CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccc(C4CC4)nc3)c12 CHEMBL4637520 IC50 0.2 nM
CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccc(C(F)F)nc3)c12 CHEMBL4637096 IC50 0.2 nM
CC(C)N1Cc2cc(C(F)(F)F)ncc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC(C1=O)C23 CHEMBL4870920 IC50 0.2 nM
CNC(=O)CCc1ccc(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnnc23)c(C)n1 CHEMBL4755687 pKd 0.2455 nM
CC(=O)N1CCN(c2ccc([C@H]3CN(C4CCc5cccc(F)c54)C[C@@H]3N(C)C)cc2)CC1 CHEMBL4060827 Ki 0.29 nM
CN(C)[C@H]1CC(C2CCc3cccc(F)c32)C[C@@H]1c1ccc(N2CCN(S(C)(=O)=O)CC2)cc1 CHEMBL4093096 Ki 0.3 nM
CC(=O)N1CCN(c2ccc([C@H]3CN([C@H]4CCc5cccc(F)c54)C[C@@H]3N(C)C)cc2)CC1 CHEMBL4084398 Ki 0.3 nM
CN(C)[C@H]1CN(C2CCc3cccc(F)c32)C[C@@H]1c1ccc(N2CCN(S(C)(=O)=O)CC2)cc1 CHEMBL4104741 Ki 0.3 nM
CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccc(C(F)(F)F)nc3)c12 CHEMBL4638412 IC50 0.3 nM
CN(C)[C@@H]1CN(C2CCc3cccc(F)c32)C[C@H]1c1ccc(N2CCN(S(C)(=O)=O)CC2)cc1 CHEMBL5181703 Ki 0.3 nM
CC[C@H](C)C1NC(=O)[C@H](CCCCN)NC(=O)[C@@](C)(NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)CCC/C=C/CCC[C@@](C)(C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)O)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CC(C)C)NC1=O CHEMBL5289498 Kd 0.32 nM
CS(=O)(=O)c1ccc(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnc(S(C)(=O)=O)c23)cc1 CHEMBL4645324 IC50 0.4 nM
CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccc(F)cc3)c12 CHEMBL4643880 IC50 0.4 nM
Cc1ccc(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnc(S(C)(=O)=O)c23)cn1 CHEMBL4645310 IC50 0.4 nM
Cc1nc(C(F)(F)F)ccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnc(S(C)(=O)=O)c12 CHEMBL4644746 IC50 0.4 nM
Cn1ncc2c1CNC(=O)C1N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C2C13 CHEMBL4865691 IC50 0.4 nM
Cc1ncccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4755618 Kd 0.4 nM
CN(C)[C@H]1CN(C2CCc3cccc(F)c32)C[C@@H]1C1CCN(c2ccc(C(N)=O)cn2)CC1 CHEMBL4076017 Ki 0.45 nM
Cc1ccc(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnc(S(C)(=O)=O)c23)c(C)n1 CHEMBL4635558 IC50 0.5 nM
Cn1cc(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnc(S(C)(=O)=O)c23)cn1 CHEMBL4642335 IC50 0.5 nM
O=C1NCc2ccccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 CHEMBL4851576 IC50 0.5 nM
Cc1ncccc1-c1cnc(NCc2c(F)cc(N)c3c2CCO3)n2cnnc12 CHEMBL4759335 Kd 0.5 nM
Cc1nc(CCC(=O)NCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)ccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4779022 pKd 0.537 nM
Cc1nc(CCC(=O)NCCCCC(=O)N[C@@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)ccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL5275319 pKd 0.537 nM
O=C1NCc2cc(F)ccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 CHEMBL4872891 IC50 0.6 nM
CN1Cc2cc(C(F)(F)F)ncc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC(C1=O)C23 CHEMBL4869420 IC50 0.6 nM
CCN1Cc2cc(C(F)(F)F)ncc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC(C1=O)C23 CHEMBL4877375 IC50 0.6 nM
O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1CC1CCOCC1)C23 CHEMBL4860499 IC50 0.6 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COc2ccc(OCCNC(=O)CCc3ccc(-c4cnc(NCc5c(F)ccc6c5CCO6)n5cnnc45)c(N)n3)cc2)C(C)(C)C)cc1 CHEMBL5180485 pKd 0.631 nM
Cc1cccc(F)c1CN1C[C@H](C2CCN(c3cnc(C(N)=O)cn3)CC2)[C@@H](N(C)C)C1 CHEMBL4073166 Ki 0.65 nM
CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccccc3)c12 CHEMBL4640949 IC50 0.7 nM
O=C1NCc2ncccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 CHEMBL4873268 IC50 0.7 nM
Cc1ccc2c(n1)CNC(=O)C1N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C2C13 CHEMBL4861749 IC50 0.7 nM
O=C1NCc2cc(C(F)(F)F)ncc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 CHEMBL4859559 IC50 0.7 nM
O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1C1CCOCC1)C23 CHEMBL4850823 IC50 0.7 nM
Cc1cccc(F)c1CN1C[C@H](c2cn(C)c3c(N4CCN(C)C(=O)C4)cccc23)[C@@H](N(C)C)C1 CHEMBL4065766 Ki 0.74 nM
CS(=O)(=O)c1ccc(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnc(S(C)(=O)=O)c23)cn1 CHEMBL4640556 IC50 0.8 nM
O=C1NCc2c(F)cccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 CHEMBL4862163 IC50 0.8 nM
O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1C1CCC1)C23 CHEMBL4856280 IC50 0.8 nM
O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1C1CC(F)(F)C1)C23 CHEMBL4878932 IC50 0.8 nM
Cc1cc(S(C)(=O)=O)ccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnc(S(C)(=O)=O)c12 CHEMBL4649099 IC50 0.9 nM
Cc1nc(CCC(=O)NCCOc2ccc(OCC(=O)N[C@@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)cc2)ccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL5287008 pKd 0.955 nM
Cc1cccc(F)c1CN1C[C@H](c2cn(C)c3c(C(=O)N4CC(F)C4)cccc23)[C@@H](N(C)C)C1 CHEMBL4077363 Ki 1.0 nM
CN(C)[C@H]1CN([C@H]2CCc3cccc(F)c32)C[C@@H]1c1cn(C)c2ccccc12 CHEMBL4080018 Ki 1.0 nM
CC1CC(N2Cc3cc(C(F)(F)F)ncc3C3=CN=C(NCc4c(F)ccc5c4CCO5)N4C=NC(C2=O)C34)CC(C)O1 CHEMBL4856160 IC50 1.0 nM
CN1CCC(CN2Cc3cc(C(F)(F)F)ncc3C3=CN=C(NCc4c(F)ccc5c4CCO5)N4C=NC(C2=O)C34)CC1 CHEMBL4854206 IC50 1.0 nM
Cc1nc(CCC(=O)NCCOc2ccc(OCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)cc2)ccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4753773 pKd 1.0 nM
O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1CC1(O)CC1)C23 CHEMBL4850847 IC50 1.1 nM
O=C1NCc2cc(C(F)(F)F)ccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 CHEMBL4847943 IC50 1.2 nM
Cc1ncccc1-c1cnc(NCc2c(F)cc(F)c3c2CCO3)n2cnnc12 CHEMBL4754048 Kd 1.2 nM
CC(F)(F)CN1Cc2cc(C(F)(F)F)ncc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC(C1=O)C23 CHEMBL4861394 IC50 1.4 nM
O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1C1CC1)C23 CHEMBL4871261 IC50 1.5 nM
O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1CC(F)F)C23 CHEMBL4854800 IC50 1.6 nM
CC(C)(O)CN1Cc2cc(C(F)(F)F)ncc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC(C1=O)C23 CHEMBL4849266 IC50 1.6 nM
O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1CC1COCCO1)C23 CHEMBL4858089 IC50 1.6 nM
Cc1ncccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnc(S(C)(=O)=O)c12 CHEMBL4633469 IC50 1.8 nM
CC1(O)CC(CN2Cc3cc(C(F)(F)F)ncc3C3=CN=C(NCc4c(F)ccc5c4CCO5)N4C=NC(C2=O)C34)C1 CHEMBL4858561 IC50 1.8 nM
CCN(c1cc(-c2ccc(CN3CCOCC3)cc2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1 CHEMBL3414621 IC50 2.0 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCN(c4ccccn4)CC3)cc2)[C@@H](N(C)C)C1 CHEMBL4059553 Ki 2.1 nM
Cc1ncccc1-c1cnc(NCc2c(F)cc(Cl)c3c2CCO3)n2cnnc12 CHEMBL4762963 Kd 2.4 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(-c3cnn(CC(N)=O)c3)cc2)[C@@H](N(C)C)C1 CHEMBL4068192 Ki 2.6 nM
CC(=O)N1CCN(c2ccc([C@H]3CN(Cc4c(C)cccc4F)C[C@@H]3N(C)C)cc2)CC1 CHEMBL4081496 Ki 2.6 nM
c1coc(CNc2ncc(-c3cccc4cc[nH]c34)c3nncn23)c1 CHEMBL5416457 IC50 2.72 nM
CC(=O)N1CCC(c2cnc(NCc3c(F)ccc4c3CCO4)n3cnc(S(C)(=O)=O)c23)CC1 CHEMBL4639197 IC50 2.8 nM
CC(=O)N1CCN(c2ccc([C@H]3CN([C@@H]4CCc5cccc(F)c54)C[C@@H]3N(C)C)cc2)CC1 CHEMBL4071358 Ki 3.0 nM
COc1ccc([C@H]2CN(C3CCc4cccc(F)c43)C[C@@H]2N(C)C)cc1OC CHEMBL4102320 Ki 3.0 nM
CN(C)C(=O)c1cc(-c2cnc(NCc3c(F)ccc4c3CCO4)c3cn[nH]c(=O)c23)n(C)n1 CHEMBL4851414 IC50 3.0 nM
CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(C3CCN(S(=O)(=O)C4CC4)CC3)c12 CHEMBL4634654 IC50 3.1 nM
O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1CC(F)(F)F)C23 CHEMBL4857414 IC50 3.2 nM
CP(C)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccccc3)c12 CHEMBL4648753 IC50 3.6 nM
O=C1NCc2nc(C(F)(F)F)ccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 CHEMBL4855616 IC50 3.6 nM
Cc1cc(-c2cnc(NCc3c(F)ccc4c3CCO4)c3cn[nH]c(=O)c23)n(C)n1 CHEMBL4859723 pIC50 3.981 nM
Cc1cccc(F)c1CN1C[C@H](c2cn(C)c3ccccc23)[C@@H](N(C)C)C1 CHEMBL4085428 Ki 4.0 nM
O=C1NCc2ccc(F)cc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 CHEMBL4869720 IC50 4.1 nM
[2H]C([2H])(Nc1ncc(-c2cccnc2C)c(=O)n1C)c1c(F)ccc2c1CCO2 CHEMBL5201204 IC50 4.5 nM
[2H]C([2H])(Nc1ncc(-c2cccnc2C)c(=O)n1C)c1cc(F)cc2c1CCO2 CHEMBL5268403 IC50 4.5 nM
[2H]C([2H])(Nc1ncc(-c2cccnc2C)c(=O)[nH]1)c1c(F)ccc2c1CCO2 CHEMBL5269445 IC50 4.5 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(C3=CCN(C(=O)CS(C)(=O)=O)CC3)nc2)[C@@H](N(C)C)C1 CHEMBL4072329 Ki 4.6 nM
Cc1cccc(F)c1CN1C[C@H](c2cn(CC(=O)N(C)C)c3ncccc23)[C@@H](N(C)C)C1 CHEMBL4077273 Ki 5.3 nM
Cn1nccc1-c1cnc(NCc2c(F)ccc3c2CCO3)c2cn[nH]c(=O)c12 CHEMBL4855253 IC50 6.0 nM
c1coc(CNc2ncc(-c3ccc(CN4CCCC4)cc3)c3nncn23)c1 CHEMBL4103319 IC50 7.0 nM
CC(C)n1ccc2cc(-c3cnc(NCc4ccco4)n4cnnc34)ccc21 CHEMBL5433498 IC50 7.19 nM
CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(C3CCS(=O)(=O)CC3)c12 CHEMBL4642454 IC50 7.8 nM
CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(C3CCN(S(C)(=O)=O)CC3)c12 CHEMBL4649861 IC50 7.9 nM
CNC(=O)c1ccc(-c2cnc(NCc3c(F)ccc4c3CCO4)c3cn[nH]c(=O)c23)c(C)n1 CHEMBL4847216 pIC50 7.943 nM
CNC(=O)c1ncc(-c2cnc(NCc3c(F)ccc4c3CCO4)c3cn[nH]c(=O)c23)n1C CHEMBL4850478 pIC50 7.943 nM
CN(C)[C@H]1CN(Cc2c(F)cc(O)cc2Br)C[C@@H]1c1cn(C)c2ccccc12 CHEMBL4100850 Ki 8.0 nM
CN(C)Cc1ccc(-c2cc(C#N)c(NCc3ccco3)n3cnnc23)cc1 CHEMBL4088683 IC50 9.0 nM
CN(C)Cc1ccc(-c2cc(C#N)c(NCc3ccoc3)n3cnnc23)cc1 CHEMBL4079806 IC50 9.0 nM
O=C1NCc2ccc(C(F)(F)F)cc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 CHEMBL4869748 IC50 9.2 nM
c1coc(CNc2ncc(-c3ccc4c(ccn4C4CC4)c3)c3nncn23)c1 CHEMBL5427063 IC50 9.59 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCN(c4ccncc4)CC3)cc2)[C@@H](N(C)C)C1 CHEMBL4079307 IC50 10.0 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(S(C)(=O)=O)cc2)[C@@H](N(C)C)C1 CHEMBL4072980 Ki 10.0 nM
CN(C)[C@H]1CN(Cc2c(F)cccc2Br)C[C@@H]1c1cn(C)c2ccccc12 CHEMBL4075197 Ki 10.0 nM
CN(C)[C@H]1CN(C2CCc3cccc(F)c32)C[C@@H]1c1cn(C)c2ccccc12 CHEMBL4795893 Ki 11.0 nM
Cn1ccc2cc(-c3cnc(NCc4ccco4)n4cnnc34)ccc21 CHEMBL5396170 IC50 11.21 nM
O=C1NCc2sccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 CHEMBL4877695 IC50 11.3 nM
c1coc(CNc2ncc(-c3ccc4[nH]ccc4c3)c3nncn23)c1 CHEMBL5409314 IC50 11.57 nM
c1coc(CNc2ncc(-c3ccc4c(ccn4C4CCCCC4)c3)c3nncn23)c1 CHEMBL5418657 IC50 11.77 nM
COc1ccc([C@H]2CN(Cc3c(C)cccc3F)C[C@@H]2N(C)C)cc1OC CHEMBL4078052 Ki 12.0 nM
CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(C3CCOCC3)c12 CHEMBL4647900 IC50 12.0 nM
CS(=O)(=O)c1ccc(-c2cnc(NCc3ccco3)n3cnnc23)cc1 CHEMBL4065484 IC50 12.2 nM
Cc1nc(CO)ccc1-c1cnc(NCc2c(F)ccc3c2CCO3)c2cn[nH]c(=O)c12 CHEMBL4871456 pIC50 12.59 nM
Cc1ncc(-c2cnc(NCc3c(F)ccc4c3CCO4)c3cn[nH]c(=O)c23)n1C CHEMBL4855124 pIC50 12.59 nM
CN(C)Cc1ccc(-c2cnc(NCc3ccco3)n3cnnc23)cc1 CHEMBL4081748 IC50 13.0 nM
O=C1NCc2ccsc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 CHEMBL4847397 IC50 13.2 nM
O=C1NCCc2ccccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 CHEMBL4858622 IC50 13.8 nM
CS(=O)(=O)c1cnc(NCc2ccco2)n2cnnc12 CHEMBL5418721 IC50 14.13 nM
N#Cc1c[nH]c2ccc(-c3cnc(NCc4ccco4)n4cnnc34)cc12 CHEMBL5418546 IC50 14.28 nM
Cc1nc(C(=O)N(C)C)ccc1-c1cnc(NCc2c(F)ccc3c2CCO3)c2cn[nH]c(=O)c12 CHEMBL4850269 IC50 15.0 nM
Cc1ncccc1-c1cnc(NCc2c(F)cc(C#N)c3c2CCO3)n2cnnc12 CHEMBL4748924 Kd 15.0 nM
Fc1cccc(Cn2ccc3cc(-c4cnc(NCc5ccco5)n5cnnc45)ccc32)c1 CHEMBL5428279 IC50 15.78 nM
Cc1nn(C)cc1-c1cnc(NCc2c(F)ccc3c2CCO3)c2cn[nH]c(=O)c12 CHEMBL4870866 pIC50 15.85 nM
CCn1ccc2cc(-c3cnc(NCc4ccco4)n4cnnc34)ccc21 CHEMBL5405615 IC50 16.18 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(C(=O)N(C)C)cc2)[C@@H](N(C)C)C1 CHEMBL4089371 Ki 18.0 nM
CC(=O)N1CCN(c2ccc([C@@H]3CN([C@@H]4CCc5cccc(F)c54)C[C@H]3N(C)C)cc2)CC1 CHEMBL4077899 Ki 18.0 nM
COc1ccc([C@H]2CN(Cc3c(F)cccc3Br)C[C@@H]2N(C)C)cc1OC CHEMBL4079004 Ki 18.0 nM
CCOC(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccccc3)c12 CHEMBL4645381 IC50 18.0 nM
NC(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccccc3)c12 CHEMBL4869208 IC50 18.8 nM
CN(C)Cc1ccc(-c2cnc(NCc3ccoc3)n3cnnc23)cc1 CHEMBL4105572 IC50 19.0 nM
Cc1nccn1-c1cnc(NCc2c(F)ccc3c2CCO3)c2cn[nH]c(=O)c12 CHEMBL4850017 IC50 19.0 nM
O=C1Nc2ccccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 CHEMBL4861770 IC50 19.5 nM
O=C1CC2(CC2)CN1c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4856933 pIC50 19.95 nM
Cc1ncccc1-c1cnc(NCc2c(F)ccc3c2CCO3)c2cn[nH]c(=O)c12 CHEMBL4862641 pIC50 19.95 nM
CN(C)Cc1ccc2c(c1)CN(c1cnc(NCc3c(F)ccc4c3CCO4)c3cn[nH]c(=O)c13)C2=O CHEMBL4858670 pIC50 19.95 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCN(C(=O)c4ccc(Cl)cc4)CC3)cc2)[C@@H](N(C)C)C1 CHEMBL4093911 IC50 20.0 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCN(S(=O)(=O)N(C)C)CC3)cc2)[C@@H](N(C)C)C1 CHEMBL4081745 IC50 20.0 nM
CN(C)Cc1ccc(-c2cc(C#N)c(NCc3cccs3)n3cnnc23)cc1 CHEMBL4099766 IC50 20.0 nM
c1coc(CNc2ncc(-c3cccc4[nH]ccc34)c3nncn23)c1 CHEMBL5412143 IC50 20.47 nM
Fc1ccc(Cn2ccc3cc(-c4cnc(NCc5ccco5)n5cnnc45)ccc32)cc1F CHEMBL5420695 IC50 21.3 nM
c1coc(CNc2ncc(-c3ccc4cc[nH]c4c3)c3nncn23)c1 CHEMBL5406846 IC50 22.31 nM
CN(C)C(=O)c1cccc2c([C@H]3CN(Cc4c(F)cccc4Br)C[C@@H]3N(C)C)cn(C)c12 CHEMBL4068811 Ki 23.0 nM
CNC(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccccc3)c12 CHEMBL4637475 IC50 23.0 nM
CCN1CCC(c2cnc(NCc3c(F)ccc4c3CCO4)n3cnc(S(C)(=O)=O)c23)CC1 CHEMBL4634939 IC50 23.0 nM
O=C1Cc2ccccc2CN1c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4845735 IC50 24.0 nM
CNC(=O)c1cc(-c2cnc(NCc3c(F)ccc4c3CCO4)c3cn[nH]c(=O)c23)n(C)n1 CHEMBL4866431 IC50 25.0 nM
c1coc(CNc2ncc(-c3c[nH]c4ccccc34)c3nncn23)c1 CHEMBL5432878 IC50 25.74 nM
Cn1cc(-c2cnc(NCc3ccco3)n3cnnc23)c2ccccc21 CHEMBL5423657 IC50 26.09 nM
CCOC(=O)c1ncn2c(NCc3cccc4c3CCO4)ncc(-c3ccccc3)c12 CHEMBL4637975 IC50 29.0 nM
Fc1ccc2c(c1CNc1ncc(-c3ccccc3)c3c(C(F)(F)F)ncn13)CCO2 CHEMBL4638385 IC50 29.0 nM
CN(c1ncco1)c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4862266 IC50 29.0 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCN(C(=O)N4CCCC4)CC3)cc2)[C@@H](N(C)C)C1 CHEMBL4093192 IC50 30.0 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCN(c4nccs4)CC3)cc2)[C@@H](N(C)C)C1 CHEMBL4102534 IC50 30.0 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCN(c4ncccn4)CC3)cc2)[C@@H](N(C)C)C1 CHEMBL4094795 IC50 30.0 nM
COC(=O)N1CCN(c2ccc([C@H]3CN(Cc4c(C)cccc4F)C[C@@H]3N(C)C)cc2)CC1 CHEMBL4064647 IC50 30.0 nM
N#Cc1cc(-c2ccccc2F)c2nncn2c1NCc1ccco1 CHEMBL4093147 IC50 30.0 nM
c1ccc(Cn2ccc3cc(-c4cnc(NCc5ccco5)n5cnnc45)ccc32)cc1 CHEMBL5404982 IC50 31.49 nM
Cc1cccc(Cn2ccc3cc(-c4cnc(NCc5ccco5)n5cnnc45)ccc32)c1 CHEMBL5425259 IC50 34.56 nM
O=C1c2ccccc2CN1c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4846342 IC50 36.0 nM
CN(C)Cc1ccc2c(c1)CN(c1cnc(NCc3c(F)ccc4c3CCO4)n3cnnc13)C2=O CHEMBL4869385 IC50 36.0 nM
Cc1nc(CN(C)C)ccc1-c1cnc(NCc2c(F)ccc3c2CCO3)c2cn[nH]c(=O)c12 CHEMBL4863385 IC50 39.0 nM
CN(c1cccnc1)c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4866070 pIC50 39.81 nM
CN(c1ccncc1)c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4851602 pIC50 39.81 nM
CN(c1ccn(C)n1)c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4860329 pIC50 39.81 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCC(N(C)C)CC3)cc2)[C@@H](N(C)C)C1 CHEMBL4072445 IC50 40.0 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCC(N4CCOCC4)CC3)cc2)[C@@H](N(C)C)C1 CHEMBL4094127 IC50 40.0 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCC(C(=O)N(C)C)CC3)cc2)[C@@H](N(C)C)C1 CHEMBL4067345 IC50 40.0 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCN(S(=O)(=O)c4cccc(F)c4)CC3)cc2)[C@@H](N(C)C)C1 CHEMBL4086155 IC50 40.0 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCC(C)CC3)cc2)[C@@H](N(C)C)C1 CHEMBL4097336 IC50 40.0 nM
CC(=O)NC1CCN(c2ccc([C@H]3CN(Cc4c(C)cccc4F)C[C@@H]3N(C)C)cc2)CC1 CHEMBL4059817 IC50 40.0 nM
CCOC(=O)c1ncn2c(NCc3cccc4c3OCO4)ncc(-c3ccccc3)c12 CHEMBL4637141 IC50 40.0 nM
FC(F)(F)c1cccc(Cn2ccc3cc(-c4cnc(NCc5ccco5)n5cnnc45)ccc32)c1 CHEMBL5432362 IC50 41.55 nM
CC(=O)N1CCN(c2ccc([C@@H]3CN([C@H]4CCc5cccc(F)c54)C[C@H]3N(C)C)cc2)CC1 CHEMBL4092154 Ki 42.0 nM
CN(C)[C@H]1CN([C@H]2CCc3ccccc32)C[C@@H]1c1cn(C)c2ccccc12 CHEMBL4087904 Ki 45.0 nM
O=C1Oc2ccccc2CN1c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4845889 IC50 45.0 nM
CN(C)[C@H]1CN(Cc2c(F)cccc2Br)C[C@@H]1c1ccncc1 CHEMBL4065124 Ki 49.0 nM
Cc1ccsc1CNc1ncc(-c2ccc(CN(C)C)cc2)c2nncn12 CHEMBL4066526 IC50 49.0 nM
CN(C)Cc1ccc(-c2cnc(NCc3ccccc3)n3cnnc23)cc1 CHEMBL4076858 IC50 49.0 nM
Cc1ncccc1-c1cnc(NCc2c(F)ccc3c2CCO3)c2nn(CC#N)c(=O)n12 CHEMBL4845691 IC50 49.0 nM
Cc1ccc(S(=O)(=O)N2CCN(c3ccc([C@H]4CN(Cc5c(C)cccc5F)C[C@@H]4N(C)C)cc3)CC2)cc1 CHEMBL4085432 IC50 50.0 nM
CNC(=O)C1CCN(c2ccc([C@H]3CN(Cc4c(C)cccc4F)C[C@@H]3N(C)C)cc2)CC1 CHEMBL4068385 IC50 50.0 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCN(c4ccccc4)CC3)cc2)[C@@H](N(C)C)C1 CHEMBL4071195 IC50 50.0 nM
