)CCO2 CHEMBL3775821 IC50 820.0 nM
O=Cc1cccc(-c2cnc3ccc(Cl)nn23)c1 CHEMBL4076448 IC50 820.0 nM
CO[C@H]1CCCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5411157 IC50 836.0 nM
O=C(Nc1cccc(O)c1)c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1 CHEMBL4105239 IC50 847.0 nM
CC1(C)CNC(=O)C1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5411344 IC50 854.0 nM
O=C1NC(NC2CCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5439694 IC50 868.0 nM
O=C1NC(N[C@@H](CO)Cc2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5435490 IC50 886.0 nM
COC(=O)[C@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5428794 IC50 903.0 nM
O=C1NC(N[C@@H]2CN3CCC2CC3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5434213 IC50 908.0 nM
O=C1NC(N2CCCC2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5175458 IC50 930.0 nM
CC(C)C[C@H](COCc1ccccc1)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5428588 IC50 946.0 nM
O=C(O)c1ccc2c3c1cccc3c(=O)n1c3ccccc3nc21 CHEMBL265470 IC50 950.0 nM
O=C1OCC/C1=C\c1ccc2c(c1)OCO2 CHEMBL3193172 IC50 990.0 nM
O=C1NC(=S)S/C1=C\c1ccc2c(c1)CCO2 CHEMBL3774830 IC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM