Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cc(F)cc(F)c2F)c2c(N)ncnc21 CHEMBL2171126 IC50 0.2 nM
Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(Cl)c2)c2c(N)ncnc21 CHEMBL2171122 IC50 0.2 nM
Cc1cccc(CC(=O)N2CCc3cc(-c4cn(C)c5ncnc(N)c45)ccc32)c1 CHEMBL2171144 IC50 0.2 nM
Cc1ccccc1CC(=O)N1CCc2cc(-c3cn(C)c4ncnc(N)c34)ccc21 CHEMBL2171143 IC50 0.2 nM
Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(F)c2)c2c(N)ncnc21 CHEMBL2171141 IC50 0.2 nM
Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cc(F)cc(C(F)(F)F)c2)c2c(N)ncnc21 CHEMBL2171125 IC50 0.3 nM
COc1cc2ncnc(Nc3ccc4c(c3)CCN4C(=O)Cc3cc(F)ccc3F)c2cc1OC CHEMBL3355039 pIC50 0.3981 nM
Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(C(F)(F)F)c2)c2c(N)ncnc21 CHEMBL2171124 IC50 0.4 nM
Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cc(F)ccc2F)c2c(N)ncnc21 CHEMBL2171139 IC50 0.4 nM
COc1cccc(CC(=O)N2CCc3cc(-c4cn(C)c5ncnc(N)c45)ccc32)c1 CHEMBL2171123 IC50 0.5 nM
Cn1cc(-c2ccc3c(c2F)CCN3C(=O)Cc2cccc(C(F)(F)F)n2)c2c(N)ncnc21 CHEMBL2441342 IC50 0.5 nM
Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(C(F)(F)F)n2)c2c(N)ncnc21 CHEMBL2441341 IC50 0.5 nM
Nc1ncnc2scc(-c3ccc4c(c3)CCN4C(=O)Cc3cc(F)ccc3F)c12 CHEMBL2171135 IC50 0.6 nM
COc1cc2ncnc(Nc3ccc4c(c3)CCN4C(=O)Cc3c(C)[nH]c4cc(F)ccc34)c2cc1OC CHEMBL3355038 pIC50 0.631 nM
Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2ccccc2F)c2c(N)ncnc21 CHEMBL2171140 IC50 0.7 nM
COc1cc2ncnc(Nc3ccc4c(c3)CCN4C(=O)Cc3c(C)[nH]c4ccccc34)c2cc1OC CHEMBL3355037 pIC50 0.7943 nM
Cc1cccc(CC(=O)N2CCc3c2ccc(-c2cn(C)c4ncnc(N)c24)c3F)n1 CHEMBL2441340 IC50 0.8 nM
Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2ccccc2Cl)c2c(N)ncnc21 CHEMBL2171121 IC50 0.9 nM
Nc1ncc(-c2cn[nH]c2)c2scc(-c3ccc4c(c3)CCN4C(=O)Cc3ccccc3)c12 CHEMBL2171131 IC50 0.9 nM
COc1cc2ncnc(Nc3ccc4c(c3F)CCN4C(=O)Cc3c(C)[nH]c4ccccc34)c2cc1OC CHEMBL3355046 pIC50 1.0 nM
CNc1ncc2ccc(Oc3cc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)ccc3C)cc2n1 CHEMBL3407849 IC50 1.0 nM
Cn1cc(-c2ccc3c(c2)CCN3CC(=O)c2cc(F)cc(C(F)(F)F)c2)c2c(N)ncnc21 CHEMBL3407846 IC50 1.0 nM
Nc1ncc(-c2ccncc2)c2scc(-c3ccc4c(c3)CCN4C(=O)Cc3ccccc3)c12 CHEMBL2171129 IC50 1.2 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc5c(c4)CCN5C(=O)Cc4ccccc4)csc23)cn1 CHEMBL2171132 IC50 1.3 nM
Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2ccc(F)cc2)c2c(N)ncnc21 CHEMBL2171142 IC50 1.5 nM
COc1cc2ncnc(Nc3ccc4c(c3)CCN4C(=O)Cc3c(C)[nH]c4c(F)cccc34)c2cc1OC CHEMBL3355040 pIC50 1.585 nM
Nc1ncc(C2CCNCC2)c2scc(-c3ccc4c(c3)CCN4C(=O)Cc3ccccc3)c12 CHEMBL2171130 IC50 1.9 nM
Cc1cc(C)n(CC(=O)N2CCc3cc(-c4cn(C)c5ncnc(N)c45)ccc32)n1 CHEMBL2441345 IC50 1.9 nM
Cc1nc(N)c2c(-c3ccc4c(c3)CCN4CC(=O)c3cc(F)cc(C(F)(F)F)c3)cn(C)c2n1 CHEMBL3407863 IC50 2.0 nM
CCc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 CHEMBL4857782 IC50 2.0 nM
Nc1nccc2scc(-c3ccc4c(c3)CCN4C(=O)Cc3cc(F)ccc3F)c12 CHEMBL2171134 IC50 2.5 nM
Cc1cccc(CC(=O)N2CCc3cc(-c4cn(C)c5ncnc(N)c45)ccc32)n1 CHEMBL2441339 IC50 2.5 nM
Cc1cc(C)n(CC(=O)N2CCc3c2ccc(-c2cn(C)c4ncnc(N)c24)c3F)n1 CHEMBL2441346 IC50 2.7 nM
CNc1ncc2ccc(Oc3cc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)ccc3N)cc2n1 CHEMBL3407850 IC50 3.0 nM
CNc1ncc2ccc(Oc3c(C)ccc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)c3N)cc2n1 CHEMBL3407504 IC50 3.0 nM
Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2CC2)c1 CHEMBL4869882 IC50 3.0 nM
Cc1cc(NC(=O)[C@H](O)c2cccc(Cl)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 CHEMBL4853221 IC50 3.0 nM
Cc1cccc([C@@H](O)C(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(C)c2)c1 CHEMBL4870780 IC50 3.0 nM
COc1cc2ncnc(Nc3ccc4c(c3)CCN4C(=O)Cn3c(C)cc4ccc(F)cc43)c2cc1OC CHEMBL3355041 pIC50 3.162 nM
Nc1ncc(-c2cccnc2)c2scc(-c3ccc4c(c3)CCN4C(=O)Cc3ccccc3)c12 CHEMBL2171128 IC50 3.2 nM
Cc1nc2ccc(-c3c(C)ccc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)c3N)cc2s1 CHEMBL3407856 IC50 4.0 nM
CNc1ncc2c(F)cc(Oc3c(C)ccc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)c3N)cc2n1 CHEMBL3407852 IC50 4.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)nc3)c2cc1OC CHEMBL3407848 IC50 4.0 nM
Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 CHEMBL4862478 IC50 4.0 nM
CCNC(=O)c1cc(-c2ccc(NC(=O)[C@H](O)c3cc(F)cc(F)c3)cc2C)cnc1N CHEMBL4863698 IC50 4.0 nM
Oc1cccc2cc(Nc3c(-c4ncccn4)oc4cnccc34)ccc12 CHEMBL1667910 IC50 4.1 nM
Cc1ncc2ccc(Oc3c(C)ccc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)c3N)cc2n1 CHEMBL3407854 IC50 5.0 nM
CNc1ncc2ccc(Oc3cc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)ccc3Cl)cc2n1 CHEMBL3407851 IC50 5.0 nM
Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)n1 CHEMBL4861671 IC50 5.0 nM
COc1cc2ncnc(Nc3ccc4c(c3)CCN4C(=O)Cc3c[nH]c4ccccc34)c2cc1OC CHEMBL3355043 pIC50 5.012 nM
Cn1nc(-c2ccc3c(c2)CCN3C(=O)Cc2cc(F)ccc2F)c2c(N)ncnc21 CHEMBL2171138 IC50 5.4 nM
Cc1ccc2cc(-c3c(C)ccc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)c3N)ccc2n1 CHEMBL3407862 IC50 6.0 nM
Cc1ccc(C(=O)c2c(-c3ccccc3)n(C)n(-c3ccccc3)c2=O)c(N)c1-c1ccc2nc(CF)sc2c1 CHEMBL3407859 IC50 6.0 nM
CNc1ncc2c(Cl)cc(Oc3c(C)ccc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)c3N)cc2n1 CHEMBL3407853 IC50 6.0 nM
CCc1cccc([C@@H](O)C(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(C)c2)c1 CHEMBL4858308 IC50 6.0 nM
COc1cc2ncnc(Nc3ccc4c(c3)CCN4C(=O)Cn3ccc4ccccc43)c2cc1OC CHEMBL3355042 pIC50 6.31 nM
Nc1ncnc2occ(-c3ccc4c(c3)CCN4C(=O)Cc3cc(F)ccc3F)c12 CHEMBL2171136 IC50 7.4 nM