CCOC(=O)c1ncn2c(NCc3c(F)cccc3OC)ncc(-c3ccccc3)c12 CHEMBL4644450 IC50 50.0 nM
c1ccc(-c2cnc(NCc3ccco3)n3cnnc23)cc1 CHEMBL4105039 IC50 52.0 nM
CN(C)[C@H]1CN(Cc2c(F)cccc2Cl)C[C@@H]1c1cn(C)c2ccccc12 CHEMBL4095605 Ki 53.0 nM
CN(C)Cc1ccc(-c2cnc(NCc3sccc3Cl)n3cnnc23)cc1 CHEMBL4081454 IC50 53.0 nM
Cc1c[nH]c2ccc(-c3cnc(NCc4ccco4)n4cnnc34)cc12 CHEMBL5402881 IC50 55.38 nM
Cc1cccc(F)c1CN1C[C@H](c2ccccc2)[C@@H](N(C)C)C1 CHEMBL4079061 Ki 56.0 nM
CN(C)[C@H]1CN(Cc2c(F)cccc2Br)C[C@@H]1C1CCOCC1 CHEMBL4104796 Ki 59.0 nM
CCOC(=O)c1ncn2c(NCc3ccco3)ncc(-c3ccccc3)c12 CHEMBL4645585 IC50 59.0 nM
CCN1CCN(c2ccc([C@H]3CN(Cc4c(C)cccc4F)C[C@@H]3N(C)C)cc2)CC1=O CHEMBL4062781 IC50 60.0 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCC4(CC3)CNC(=O)O4)cc2)[C@@H](N(C)C)C1 CHEMBL4066590 IC50 60.0 nM
O=C1c2ccc(OCCN3CCCC3)cc2CN1c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4874700 IC50 60.0 nM
N#Cc1cc(-c2ccccc2)c2nncn2c1NCc1ccco1 CHEMBL4067448 IC50 62.0 nM
Cn1cc(-c2cnc(NCc3c(F)ccc4c3CCO4)c3cn[nH]c(=O)c23)cn1 CHEMBL4862766 pIC50 63.1 nM
CN(C)[C@H]1CN([C@H]2CCc3ccc(F)cc32)C[C@@H]1c1cn(C)c2ccccc12 CHEMBL4062773 Ki 66.0 nM
CN(C)Cc1ccc(-c2cc(C#N)c(NCc3ccon3)n3cnnc23)cc1 CHEMBL4095382 IC50 69.0 nM
CN(C)Cc1ccc(-c2cc(C#N)c(NCc3ccno3)n3cnnc23)cc1 CHEMBL4103134 IC50 69.0 nM
Cc1cc([C@H]2CN(Cc3c(C)cccc3F)C[C@@H]2N(C)C)ccc1C(=O)NCc1ccncc1 CHEMBL4075246 IC50 70.0 nM
Cc1cc([C@H]2CN(Cc3c(C)cccc3F)C[C@@H]2N(C)C)ccc1C(=O)NCc1ccccn1 CHEMBL4080065 IC50 70.0 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCn4ccnc4C3)cc2)[C@@H](N(C)C)C1 CHEMBL4063855 IC50 70.0 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCN(c4ccccc4S(C)(=O)=O)CC3)cc2)[C@@H](N(C)C)C1 CHEMBL4073232 IC50 70.0 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCC(C#N)CC3)cc2)[C@@H](N(C)C)C1 CHEMBL4094876 IC50 70.0 nM
CN(C)[C@H]1CN(Cc2c(F)cccc2Br)C[C@@H]1C1CC1 CHEMBL4086916 Ki 71.0 nM
CC(=O)N1CCC(c2cnc(NCc3c(F)ccc4c3CCO4)c3cn[nH]c(=O)c23)CC1 CHEMBL4874749 IC50 75.0 nM
CN(C)[C@H]1CN([C@H]2CCCc3ccccc32)C[C@@H]1c1cn(C)c2ccccc12 CHEMBL4084449 Ki 78.0 nM
CN(C)[C@H]1CN(Cc2c(F)cccc2Br)C[C@@H]1c1ccccc1 CHEMBL4085375 Ki 78.0 nM
c1ccc(-n2ccc3cc(-c4cnc(NCc5ccco5)n5cnnc45)ccc32)cc1 CHEMBL5401223 IC50 78.85 nM
Cc1cc([C@H]2CN(Cc3c(C)cccc3F)C[C@@H]2N(C)C)ccc1C(=O)NCc1cccnc1 CHEMBL4087938 IC50 80.0 nM
Cc1cc([C@H]2CN(Cc3c(C)cccc3F)C[C@@H]2N(C)C)ccc1C(=O)Nc1cccnc1 CHEMBL4066626 IC50 80.0 nM
Cc1cc([C@H]2CN(Cc3c(C)cccc3F)C[C@@H]2N(C)C)ccc1C(=O)Nc1ccncc1 CHEMBL4069338 IC50 80.0 nM
Cc1cc([C@H]2CN(Cc3c(C)cccc3F)C[C@@H]2N(C)C)ccc1C(=O)NCCN(C)C CHEMBL4101104 IC50 80.0 nM
Cc1cc([C@H]2CN(Cc3c(C)cccc3F)C[C@@H]2N(C)C)ccc1C(=O)NCCC1CCCN1C CHEMBL4074364 IC50 80.0 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCC(N4CCCC4=O)CC3)cc2)[C@@H](N(C)C)C1 CHEMBL4068481 IC50 80.0 nM
CN(C)[C@@H]1CN(Cc2c(F)cccc2Br)C[C@H]1c1cn(C)c2ccccc12 CHEMBL4067115 Ki 80.0 nM
CCOC(=O)c1ncn2c(NCc3ccccc3OC)ncc(-c3ccccc3)c12 CHEMBL4649754 IC50 86.0 nM
Cc1cc([C@H]2CN(Cc3c(C)cccc3F)C[C@@H]2N(C)C)ccc1C(=O)NCCN1CCN(C)CC1 CHEMBL4096569 IC50 90.0 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N(C)C3CCN(C)CC3)cc2)[C@@H](N(C)C)C1 CHEMBL4098240 IC50 90.0 nM
CC(=O)N[C@H]1CCN(c2ccc([C@H]3CN(Cc4c(C)cccc4F)C[C@@H]3N(C)C)cc2)C1 CHEMBL4089538 IC50 90.0 nM
CN(C)[C@H]1CN(Cc2c(F)cccc2Br)C[C@@H]1c1ccc(O)cc1 CHEMBL4103307 Ki 91.0 nM
