N#Cc1cnc(-c2nc(CC(=O)N3CCC3)cs2)c(O)c1 CHEMBL3115315 IC50 0.0 nM
O=C(O)CNC(=O)c1nc(Cl)c2c(sc3ccccc32)c1O CHEMBL2436937 IC50 0.0 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4C)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043325 IC50 0.2 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(-c4ccn[nH]4)cc3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2041169 IC50 0.2 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc4scnc4c3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2041175 IC50 0.2 nM
Cc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4C)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041182 IC50 0.2 nM
Cc1nccc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4C)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)n1 CHEMBL2041184 IC50 0.2 nM
COc1nccnc1N1C(=O)N(c2ccc(-c3ccc(C(=O)O)cc3C)cc2)C(=O)C12CCN(Cc1ncccc1C)CC2 CHEMBL2041185 IC50 0.2 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3nccnc3C)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 CHEMBL2041186 IC50 0.2 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3cnccn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 CHEMBL2041190 IC50 0.2 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(C(=O)O)cc3)cc1)C(=O)N2c1ccncn1 CHEMBL2041192 IC50 0.2 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3ccncn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 CHEMBL2041193 IC50 0.2 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccccc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3C(=O)O)ncn1 CHEMBL2043010 IC50 0.4 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043168 IC50 0.4 nM
COc1cc(N2C(=O)N(c3ccc(-c4cccc(C(=O)O)c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043169 IC50 0.4 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4F)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043324 IC50 0.4 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3ncccn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 CHEMBL2041188 IC50 0.4 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(C(=O)O)cc3)cc1)C(=O)N2c1cnccn1 CHEMBL2041189 IC50 0.4 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)c(C)c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043326 IC50 0.5 nM
CNC(=O)c1ccc(-c2ccc(N3C(=O)N(c4cc(OC)ncn4)C4(CCN(Cc5ncccc5C)CC4)C3=O)cc2)cc1 CHEMBL2041178 IC50 0.5 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3cc(C(F)(F)F)ncn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 CHEMBL2041183 IC50 0.5 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)c1ccccc12 CHEMBL2042853 pIC50 0.5012 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)s4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041010 IC50 0.6 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(N4CCOCC4)cc3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2041170 IC50 0.6 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3cc(O)ncn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cn1 CHEMBL2040854 IC50 0.6 nM
O=C(O)CCNC(=O)c1cc(O)c(C(=O)NC(c2ccccc2)c2ccccc2)cn1 CHEMBL4167582 IC50 0.62 nM
O=C(O)CNC(=O)c1c(O)c2cc(Cl)cnc2n(Cc2ccc(C(F)(F)F)nc2)c1=O CHEMBL3115307 IC50 0.65 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)c1ccc(C(=O)O)cc12 CHEMBL2042993 IC50 0.7 nM
Cc1cccc(CN2CCC3(CC2)C(=O)N(c2ccc(-c4ccccc4)cc2)c2ccc(C(=O)O)cc23)n1 CHEMBL3115276 IC50 0.7 nM
O=C(Cc1ccc2ccccc2c1)Nc1cnc(-n2cccn2)nc1O CHEMBL3115311 IC50 0.7 nM
O=C(Cc1ccc(-c2ccccc2)cc1)Nc1cnc(-n2cccn2)nc1O CHEMBL4171446 IC50 0.7 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4Cl)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043171 IC50 0.8 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(N)=O)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041177 IC50 0.8 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(C(=O)O)cc3)cc1)C(=O)N2c1ncccn1 CHEMBL2041187 IC50 0.8 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3ccncn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cn1 CHEMBL2041194 IC50 0.8 nM
Cc1nc(C)c(-c2ccc(N3C(=O)N(c4cc(O)ncn4)C4(CCN(Cc5ncccc5C)CC4)C3=O)cc2)s1 CHEMBL2040897 IC50 0.9 nM
N#Cc1cc2c3c(c1)c(O)c(C(=O)NCC(=O)O)c(=O)n3CC(c1ccc(C(F)(F)F)cc1)O2 CHEMBL4161223 IC50 0.9 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)c(Cl)c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043172 IC50 1.0 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3cnccn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cn1 CHEMBL2041191 IC50 1.0 nM
Cc1cc(CCC(=O)O)cnc1CN1CCC2(CC1)CCN(c1ccc(-c3ccccc3)cc1)C2=O CHEMBL2443222 pIC50 1.0 nM
N#Cc1cc2c3c(c1)c(O)c(C(=O)NCC(=O)O)c(=O)n3CC(c1ccc(C(F)(F)F)cc1)N2 CHEMBL4170335 IC50 1.0 nM
COc1ccc(C(NC(=O)c2cnc(-c3cccnn3)nc2O)c2ccc(OC)cc2)cc1 CHEMBL4783524 IC50 1.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(C(=O)O)cc3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2043011 IC50 1.1 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(-c5cc(=O)[nH][nH]5)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041171 IC50 1.1 nM
COc1ccc(C(NC(=O)c2cnc(-n3cccn3)nc2O)c2ccc(OC)cc2)cc1 CHEMBL4785918 IC50 1.1 nM
O=C(NCc1ccc(-c2ccccc2)cc1)c1cnc(-n2cccn2)nc1O CHEMBL4796629 IC50 1.3 nM
COc1ccc([C@H](C)NC(=O)c2cnc(-n3cccn3)nc2O)cc1 CHEMBL4781541 IC50 1.4 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc5nc[nH]c5c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041174 IC50 1.5 nM
Cn1c(=O)c(C(=O)NCC(=O)O)c(O)c2cnc(-c3ccccc3F)nc21 CHEMBL3115302 IC50 1.5 nM
N#Cc1cc2c3c(c1)c(O)c(C(=O)NCC(=O)O)c(=O)n3CC(c1ccc(C(F)(F)F)cc1)S2 CHEMBL4162417 IC50 1.5 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)c1ncccc12 CHEMBL2042995 IC50 1.6 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C#N)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041176 IC50 1.6 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4)nc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041180 IC50 1.6 nM
N#Cc1cc2c3c(c1)c(O)c(C(=O)NCC(=O)O)c(=O)n3CCO2 CHEMBL4165865 IC50 1.8 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4C)nc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041181 IC50 1.9 nM
C#Cc1cnc(C(=O)NCC(=O)O)c(O)c1 CHEMBL4127286 IC50 1.9 nM
N#Cc1cc2c3c(c1)c(O)c(C(=O)NCC(=O)O)c(=O)n3CC(c1ccc(C(F)(F)F)cc1)C2 CHEMBL4159227 IC50 1.9 nM
C[C@H](NC(=O)c1cnc(-n2cccn2)nc1O)c1ccc(F)cc1 CHEMBL4793403 IC50 1.9 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc5cn[nH]c5c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041172 IC50 2.0 nM
N#Cc1ccc(C2Cn3c(=O)c(C(=O)NCC(=O)O)c(O)c4cc(OC(F)(F)F)cc(c43)O2)cc1 CHEMBL4451025 IC50 2.0 nM
O=C(NC(c1ccccc1)c1ccccc1)c1cnc(-n2cccn2)nc1O CHEMBL4799940 IC50 2.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)c1cccnc12 CHEMBL2042994 IC50 2.1 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1ncccn1 CHEMBL2043005 IC50 2.1 nM
CC(C)(NC(=O)c1cnc(-n2cc(C(=O)O)cn2)nc1O)c1ccccc1 CHEMBL4798217 IC50 2.1 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc5[nH]ncc5c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041173 IC50 2.3 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(Cl)cc3)c1=O)COC2 CHEMBL4462855 IC50 2.3 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2043004 IC50 2.5 nM
O=C(NC(c1ccccc1)c1ccccc1)c1cnc(-c2cccnn2)nc1O CHEMBL4782037 IC50 2.5 nM
Cc1cc(CC(=O)O)cnc1CN1CCC2(CC1)CCN(c1ccc(-c3ccccc3)cc1)C2=O CHEMBL2443221 pIC50 2.512 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(F)cc3F)c1=O)COC2 CHEMBL4529447 IC50 2.6 nM
COc1cc(N2C(=O)N(c3ccc(-c4csc(C(=O)O)c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041164 IC50 2.8 nM
O=C(NCc1ccc(Cl)cc1)c1cnc(-n2cccn2)nc1O CHEMBL4778991 IC50 2.9 nM
CC(C)(C)c1ccc(CS(=O)(=O)CC(=O)/N=c2/scc(CC(=O)O)n2O)cc1 CHEMBL520935 IC50 3.0 nM
O=C(O)CNC(=O)c1nc(-c2ccccc2)cc2c1ncn2-c1ccccc1 CHEMBL522419 IC50 3.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1nccc(O)n1 CHEMBL2043002 IC50 3.0 nM
O=C(O)CNC(=O)C1=C(O)c2ccccc2C1=O CHEMBL3115305 IC50 3.0 nM
Cn1c(=O)c(C(=O)NCC(=O)O)c(O)c2sccc21 CHEMBL3115300 IC50 3.0 nM
CC(C)(C)OC(=O)c1ccc(-n2[nH]cc(-n3ccnn3)c2=O)nc1 CHEMBL3646117 IC50 3.0 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(OC(F)(F)F)cc3)c1=O)COC2 CHEMBL4561977 IC50 3.1 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1ccnc(O)n1 CHEMBL2043007 IC50 3.4 nM
CC(C)(NC(=O)c1cnc(-n2cccn2)nc1O)c1ccccc1 CHEMBL4788580 IC50 3.7 nM
Cc1cccnc1CN1CCC2(CC1)CC(=O)N(c1ccc(-c3ccccc3)cc1)C2=O CHEMBL2042996 IC50 3.8 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccn(-c4ccccc4)n3)c1=O)COC2 CHEMBL4476576 IC50 3.8 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3cnc(O)nc3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2041167 IC50 3.9 nM
Cc1cc(-c2ccccc2)ccc1N1CCC2(CCN(Cc3ncccc3C)CC2)C1=O CHEMBL2443211 pIC50 3.981 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3cnc(C(F)(F)F)s3)c1=O)COC2 CHEMBL4590677 IC50 4.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)c1ccc(C#N)cc12 CHEMBL2042992 IC50 4.1 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1ccc(O)nn1 CHEMBL2043008 IC50 4.1 nM
O=C(O)CNC(=O)c1c(O)c2c(n(-c3ccc(-c4cccc(OC(F)(F)F)c4)cc3)c1=O)CSC2 CHEMBL4164978 IC50 4.1 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3nc4ccccc4o3)c1=O)COC2 CHEMBL4474474 IC50 4.2 nM
O=C(O)CNC(=O)c1c(O)c2cccc3c2n(c1=O)C(c1cncs1)CO3 CHEMBL4443606 IC50 4.2 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1cccc(O)n1 CHEMBL2043003 IC50 4.3 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1cc(O)ccn1 CHEMBL2043006 IC50 4.3 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3nc(C(F)(F)F)cs3)c1=O)COC2 CHEMBL4452138 IC50 4.3 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3cc(F)c(F)cc3F)c1=O)COC2 CHEMBL4462741 IC50 4.4 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)N(C)C)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041179 IC50 4.7 nM
O=C(O)CNC(=O)c1c(O)c2ccc(Cl)cc2n(Cc2ccc(C(F)(F)F)cc2)c1=O CHEMBL4564341 IC50 4.8 nM
COc1cc(N2C(=O)N(c3ccc(-c4coc(C(=O)O)c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041165 IC50 4.9 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3cnc(C(F)(F)F)cn3)c1=O)COC2 CHEMBL4567141 IC50 4.9 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)cc3)c1=O)COC2 CHEMBL4577928 IC50 4.9 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccccc4C(=O)O)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043170 IC50 5.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(C3CCCCC3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2043327 IC50 5.0 nM
C[C@H](NC(=O)c1cnc(-n2cccn2)nc1O)c1ccccc1 CHEMBL4796462 IC50 5.0 nM
Cc1cccnc1CN1CCC2(CC1)CCN(c1ccc(-c3ccc(C(=O)O)cc3)cc1)C2=O CHEMBL2443114 pIC50 5.012 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)nc3)c1=O)COC2 CHEMBL4458708 IC50 5.3 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(-c5ccn[nH]5)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041168 IC50 5.4 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3nc4ccccc4s3)c1=O)CCOC2 CHEMBL4162309 IC50 5.4 nM
O=C(O)CNC(=O)c1c(O)c2cccc3c2n(c1=O)CC(c1ccc(C(F)(F)F)nc1)N3 CHEMBL4452218 IC50 5.4 nM
O=C(NCc1ccc(OC(F)(F)F)cc1)c1cnc(-n2cccn2)nc1O CHEMBL4780656 IC50 5.6 nM
O=C(O)CNC(=O)c1c(O)c2c(n(-c3ccc(C(F)(F)F)cc3)c1=O)COC2 CHEMBL4169558 IC50 5.8 nM
CC(C)(NC(=O)c1cnc(-c2cc(C(=O)O)ccn2)nc1O)c1ccccc1 CHEMBL4791127 IC50 6.0 nM
O=C(O)CNC(=O)c1c(O)c2cccc3c2n(c1=O)C(c1ccc(C(F)(F)F)nc1)CO3 CHEMBL4552680 IC50 6.1 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(S(=O)(=O)Cc3ccc(Cl)cc3)CC2)cc1O CHEMBL5179640 IC50 6.14 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(S(=O)(=O)Cc3ccc(F)cc3)CC2)cc1O CHEMBL5208542 IC50 6.31 nM
O=C(O)CNC(=O)c1c(O)c2cccc3c2n(c1=O)CC(c1ccc(C(F)(F)F)cc1)S3 CHEMBL4454844 IC50 6.5 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(S(=O)(=O)Cc3ccc(OC(F)(F)F)cc3)CC2)cc1O CHEMBL5193631 IC50 6.55 nM
Cn1ccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)c1ccccc12 CHEMBL2042852 IC50 6.8 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3cnc(C(F)(F)F)nc3)c1=O)COC2 CHEMBL4582737 IC50 6.8 nM
CC(C)(O)c1ccc(Cn2c3c(c(O)c(C(=O)NCC(=O)O)c2=O)COC3)cc1 CHEMBL4483401 IC50 6.9 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(S(=O)(=O)Cc3ccc(Br)cc3)CC2)cc1O CHEMBL5169606 IC50 6.95 nM
O=c1c(-n2ccnn2)c[nH]n1-c1cc(N2CCOCC2)ncn1 CHEMBL3646118 IC50 7.0 nM
CN1Cc2c(c(O)c(C(=O)NCC(=O)O)c(=O)n2Cc2ccc(Cl)cc2)CC1=O CHEMBL4177137 IC50 7.3 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3cccnc3)cc1)c1ccccc12 CHEMBL2042854 IC50 7.8 nM
COc1cc(-c2ccccc2)ccc1N1CCC2(CCN(Cc3ncccc3C)CC2)C1=O CHEMBL2443129 pIC50 7.943 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(S(=O)(=O)Cc3ccc(C(F)(F)F)cc3)CC2)cc1O CHEMBL5175552 IC50 7.97 nM
Cc1ccccc1-c1ccc2nc(-n3cc(C(=O)O)cn3)[nH]c(=O)c2c1 CHEMBL3115313 IC50 8.0 nM
C[C@@H](NC(=O)c1cnc(-n2cccn2)nc1O)c1ccccc1 CHEMBL4783361 IC50 8.1 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(Cl)cc3)c1=O)CCOC2 CHEMBL4471891 IC50 8.5 nM
Cc1cccnc1CN1CCC2(CC1)NC(=O)N(c1ccc(-c3ccccc3)cc1)C2=O CHEMBL2042999 IC50 8.9 nM
N#Cc1ccc(Cn2c3c(c(O)c(C(=O)NCC(=O)O)c2=O)COCC3)c(F)c1 CHEMBL4573825 IC50 9.0 nM
O=C(O)c1cnn(-c2nc3cnn(Cc4ccc(-c5ccccc5)cc4)c3c(=O)[nH]2)c1 CHEMBL4647424 IC50 9.0 nM
C[C@@H](c1ccc(Cl)c(Cl)c1)n1ncc2nc(-n3cc(C(=O)O)cn3)[nH]c(=O)c21 CHEMBL4642843 IC50 9.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccno3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2040896 IC50 9.3 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ncc(C(F)(F)F)cn3)c1=O)COC2 CHEMBL4516521 IC50 10.0 nM
C[C@@H](NC(=O)c1cnc(-n2cccn2)nc1O)c1ccc(F)cc1 CHEMBL4782641 IC50 10.0 nM
O=C(O)CNC(=O)c1cnc(NS(=O)(=O)Cc2ccccc2)nc1O CHEMBL5219134 EC50 10.0 nM
O=C(O)Cc1cs/c(=N/C(=O)CS(=O)(=O)Cc2ccccc2)n1O CHEMBL481692 IC50 11.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccn3)cc1)c1ccccc12 CHEMBL2042855 IC50 11.0 nM
COCc1nc(-c2ccc(N3C(=O)N(c4cc(O)ncn4)C4(CCN(Cc5ncccc5C)CC4)C3=O)cc2)no1 CHEMBL2040894 IC50 11.0 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)nc3)c1=O)CCOC2 CHEMBL4461978 IC50 11.0 nM
CCc1ccc2cc(CCn3ncc4nc(-n5cc(C(=O)O)cn5)nc(O)c43)ccc2c1 CHEMBL4170656 IC50 12.0 nM
O=C(O)c1cnn(-c2nc3cn(Cc4ccc(-c5ccccc5)cc4)nc3c(=O)[nH]2)c1 CHEMBL4645985 IC50 12.0 nM
CC(C)(NC(=O)c1cnc(-c2cccnn2)nc1O)c1ccccc1 CHEMBL4789540 IC50 12.0 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(Cl)cc3)nc2)C1=O CHEMBL3900684 IC50 13.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3cncnc3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2041166 IC50 14.0 nM
CC(C)c1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cn2)cc1 CHEMBL3978756 IC50 14.0 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(C4CC4)cc3)nc2)C1=O CHEMBL3938099 IC50 15.0 nM
CCCc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cn2)cc1 CHEMBL3927574 IC50 15.0 nM
O=C(O)CNC(=O)c1ncc(C#CCOc2ccc(Cl)cc2)cc1O CHEMBL4162752 IC50 15.62 nM
Cc1cccnc1CN1CCC2(CC1)CCN(c1ccc(-c3ccc(CC(=O)O)cc3)cc1)C2=O CHEMBL2443115 pIC50 15.85 nM
Cn1ccnc1CN1CCC2(CC1)CCN(c1ccc(-c3ccccc3)cc1)C2=O CHEMBL2443213 pIC50 15.85 nM
CC(C)(NC(=O)c1cnc(-c2cscn2)nc1O)c1ccccc1 CHEMBL4777567 IC50 16.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)c1ccc(Br)cc12 CHEMBL2042991 IC50 17.0 nM
O=C(O)CNC(=O)c1ncc(-c2ccc3ccccc3c2)cc1O CHEMBL2338326 IC50 17.0 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(S(=O)(=O)Cc3ccccc3)CC2)cc1O CHEMBL5169444 IC50 18.22 nM
Cc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cn2)cc1Cl CHEMBL3979667 IC50 19.0 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)cc3)c1=O)CCOC2 CHEMBL4582939 IC50 19.0 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)CNc3ccc(Cl)c(Cl)c3)CC2)cc1O CHEMBL5436949 IC50 19.62 nM
O=C(O)Cc1cs/c(=N\C(=O)CS(=O)(=O)Cc2ccc3ccccc3c2)n1O CHEMBL2312530 IC50 20.0 nM
O=C(O)c1cnn(-c2nc(O)c3c(cnn3C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)n2)c1 CHEMBL4161082 IC50 20.0 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)cc3)c1=O)COCC2 CHEMBL4469994 IC50 20.0 nM
N#Cc1ccc(S(=O)(=O)N2CC=C(c3cnc(C(=O)NCC(=O)O)c(O)c3)CC2)cc1 CHEMBL5181096 IC50 20.73 nM
O=C(O)Cc1cs/c(=N/C(=O)CS(=O)(=O)c2ccc(-c3ccccc3)cc2)n1O CHEMBL519615 IC50 21.0 nM
CC(C)(C)c1ccc(S(=O)(=O)CC(=O)/N=c2/scc(CC(=O)O)n2O)cc1 CHEMBL481875 IC50 21.0 nM
O=C(O)Cc1cs/c(=N\C(=O)S(=O)(=O)c2ccc3ccccc3c2)n1O CHEMBL570655 IC50 21.0 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2cnc(Oc3ccc(C4CC4)cc3)cn2)C1=O CHEMBL3919849 IC50 21.0 nM
O=C(O)CNC(=O)c1c(O)c2cccc3c2n(c1=O)CCO3 CHEMBL4165493 IC50 21.0 nM
CCc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cn2)cc1 CHEMBL3970474 IC50 22.0 nM
O=C(O)CNC(=O)c1c(O)c2ccccc2n(Cc2ccccc2)c1=O CHEMBL3186774 IC50 22.0 nM
O=C(O)CNC(=O)c1c(O)n(C2CCCCC2)c(=O)n(C2CCCCC2)c1=O CHEMBL4163812 IC50 22.2 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(S(=O)(=O)c3cccc4ccccc34)CC2)cc1O CHEMBL5197483 IC50 22.39 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)CNc3ccc(Cl)cc3)CC2)cc1O CHEMBL5394158 IC50 22.53 nM
O=C(O)CNC(=O)c1ncc(-c2cn(CCCc3ccc(Cl)cc3)nn2)cc1O CHEMBL4126434 IC50 22.73 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)cc3)c1=O)CCNC2 CHEMBL4169295 IC50 22.9 nM
O=C(O)c1cnn(-c2nc3scc(Cc4ccc(-c5ccccc5)cc4)c3c(=O)[nH]2)c1 CHEMBL4648388 IC50 23.0 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(C(F)(F)F)cc3)nc2)C1=O CHEMBL3938870 IC50 24.0 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(Cl)cc3)cc2)C1=O CHEMBL3927061 IC50 24.0 nM
O=C(O)c1cnn(-c2nc3cnn(Cc4ccc(Cl)c(Cl)c4)c3c(=O)[nH]2)c1 CHEMBL4643092 IC50 24.0 nM
Cc1nc(-c2ncc(C(=O)NC(C)(C)c3ccccc3)c(O)n2)cs1 CHEMBL4780077 IC50 24.0 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)CNc3ccc(F)cc3)CC2)cc1O CHEMBL5419909 IC50 24.32 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)c3ccc(OC(F)(F)F)cc3)CC2)cc1O CHEMBL5420139 IC50 24.63 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(C(=O)c3ccc(Cl)cc3)CC2)cc1O CHEMBL5193746 IC50 24.98 nM
Cc1cc(CN2CCC(O)=C(C(=O)NCC(=O)O)C2=O)cnc1Oc1ccc(Cl)cc1 CHEMBL3904398 IC50 25.0 nM
O=C(O)c1cnn(-c2nc3cnn(Cc4ccc(-c5ccccc5F)c(F)c4)c3c(=O)[nH]2)c1 CHEMBL4648359 IC50 25.0 nM
Cc1cccnc1CN1CCC2(CC1)CCN(c1ccc(-c3ccccc3)cc1F)C2=O CHEMBL2443112 pIC50 25.12 nM
Cc1cccnc1CN1CCC2(CC1)CCN(c1ccc(-c3ccccc3)cc1)C2=O CHEMBL2042997 pIC50 25.12 nM
Cc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cn2)cc1F CHEMBL3900866 IC50 26.0 nM
Cc1ccc(Oc2ncc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cc2Cl)cc1 CHEMBL3964845 IC50 26.0 nM
O=C(O)Cc1cs/c(=N/C(=O)CS(=O)(=O)c2ccc3ccccc3c2)n1O CHEMBL479415 IC50 27.0 nM
Cc1cccnc1CN1CCC2(NC(=O)N(c3ccc(-c4ccccc4)cc3)C2=O)C(C(=O)O)C1 CHEMBL2043000 IC50 27.0 nM
COc1ccc(C2COc3cccc4c(O)c(C(=O)NCC(=O)O)c(=O)n2c34)cc1 CHEMBL4473810 IC50 27.0 nM
Cc1nc(C(=O)NCC(=O)O)c(O)c2ccc(Oc3ccccc3)cc12 CHEMBL2338329 IC50 27.0 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(S(=O)(=O)c3ccc(Cl)cc3)CC2)cc1O CHEMBL5202258 IC50 27.03 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(C(=O)Nc3ccc(Cl)cc3)CC2)cc1O CHEMBL5201969 IC50 27.03 nM
CC(C)(NC(=O)c1cnc(-c2ccccn2)nc1O)c1ccccc1 CHEMBL4800385 IC50 28.0 nM
O=C(O)CNC(=O)c1ncc(-c2cccc(Cl)c2)cc1O CHEMBL3646221 IC50 29.0 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(S(=O)(=O)c3ccc(Br)cc3)CC2)cc1O CHEMBL5196612 IC50 29.69 nM
Cn1ccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-n3cccc3)nc1)c1ccccc12 CHEMBL2042849 IC50 30.0 nM
Cc1cccnc1CN1CCC2(CC1)CC(C(=O)O)N(c1ccc(-c3ccccc3)cc1)C2=O CHEMBL2042998 IC50 31.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(N3CCC3=O)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2043328 IC50 31.0 nM
COc1cc(N2CCC3(CCN(Cc4ncccc4C)CC3)C2=O)ccc1-c1ccccc1 CHEMBL2443130 pIC50 31.62 nM
Cc1ccc(Oc2ncc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cc2F)cc1 CHEMBL3929749 IC50 32.0 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)CNc3ccc(Cl)cc3Cl)CC2)cc1O CHEMBL5421805 IC50 32.45 nM
O=C(O)Cc1cs/c(=N/C(=O)CS(=O)(=O)c2ccc(Cl)cc2)n1O CHEMBL518140 IC50 33.0 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)c3ccc(Cl)cc3)CC2)cc1O CHEMBL5434005 IC50 34.45 nM
Cc1ccc(C(=O)N2CCC(c3cnc(C(=O)NCC(=O)O)c(O)c3)CC2)cc1 CHEMBL5437125 IC50 34.58 nM
Cc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cn2)cc1 CHEMBL3919156 IC50 39.0 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2cnc(Oc3ccc(Cl)cc3)cn2)C1=O CHEMBL3931950 IC50 39.0 nM
Cc1cccnc1CN1CCC2(CC1)CCN(c1ccc(-c3ccccc3)cc1C#N)C2=O CHEMBL2443113 pIC50 39.81 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)CNc3ccc(OC(F)(F)F)cc3)CC2)cc1O CHEMBL5399097 IC50 39.93 nM
N#Cc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cn2)cc1 CHEMBL3939973 IC50 40.0 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3cccc(Cl)c3)nc2)C1=O CHEMBL3934734 IC50 40.0 nM
Cc1cc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cn2)ccc1F CHEMBL3963116 IC50 41.0 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3cccc(C(F)(F)F)c3)nc2)C1=O CHEMBL3928117 IC50 43.0 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)CNc3ccc(C(F)(F)F)cc3)CC2)cc1O CHEMBL5404669 IC50 43.42 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(S(=O)(=O)c3ccc(F)cc3)CC2)cc1O CHEMBL5178385 IC50 43.49 nM
Cn1ccnc1CN1CCC2(CC1)C(=O)N(c1ccc3ccccc3c1)c1ccccc12 CHEMBL2042846 IC50 44.0 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)c3ccc(C(F)(F)F)cc3)CC2)cc1O CHEMBL5397478 IC50 44.25 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3cccc(OC(F)(F)F)c3)nc2)C1=O CHEMBL3971209 IC50 45.0 nM
Cc1ccc(S(=O)(=O)N2CC=C(c3cnc(C(=O)NCC(=O)O)c(O)c3)CC2)cc1 CHEMBL5180160 IC50 45.31 nM
Cn1c(=O)c(C(=O)NCC(=O)O)c(O)c2ccc(Br)cc21 CHEMBL3115299 IC50 46.0 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(S(=O)(=O)c3cccs3)CC2)cc1O CHEMBL5194580 IC50 46.47 nM
Cc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cc2)cc1C CHEMBL3935503 IC50 48.0 nM
Cc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cc2)cc1 CHEMBL3932706 IC50 49.0 nM
O=C1N(c2ccc(-c3ccccc3)cc2)C(=O)C2(CCN(Cc3ccccc3O)CC2)N1c1ncccn1 CHEMBL4536280 IC50 49.0 nM
Cc1ccc(S(=O)(=O)CC(=O)/N=c2/scc(CC(=O)O)n2O)cc1 CHEMBL481700 IC50 50.0 nM
O=C(O)c1cnn(-c2nc(N3CCCC3)c3cc(Oc4ccc(Cl)cc4)ccc3n2)c1 CHEMBL3115314 IC50 50.0 nM
O=C(O)CNC(=O)c1nc(Cl)c2cc(Oc3ccccc3)ccc2c1O CHEMBL4163070 IC50 50.0 nM
Cc1cccnc1CN1CCC2(CC1)CCN(c1ccc(-c3cccc(C(=O)O)c3)cc1)C2=O CHEMBL2443116 pIC50 50.12 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(S(=O)(=O)c3ccc(OC(F)(F)F)cc3)CC2)cc1O CHEMBL5170794 IC50 50.88 nM
O=C(O)c1cnn(-c2nc3ccn(Cc4ccc(-c5ccccc5)cc4)c3c(=O)[nH]2)c1 CHEMBL4647772 IC50 51.0 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(S(=O)(=O)c3cccnc3)CC2)cc1O CHEMBL5202103 IC50 51.19 nM
Cn1ccnc1CN1CCC2(CC1)C(=O)N(c1ccc(Oc3ccccc3)cc1)c1ccccc12 CHEMBL2042851 IC50 52.0 nM
O=C(O)CNC(=O)c1ncc(-c2cn(CCc3ccc(Cl)cc3)nn2)cc1O CHEMBL4129555 IC50 52.84 nM
Cc1ccc(Oc2cnc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cn2)cc1 CHEMBL3908337 IC50 54.0 nM
C[C@@H](c1cc(Cl)ccc1Cl)n1ncc2nc(-n3cc(C(=O)O)cn3)[nH]c(=O)c21 CHEMBL4646935 IC50 54.0 nM
COc1ccc(C(=O)N2CCC(c3cnc(C(=O)NCC(=O)O)c(O)c3)CC2)cc1 CHEMBL5433080 IC50 54.08 nM
COc1ccnc(N2C(=O)N(c3ccc(-c4ccccc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)n1 CHEMBL4535543 IC50 55.0 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(C(F)(F)F)nc3)cc2)C1=O CHEMBL3950233 IC50 56.0 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(C4CC4)cn3)cc2)C1=O CHEMBL3941455 IC50 56.0 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)CNc3ccccc3)CC2)cc1O CHEMBL5419325 IC50 56.79 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)c3cccs3)CC2)cc1O CHEMBL5403753 IC50 57.65 nM
O=C(O)CNC(=O)c1nc(Br)c2cc(Oc3ccccc3)ccc2c1O CHEMBL5209093 IC50 57.8 nM
Cc1ccc(Oc2ccc(CN3C(=O)C(C(=O)NCC(=O)O)=C(O)CC3(C)C)cn2)cc1 CHEMBL3921843 IC50 59.0 nM
N#Cc1nc(C(=O)NCC(=O)O)c(O)c2cc(-c3ccccc3)c(=O)n(Cc3ccccc3)c12 CHEMBL3671877 IC50 60.0 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(C(F)(F)F)cc3)cn2)C1=O CHEMBL3971556 IC50 60.0 nM
C[C@H](c1ccc(Cl)c(Cl)c1)n1ncc2nc(-n3cc(C(=O)O)cn3)[nH]c(=O)c21 CHEMBL4638332 IC50 60.0 nM
COc1cccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cc2)c1 CHEMBL3899803 IC50 61.0 nM
COc1cccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cn2)c1 CHEMBL3919494 IC50 61.0 nM
O=C(NCc1ccc2c(c1)CCO2)c1ccc(-c2ncn[nH]2)nc1 CHEMBL4173319 IC50 61.0 nM
CC(c1ccc(Cl)cc1)n1cc(-c2cnc(C(=O)NCC(=O)O)c(O)c2)nn1 CHEMBL4125856 IC50 61.08 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3cccc(F)c3)cc2)C1=O CHEMBL3965289 IC50 63.0 nM
Cc1ccccc1Oc1ccc(CN2CCC(O)=C(C(=O)NCC(=O)O)C2=O)cc1 CHEMBL3940655 IC50 63.0 nM
Cn1ccnc1CN1CCC2(CC1)NC(=O)N(c1ccc(-c3ccccc3)cc1)C2=O CHEMBL4482885 IC50 63.0 nM
Cc1ccc(NCC(=O)N2CCC(c3cnc(C(=O)NCC(=O)O)c(O)c3)CC2)cc1 CHEMBL5419740 IC50 64.54 nM
Cn1c(=O)c(C(=O)CCC(=O)O)c(O)c2ccc(Br)cc21 CHEMBL3115306 IC50 65.0 nM
O=C(O)CNC(=O)c1nc(Cl)cc2c1ncn2-c1ccccc1 CHEMBL448608 IC50 66.0 nM
Cc1cccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cn2)c1 CHEMBL3964973 IC50 66.0 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3cccc(F)c3)nc2)C1=O CHEMBL3915801 IC50 66.0 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)cc3)c1=O)CCCC2 CHEMBL4172984 IC50 66.0 nM
O=C(O)CNC(=O)C1C(=O)N(C2CCCCC2)C(=O)N(C2CCCCC2)C1=O CHEMBL3544988 IC50 67.0 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)c3ccc(F)cc3)CC2)cc1O CHEMBL5405247 IC50 67.45 nM
O=C(O)CNC(=O)c1ncc(-c2cn(CCCOc3ccc(Cl)cc3)nn2)cc1O CHEMBL4128320 IC50 67.58 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(Cl)cn3)cc2)C1=O CHEMBL3965153 IC50 68.0 nM
Cc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)nc2)cc1 CHEMBL3942899 IC50 69.0 nM
Cc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(=O)[O-])C3=O)nc2)cc1 CHEMBL4129773 IC50 69.0 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)c3ccccc3)CC2)cc1O CHEMBL5405997 IC50 69.7 nM
O=C(O)CNC(=O)c1nc(Cl)c2ccccc2c1O CHEMBL426560 IC50 70.0 nM
O=C1N(c2ccc(-c3ccccc3)cc2)C(=O)C2(CCN(Cc3ncc[nH]3)CC2)N1c1ncccn1 CHEMBL4557378 IC50 70.0 nM
Cc1ccccc1OCC#Cc1cnc(C(=O)NCC(=O)O)c(O)c1 CHEMBL4795349 IC50 70.4 nM
O=C(O)Cc1cs/c(=N/C(=O)CS(=O)(=O)c2ccccc2)n1O CHEMBL517834 IC50 72.0 nM
O=C(O)Cc1cs/c(=N/C(=O)CS(=O)(=O)c2ccccc2Cl)n1O CHEMBL480159 IC50 72.0 nM
Cc1ccc(Oc2ncc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cn2)cc1 CHEMBL3965870 IC50 72.0 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(S(=O)(=O)c3ccc(C(F)(F)F)cc3)CC2)cc1O CHEMBL5181654 IC50 72.28 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(Cc3ccc(Cl)cc3)CC2)cc1O CHEMBL5207133 IC50 73.93 nM
Cc1cccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cc2)c1 CHEMBL3941163 IC50 75.0 nM
CCC(c1ccc(Cl)cc1)n1cc(-c2cnc(C(=O)NCC(=O)O)c(O)c2)nn1 CHEMBL4127232 IC50 75.82 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-n3cccn3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2040895 IC50 76.0 nM
N#Cc1ccc(C(=O)N2CCC(c3cnc(C(=O)NCC(=O)O)c(O)c3)CC2)cc1 CHEMBL5414229 IC50 76.48 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccccc3F)cc2)C1=O CHEMBL3896281 IC50 77.0 nM
O=C(O)CNC(=O)c1ncc(-c2cn(CCOc3ccc(Cl)cc3)nn2)cc1O CHEMBL4126256 IC50 77.0 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)c3cccc(F)c3)CC2)cc1O CHEMBL5398964 IC50 77.09 nM
O=C(O)c1cnn(-c2nc3scc(Cc4ccccc4)c3c(=O)[nH]2)c1 CHEMBL4649343 IC50 78.0 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(C(F)(F)F)cn3)cc2)C1=O CHEMBL3899583 IC50 79.0 nM
O=C(O)c1cnn(-c2nc3cc(Cl)c(F)cc3[nH]2)c1 CHEMBL1229508 pIC50 79.43 nM
O=C(O)c1cnn(-c2nc3cc(C(F)(F)F)c(Cl)cc3[nH]2)c1 CHEMBL1688407 pIC50 79.43 nM
Cc1cc(CCCC(=O)O)cnc1CN1CCC2(CC1)CCN(c1ccc(-c3ccccc3)cc1)C2=O CHEMBL2443118 pIC50 79.43 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(S(=O)(=O)c3ccccc3F)CC2)cc1O CHEMBL5200064 IC50 82.83 nM
O=C(O)CNC(=O)c1ncc(C#CCOCc2ccc(Cl)cc2)cc1O CHEMBL4776330 IC50 84.3 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(F)cc3)nc2)C1=O CHEMBL3962783 IC50 87.0 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccccc3)cc2)C1=O CHEMBL3982980 IC50 88.0 nM
Cc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cc2)nc1 CHEMBL3900473 IC50 89.0 nM
Cc1cc2c(O)c(C(=O)NCC(=O)O)nc(C#N)c2n(Cc2ccccc2)c1=O CHEMBL3671869 IC50 90.0 nM
N#Cc1nc(C(=O)NCC(=O)O)c(O)c2cc(Cc3ccccc3)c(=O)n(Cc3ccccc3)c12 CHEMBL3671880 IC50 90.0 nM
Cc1ccc(Oc2ncc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cc2C)cn1 CHEMBL3910688 IC50 92.0 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)c3ccccc3F)CC2)cc1O CHEMBL5411765 IC50 92.72 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccccc3)nc2)C1=O CHEMBL3946959 IC50 94.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1cc(C(=O)O)ccn1 CHEMBL4526672 IC50 94.0 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(F)cc3)cn2)C1=O CHEMBL3939585 IC50 96.0 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(S(=O)(=O)c3ccc4ccccc4c3)CC2)cc1O CHEMBL5202382 IC50 97.38 nM
O=C(O)Cc1cs/c(=N/C(=O)CS(=O)(=O)c2cccc(Cl)c2)n1O CHEMBL480160 IC50 98.0 nM
O=C(O)CNC(=O)c1ncc(C2CCN(S(=O)(=O)Cc3ccc(C(F)(F)F)cc3)CC2)cc1O CHEMBL5437473 IC50 98.9 nM
[C-]#[N+]c1ccc(-c2cnc(C(=O)NCC(=O)O)c(O)c2)cc1 CHEMBL3646219 IC50 99.0 nM
Cc1ccccc1Oc1ccc(CN2CCC(O)=C(C(=O)NCC(=O)O)C2=O)cn1 CHEMBL3949430 IC50 99.0 nM
O=C(O)c1cnn(-c2nc3cc(C(F)(F)F)c(F)cc3[nH]2)c1 CHEMBL1688408 pIC50 100.0 nM
O=C(O)CNC(=O)c1c(O)cc(-c2cc(F)cc(Cl)c2)c2ncnn12 CHEMBL3115316 IC50 100.0 nM
O=C(O)c1cnn(-c2nc3cc(OC(F)(F)F)c(Cl)cc3[nH]2)c1 CHEMBL3115312 IC50 100.0 nM
N#Cc1nc(C(=O)NCC(=O)O)c(O)c2ccn(Cc3ccccc3)c(=O)c12 CHEMBL3671909 IC50 100.0 nM
O=C(O)CNC(=O)c1cnc(NS(=O)(=O)c2ccc(-c3ccccc3)cc2)nc1O CHEMBL5219277 EC50 100.0 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccccc3F)nc2)C1=O CHEMBL3944263 IC50 108.0 nM
O=C(O)CNC(=O)c1c(O)cc(-c2cccc(Cl)c2)c2ncnn12 CHEMBL4159751 IC50 110.0 nM
Cc1ccc(OCC#Cc2cnc(C(=O)NCC(=O)O)c(O)c2)cc1 CHEMBL4754277 IC50 110.0 nM
O=C(NCc1ccc(F)cc1)c1cnc(-c2ccccn2)nc1O CHEMBL4794308 IC50 110.0 nM
Cc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)cc2)cn1 CHEMBL3945999 IC50 112.0 nM
O=C(O)CNC(=O)c1c(O)cc(-c2cccc(Cl)c2)n2ncnc12 CHEMBL4174643 IC50 120.0 nM
Cc1cccc(OCC#Cc2cnc(C(=O)NCC(=O)O)c(O)c2)c1 CHEMBL4756482 IC50 125.0 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)c3ccccc3Cl)CC2)cc1O CHEMBL5410556 IC50 130.8 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(S(=O)(=O)c3ccccc3)CC2)cc1O CHEMBL5189154 IC50 131.9 nM
Cc1ccc(N2C(=O)C3(CCN(Cc4nccn4C)CC3)c3ccccc32)cc1C CHEMBL2042850 IC50 140.0 nM
O=C(O)c1cnn(-c2nc3scc(CC4CCCCC4)c3c(=O)[nH]2)c1 CHEMBL4638096 IC50 140.0 nM
O=C(O)CNC(=O)c1ncc(C2=CCN(S(=O)(=O)c3cccc(F)c3)CC2)cc1O CHEMBL5180680 IC50 140.8 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)c3ccc(Cl)cc3Cl)CC2)cc1O CHEMBL5404727 IC50 143.8 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(F)cn3)cc2)C1=O CHEMBL3909235 IC50 146.0 nM
O=C(NCC1CC1)c1cnc(-n2cccn2)nc1O CHEMBL4784668 IC50 150.0 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)c3ccccn3)CC2)cc1O CHEMBL5398272 IC50 158.0 nM
O=C(O)c1cnn(-c2nc3cc(OC(F)(F)F)cc(Br)c3[nH]2)c1 CHEMBL1688406 pIC50 158.49 nM
O=C1N(c2ccc(-c3ccccc3)cc2)CCC12CCN(Cc1ccccn1)CC2 CHEMBL2443217 pIC50 158.49 nM
O=C(O)CNC(=O)c1ncc(C#CCOc2ccccc2)cc1O CHEMBL4755522 IC50 169.0 nM
O=C(O)CNC(=O)c1ncc(C#CCOc2ccccc2Cl)cc1O CHEMBL4760023 IC50 175.0 nM
O=C(O)CCNC(=O)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O CHEMBL3671889 IC50 180.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1cnc3ccccc3c1)c1ccccc12 CHEMBL2042843 IC50 185.0 nM
COc1ccc(OCC#Cc2cnc(C(=O)NCC(=O)O)c(O)c2)cc1 CHEMBL4747660 IC50 186.0 nM
O=C(O)CNC(=O)c1ncc(C#CCOc2ccc(F)cc2)cc1O CHEMBL4763404 IC50 186.0 nM
N#Cc1ccccc1-c1ccc(COCc2ccc(-n3cc(C(=O)O)cn3)nc2)cc1 CHEMBL222115 IC50 190.0 nM
[C-]#[N+]c1cccc(-c2cnc(C(=O)NCC(=O)O)c(O)c2)c1 CHEMBL3646230 IC50 190.0 nM
O=C(NCc1ccncc1)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O CHEMBL3671893 IC50 190.0 nM
O=C(O)CNC(=O)c1c(O)cc(-c2ccccc2)c2ncnn12 CHEMBL4173606 IC50 190.0 nM
