COc1cc(N2C(=O)N(c3ccc(-c4cccc(C(=O)O)c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043169 IC50 0.2 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4C)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043325 IC50 0.2 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(-c4ccn[nH]4)cc3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2041169 IC50 0.2 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc4scnc4c3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2041175 IC50 0.2 nM
Cc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4C)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041182 IC50 0.2 nM
COc1nccnc1N1C(=O)N(c2ccc(-c3ccc(C(=O)O)cc3C)cc2)C(=O)C12CCN(Cc1ncccc1C)CC2 CHEMBL2041185 IC50 0.2 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3cnccn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 CHEMBL2041190 IC50 0.2 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3ccncn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 CHEMBL2041193 IC50 0.2 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043168 IC50 0.3 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)c(C)c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043326 IC50 0.3 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)s4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041010 IC50 0.3 nM
CNC(=O)c1ccc(-c2ccc(N3C(=O)N(c4cc(OC)ncn4)C4(CCN(Cc5ncccc5C)CC4)C3=O)cc2)cc1 CHEMBL2041178 IC50 0.3 nM
Cc1nccc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4C)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)n1 CHEMBL2041184 IC50 0.3 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3nccnc3C)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 CHEMBL2041186 IC50 0.3 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3ncccn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 CHEMBL2041188 IC50 0.3 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(C(=O)O)cc3)cc1)C(=O)N2c1ccncn1 CHEMBL2041192 IC50 0.3 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4F)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043324 IC50 0.4 nM
Cc1nc(C)c(-c2ccc(N3C(=O)N(c4cc(O)ncn4)C4(CCN(Cc5ncccc5C)CC4)C3=O)cc2)s1 CHEMBL2040897 IC50 0.4 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3cc(C(F)(F)F)ncn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 CHEMBL2041183 IC50 0.4 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(C(=O)O)cc3)cc1)C(=O)N2c1cnccn1 CHEMBL2041189 IC50 0.4 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(N4CCOCC4)cc3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2041170 IC50 0.5 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3cc(O)ncn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cn1 CHEMBL2040854 IC50 0.5 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(N)=O)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041177 IC50 0.7 nM
COc1cc(N2C(=O)N(c3ccc(-c4csc(C(=O)O)c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041164 IC50 0.8 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(-c5cc(=O)[nH][nH]5)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041171 IC50 0.8 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4Cl)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043171 IC50 0.9 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3cnccn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cn1 CHEMBL2041191 IC50 1.0 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3ccncn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cn1 CHEMBL2041194 IC50 1.0 nM
COc1ccc(C(NC(=O)c2cnc(-c3cccnn3)nc2O)c2ccc(OC)cc2)cc1 CHEMBL4783524 IC50 1.0 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccccc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3C(=O)O)ncn1 CHEMBL2043010 IC50 1.1 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(C(=O)O)cc3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2043011 IC50 1.1 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C#N)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041176 IC50 1.1 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4)nc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041180 IC50 1.1 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)c(Cl)c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043172 IC50 1.2 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(C(=O)O)cc3)cc1)C(=O)N2c1ncccn1 CHEMBL2041187 IC50 1.2 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2043004 IC50 1.3 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1cccc(O)n1 CHEMBL2043003 IC50 1.4 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1cc(O)ccn1 CHEMBL2043006 IC50 1.4 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1ccnc(O)n1 CHEMBL2043007 IC50 1.4 nM
N#Cc1ccc(C2Cn3c(=O)c(C(=O)NCC(=O)O)c(O)c4cc(OC(F)(F)F)cc(c43)O2)cc1 CHEMBL4451025 IC50 1.4 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4C)nc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041181 IC50 1.6 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1ncccn1 CHEMBL2043005 IC50 1.7 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1nccc(O)n1 CHEMBL2043002 IC50 1.8 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc5nc[nH]c5c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041174 IC50 1.8 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(C3CCCCC3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2043327 IC50 1.9 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3cnc(O)nc3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2041167 IC50 2.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1ccc(O)nn1 CHEMBL2043008 IC50 2.1 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc5cn[nH]c5c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041172 IC50 2.1 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(Cl)cc3)c1=O)COC2 CHEMBL4462855 IC50 2.1 nM
O=C(O)CNC(=O)c1c(O)c2cccc3c2n(c1=O)C(c1cncs1)CO3 CHEMBL4443606 IC50 2.1 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(F)cc3F)c1=O)COC2 CHEMBL4529447 IC50 2.2 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc5[nH]ncc5c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041173 IC50 2.3 nM
O=C(O)CNC(=O)c1c(O)c2cccc3c2n(c1=O)CC(c1ccc(C(F)(F)F)nc1)N3 CHEMBL4452218 IC50 2.3 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3cnc(C(F)(F)F)s3)c1=O)COC2 CHEMBL4590677 IC50 2.4 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(OC(F)(F)F)cc3)c1=O)COC2 CHEMBL4561977 IC50 2.4 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3cc(F)c(F)cc3F)c1=O)COC2 CHEMBL4462741 IC50 3.1 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccn(-c4ccccc4)n3)c1=O)COC2 CHEMBL4476576 IC50 3.2 nM
O=C(O)CNC(=O)c1c(O)c2ccc(Cl)cc2n(Cc2ccc(C(F)(F)F)cc2)c1=O CHEMBL4564341 IC50 3.2 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3nc4ccccc4s3)c1=O)CCOC2 CHEMBL4162309 IC50 3.3 nM
O=C(O)CNC(=O)c1c(O)n(C2CCCCC2)c(=O)n(C2CCCCC2)c1=O CHEMBL4163812 IC50 3.5 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)nc3)c1=O)COC2 CHEMBL4458708 IC50 3.6 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)cc3)c1=O)COC2 CHEMBL4577928 IC50 3.6 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)N(C)C)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041179 IC50 3.7 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3nc(C(F)(F)F)cs3)c1=O)COC2 CHEMBL4452138 IC50 3.7 nM
O=C(O)CNC(=O)c1c(O)c2cccc3c2n(c1=O)CC(c1ccc(C(F)(F)F)cc1)S3 CHEMBL4454844 IC50 3.8 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccno3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2040896 IC50 4.5 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3cnc(C(F)(F)F)cn3)c1=O)COC2 CHEMBL4567141 IC50 4.9 nM
O=C(O)CNC(=O)c1c(O)c2cccc3c2n(c1=O)C(c1ccc(C(F)(F)F)nc1)CO3 CHEMBL4552680 IC50 4.9 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3nc4ccccc4o3)c1=O)COC2 CHEMBL4474474 IC50 5.0 nM
COc1cc(N2C(=O)N(c3ccc(-c4coc(C(=O)O)c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041165 IC50 5.5 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3cncnc3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2041166 IC50 5.6 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(Cl)cc3)c1=O)CCOC2 CHEMBL4471891 IC50 5.9 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(-c5ccn[nH]5)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041168 IC50 6.0 nM
CC(C)(O)c1ccc(Cn2c3c(c(O)c(C(=O)NCC(=O)O)c2=O)COC3)cc1 CHEMBL4483401 IC50 6.2 nM
N#Cc1ccc(Cn2c3c(c(O)c(C(=O)NCC(=O)O)c2=O)COCC3)c(F)c1 CHEMBL4573825 IC50 6.3 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)nc3)c1=O)CCOC2 CHEMBL4461978 IC50 6.8 nM
CC(=O)Nc1cc(-c2ccc(C#N)cc2)n2ncnc2c1 CHEMBL4067995 IC50 8.0 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccccc4C(=O)O)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043170 IC50 8.2 nM
N#Cc1ccc(-c2cccc3ncnn23)cc1F CHEMBL4090769 IC50 10.0 nM
COCc1nc(-c2ccc(N3C(=O)N(c4cc(O)ncn4)C4(CCN(Cc5ncccc5C)CC4)C3=O)cc2)no1 CHEMBL2040894 IC50 11.0 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3cnc(C(F)(F)F)nc3)c1=O)COC2 CHEMBL4582737 IC50 11.0 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)cc3)c1=O)COCC2 CHEMBL4469994 IC50 11.0 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ncc(C(F)(F)F)cn3)c1=O)COC2 CHEMBL4516521 IC50 12.0 nM
N#Cc1ccc(-c2cc(N)cc3ncnn23)cc1 CHEMBL4072842 IC50 13.0 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)cc3)c1=O)CCOC2 CHEMBL4582939 IC50 14.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(N3CCC3=O)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2043328 IC50 17.0 nM
CCNc1cc(-c2ccc(C#N)cc2)n2ncnc2c1 CHEMBL4094292 IC50 25.0 nM
COc1ccc(C2COc3cccc4c(O)c(C(=O)NCC(=O)O)c(=O)n2c34)cc1 CHEMBL4473810 IC50 27.0 nM
N#Cc1ccc(-c2cccc3ncnn23)cc1 CHEMBL4083851 IC50 34.0 nM
N#Cc1c(F)cc(-c2cccc3ncnn23)cc1F CHEMBL4067559 IC50 34.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-n3cccn3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2040895 IC50 38.0 nM
Cc1cc(-c2ccc(C#N)cc2)n2ncnc2c1 CHEMBL4095005 IC50 39.0 nM
CC(C)(C)OC(=O)c1ccc(-n2[nH]cc(-n3ccnn3)c2=O)nc1 CHEMBL3646117 IC50 50.0 nM
N#Cc1ccc(-c2cccc3ncnn23)c(F)c1 CHEMBL4075128 IC50 50.0 nM
Cc1c(-c2cccc3ncnn23)ccc(C#N)c1F CHEMBL4102714 IC50 52.0 nM
N#Cc1ccc(-c2cccc3ncnn23)c(N)c1 CHEMBL4104731 IC50 57.0 nM
N#Cc1ccc(-c2cccc3ncnn23)c(F)c1F CHEMBL4094977 IC50 67.0 nM
CC(=O)Nc1cc(-c2ccc(C#N)cc2C)n2ncnc2c1 CHEMBL4081861 IC50 70.0 nM
Cc1cc(C#N)ccc1-c1cccc2ncnn12 CHEMBL4076493 IC50 74.0 nM
N#Cc1ncc(-c2cccc3ncnn23)cn1 CHEMBL4093533 IC50 84.0 nM
Cc1cc(C#N)ccc1-c1cc(N)cc2ncnn12 CHEMBL4073446 IC50 90.0 nM
N#Cc1nc(C(=O)NC[C@H](O)C(=O)O)c(O)c2ccc(Oc3ccccc3)cc12 CHEMBL3965639 IC50 110.0 nM
N#Cc1nc(C(=O)NCC2(C(=O)O)CCC2)c(O)c2ccc(Sc3ccccc3)cc12 CHEMBL4114889 IC50 110.0 nM
CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3ccc4ccccc4c3)ccc2c1O)C(=O)O CHEMBL3893917 IC50 130.0 nM
N#Cc1nc(C(=O)NCCCC(=O)O)c(O)c2ccc(Oc3ccccc3)cc12 CHEMBL3894195 IC50 140.0 nM
Cc1cc(C#N)c(F)cc1-c1cccc2ncnn12 CHEMBL4086321 IC50 140.0 nM
COc1cc(C#N)ccc1-c1cccc2ncnn12 CHEMBL4068120 IC50 140.0 nM
N#Cc1ccc(-c2cccc3ncnn23)c(Cl)c1 CHEMBL4076409 IC50 140.0 nM
N#Cc1nc(C(=O)NCC(O)C(=O)O)c(O)c2ccc(Oc3ccccc3)cc12 CHEMBL3978897 IC50 160.0 nM
C[C@@H](CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(=O)O CHEMBL3909096 IC50 160.0 nM
N#Cc1cc(F)c(-c2cccc3ncnn23)c(F)c1 CHEMBL4078461 IC50 160.0 nM
N#Cc1nc(C(=O)NCC2(C(=O)O)CC2)c(O)c2ccc(Oc3ccccc3)cc12 CHEMBL3926169 IC50 170.0 nM
N#Cc1ccc(-c2cccc3ncnn23)cn1 CHEMBL4059941 IC50 170.0 nM
CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3cccc(Cl)c3)ccc2c1O)C(=O)O CHEMBL3894876 IC50 180.0 nM
CC(C)(C)COc1ccc(-n2[nH]cc(-n3ccnn3)c2=O)nc1 CHEMBL3646120 IC50 190.0 nM
Cc1cc(C#N)cc(C)c1-c1cccc2ncnn12 CHEMBL4094084 IC50 200.0 nM
CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3cccc4ccccc34)ccc2c1O)C(=O)O CHEMBL3930984 IC50 220.0 nM
Cc1cc(C#N)cc(F)c1-c1cccc2ncnn12 CHEMBL4064841 IC50 220.0 nM
N#Cc1nc(C(=O)NC[C@@H](O)CC(=O)O)c(O)c2ccc(Oc3ccccc3)cc12 CHEMBL3957570 IC50 230.0 nM
N#Cc1nc(C(=O)NCCC(=O)O)c(O)c2ccc(Oc3ccccc3)cc12 CHEMBL3908079 IC50 240.0 nM
COc1ccc(Oc2ccc3c(O)c(C(=O)NC(C)(C)CC(=O)O)nc(C#N)c3c2)cc1 CHEMBL3905420 IC50 240.0 nM
CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3Cl)ccc2c1O)C(=O)O CHEMBL3897439 IC50 240.0 nM
COC(=O)NC(CCNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(=O)O CHEMBL3983370 IC50 240.0 nM
N#Cc1nc(C(=O)NCC[C@H](O)C(=O)O)c(O)c2ccc(Oc3ccccc3)cc12 CHEMBL3942261 IC50 240.0 nM
N#Cc1ccc(-c2cccc3nc(N)nn23)cc1 CHEMBL4081340 IC50 240.0 nM
N#Cc1nc(C(=O)NCCC(=O)C(=O)O)c(O)c2ccc(Oc3ccccc3)cc12 CHEMBL3939854 IC50 260.0 nM
N#Cc1nc(C(=O)NCCCCC(=O)O)c(O)c2ccc(Oc3ccc(F)cc3Cl)cc12 CHEMBL3919532 IC50 270.0 nM
N#Cc1ccc(-c2cccc3ncnn23)nc1 CHEMBL4065934 IC50 270.0 nM
Cc1ccc(Oc2ccc3c(O)c(C(=O)NCC(C)(C)C(=O)O)nc(C#N)c3c2)cc1 CHEMBL3924386 IC50 280.0 nM
CC(=O)N[C@H](CCNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(=O)O CHEMBL4111822 IC50 280.0 nM
C[C@H](CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(=O)O CHEMBL4111670 IC50 280.0 nM
N#CC1CCN(c2cccc3ncnn23)CC1 CHEMBL4082314 IC50 280.0 nM
CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3ccc(F)cc3Cl)ccc2c1O)C(=O)O CHEMBL3950407 IC50 290.0 nM
CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3ccc(Cl)cc3)ccc2c1O)C(=O)O CHEMBL3902935 IC50 300.0 nM
N#Cc1nc(C(=O)NCC2(C(=O)O)CCC2)c(O)c2ccc(Oc3ccccc3)cc12 CHEMBL4107860 IC50 310.0 nM
CO[C@@H](CCNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(=O)O CHEMBL3976225 IC50 310.0 nM
Cc1ccnc(-n2[nH]cc(-n3ccnn3)c2=O)c1 CHEMBL3646107 IC50 340.0 nM
CC(C)(CCNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(=O)O CHEMBL3971858 IC50 340.0 nM
CCSc1cc(-n2[nH]cc(-n3ccnn3)c2=O)ncn1 CHEMBL3646123 IC50 350.0 nM
COc1ccc(Oc2ccc3c(O)c(C(=O)NCC(C)(C)C(=O)O)nc(C#N)c3c2)cc1 CHEMBL3914279 IC50 350.0 nM
O=C(O)CCNC(=O)c1ncc2cc(S(=O)(=O)C3CCCCC3)ccc2c1O CHEMBL3958567 IC50 350.0 nM
CC1CCN(c2cc(-n3[nH]cc(-n4ccnn4)c3=O)ncn2)CC1 CHEMBL3646125 IC50 360.0 nM
CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3cccc(F)c3)ccc2c1O)C(=O)O CHEMBL3911949 IC50 360.0 nM
CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(=O)O CHEMBL3961990 IC50 410.0 nM
CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3ccc(F)cc3)ccc2c1O)C(=O)O CHEMBL3945129 IC50 410.0 nM
N#Cc1nc(C(=O)NCCCCC(=O)O)c(O)c2ccc(Oc3ccccc3)cc12 CHEMBL3970759 IC50 420.0 nM
N#Cc1nc(C(=O)NCC(C(=O)O)C2CC2)c(O)c2ccc(Oc3ccccc3)cc12 CHEMBL3941206 IC50 420.0 nM
Cc1ccc2ncnn2c1-c1ccc(C#N)cc1 CHEMBL4063144 IC50 460.0 nM
N#Cc1ccc(-c2c(F)ccc3ncnn23)cc1 CHEMBL4089934 IC50 460.0 nM
[O-]c1c(-n2ccnn2)cnn1-c1cc(N2CCOCC2)ncn1 CHEMBL3931782 IC50 480.0 nM
CCc1ccccc1Oc1ccc2c(O)c(C(=O)NCC(C)(C)C(=O)O)nc(C#N)c2c1 CHEMBL3916427 IC50 480.0 nM
O=c1c(-n2ccnn2)c[nH]n1-c1cc(N2CCOCC2)ncn1 CHEMBL3646118 IC50 480.0 nM
O=c1c(-n2ccnc2)c[nH]n1-c1cc(N2CCCCC2)ncn1 CHEMBL3646108 IC50 500.0 nM
CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3cc(F)ccc3Cl)ccc2c1O)C(=O)O CHEMBL3914953 IC50 530.0 nM
CC(C)(CC(=O)O)NC(=O)c1nc(C#N)c2cc(Oc3ccc(F)cc3)ccc2c1O CHEMBL3904114 IC50 530.0 nM
CCC(CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(=O)O CHEMBL3964092 IC50 540.0 nM
CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3F)ccc2c1O)C(=O)O CHEMBL3985165 IC50 550.0 nM
Clc1ccc(-c2cccc3ncnn23)cc1 CHEMBL4070540 IC50 550.0 nM
O=c1c(-n2ccnn2)c[nH]n1-c1cc(C2CC2)ncn1 CHEMBL3646110 IC50 560.0 nM
Cc1nc2cccc(-c3ccc(C#N)cc3)n2n1 CHEMBL4073471 IC50 570.0 nM
N#Cc1nc(C(=O)NCCC(=O)O)c(O)c2ccc(-c3ccccc3)cc12 CHEMBL3953309 IC50 610.0 nM
Clc1ccc(-c2cccc3ncnn23)c(Cl)c1 CHEMBL4103861 IC50 670.0 nM
COC1CCCN(c2cc(-n3[nH]cc(-n4ccnc4)c3=O)ncn2)C1 CHEMBL3646126 IC50 690.0 nM
N#Cc1nc(C(=O)NCC2(C(=O)O)CCC2)c(O)c2ccc(Oc3c(F)cccc3F)cc12 CHEMBL4108440 IC50 700.0 nM
N#Cc1nc(C(=O)NCC(F)(F)C(=O)O)c(O)c2ccc(Oc3ccccc3)cc12 CHEMBL3901774 IC50 730.0 nM
O=c1c(-n2ccnn2)c[nH]n1-c1cc(N2CCSCC2)ncn1 CHEMBL3646124 IC50 740.0 nM
C[C@](O)(CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(=O)O CHEMBL3932515 IC50 740.0 nM
CC(C)(CCCNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(=O)O CHEMBL3943957 IC50 740.0 nM
O=c1c(-n2cnc(C(F)(F)F)c2)c[nH]n1-c1ccc(CO)cn1 CHEMBL3646109 IC50 750.0 nM
N#Cc1nc(C(=O)NCC(C(=O)O)C2CC2)c(O)c2ccc(Oc3ccccc3F)cc12 CHEMBL3902198 IC50 750.0 nM
N#Cc1ccc(-c2c(N)ccc3ncnn23)cc1 CHEMBL4085560 IC50 770.0 nM
CC(C)c1cn(-c2c[nH]n(-c3ccc(CO)cn3)c2=O)nn1 CHEMBL3646112 IC50 780.0 nM
COc1ccc(Oc2ccc3c(O)c(C(=O)NC[C@H](O)C(=O)O)ncc3c2)cc1 CHEMBL3985211 IC50 790.0 nM
Cc1cc(-c2cccc3ncnn23)ccc1C#N CHEMBL4069766 IC50 830.0 nM
CC(C)(CNC(=O)c1nc(C#N)c2cc(Sc3ccccc3)ccc2c1O)C(=O)O CHEMBL3927164 IC50 840.0 nM
O=C(O)CNC(=O)C(=O)O CHEMBL90852 IC50 842.0 nM
O=C(O)CCNC(=O)c1ncc2cc(NC(=O)NCc3ccccc3)ccc2c1O CHEMBL3951211 IC50 850.0 nM
CC(C)(CC(=O)O)NC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O CHEMBL3973992 IC50 910.0 nM
N#Cc1nc(C(=O)NCC2(C(=O)O)CCC2)c(O)c2ccc(OC3CCCCC3)cc12 CHEMBL4112556 IC50 910.0 nM
O=C(O)CCNC(=O)c1ncc2cc(Oc3ccccc3)ccc2c1O CHEMBL3904422 IC50 920.0 nM
CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3c(F)cccc3F)ccc2c1O)C(=O)O CHEMBL3933422 IC50 930.0 nM
C[C@H](CC(=O)O)NC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O CHEMBL4110438 IC50 930.0 nM
CC(C)(CCC(=O)O)NC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O CHEMBL3961958 IC50 940.0 nM
N#Cc1nc(C(=O)NCC(C(=O)O)C2CC2)c(O)c2ccc(Oc3ccc(F)cc3)cc12 CHEMBL3911999 IC50 950.0 nM