O=C1Nc2ccc(-c3ccn[nH]3)cc2[C@](CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 CHEMBL570571 IC50 2.6 nM
O=C1Nc2ccc(-c3ccn[nH]3)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 CHEMBL571707 IC50 4.0 nM
Cc1ccc(-n2[nH]c(C)c(C3(C(F)(F)F)C(=O)N(c4ccccc4)C4=C3C(=O)CC(C)(C)C4)c2=O)cc1 CHEMBL490110 IC50 8.7 nM
Cc1[nH]n(-c2ccc(OC(F)(F)F)cc2)c(=O)c1C1(C(F)(F)F)C(=O)N(c2ccccc2)C2=C1C(=O)CC(C)(C)C2 CHEMBL449121 IC50 8.9 nM
Cc1[nH]n(-c2ccc(C(C)C)cc2)c(=O)c1C1(C(F)(F)F)C(=O)N(c2ccccc2)C2=C1C(=O)CC(C)(C)C2 CHEMBL493642 IC50 10.0 nM
O=C1Nc2ccc(-c3cn[nH]c3)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 CHEMBL571698 IC50 10.0 nM
Cc1[nH]n(-c2ccc(Cl)cc2)c(=O)c1C1(C(F)(F)F)C(=O)N(c2ccccc2)C2=C1C(=O)CC(C)(C)C2 CHEMBL490750 IC50 12.0 nM
O=C1Nc2ccc(-n3cccn3)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 CHEMBL585922 IC50 13.0 nM
Cc1[nH]n(-c2ccc(C#N)cc2)c(=O)c1C1(C(F)(F)F)C(=O)N(c2ccccc2)C2=C1C(=O)CC(C)(C)C2 CHEMBL491949 IC50 14.0 nM
O=C1Nc2ccc(Cl)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 CHEMBL572158 IC50 15.0 nM
COc1ccc(-n2[nH]c(C)c(C3(C(F)(F)F)C(=O)N(c4ccccc4)C4=C3C(=O)CC(C)(C)C4)c2=O)cc1 CHEMBL491944 IC50 17.0 nM
O=C(NCC1(C(F)(F)F)OC(=O)Nc2ccc(Cl)cc21)Nc1ccc(F)cc1 CHEMBL570576 IC50 19.0 nM
CC(C)c1ccc(NC(=O)N2[C@@H]3CC[C@H]2C[C@@H](S(=O)(=O)c2ccccc2)C3)cc1 CHEMBL2307408 IC50 32.0 nM
Cc1ccc(C(=O)NCC2(C(F)(F)F)OC(=O)Nc3ccc(Cl)cc32)cc1 CHEMBL582825 IC50 38.0 nM
O=C1Nc2ccc(N3CCCC3=O)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 CHEMBL576264 IC50 39.0 nM
COc1cccc(-n2[nH]c(C)c(C3(C(F)(F)F)C(=O)N(c4ccccc4)C4=C3C(=O)CC(C)(C)C4)c2=O)c1 CHEMBL521775 IC50 43.0 nM
Cc1[nH]n(-c2cccc(Cl)c2)c(=O)c1C1(C(F)(F)F)C(=O)N(c2ccccc2)C2=C1C(=O)CC(C)(C)C2 CHEMBL491921 IC50 44.0 nM
Cc1[nH]n(-c2ccc(F)cc2)c(=O)c1C1(C(F)(F)F)C(=O)N(c2ccccc2)C2=C1C(=O)CC(C)(C)C2 CHEMBL491948 IC50 44.0 nM
COc1ccccc1-n1[nH]c(C)c(C2(C(F)(F)F)C(=O)N(c3ccccc3)C3=C2C(=O)CC(C)(C)C3)c1=O CHEMBL490760 IC50 58.0 nM