COc1ccc(S(=O)(=O)Nc2ncc(C(=O)NCC(=O)O)c(O)n2)cc1 CHEMBL5218673 EC50 190.0 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)c3cccc(Cl)c3)CC2)cc1O CHEMBL5420134 IC50 194.9 nM
O=C1N(c2ccc(-c3ccccc3)cc2)CCC12CCN(Cc1ncccc1Cl)CC2 CHEMBL2443218 pIC50 199.53 nM
O=C(O)CNC(=O)c1nc(-c2cccnc2)c2c(cc(-c3ccccc3)c(=O)n2Cc2ccccc2)c1O CHEMBL3671879 IC50 210.0 nM
O=C(O)CNC(=O)c1c(O)cc(-c2ccccc2)n2ncnc12 CHEMBL4175056 IC50 210.0 nM
Cn1ccc(-c2ncc(C(=O)NC(C)(C)c3ccccc3)c(O)n2)n1 CHEMBL4786322 IC50 210.0 nM
COc1ccccc1OCC#Cc1cnc(C(=O)NCC(=O)O)c(O)c1 CHEMBL4760527 IC50 218.0 nM
O=C(O)CNC(=O)c1ncc2c(ccc(=O)n2Cc2ccccc2)c1O CHEMBL3671870 IC50 220.0 nM
N#Cc1nc(C(=O)NCC(=O)O)c(O)c2c1N(Cc1ccccc1)C(=O)CC2 CHEMBL3671872 IC50 220.0 nM
O=C(O)CNC(=O)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O CHEMBL3671888 IC50 220.0 nM
O=C(O)CNC(=O)c1c(O)cc(CCc2ccccc2)n2ncnc12 CHEMBL4166742 IC50 220.0 nM
O=C(O)CNC(=O)c1ncc(-c2cn(Cc3ccc(Cl)cc3)nn2)cc1O CHEMBL4129725 IC50 228.2 nM
O=C(O)CNC(=O)c1ncc2c(cc(Cc3ccccc3)c(=O)n2Cc2ccccc2)c1O CHEMBL3671866 IC50 230.0 nM
Cc1nc(C(=O)NCC(=O)O)c(O)c2cc(-c3ccccc3)c(=O)n(Cc3ccccc3)c12 CHEMBL3671875 IC50 230.0 nM
COc1ccc(Cn2ccc3c(O)c(C(=O)NCCC(=O)O)ncc3c2=O)c(OC)c1 CHEMBL3671927 IC50 230.0 nM
O=C(O)CNC(=O)c1ncc(-c2cn(Cc3cc(Cl)cc(Cl)c3)nn2)cc1O CHEMBL4129832 IC50 231.1 nM
O=C(O)CNC(=O)c1ncc(-c2ccc(Cl)cc2)cc1O CHEMBL3646220 IC50 240.0 nM
O=C(O)CNC(=O)c1ncc(-c2cn(Cc3ccc(Cl)c(Cl)c3)nn2)cc1O CHEMBL4128470 IC50 248.0 nM
O=C(O)CNC(=O)c1ncc(C#CCOc2cccc(F)c2)cc1O CHEMBL4760608 IC50 256.0 nM
O=C(O)CNC(=O)c1ncc(C2CCN(C(=O)c3cc(F)cc(F)c3)CC2)cc1O CHEMBL5435363 IC50 256.5 nM
O=C(O)CNC(=O)c1ncc2c(cc(-c3ccccc3)c(=O)n2Cc2ccccc2)c1O CHEMBL3671867 IC50 260.0 nM
N#Cc1ccc(OCC#Cc2cnc(C(=O)NCC(=O)O)c(O)c2)cc1 CHEMBL4746856 IC50 263.0 nM
O=C(O)CNC(=O)c1ncc(-c2cn(Cc3ccc(Cl)cc3Cl)nn2)cc1O CHEMBL4128884 IC50 271.0 nM
Cc1ccc(Cn2cc(-c3cnc(C(=O)NCC(=O)O)c(O)c3)nn2)cc1C CHEMBL4126407 IC50 278.3 nM
[O-]c1c(-n2ccnn2)cnn1-c1cc(N2CCOCC2)ncn1 CHEMBL3931782 IC50 280.0 nM
COc1ccc(Cn2ccc3c(O)c(C(=O)NCC(=O)O)ncc3c2=O)c(OC)c1 CHEMBL3671926 IC50 280.0 nM
COc1ccc(Cn2cc(-c3cnc(C(=O)NCC(=O)O)c(O)c3)nn2)cc1 CHEMBL4129500 IC50 280.6 nM
O=C(O)CNC(=O)c1nccc2c1ncn2-c1ccccc1 CHEMBL522970 IC50 290.0 nM
O=C(NCc1nnn[nH]1)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O CHEMBL3671948 IC50 290.0 nM
O=C(O)CNC(=O)c1c(O)cc(CCc2ccc(F)cc2)n2ncnc12 CHEMBL4171201 IC50 290.0 nM
Cc1csc2nc(-n3cc(C(=O)O)cn3)[nH]c(=O)c12 CHEMBL4644023 IC50 290.0 nM
O=C(O)CNC(=O)c1ncc(-c2ccc(F)cc2)cc1O CHEMBL3646224 IC50 300.0 nM
O=C(O)CNC(=O)c1ncc(-c2cccc(C(=O)N3CCCC3)c2)cc1O CHEMBL3646233 IC50 300.0 nM
O=C(O)CNC(=O)c1nc(-c2ccccc2)c2c(cc(-c3ccccc3)c(=O)n2Cc2ccccc2)c1O CHEMBL3671876 IC50 300.0 nM
O=C(O)CNC(=O)c1ncc(-c2cn(Cc3ccc(Br)cc3)nn2)cc1O CHEMBL4126047 IC50 308.3 nM
O=C(O)c1cnn(-c2nc3cc(OC(F)(F)F)ccc3[nH]2)c1 CHEMBL1688405 pIC50 316.23 nM
O=C(O)CNC(=O)c1nccc2c1ncn2Cc1ccccc1 CHEMBL521790 IC50 320.0 nM
COc1ccc(CN2CCc3c(cnc(C(=O)NCCC(=O)O)c3O)C2=O)c(OC)c1 CHEMBL3671930 IC50 320.0 nM
O=C(O)CNC(=O)c1ncc(C#CCNc2ccccc2)cc1O CHEMBL4756775 IC50 326.0 nM
O=C(O)CNC(=O)c1nccc2c1ncn2-c1ccc(Br)cc1 CHEMBL491424 IC50 330.0 nM
O=C(O)CNC(=O)c1ncc(C#CCOc2cccc3ccccc23)cc1O CHEMBL4789825 IC50 346.0 nM
O=C(O)CNC(=O)c1nc(-c2cncc(F)c2)c2c(=O)n(Cc3ccccc3)ccc2c1O CHEMBL3671907 IC50 350.0 nM
CN(C=O)CCNC(=O)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O CHEMBL3671976 IC50 350.0 nM
Cn1ccnc1CN1CCC2(CC1)C(=O)N(c1cnc3ccccc3c1)c1ccccc12 CHEMBL2042133 IC50 370.0 nM
O=C(O)CNC(=O)c1c(O)cc(CCc2ccccc2)c2ncnn12 CHEMBL4167657 IC50 370.0 nM
O=C(O)CNC(=O)c1ncc(-c2cn(Cc3ccc(F)cc3)nn2)cc1O CHEMBL4126204 IC50 375.4 nM
CCc1ccc(OCC#Cc2cnc(C(=O)NCC(=O)O)c(O)c2)cc1 CHEMBL4749938 IC50 378.0 nM
O=C(NC1CC1)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O CHEMBL3671899 IC50 390.0 nM
CC(C)(NC(=O)c1cnc(-c2ncccn2)nc1O)c1ccccc1 CHEMBL4792941 IC50 390.0 nM
O=C(O)c1cnn(-c2nc3cc(Br)ccc3[nH]2)c1 CHEMBL1688403 pIC50 398.11 nM
COc1ccc2[nH]c(-n3cc(C(=O)O)cn3)nc2c1 CHEMBL1688404 pIC50 398.11 nM
Cc1cccnc1CN1CCC2(CC1)CCN(c1ccc(-c3ccncc3)cc1)C2=O CHEMBL2443124 pIC50 398.11 nM
Cc1s/c(=N/C(=O)CS(=O)(=O)c2ccccc2)n(O)c1CC(=O)O CHEMBL501554 IC50 400.0 nM
Cc1nc2c(C(=O)NCC(=O)O)nccc2n1-c1ccccc1 CHEMBL491425 IC50 400.0 nM
CCN(CC)CCNC(=O)Cc1nc(-c2ncc(C#N)c(C)c2O)sc1C CHEMBL3310408 IC50 400.0 nM
O=C(O)CNC(=O)c1ncc(-c2cccc(-c3nnn[nH]3)c2)cc1O CHEMBL3646234 IC50 400.0 nM
O=CNCCCNC(=O)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O CHEMBL3676822 IC50 400.0 nM
O=C(O)CNC(=O)c1ncc(C#CCOCCc2ccc(Cl)cc2)cc1O CHEMBL4742972 IC50 408.0 nM
O=C(O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ncccn3)cc2)C1=O CHEMBL3965432 IC50 409.0 nM
O=C(O)CCc1cs/c(=N/C(=O)CS(=O)(=O)c2ccccc2)n1O CHEMBL518141 IC50 410.0 nM
O=C(O)CNC(=O)c1ncc2c(cc(CCc3ccccc3)c(=O)n2Cc2ccccc2)c1O CHEMBL3671874 IC50 410.0 nM
CC(c1ccccc1)n1cc(-c2cnc(C(=O)NCC(=O)O)c(O)c2)nn1 CHEMBL4128469 IC50 418.3 nM
CC(C)(C)c1ccc(Cn2cc(-c3cnc(C(=O)NCC(=O)O)c(O)c3)nn2)cc1 CHEMBL4128943 IC50 418.3 nM
Cc1cc(C)cc(Cn2cc(-c3cnc(C(=O)NCC(=O)O)c(O)c3)nn2)c1 CHEMBL4129697 IC50 418.7 nM
Cc1ccc(Cn2cc(-c3cnc(C(=O)NCC(=O)O)c(O)c3)nn2)cc1 CHEMBL4129898 IC50 419.3 nM
O=C(O)c1ccnc(C(=O)O)c1 CHEMBL316034 Kd 420.0 nM
C[C@H](NC(=O)c1nc(C#N)c2c(=O)n(Cc3ccccc3)ccc2c1O)C(=O)O CHEMBL3671919 IC50 420.0 nM
COc1cccc(OCC#Cc2cnc(C(=O)NCC(=O)O)c(O)c2)c1 CHEMBL4753537 IC50 428.0 nM
O=C(O)Cn1ccnc1CN1CCC2(CC1)C(=O)N(c1cnc3ccccc3c1)c1ccccc12 CHEMBL2042408 IC50 440.0 nM
CC(C)c1ccc(-c2cnc(C(=O)NCC(=O)O)c(O)c2)cc1 CHEMBL3646223 IC50 440.0 nM
COc1ccc(CN2CCc3c(cnc(C(=O)NCC(=O)O)c3O)C2=O)c(OC)c1 CHEMBL3671929 IC50 440.0 nM
CC(=O)N(C)CCNC(=O)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O CHEMBL3671977 IC50 440.0 nM
O=C(O)CNC(=O)c1ncc(C#CCOc2ccccc2F)cc1O CHEMBL4748127 IC50 444.0 nM
CCCCc1cc(O)c(C(=O)NCC(=O)O)c2ncnn12 CHEMBL4175892 IC50 450.0 nM
O=C(O)CNC(=O)c1ncc(C#CCOc2ccc(Cl)cc2Cl)cc1O CHEMBL4763948 IC50 450.0 nM
CN(CC#Cc1cnc(C(=O)NCC(=O)O)c(O)c1)c1ccccc1 CHEMBL4757255 IC50 454.0 nM
CNC(=O)c1ncc2c(=O)n(Cc3ccc(OC)cc3OC)ccc2c1O CHEMBL3671925 IC50 500.0 nM
Cc1cccnc1CN1CCC2(CC1)CCN(c1ccc(-c3cnn(C)c3)cc1)C2=O CHEMBL2443126 pIC50 501.19 nM
C[C@H](NC(=O)c1nc(Cl)c2ccccc2c1O)C(=O)O CHEMBL485022 IC50 512.0 nM
O=C(O)CNC(=O)c1ncc(C#CCOc2ccc(C(F)(F)F)cc2)cc1O CHEMBL4781270 IC50 514.0 nM
Cc1cc2c(O)c(C(=O)NCC(=O)O)nc(-c3cccnc3)c2n(Cc2ccccc2)c1=O CHEMBL3671873 IC50 520.0 nM
O=C(O)CNC(=O)c1ncc(C#CCOc2ccc(Cl)c(Cl)c2)cc1O CHEMBL4779610 IC50 527.0 nM
Cn1cnc2c(C(=O)NCC(=O)O)nccc21 CHEMBL448208 IC50 570.0 nM
O=C(O)CNC(=O)c1ncc(-c2cn(Cc3ccc(I)cc3)nn2)cc1O CHEMBL4127429 IC50 579.7 nM
O=C(O)c1cnn(-c2ccc(COCc3ccc(Cl)cc3)cn2)c1 CHEMBL221012 IC50 580.0 nM
O=C(O)CNC(=O)c1ncc(C#CCOc2cccc(Cl)c2)cc1O CHEMBL4788975 IC50 587.0 nM
O=C(O)CNC(=O)c1ncc(C2CCN(Cc3ccc(Cl)cc3)CC2)cc1O CHEMBL5199245 IC50 588.5 nM
CS(=O)(=O)CC(=O)/N=c1/scc(CC(=O)O)n1O CHEMBL453519 IC50 600.0 nM
O=C(O)CNC(=O)c1ncc(-c2cn(Cc3ccc4ccccc4c3)nn2)cc1O CHEMBL4127491 IC50 608.2 nM
O=C(O)CNC(=O)c1nc(-c2cccnc2)c2c(cc(Cc3ccccc3)c(=O)n2Cc2ccccc2)c1O CHEMBL3671884 IC50 610.0 nM
CC(=O)NCCNC(=O)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O CHEMBL3671954 IC50 610.0 nM
Cc1cc2c(O)c(C(=O)NCC(=O)O)ncc2n(Cc2ccccc2)c1=O CHEMBL3671865 IC50 630.0 nM
Cc1cccnc1CN1CCC2(CC1)CCN(c1ccc(-c3ccccc3)nc1)C2=O CHEMBL2443128 pIC50 630.96 nM
COc1cccnc1CN1CCC2(CC1)CCN(c1ccc(-c3ccccc3)cc1)C2=O CHEMBL2443220 pIC50 630.96 nM
Cn1ccnc1CN1CCC2(CC1)C(=O)N(c1ccccc1)c1ccccc12 CHEMBL2042130 IC50 640.0 nM
Cc1ccc(-c2cnc(C(=O)NCC(=O)O)c(O)c2)cc1 CHEMBL3646215 IC50 650.0 nM
CCCNC(=O)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O CHEMBL3671898 IC50 650.0 nM
O=C(O)CNC(=O)c1c(O)ccc2ncnn12 CHEMBL4160770 IC50 650.0 nM
O=C(O)CNC(=O)c1ncc(C#CCN(c2ccccc2)c2ccccc2)cc1O CHEMBL4745628 IC50 651.0 nM
O=C(O)CCCCNC(=O)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O CHEMBL3671892 IC50 660.0 nM
CC(C)c1ccc2c(c1)C1(CCN(Cc3nccn3C)CC1)C(=O)N2c1ccccc1 CHEMBL2042131 IC50 680.0 nM
O=C(NCCNC(=O)C(F)(F)F)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O CHEMBL3671953 IC50 690.0 nM
N#Cc1nc(C(=O)NCC(=O)O)c(O)c2sc3ccccc3c12 CHEMBL2436938 IC50 700.0 nM
Cc1c(C#N)cnc(-c2nc(CC(=O)NCCc3ccccn3)cs2)c1O CHEMBL3310402 IC50 700.0 nM
N#Cc1nc(C(=O)NCCCC(=O)O)c(O)c2ccc(Oc3ccccc3)cc12 CHEMBL3894195 IC50 710.0 nM
O=C(O)CNC(=O)c1c(O)cc(C2CCCCC2)c2ncnn12 CHEMBL4162891 IC50 720.0 nM
O=C(O)CNC(=O)c1cccc2c1ncn2-c1ccccc1 CHEMBL489155 IC50 730.0 nM
CCCc1cc(O)c(C(=O)NCC(=O)O)c2ncnn12 CHEMBL4171371 IC50 730.0 nM
O=C(O)CNC(=O)c1c(O)cc(C2CCCCC2)n2ncnc12 CHEMBL4164403 IC50 730.0 nM
CC(C)(NC(=O)c1cnc(-n2cc(C(N)=O)cn2)nc1O)c1ccccc1 CHEMBL4798994 IC50 730.0 nM
O=C(O)CNC(=O)c1ncc(-c2cn(Cc3ccc(C(F)(F)F)cc3)nn2)cc1O CHEMBL4127542 IC50 759.4 nM
O=C(O)CCCNC(=O)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O CHEMBL3671891 IC50 760.0 nM
O=C1N(c2cnc3ccccc3c2)c2ccccc2C12CCN(Cc1ccccn1)CC2 CHEMBL2042267 IC50 790.0 nM
O=C1N(c2ccc(-c3ccccc3)cc2)CCC12CCN(Cc1ncccc1C(F)(F)F)CC2 CHEMBL2443219 pIC50 794.33 nM
CC(C)(C)c1ccc(S(=O)(=O)N2CC=C(c3cnc(C(=O)NCC(=O)O)c(O)c3)CC2)cc1 CHEMBL5172539 IC50 795.7 nM
Cc1sc(-c2ncc(C#N)c(C)c2O)nc1CC(=O)NCCc1ccccn1 CHEMBL3310403 IC50 800.0 nM
CNC(=O)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O CHEMBL3671894 IC50 800.0 nM
CC(=O)NCCCNC(=O)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O CHEMBL3676823 IC50 800.0 nM
O=C(O)CNC(=O)c1ncc(-c2cn(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)nn2)cc1O CHEMBL4127340 IC50 801.4 nM
O=C(O)CNC(=O)c1c(O)ccn2ncnc12 CHEMBL4174815 IC50 820.0 nM
O=C(O)CNC(=O)c1ncc(C#Cc2ccccc2)cc1O CHEMBL4746310 IC50 820.0 nM
O=C(O)CNC(=O)c1ncc(C#CCOc2ccc(-c3ccccc3)cc2)cc1O CHEMBL4796091 IC50 825.0 nM
O=C(O)CNC(=O)c1ncc(C#CC2CC2)cc1O CHEMBL4745866 IC50 835.0 nM
O=C1N(c2cnc3ccccc3c2)c2ccccc2C12CCN(Cc1ncccc1C1CC1)CC2 CHEMBL2042844 IC50 840.0 nM
CCCCCc1cc(O)c(C(=O)NCC(=O)O)c2ncnn12 CHEMBL4168030 IC50 850.0 nM
O=C(O)CNC(=O)c1ccc2cc(-c3cn(Cc4ccccc4)nn3)ccc2n1 CHEMBL4129131 IC50 853.8 nM
O=C(O)CNC(=O)c1ncc(-c2cn(Cc3ccccc3)nn2)cc1O CHEMBL4128767 IC50 853.8 nM
CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3ccc4ccccc4c3)ccc2c1O)C(=O)O CHEMBL3893917 IC50 860.0 nM
O=C(O)CNC(=O)c1ncc(C#CCOc2cccc(C(F)(F)F)c2)cc1O CHEMBL4781276 IC50 877.0 nM
O=C(O)CCC(=O)C(=O)O CHEMBL1686 Kd 900.0 nM
CN(CCNC(=O)c1ncc2c(=O)n(Cc3ccccc3)ccc2c1O)C(=O)C(F)(F)F CHEMBL3671958 IC50 900.0 nM
COc1cccc(CN2CCC3(CC2)C(=O)N(c2ccc(-c4ccccc4)cc2)C(=O)N3c2ncccn2)n1 CHEMBL4514222 IC50 905.0 nM
Cc1cc2c(O)c(C(=O)NCC(=O)O)nc(C)c2n(Cc2ccccc2)c1=O CHEMBL3671868 IC50 930.0 nM
O=C(O)CNC(=O)c1ncc(-c2cn(C(c3ccccc3)c3ccccc3)nn2)cc1O CHEMBL4129696 IC50 995.8 nM