COc1cc2c(cc1OC)-c1[nH]nc(NCc3c(Cl)cccc3Cl)c1C2=O CHEMBL573760 pIC50 6.31 nM
COc1cc2c(cc1OC)-c1[nH]nc(NCc3c(C)cccc3C)c1C2 CHEMBL578426 pIC50 7.943 nM
COc1cc2c(cc1OC)-c1[nH]nc(NCc3c(C)cccc3Cl)c1C2 CHEMBL576168 pIC50 19.95 nM
CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4281823 IC50 26.0 nM
COc1cc2c(cc1OCC(O)CO)Cc1c(NCc3c(Cl)cccc3Cl)n[nH]c1-2 CHEMBL574005 pIC50 31.62 nM
Cn1cc(-c2ccc3c(c2F)CCN3C(=O)Cc2cccc(C(F)(F)F)n2)c2c(N)ncnc21 CHEMBL2441342 IC50 37.0 nM
COc1ccc2c(c1)-c1[nH]nc(NCc3c(C)cccc3Cl)c1C2 CHEMBL578836 pIC50 50.12 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL428690 Kd apparent 58.0 nM
Cc1cc(C)n(CC(=O)N2CCc3c2ccc(-c2cn(C)c4ncnc(N)c24)c3F)n1 CHEMBL2441346 IC50 61.0 nM
COc1cc2c(cc1OC)-c1[nH]nc(NCc3ccccc3C)c1C2 CHEMBL574443 pIC50 63.1 nM
COc1cc2oc3c(NCc4c(Cl)cccc4Cl)n[nH]c3c2cc1OC CHEMBL565272 pIC50 63.1 nM
COc1cc2c(cc1OC)S(=O)(=O)c1c(NCc3c(Cl)cccc3Cl)n[nH]c1-2 CHEMBL583635 pIC50 79.43 nM
COc1cc(OC)c2c(c1)-c1[nH]nc(NCc3c(C)cccc3Cl)c1C2 CHEMBL574209 pIC50 125.89 nM
COc1cc(CCc2cc(NC(=O)c3ccc(N4CC(C)NC(C)C4)cc3)n[nH]2)cc(OC)c1 CHEMBL3184679 Kd apparent 170.0 nM
COc1cc2c(cc1OC)-c1[nH]nc(NCc3ccccc3Cl)c1C2 CHEMBL573763 pIC50 199.53 nM
Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(Cl)c2)c2c(N)ncnc21 CHEMBL2171122 IC50 214.0 nM
Cc1cccc(Cl)c1CNc1n[nH]c2c1Cc1cc3c(cc1-2)OCO3 CHEMBL573770 pIC50 251.19 nM
Cc1cccc(Cl)c1CNc1n[nH]c2c1Cc1ccc(N(C)C)cc1-2 CHEMBL574009 pIC50 251.19 nM
CCc1ccc2c(c1)-c1[nH]nc(NCc3c(C)cccc3Cl)c1C2 CHEMBL576948 pIC50 316.23 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1 CHEMBL2105759 Kd apparent 335.0 nM
Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(C(F)(F)F)c2)c2c(N)ncnc21 CHEMBL2171124 IC50 420.0 nM
Cc1cccc(CC(=O)N2CCc3c2ccc(-c2cn(C)c4ncnc(N)c24)c3F)n1 CHEMBL2441340 IC50 460.0 nM
COc1ccc2c(c1)Cc1c(NCc3c(C)cccc3Cl)n[nH]c1-2 CHEMBL575913 pIC50 501.19 nM
COc1cc2sc3c(NCc4c(C)cccc4Cl)n[nH]c3c2cc1OC CHEMBL582642 pIC50 501.19 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 630.0 nM
COc1cc2c(cc1OC)-c1[nH]nc(NCc3ccccc3)c1C2 CHEMBL574208 pIC50 630.96 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc4ncccc4c3)c(F)c2)ccn1 CHEMBL1738757 Kd apparent 666.0 nM
COc1cccc2c1Cc1c(NCc3c(C)cccc3Cl)n[nH]c1-2 CHEMBL575914 pIC50 794.33 nM
Cc1cccc(Cl)c1CNc1n[nH]c2c1Cc1ccc(Br)cc1-2 CHEMBL573280 pIC50 794.33 nM
CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1 CHEMBL2028663 Kd apparent 949.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 980.0 nM
CSc1ccc2c(c1)-c1[nH]nc(NCc3c(C)cccc3Cl)c1C2 CHEMBL575078 pIC50 1000.0 nM
COc1cc2c(cc1OC)-c1[nH]nc(NCc3cccc(Cl)c3)c1C2 CHEMBL574006 pIC50 1000.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM