N#Cc1cnc(-c2nc(CC(=O)N3CCC3)cs2)c(O)c1 CHEMBL3115315 IC50 0.0 nM
O=C(O)CCn1nnc2ccccc21 CHEMBL3133890 Kd 0.00347 nM
c1ccc2[nH]c(CCn3cncn3)nc2c1 CHEMBL3133891 Kd 0.00567 nM
c1ccc2[nH]c(CCn3nnc4ccccc43)nc2c1 CHEMBL3133892 Kd 0.00734 nM
O=C(O)CCn1cnc2ccccc21 CHEMBL3133889 Kd 0.0152 nM
O=C(O)CCn1ccnc1 CHEMBL20724 Kd 0.0544 nM
O=C(O)CCn1cncn1 CHEMBL3133888 Kd 0.0784 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3cnccn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 CHEMBL2041190 IC50 0.8 nM
CC(C)(C)c1ccc(Cn2nc(-c3ccc(Cl)cc3)c(O)c(C(=O)NCC(=O)O)c2=O)cc1 CHEMBL3115284 IC50 0.8 nM
CC(C)(C)c1ccc(Cn2c(-c3c(Cl)cccc3Cl)nc(O)c(C(=O)NCC(=O)O)c2=O)cc1 CHEMBL3115283 IC50 0.8 nM
N#Cc1ccccc1Cn1c(=O)c(C(=O)NCC(=O)O)c(O)n(Cc2ccccc2)c1=O CHEMBL3115282 IC50 0.8 nM
COc1ccc(-n2c(=O)[nH]c3cc(C(=O)NCc4ccc5c(c4)OCO5)sc3c2=O)nc1OC CHEMBL3115295 IC50 1.0 nM
COc1ccc(-n2c(=O)[nH]c3cc(C(=O)NCc4ccc(Cl)cc4)ncc3c2=O)nc1OC CHEMBL3115296 IC50 1.0 nM
COc1ccc(-n2c(=S)[nH]c3sc(C(=O)NCc4ccc(Cl)cc4)c(C)c3c2=O)nc1OC CHEMBL3115294 IC50 1.0 nM
COc1ccc(-n2c(=S)[nH]c3cc(C(=O)NCc4ccc(Cl)cc4)sc3c2=O)nc1OC CHEMBL3115293 IC50 1.0 nM
O=C(O)CNC(=O)c1c(O)c(Br)cc2c1ncn2Cc1ccccc1 CHEMBL3115292 IC50 1.0 nM
O=C(O)CNC(=O)c1c2ncn(Cc3ccccc3)c2cc2c1ncn2Cc1ccccc1 CHEMBL3115291 IC50 1.0 nM
O=C(O)CNC(=O)c1c(O)c(-c2cccnc2)cc2nccnc12 CHEMBL3115290 IC50 1.0 nM
O=C(O)CNC(=O)c1c(O)ccc2cc(-c3ccccc3)cnc12 CHEMBL3115289 IC50 1.0 nM
O=C(O)CNC(=O)c1c(O)c(C(=O)NCc2ccccc2)c(O)n(Cc2ccccc2)c1=O CHEMBL3115288 EC50 1.0 nM
O=C(O)CNC(=O)c1c(O)c(C(=O)NCc2ccccc2)cn(Cc2ccccc2)c1=O CHEMBL3115287 EC50 1.0 nM
COc1ccc(-n2c(=O)[nH]c3cc(C(=O)NCc4ccc(Cl)cc4)sc3c2=O)nc1OC CHEMBL4173371 IC50 1.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc4scnc4c3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2041175 IC50 1.6 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3ccncn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 CHEMBL2041193 IC50 1.6 nM
COc1cc(N2C(=O)N(c3ccc(-c4cccc(C(=O)O)c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043169 IC50 1.7 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4C)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043325 IC50 1.9 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)s4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041010 IC50 2.0 nM
COc1nccnc1N1C(=O)N(c2ccc(-c3ccc(C(=O)O)cc3C)cc2)C(=O)C12CCN(Cc1ncccc1C)CC2 CHEMBL2041185 IC50 2.0 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043168 IC50 2.1 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(C(=O)O)cc3)cc1)C(=O)N2c1ccncn1 CHEMBL2041192 IC50 2.1 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3ncccn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 CHEMBL2041188 IC50 2.9 nM
Cc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4C)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041182 IC50 3.2 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccccc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3C(=O)O)ncn1 CHEMBL2043010 IC50 3.5 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(-c4ccn[nH]4)cc3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2041169 IC50 3.5 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4F)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043324 IC50 3.6 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3cc(C(F)(F)F)ncn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 CHEMBL2041183 IC50 4.1 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(C(=O)O)cc3)cc1)C(=O)N2c1cnccn1 CHEMBL2041189 IC50 4.8 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3nccnc3C)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 CHEMBL2041186 IC50 4.9 nM
N#Cc1ccc(C2Cn3c(=O)c(C(=O)NCC(=O)O)c(O)c4cc(OC(F)(F)F)cc(c43)O2)cc1 CHEMBL4451025 IC50 5.1 nM
O=C(O)CNC(=O)c1c(O)n(C2CCCCC2)c(=O)n(C2CCCCC2)c1=O CHEMBL4163812 IC50 5.5 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)c(C)c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043326 IC50 5.8 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(OC(F)(F)F)cc3)c1=O)COC2 CHEMBL4561977 IC50 5.8 nM