CNC(=O)c1nc(-c2ccc(NC(=O)[C@H](O)c3cc(F)cc(F)c3)cc2C)cnc1N CHEMBL4848359 IC50 8.0 nM
Nc1nccc2occ(-c3ccc4c(c3)CCN4C(=O)Cc3cc(F)ccc3F)c12 CHEMBL2171137 IC50 8.1 nM
CNc1nc2ccc(-c3c(C)ccc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)c3N)cc2s1 CHEMBL3407857 IC50 9.0 nM
Cc1cc(NC(=O)[C@H](O)c2ccccc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 CHEMBL4870495 IC50 9.0 nM
CC(C)NC(=O)c1cc(-c2ccc(NC(=O)[C@H](O)c3cc(F)cc(F)c3)cc2Cl)cnc1N CHEMBL4848143 IC50 9.0 nM
COc1cc2ncnc(Nc3ccc4c(c3)CCN4C(=O)Cc3coc4ccccc34)c2cc1OC CHEMBL3355045 pIC50 10.0 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Cc4cc(F)ccc4F)cc3)c12 CHEMBL2171127 IC50 11.0 nM
Cc1ccc(C(=O)c2c(-c3ccccc3)n(C)n(-c3ccccc3)c2=O)c(N)c1-c1ccc2nc(C(F)F)sc2c1 CHEMBL3407860 IC50 11.0 nM
Cc1ccc(C(=O)c2c(-c3ccccc3)n(C)n(-c3ccccc3)c2=O)c(N)c1-c1ccc2nc(N)sc2c1 CHEMBL3407858 IC50 11.0 nM
Nc1nccc2scc(-c3ccc4c(c3)CCN4C(=O)Cc3ccccc3)c12 CHEMBL2171133 IC50 11.7 nM
CNC(=O)c1cc(-c2ccc(NC(=O)[C@H](O)c3cc(F)cc(F)c3)cc2C)cnc1N CHEMBL4875875 IC50 14.0 nM
CN1CCN(Cc2cnc(-c3oc4cnccc4c3Nc3ccc4c(O)cccc4c3)nc2)CC1 CHEMBL1667911 IC50 16.0 nM
Cc1ccnn1CC(=O)N1CCc2cc(-c3cn(C)c4ncnc(N)c34)ccc21 CHEMBL2441344 IC50 16.6 nM
CC(C)NC(=O)c1cc(-c2ccc(NC(=O)[C@H](O)c3cc(F)cc(F)c3)cc2F)cnc1N CHEMBL4851480 IC50 17.0 nM
Cc1ccc(CC(=O)N2CCc3cc(-c4cn(C)c5ncnc(N)c45)ccc32)cc1 CHEMBL2171145 IC50 17.0 nM
O/N=C1\NCc2cc(Nc3c(-c4ncccn4)oc4cnccc34)ccc21 CHEMBL1667899 IC50 18.0 nM
Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)OC(C)C)c1 CHEMBL4870100 IC50 19.0 nM
Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2ccccn2)c2c(N)ncnc21 CHEMBL2441336 IC50 19.1 nM
CC(C)NC(=O)c1cc(-c2ccc(NC(=O)[C@H](O)c3cc(F)cc(F)c3)cc2)cnc1N CHEMBL4846663 IC50 23.0 nM
Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccnc2)c2c(N)ncnc21 CHEMBL2441337 IC50 23.4 nM
Cc1cc(NC(=O)[C@@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 CHEMBL4852735 IC50 26.0 nM
Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cncc(C(=O)NC(C)C)c1 CHEMBL4854504 IC50 27.0 nM
CCOC(=O)c1oc2cnccc2c1Nc1ccc2c(c1)CC/C2=N/O CHEMBL1667925 IC50 30.0 nM
Oc1cc(Nc2c(-c3ncccn3)oc3cnccc23)ccc1Cl CHEMBL1614963 IC50 31.0 nM
Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)(C)C)c1 CHEMBL4876496 IC50 33.0 nM
O=C(Nc1ccncn1)c1oc2cnccc2c1Nc1ccc2c(O)cccc2c1 CHEMBL1614960 IC50 37.9 nM
CNc1ncc2cc(-c3c(C)ccc(C(=O)Nc4ccc(OC)c(C(F)(F)F)c4)c3N)ccc2n1 CHEMBL3407847 IC50 41.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)c4c(-c5ccncc5)n(C)n(-c5ccccc5)c4=O)nc3)c2cc1OC CHEMBL3407864 IC50 42.0 nM
Cc1ccc(C(=O)c2c(-c3ccccc3)n(C)n(-c3ccccc3)c2=O)c(N)c1-c1ccc2nc(C(F)(F)F)sc2c1 CHEMBL3407861 IC50 53.0 nM