CC(C)Oc1ccc(NC(=O)[C@@H]2C[C@@H]3CC[C@@H]2N(S(=O)(=O)c2ccsc2)C3)cc1 CHEMBL575156 IC50 67.0 nM
O=C1Nc2ccc(N3CCOC3=O)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 CHEMBL569399 IC50 67.0 nM
CC(C)Oc1ccc(NC(=O)[C@@H]2C[C@@H]3CC[C@@H]2N(S(=O)(=O)c2ccccc2)C3)cc1 CHEMBL573551 IC50 70.0 nM
C=C(Nc1ccc(C(C)(C)C)cc1)N1C2CC[C@@H]1CC(S(=O)(=O)c1ccccc1)C2 CHEMBL1163008 IC50 78.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1[C@@H]2CC[C@H]1C[C@@H](S(=O)(=O)c1ccccn1)C2 CHEMBL2308139 IC50 79.0 nM
CC(C)Oc1ccc(NC(=O)[C@@H]2C[C@@H]3CC[C@@H]2N(S(=O)(=O)c2cccnc2)C3)cc1 CHEMBL572610 IC50 80.0 nM
O=C1Nc2ccccc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 CHEMBL566967 IC50 95.0 nM
O=C1Nc2ccc(-c3ncn[nH]3)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 CHEMBL583468 IC50 97.0 nM
CCc1[nH]n(-c2ccccc2)c(=O)c1C1(C(F)(F)F)C(=O)N(c2ccccc2)C2=C1C(=O)CC(C)(C)C2 CHEMBL491131 IC50 99.0 nM
O=C1Nc2ccc(-n3ccccc3=O)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 CHEMBL570564 IC50 106.0 nM
CC(C)Oc1ccc(NC(=O)[C@@H]2C[C@@H]3CC[C@@H]2N(S(=O)(=O)c2cccc(F)c2)C3)cc1 CHEMBL577160 IC50 110.0 nM
CCCCS(=O)(=O)N1C[C@H]2CC[C@H]1[C@H](C(=O)Nc1ccc(OC(C)C)cc1)C2 CHEMBL572605 IC50 120.0 nM
CC(C)Oc1ccc(NC(=O)[C@@H]2C[C@@H]3CC[C@@H]2N(S(=O)(=O)c2ccccn2)C3)cc1 CHEMBL579051 IC50 120.0 nM
O=C1Nc2ccc(-c3ccon3)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 CHEMBL584964 IC50 121.0 nM
Cc1[nH]n(-c2ccccc2)c(=O)c1C1(C(F)(F)F)C(=O)N(c2ccccc2)C2=C1C(=O)CC1(CCC1)C2 CHEMBL523990 IC50 123.0 nM
CC(C)Oc1ccc(NC(=O)[C@@H]2C[C@@H]3CC[C@@H]2N(S(=O)(=O)c2ccccc2F)C3)cc1 CHEMBL578037 IC50 130.0 nM
O=C(Nc1ccc(F)cc1)OCC1(C(F)(F)F)OC(=O)Nc2ccc(Cl)cc21 CHEMBL578605 IC50 142.0 nM
Cc1[nH]n(-c2ccccc2)c(=O)c1C1(C(F)(F)F)C(=O)N(C2CC2)C2=C1C(=O)CC(C)(C)C2 CHEMBL470918 IC50 144.0 nM
CCCN1C(=O)C(c2c(C)[nH]n(-c3ccccc3)c2=O)(C(F)(F)F)C2=C1CC(C)(C)CC2=O CHEMBL470730 IC50 185.0 nM
