CC(C)c1cccc2c1C(=O)C(COC(=O)c1c(Cl)ccc(S(=O)(=O)N3CCN(C)CC3)c1Cl)S2(=O)=O CHEMBL553298 Ki 0.007 nM
CC(C)c1cccc2c1C(=O)C(COC(=O)c1c(Cl)ccc(OCCN3CCOCC3)c1Cl)S2(=O)=O CHEMBL539031 Ki 0.008 nM
CC(C)c1cccc2c1C(=O)N(COC(=O)c1c(Cl)ccc(OCCN3CCOCC3)c1Cl)S2(=O)=O CHEMBL162877 Ki 0.008 nM
CC(C)c1cccc2c1C(=O)C(COC(=O)c1c(Cl)ccc(S(=O)(=O)N(C)CCN(C)C)c1Cl)S2(=O)=O CHEMBL538776 Ki 0.01 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC(=O)c1c(Cl)ccc(OCC(=O)O)c1Cl)C2=O CHEMBL163414 Ki 0.011 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC(=O)c1c(Cl)ccc(S(=O)(=O)N3CCN(C)CC3)c1Cl)C2=O CHEMBL348965 Ki 0.011 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC1=C(Cc3ccccc3)C(=O)OC1)C2=O CHEMBL142100 Ki 0.013 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC(=O)c1c(Cl)ccc(OCCN3CCOCC3)c1Cl)C2=O CHEMBL114992 Ki 0.013 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC(=O)c1c(Cl)ccc(S(=O)(=O)N(C)CCN(C)C)c1Cl)C2=O CHEMBL164352 Ki 0.013 nM
CC(C)[C@@H]1C(=O)N(S(C)(=O)=O)[C@@H]2CCN(C(=O)c3cnc(CNC4CC4)cn3)[C@H]21 CHEMBL543416 Ki 0.014 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC(=O)c1c(Cl)ccc(OCCN3CCCC3)c1Cl)C2=O CHEMBL435666 Ki 0.014 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC1=C(Cc3ccccc3)C(=O)OC1C)C2=O CHEMBL140865 Ki 0.016 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC1=C(c3ccccc3)C(=O)OC1C)C2=O CHEMBL142526 Ki 0.021 nM
CCOc1cc(OC)cc2c1C(=O)N(COC(=O)c1c(Cl)ccc(OCCN3CCOCC3)c1Cl)S2(=O)=O CHEMBL12082 Ki 0.022 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC(=O)c1c(Cl)cccc1Cl)C2=O CHEMBL115827 Ki 0.023 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COc1cc(C)oc(=O)c1Cl)C2=O CHEMBL344940 Ki 0.025 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC1=C(c3ccccc3)C(=O)OC1)C2=O CHEMBL142099 Ki 0.025 nM
Cc1cccc(Cc2nnc(C(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)OCc3ccccc3)C(C)C)C(C)C)o2)c1 CHEMBL285231 Ki 0.025 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COc1cc(C)oc(=O)c1C(=O)c1ccccc1)C2=O CHEMBL356043 Ki 0.027 nM
CC(C)c1cccc2c1C(=O)N(COC(=O)c1c(Cl)cccc1Cl)S2(=O)=O CHEMBL314218 Ki 0.03 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC1=C(Cl)C(=O)OC1)C2=O CHEMBL143819 Ki 0.03 nM
CC(C)c1cc(F)cc2c1C(=O)N(COC(=O)c1c(Cl)cccc1Cl)S2(=O)=O CHEMBL325155 Ki 0.03 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC1=CC(=O)C1)C2=O CHEMBL142960 Ki 0.033 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC1=C(Cc3ccccc3)C(=O)CC1)C2=O CHEMBL357694 Ki 0.034 nM
CCC[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CNC(=O)c2ccc(O)cc2)CNC(=O)[C@H](CS(=O)(=O)[O-])NC(=O)/C=C/c2csc(n2)[C@H](Cc2ccc(O)cc2)NC(=O)C(=O)[C@H]([C@@H](C)CC)NC1=O CHEMBL4204851 IC50 0.034 nM
CCOP(=O)(OCC)OCN1C(=O)c2c(C(C)C)cc(OC)cc2S1(=O)=O CHEMBL41327 Ki 0.035 nM
C=CC[C@H]1C(=O)N(S(=O)(=O)c2ccc3ccccc3c2)[C@H]2CCN(C(=O)OCc3ccccc3)[C@H]12 CHEMBL2367667 IC50 0.036 nM
CCOc1nc2cccc(CC)c2c(=O)o1 CHEMBL79428 pKi 0.04266 nM
C=CC[C@H]1C(=O)N(S(C)(=O)=O)[C@H]2CCN(C(=O)OCc3ccccc3)[C@H]12 CHEMBL2367632 IC50 0.047 nM
CCOc1cc(OC)cc2c1C(=O)N(COC(=O)c1c(Cl)cccc1Cl)S2(=O)=O CHEMBL11558 Ki 0.049 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COc1cc(C)oc(=O)c1)C2=O CHEMBL143136 Ki 0.05 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC1=CC(=O)OC1)C2=O CHEMBL343599 Ki 0.052 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COc1nc3ccccn3c(=O)c1Br)C2=O CHEMBL142579 Ki 0.058 nM
CCC(C)c1cccc2c1C(=O)N(COC(=O)c1c(Cl)cccc1Cl)S2(=O)=O CHEMBL91944 Ki 0.06 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC1=C(C)C(=O)CC1)C2=O CHEMBL142288 Ki 0.06 nM
COC(=O)c1ccc2oc(C(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)c3ccc(NC(=O)NS(=O)(=O)c4ccc(Cl)cc4)cc3)C(C)C)C(C)C)nc2c1 CHEMBL339307 Ki 0.06 nM
CC(C)[C@H](NC(=O)c1ccc(C(=O)NS(=O)(=O)c2ccccc2)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)C(=O)NCCc1ccccc1)C(C)C CHEMBL320942 Ki 0.06 nM
COC(=O)c1ccc2nc(C(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)c3ccc(NC(=O)NS(=O)(=O)c4ccc(Cl)cc4)cc3)C(C)C)C(C)C)oc2c1 CHEMBL403098 Ki 0.06 nM
CC1=C(C#N)[C@@H](c2ccc(C#N)cc2S(C)(=O)=O)N(C)C(=O)N1c1cccc(C(F)(F)F)c1 CHEMBL3617973 IC50 0.065 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COc1nc3ccccn3c(=O)c1Cl)C2=O CHEMBL344750 Ki 0.066 nM
CCOc1nc2cccc(CBr)c2c(=O)o1 CHEMBL344066 pKi 0.06761 nM
CCOP(=O)(OCC)OCN1C(=O)c2c(C(C)CC)cccc2S1(=O)=O CHEMBL41881 Ki 0.07 nM
CCOc1cc(OCC)c2c(c1)S(=O)(=O)N(COC(=O)c1c(Cl)ccc(OCCN3CCOCC3)c1Cl)C2=O CHEMBL430157 Ki 0.07 nM
CCOc1nc2cccc(C(C)C)c2c(=O)o1 CHEMBL356120 pKi 0.07079 nM
CCc1cccc2c1C(=O)N(COC(=O)c1c(Cl)cccc1Cl)S2(=O)=O CHEMBL432049 Log Ki 0.07079 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COc1cc(=O)n3ccccc3n1)C2=O CHEMBL434320 Ki 0.078 nM
COc1cc(OC)c2c(c1)S(=O)(=O)N(COC(=O)c1c(Cl)cccc1Cl)C2=O CHEMBL12051 Ki 0.08 nM
CCOc1cc(OCC)c2c(c1)S(=O)(=O)N(COC(=O)c1c(Cl)cccc1Cl)C2=O CHEMBL11874 Ki 0.08 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC1=CC(=O)c3ccccc31)C2=O CHEMBL141329 Ki 0.083 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COc1cc(=O)oc3ccccc13)C2=O CHEMBL142555 Ki 0.09 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC1=CC(=O)OC1C)C2=O CHEMBL143417 Ki 0.093 nM
CCOc1nc2c(C)ccc(C)c2c(=O)o1 CHEMBL145002 pKi 0.0955 nM
CCOP(=O)(OCC)OCN1C(=O)c2c(C(C)C)cccc2S1(=O)=O CHEMBL288810 Ki 0.1 nM
COC(=O)c1ccc2oc(C(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)c3ccc(C(=O)NS(=O)(=O)c4ccc(Cl)cc4)cc3)C(C)C)C(C)C)nc2c1 CHEMBL405664 Ki 0.1 nM
CC(SC(=O)c1cccs1)C(=O)NCC(=O)N1CSCC1C(=O)O CHEMBL293138 IC50 0.1 nM
COC(=O)c1ccc2nc(C(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)c3ccc(C(=O)NS(=O)(=O)c4ccc(Cl)cc4)cc3)C(C)C)C(C)C)oc2c1 CHEMBL334978 Ki 0.1 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COc1cc(=O)n3c(n1)CCCC3)C2=O CHEMBL143365 Ki 0.11 nM
CCOc1cc(OCC)c2c(c1)S(=O)(=O)N(COC(=O)c1c(Cl)ccc(OCCN3CCCC3)c1Cl)C2=O CHEMBL269223 Ki 0.11 nM
CCOc1nc2cccc(C)c2c(=O)o1 CHEMBL81249 pKi 0.1148 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC1=CC(=O)N(Cc3ccccc3)C1)C2=O CHEMBL343281 Ki 0.14 nM
CC(C)[C@@H]1C(=O)N(S(C)(=O)=O)[C@@H]2CCN(C(=O)c3coc(CN4CCCC4)n3)[C@H]21 CHEMBL542949 Ki 0.16 nM
CCOc1cccc2c1C(=O)N(COC(=O)c1c(Cl)cccc1Cl)S2(=O)=O CHEMBL11758 Ki 0.17 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COC1=C(C)C(=O)CCC1)C2=O CHEMBL422298 Ki 0.18 nM
C/C=C/c1cccc2nc(OCC)oc(=O)c12 CHEMBL145774 pKi 0.1905 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)cc1)C(C)C)C(=O)c1nc2cc(C(N)=O)ccc2o1 CHEMBL419985 Ki 0.2 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(NC(=O)NS(=O)(=O)c2ccc(Cl)cc2)cc1)C(C)C)C(=O)c1nc2ccccc2o1 CHEMBL336779 Ki 0.2 nM
CCCc1c(OC)c(OC)cc2c1C(=O)N(CSc1nnnn1-c1ccccc1)S2(=O)=O CHEMBL112575 Ki 0.2 nM
CC(C)c1cc(O)cc2c1C(=O)N(COC(=O)c1c(Cl)ccc(S(=O)(=O)N3CCN(C)CC3)c1Cl)S2(=O)=O CHEMBL162863 Ki 0.2 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)cc1)C(C)C)C(=O)c1nc2ccc(C(N)=O)cc2o1 CHEMBL270680 Ki 0.2 nM
CC(C)C(NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)cc1)C(C)C)C(=O)C(F)(F)F CHEMBL293809 Ki 0.2 nM
CC(C)c1cccc2c1C(=O)N(COc1nc3ccccn3c(=O)c1Cl)S2(=O)=O CHEMBL356732 Ki 0.21 nM
CC(C)C(NC(=O)Cn1c(-c2ccc(F)cc2)ncc(NS(=O)(=O)C2CCCCC2)c1=O)B1OC(C)(C)C(C)(C)O1 CHEMBL11099 Ki 0.21 nM
CNC(=O)c1cc(-c2ccnn2-c2ccc(C#N)cc2)c(C)n(-c2cccc(C(F)(F)F)c2)c1=O CHEMBL3617966 IC50 0.21 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COc1cc(=O)sc3ccccc13)C2=O CHEMBL341905 Ki 0.22 nM
CCCc1cccc2nc(OCC)oc(=O)c12 CHEMBL357464 pKi 0.2291 nM
CC(C)Oc1cccc2c1C(=O)N(COC(=O)c1c(Cl)cccc1Cl)S2(=O)=O CHEMBL11913 Ki 0.24 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COc1nc3ccccn3c(=O)c1C)C2=O CHEMBL356962 Ki 0.25 nM
CC1=C(C#N)[C@@H](c2ccc(C#N)cc2S(C)(=N)=O)N(C)C(=O)N1c1cccc(C(F)(F)F)c1 CHEMBL4744163 IC50 0.25 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(CSc1nnnn1-c1ccccc1)C2=O CHEMBL98422 Ki 0.27 nM
COC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](B(O)O)C(C)C)C(C)C CHEMBL5280380 IC50 0.27 nM
COC(=O)c1ccc2oc(C(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)c3ccc(NS(=O)(=O)C(F)(F)F)cc3)C(C)C)C(C)C)nc2c1 CHEMBL130966 Ki 0.3 nM
CC(C)c1cccc2c1C(=O)N(CSc1nnnn1-c1ccccc1)S2(=O)=O CHEMBL50974 Ki 0.3 nM
[C-]#[N+]C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N[C@@H]1c1ccc(C#N)cc1[S@+](C)[O-] CHEMBL4110495 IC50 0.3 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N(C)Cc1cn[nH]c1 CHEMBL3912018 IC50 0.3 nM
CC(C)[C@@H]1C(=O)N(S(C)(=O)=O)[C@@H]2CCN(C(=O)/C=C/CN3CCCCC3)[C@H]21 CHEMBL2368616 Ki 0.31 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)cc1)C(C)C)C(=O)c1nc2ccccc2o1 CHEMBL127714 Ki 0.33 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)OC(C)(C)C)cc1)C(C)C)C(=O)c1nc2ccccc2o1 CHEMBL262516 Ki 0.34 nM
CCCOc1cc(OC)cc2c1C(=O)N(COC(=O)c1c(Cl)cccc1Cl)S2(=O)=O CHEMBL274582 Ki 0.34 nM
CCC1(CC)C(=O)N(c2ccc(CSc3nc4ccccc4o3)cc2)C1=O CHEMBL567956 Ki 0.34 nM
COC(=O)c1ccc2oc(C(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)c3ccc(S(N)(=O)=O)cc3)C(C)C)C(C)C)nc2c1 CHEMBL337931 Ki 0.35 nM
CCCCOC(=O)NCC(F)(F)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)Oc1ccccc1)C(C)C)C(C)C CHEMBL108477 Ki 0.35 nM
CC(C)[C@H](NC(=O)Oc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)CNC(=O)c1cccnc1)C(C)C CHEMBL106592 Ki 0.35 nM
COc1ccc(C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)C(F)(F)CNCc2ccccc2)C(C)C)C(C)C)cc1 CHEMBL110443 Ki 0.35 nM
COc1ccc(C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)C(F)(F)CNCc2ccccc2)C(C)C)C(C)C)cc1 CHEMBL432539 Ki 0.35 nM
COC(=O)c1ccc2nc(C(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)c3ccc(S(N)(=O)=O)cc3)C(C)C)C(C)C)oc2c1 CHEMBL404910 Ki 0.35 nM
COC(=O)c1ccc2oc(C(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)OCc3ccccc3)C(C)C)C(C)C)nc2c1 CHEMBL111029 Ki 0.37 nM
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)C(N)=O)C(C)C CHEMBL302961 Ki 0.38 nM
CC(C)[C@H](NC(=O)Oc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)CNC(=O)OC(C)(C)C)C(C)C CHEMBL306202 Ki 0.39 nM
CCOc1nc2cc(OC)cc(C)c2c(=O)o1 CHEMBL347760 pKi 0.3981 nM
CC(C)C(NC(=O)c1ccc(C(=O)NS(=O)(=O)c2ccc(Br)cc2)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C CHEMBL3085439 Ki 0.4 nM
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)C(=O)NCc1ccccc1)C(C)C CHEMBL165759 Ki 0.4 nM
CC(C)C(NC(=O)C1CCCN1C(=O)[C@@H](NC(=O)c1ccc(Oc2ccccc2)cc1)C(C)C)C(=O)C(F)(F)F CHEMBL56136 Ki 0.41 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)c1nc2cc(CO[Si](C)(C)C(C)(C)C)ccc2o1 CHEMBL339650 Ki 0.43 nM
CCOC(=O)c1ccc(/C=C/C(=O)N[C@H](C(=O)N2CCCC2C(=O)NC(C(=O)C(F)(F)F)C(C)C)C(C)C)cc1 CHEMBL55912 Ki 0.43 nM
CC(C)(CS(=O)(=O)c1ccc(OC(=O)C(C)(C)c2ccc(C(C)(C)C(=O)Oc3ccc(S(=O)(=O)CC(C)(C)C(=O)O)cc3)cc2)cc1)C(=O)O CHEMBL56605 Ki 0.45 nM
CCC[C@@H](NC(=O)N1C(=O)C(CC)(CC)[C@@H]1Oc1ccc(C(=O)N2CCN(C)CC2)cc1)c1ccc2c(c1)OCO2 CHEMBL310871 IC50 0.45 nM
[C-]#[N+]C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(CC(N)=O)[C@@H]1c1ccc(C#N)cc1S(C)(=O)=O CHEMBL4107034 IC50 0.45 nM
CCOc1nc2cccc(C(Br)Br)c2c(=O)o1 CHEMBL145592 pKi 0.4677 nM
COc1ccc2c(c1)S(=O)(=O)N(COC(=O)c1c(Cl)cccc1Cl)C2=O CHEMBL274347 Ki 0.47 nM
Cc1cccc(Cc2nc(C(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)OCc3ccccc3)C(C)C)C(C)C)no2)c1 CHEMBL24058 Ki 0.49 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COc1cc(=O)n(C)c3ccccc13)C2=O CHEMBL139568 Ki 0.5 nM
CC(C)[C@H](NC(=O)c1ccc(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C CHEMBL340818 Ki 0.5 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NS(=O)(=O)c2ccccc2)cc1)C(C)C)C(=O)c1nc2ccccc2o1 CHEMBL127615 Ki 0.5 nM
CCC1(CC)C(=O)N(c2ccc(CSc3nc4ccccc4s3)nc2)C1=O CHEMBL578586 Ki 0.5 nM
Cc1c([S+]([O-])c2ccc(C#N)cc2)cc(C(=O)NCCCN2CCCC2=O)c(=O)n1-c1cccc(C(F)(F)F)c1 CHEMBL3617965 IC50 0.5 nM
[C-]#[N+]C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N[C@@H]1c1ccc(C#N)cc1S(C)(=O)=O CHEMBL4107106 IC50 0.5 nM
CC(C)C(NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)cc1)C(C)C)C(N)=O CHEMBL5200257 Ki 0.5 nM
CC(C)(O)CNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)[C@H]1c1ccc(C#N)cc1 CHEMBL4112323 IC50 0.5 nM
CC(C)[C@H](NC(=O)Cn1c(-c2ccc(F)cc2)ncc(N)c1=O)C(=O)c1nnc(C(C)(C)c2ccccc2)o1 CHEMBL277672 Ki 0.52 nM
COC(=O)c1ccc2nc(C(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)OCc3ccccc3)C(C)C)C(C)C)oc2c1 CHEMBL273818 Ki 0.55 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)C1=NCCO1 CHEMBL354832 Ki 0.55 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(NC(=O)NS(=O)(=O)c2ccccc2)cc1)C(C)C)C(=O)c1nc2ccccc2o1 CHEMBL128499 Ki 0.6 nM
COc1cc(OC)c2c(c1)S(=O)(=O)N(CSc1nnnn1-c1ccccc1)C2=O CHEMBL319723 Ki 0.6 nM
CCC(C)c1cccc2c1C(=O)N(CSc1nnnn1-c1ccccc1)S2(=O)=O CHEMBL50830 Ki 0.6 nM
COC(=O)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(C)C CHEMBL166401 Ki 0.6 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)C1NCCO1 CHEMBL2205678 Ki 0.6 nM
CC(C)[C@H](NC(=O)Oc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C CHEMBL2372974 Ki 0.63 nM
Cc1cccc(Cc2nnc(C(=O)[C@@H](NC(=O)Cn3c(-c4ccc(F)cc4)ncc(N)c3=O)C(C)C)o2)c1 CHEMBL283168 Ki 0.64 nM
COC(=O)c1ccc2nc(C(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)Oc3ccccc3)C(C)C)C(C)C)oc2c1 CHEMBL323030 Ki 0.64 nM
COC(=O)c1ccc2oc(C(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)Oc3ccccc3)C(C)C)C(C)C)nc2c1 CHEMBL108622 Ki 0.64 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)cc1)C(C)C)C(=O)c1nc2cc(C(=O)O)ccc2o1 CHEMBL419800 Ki 0.65 nM
COC(=O)c1ccc2oc(C(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)c3ccc(OC)cc3)C(C)C)C(C)C)nc2c1 CHEMBL107936 Ki 0.65 nM
COc1ccc(C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)C(F)(F)C(N)=O)C(C)C)C(C)C)cc1 CHEMBL68311 Ki 0.65 nM
COc1ccc2oc(C(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)c3ccc(C(=O)NS(=O)(=O)c4ccc(Cl)cc4)cc3)C(C)C)C(C)C)nc2c1 CHEMBL337968 Ki 0.66 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)cc1)C(C)C)C(=O)c1nc2cc(CO)ccc2o1 CHEMBL127780 Ki 0.66 nM
COc1ccc2nc(C(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)c3ccc(C(=O)NS(=O)(=O)c4ccc(Cl)cc4)cc3)C(C)C)C(C)C)oc2c1 CHEMBL256466 Ki 0.66 nM
C=CC[C@H]1C(=O)N(C(C)=O)[C@H]2CCN(C(=O)OCc3ccccc3)[C@H]12 CHEMBL2367646 IC50 0.69 nM
CCCc1cccc2c1C(=O)N(CSc1nnnn1-c1ccccc1)S2(=O)=O CHEMBL299656 Ki 0.7 nM
CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(-c3ccccc3)n(CC(=O)NC(C(=O)C(F)(F)F)C(C)C)c2=O)cc1 CHEMBL307315 Ki 0.7 nM
CCC1CCCC2=C1C(=O)N(COC(=O)c1c(Cl)cccc1Cl)S2(=O)=O CHEMBL326848 Ki 0.7 nM
CCC1(CC)C(=O)N(c2ccc(OC)cc2)C1=O CHEMBL408130 Ki 0.71 nM
CCC(C)c1cccc2c1C(=O)N(COc1nc3ccccn3c(=O)c1Cl)S2(=O)=O CHEMBL342725 Ki 0.72 nM
C/C=C1\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C/C(C)=C/Cl)[C@@H](C)CC)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O CHEMBL5284383 IC50 0.73 nM
CC(C)c1cccc2c1C(=O)N(COc1ccc(S(=O)(=O)N3CCOCC3)cc1Cl)S2(=O)=O CHEMBL109234 Ki 0.8 nM
O=C(OCN1C(=O)C2=C(C3CCC2C3)S1(=O)=O)c1c(Cl)cccc1Cl CHEMBL326847 Ki 0.8 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)cc1)C(C)C)C(=O)c1nc2cc(O)ccc2o1 CHEMBL128553 Ki 0.81 nM
CC(C)[C@H](NC(=O)Oc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)CN)C(C)C CHEMBL110125 Ki 0.81 nM
CC(C)[C@H](NC(=O)Oc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)CN)C(C)C CHEMBL66128 Ki 0.81 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)cc1)C(C)C)C(=O)c1nc2ccc(O)cc2o1 CHEMBL404871 Ki 0.81 nM
CCC1(CC)C(=O)N(c2ccc(CSc3nc4ccccc4s3)cc2)C1=O CHEMBL567748 Ki 0.82 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COc1cc(C)n(C)c(=O)c1)C2=O CHEMBL143425 Ki 0.85 nM
CNC(=O)C(F)(F)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)Oc1ccccc1)C(C)C)C(C)C CHEMBL304114 Ki 0.85 nM
CCCCC1(CC)C(=O)N(c2ccccc2)C1=O CHEMBL566476 Ki 0.85 nM
C/C=C1\NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CCCCC)[C@@H](C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2C(=O)[C@H](CC[C@H]2O)NC1=O CHEMBL398726 IC50 0.85 nM
CC(C)C(NC(=O)C1CCCN1C(=O)[C@@H](NC(=O)c1ccc2ccccc2c1)C(C)C)C(=O)C(F)(F)F CHEMBL56469 Ki 0.87 nM
COc1cc(C(C)C)c2c(c1)S(=O)(=O)N(COc1nc3ccccn3c(=O)c1Cc1ccccc1)C2=O CHEMBL143215 Ki 0.9 nM
CC1=C(C(=O)OCCOCC(=O)O)[C@@H](c2ccc(C#N)cc2)N(CC(=O)O)C(=O)N1c1cccc(C(F)(F)F)c1 CHEMBL3617970 IC50 0.9 nM
[C-]#[N+]C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C(=O)N2CCN(c3ccccn3)CC2)[C@@H]1c1ccc(C#N)cc1S(C)(=O)=O CHEMBL4112397 IC50 0.9 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)cc2c(=O)n(C(C)(C)Cc3ccccc3)c(=O)[nH]c2c1=O)C(=O)C(F)(F)F CHEMBL276307 Ki 0.93 nM
CCSc1nc2cccc(C)c2c(=O)o1 CHEMBL144906 pKi 0.9333 nM
CCc1cccc2nc(NC(C)C)oc(=O)c12 CHEMBL145550 pKi 0.9333 nM
Cc1cncc(C)c1COC(=O)Nc1cnc(-c2ccc(F)cc2)n(CC(=O)NC(B2OC(C)(C)C(C)(C)O2)C(C)C)c1=O CHEMBL442524 Ki 0.96 nM
CC(=O)N(CC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)C(C)C)Cc1ccccc1 CHEMBL2372979 Ki 0.96 nM
O=C(OCN1C(=O)c2c(-c3ccccc3)cccc2S1(=O)=O)c1c(Cl)cccc1Cl CHEMBL421162 Ki 1.0 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)c1nc2cc(C(=O)ON)ccc2o1 CHEMBL131580 Ki 1.0 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1)C(=O)C(F)(F)F CHEMBL336171 Ki 1.0 nM
CCC[C@H]1C(=O)N(S(=O)(=O)c2ccc3ccccc3c2)[C@H]2CCN(C(=O)CCN3CCCCC3)[C@H]12 CHEMBL2368613 IC50 1.0 nM
CC1(C)CCCC2=C1C(=O)N(COC(=O)c1c(Cl)cccc1Cl)S2(=O)=O CHEMBL114017 Ki 1.0 nM
Cc1ccc(C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)C(C)C)cc1C CHEMBL2372968 Ki 1.0 nM
CC(C)C1CCCC2=C1C(=O)N(COC(=O)c1c(Cl)cccc1Cl)S2(=O)=O CHEMBL112119 Ki 1.0 nM
CC1CCCC2=C1C(=O)N(COC(=O)c1c(Cl)cccc1Cl)S2(=O)=O CHEMBL326136 Ki 1.0 nM
CCC1(CC)C(=O)N(c2ccc(CSc3nc4cc(C(=O)O)ccc4o3)cc2)C1=O CHEMBL568217 Ki 1.0 nM
CN(C)CCNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3900281 EC50 1.0 nM
C[S+]([O-])CCNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3901565 EC50 1.0 nM
CN1CC(NC(=O)N2C(=O)N(c3cccc(C(F)(F)F)c3)C3=C(C(=O)CC3)C2c2ccc(C#N)cc2)CC1=O CHEMBL3902673 EC50 1.0 nM
N#Cc1ccc([C@@H]2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C(=O)NCCO)cc1 CHEMBL4111285 EC50 1.0 nM
C[C@H](O)CNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3911341 EC50 1.0 nM
CCNC(=O)N1C(=O)N(c2cccc(C(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3920727 EC50 1.0 nM
CS(=O)(=O)c1cc(C#N)ccc1[C@H]1NC(=O)N(c2cccc(C(F)(F)F)c2)C2=C1C(=O)CC2 CHEMBL4112385 EC50 1.0 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)[C@H]1c1ccc(C#N)cc1S(C)(=O)=O CHEMBL4115072 EC50 1.0 nM
N#Cc1ccc([C@@H]2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C(=O)NC2CCS(=N)(=O)CC2)cc1 CHEMBL4113393 EC50 1.0 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C(=O)N[C@H]2COC[C@H]2O)cc1 CHEMBL3966576 EC50 1.0 nM
CC(C)NC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)[C@H]1c1ccc(C#N)cc1S(C)(=O)=O CHEMBL4112429 EC50 1.0 nM
CC(C)(O)CNC(=O)N1C(=O)N(c2cccc(C(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3895383 EC50 1.0 nM
CN1C(=O)N(c2ccnc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1S(C)(=O)=O CHEMBL3945540 EC50 1.0 nM
CCS(=O)(=O)c1cc(C#N)ccc1[C@H]1NC(=O)N(c2cccc(C(F)(F)F)c2)C2=C1C(=O)CC2 CHEMBL4114363 EC50 1.0 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)[C@H]1c1ccc(C#N)cc1[S+](C)[O-] CHEMBL4110957 EC50 1.0 nM
CN(CCO)C(=O)CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1S(C)(=O)=O CHEMBL3951082 EC50 1.0 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NC12CC(C1)C2 CHEMBL3937897 IC50 1.0 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NCc1ccccc1 CHEMBL3890240 IC50 1.0 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N(C)CCOC CHEMBL3902557 IC50 1.0 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NC1CCN(C)CC1 CHEMBL3917970 IC50 1.0 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NC1CCS(=O)(=O)C1 CHEMBL3959854 IC50 1.0 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CC[C@H](N(C)C)C1 CHEMBL3944811 IC50 1.0 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NCC(=O)N1CCOCC1 CHEMBL3900712 IC50 1.0 nM
CS(=O)(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1CC(=O)N1CCOCC1 CHEMBL3911507 IC50 1.0 nM
COCCCN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1S(C)(=O)=O CHEMBL3902357 IC50 1.0 nM
C[C@@H](O)CNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL4111813 IC50 1.0 nM