CCOC(=O)c1oc2cnccc2c1Nc1ccc2c(O)cccc2c1 CHEMBL1667906 IC50 54.0 nM
Cc1ccn(CC(=O)N2CCc3cc(-c4cn(C)c5ncnc(N)c45)ccc32)n1 CHEMBL2441343 IC50 57.5 nM
Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2ccncc2)c2c(N)ncnc21 CHEMBL2441338 IC50 63.8 nM
Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(C)c(C(=O)NC(C)C)c1 CHEMBL4849149 IC50 68.0 nM
Cc1cc(NC(=O)Cc2ccccc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 CHEMBL4866245 IC50 73.0 nM
Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1ccc(N)nc1 CHEMBL4853611 IC50 75.0 nM
COc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 CHEMBL4870565 IC50 85.0 nM
CC(C)NC(=O)c1oc2cnccc2c1Nc1ccc2c(O)cccc2c1 CHEMBL1667908 IC50 86.7 nM
CN(C)/C=C/NC(=O)c1oc2cnccc2c1Nc1ccc2c(O)cccc2c1 CHEMBL1667909 IC50 102.0 nM
CNc1ncc(-c2ccc(NC(=O)[C@H](O)c3cc(F)cc(F)c3)cc2C)cc1C(=O)NC(C)C CHEMBL4858598 IC50 129.0 nM
Cc1cc(NC(=O)[C@](C)(O)c2ccccc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 CHEMBL4868021 IC50 130.0 nM
CCc1n[nH]c2c(Cl)ccc(Nc3c(-c4ncccn4)oc4cnccc34)c12 CHEMBL1667923 IC50 140.0 nM
CCOC(=O)c1oc2cnccc2c1Nc1ccc2c(O)c(F)ccc2c1 CHEMBL1667907 IC50 142.0 nM
Cc1cc(NC(=O)[C@@](C)(O)c2ccccc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 CHEMBL4848921 IC50 159.0 nM
Cc1nc2cc(-c3c(C)ccc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)c3N)ccc2s1 CHEMBL3407855 IC50 240.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1onc(C(=O)N[C@@H](CN)c3ccccc3)c1CC2(C)C CHEMBL3985355 IC50 240.0 nM
Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)O)c1 CHEMBL4865268 IC50 241.0 nM
Clc1ccc(Nc2c(-c3ncccn3)oc3cnccc23)c2cn[nH]c12 CHEMBL1667916 IC50 250.0 nM
COc1cc2ncnc(Nc3ccc4c(c3)CCN4C(=O)Cc3ccn(C)n3)c2cc1OC CHEMBL3355044 pIC50 251.19 nM
Cc1cc(Nc2c(-c3ncccn3)oc3cnccc23)c2cn[nH]c2c1Cl CHEMBL1667922 IC50 300.0 nM
OCCCc1n[nH]c2c(Cl)ccc(Nc3c(-c4ncccn4)oc4cnccc34)c12 CHEMBL1667924 IC50 350.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1noc(C(N)=O)c1C(C)(C)C2 CHEMBL3943051 IC50 400.0 nM
CCOC(=O)c1oc2cnccc2c1Nc1ccc(Cl)c(O)c1 CHEMBL1667912 IC50 442.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1onc(C(N)=O)c1CC2(C)C CHEMBL3969481 IC50 510.0 nM
O=C(Nc1ncccn1)c1oc2cnccc2c1Nc1ccc(Cl)c(O)c1 CHEMBL1667914 IC50 556.0 nM
Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)N(C)C)c1 CHEMBL4876223 IC50 599.0 nM
C=CC(=O)N1CCN(CCCn2c(=O)c(-c3c(Cl)c(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)CC1 CHEMBL4068509 IC50 792.0 nM
O=C1CCc2cc(Nc3c(-c4ncccn4)oc4cnccc34)ccc21 CHEMBL1667897 IC50 820.0 nM
CC(C)NC(=O)c1oc2cnccc2c1Nc1ccc(Cl)c(O)c1 CHEMBL1667913 IC50 823.0 nM
Cc1ccc(Nc2c(-c3ncccn3)oc3cnccc23)c2cn[nH]c12 CHEMBL1667920 IC50 840.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM