C[C@@H](Oc1cc(C(=O)N(C)C)ccc1Nc1nc(O[C@H]2CC[C@@](C)(O)CC2)c2c(Cl)c[nH]c2n1)C(F)(F)F CHEMBL4546504 IC50 0.104 nM
O=C1N/C(=N/c2ccccc2Br)S/C1=C\c1ccc2ncccc2c1 CHEMBL3728543 pIC50 1.0 nM
Nc1ccc(Cl)c(NC2=NC(=O)/C(=C/c3ccc4ncccc4c3)S2)c1 CHEMBL3728359 pIC50 1.0 nM
O=C1NC(NC23CC4(F)CC(F)(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5422486 IC50 2.0 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 5.012 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 5.012 nM
O=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21 CHEMBL1997129 pKi 7.943 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCCCC2)n1 CHEMBL2006439 pKi 7.943 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 7.943 nM
Cc1cccc(-c2[nH]c(-c3ccnc(N)n3)cc2C(N)=O)c1C CHEMBL1964290 pKi 10.0 nM
COc1cc(C=C2SC(=S)NC2=O)ccc1O CHEMBL1973098 pKi 10.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 10.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 10.0 nM
O=C1N/C(=N/c2ccccc2Cl)S/C1=C\c1ccc2ncccc2c1 CHEMBL3730504 pIC50 10.0 nM
COc1cc(/C=C2\N=C(Nc3ccc(N4CCN(C)CC4)cc3)NC2=O)ccc1O CHEMBL5200518 IC50 10.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2[nH]cnc2c1 CHEMBL5404416 IC50 10.0 nM
COc1ccc(/C=C2\N=C(Nc3ccc(N4CCN(C)CC4)cc3)NC2=O)cc1O CHEMBL5416942 IC50 10.0 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnc2ccc(Br)cn12 CHEMBL393525 IC50 10.4 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 11.4 nM
O=C1NC(NC23CC4CC(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5438158 IC50 12.0 nM
CN1CCN(c2ccc(NC3=N/C(=C\C4=COc5ccccc5O4)C(=O)N3)cc2)CC1 CHEMBL5195216 IC50 14.0 nM
O=C1NC(NC23CC4CC(CC(O)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5405059 IC50 14.0 nM
CN1CCN(c2ccc(NC3=N/C(=C\c4ccc5c(c4)OCCO5)C(=O)N3)cc2)CC1 CHEMBL5414801 IC50 14.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1F CHEMBL1981079 pKi 15.85 nM
CN(C)C12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5412565 IC50 16.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5091238 IC50 19.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 CHEMBL3301610 IC50 20.6 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4F)c3c2s1 CHEMBL3894571 IC50 21.1 nM
CC(=O)NC12CC3CC(C1)CC(NC1=N/C(=C\c4ccc5ncsc5c4)C(=O)N1)(C3)C2 CHEMBL5422654 IC50 22.0 nM
O=C1N=C(Nc2c(Cl)cccc2Cl)S/C1=C\c1ccc2nccnc2c1 CHEMBL5081787 IC50 22.7 nM
COC1=CC2C(=O)NC3=Cc4ccc(OC)cc4C(=C1OC)C32 CHEMBL5279705 IC50 23.5 nM
COC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5417147 IC50 24.0 nM
O=C1NC(NC23CC4CC(CC(NC(=O)C5CC5)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5418722 IC50 24.0 nM
CS(=O)(=O)NC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5409574 IC50 24.0 nM
CN1CCN(c2ccc(NC3=N/C(=C\c4ccc5c(c4)OCO5)C(=O)N3)cc2)CC1 CHEMBL5179655 IC50 25.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCCN)c3)cc12 CHEMBL1967887 pKi 25.12 nM
NC[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5441121 IC50 28.0 nM
COc1cccc(-c2ccc3nc(C(=O)O)c4c5cccc(Cl)c5[nH]c4c3c2)c1 CHEMBL3589674 IC50 30.0 nM
Cc1nc(NCc2ncccc2F)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5088687 IC50 30.0 nM
O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 CHEMBL1230165 IC50 30.8 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 31.62 nM
Cc1ccc(C(=O)Nc2ccon2)cc1Nc1ncnc2c1cnn2-c1ccccc1 CHEMBL259922 pKi 31.62 nM
O=C1NC(NC2CCCCC(F)(F)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5396550 IC50 35.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2ncoc2c1 CHEMBL5438293 IC50 38.0 nM
NCC(NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5438728 IC50 38.0 nM
CCCCNc1ccc2c3c(cccc13)C(=O)N(CCNCCO)C2=O CHEMBL1987359 pKi 39.81 nM
NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(-c3ccncc3)ccc2c1=O CHEMBL340384 pKi 39.81 nM
CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1N(C)CCN CHEMBL3103192 IC50 40.0 nM
Cn1cc2cc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)ccc2n1 CHEMBL5408531 IC50 40.0 nM
O=C1NC(NC23CC4CC(CC2C4)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5400230 IC50 42.0 nM
CNCC(NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5439276 IC50 45.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5420724 IC50 47.0 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL225519 pKi 50.12 nM
CC(C)Nc1c(-c2ccc3[nH]ncc3c2)nc2ncccn12 CHEMBL1682553 pKi 50.12 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 50.12 nM
CC(C)Nc1ccc2cnn(-c3cncc(-c4ccc(C(=O)O)cc4)n3)c2c1 CHEMBL4228654 IC50 54.0 nM
CN1CCN(c2ccc(NC3=N/C(=C\c4ccc5ncsc5c4)C(=O)N3)cc2)CC1 CHEMBL5397343 IC50 58.0 nM
CC(=O)OC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5412101 IC50 60.0 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 63.1 nM
Clc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 CHEMBL1969588 pKi 63.1 nM
Cn1cnc2ccc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)cc21 CHEMBL5420645 IC50 68.0 nM
CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1C CHEMBL2409175 IC50 70.0 nM
Oc1ccc(-c2n[nH]c3ncc(-c4ccc(O)c(O)c4)cc23)cc1 CHEMBL4873449 IC50 71.9 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2[nH]ncc2c1 CHEMBL5405572 IC50 74.0 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 79.43 nM
Cc1c[nH]c2nccc(Oc3c(F)cc(Nc4cc(Cl)nc(N)n4)cc3F)c12 CHEMBL1971943 pKi 79.43 nM
O=C(NNC(=S)Nc1ccc(Cl)cc1)C(O)(c1ccccc1)c1ccccc1 CHEMBL1966722 pKi 79.43 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4cnc5ccccc5c4)c3)cc21 CHEMBL226403 pKi 79.43 nM
O=C(Nc1cnccn1)Nc1ccnc2ccc(C(F)(F)F)cc12 CHEMBL1976455 pKi 79.43 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 CHEMBL4105084 IC50 81.0 nM
CCN1/C(=C/C(C)=O)Sc2ccc(O)cc21 CHEMBL1232500 IC50 82.6 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1 CHEMBL2386747 IC50 93.2 nM
CNC(=O)c1ccc(Nc2nc(OC3CCCC3)c3c(-c4ccc5nc(C)oc5c4)c[nH]c3n2)c(OC)c1 CHEMBL4062218 IC50 99.0 nM
COc1cc(C=C2SC(=O)NC2=O)ccc1O CHEMBL2003286 pKi 100.0 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 100.0 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 100.0 nM
Clc1cc(NC2CCCCC2)nc(-c2c[nH]c3ncccc23)n1 CHEMBL1997846 pKi 100.0 nM
O=C1N/C(=N/c2ccccc2C(F)(F)F)S/C1=C\c1ccc2c(c1)CCO2 CHEMBL3731253 pIC50 100.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(NC(C)=O)c3)n2n1 CHEMBL4061526 IC50 110.0 nM
CCOC(=O)c1cccc(-c2cnc3ccc(N[C@@H](CC)CO)nn23)c1 CHEMBL4071322 IC50 110.0 nM
COc1ccc2nc3c(CO)cc(OC)cc3c(SC[C@H]3CCNC3)c2c1 CHEMBL5286716 IC50 111.8 nM
CN1CCN(c2ncc(NC3=N/C(=C\c4ccc5ncsc5c4)C(=O)N3)cn2)CC1 CHEMBL5407057 IC50 112.0 nM
NC[C@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5406081 IC50 114.0 nM
O=C1NC(NC2CCCCC2(F)F)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5396991 IC50 119.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cc4ccccc4[nH]3)n2n1 CHEMBL4062820 IC50 120.0 nM
COc1cc(/C=C2\N=C(Nc3ccccc3)NC2=O)ccc1O CHEMBL5195122 IC50 120.0 nM
O=C1NC(N[C@H]2C3CC4CC2C[C@](O)(C4)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5428651 IC50 122.0 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 125.89 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)cncc21 CHEMBL1964692 pKi 125.89 nM
Cc1cc(Cl)ccc1NC(=S)NNC(=O)C(O)(c1ccccc1)c1ccccc1 CHEMBL1988173 pKi 125.89 nM
O=c1nc(-c2cc3c(Oc4ccc(I)cc4)cncc3s2)[nH]o1 CHEMBL497151 pKi 125.89 nM
COc1cc(C=C(C#N)c2nc3ccccc3[nH]2)c(Br)cc1O CHEMBL1994241 pKi 125.89 nM
Cc1ccc(Nc2nc3ccc([N+](=O)[O-])cc3[nH]2)nc1 CHEMBL1992937 pKi 125.89 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 CHEMBL2003638 pKi 125.89 nM
O=C1NC(NC2CCCCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430192 IC50 133.0 nM
CO[C@@H]1CCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5440139 IC50 135.0 nM
COc1ccc2ncc(-c3cccc(/C=N/O)c3)n2n1 CHEMBL4072506 IC50 140.0 nM
Cc1nc(NCc2c(F)cccc2F)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5093650 IC50 140.0 nM
O=C1NC(Nc2ccc(O)cc2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL1803085 IC50 140.0 nM
Cc1cc(O)ccc1-n1cc(C(=O)NN)c(=O)c2ccc(-c3ccncc3)cc21 CHEMBL2000894 pKi 158.49 nM
CC(N)COc1cnc(Cl)c(C=Cc2ccncc2)c1 CHEMBL1993548 pKi 158.49 nM
COc1ccc(C=C2SC(=Nc3ccccc3)NC2=O)cc1O CHEMBL2000354 pKi 158.49 nM
CS(=O)(=O)N(Cc1ccc2[nH]c(=O)c3cccn3c2c1)C1CC1 CHEMBL1978448 pKi 158.49 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 158.49 nM
CN1CCN(c2cnc(NC3=N/C(=C\c4ccc5ncsc5c4)C(=O)N3)cn2)CC1 CHEMBL5426807 IC50 159.0 nM
CCSC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL5181355 IC50 160.0 nM
O=C1NC(Nc2ccc(O)c(F)c2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5181008 IC50 170.0 nM
NCCOCCOCCOCCOc1ccc(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)cc1 CHEMBL3092863 IC50 180.0 nM
O=C1NC(N[C@H]2CN3CCC2CC3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5428107 IC50 199.0 nM
Cc1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 CHEMBL1989646 pKi 199.53 nM
CN(C)c1cccc2c(S(=O)(=O)N(CCN)c3cncc(-c4ccc5cnccc5c4)c3)cccc12 CHEMBL1967544 pKi 199.53 nM
CC(C)Cn1c(N)nc2ccc(-c3c(-c4ccc(F)cc4)nc4sccn34)cc21 CHEMBL1965423 pKi 199.53 nM
NC(=O)c1cccc2[nH]c(-c3ccncc3)nc12 CHEMBL1990482 pKi 199.53 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4ccccc4F)c3)cc21 CHEMBL226471 pKi 199.53 nM
NCCC(C(=O)Nc1ccc2[nH]ncc2c1)c1ccc(Cl)c(Cl)c1 CHEMBL1998121 pKi 199.53 nM
NCCOCCOCCOc1ccc(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)cc1 CHEMBL3092862 IC50 200.0 nM
Cn1cc(-c2ccc3cnc(NC(=O)C4CCN(S(C)(=O)=O)CC4)cc3c2)cn1 CHEMBL5285332 IC50 208.9 nM
COc1ccc2c(c1)[nH]c1c(C)nccc12 CHEMBL269538 IC50 210.0 nM
O=C1NC(N[C@@H]2CCCCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5414514 IC50 217.0 nM
CC1(C)C2CCC1(C)[C@H](NC1=N/C(=C\c3ccc4ncsc4c3)C(=O)N1)C2 CHEMBL5412900 IC50 223.0 nM
COc1ccc2nc3ccc(OC)cc3c(SCCCN)c2c1 CHEMBL5095897 IC50 223.1 nM
CC(C)C[C@@H](CF)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5438412 IC50 227.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL1802358 IC50 230.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2c(c1)CCO2 CHEMBL5208980 IC50 240.0 nM
NC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL5203292 IC50 240.0 nM
NC(COc1cncc(-c2ccc3c(c2)CC(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL1967302 pKi 251.19 nM
CS(=O)(=O)NCCOc1cncc(-c2ccc3cnccc3c2)c1 CHEMBL1964804 pKi 251.19 nM
CN(C)CC(=O)NC(COc1cncc(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1991725 pKi 251.19 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccccc4)c3)cc12 CHEMBL2002726 pKi 251.19 nM
Nc1nnc(-c2cc3c(Oc4ccc(Cl)cc4)cncc3s2)o1 CHEMBL1994830 pKi 251.19 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 251.19 nM
CO[C@@H]1CCCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5440511 IC50 268.0 nM
O=C1NC(NC2CCCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5283849 IC50 282.0 nM
O=C1NC(NC2CCCC(F)(F)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5411888 IC50 296.0 nM
O=C1NC(NC2CCC(F)(F)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5427398 IC50 299.0 nM
CC(C)(C)NC(=O)OC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5421442 IC50 299.0 nM
CCSC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1C CHEMBL5187895 IC50 300.0 nM
COc1cc(/C=C2\N=C(Nc3ccc(N4CCCCC4)cc3)NC2=O)ccc1O CHEMBL5181028 IC50 300.0 nM
COC(=O)[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)C(C)O CHEMBL5401116 IC50 302.0 nM
Cn1ncc2cc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)ccc21 CHEMBL5416744 IC50 307.0 nM
O=C1NC(Nc2ccccn2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5206744 IC50 310.0 nM
CC(C)C[C@H](CO)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5412105 IC50 310.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5426285 IC50 310.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 316.23 nM
Nc1ncnc2c1sc1ncnc(N)c12 CHEMBL1976090 pKi 316.23 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cnc4c(-c5cnn(C)c5)cnn4c3N)cc2)c1 CHEMBL508928 pKi 316.23 nM
O=C(O)c1c2c(nc3ccccc13)C(=C1CCCC1)CC2 CHEMBL1996831 pKi 316.23 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 pKi 316.23 nM
CCCCOc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1996817 pKi 316.23 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3ccnc(N)n3)n2n1 CHEMBL4084364 IC50 320.0 nM
CC(C)[C@@H](CO)Nc1ccc2ncc(-c3cccnc3)n2n1 CHEMBL4074132 IC50 320.0 nM
Cc1ccc(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)cc1 CHEMBL1803084 IC50 320.0 nM
O=C1NC(N[C@H](CO)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429783 IC50 323.0 nM
Cc1nc2ccc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)cc2s1 CHEMBL5407040 IC50 324.0 nM
CO[C@@H]1CCCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5428629 IC50 329.0 nM
O=C1NC(NC2CCCSC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5405233 IC50 335.0 nM