CC(C)Oc1ccc(NC(=O)[C@@H]2C[C@@H]3CC[C@@H]2N(S(=O)(=O)c2ccc(F)cc2)C3)cc1 CHEMBL574029 IC50 190.0 nM
Cc1[nH]n(-c2ccc(Oc3ccccc3)cc2)c(=O)c1C1(C(F)(F)F)C(=O)N(c2ccccc2)C2=C1C(=O)CC(C)(C)C2 CHEMBL447672 IC50 196.0 nM
Cc1[nH]n(-c2ccccc2)c(=O)c1C1(C(F)(F)F)C(=O)N(C2CCCCC2)C2=C1C(=O)CC(C)(C)C2 CHEMBL490746 IC50 210.0 nM
CCCS(=O)(=O)N1C[C@H]2CC[C@H]1[C@H](C(=O)Nc1ccc(OC(C)C)cc1)C2 CHEMBL575155 IC50 210.0 nM
CC(C)Oc1ccc(NC(=O)C2CC3CCC2N(S(=O)(=O)c2cn(C)cn2)C3)cc1 CHEMBL574934 IC50 220.0 nM
COc1cccc(N2C(=O)C(c3c(C)[nH]n(-c4ccccc4)c3=O)(C(F)(F)F)C3=C2CC(C)(C)CC3=O)c1 CHEMBL489920 IC50 226.0 nM
CC(C)Oc1ccc(NC(=O)[C@@H]2C[C@@H]3CC[C@@H]2N(S(=O)(=O)c2cn(C)cn2)C3)cc1 CHEMBL578249 IC50 230.0 nM
Cc1[nH]n(-c2ccccc2)c(=O)c1C1(C(F)(F)F)C(=O)N(c2cccc(Cl)c2)C2=C1C(=O)CC(C)(C)C2 CHEMBL491125 IC50 245.0 nM
O=C1Nc2ccc(Cl)cc2C(CNC(=O)c2cccc(F)c2)(C(F)(F)F)O1 CHEMBL574146 IC50 261.0 nM
Cc1[nH]n(-c2ccccc2)c(=O)c1C1(C(F)(F)F)C(=O)N(C2CCC2)C2=C1C(=O)CC(C)(C)C2 CHEMBL474835 IC50 271.0 nM
Cc1[nH]n(-c2ccccc2)c(=O)c1C1(C(F)(F)F)C(=O)N(c2ccccc2)C2=C1C(=O)CC(C)(C)C2 CHEMBL491537 IC50 290.0 nM
CC(C)Oc1ccc(NC(=O)[C@@H]2C[C@@H]3CC[C@@H]2N(S(=O)(=O)c2cccs2)C3)cc1 CHEMBL574479 IC50 320.0 nM
Cc1[nH]n(-c2ccccc2)c(=O)c1C1(C(F)(F)F)C(=O)N(C2CCCC2)C2=C1C(=O)CC(C)(C)C2 CHEMBL491371 IC50 411.0 nM
Cc1cccc(C(=O)NCC2(C(F)(F)F)OC(=O)Nc3ccc(Cl)cc32)c1 CHEMBL569176 IC50 437.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1[C@@H]2CC[C@H]1C[C@@H](S(=O)(=O)c1ccncc1)C2 CHEMBL2308143 IC50 510.0 nM
CCCCS(=O)(=O)N1C[C@H]2CC[C@H]1[C@H](C(=O)Nc1ccc(OC(F)(F)F)cc1)C2 CHEMBL574936 IC50 510.0 nM
Cc1[nH]n(-c2ccccc2)c(=O)c1C1(C(F)(F)F)C(=O)N(C)C2=C1C(=O)CC(C)(C)C2 CHEMBL522448 IC50 520.0 nM
O=C1Nc2ccc(-c3ncc[nH]3)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 CHEMBL566966 IC50 537.0 nM
O=C1Nc2ccc(Cl)cc2C(CNC(=O)c2ccccc2F)(C(F)(F)F)O1 CHEMBL572159 IC50 539.0 nM
CCN1C(=O)C(c2c(C)[nH]n(-c3ccccc3)c2=O)(C(F)(F)F)C2=C1CC(C)(C)CC2=O CHEMBL452144 IC50 550.0 nM
