Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO[P@@](O)(=S)OP(=O)(O)CP(=O)(O)O)[C@@H](O)[C@H]1O CHEMBL3289393 Ki -71500.0 nM
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO[P@](O)(=S)OP(=O)(O)C(Cl)(Cl)P(=O)(O)O)[C@@H](O)[C@H]1O CHEMBL3289394 Ki -12500.0 nM
Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)CP(=O)(O)OP(O)(O)=S)[C@@H](O)[C@H]1O CHEMBL3289396 Ki -9000.0 nM
CN1Cc2c(ncnc2N2CCC(C)(CNS(N)(=O)=O)CC2)NC1=O CHEMBL5282123 IC50 3.7 nM
COc1ccc(NC(=O)CSc2nc3c(N)ncnc3[nH]2)cc1OC CHEMBL3360892 Ki 5.0 nM
COc1ccc2c(-c3ccc(CNS(N)(=O)=O)cc3)ccnc2c1 CHEMBL5411127 IC50 11.0 nM
COc1ccc(NC(=O)CSc2nc3c(=O)[nH]cnc3[nH]2)cc1OC CHEMBL3360893 Ki 20.0 nM
O=c1ccn([C@@H]2O[C@H](COP(=S)(S)OP(=O)(O)OP(=O)(O)OP(=S)(S)OC[C@H]3O[C@@H](n4ccc(=O)[nH]c4=O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1 CHEMBL4206625 Ki 27.0 nM
COc1ccc2nc(SCC(=O)Nc3ccc(OC)c(OC)c3)[nH]c2n1 CHEMBL3360884 Ki 29.6 nM
CN1Cc2c(-c3ccc(CNS(N)(=O)=O)c(F)c3)ccnc2NC1=O CHEMBL5278177 IC50 32.3 nM
COc1ccc(NC(=O)CSc2nc3c(=O)[nH]c(=O)[nH]c3[nH]2)cc1OC CHEMBL3360901 Ki 35.8 nM
COc1cc2c(-c3ccc(CNS(N)(=O)=O)cc3)n[nH]c(=O)c2cc1OC CHEMBL5433453 IC50 37.0 nM
NS(=O)(=O)Nc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1 CHEMBL5438954 IC50 39.0 nM
COc1ccc(NC(=O)CSc2nc3cnccc3[nH]2)cc1OC CHEMBL3360878 Ki 44.2 nM
CN1Cc2c(NCc3ccc(NS(N)(=O)=O)cc3)ncnc2NC1=O CHEMBL5287511 IC50 45.0 nM
CN1Cc2c(ncnc2N2CCC(CNS(N)(=O)=O)CC2)NC1=O CHEMBL5282991 IC50 48.0 nM
COc1cc2nc(/C=C/c3cccnc3)nc(N3CCC(CCNS(N)(=O)=O)CC3)c2cc1OC CHEMBL1783614 Ki 58.0 nM
COc1cc2ncnc(N3CCC(CCNS(N)(=O)=O)CC3)c2cc1OC CHEMBL1783609 Ki 59.0 nM
Cn1nc(Cc2ccc(NS(N)(=O)=O)cc2)c2ccccc2c1=O CHEMBL5413273 IC50 68.0 nM
COc1cc2c(Cc3ccc(NS(N)(=O)=O)cc3)n[nH]c(=O)c2cc1OC CHEMBL5426250 IC50 69.0 nM
COc1cc2nc(/C=C/c3ccccn3)nc(N3CCC(CCNS(N)(=O)=O)CC3)c2cc1OC CHEMBL4160816 Ki 71.0 nM
COc1cc2nc(CC3OC(=O)c4ccccc43)nc(N3CCC(CCNS(N)(=O)=O)CC3)c2cc1OC CHEMBL4163119 Ki 90.0 nM
COc1cccc(/C=C/c2nc(N3CCC(CCNS(N)(=O)=O)CC3)c3cc(OC)c(OC)cc3n2)c1 CHEMBL4163923 Ki 101.0 nM
COc1cc2c(Cc3ccc(NS(N)(=O)=O)cc3)nn(C)c(=O)c2cc1OC CHEMBL5418681 IC50 118.0 nM
COc1ccc(NC(=O)CSc2nc3c(C)ccnc3[nH]2)cc1OC CHEMBL3360885 Ki 127.0 nM
COc1ccc(NC(=O)CSc2nc3nccnc3[nH]2)cc1OC CHEMBL3360880 Ki 131.0 nM
COc1ccc(NC(=O)CSc2nc3cc(Cl)cnc3[nH]2)cc1OC CHEMBL3360882 Ki 137.0 nM
NS(=O)(=O)NCc1ccc(-c2n[nH]c(=O)c3ccccc23)cc1 CHEMBL5440717 IC50 139.0 nM
CCOc1ccccc1-c1nc(-c2ccc(-c3cccc4ccccc34)cc2)co1 CHEMBL4747297 IC50 150.0 nM
COc1ccc(NC(=O)CSc2nc3c(N)nc(SC)nc3[nH]2)cc1OC CHEMBL3360899 Ki 152.0 nM
CN1Cc2c(ncnc2N2CCC3(CC2)CCN(S(N)(=O)=O)C3)NC1=O CHEMBL5279977 IC50 164.0 nM
COc1cc2c(Cc3ccc(N(C)S(N)(=O)=O)cc3)n[nH]c(=O)c2cc1OC CHEMBL5437224 IC50 166.0 nM
CN1Cc2c(ncnc2-c2cccc(CNS(N)(=O)=O)c2)NC1=O CHEMBL5280052 IC50 171.0 nM
FC(F)(F)c1nc2c(-c3ccccc3)cccc2c(-c2ccccc2)c1-c1ccccc1 CHEMBL4169839 IC50 180.0 nM
COc1ccc(-c2nn(-c3cccc(NS(=O)(=O)c4ccc(C)cc4)c3)cc2-c2ccncc2)cc1Cl CHEMBL4878720 IC50 180.0 nM
COc1ccc(NC(=O)CSc2nc3cc(Br)cnc3[nH]2)cc1OC CHEMBL3360883 Ki 192.0 nM
COc1cc2c(Cc3ccc4c(c3)CCN4S(N)(=O)=O)nn(C)c(=O)c2cc1OC CHEMBL5409520 IC50 207.0 nM
COc1cc2c(Cc3ccc4c(c3)CCN4S(N)(=O)=O)n[nH]c(=O)c2cc1OC CHEMBL5410089 IC50 210.0 nM
COc1cc2nc(/C=C/c3ccccc3F)nc(N3CCC(CCNS(N)(=O)=O)CC3)c2cc1OC CHEMBL4174875 Ki 211.0 nM
COc1ccc(NC(=O)CSc2nc3ccc[nH]c-3n2)cc1OC CHEMBL1433061 Ki 217.0 nM
COc1cc2nc(/C=C/c3ccncc3)nc(N3CCC(CCNS(N)(=O)=O)CC3)c2cc1OC CHEMBL4164216 Ki 218.0 nM
COc1ccc(/C=C/c2nc(N3CCC(CCNS(N)(=O)=O)CC3)c3cc(OC)c(OC)cc3n2)cc1 CHEMBL4166272 Ki 231.0 nM
CN1Cc2c(ncnc2N2CCC(C)(NS(N)(=O)=O)CC2)NC1=O CHEMBL5287838 IC50 236.0 nM
O=c1ccn([C@@H]2O[C@H](COP(=S)(S)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]1 CHEMBL4218881 Ki 240.0 nM
COc1ccc2ncnc(N3CCC(CCNS(N)(=O)=O)CC3)c2c1 CHEMBL4162412 Ki 242.0 nM
COc1cc2c(Cc3ccc(N(C)S(N)(=O)=O)cc3)nn(C)c(=O)c2cc1OC CHEMBL5415314 IC50 247.0 nM
COc1ccc(OC)c(-c2cccc3c(Cl)c(Br)c(C(F)(F)F)nc23)c1 CHEMBL4162261 IC50 250.0 nM
CC1=CCC(C(=O)/N=C2\CC=C(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c32)=C/C1=N/C(=O)C1=CC=C/C(=N\C(=O)/N=C2\C=CC=C(C(=O)/N=C3/CC(C(=O)/N=C4\CC=C(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c54)=CC=C3C)C2)C1 CHEMBL3040216 Ki 260.0 nM
NS(=O)(=O)Nc1ccc(Cc2n[nH]c(=O)c3ccccc23)c(F)c1 CHEMBL5417400 IC50 273.0 nM
COc1ccc(NC(=O)CSc2nc3cncnc3[nH]2)cc1OC CHEMBL3360879 Ki 281.0 nM
Cn1nc(-c2ccc(CNS(N)(=O)=O)cc2)c2ccccc2c1=O CHEMBL5431781 IC50 286.0 nM
CC(C)(C)c1ccc(S(=O)(=O)Oc2ccc(-c3sc4cc(OS(=O)(=O)c5ccc(C(C)(C)C)cc5)ccc4c3C(=O)c3ccc(OCCN4CCCCC4)cc3)cc2)cc1 CHEMBL4473374 IC50 290.0 nM
COC(=O)c1cccc(/C=C/c2nc(N3CCC(CCNS(N)(=O)=O)CC3)c3cc(OC)c(OC)cc3n2)c1 CHEMBL4159456 Ki 297.0 nM
NS(=O)(=O)Nc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1F CHEMBL5438817 IC50 298.0 nM
COc1ccccc1/C=C/c1nc(N2CCC(CCNS(N)(=O)=O)CC2)c2cc(OC)c(OC)cc2n1 CHEMBL4174575 Ki 302.0 nM
FC(F)(F)c1ccc(-c2cccc3c(Cl)c(Br)c(C(F)(F)F)nc23)cc1 CHEMBL4172790 IC50 310.0 nM
Cc1cc(C)cc(-c2nn3c(=O)c(F)c(C)nc3s2)c1 CHEMBL4284270 IC50 310.0 nM
CN1Cc2c(-c3ccc(CNS(N)(=O)=O)cc3)ccnc2N(C)C1=O CHEMBL5276377 IC50 326.0 nM
N#Cc1cccc(-c2cccc3c(Cl)c(Br)c(C(F)(F)F)nc23)c1 CHEMBL4164891 IC50 350.0 nM
COc1cc2cc(-n3cc(C)c4ccccc43)n3c4ccccc4c(C)c3c2cc1OC CHEMBL4292174 IC50 360.0 nM
CN1Cc2c(ncnc2-c2cccc(NS(N)(=O)=O)c2)NC1=O CHEMBL5272310 IC50 360.0 nM
COc1cc2nc(CCc3ccc(F)cc3)nc(N3CCC(CCNS(N)(=O)=O)CC3)c2cc1OC CHEMBL4171038 Ki 366.0 nM
NS(=O)(=O)NCc1ccc(-c2n[nH]c(=O)c3ccccc23)cc1C(F)(F)F CHEMBL5432577 IC50 377.0 nM
O=C(Nc1ccc(OS(=O)(=O)c2ccc(C(F)(F)F)cc2)cc1)C1CCCCC1 CHEMBL4467712 IC50 387.0 nM
CN1Cc2c(-c3ccc(CNS(N)(=O)=O)cc3)ccnc2NC1=O CHEMBL5290907 IC50 389.0 nM
COc1ccc(-c2cccc3c(Cl)c(Br)c(C(F)(F)F)nc23)cc1 CHEMBL4172933 IC50 390.0 nM
COc1cc2c(N3CCC(CNS(N)(=O)=O)CC3)n[nH]c(=O)c2cc1OC CHEMBL5410186 IC50 395.0 nM
COc1ccc(S(=O)(=O)Oc2ccc(-c3sc4cc(OS(=O)(=O)c5ccc(OC)cc5)ccc4c3C(=O)c3ccc(OCCN4CCCCC4)cc3)cc2)cc1 CHEMBL4589775 IC50 420.0 nM
Cc1ccccc1-c1ccc(-c2coc(-c3ccccc3)n2)cc1 CHEMBL4793019 IC50 420.0 nM
Cc1ccc(S(=O)(=O)Oc2ccc(NC(=O)C3CCCCCC3)cc2)cc1 CHEMBL4451311 IC50 422.0 nM
O=C(Nc1ccc(OS(=O)(=O)c2ccc(C(F)(F)F)cc2)cc1)C1CCCCCC1 CHEMBL4519236 IC50 431.0 nM
NS(=O)(=O)NCC1CCN(c2n[nH]c(=O)c3ccccc23)CC1 CHEMBL5404533 IC50 441.0 nM
Cc1ccc(S(=O)(=O)Oc2ccc(-c3sc4cc(OS(=O)(=O)c5ccc(C)cc5)ccc4c3C(=O)c3ccc(OCCN4CCCCC4)cc3)cc2)cc1 CHEMBL4456605 IC50 450.0 nM
CN1Cc2c(ncnc2-c2ccc(CNS(N)(=O)=O)cc2)NC1=O CHEMBL5285218 IC50 452.0 nM
COc1cc2c(N3CCC(CNS(N)(=O)=O)CC3)nn(C)c(=O)c2cc1OC CHEMBL5404767 IC50 454.0 nM
COc1cc2nc(/C=C/c3ccc(F)cc3)nc(N3CCC(CCNS(N)(=O)=O)CC3)c2cc1OC CHEMBL4159758 Ki 465.0 nM
O=c1/c(=C/c2ccc(I)o2)sc2nc3ccccc3n12 CHEMBL3813806 Ki 467.0 nM
B[P@@](=O)(OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)OP(=O)(O)CP(=O)(O)O CHEMBL3087158 Ki(app) 500.0 nM
Fc1ccc(-c2c(C(F)(F)F)nc3c(-c4ccc(F)cc4)cccc3c2-c2ccc(F)cc2)cc1 CHEMBL4164185 IC50 510.0 nM
Nc1c(S(=O)(=O)O)cc(Nc2ccc(Nc3nc(Cl)nc(Nc4cccc(S(=O)(=O)O)c4)n3)c(S(=O)(=O)O)c2)c2c1C(=O)c1ccccc1C2=O CHEMBL1160031 Ki 520.0 nM
CN1Cc2c(-c3cccc(CNS(N)(=O)=O)c3)ccnc2NC1=O CHEMBL5275034 IC50 525.0 nM
O=C(Nc1ccc(OS(=O)(=O)c2ccc(F)cc2)cc1)C1CCCCC1 CHEMBL4585698 IC50 564.0 nM
COc1ccc2c(-c3ccc(CNS(N)(=O)=O)cc3)n[nH]c(=O)c2c1 CHEMBL5431402 IC50 590.0 nM
O=c1/c(=C/c2ccc(Br)o2)sc2nc3ccccc3n12 CHEMBL3814399 Ki 610.0 nM
O=c1c(Br)c(C(F)(F)F)[nH]c2c(Br)cccc12 CHEMBL4175913 IC50 630.0 nM
CN1Cc2c(ncnc2N2CCC(C)(CCNS(N)(=O)=O)CC2)NC1=O CHEMBL5286609 IC50 669.0 nM
COc1cc2ncnc(N3CCC(CCN)CC3)c2cc1OC CHEMBL4168465 Ki 699.0 nM
Cc1ccc(-c2c(C(F)(F)F)nc3c(-c4ccc(C)cc4)cccc3c2-c2ccc(C)cc2)cc1 CHEMBL4173693 IC50 730.0 nM
O=c1ccn(COCCOP(=S)(S)OP(=O)(O)C(Cl)(Cl)P(=O)(O)O)c(=O)[nH]1 CHEMBL4465876 Ki 730.0 nM
CN1Cc2c(ncnc2N2CCC(NS(N)(=O)=O)CC2)NC1=O CHEMBL5289139 IC50 759.0 nM
CN1Cc2c(-c3cccc(NS(N)(=O)=O)c3)ccnc2NC1=O CHEMBL5278671 IC50 766.0 nM
CN1Cc2c(ncnc2N2CCC(CCNS(N)(=O)=O)CC2)NC1=O CHEMBL5279855 IC50 773.0 nM
O=C(NS(=O)(=O)c1cccc([N+](=O)[O-])c1)n1ccc2cccnc21 CHEMBL4875454 IC50 800.0 nM
CN1Cc2c(ncnc2-c2ccc(CNS(N)(=O)=O)c(F)c2)NC1=O CHEMBL5274733 IC50 916.0 nM
O=c1ccn(COCCOP(=S)(S)OP(=O)(O)CP(=O)(O)O)c(=O)[nH]1 CHEMBL4443638 Ki 940.0 nM
CC(C)c1cc(C(C)C)c(S(=O)(=O)Oc2ccc(NC(=O)c3ccc(Cl)cc3)cc2)c(C(C)C)c1 CHEMBL4467551 IC50 975.0 nM
O=c1/c(=C/c2ccco2)sc2nc3ccccc3n12 CHEMBL2006050 Ki 981.0 nM