CCc1nc2c(C)cc(N3CCN(CC(=O)N4CC(O)C4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)c(C#N)s1 CHEMBL3828074 IC50 0.01 nM
CCn1cc(NC(=O)OCc2cc(Cl)cc(Cl)c2)c2cc(-c3nc(CN4CCOCC4)cs3)ccc21 CHEMBL5183599 IC50 0.41 nM
CCn1cc(NC(=O)OCc2cc(Cl)cc(Cl)c2)c2cc(-c3nc(CN4CCN(CCO)CC4)cs3)ccc21 CHEMBL4640012 IC50 0.43 nM
NS(=O)(=O)c1ccc(C(=O)N2C[C@H]3CN(C(=O)OCc4ccc(OC(F)(F)F)cc4)C[C@@H]3C2)cc1F CHEMBL3828650 IC50 1.0 nM
C[C@H](NC(=O)CCc1nc2cccnc2n1Cc1ccc(OC(F)(F)F)cc1)c1ccc(Cl)cc1 CHEMBL3917975 IC50 1.0 nM
C[C@@H](c1ccc2ccc(O[C@H]3CC[C@@H](C(F)(F)F)CC3)c(C(F)(F)F)c2c1)N1C2CCC1CC(C(=O)O)C2 CHEMBL4871014 IC50 1.0 nM
CCn1cc(NC(=O)OCc2ccc(F)c(F)c2)c2cc(-c3nc(CN4CCC(O)CC4)cs3)ccc21 CHEMBL4647222 IC50 1.01 nM
O=C(CCN1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)c1ccc2[nH]c(=O)oc2c1 CHEMBL3186509 IC50 1.1 nM
CCCn1cc(-n2c(C)c(Sc3cccc(C(=O)O)c3F)c3ccc(Cl)c(F)c32)cn1 CHEMBL5425421 IC50 1.1 nM
O=C(Nc1ccc(CP(=O)(O)O)cc1)C1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL4217352 IC50 1.23 nM
O=C(NC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)c1ccc(CP(=O)(O)O)cc1 CHEMBL4205127 IC50 1.36 nM
C[C@@H](c1ccc2ccc(O[C@H]3CC[C@@H](C)CC3)c(C(F)(F)F)c2c1)N1C2CCC1CC(C(=O)O)C2 CHEMBL4850429 IC50 1.4 nM
CC(=O)N1CCN(c2ccc(CNc3ccc(OCc4ccc(C(F)F)nc4)nn3)cc2F)CC1 CHEMBL4788435 IC50 1.5 nM
Cc1cccc(C(=O)N[C@@H](C(=O)N2CCC3(CC2)C(=O)N(C)CN3c2ccccc2)C2CCCCC2)c1F CHEMBL4635769 IC50 1.6 nM
CC(=O)N1CCN(c2ccc(CNc3ccc(OCc4ccc(C(F)F)nc4)nn3)cc2)CC1(C)C CHEMBL4745566 IC50 1.6 nM
O=C(Nc1ccc(CP(=O)(O)O)cc1)C1CCN(C(=O)OCc2ccc(OC(F)(F)F)cc2F)CC1 CHEMBL4214731 IC50 1.67 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCC(O)CC4)cc3)cn2c1NC(=O)NCc1ccc(F)cc1 CHEMBL4858390 IC50 1.72 nM
O=C(Nc1nc(CP(=O)(O)O)cs1)C1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL4212398 IC50 1.75 nM
O=C(Nc1ccc(CP(=O)(O)O)cc1)C1CCN(C(=O)OCc2cccc(Cl)c2)CC1 CHEMBL4211269 IC50 1.79 nM
CC(=O)N1CC2CC1CN2c1ccc(CNc2ccc(OCc3ccc(C(F)F)nc3)nn2)cc1 CHEMBL4758133 IC50 1.8 nM
FC(F)c1ccc(COc2ccc(NCc3ccc(N4CCN(C5COC5)CC4)cc3)nn2)cn1 CHEMBL4751395 IC50 1.8 nM
CC(=O)N1CCN(c2ccc(CNc3ccc(OCc4ccc(C(F)F)nc4)nn3)nc2)CC1 CHEMBL4743845 IC50 1.9 nM
CC(=O)N1CCN(c2ccc(CNc3ccc(OCc4ccc(C(F)F)nc4)nn3)c(C(F)(F)F)c2)CC1 CHEMBL4784419 IC50 1.9 nM
O=C(Nc1ccc(CP(=O)(O)O)cc1)C1CCN(C(=O)OCc2ccc(OC(F)(F)F)cc2)CC1 CHEMBL4203076 IC50 1.97 nM