Cc1nc(C)c(-c2ccc(N3C(=O)N(c4cc(O)ncn4)C4(CCN(Cc5ncccc5C)CC4)C3=O)cc2)s1 CHEMBL2040897 IC50 5.9 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccn(-c4ccccc4)n3)c1=O)COC2 CHEMBL4476576 IC50 6.0 nM
COc1cc(N2C(=O)N(c3ccc(-c4csc(C(=O)O)c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041164 IC50 6.4 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(Cl)cc3)c1=O)COC2 CHEMBL4462855 IC50 6.4 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3cnc(C(F)(F)F)s3)c1=O)COC2 CHEMBL4590677 IC50 6.4 nM
O=C(O)CNC(=O)c1c(O)c2cccc3c2n(c1=O)CC(c1ccc(C(F)(F)F)nc1)N3 CHEMBL4452218 IC50 6.6 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3cc(F)c(F)cc3F)c1=O)COC2 CHEMBL4462741 IC50 6.6 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3nc4ccccc4o3)c1=O)COC2 CHEMBL4474474 IC50 6.6 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(C(=O)O)cc3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2043011 IC50 7.2 nM
Cc1nccc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4C)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)n1 CHEMBL2041184 IC50 7.7 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3nc(C(F)(F)F)cs3)c1=O)COC2 CHEMBL4452138 IC50 7.8 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)cc3)c1=O)COC2 CHEMBL4577928 IC50 8.2 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)c(Cl)c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043172 IC50 8.4 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(F)cc3F)c1=O)COC2 CHEMBL4529447 IC50 8.8 nM
O=C(O)CNC(=O)c1c(O)c2cccc3c2n(c1=O)C(c1ccc(C(F)(F)F)nc1)CO3 CHEMBL4552680 IC50 8.9 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(N4CCOCC4)cc3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2041170 IC50 9.8 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(C(=O)O)cc3)cc1)C(=O)N2c1ncccn1 CHEMBL2041187 IC50 10.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2043004 IC50 11.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1ncccn1 CHEMBL2043005 IC50 11.0 nM
O=C(O)CNC(=O)c1c(O)c2cccc3c2n(c1=O)CC(c1ccc(C(F)(F)F)cc1)S3 CHEMBL4454844 IC50 13.0 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)nc3)c1=O)COC2 CHEMBL4458708 IC50 13.0 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3cnc(C(F)(F)F)cn3)c1=O)COC2 CHEMBL4567141 IC50 13.0 nM
CNC(=O)c1ccc(-c2ccc(N3C(=O)N(c4cc(OC)ncn4)C4(CCN(Cc5ncccc5C)CC4)C3=O)cc2)cc1 CHEMBL2041178 IC50 14.0 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3nc4ccccc4s3)c1=O)CCOC2 CHEMBL4162309 IC50 14.0 nM
COc1ccc(C(NC(=O)c2cnc(-c3cccnn3)nc2O)c2ccc(OC)cc2)cc1 CHEMBL4783524 IC50 14.0 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(N)=O)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041177 IC50 15.0 nM
O=C(O)CNC(=O)c1c(O)c2ccc(Cl)cc2n(Cc2ccc(C(F)(F)F)cc2)c1=O CHEMBL4564341 IC50 16.0 nM
CC(C)(O)c1ccc(Cn2c3c(c(O)c(C(=O)NCC(=O)O)c2=O)COC3)cc1 CHEMBL4483401 IC50 16.0 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C#N)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041176 IC50 17.0 nM
O=C(O)CNC(=O)c1ncc(-c2ccc3ccccc3c2)cc1O CHEMBL2338326 IC50 17.0 nM
N#Cc1ccc(Cn2c3c(c(O)c(C(=O)NCC(=O)O)c2=O)COCC3)c(F)c1 CHEMBL4573825 IC50 18.0 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3cnc(C(F)(F)F)nc3)c1=O)COC2 CHEMBL4582737 IC50 18.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1nccc(O)n1 CHEMBL2043002 IC50 20.0 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4)nc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041180 IC50 20.0 nM
O=C(O)CNC(=O)c1c(O)c2ccc(F)cc2n(Cc2ccccc2Cl)c1=O CHEMBL3115281 IC50 20.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3cnc(O)nc3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2041167 IC50 21.0 nM
COc1ccc(C2COc3cccc4c(O)c(C(=O)NCC(=O)O)c(=O)n2c34)cc1 CHEMBL4473810 IC50 21.0 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3ccncn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cn1 CHEMBL2041194 IC50 22.0 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ncc(C(F)(F)F)cn3)c1=O)COC2 CHEMBL4516521 IC50 22.0 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc5nc[nH]c5c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041174 IC50 24.0 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3cc(O)ncn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cn1 CHEMBL2040854 IC50 26.0 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4Cl)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043171 IC50 27.0 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(Cl)cc3)c1=O)CCOC2 CHEMBL4471891 IC50 33.0 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4C)nc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041181 IC50 36.0 nM
COc1cc(N2C(=O)N(c3ccc(-c4coc(C(=O)O)c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041165 IC50 38.0 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(-c5cc(=O)[nH][nH]5)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041171 IC50 38.0 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)cc3)c1=O)COCC2 CHEMBL4469994 IC50 40.0 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)nc3)c1=O)CCOC2 CHEMBL4461978 IC50 41.0 nM
Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3cnccn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cn1 CHEMBL2041191 IC50 43.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1ccnc(O)n1 CHEMBL2043007 IC50 44.0 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc5[nH]ncc5c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041173 IC50 47.0 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc5cn[nH]c5c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041172 IC50 48.0 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)N(C)C)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041179 IC50 49.0 nM
O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)cc3)c1=O)CCOC2 CHEMBL4582939 IC50 51.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1ccc(O)nn1 CHEMBL2043008 IC50 59.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(N3CCC3=O)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2043328 IC50 61.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3cncnc3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2041166 IC50 61.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccno3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2040896 IC50 76.0 nM
O=C(O)CNC(=O)c1ncc(-c2ccc(Cl)cc2)cc1O CHEMBL3646220 IC50 83.0 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccccc4C(=O)O)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2043170 IC50 95.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1cccc(O)n1 CHEMBL2043003 IC50 97.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1cc(O)ccn1 CHEMBL2043006 IC50 97.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(C3CCCCC3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2043327 IC50 120.0 nM
COc1cc(N2C(=O)N(c3ccc(-c4ccc(-c5ccn[nH]5)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 CHEMBL2041168 IC50 130.0 nM
Cc1ccc(-c2cnc(C(=O)NCC(=O)O)c(O)c2)cc1 CHEMBL3646215 IC50 180.0 nM
CCc1ccc2cc(CCn3ncc4nc(-n5cc(C(=O)O)cn5)nc(O)c43)ccc2c1 CHEMBL4170656 IC50 180.0 nM
Cn1ccnc1CN1CCC2(CC1)NC(=O)N(c1ccc(-c3ccccc3)cc1)C2=O CHEMBL4482885 IC50 219.0 nM
Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-n3cccn3)cc1)C(=O)N2c1cc(O)ncn1 CHEMBL2040895 IC50 320.0 nM
COCc1nc(-c2ccc(N3C(=O)N(c4cc(O)ncn4)C4(CCN(Cc5ncccc5C)CC4)C3=O)cc2)no1 CHEMBL2040894 IC50 340.0 nM
O=C(O)CNC(=O)c1ncc(-c2ccccc2Cl)cc1O CHEMBL3646222 IC50 390.0 nM
O=C(O)CNC(=O)c1ncc(-c2cccc(Cl)c2)cc1O CHEMBL3646221 IC50 390.0 nM
[O-]c1c(-n2ccnn2)cnn1-c1cc(N2CCOCC2)ncn1 CHEMBL3931782 IC50 450.0 nM
O=c1c(-n2ccnn2)c[nH]n1-c1cc(N2CCOCC2)ncn1 CHEMBL3646118 IC50 450.0 nM
[C-]#[N+]c1ccc(-c2cnc(C(=O)NCC(=O)O)c(O)c2)cc1 CHEMBL3646219 IC50 560.0 nM