O=C1NC(NC2CC3CCC2C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5412998 IC50 337.0 nM
O=C1NC(NC2CC23CCCCC3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5434921 IC50 343.0 nM
O=C1CC[C@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CN1 CHEMBL5433242 IC50 346.0 nM
O=C1NC(NC2C3CC4CC(C3)CC2C4)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5417207 IC50 349.0 nM
O=C1NC(Nc2cccc(F)c2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5196066 IC50 350.0 nM
O=C1NC(Nc2ccccn2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5417527 IC50 350.0 nM
O=C1NC(NCC(O)C2CCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5436133 IC50 357.0 nM
CC(C)c1cnn2c(NCc3ccc(-c4ccccn4)cc3)nc(N[C@H]3CC[C@H](N)CC3)nc12 CHEMBL4284209 IC50 380.0 nM
O=C1NC(N[C@@H]2CCC[C@@H](O)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5420497 IC50 381.0 nM
O=C1NC(N[C@H]2CCC[C@H](O)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5438325 IC50 384.0 nM
CO[C@H]1CCC[C@@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5427842 IC50 385.0 nM
CN1CC[C@@](C)(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1=O CHEMBL5429707 IC50 390.0 nM
O=C1NC(N[C@@H]2CCC[C@@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5415622 IC50 395.0 nM
COC[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5401217 IC50 395.0 nM
Cn1ccc(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)n1 CHEMBL5407529 IC50 395.0 nM
COc1cccc(C(=O)Nc2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982924 pKi 398.11 nM
NC(COc1cncc(-c2ccc3[nH]c(=O)oc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1987679 pKi 398.11 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 398.11 nM
NC(COc1cncc(C=Cc2ccncc2)c1)Cc1c[nH]c2ccccc12 CHEMBL1974935 pKi 398.11 nM
c1cnc2nc(-c3ccc4[nH]ncc4c3)c(NC3CCCCC3)n2c1 CHEMBL1682552 pKi 398.11 nM
[2H]C1([2H])Oc2ccc(/C=C3\N=C(Nc4ccccc4)NC3=O)cc2O1 CHEMBL5199422 IC50 400.0 nM
CN1CCC2(CC1)CC(NC1=N/C(=C\c3ccc4ncsc4c3)C(=O)N1)C2 CHEMBL5426588 IC50 403.0 nM
O=C1NC(NCCCn2ccnc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5398474 IC50 409.0 nM
CSC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL5187753 IC50 410.0 nM
CO[C@@H]1CCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5408907 IC50 417.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2c(c1)OCCO2 CHEMBL5194689 IC50 420.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2c(c1)CCCO2 CHEMBL5207974 IC50 420.0 nM
OCCN1CCN(c2ccc3ncc(-c4cccc(Cl)c4)n3n2)CC1 CHEMBL4071013 IC50 430.0 nM
O=C1NC(NCc2ccccc2C(F)(F)F)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430415 IC50 434.0 nM
CC(=O)N1CCc2ccc(NC3=N/C(=C\c4ccc5ncsc5c4)C(=O)N3)cc21 CHEMBL5433644 IC50 443.0 nM
CN1CCN(c2cnc(NC3=N/C(=C\c4ccc5ncsc5c4)C(=O)N3)nc2)CC1 CHEMBL5398195 IC50 450.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(C=O)c3)n2n1 CHEMBL4093104 IC50 460.0 nM
O=C1NC(Nc2nncs2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5424295 IC50 460.0 nM
CCNC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL1803082 IC50 470.0 nM
O=C1NC(NC(CF)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5404644 IC50 477.0 nM
CNC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL5200677 IC50 480.0 nM
O=C1NC(NC2CCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430357 IC50 482.0 nM
O=C1NC(N[C@@H]2CN3CCC2CC3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5434213 IC50 483.0 nM
O=C1NC(NC[C@@H](O)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5428132 IC50 493.0 nM
CC(C)C[C@@H](CO)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5408047 IC50 493.4 nM
O=C1NC(NC2CCCCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5424272 IC50 495.0 nM
Cc1cc(NC(=O)CCNC(=O)Nc2nc(C)c(-c3ccc(-n4cccn4)cc3)s2)no1 CHEMBL1986603 pKi 501.19 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCCNC(C)=O)cc2NC3=O)ccc1O CHEMBL1975500 pKi 501.19 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc1)CCN2 CHEMBL411903 pKi 501.19 nM
COc1ccc(-c2cc3nccn3c(Nc3ncccc3C(N)=O)n2)cc1OC CHEMBL1190711 pKi 501.19 nM
NC(Cc1c[nH]c2ccccc12)C(=O)Nc1cncc(C=Cc2ccncc2)c1 CHEMBL1983945 pKi 501.19 nM
COc1cc(C=C(C#N)c2nc3cc(C)ccc3[nH]2)c(Br)cc1O CHEMBL2000345 pKi 501.19 nM
Cc1nc(COc2ccccc2Cl)sc1-c1ccnc(N)n1 CHEMBL1375640 pKi 501.19 nM
O=C1NC(N[C@@H]2CCCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5427523 IC50 506.0 nM
O/N=C/c1cccc(-c2cnc3ccc(Cl)nn23)c1 CHEMBL4077159 IC50 510.0 nM
CCCSC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL5206143 IC50 510.0 nM
O=C1NC(N[C@@H](CO)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5404544 IC50 513.0 nM
CC(=O)Nc1cccc(Nc2ccc3ncc(-c4cccc(NC(C)=O)c4)n3n2)c1 CHEMBL4102871 IC50 520.0 nM
CO[C@H]1CCCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5411157 IC50 528.0 nM
O=C1NC(N2CCCCC2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5201763 IC50 530.0 nM
C[C@@H]1CCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5433142 IC50 531.0 nM
O=C1NC(N[C@@H]2CCC[C@H](O)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5403037 IC50 549.0 nM
COC(=O)[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)C(C)C CHEMBL5416274 IC50 560.0 nM
O=C1NC(N[C@H]2CCCCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5423580 IC50 579.0 nM
CC1(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CCNC1=O CHEMBL5423406 IC50 592.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cc4cc(Br)ccc4[nH]3)n2n1 CHEMBL4082981 IC50 610.0 nM
O=C1NC(N[C@H]2CCCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5413726 IC50 611.0 nM
CCCSC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1C CHEMBL5194491 IC50 620.0 nM
CNC(=O)c1cc2c(-c3ccccc3F)n[nH]c2s1 CHEMBL1977681 pKi 630.96 nM
OCCNc1cc2cc(-c3cccnc3)ccc2cn1 CHEMBL1990912 pKi 630.96 nM
NCCCOc1cc2c(c(-c3ccc(Nc4nc5ccc(Cl)cc5o4)cc3)c1)CNC2=O CHEMBL2002479 pKi 630.96 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCc4cccc(F)c4)cc2NC3=O)ccc1O CHEMBL2000832 pKi 630.96 nM
COc1cc(C=C2SC(=Nc3ccccc3)NC2=O)ccc1O CHEMBL1970522 pKi 630.96 nM
COc1ccc2c(NC(=O)Nc3cccc(C(F)(F)F)n3)ccnc2c1 CHEMBL1982660 pKi 630.96 nM
CCOc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL424872 pKi 630.96 nM
COc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1OC CHEMBL1991078 pKi 630.96 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3c(C)sc4ncnc(N)c34)cc2)c1 CHEMBL371206 pKi 630.96 nM
CCCS(=O)(=O)Nc1ccc(-c2ccc3[nH]nc(N)c3c2)cc1 CHEMBL1992342 pKi 630.96 nM
NC(=O)Cn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL1985095 pKi 630.96 nM
Cc1cc(O)ccc1-n1cc(C(N)=O)c(=O)c2ccc(-c3ccncc3)cc21 CHEMBL340921 pKi 630.96 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1986499 pKi 630.96 nM
CSc1ccc2nc3c(c(Cl)c2c1)CCNC3=O CHEMBL1985074 pKi 630.96 nM
O=C1NC(N[C@@H]2CCCCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5439952 IC50 631.0 nM
CN1CCC(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CC1 CHEMBL5415615 IC50 647.0 nM
CCCNC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL1803079 IC50 650.0 nM
CCOC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5409730 IC50 650.0 nM
CC(C)C[C@H](CF)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5426735 IC50 657.0 nM
CC(C)CN1CCC(C(=O)Nc2cc3cc(-c4cnn(C)c4)ccc3cn2)CC1 CHEMBL5289681 IC50 682.8 nM
O=C1NC(Nc2cncnc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5407276 IC50 688.0 nM
CC1(C)CCC(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CO1 CHEMBL5436147 IC50 692.0 nM
O=C1NC(NC(CO)C2CCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5415462 IC50 695.0 nM
O=C1NC(Nc2cccnc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5427325 IC50 695.0 nM
Cn1ncc2cc(/C=C3\N=C(NC4CCCCCC4)NC3=O)ccc21 CHEMBL5409493 IC50 706.0 nM
O=C1NC(N[C@@H]2CCCC[C@@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5437778 IC50 706.0 nM
O=C1NC(Nc2cccc(OC(F)F)c2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5409693 IC50 706.0 nM
O=C1NC(NC2CCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5439694 IC50 708.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5418020 IC50 710.0 nM
O=C1NC(N[C@H]2CCCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429703 IC50 721.0 nM
O=C1NC(NC2CCCCCC2)=N/C1=C\c1ccc2[nH]cnc2c1 CHEMBL5408457 IC50 737.0 nM
CO[C@@H]1Cc2ccccc2[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5414635 IC50 741.0 nM
O=C1NC(N[C@@H]2CCCC[C@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5401675 IC50 753.0 nM
Cn1cnc2ccc(/C=C3\N=C(NC4CCCCCC4)NC3=O)cc21 CHEMBL5423245 IC50 758.0 nM
O=C1NC(N[C@@H]2CCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429789 IC50 759.0 nM
O=c1cc(-c2ccncc2)nc(NC2CCCCC2)[nH]1 CHEMBL1958401 pKi 794.33 nM
NCC(O)C(O)Cn1cc(I)c2c(N)ncnc21 CHEMBL1975534 pKi 794.33 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 pKi 794.33 nM
Nc1ncnc2c1c(I)nn2C1CCC(O)CC1 CHEMBL1996791 pKi 794.33 nM
c1cnc2nc(-c3ccc4[nH]ncc4c3)cn2c1 CHEMBL1682540 pKi 794.33 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 794.33 nM
NCC(NC(=O)c1ccc(-c2ccncc2)cc1)c1ccccc1 CHEMBL1990254 pKi 794.33 nM
CCCOc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL2007296 pKi 794.33 nM
Cc1ccc(C)c(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)c1 CHEMBL5179457 IC50 800.0 nM
O=C1NC(N[C@H]2CC[C@H](O)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5422936 IC50 805.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1C CHEMBL5085086 IC50 806.0 nM
O=C1NC(N[C@@H]2c3ccccc3C[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5398161 IC50 808.0 nM
O=C1NC(NC2CCC(F)(F)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5432739 IC50 818.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1C1CC1 CHEMBL5406672 IC50 841.9 nM
O=C1NC(NC2COCCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5421636 IC50 845.0 nM
O=C1NC(N[C@H]2c3ccccc3C[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429404 IC50 853.0 nM
CN1C(=O)/C(=C/c2ccc3c(c2)OCO3)N=C1Nc1ccccc1 CHEMBL1803069 IC50 870.0 nM
O=C1NC(NC2CC3(CCC3)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5427895 IC50 873.0 nM
O=C1NC(N[C@@H]2COCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5431345 IC50 873.0 nM
CN1CCCC(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5420670 IC50 887.0 nM
CCN1C(=O)/C(=C/c2ccc3ncsc3c2)N=C1N[C@@H](COC)CC(C)C CHEMBL5433334 IC50 889.2 nM
O=C1NC(NC[C@H](O)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430262 IC50 909.0 nM
COc1ccc2ncc(-c3ccc4[nH]ccc4c3)n2n1 CHEMBL4079347 IC50 910.0 nM
O=C1NC(NC2CCNCC2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5193677 IC50 910.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(/C=N/O)c3)n2n1 CHEMBL4065432 IC50 920.0 nM
O=C1NC(NCc2cccnc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5395707 IC50 921.0 nM
CC[C@@H](CO)N(C(C)=O)c1ccc2ncc(-c3cccc(NC(C)=O)c3)n2n1 CHEMBL4092673 IC50 930.0 nM
O=C1NC(N2CCCC2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5175458 IC50 930.0 nM
O=C1NC(Nc2ccc(F)cc2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5180765 IC50 930.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2c(c1)CCO2 CHEMBL5394613 IC50 934.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccnc3)n2n1 CHEMBL4100956 IC50 950.0 nM
Cc1ccc(NC2=N/C(=C\c3ccc4c(c3)OCO4)C(=O)N2)c(C)c1 CHEMBL5170033 IC50 950.0 nM
CC[C@@H](CO)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5437946 IC50 951.0 nM
O=C1NC(NC2CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5400270 IC50 960.0 nM
O=C1NC(N[C@H]2CCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5424363 IC50 966.0 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL2005936 pKi 1000.0 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 1000.0 nM
CC(C)Oc1ccc(-c2noc(-c3ccc(NC4CCC(C(=O)O)C4)cc3)n2)cc1C(F)(F)F CHEMBL1981947 pKi 1000.0 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3I)cc12 CHEMBL1975128 pKi 1000.0 nM
O=C(Nc1ccc2[nH]ncc2c1)c1cccc(F)c1 CHEMBL1461728 pKi 1000.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 pKi 1000.0 nM
OCC(CO)Nc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1992922 pKi 1000.0 nM
O=c1[nH]cnc2c1sc1c(Cl)ccc(Cl)c12 CHEMBL583144 pKi 1000.0 nM
Oc1ccc(-c2n[nH]c(Nc3cccc(Cl)c3)c2-c2ccc(O)cc2)cc1 CHEMBL1985092 pKi 1000.0 nM
COc1ccc(-c2cnc3c(Br)cnn3c2)cc1 CHEMBL443962 pKi 1000.0 nM
O=C(Nc1cnccn1)Nc1ccnc2c(C(F)(F)F)cccc12 CHEMBL1994538 pKi 1000.0 nM
O=C(NN=Cc1ccc(O)cc1O)Nc1cccc2nsnc12 CHEMBL1999811 pKi 1000.0 nM
N#Cc1ccc2[nH]c(O)c(-c3ccc(CN4CCOCC4)cn3)c2c1 CHEMBL1969664 pKi 1000.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 1000.0 nM
Oc1ccc(Nc2[nH]nc(-c3ccc(O)cc3)c2-c2ccc(O)cc2)cc1 CHEMBL1969042 pKi 1000.0 nM
CN(C)CC/N=C1/NC(=O)/C(=C/c2ccc3ncccc3c2)S1 CHEMBL3730389 pIC50 1000.0 nM