CS(=O)(=O)CCNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1F CHEMBL3973301 IC50 1.0 nM
CNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1OC CHEMBL3941510 IC50 1.0 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(=O)(=NC#N)C(C)C)cc2)cn1-c1ccnn1C CHEMBL3910785 IC50 1.0 nM
CCS(=O)(=NC#N)c1ccc(CNC(=O)c2cn(-c3ccnn3C)c(C)c(-c3cccc(C(F)F)c3)c2=O)cc1 CHEMBL3947999 IC50 1.0 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1cnco1 CHEMBL3891848 IC50 1.0 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1-c1ccncc1 CHEMBL3946324 IC50 1.0 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)c1nc2cc(Cl)ccc2o1 CHEMBL128415 Ki 1.1 nM
COC(=O)Cc1ccc2oc(C(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)OCc3ccccc3)C(C)C)C(C)C)nc2c1 CHEMBL335233 Ki 1.1 nM
CCCCOC(=O)NCC(F)(F)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(C)C CHEMBL110685 Ki 1.1 nM
CC(C)c1cc(N2CCN(C)CC2)cc2c1C(=O)N(COC(=O)c1c(Cl)cccc1Cl)S2(=O)=O CHEMBL333152 Ki 1.1 nM
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)CNC(=O)OC(C)(C)C)C(C)C CHEMBL306203 Ki 1.1 nM
COc1ccc(C(=O)N[C@H](C(=O)N2CCCC2C(=O)NC(C(=O)C(F)(F)F)C(C)C)C(C)C)cc1OC CHEMBL56242 Ki 1.1 nM
CCC1(CC)C(=O)N(c2ccc(CSc3nnc(-c4ccccc4)o3)cc2)C1=O CHEMBL567542 Ki 1.1 nM
[C-]#[N+]C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)NC1c1ccc(C#N)cc1S(=O)(=O)CCO CHEMBL3971344 IC50 1.1 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NC1CCC(O)C1 CHEMBL3941471 IC50 1.1 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N(C)CCCOC CHEMBL3945857 IC50 1.1 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NCCS(C)(=O)=O CHEMBL3954557 IC50 1.1 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NC1CCN(C(C)C)C1 CHEMBL3983608 IC50 1.1 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCC(N2CCOCC2)C1 CHEMBL3971729 IC50 1.1 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N[C@@H]1CCNC1 CHEMBL4110747 IC50 1.1 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1-c1cnn(C)c1 CHEMBL3918701 IC50 1.1 nM
CN(C(=O)CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1)C1CC1 CHEMBL3908888 IC50 1.1 nM
CN(C)C(=O)CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1S(C)(=O)=O CHEMBL3922473 IC50 1.1 nM
COCCN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1S(C)(=O)=O CHEMBL3926599 IC50 1.1 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C(=O)NCc2ncco2)cc1 CHEMBL3926400 IC50 1.1 nM
CC(C)OCCNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3926529 IC50 1.1 nM
CNC(=O)N1C(=O)N(c2cccc(C(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3929671 IC50 1.1 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1C(C)C CHEMBL3953410 IC50 1.1 nM
Cc1c(-c2cccc(C(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)c(F)c2)cn1C(C)C CHEMBL3925704 IC50 1.1 nM
CN(Cc1ccon1)C(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3950257 IC50 1.1 nM
CN(C)C(=O)c1cc(C#N)ccc1[C@@H]1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL4115285 IC50 1.1 nM
CN(C)C(=O)c1cc(C#N)ccc1C1C2=C(CCCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3923744 IC50 1.1 nM
CC(C)[C@H](NC(=O)Cn1c(-c2ccc(F)cc2)ncc(N)c1=O)C(=O)c1nnc(C(C)(C)c2ccc3c(c2)OCO3)o1 CHEMBL279941 Ki 1.18 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)C1=N[C@@H](C)CO1 CHEMBL171288 Ki 1.2 nM
CC(C)C(NC(=O)C1CCCN1C(=O)[C@@H](NS(=O)(=O)C12CC3CC(CC(C3)C1)C2)C(C)C)C(=O)C(F)(F)F CHEMBL293558 Ki 1.2 nM
CC(C)C(NC(=O)C1CCCN1C(=O)[C@@H](NC(=O)c1ccc([N+](=O)[O-])cc1)C(C)C)C(=O)C(F)(F)F CHEMBL56907 Ki 1.2 nM
COc1ccc2c(c1OC)C(=O)N(COC(=O)c1c(Cl)cccc1Cl)S2(=O)=O CHEMBL416154 Ki 1.2 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NC1CCN(C(C)C)C1 CHEMBL3951513 IC50 1.2 nM
CN[C@H]1CCN(C(=O)c2cc(C#N)ccc2C2C(C(C)=O)=C(C)N(c3cccc(C(F)(F)F)c3)C(=O)N2C)C1 CHEMBL3952171 IC50 1.2 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NCCCOC CHEMBL3927026 IC50 1.2 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N[C@H]1CCNC1 CHEMBL3951274 IC50 1.2 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C1=CCOCC1 CHEMBL3926710 IC50 1.2 nM
Cn1ccc(CNC(=O)N2C(=O)N(c3cccc(C(F)(F)F)c3)C3=C(C(=O)CC3)C2c2ccc(C#N)cc2)n1 CHEMBL3926096 IC50 1.2 nM
COCCN(C)C(=O)CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1S(C)(=O)=O CHEMBL3946602 IC50 1.2 nM
CCS(=O)(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3940212 IC50 1.2 nM
CCNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1F CHEMBL3893435 IC50 1.2 nM
CNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1Cl CHEMBL3978869 IC50 1.2 nM
CNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1Br CHEMBL3967343 IC50 1.2 nM
CCn1cc(C(=O)NCc2ccc(S(=O)(CC)=NC#N)cc2)c(=O)c(-c2cccc(C(F)(F)F)c2)c1C CHEMBL3927913 IC50 1.2 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(=O)(=NC#N)C(C)C)cc2)cn1C1CC1 CHEMBL3957593 IC50 1.2 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1-c1ccnn1C CHEMBL3936912 IC50 1.2 nM
CNC(=O)N1C(=O)N(c2cncc(Br)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1S(C)(=O)=O CHEMBL3982568 IC50 1.2 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1-c1cnco1 CHEMBL3965188 IC50 1.2 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1-c1ccn(C)c(=O)c1 CHEMBL3937455 IC50 1.2 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CCC2)C1c1ccc(C#N)cc1-c1ccn(C)c(=O)c1 CHEMBL3937771 IC50 1.2 nM
CCC1(CC)C(=O)N(c2ccccc2)C1=O CHEMBL272413 Ki 1.21 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(S(N)(=O)=O)cc1)C(C)C)C(=O)c1nc2ccccc2o1 CHEMBL406200 Ki 1.3 nM
COc1ccc(C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)C(C)C)cc1 CHEMBL55210 Ki 1.3 nM
CC(C)[C@H](NC(=O)Oc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C CHEMBL417935 Ki 1.3 nM
CCC1(CC)C(=O)N(c2ccc(C)nc2)C1=O CHEMBL566919 Ki 1.3 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NCc1ccc(C#N)o1 CHEMBL3942047 IC50 1.3 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NCC(C)(C)O CHEMBL3903607 IC50 1.3 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NC1CCC(O)C1 CHEMBL3972446 IC50 1.3 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCN(C(C)=O)CC1 CHEMBL3922232 IC50 1.3 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NC1CCN(C)C1 CHEMBL3912052 IC50 1.3 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1-c1ccncc1 CHEMBL3945011 IC50 1.3 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)NC1c1ccc(C#N)cc1-c1ccc(=O)n(C)c1 CHEMBL3957975 IC50 1.3 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)NC1c1ccc(C#N)cc1-c1cnco1 CHEMBL3949315 IC50 1.3 nM
CS(=O)(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1CC(=O)O CHEMBL3983925 IC50 1.3 nM
COCCNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1F CHEMBL3958895 IC50 1.3 nM
Cc1c(-c2cccc(C(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1C(C)C CHEMBL3981276 IC50 1.3 nM
CN(Cc1ccn(C)n1)C(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3966381 IC50 1.3 nM
CC(=O)N[C@@H]1CCN(C(=O)c2cc(C#N)ccc2C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C)C1 CHEMBL4109079 IC50 1.3 nM
CN(C)CCN(C)C(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3949810 IC50 1.3 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CCC2)C1c1ccc(C#N)cc1C1=CCOCC1 CHEMBL3913237 IC50 1.3 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1-c1cncnc1 CHEMBL3954616 IC50 1.3 nM
CCOc1nc2sc3c(c2c(=O)o1)CCCC3 CHEMBL49750 Log Ki 1.349 nM
Cc1cccc(C(C)(C)c2nnc(C(=O)[C@@H](NC(=O)Cn3c(-c4ccc(F)cc4)ncc(N)c3=O)C(C)C)o2)c1 CHEMBL278134 Ki 1.37 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NS(=O)(=O)Cc2ccccc2)c1=O)C(=O)C(F)(F)F CHEMBL431864 Ki 1.4 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NCC(C)(C)O CHEMBL3902604 IC50 1.4 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NC(C)c1ccco1 CHEMBL3962704 IC50 1.4 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NC1CCOC1 CHEMBL3912628 IC50 1.4 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NC1CCOCC1 CHEMBL3904811 IC50 1.4 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCNCC1 CHEMBL3909784 IC50 1.4 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1-c1ccn(C)n1 CHEMBL3948797 IC50 1.4 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1-c1cccnc1 CHEMBL3974438 IC50 1.4 nM
CC(C)(O)CNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3915891 IC50 1.4 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C(=O)NCC2(O)CC2)cc1 CHEMBL3909666 IC50 1.4 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(=O)(=NC#N)C3CC3)cc2)cn1C(C)C CHEMBL3965619 IC50 1.4 nM
CCS(=O)(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2ccnc(C(F)(F)F)c2)C(=O)N1C CHEMBL3954241 IC50 1.4 nM
CN(Cc1nncn1C)C(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3900730 IC50 1.4 nM
CNCCN(C)C(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3922795 IC50 1.4 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1CN1CCOCC1 CHEMBL3919316 IC50 1.4 nM
CSc1nc2cccc(C)c2c(=O)o1 CHEMBL143793 pKi 1.413 nM
CCCOc1nc2sc3c(c2c(=O)o1)CCCC3 CHEMBL296620 Ki 1.43 nM
Cc1cccc2nc(NC(C)C)oc(=O)c12 CHEMBL10756 Ki 1.5 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NS(=O)(=O)C(C)C)cc1)C(C)C)C(=O)c1nc2ccccc2o1 CHEMBL130002 Ki 1.5 nM
Cn1cncc1CNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3891647 IC50 1.5 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C(=O)NCC2COCCO2)cc1 CHEMBL3940364 IC50 1.5 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3ccnc(C(F)(F)F)c3)C(=O)N2C(=O)NC2CC2)cc1 CHEMBL3919916 IC50 1.5 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2F)cn1C(C)C CHEMBL3967491 IC50 1.5 nM
CCS(=O)(=NC#N)c1ccc(CNC(=O)c2cn(-c3ccnn3C)c(C)c(-c3cccc(C(F)(F)F)c3)c2=O)cc1 CHEMBL3946427 IC50 1.5 nM
CCn1cc(C(=O)NCc2ccc(S(=O)(CC)=NC#N)cc2)c(=O)c(-c2cccc(C(F)F)c2)c1C CHEMBL3915973 IC50 1.5 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CCC2)C1c1ccc(C#N)cc1C1=COCC1 CHEMBL3950019 IC50 1.5 nM
Cc1cccc2nc(OCC(C)C)oc(=O)c12 CHEMBL145729 pKi 1.585 nM
CC(C)c1cccc2c1C(=O)N(COc1cc(Cl)c(C(=O)OCCN3CCOCC3)c(Cl)c1)S2(=O)=O CHEMBL109411 Ki 1.6 nM
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)CNCc1ccccc1)C(C)C CHEMBL323231 Ki 1.6 nM
CC(C)C(NC(=O)Cn1c(-c2ccc(F)cc2)ncc(NS(=O)(=O)C2CCCCC2)c1=O)C(=O)C(F)(F)F CHEMBL274123 Ki 1.6 nM
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)CNCc1ccccc1)C(C)C CHEMBL68577 Ki 1.6 nM
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C CHEMBL354883 Ki 1.6 nM
CCCCC(=O)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(C)C CHEMBL169887 Ki 1.6 nM
CC(C)C(NC(=O)C1CCCN1C(=O)[C@@H](NS(=O)(=O)c1c(F)c(F)c(F)c(F)c1F)C(C)C)C(=O)C(F)(F)F CHEMBL301691 Ki 1.6 nM
CCN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1S(C)(=O)=O CHEMBL3342779 IC50 1.6 nM
CS(=O)(=O)c1cc(C#N)ccc1C1NC(=O)N(c2cccc(C(F)(F)F)c2)C2=C1C(=O)N(CCNC(N)=O)C2 CHEMBL3974602 IC50 1.6 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NCC(C)(C)C#N CHEMBL3979402 IC50 1.6 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NCC(F)(F)F CHEMBL3890051 IC50 1.6 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)NC1c1ccc(C#N)cc1-c1cn[nH]c1 CHEMBL3967453 IC50 1.6 nM
COc1ccc(-c2cc(C#N)ccc2C2NC(=O)N(c3cccc(C(F)(F)F)c3)C(C)=C2C(C)=O)cn1 CHEMBL3899363 IC50 1.6 nM
CCn1cc(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)c(=O)c(-c2cccc(C(F)(F)F)c2)c1C CHEMBL3951062 IC50 1.6 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1CO CHEMBL3935829 IC50 1.6 nM
CN(CCN1CCOCC1)C(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3909800 IC50 1.6 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CCC2)C1c1ccc(C#N)cc1C(N)=O CHEMBL3916442 IC50 1.6 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CCC2)C1c1ccc(C#N)cc1-c1cn[nH]c1 CHEMBL3976168 IC50 1.6 nM
CC(C)[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)c1cccnc1)C(C)C)C(=O)c1nnc(C(C)(C)C)o1 CHEMBL26571 Ki 1.66 nM
CC(C)[C@H](NC(=O)Oc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)C(=O)NCc1ccccn1)C(C)C CHEMBL110364 Ki 1.7 nM
CC(C)C(NC(=O)C1CCCN1C(=O)[C@H](C(C)C)N(CCCc1ccccc1)CCCc1ccccc1)C(=O)C(F)(F)F CHEMBL542128 Ki 1.7 nM
CC(C)C(NC(=O)C1CCCN1C(=O)[C@@H](NC(=O)c1cc2ccccc2cc1C(=O)O)C(C)C)C(=O)C(F)(F)F CHEMBL55963 Ki 1.7 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1Cc2ccncc2C1 CHEMBL3914045 IC50 1.7 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NC1CCNCC1 CHEMBL3892975 IC50 1.7 nM
Cn1ncc2c1CN(C(=O)CN1C(=O)N(c3cccc(C(F)(F)F)c3)C3=C(C(=O)CC3)C1c1ccc(C#N)cc1)C2 CHEMBL3892781 IC50 1.7 nM
CS(=O)(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1CC1CCOCC1 CHEMBL3984582 IC50 1.7 nM
CCS(=O)(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1S(C)(=O)=O CHEMBL3919083 IC50 1.7 nM
Cn1cnc(CNC(=O)N2C(=O)N(c3cccc(C(F)(F)F)c3)C3=C(C(=O)CC3)C2c2ccc(C#N)cc2)c1 CHEMBL3904603 IC50 1.7 nM
Cc1ccncc1-n1cc(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)c(=O)c(-c2cccc(C(F)(F)F)c2)c1C CHEMBL3923566 IC50 1.7 nM
CN(Cc1ccncc1)C(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3973772 IC50 1.7 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C1=CCN(C(=O)OC(C)(C)C)CC1 CHEMBL3961374 IC50 1.7 nM
CN1C(=O)N(c2ccnc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C1=CCNCC1 CHEMBL3945432 IC50 1.7 nM
CC(C)[C@@H]1C(=O)N(S(C)(=O)=O)[C@@H]2CCN(C(=O)C3CN(CC(C)(C)C)C3)[C@H]21 CHEMBL554013 Ki 1.73 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)c1nc2cc(C#N)ccc2o1 CHEMBL340627 Ki 1.8 nM
O=C1c2ccccc2S(=O)(=O)N1CCl CHEMBL299784 Ki 1.8 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NS(=O)(=O)NCc2ccccc2)c1=O)C(=O)C(F)(F)F CHEMBL282694 Ki 1.8 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)C(N)=O CHEMBL424550 Ki 1.8 nM
CC(C)C(NC(=O)C1CCCN1C(=O)[C@@H](NC(=O)/C=C/c1ccc(C(=O)O)cc1)C(C)C)C(=O)C(F)(F)F CHEMBL418117 Ki 1.8 nM
COC(=O)c1ccc(C(=O)N[C@H](C(=O)N2CCCC2C(=O)NC(C(=O)C(F)(F)F)C(C)C)C(C)C)cc1 CHEMBL56713 Ki 1.8 nM
CCC1(CC)C(=O)N(c2ccc(CSc3ccccc3)cc2)C1=O CHEMBL566934 Ki 1.8 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NC(C)(C)C#N CHEMBL3953861 IC50 1.8 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CC[C@@H](N(C)C)C1 CHEMBL4107663 IC50 1.8 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCN(C(C)C)CC1 CHEMBL3922775 IC50 1.8 nM
CNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1F CHEMBL3917584 IC50 1.8 nM
CCn1cc(C(=O)NCc2ccc(S(=O)(=NC#N)C(C)C)cc2)c(=O)c(-c2cccc(C(F)F)c2)c1C CHEMBL3912480 IC50 1.8 nM
Cc1c(-c2ccc(F)c(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1C(C)C CHEMBL3961184 IC50 1.8 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1C1CCCOC1 CHEMBL3961340 IC50 1.8 nM
CNC(=O)c1cc(C#N)ccc1[C@@H]1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL4114828 IC50 1.8 nM
COc1ccc2oc(C(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)OCc3ccccc3)C(C)C)C(C)C)nc2c1 CHEMBL129496 Ki 1.9 nM
CC(C)[C@H](NC(=O)OC1CCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C CHEMBL2370419 Ki 1.9 nM
[C-]#[N+]C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C(=O)N2CCN(CCO)CC2)[C@@H]1c1ccc(C#N)cc1S(C)(=O)=O CHEMBL4110906 IC50 1.9 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCC(N2CCOCC2)CC1 CHEMBL3946557 IC50 1.9 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1-c1ccco1 CHEMBL3917471 IC50 1.9 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1-c1cn[nH]c1 CHEMBL3927892 IC50 1.9 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C1=COCC1 CHEMBL3933344 IC50 1.9 nM
CN1C(=O)N(c2cccc(C(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1S(C)(=O)=O CHEMBL3973297 IC50 1.9 nM
CS(=O)(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1S(C)(=O)=O CHEMBL3906009 IC50 1.9 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cn2)cn1C(C)C CHEMBL3892713 IC50 1.9 nM
CC[S+]([O-])c1cc(C#N)ccc1[C@@H]1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL4108581 IC50 1.9 nM
CC[S+]([O-])c1cc(C#N)ccc1[C@H]1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3911906 IC50 1.9 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1ccno1 CHEMBL3907388 IC50 1.9 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1cnoc1 CHEMBL3954386 IC50 1.9 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N1CCn2ncnc2C1 CHEMBL3949636 IC50 1.9 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1-c1cncs1 CHEMBL3915978 IC50 1.9 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CCC2)C1c1ccc(C#N)cc1-c1cncs1 CHEMBL3929079 IC50 1.9 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)[C@H]1c1ccc(C#N)cc1CNC(C)(C)C CHEMBL4108155 IC50 1.9 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)[C@H]1c1ccc(C#N)cc1CNC1CCOCC1 CHEMBL4108753 IC50 1.9 nM
Cc1cccc2c1C(=O)N(COC(=O)c1c(Cl)cccc1Cl)S2(=O)=O CHEMBL90327 Log Ki 1.995 nM
O=C(OCN1C(=O)c2ccccc2S1(=O)=O)c1c(Cl)cccc1Cl CHEMBL274085 Log Ki 1.995 nM
CC(C)C(NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(S(=O)(=O)N2CCOCC2)cc1)C(C)C)C(=O)C(F)(F)C(F)(F)F CHEMBL342170 Ki 2.0 nM
CCc1cccc2c1C(=O)N(CSc1nnnn1-c1ccccc1)S2(=O)=O CHEMBL296159 Ki 2.0 nM
COc1ccc2c(c1OC)C(=O)N(CSc1nnnn1-c1ccccc1)S2(=O)=O CHEMBL100620 Ki 2.0 nM
COC(=O)C(=O)[C@@H](NC(=O)C1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccc(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)cc1)C(C)C CHEMBL157261 Ki 2.0 nM
C=CC[C@H]1C(=O)N(C(=O)OCC)[C@H]2CCN(C(=O)OCc3ccccc3)[C@H]12 CHEMBL2367636 IC50 2.0 nM
CO[C@H]1C(=O)N2C(C(=O)C(C)(C)C)=C(C)[C@@H](OC(=O)c3ccc(CSc4nc(=O)c(=O)[nH]n4C)cc3)S(=O)(=O)C12 CHEMBL422261 Ki ss 2.0 nM
CCCN(CC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)C(C)C)C(C)=O CHEMBL2372970 Ki 2.0 nM
CC(C)C(NC(=O)C1CCCN1C(=O)[C@@H](NC(=O)c1ccc(S(C)(=O)=O)cc1)C(C)C)C(=O)C(F)(F)F CHEMBL57368 Ki 2.0 nM
CS(=O)(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)[C@H]1c1ccc(C#N)cc1 CHEMBL4107405 EC50 2.0 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C(=O)NC2(CO)CC2)cc1 CHEMBL3938790 EC50 2.0 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C(=O)NC2CCOCC2)cc1 CHEMBL3935416 EC50 2.0 nM
C[C@H](CO)NC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL4114548 EC50 2.0 nM
CNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)[C@H]1c1ccc(C#N)cc1 CHEMBL4113522 EC50 2.0 nM
N#Cc1ccc([C@@H]2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C(=O)N[C@H]2CCC[C@@H]2O)cc1 CHEMBL3985235 EC50 2.0 nM
CS(=O)(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1CCCO CHEMBL3921937 EC50 2.0 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)[C@@H]1c1ccc(C#N)cc1[S+](C)[O-] CHEMBL3978111 EC50 2.0 nM
CS(=O)(=O)c1cc(C#N)ccc1[C@H]1NC(=O)N(c2cccc(C(F)F)c2)C2=C1C(=O)CC2 CHEMBL4113125 EC50 2.0 nM
CN1C(=O)N(c2cccc(C(F)F)c2)C2=C(C(=O)CC2)[C@H]1c1ccc(C#N)cc1 CHEMBL4106821 EC50 2.0 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCOCC1 CHEMBL3974521 IC50 2.0 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCNC(C)C1 CHEMBL3962821 IC50 2.0 nM
CN(Cc1cnn(C)c1)C(=O)CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1S(C)(=O)=O CHEMBL3934341 IC50 2.0 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1ccon1 CHEMBL3965463 IC50 2.0 nM
CN(CCN)C(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3935605 IC50 2.0 nM
Cc1c(-c2cccc(C(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1-c1ccnn1C CHEMBL3914332 IC50 2.1 nM
CCS(=O)(=NC#N)c1ccc(CNC(=O)c2cn(C3CC3)c(C)c(-c3cccc(C(F)(F)F)c3)c2=O)cc1 CHEMBL3919722 IC50 2.1 nM
N#Cc1ccc(C2NC(=O)N(c3cccc(C(F)(F)F)c3)C3=C2C(=O)CC3)c(S(=O)(=O)CCCO)c1 CHEMBL3950486 IC50 2.1 nM
CC(C)NCc1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3947107 IC50 2.1 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1-c1nnco1 CHEMBL3940546 IC50 2.1 nM
CO[C@H]1C(=O)N2C(C(=O)N3CCC[C@H]3C(=O)O)=C(COC(C)=O)CS(=O)(=O)[C@H]12 CHEMBL446371 Ki 2.2 nM
CC(C)c1cc(N(C)C)cc2c1C(=O)N(COC(=O)c1c(Cl)cccc1Cl)S2(=O)=O CHEMBL323694 Ki 2.2 nM
CCC1(CC)C(=O)N(c2cccnc2)C1=O CHEMBL566906 Ki 2.2 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCC(O)CC1 CHEMBL3918079 IC50 2.2 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2CC(=O)N2CCCC2)cc1 CHEMBL3933291 IC50 2.2 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C(N)=O)cc1 CHEMBL3925766 IC50 2.2 nM
Cc1cc(S(C)(=O)=NC#N)ccc1CNC(=O)c1cn(C(C)C)c(C)c(-c2cccc(C(F)(F)F)c2)c1=O CHEMBL3896267 IC50 2.2 nM