CNC(=O)c1ncn2c(NCc3ccco3)ncc(-c3ccccc3)c12 CHEMBL4647928 IC50 92.0 nM
CN(C)Cc1ccc(-c2cnc(NCc3cccs3)n3cnnc23)cc1 CHEMBL4097833 IC50 93.0 nM
COc1ccccc1CNc1ncc(-c2ccc(CN(C)C)cc2)c2nncn12 CHEMBL4085389 IC50 94.0 nM
C[C@@H]1CC(=O)N(c2cnc(NCc3c(F)ccc4c3CCO4)n3cnnc23)C1 CHEMBL4874848 IC50 97.0 nM
CCN(CC)C(=O)c1ccc([C@H]2CN(Cc3c(C)cccc3F)C[C@@H]2N(C)C)cc1C CHEMBL4093361 IC50 100.0 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CC(=O)N4CCCCC4C3)cc2)[C@@H](N(C)C)C1 CHEMBL4090732 IC50 100.0 nM
CC1(C)CC(=O)N(c2cnc(NCc3c(F)ccc4c3CCO4)n3cnnc23)C1 CHEMBL4875406 IC50 100.0 nM
Cc1cc([C@H]2CN(Cc3c(C)cccc3F)C[C@@H]2N(C)C)ccc1C(=O)N(C)CC1CCCO1 CHEMBL4100912 IC50 110.0 nM
Cc1cc([C@H]2CN(Cc3c(C)cccc3F)C[C@@H]2N(C)C)ccc1C(=O)N(C)C CHEMBL4082932 IC50 110.0 nM
c1ccc(-c2cnc(NCc3ccco3)n3cncc23)cc1 CHEMBL4070157 IC50 115.0 nM
CCOC(=O)c1ncn2c(NCc3ccccc3)ncc(-c3ccccc3)c12 CHEMBL4634893 IC50 119.0 nM
CN(c1ccccc1)c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4856056 IC50 120.0 nM
CN(c1ccn(C)n1)c1cnc(NCc2c(F)ccc3c2CCO3)c2cn[nH]c(=O)c12 CHEMBL4874724 IC50 120.0 nM
CN(C)[C@H]1CN([C@@H]2CCc3cccc(F)c32)C[C@@H]1c1cn(C)c2ccccc12 CHEMBL4066584 Ki 129.0 nM
COCCN(C)C(=O)c1ccc([C@H]2CN(Cc3c(C)cccc3F)C[C@@H]2N(C)C)cc1C CHEMBL4104300 IC50 130.0 nM
Cc1cccc(F)c1CN1C[C@H](c2ccc(N3CCn4cnnc4C3)cc2)[C@@H](N(C)C)C1 CHEMBL4067443 IC50 130.0 nM
CN(C)Cc1ccc(-c2cnc(NCc3ccno3)n3cnnc23)cc1 CHEMBL4086716 IC50 130.0 nM
CCOC(=O)c1ncn2c(NCc3cc(OC)ccc3F)ncc(-c3ccccc3)c12 CHEMBL4636851 IC50 138.0 nM
Cc1cc([C@H]2CN(Cc3c(C)cccc3F)C[C@@H]2N(C)C)ccc1C(=O)N1CCCC1 CHEMBL4084649 IC50 140.0 nM
c1coc(CNc2ncc(-c3cc4ccccc4[nH]3)c3nncn23)c1 CHEMBL5399175 IC50 141.72 nM
CCOC(=O)c1ncn2c(NCc3ccc(OC)cc3F)ncc(-c3ccccc3)c12 CHEMBL4645511 IC50 145.0 nM
Cc1ccc(N2CCN(c3ccc([C@H]4CN(Cc5c(C)cccc5F)C[C@@H]4N(C)C)cc3)CC2)cc1 CHEMBL4068472 IC50 150.0 nM
CN(C)Cc1ccc(-c2cc(C#N)c(NCc3cnco3)n3cnnc23)cc1 CHEMBL4087691 IC50 150.0 nM
CN(C)Cc1ccc(-c2cnc(NCc3ccc(F)s3)n3cnnc23)cc1 CHEMBL4104753 IC50 150.0 nM
O=C1CCCN1c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4851039 IC50 150.0 nM
C[C@H]1CC(=O)N(c2cnc(NCc3c(F)ccc4c3CCO4)n3cnnc23)C1 CHEMBL4860856 IC50 150.0 nM
CC(C)n1ccc2cccc(-c3cnc(NCc4ccco4)n4cnnc34)c21 CHEMBL5436550 IC50 151.65 nM
CC(=O)N1CCCN(c2ccc([C@H]3CN(Cc4c(C)cccc4F)C[C@@H]3N(C)C)cc2)CC1 CHEMBL4078266 IC50 160.0 nM
CC(=O)N[C@@H]1CCN(c2ccc([C@H]3CN(Cc4c(C)cccc4F)C[C@@H]3N(C)C)cc2)C1 CHEMBL4089620 IC50 160.0 nM
Cc1ccc(F)c(CN2C[C@H](c3cn(C)c4ccccc34)[C@@H](N(C)C)C2)c1 CHEMBL4104253 Ki 160.0 nM
Cc1ncccc1-c1cc2c(n3cnnc13)NCc1c(F)ccc3c1[C@@H](CO3)CO2 CHEMBL5204429 Kd 163.0 nM
CC(=O)N1CCN(C(=O)c2ccc([C@H]3CN(Cc4c(C)cccc4F)C[C@@H]3N(C)C)cc2C)CC1 CHEMBL4065749 IC50 180.0 nM
CN(c1cnn(C)c1)c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4853330 IC50 180.0 nM
Cc1ccc(S(=O)(=O)n2c(C)c(-c3cnc(NCc4ccco4)n4cnnc34)c3ccccc32)cc1 CHEMBL5424697 IC50 195.75 nM
O=C(Nc1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12)c1ccccc1 CHEMBL4856470 pIC50 199.53 nM
O=C1CCCN1c1cnc(NCc2c(F)ccc3c2CCO3)c2cn[nH]c(=O)c12 CHEMBL4850902 pIC50 199.53 nM
CCOC(=O)c1ncn2c(NCc3cccc4c3OCC4)ncc(-c3ccccc3)c12 CHEMBL4638382 IC50 207.0 nM
CN(C)[C@H]1CN(Cc2c(F)cccc2Br)C[C@@H]1C1CCCCC1 CHEMBL4086565 Ki 230.0 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCNC(=O)c2ccc(-c3cnc(NCc4ccco4)n4cnnc34)cc2)C(C)(C)C)cc1 CHEMBL4749741 IC50 247.0 nM
COc1ccccc1C(=O)Nc1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4855687 pIC50 251.19 nM
O=C1c2cnccc2CN1c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4869186 pIC50 251.19 nM
Cc1cc([C@H]2CN(Cc3c(C)cccc3F)C[C@@H]2N(C)C)ccc1C(=O)N1CCN(C)CC1 CHEMBL4103551 IC50 260.0 nM
CN(C)[C@H]1CN([C@H]2CCc3ncccc32)C[C@@H]1c1cn(C)c2ccccc12 CHEMBL4073650 Ki 260.0 nM
Cc1ccc(S(=O)(=O)n2ccc3cc(-c4cnc(NCc5ccco5)n5cnnc45)ccc32)cc1 CHEMBL5396562 IC50 268.07 nM
Cc1cc([C@H]2CN(Cc3c(C)cccc3F)C[C@@H]2N(C)C)ccc1C(=O)N1CCN(CCO)CC1 CHEMBL4083977 IC50 270.0 nM
CCN1CCN(C(=O)c2ccc([C@H]3CN(Cc4c(C)cccc4F)C[C@@H]3N(C)C)cc2C)CC1 CHEMBL4066774 IC50 290.0 nM
CN(C)Cc1ccc(-c2cnc(NCc3cnco3)n3cnnc23)cc1 CHEMBL4067992 IC50 290.0 nM
Cc1cccc(F)c1CN1C[C@@H](N(C)C)[C@H](c2ccc(S(C)(=O)=O)cc2)C1 CHEMBL4093678 Ki 290.0 nM
Cc1cc([C@H]2CN(Cc3c(C)cccc3F)C[C@@H]2N(C)C)ccc1C(=O)N1CCCN(C)CC1 CHEMBL4085614 IC50 310.0 nM
Fc1ccc2c(c1CNc1ncc(Oc3ccccc3)c3nncn13)CCO2 CHEMBL4859999 pIC50 316.23 nM
N#Cc1c2c(c3cccn3c1NCc1ccco1)CN(Cc1ccccc1)CC2 CHEMBL5283723 IC50 320.0 nM
N#Cc1c2c(c3nncn3c1NCc1ccco1)CN(Cc1ccccc1)CC2 CHEMBL4096234 IC50 320.0 nM
CN(C)[C@H]1CN(Cc2ccccc2F)C[C@@H]1c1cn(C)c2ccccc12 CHEMBL4103354 Ki 330.0 nM
Cc1cc([C@H]2CN(Cc3c(C)cccc3F)C[C@@H]2N(C)C)ccc1C(=O)N1CCN(C(=O)C2CC2)CC1 CHEMBL4062979 IC50 340.0 nM
C[C@H]1CN(Cc2c(F)cccc2Br)C[C@@H]1N(C)C CHEMBL4097080 Ki 380.0 nM
Cc1ncccc1-c1cnc(NCc2c(F)ccc3c2CCO3)c2n[nH]c(=O)n12 CHEMBL4863923 pIC50 398.11 nM
CC(C)c1nc(N)n2c1C(Cc1cccc3c1OCO3)CCC2 CHEMBL4101747 IC50 430.0 nM
CN(C)[C@H]1CN(Cc2c(F)cccc2Br)C[C@@H]1c1ccccn1 CHEMBL4093134 Ki 450.0 nM
O=C(Nc1ccccc1)c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4870285 IC50 450.0 nM
COCCC(=O)Nc1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4876990 pIC50 501.19 nM
CN(C)Cc1ccc(-c2cc(C#N)c(NCc3ccc(F)s3)n3cnnc23)cc1 CHEMBL4065278 IC50 510.0 nM
COc1ccccc1CN1C[C@H](c2cn(C)c3ccccc23)[C@@H](N(C)C)C1 CHEMBL4074159 Ki 600.0 nM
CN(C)[C@H]1CN([C@H]2COc3cccc(F)c32)C[C@@H]1c1cn(C)c2ccccc12 CHEMBL4099707 Ki 610.0 nM
CN(C)c1cc(N2CCc3ccccc3C2)ccn1 CHEMBL4064198 Ki 680.0 nM
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN(C)C(C)C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1)C(N)=O CHEMBL4171889 Kd 680.0 nM
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN(C)C(C)C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1)C(=O)O CHEMBL5270760 Kd 680.0 nM
O=C(Nc1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12)c1cccnc1 CHEMBL4875413 IC50 710.0 nM
CN(C)Cc1ccc(C(=O)Nc2cnc(NCc3c(F)ccc4c3CCO4)n3cnnc23)cc1 CHEMBL4847603 IC50 720.0 nM
CN(C)Cc1ccc(-c2cnc(NCc3ccon3)n3cnnc23)cc1 CHEMBL4078858 IC50 770.0 nM
CN(c1cn(C)cn1)c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4846581 pIC50 794.33 nM
COc1cccc(C[C@H]2C[C@H]3Cc4c(cccc4OC)C[C@@H]3N(C)C2)c1 CHEMBL4097892 IC50 890.0 nM
Cc1nc(NCc2c(F)ccc3c2CCO3)sc1-c1ccnn1C CHEMBL5187105 Kd 900.0 nM
c1ccc2c(c1)CCN(c1ccncc1)C2 CHEMBL51594 Ki 950.0 nM
Fc1ccc2c(c1CNc1ncc(Nc3ccccc3)c3nncn13)CCO2 CHEMBL4859046 IC50 990.0 nM
N#Cc1ccc2nncn2c1NCc1ccco1 CHEMBL4063655 IC50 1000.0 nM
Nc1ncc2n1CC(Cc1cccc3c1OCO3)CC2 CHEMBL4066475 IC50 1000.0 nM
CN(C(=O)c1ccccc1)c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 CHEMBL4877072 IC50 1000.0 nM