COc1ccc(C(=O)NCC2(C(F)(F)F)OC(=O)Nc3ccc(Cl)cc32)cc1 CHEMBL583523 IC50 558.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1[C@@H]2CC[C@H]1C[C@@H](S(=O)(=O)c1cccnc1)C2 CHEMBL2307419 IC50 560.0 nM
COc1ccc(N2C(=O)C(c3c(C)[nH]n(-c4ccccc4)c3=O)(C(F)(F)F)C3=C2CC(C)(C)CC3=O)cc1 CHEMBL521776 IC50 566.0 nM
O=C1Nc2ccc(-n3cncn3)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 CHEMBL568728 IC50 572.0 nM
Cc1[nH]n(-c2ccccc2)c(=O)c1C1(C(F)(F)F)C(=O)N(C(C)C)C2=C1C(=O)CC(C)(C)C2 CHEMBL513730 IC50 600.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1[C@@H]2CC[C@H]1C[C@@H](S(=O)(=O)c1cccc(Cl)c1)C2 CHEMBL2306677 IC50 600.0 nM
COc1cccc(S(=O)(=O)N2C[C@H]3CC[C@H]2[C@H](C(=O)Nc2ccc(OC(C)C)cc2)C3)c1 CHEMBL577360 IC50 600.0 nM
Cc1[nH]n(-c2ccccc2)c(=O)c1C1(C(F)(F)F)C(=O)N(c2ccc(Cl)cc2)C2=C1C(=O)CC(C)(C)C2 CHEMBL521763 IC50 603.0 nM
COc1ccc(S(=O)(=O)N2C[C@H]3CC[C@H]2[C@H](C(=O)Nc2ccc(OC(C)C)cc2)C3)cc1 CHEMBL573079 IC50 610.0 nM
CC(C)Oc1ccc(NC(=O)[C@@H]2C[C@@H]3CC[C@@H]2N(S(=O)(=O)C(C)C)C3)cc1 CHEMBL572608 IC50 620.0 nM
O=C(Cc1ccc(F)cc1)NCC1(C(F)(F)F)OC(=O)Nc2ccc(Cl)cc21 CHEMBL583461 IC50 648.0 nM
Cc1[nH]n(-c2ccccc2)c(=O)c1C1(C(F)(F)F)C(=O)N(c2ccccc2)C2=C1C(=O)CC(C)C2 CHEMBL522979 IC50 704.0 nM
CCCCS(=O)(=O)N1C[C@H]2CC[C@H]1[C@H](C(=O)Nc1ccc(Oc3ccccc3)cc1)C2 CHEMBL574937 IC50 710.0 nM
O=C1Nc2ccc(Cl)cc2C(CNC(=O)c2ccc(C(F)(F)F)cc2)(C(F)(F)F)O1 CHEMBL566965 IC50 813.0 nM
CCCCS(=O)(=O)N1C[C@H]2CC[C@H]1[C@H](C(=O)Nc1ccc(Cc3ccccc3)cc1)C2 CHEMBL578446 IC50 830.0 nM
COc1cccc(S(=O)(=O)[C@H]2C[C@H]3CC[C@@H](C2)N3C(=O)Nc2ccc(C(F)(F)F)cc2)c1 CHEMBL2306674 IC50 840.0 nM
Cc1[nH]n(-c2ccccc2)c(=O)c1C1(C(F)(F)F)C(=O)N(Cc2ccccc2)C2=C1C(=O)CC(C)(C)C2 CHEMBL490747 IC50 879.0 nM
CCCCS(=O)(=O)N1CCCC(C(=O)Nc2ccc(OC(C)C)cc2)C1 CHEMBL572606 IC50 930.0 nM
O=C(Nc1ccc(Cl)cc1)N1[C@@H]2CC[C@H]1C[C@@H](S(=O)(=O)c1ccccc1)C2 CHEMBL2306668 IC50 970.0 nM
Cc1ccccc1C(=O)NCC1(C(F)(F)F)OC(=O)Nc2ccc(Cl)cc21 CHEMBL569177 IC50 971.0 nM