CCS(=O)(=O)c1cc(C#N)ccc1[C@H]1NC(=O)N(c2cccc(C(F)F)c2)C2=C1C(=O)CC2 CHEMBL4107670 IC50 2.2 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N1CCC1 CHEMBL3924962 IC50 2.2 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1ccco1 CHEMBL3898508 IC50 2.2 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1ccn(C)n1 CHEMBL3968285 IC50 2.2 nM
CC(=O)N[C@H]1CCN(C(=O)c2cc(C#N)ccc2C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C)C1 CHEMBL3909102 IC50 2.2 nM
CNCc1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3935112 IC50 2.2 nM
Cc1nnc(-c2cc(C#N)ccc2C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C)o1 CHEMBL3902611 IC50 2.2 nM
CC(C)[C@H](NC(=O)Cn1c(-c2ccc(F)cc2)ncc(N)c1=O)C(=O)c1nnc(Cc2ccccc2)o1 CHEMBL281401 Ki 2.25 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCOCC1 CHEMBL3982463 IC50 2.25 nM
COC(=O)c1ccc(C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)c2nc3ccccc3o2)C(C)C)C(C)C)cc1 CHEMBL338651 Ki 2.3 nM
CC(=O)NCC(F)(F)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)Oc1ccccc1)C(C)C)C(C)C CHEMBL110174 Ki 2.3 nM
CSc1ccc(C(=O)N[C@H](C(=O)N2CCCC2C(=O)NC(C(=O)C(F)(F)F)C(C)C)C(C)C)cc1 CHEMBL55161 Ki 2.3 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)NC1c1ccc(C#N)cc1-c1cnn(C)c1 CHEMBL3973902 IC50 2.3 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1C1CCOCC1 CHEMBL3962558 IC50 2.3 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1C1CCOC1 CHEMBL3895849 IC50 2.3 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N1CCn2cnnc2C1 CHEMBL3893084 IC50 2.3 nM
CC(=O)N(C)[C@H]1CCN(C(=O)c2cc(C#N)ccc2C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C)C1 CHEMBL3895314 IC50 2.3 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)c1nc2cc(CO)ccc2o1 CHEMBL131107 Ki 2.4 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3342777 IC50 2.4 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1C[C@H]2C[C@@H]1CN2 CHEMBL4109843 IC50 2.4 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1-c1ccn(C)n1 CHEMBL3942196 IC50 2.4 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)[C@H]1c1ccc(C#N)cc1 CHEMBL4112320 IC50 2.4 nM
CC(C)NC(=O)N1C(=O)N(c2ccnc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3959572 IC50 2.4 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1C1CCC1 CHEMBL3942334 IC50 2.4 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)c(F)c2)cn1C(C)C CHEMBL3942652 IC50 2.4 nM
Cc1cc(S(C)(=O)=NC#N)ccc1CNC(=O)c1cn(C(C)C)c(C)c(-c2cccc(C(F)F)c2)c1=O CHEMBL3932511 IC50 2.4 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1nccn1C CHEMBL3979300 IC50 2.4 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)[C@H]1c1ccc(C#N)cc1C(N)=O CHEMBL4114050 IC50 2.4 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CCC2)C1c1ccc(C#N)cc1-c1cnn(C)c1 CHEMBL3970418 IC50 2.4 nM
Cn1cc(-c2cc(C#N)ccc2C2NC(=O)N(c3cccc(C(F)(F)F)c3)C3=C2C(=O)CC3)ccc1=O CHEMBL3978145 IC50 2.4 nM
N#Cc1ccc(C2NC(=O)N(c3cccc(C(F)(F)F)c3)C3=C2C(=O)CC3)c(-c2cnco2)c1 CHEMBL3892116 IC50 2.4 nM
CC(C)C(NC(=O)C1CCCN1C(=O)[C@@H](NC(=O)c1ccc(N(C)C)cc1)C(C)C)C(=O)C(F)(F)F CHEMBL56342 Ki 2.5 nM
CCn1cc(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)c(=O)c(-c2cccc(C(F)F)c2)c1C CHEMBL3939960 IC50 2.5 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1-c1ccncc1 CHEMBL3973290 IC50 2.5 nM
Cc1c(-c2cccc(C(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2F)cn1C(C)C CHEMBL3897617 IC50 2.5 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N1CC(O)C1 CHEMBL3969040 IC50 2.5 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1nnnn1C CHEMBL3955896 IC50 2.5 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C1=CCN(C(=O)OC(C)(C)C)C1 CHEMBL3952678 IC50 2.5 nM
CC(C)[C@H](NC(=O)Cn1c(-c2ccccc2)ncc(N)c1=O)C(=O)c1nnc(C(C)(C)c2ccccc2)o1 CHEMBL281894 Ki 2.55 nM
CC(C)[C@H](NC(=O)Nc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C CHEMBL2372969 Ki 2.6 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1-c1ccoc1 CHEMBL3940028 IC50 2.6 nM
CCCOC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3982911 IC50 2.6 nM
CS(=O)(=O)CCOC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3931400 IC50 2.6 nM
Cc1noc(C)c1-n1cc(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)c(=O)c(-c2cccc(C(F)(F)F)c2)c1C CHEMBL3986298 IC50 2.6 nM
CC(=O)N(C)[C@@H]1CCN(C(=O)c2cc(C#N)ccc2C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C)C1 CHEMBL4114290 IC50 2.6 nM
CC(C)COC(=O)N(C)c1nc2ccccc2c(=O)o1 CHEMBL145035 pKi 2.692 nM
CC(C)C(NC(=O)C1CCCN1C(=O)[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)C(C)C)C(=O)C(F)(F)F CHEMBL55726 Ki 2.7 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCN(C(C)C)CC1 CHEMBL3902475 IC50 2.7 nM
CC1(O)CCN(C(=O)CN2C(=O)N(c3cccc(C(F)(F)F)c3)C3=C(C(=O)CC3)C2c2ccc(C#N)cc2)C1 CHEMBL3952994 IC50 2.7 nM
CS(=O)(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1CC(F)F CHEMBL3920287 IC50 2.7 nM
CCS(=O)(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3895527 IC50 2.7 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)c[n+]2[O-])cn1C(C)C CHEMBL3898512 IC50 2.7 nM
CCSc1nc2sc(C)c(C)c2c(=O)o1 CHEMBL48654 Ki 2.73 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)cc2c(=O)n(CC(=O)OCc3ccccc3)c(=O)[nH]c2c1=O)C(=O)C(F)(F)F CHEMBL13753 Ki 2.8 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCc2nocc2C1 CHEMBL3924776 IC50 2.8 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CC[C@@H](N(C)C)C1 CHEMBL4107254 IC50 2.8 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCN2CCCC2C1 CHEMBL3917331 IC50 2.8 nM
Cc1noc(-c2cc(C#N)ccc2C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C)n1 CHEMBL3975223 IC50 2.8 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CCC2)C1c1ccc(C#N)cc1-c1ccn(C)n1 CHEMBL3952192 IC50 2.8 nM
CC(C)[C@H](NC(=O)c1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C CHEMBL2372976 Ki 2.9 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCN(C2CC2)CC1 CHEMBL3978786 IC50 2.9 nM
CC(=O)N1CCN(C(=O)CN2C(=O)N(c3cccc(C(F)(F)F)c3)C3=C(C(=O)CC3)C2c2ccc(C#N)cc2)CC1 CHEMBL3977042 IC50 2.9 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2CC(=O)N2CCc3[nH]c(=O)ccc3C2)cc1 CHEMBL3963475 IC50 2.9 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C(=O)N[C@@H]2CCC[C@@H]2O)cc1 CHEMBL4114938 IC50 2.9 nM
CN(CCO)C(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3897990 IC50 2.9 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1cccnn1 CHEMBL3906091 IC50 2.9 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)[C@H]1c1ccc(C#N)cc1C(=O)N1CCOCC1 CHEMBL4115034 IC50 2.9 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CCC2)C1c1ccc(C#N)cc1C(=O)N1CCOCC1 CHEMBL3986204 IC50 2.9 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1CNC1CCOCC1 CHEMBL3955837 IC50 2.9 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)c1nc2ccccc2o1 CHEMBL108783 Ki 3.0 nM
CCOc1cccc2c1C(=O)N(CSc1nnnn1-c1ccccc1)S2(=O)=O CHEMBL299730 Ki 3.0 nM
CNC(=O)C(F)(F)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(C)C CHEMBL308415 Ki 3.0 nM
CCC[C@H]1C(=O)N(S(C)(=O)=O)[C@H]2CCN(C(=O)CCN3CCCCC3)[C@H]12 CHEMBL2368634 IC50 3.0 nM
CC(=O)O/C(=C(/NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)cc1)C(C)C)C(C)C)C(F)(F)F CHEMBL75526 Ki 3.0 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)c2nc3cncnc3n2C1c1ccc(C#N)cc1 CHEMBL3659903 IC50 3.0 nM
CN1CC2=C(C(=O)N1)C(c1ccc(C#N)cc1S(C)(=O)=O)NC(=O)N2c1cccc(C(F)(F)F)c1 CHEMBL3642657 IC50 3.0 nM
CC(C)(O)CNC(=O)N1C(=O)N(c2ccnc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3901683 EC50 3.0 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCN(CC)CC1 CHEMBL3964905 IC50 3.0 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(N)=O CHEMBL3979620 IC50 3.0 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NC CHEMBL3930979 IC50 3.0 nM
CCNC(=O)c1cc(C#N)ccc1C1C(C(=O)OCC)=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3914071 IC50 3.0 nM
C#CCNC(=O)c1cc(C#N)ccc1C1C(C(=O)OCC)=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3935672 IC50 3.0 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NCC#N CHEMBL3896678 IC50 3.0 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NC1CC1 CHEMBL3956044 IC50 3.0 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCC1 CHEMBL3984659 IC50 3.0 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)NCCO CHEMBL3940323 IC50 3.0 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1-c1ccc2c(cnn2C)c1 CHEMBL3950280 IC50 3.0 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C1=CCN(C(=O)OC(C)(C)C)CC1 CHEMBL3892039 IC50 3.0 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C1=CCNCC1 CHEMBL3920059 IC50 3.0 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2CC(=O)N2CCSCC2)cc1 CHEMBL3985135 IC50 3.0 nM
Cc1c(-c2cccc(C(F)F)c2)c(=O)c(C(=O)NCc2ccc3c(c2)CCS3(=O)=O)cn1C(C)C CHEMBL3965461 IC50 3.0 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N1CCC(N2CCOCC2)C1 CHEMBL3922247 IC50 3.0 nM
COc1ccc(C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)C(F)(F)C(=O)NCc2ccccn2)C(C)C)C(C)C)cc1 CHEMBL108873 Ki 3.1 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1-c1ccnn1C CHEMBL3914202 IC50 3.1 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1-c1nccs1 CHEMBL3895569 IC50 3.1 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCC#N CHEMBL3961491 IC50 3.1 nM
CN1CCN(C(=O)c2cc(C#N)ccc2[C@@H]2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C)CC1 CHEMBL4110826 IC50 3.1 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCCN CHEMBL3948817 IC50 3.1 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1-c1cccnc1 CHEMBL3904611 IC50 3.1 nM
CC(C)c1cc(C(C)C)c(S(=O)(=O)N[C@H](C(=O)N2CCCC2C(=O)NC(C(=O)C(F)(F)F)C(C)C)C(C)C)c(C(C)C)c1 CHEMBL55386 Ki 3.2 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1-c1ccoc1 CHEMBL3926241 IC50 3.2 nM
COC(=O)CCCS(=O)(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3926343 IC50 3.2 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CCC2)C1c1ccc(C#N)cc1-c1ccoc1 CHEMBL3891876 IC50 3.2 nM
CCC1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CO)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2 CHEMBL4557877 Ki 3.2 nM
CC(C)C(NC(=O)C1CCCN1C(=O)[C@@H](NS(=O)(=O)c1ccc(Cl)cc1)C(C)C)C(=O)C(F)(F)F CHEMBL54522 Ki 3.3 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2CC(=O)N2CCNC(=O)C2)cc1 CHEMBL3959423 IC50 3.3 nM
CCNC(=O)N1C(=O)N(c2ccnc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3947661 IC50 3.3 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1-c1cccnc1 CHEMBL3944990 IC50 3.3 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1-c1cncnc1 CHEMBL3937704 IC50 3.3 nM
COCCCN(C)C(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3913671 IC50 3.3 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N1CC[C@H](N)C1 CHEMBL3907288 IC50 3.3 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1CNC(C)(C)C CHEMBL3947941 IC50 3.3 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1-c1ccoc1 CHEMBL3938536 IC50 3.3 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1-c1ccco1 CHEMBL3975639 IC50 3.3 nM
CC(C)[C@H](NC(=O)Cn1c(-c2ccc(F)cc2)nccc1=O)C(=O)c1nnc(C(C)(C)c2ccccc2)o1 CHEMBL279704 Ki 3.35 nM
CCCCOC(=O)NCC(F)(F)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(OC)cc1)C(C)C)C(C)C CHEMBL110400 Ki 3.4 nM
CNC(=O)C(F)(F)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(OC)cc1)C(C)C)C(C)C CHEMBL306877 Ki 3.4 nM
COc1ccc(C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)C(F)(F)CNC(=O)OC(C)(C)C)C(C)C)C(C)C)cc1 CHEMBL302123 Ki 3.4 nM
COC1CCN(C(=O)CN2C(=O)N(c3cccc(C(F)(F)F)c3)C3=C(C(=O)CC3)C2c2ccc(C#N)cc2)C1 CHEMBL3954303 IC50 3.4 nM
COC1CCN(C(=O)CN2C(=O)N(c3cccc(C(F)(F)F)c3)C3=C(C(=O)CC3)C2c2ccc(C#N)cc2)CC1 CHEMBL3977805 IC50 3.4 nM
CS(=O)(=O)c1cc(C#N)ccc1[C@@H]1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1CC#N CHEMBL3617974 IC50 3.4 nM
Cc1cc(CNC(=O)c2cn(C(C)C)c(C)c(-c3cccc(C(F)(F)F)c3)c2=O)ccc1S(C)(=O)=NC#N CHEMBL3895931 IC50 3.4 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N1CCCC1 CHEMBL3951709 IC50 3.4 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1ccoc1 CHEMBL3901935 IC50 3.4 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1cocn1 CHEMBL3901406 IC50 3.4 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NC(C)(C)C#N CHEMBL3900909 IC50 3.4 nM
CC(C)C(NC(=O)Cn1c(-c2cccc(Cl)c2)ccc(NC(=O)OCc2ccccc2)c1=O)C(=O)C(F)(F)F CHEMBL325234 Ki 3.5 nM
CC(C)c1cccc2c1C(=O)N(COc1ccc(Cl)c(C(=O)NCCN3CCOCC3)c1Cl)S2(=O)=O CHEMBL109488 Ki 3.5 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)COc1ccc(SCC(C)(C)C(=O)O)cc1)C(C)C)C(=O)c1nc2ccccc2o1 CHEMBL152817 IC50 3.5 nM
CC(C)CC(=O)NCC(F)(F)C(=O)C(CC1CCCCC1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(C)C CHEMBL67695 IC50 3.5 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(CC(=O)O)[C@@H]1c1ccc(C#N)cc1 CHEMBL3617969 IC50 3.5 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2CC(=O)N2CC3CC3C2)cc1 CHEMBL3923264 IC50 3.5 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NC1CC[C@H](N(C)C)C1 CHEMBL3895739 IC50 3.5 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CCC2)C1c1ccc(C#N)cc1C(=O)N1CCNCC1 CHEMBL3907593 IC50 3.5 nM
CC(C)(C)C(=O)Oc1ccc(S(=O)(=O)Nc2ccccc2C(=O)NCC(=O)O)cc1 CHEMBL76688 IC50 3.5 nM
CC(C)[C@H](NC(=O)Cn1c(-c2ccccc2)ncc(N)c1=O)C(=O)c1nnc(C(C)(C)C)o1 CHEMBL23234 Ki 3.59 nM
CC(C)C(NC(=O)Cn1c(-c2ccc(N)cc2)ncc(NC(=O)OCc2ccccc2)c1=O)C(=O)C(F)(F)F CHEMBL11398 Ki 3.6 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2CC(=O)N2CCC(F)C2)cc1 CHEMBL3910290 IC50 3.6 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2CC(=O)N2CCC2)cc1 CHEMBL3342778 IC50 3.7 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1-c1ccco1 CHEMBL3950428 IC50 3.7 nM
Cc1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1S(C)(=O)=O CHEMBL3955022 IC50 3.7 nM
Cc1c(-c2cccc(C(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1-c1ccccc1 CHEMBL3947453 IC50 3.7 nM
Cc1c(-c2cccc(C(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1-c1cccnc1 CHEMBL3972292 IC50 3.7 nM
C#CCNC(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3984844 IC50 3.7 nM
COc1cc(OC)cc(-c2ccc(NC(=O)OCc3ccccc3)c(=O)n2CC(=O)NC(C(=O)C(F)(F)F)C(C)C)c1 CHEMBL112880 Ki 3.8 nM
CC(C)[C@H](NC(=O)c1ccncc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C CHEMBL2372982 Ki 3.8 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCN2CCOCC2C1 CHEMBL3894795 IC50 3.8 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2CC(=O)N2CCCCC2)cc1 CHEMBL3983194 IC50 3.8 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2CC(=O)N2CCOCC2)cc1 CHEMBL3974823 IC50 3.8 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1ncco1 CHEMBL3916368 IC50 3.8 nM
CN[C@H]1CCN(C(=O)c2cc(C#N)ccc2C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C)C1 CHEMBL3951601 IC50 3.8 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1-c1ccncn1 CHEMBL3962218 IC50 3.8 nM
CC(C)[C@H](NC(=O)c1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C CHEMBL2372966 Ki 3.9 nM
CCC1(CC(C)C)C(=O)N(c2ccccc2)C1=O CHEMBL566475 Ki 3.9 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2CC(=O)N2CCC(O)C2)cc1 CHEMBL3959177 IC50 3.9 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2CC(=O)N2CC[S+]([O-])CC2)cc1 CHEMBL3961790 IC50 3.9 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1cccnc1 CHEMBL3892456 IC50 3.9 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N1Cc2ccncc2C1 CHEMBL3928282 IC50 3.9 nM
COc1ccc(-c2cc(C#N)ccc2C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C)cn1 CHEMBL3927141 IC50 3.9 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)O CHEMBL3957274 IC50 3.93 nM
CCCOc1nc2sc(C)c(C)c2c(=O)o1 CHEMBL299381 Log Ki 3.981 nM
Cc1cccc(C)c1C(=O)OCN1C(=O)c2ccccc2S1(=O)=O CHEMBL89549 Ki 4.0 nM
CC(C)C(NC(=O)[C@@H]1CCCN1C(=O)[C@H](NC(=O)c1ccc(C(=O)NS(=O)(=O)c2ccc(Br)cc2)cc1)C(C)C)C(=O)C(F)(F)F CHEMBL116606 Ki 4.0 nM
CC(C)c1cccc2c1C(=O)N(COc1ccc(Cl)c(C(=O)N3CCN(C)CC3)c1Cl)S2(=O)=O CHEMBL322104 Ki 4.0 nM
CC(C)C(NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NC(Cc2ccccc2)C(=O)C(F)(F)F)cc1)C(C)C)C(=O)C(F)(F)C(F)(F)F CHEMBL150384 Ki 4.0 nM
CC(=O)OCC1=C(C(=O)C(C)(C)C)N2C(=O)[C@H](Cl)C2S(=O)(=O)C1 CHEMBL131055 Ki ss 4.0 nM
CO[C@H]1C(=O)N2C(C(=O)C(C)(C)C)=C(C)[C@@H](OC(C)=O)S(=O)(=O)C12 CHEMBL129195 Ki ss 4.0 nM
CN1CC2=C(C(=O)N1)[C@@H](c1ccc(C#N)cc1)N(CC(=O)N(C)C)C(=O)N2c1cccc(C(F)(F)F)c1 CHEMBL3642662 IC50 4.0 nM
CN(C)C(=O)CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3980137 EC50 4.0 nM
CNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)[C@H]1c1ccc(C#N)cc1F CHEMBL4112495 EC50 4.0 nM
COC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3907698 IC50 4.0 nM
CNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cn1 CHEMBL3970037 IC50 4.0 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc3c(c2)CCS3(=O)=O)cn1C(C)C CHEMBL3956637 IC50 4.0 nM
Cc1c(-c2cccc(C(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1-c1ccncc1 CHEMBL3959491 IC50 4.0 nM
CC(C)[C@H](NC(=O)Oc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)CNCc1ccccc1)C(C)C CHEMBL108504 Ki 4.1 nM
Cc1cc(COC(=O)Nc2ccc(-c3ccccc3)n(CC(=O)NC(C(=O)C(F)(F)F)C(C)C)c2=O)cc(C)n1 CHEMBL113187 Ki 4.1 nM
CC(C)[C@H](NC(=O)Oc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)CNCc1ccccc1)C(C)C CHEMBL305259 Ki 4.1 nM
CCN1CCN(C(=O)c2cc(C#N)ccc2C2C(C(C)=O)=C(C)N(c3cccc(C(F)(F)F)c3)C(=O)N2C)CC1 CHEMBL3967157 IC50 4.1 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1ccncc1 CHEMBL3973572 IC50 4.1 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N1Cc2cnn(C)c2C1 CHEMBL3962810 IC50 4.1 nM
CCCCNc1nc2cccc(CC)c2c(=O)o1 CHEMBL143431 pKi 4.169 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)c1nc2cc(C(=O)O)ccc2o1 CHEMBL1237168 Ki 4.2 nM
CC(C)C(NC(=O)C1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NS(C)(=O)=O)cc1)C(C)C)C(=O)C(F)(F)F CHEMBL293707 Ki 4.2 nM
CCOC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3889979 IC50 4.2 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1ccccn1 CHEMBL3961446 IC50 4.2 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1cncn1C CHEMBL3893672 IC50 4.2 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1-c1ccccn1 CHEMBL3889894 IC50 4.3 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NC1CCS(=O)(=O)C1 CHEMBL3947175 IC50 4.3 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)c1nc2cc(CC(=O)O)ccc2o1 CHEMBL435413 Ki 4.4 nM
CC(C)C(NC(=O)Cn1c(-c2cccc(OC(C)(C)C)c2)ccc(NC(=O)OCc2ccccc2)c1=O)C(=O)C(F)(F)F CHEMBL113132 Ki 4.4 nM
CCOP(=O)(OCC)OCN1C(=O)c2c(C(C)C)cc(O)cc2S1(=O)=O CHEMBL39165 Ki 4.5 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NC(=O)OCc2ccccc2)c1=O)C(=O)C(F)(F)F CHEMBL11391 Ki 4.5 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCNC(C)C1 CHEMBL3980996 IC50 4.5 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCCN1CCOCC1 CHEMBL3923288 IC50 4.5 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NS(C)(=O)=O)cc1)C(C)C)C(=O)c1nc2ccccc2o1 CHEMBL336132 Ki 4.6 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)NC1c1ccc(C#N)cc1-c1ccoc1 CHEMBL3937829 IC50 4.6 nM
CSc1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3892133 IC50 4.6 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCCS(C)(=O)=O CHEMBL3941882 IC50 4.6 nM
CC(=O)N1CCN(C(=O)c2cc(C#N)ccc2C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C)CC1 CHEMBL3985969 IC50 4.6 nM
CN1C(=O)N(c2ccnc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C1=CCN(C(=O)OC(C)(C)C)CC1 CHEMBL3928751 IC50 4.6 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCC(O)CC1 CHEMBL3917044 IC50 4.7 nM
CCS(=O)(=O)c1cc(C#N)ccc1C1NC(=O)N(c2cccc(C(F)(F)F)c2)C2=C1C(=O)CC2 CHEMBL3955112 IC50 4.7 nM
Cc1c(-c2ccnc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1C(C)C CHEMBL3925786 IC50 4.7 nM
Cc1c(-c2ccc(F)c(C(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1C(C)C CHEMBL3970018 IC50 4.7 nM
Cc1ccc(-n2cc(C(=O)NCc3ccc(S(C)(=O)=NC#N)cc3)c(=O)c(-c3cccc(C(F)(F)F)c3)c2C)cn1 CHEMBL3908065 IC50 4.7 nM
CNCCNC(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3917492 IC50 4.7 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NC(=O)OCc2cccc(C(=O)O)c2)c1=O)C(=O)C(F)(F)F CHEMBL333835 Ki 4.8 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCC(N)CC1 CHEMBL3924499 IC50 4.8 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C1=CCN(C(=O)OC(C)(C)C)CC1 CHEMBL3958982 IC50 4.8 nM
CN(C)CCNC(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3984532 IC50 4.8 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1cnn(C)c1 CHEMBL3936041 IC50 4.8 nM
Cn1cc(-c2cc(C#N)ccc2C2NC(=O)N(c3cccc(C(F)(F)F)c3)C3=C2C(=O)CC3)cn1 CHEMBL3963617 IC50 4.8 nM
CCOc1nc2cc(N(C)C)ccc2c(=O)o1 CHEMBL342522 pKi 4.898 nM
CC(C)C(NC(=O)Cn1c(-c2cccs2)ncc(N)c1=O)B1OC(C)(C)C(C)(C)O1 CHEMBL11113 Ki 4.9 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)cc2c3cccc(C=O)c3nc-2c1O)C(=O)C(F)(F)F CHEMBL424770 Ki 4.9 nM
CNC(=O)N1C(=O)N(c2ccnc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3985012 IC50 4.9 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N[C@H]1C[C@H]1N CHEMBL4114064 IC50 4.9 nM
O=C(OCN1C(=O)C2=C(CCC2)S1(=O)=O)c1c(Cl)cccc1Cl CHEMBL112514 Ki 5.0 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C(=O)N[C@@H]2CCC[C@H]2O)cc1 CHEMBL4111631 EC50 5.0 nM
CCC(CC)n1cc(C(=O)NCc2ccc(S(C)(=O)=O)cn2)c(=O)c(-c2cccc(C(F)F)c2)c1C CHEMBL3894701 IC50 5.0 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCCCO CHEMBL3915713 IC50 5.0 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1cn[nH]c1 CHEMBL3977940 IC50 5.0 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1ccnnc1 CHEMBL3981645 IC50 5.0 nM
CC(C)[C@H](NC(=O)[C@@H]1Cc2ccccc2N1C(=O)[C@@H](NC(=O)c1cccnc1)C(C)C)C(=O)c1nnc(C(C)(C)C)o1 CHEMBL23104 Ki 5.1 nM
CS(=O)(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3928409 IC50 5.1 nM
CN1CCN(C(=O)c2cc(C#N)ccc2C2C3=C(CCCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C)CC1 CHEMBL3911026 IC50 5.1 nM
COc1cc2c(c(C(C)C)c1OC)C(=O)N(CSc1nnnn1-c1ccccc1)S2(=O)=O CHEMBL112205 Ki 5.2 nM
CC(C)C(NC(=O)C1CCCN1C(=O)[C@@H](NS(=O)(=O)c1ccc([N+](=O)[O-])cc1)C(C)C)C(=O)C(F)(F)F CHEMBL59258 Ki 5.2 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(=O)(=O)C3CC3)cc2)cn1C(C)C CHEMBL3926922 IC50 5.2 nM
CC[S+]([O-])c1cc(C#N)ccc1[C@H]1NC(=O)N(c2cccc(C(F)(F)F)c2)C2=C1C(=O)CC2 CHEMBL4111006 IC50 5.2 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C1=CN(C(=O)OC(C)(C)C)CC1 CHEMBL3889943 IC50 5.3 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2cn3c(n2)S(=O)(=O)CC3)cn1C(C)C CHEMBL3967350 IC50 5.3 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(N)=O CHEMBL3932398 IC50 5.3 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NC1COC1 CHEMBL3939530 IC50 5.3 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1ccccc1 CHEMBL3975702 IC50 5.3 nM
CC(C)C(NC(=O)C1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NCCN(C)C)cc1)C(C)C)C(=O)C(F)(F)F CHEMBL292141 Ki 5.4 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CC2CC1CN2 CHEMBL3941173 IC50 5.4 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc([S+](C)[O-])cc2)cn1C(C)C CHEMBL3921631 IC50 5.4 nM
CN(C)C(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3907851 IC50 5.4 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1ccnn1C CHEMBL3974416 IC50 5.4 nM
CCCC1C(=O)N(COC(=O)c2c(Cl)cccc2Cl)S(=O)(=O)N1C CHEMBL260190 Ki 5.47 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1-c1ccccc1 CHEMBL3917901 IC50 5.5 nM
CCS(=O)(=O)c1cc(C#N)ccc1C1NC(=O)N(c2cccc(C(F)F)c2)C2=C1C(=O)CC2 CHEMBL3946789 IC50 5.5 nM
CCNC(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3965799 IC50 5.5 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCCF CHEMBL3977540 IC50 5.5 nM
CC(C)C(NC(=O)Cn1c(-c2cccc(O)c2)ccc(NC(=O)OCc2ccccc2)c1=O)C(=O)C(F)(F)F CHEMBL113321 Ki 5.6 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NC#N)cc2)cn1C1CC1 CHEMBL3895233 IC50 5.6 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NC1CC[C@@H](N(C)C)C1 CHEMBL4110043 IC50 5.6 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N[C@H]1C[C@@H]1N CHEMBL3978808 IC50 5.6 nM
CCOc1nc2scc(C(C)C)c2c(=O)o1 CHEMBL298959 Ki 5.61 nM
CCSc1nc2sc3c(c2c(=O)o1)CCCC3 CHEMBL297154 Ki 5.7 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NC(=O)OCc2ccc(C(=O)O)cc2)c1=O)C(=O)C(F)(F)F CHEMBL280916 Ki 5.7 nM
COc1ccc(Cn2c(=O)[nH]c3c(=O)n(CC(=O)NC(C(=O)C(F)(F)F)C(C)C)c(-c4ccccc4)cc3c2=O)cc1 CHEMBL14121 Ki 5.7 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1-c1ccc2c(ccn2C)c1 CHEMBL3968829 IC50 5.7 nM
COCCS(=O)(=O)c1cc(C#N)ccc1C1NC(=O)N(c2cccc(C(F)(F)F)c2)C2=C1C(=O)CC2 CHEMBL3959247 IC50 5.7 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCCO CHEMBL3896916 IC50 5.7 nM
COCCCNC(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3961074 IC50 5.7 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CCC2)C1c1ccc(C#N)cc1-c1ccco1 CHEMBL3982126 IC50 5.7 nM
CSc1nc2sc3c(c2c(=O)o1)CCCC3 CHEMBL301736 Ki 5.74 nM
CCOc1nc2cc(N)ccc2c(=O)o1 CHEMBL141707 pKi 5.754 nM
CC(=O)N(C)c1nc2ccccc2c(=O)o1 CHEMBL141553 pKi 5.754 nM
CCN(CC)c1nc2sc3ccccc3c2c(=O)o1 CHEMBL153687 Log Ki 5.754 nM
CC(C)OC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)C(C)C CHEMBL321817 Ki 5.8 nM
CS(=O)(=O)c1cc(C#N)ccc1C1NC(=O)N(c2cccc(C(F)(F)F)c2)C2=C1C(=O)CC2 CHEMBL3950032 IC50 5.8 nM
N#Cc1ccc(C2NC(=O)N(c3cccc(C(F)(F)F)c3)C3=C2C(=O)CC3)c(-c2cn[nH]c2)c1 CHEMBL3921323 IC50 5.8 nM
Cc1cc(C)c2c(=O)oc(NC(C)C)nc2c1 CHEMBL146004 pKi 5.888 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N1CC[C@@H](N)C1 CHEMBL4111178 IC50 5.9 nM
Cn1ccc(-c2cc(C#N)ccc2C2NC(=O)N(c3cccc(C(F)(F)F)c3)C3=C2C(=O)CC3)cc1=O CHEMBL3907616 IC50 5.9 nM
CCCNc1nc2cccc(C)c2c(=O)o1 CHEMBL343250 Ki 6.0 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NS(=O)(=O)c2ccccc2)c1=O)C(=O)C(F)(F)F CHEMBL304354 Ki 6.0 nM
CO[C@H]1C(=O)N2C(C(=O)C(C)(C)C)=C(COC(C)=O)[C@@H](Sc3nnnn3C)S(=O)(=O)C12 CHEMBL337518 Ki ss 6.0 nM
O=C(c1ccc(F)cc1)n1cc(Cl)cn1 CHEMBL243437 Ki 6.0 nM
CC(C)(O)CCNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3898626 EC50 6.0 nM
CC1CCN(C(=O)CN2C(=O)N(c3cccc(C(F)(F)F)c3)C3=C(C(=O)CC3)C2c2ccc(C#N)cc2)CC1 CHEMBL3959206 IC50 6.0 nM
CN1CCN(C(=O)CN2C(=O)N(c3cccc(C(F)(F)F)c3)C3=C(C(=O)CC3)C2c2ccc(C#N)cc2)CC1=O CHEMBL3979785 IC50 6.0 nM
Cc1cc(CNC(=O)c2cn(C(C)C)c(C)c(-c3cccc(C(F)F)c3)c2=O)ccc1S(C)(=O)=O CHEMBL3931629 IC50 6.0 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCC(F)F CHEMBL3947054 IC50 6.0 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1nncn1C CHEMBL3962456 IC50 6.0 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCC(=O)N1CCOCC1 CHEMBL3937742 IC50 6.0 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1-c1ccc2c(ccn2C)c1 CHEMBL3926122 IC50 6.0 nM
Cc1cccc(C(=O)n2cc3c(n2)CCC(Br)C3=O)c1 CHEMBL5088711 Ki 6.0 nM
Cc1cccc(C(=O)n2cc3c(n2)CCC(Br)(Br)C3=O)c1 CHEMBL5078775 Ki 6.0 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)cc2c3ccccc3nc-2c1O)C(=O)C(F)(F)F CHEMBL325154 Ki 6.1 nM
CC(C)C(NC(=O)C1CCCN1C(=O)[C@@H](NC(=O)CCC(=O)NS(=O)(=O)c1cccc2ccccc12)C(C)C)C(=O)C(F)(F)F CHEMBL291309 Ki 6.1 nM
CC(C)C(NC(=O)Cn1c(-c2ccc(F)cc2)ncc(N)c1=O)B1OC(C)(C)C(C)(C)O1 CHEMBL269181 Ki 6.2 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCC(C)(C)N CHEMBL3983625 IC50 6.2 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NS(=O)(=O)c1cccc2c(N(C)C)cccc12)C(=O)C(F)(F)F CHEMBL339870 Ki 6.3 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCN2CCCC2C1 CHEMBL3957785 IC50 6.3 nM
CN1CCN(C(=O)CN2C(=O)N(c3cccc(C(F)(F)F)c3)C3=C(C(=O)CC3)C2c2ccc(C#N)cc2)CC1 CHEMBL3944244 IC50 6.3 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NC1CC1 CHEMBL3902427 IC50 6.3 nM
CC(C)[C@H](NC(=O)Cn1c(-c2ccc(F)cc2)ncc(N)c1=O)C(=O)c1nnc(C(C)(C)C)o1 CHEMBL282705 Ki 6.38 nM
COc1ccc(C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)C(F)(F)CNC(=O)c2ccccc2)C(C)C)C(C)C)cc1 CHEMBL109949 Ki 6.4 nM
COC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)c1nn(-c2ccc(N(C)C)cc2)c(=O)o1)C(C)C)C(C)C CHEMBL270651 Ki 6.4 nM
Cc1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3911289 IC50 6.4 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N[C@@H]1CCNC1 CHEMBL4111193 IC50 6.4 nM
CCOc1nc2ccccc2c(=O)o1 CHEMBL450273 pKi 6.457 nM
O=C1c2ccccc2S(=O)(=O)N1COP(=O)(Oc1ccccc1)Oc1ccccc1 CHEMBL288700 Ki 6.5 nM
CCOC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)c2nccn2[C@@H]1c1ccc(C#N)cc1 CHEMBL3659904 IC50 6.5 nM
CN(CC1CCOC1)C(=O)CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3907339 IC50 6.5 nM
COCCNC(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3965922 IC50 6.5 nM
CC(C)C(NC(=O)Cn1c(-c2ccc(Cl)cc2)ccc(NC(=O)OCc2ccccc2)c1=O)C(=O)C(F)(F)F CHEMBL113261 Ki 6.6 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)ncc(NC(=O)OCc2ccccc2)c1=O)C(=O)C(F)(F)F CHEMBL11403 Ki 6.6 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)cc2c3cccc(C#N)c3nc-2c1O)C(=O)C(F)(F)F CHEMBL176540 Ki 6.6 nM
COC(=O)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)Cn1ccc(=O)n(CC(=O)O)c1=O)C(C)C)C(C)C CHEMBL596517 IC50 6.6 nM
COC(=O)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)CN1CCN(CC(=O)O)C(=O)C1=O)C(C)C)C(C)C CHEMBL595377 IC50 6.6 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N(C)C1C2CC1C2 CHEMBL3910335 IC50 6.6 nM
CC(NC(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C)c1ccco1 CHEMBL3903053 IC50 6.6 nM
Cc1ccc(C)c2c(=O)oc(NC(C)C)nc12 CHEMBL146003 pKi 6.607 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)cc2c3cccc(O)c3nc-2c1O)C(=O)C(F)(F)F CHEMBL367300 Ki 6.7 nM
COCCOC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3897616 IC50 6.7 nM
CCCCc1nnc(C(=O)[C@@H](NC(=O)Cn2c(-c3ccc(F)cc3)ncc(N)c2=O)C(C)C)o1 CHEMBL22757 Ki 6.76 nM
CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C CHEMBL2372965 Ki 6.8 nM
Cn1cc(CNC(=O)CN2C(=O)N(c3cccc(C(F)(F)F)c3)C3=C(C(=O)CC3)C2c2ccc(C#N)cc2)cn1 CHEMBL3978724 IC50 6.8 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NS(=O)(=O)CCc2ccccn2)c1=O)C(=O)C(F)(F)F CHEMBL113110 Ki 6.9 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NC1CCOC1 CHEMBL3938264 IC50 6.9 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1cn(C)cn1 CHEMBL3965921 IC50 6.9 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCc1ccc(C#N)o1 CHEMBL3940873 IC50 6.9 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N[C@H]1CCNC1 CHEMBL3894816 IC50 6.9 nM
CC(C)C(NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)cc1)C(C)C)C(=O)C(F)(F)C(F)(F)F CHEMBL138869 Ki 7.0 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NC(=O)NCc2ccccc2)c1=O)C(=O)C(F)(F)F CHEMBL113358 Ki 7.0 nM
Cn1nnnc1SCC1=C(C(=O)C(C)(C)C)N2C(=O)[C@H](Cl)C2S(=O)(=O)C1 CHEMBL128519 Ki ss 7.0 nM
COC(=O)CCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C CHEMBL130271 Ki 7.0 nM
Cc1cccc(C(=O)n2nc(C#N)c3ccccc32)c1 CHEMBL2409450 IC50 7.0 nM
CCc1cc(OC)cc2nc(-c3cccnc3N3CC[C@H](N(C)C)C3)oc(=O)c12 CHEMBL3617961 IC50 7.0 nM
CS(=O)(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2ccnc(C(F)(F)F)c2)C(=O)N1S(C)(=O)=O CHEMBL3983571 IC50 7.0 nM
Cc1cc(CNC(=O)c2cn(C(C)C)c(C)c(-c3cccc(C(F)(F)F)c3)c2=O)ccc1S(C)(=O)=O CHEMBL3916137 IC50 7.0 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N1C[C@H]2C[C@@H]1C[N+]2(C)C CHEMBL4109714 IC50 7.0 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1Br CHEMBL3966931 IC50 7.1 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCC(F)(F)F CHEMBL3924704 IC50 7.1 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N1CCn2cncc2C1 CHEMBL3935345 IC50 7.1 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NC1CCNCC1 CHEMBL3912069 IC50 7.1 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)COc1ccccc1OCC(=O)O)C(C)C)C(=O)c1nc2ccccc2o1 CHEMBL355937 IC50 7.2 nM
CS(=O)(=O)N1C(=O)N(c2cccc(C(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3922485 IC50 7.2 nM
Cc1c(-c2cccc(C(F)(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NS(C)(=O)=O)cc2)cn1C(C)C CHEMBL3964865 IC50 7.3 nM
Cc1noc(-n2cc(C(=O)NCc3ccc(S(C)(=O)=NC#N)cc3)c(=O)c(-c3cccc(C(F)(F)F)c3)c2C)c1C CHEMBL3947296 IC50 7.3 nM
CC(C)N1CCN(C(=O)c2cc(C#N)ccc2C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C)CC1 CHEMBL3926467 IC50 7.3 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N1C[C@H]2C[C@@H]1CN2 CHEMBL4110122 IC50 7.3 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1-c1ccnn1C CHEMBL3941581 IC50 7.3 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(OCC(=O)O)cc1)C(C)C)C(=O)c1nc2ccccc2o1 CHEMBL357495 IC50 7.4 nM
CN1CCC(NC(=O)c2cc(C#N)ccc2C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C)C1 CHEMBL3955908 IC50 7.4 nM
CCOCCn1c(=O)[nH]c2c(=O)n(CC(=O)NC(C(=O)C(F)(F)F)C(C)C)c(-c3ccccc3)cc2c1=O CHEMBL14165 Ki 7.5 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N1CCN2CCCC2C1 CHEMBL3954104 IC50 7.5 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N1CCNCC1 CHEMBL3938940 IC50 7.5 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](NC(=O)COc1ccc(OCC(=O)O)cc1)C(C)C)C(=O)c1nc2ccccc2o1 CHEMBL118176 IC50 7.6 nM
CCC1(CC)C(=O)N(c2ccccc2CSc2nc3ccccc3o2)C1=O CHEMBL583408 Ki 7.6 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)COc1ccc(OCC(=O)O)cc1)C(C)C)C(=O)c1nc2ccccc2o1 CHEMBL595073 IC50 7.6 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NC1CCC(O)C1 CHEMBL3980881 IC50 7.6 nM
COC(=O)Nc1cnc(-c2ccc(F)cc2)n(CC(=O)NC(B2OC(C)(C)C(C)(C)O2)C(C)C)c1=O CHEMBL267093 Ki 7.7 nM
CC(C)Sc1nc2ccccc2c(=O)o1 CHEMBL358112 pKi 7.762 nM
CC(C)[C@H](NC(=O)c1cccnc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C CHEMBL2372977 Ki 7.8 nM
Cc1c(-c2cccc(C(F)F)c2)c(=O)c(C(=O)NCc2ccc3c(c2)C=CS3(=O)=O)cn1C(C)C CHEMBL3913995 IC50 7.8 nM
Cc1cncc(-n2cc(C(=O)NCc3ccc(S(C)(=O)=NC#N)cc3)c(=O)c(-c3cccc(C(F)(F)F)c3)c2C)c1 CHEMBL3932510 IC50 7.9 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1-c1ccc2c(cnn2C)c1 CHEMBL3899104 IC50 7.9 nM
O=C(OCN1C(=O)c2ccccc2S1(=O)=O)c1c(F)cccc1F CHEMBL89299 Ki 8.0 nM
COc1cccc(OC)c1C(=O)OCN1C(=O)c2ccccc2S1(=O)=O CHEMBL88117 Ki 8.0 nM
COc1ccc(C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)c2nc3cc(NC(C)=O)ccc3o2)C(C)C)C(C)C)cc1 CHEMBL278682 Ki 8.0 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NC(=O)OCc2ccncc2)c1=O)C(=O)C(F)(F)F CHEMBL275043 Ki 8.0 nM
COc1ccc(S(=O)(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)NC(C(=O)C(F)(F)F)C(C)C)C(C)C)cc1 CHEMBL66579 Ki 8.0 nM
CO[C@H]1C(=O)N2C(C(=O)C(C)(C)C)=C(C)[C@@H](Sc3nnnn3C)S(=O)(=O)C12 CHEMBL338920 Ki ss 8.0 nM
COc1ccc(S(=O)(=O)N[C@H](C(=O)N2CCCC2C(=O)NC(C(=O)C(F)(F)F)C(C)C)C(C)C)cc1 CHEMBL293062 Ki 8.0 nM
CC[C@@H](C)n1cc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)c(=O)c(-c2cccc(C(F)F)c2)c1C CHEMBL4112917 IC50 8.0 nM
CCC(CC)n1cc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)c(=O)c(-c2cccc(C(F)(F)F)c2)c1C CHEMBL3934026 IC50 8.0 nM
CCC(CC)n1cc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)c(=O)c(-c2cccc(C(F)F)c2)c1C CHEMBL3906041 IC50 8.0 nM
Cc1c(-c2cccc(C(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=NS(C)(=O)=O)cc2)cn1C(C)C CHEMBL3956534 IC50 8.0 nM
CN1CCC(NC(=O)c2cc(C#N)ccc2C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C)CC1 CHEMBL3971464 IC50 8.0 nM
COc1ccc(-c2ncc(NC(=O)OCc3ccccc3)c(=O)n2CC(=O)NC(C(=O)C(F)(F)F)C(C)C)cc1 CHEMBL11335 Ki 8.1 nM
CCc1cccc2nc(-c3cccnc3N3CCN(C)CC3)oc(=O)c12 CHEMBL558846 IC50 8.1 nM
C[S+]([O-])c1cc(C#N)ccc1[C@H]1NC(=O)N(c2cccc(C(F)(F)F)c2)C2=C1C(=O)CC2 CHEMBL4114624 IC50 8.1 nM
COC[C@H](C)n1cc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)c(=O)c(-c2cccc(C(F)F)c2)c1C CHEMBL3910732 IC50 8.1 nM
CN1C(=O)N(c2cncc(Cl)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1S(C)(=O)=O CHEMBL3906612 IC50 8.1 nM
CCN1CCN(C(=O)c2cc(C#N)ccc2C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2C)CC1 CHEMBL3978867 IC50 8.1 nM
CCSc1nc2ccccc2c(=O)o1 CHEMBL143792 pKi 8.128 nM
CC(C)C(NC(=O)Cn1c(-c2ccc(F)cc2)ncc(NC(=O)OCc2ccccc2)c1=O)C(=O)C(F)(F)F CHEMBL11098 Ki 8.2 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2CC(=O)N2CCN3CCCC3C2)cc1 CHEMBL3968538 IC50 8.3 nM
COc1ccc(S(=O)(=O)Nc2ccc(-c3ccccc3)n(CC(=O)NC(C(=O)C(F)(F)F)C(C)C)c2=O)cc1 CHEMBL303165 Ki 8.4 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)cc2c(=O)n(CCN3CCOCC3)c(=O)[nH]c2c1=O)C(=O)C(F)(F)F CHEMBL14293 Ki 8.4 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NC1CCOCC1 CHEMBL3951312 IC50 8.4 nM
O=C(OCN1C(=O)c2ccccc2S1(=O)=O)c1c(Br)cccc1Br CHEMBL88975 Ki 8.5 nM
COc1ccc(-c2ccc(NC(=O)OCc3ccccc3)c(=O)n2CC(=O)NC(C(=O)C(F)(F)F)C(C)C)cc1 CHEMBL113171 Ki 8.5 nM
CCc1cccc2nc(-c3cccnc3N3CCN(C4CCN(C)CC4)CC3)oc(=O)c12 CHEMBL564055 IC50 8.5 nM
CCc1cccc2nc(-c3cccnc3N3CCC(C(=O)O)CC3)oc(=O)c12 CHEMBL565173 IC50 8.6 nM
Cc1cc(-n2cc(C(=O)NCc3ccc(S(C)(=O)=NC#N)cc3)c(=O)c(-c3cccc(C(F)(F)F)c3)c2C)no1 CHEMBL3893560 IC50 8.6 nM
CCNc1ccc(-c2ccccc2)n(CC(=O)NC(C(=O)C(F)(F)F)C(C)C)c1=O CHEMBL325870 Ki 8.7 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2CC(=O)N2CCN(C3CC3)CC2)cc1 CHEMBL3939005 IC50 8.7 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1-c1ccn(C)n1 CHEMBL3910592 IC50 8.7 nM
CC(C)[C@H](NC(=O)Cn1c(-c2ccccc2)ncc(N)c1=O)C(=O)c1nnc(C2(C)CC2)o1 CHEMBL279296 Ki 8.75 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NC(=O)OCc2ccccn2)c1=O)C(=O)C(F)(F)F CHEMBL113905 Ki 8.8 nM
CC(=O)C1=C(C)N(c2cccc(C(F)(F)F)c2)C(=O)N(C)C1c1ccc(C#N)cc1C(=O)N1CCN(C2CC2)CC1 CHEMBL3926771 IC50 8.8 nM
CN1C(=O)N(c2cncc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1S(C)(=O)=O CHEMBL3917643 IC50 8.8 nM
CCCNC(=O)C(F)(F)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(OC)cc1)C(C)C)C(C)C CHEMBL105981 Ki 8.9 nM
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)COc1ccc(OCC(=O)O)cc1)C(C)C)C(=O)c1nc2c(OC(=O)C(C)(C)C)cccc2o1 CHEMBL358943 IC50 8.9 nM
CC[S+]([O-])c1cc(C#N)ccc1[C@@H]1NC(=O)N(c2cccc(C(F)(F)F)c2)C2=C1C(=O)CC2 CHEMBL3954338 IC50 8.9 nM
CC(C)C(NC(=O)Cn1c(-c2ccc(NC=O)cc2)ncc(NC(=O)OCc2ccccc2)c1=O)C(=O)C(F)(F)F CHEMBL11347 Ki 9.0 nM
CC[C@H](C)n1cc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)c(=O)c(-c2cccc(C(F)(F)F)c2)c1C CHEMBL3939345 IC50 9.0 nM
COC[C@H](C)n1cc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)c(=O)c(-c2cccc(C(F)(F)F)c2)c1C CHEMBL3943081 IC50 9.0 nM
CC(C)C(NC(=O)Cn1c(-c2cccnc2)ccc(NC(=O)OCc2ccccc2)c1=O)C(=O)C(F)(F)F CHEMBL418822 Ki 9.1 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2CC(=O)NCC2CCOC2)cc1 CHEMBL3890309 IC50 9.1 nM
CC(C(=O)NCCO)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3962375 IC50 9.1 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NS(C)(=O)=O)c1=O)C(=O)C(F)(F)F CHEMBL111955 Ki 9.3 nM
CS(=O)(=O)N1C(=O)N(c2cccc(C(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1Cl CHEMBL3934000 IC50 9.3 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NS(=O)(=O)c2ccc(C(=O)NS(=O)(=O)c3ccc(Cl)cc3)cc2)c1=O)C(=O)C(F)(F)F CHEMBL303493 Ki 9.4 nM
CC(=O)Nc1cccc(S(=O)(=O)Nc2ccc(-c3ccccc3)n(CC(=O)NC(C(=O)C(F)(F)F)C(C)C)c2=O)c1 CHEMBL114868 Ki 9.4 nM
C[S+]([O-])c1cc(C#N)ccc1[C@@H]1NC(=O)N(c2cccc(C(F)(F)F)c2)C2=C1C(=O)CC2 CHEMBL3953171 IC50 9.4 nM
CN1C(=O)N(c2cccc(C(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1 CHEMBL3964780 IC50 9.4 nM
Cc1cc(-n2cc(C(=O)NCc3ccc(S(C)(=O)=NC#N)cc3)c(=O)c(-c3cccc(C(F)(F)F)c3)c2C)on1 CHEMBL3973416 IC50 9.4 nM
Cc1nnc(CNC(=O)CN2C(=O)N(c3cccc(C(F)(F)F)c3)C3=C(C(=O)CC3)C2c2ccc(C#N)cc2)o1 CHEMBL3901620 IC50 9.5 nM
COc1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C CHEMBL3978243 IC50 9.5 nM
CN1C(=O)N(c2cc(C(F)(F)F)ccn2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1S(C)(=O)=O CHEMBL3945537 IC50 9.5 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)NCC(C)(C)O CHEMBL3937142 IC50 9.5 nM
COP(=O)(OC)c1ccc2nc3c(O)n(CC(=O)NC(C(=O)C(F)(F)F)C(C)C)c(-c4ccccc4)cc-3c2c1 CHEMBL174802 Ki 9.6 nM
N#Cc1ccc(C2C3=C(CCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2CC(=O)NCC2CCOCC2)cc1 CHEMBL3944242 IC50 9.7 nM
CN1CC(CNC(=O)CN2C(=O)N(c3cccc(C(F)(F)F)c3)C3=C(C(=O)CC3)C2c2ccc(C#N)cc2)CC1=O CHEMBL3951195 IC50 9.7 nM
CS(=O)(=O)c1cc(C#N)ccc1C1NC(=O)N(c2cccc(C(F)F)c2)C2=C1C(=O)CC2 CHEMBL3915980 IC50 9.7 nM
CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1C(=O)N1CCc2nocc2C1 CHEMBL3986983 IC50 9.8 nM
CC(C)C(NC(=O)Cn1c(-c2ccccc2)cc2c(=O)n(CC(=O)NCc3ccccc3)c(=O)[nH]c2c1=O)C(=O)C(F)(F)F CHEMBL275340 Ki 9.9 nM