O=C(CCCc1c[nH]nn1)NC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL3827512 IC50 2.0 nM
C[C@H](NC(=O)CCc1nc2cccnc2n1Cc1ccc(C(F)(F)F)cc1)c1ccc(Cl)cc1 CHEMBL3889955 IC50 2.0 nM
C[C@H](NC(=O)CCc1nc2cccnc2n1Cc1ccc(OC(F)F)cc1)c1ccc(Cl)cc1 CHEMBL3946146 IC50 2.0 nM
C[C@H](NC(=O)CSc1nc2cccnc2n1Cc1ccc(OC(F)(F)F)cc1)c1ccc(F)cc1 CHEMBL3917466 IC50 2.0 nM
Cc1c(Sc2cccc(C(=O)[O-])c2F)c2ccc(Cl)c(F)c2n1CC(=O)N1CC2(CC2)c2ccccc21 CHEMBL4102874 IC50 2.0 nM
CCc1nc2ccc(-c3cccnc3)cn2c1N(C)c1nc(-c2ccc(F)cc2)cs1 CHEMBL4100462 IC50 2.0 nM
CNC(=O)CN1CN(c2ccccc2)C2(CCN(C(=O)[C@H](NC(=O)c3cccc(C)c3F)C3CCCCC3)CC2)C1=O CHEMBL4639517 IC50 2.0 nM
Cc1cccc(C(=O)N[C@@H](C(=O)N2CCC3(CC2)C(=O)N(C)CN3c2ccccc2)C(C)C)c1 CHEMBL4633392 IC50 2.0 nM
CC(=O)N1CCN(c2ccc(CNc3ccc(OCc4cncc(C#N)c4)nn3)cc2)CC1 CHEMBL4759980 IC50 2.0 nM
CCn1cc(-n2c(C3CC3)c(Sc3cccc(C(=O)O)c3F)c3ccc(Cl)c(F)c32)cn1 CHEMBL4642052 IC50 2.0 nM
Cc1c(Sc2cccc(C(=O)[O-])c2F)c2ccc(Cl)c(F)c2n1C(=O)N1CC2(CC2)c2ccccc21 CHEMBL5430413 IC50 2.0 nM
CCn1cc(/C(=N/Nc2nc3ccccc3s2)C(F)(F)F)c2cc(-c3nc(CN4CCC(O)CC4)cs3)ccc21 CHEMBL4781471 IC50 2.1 nM
CCn1cc(NC(=O)NCc2ccc(OC)c(Cl)c2)c2cc(-c3nc(CN(CCO)CCO)cs3)ccc21 CHEMBL5170664 IC50 2.17 nM
O=C(NC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)c1nc(-c2ccc(CP(=O)(O)O)cc2)cs1 CHEMBL4092264 IC50 2.19 nM
O=C(NC[C@@H]1[C@H]2CN(C(=O)OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]12)c1ccc2[nH]nnc2c1 CHEMBL4165749 IC50 2.2 nM
O=C(CCCCc1c[nH]nn1)N1CCc2nc(NC3Cc4ccccc4C3)ncc2C1 CHEMBL4453084 IC50 2.2 nM
O=C(COCCc1c[nH]nn1)N1Cc2cnc(NC3Cc4ccccc4C3)nc2C1 CHEMBL4448598 IC50 2.2 nM
CC(C)[C@@H](NC(=O)c1cccc(F)c1)C(=O)N1CCC2(CC1)C(=O)N(C)CN2c1ccccc1 CHEMBL4648587 IC50 2.2 nM
CC(=O)N1CCN(c2ccc(C(C)Nc3ccc(OCc4ccc(C(F)(F)F)nc4)nn3)cc2)CC1 CHEMBL4877694 IC50 2.2 nM
CCn1cc(NC(=O)NCc2ccc(F)cc2)c2cc(NC(=O)c3ccc(CN4CCC(O)CC4)cc3)ccc21 CHEMBL4744849 IC50 2.3 nM
CC(=O)N1CCN(c2ccc(C3(Nc4ccc(OCc5ccc(C(F)(F)F)nc5)nn4)CC3)cc2F)CC1 CHEMBL4855996 IC50 2.4 nM
O=C(CCN1CCc2nc(NC3Cc4ccccc4C3)ncc2C1)c1ccc2[nH]c(=O)oc2c1 CHEMBL4549771 IC50 2.5 nM
CC(=O)N1CCN(c2ccc(C3(Nc4ccc(OCc5ccc(C(F)(F)F)nc5)nn4)CC3)cc2)CC1 CHEMBL4867860 IC50 2.5 nM
O=C(CCc1nc2ccccc2s1)N1CCc2ncnc(Cc3ccc(F)cc3)c2C1 CHEMBL3827088 IC50 2.59 nM
CC(=O)N1CCN(c2ccc([C@H](C)Nc3ccc(OCc4ccc(C(F)(F)F)nc4)nn3)cc2)CC1 CHEMBL4858728 IC50 2.6 nM
CCc1nc2c(C)cc(-c3ccc(C(=O)N4CCN(CCO)CC4)cc3)cn2c1NC(=O)OCc1ccc2c(c1)OCO2 CHEMBL5439867 IC50 2.7 nM
O=C(CCc1ccc2[nH]c(=O)oc2c1)N1CCc2nc(NC3Cc4ccccc4C3)ncc2C1 CHEMBL4476558 IC50 2.8 nM
CS(=O)(=O)Nc1ccc(-c2csc(C(=O)NC3CCN(C(=O)OCc4cc(Cl)cc(Cl)c4)CC3)n2)cc1 CHEMBL4065817 IC50 2.99 nM
COc1ccc(Cn2c(CCC(=O)N[C@@H](C)c3ccc(Cl)cc3)nc3cccnc32)cc1 CHEMBL3944813 IC50 3.0 nM
C[C@H](NC(=O)CCc1nc2ccncc2n1Cc1ccc(OC(F)(F)F)cc1)c1ccc(Cl)cc1 CHEMBL3912114 IC50 3.0 nM
O=C(CCc1c[nH]nn1)NC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL3906229 IC50 3.0 nM
O=C(CCCc1c[nH]nn1)NC1CCN(C(=O)OCc2cc(Br)cc(C(F)(F)F)c2)CC1 CHEMBL3908584 IC50 3.0 nM
COc1ccc(COc2ccc(NCc3ccc(N4CCN(C(C)=O)CC4)cc3)nn2)cn1 CHEMBL4794512 IC50 3.0 nM
CCn1cc(NC(=O)OCc2cccc(Cl)c2Cl)c2cc(-c3nc(CN4CCOCC4)cs3)ccc21 CHEMBL5202031 IC50 3.2 nM
O=C(Nc1ccc(CP(=O)(O)O)cc1)C1CCN(C(=O)OCc2ccccc2Cl)CC1 CHEMBL4216236 IC50 3.29 nM
CC(=O)N1CCN(c2ccc([C@@H](C)Nc3ccc(OCc4ccc(C(F)(F)F)nc4)nn3)cc2)CC1 CHEMBL4867383 IC50 3.4 nM
CC(=O)N1CCN(c2ccc(C3(Nc4ccc(OCc5ccc(C(F)(F)F)nc5)nn4)CC3)cc2C)CC1 CHEMBL4851047 IC50 3.4 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCN(CCO)CC4)cc3)cn2c1NC(=O)OCc1cc(Cl)cc(Cl)c1 CHEMBL5177541 IC50 3.4 nM
O=C(CCCCc1c[nH]nn1)NC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL3890736 IC50 3.5 nM
CNC(=O)CN1CN(c2ccccc2)C2(CCN(C(=O)[C@H](NC(=O)c3cccc(Cl)c3)C3CCCCC3)CC2)C1=O CHEMBL4645846 IC50 3.5 nM
C[C@@H](c1ccc2ccc(O[C@H]3CC[C@@H](C)CC3)c(C(F)(F)F)c2c1)N1C2CCCC1CC(C(=O)O)C2 CHEMBL4872157 IC50 3.6 nM
O=C(NC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)C1)c1nc(CP(=O)(O)O)cs1 CHEMBL4216825 IC50 3.71 nM
C[C@]1(C(=O)O)CC[C@H](CC(=O)N2CCc3c(n(Cc4cnc(C(F)(F)F)s4)c4ncccc34)C2)CC1 CHEMBL3966234 IC50 3.8 nM
O=C(OCc1cc(Cl)cc(Cl)c1)N1CC(N2CCN(C(=O)c3ccc4[nH]c(=O)oc4c3)CC2)C1 CHEMBL4128124 IC50 3.9 nM
N#Cc1cc(COC(=O)N2CCC(NC(=O)CCCc3c[nH]nn3)CC2)cc(C(F)(F)F)c1 CHEMBL3959644 IC50 4.0 nM
O=C(CCCCCc1c[nH]nn1)NC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL3894127 IC50 4.0 nM
Cc1c(Sc2cccc(C(=O)O)n2)c2ccc(Cl)cc2n1-c1cnn(C)c1 CHEMBL3827757 IC50 4.0 nM
O=C(CCc1ccc2[nH]c(=O)oc2c1)N1CCc2nc(NCCc3ccc(Cl)cc3)ncc2C1 CHEMBL4569141 IC50 4.0 nM
CC(=O)N1CCN(c2ccc(CNc3ccc(OCc4cccc(C#N)c4)nn3)cc2)CC1 CHEMBL4760475 IC50 4.0 nM
CC(=O)N1CCN(c2ccc(CNc3ccc(OCc4ccc(OC(F)(F)F)nc4)nn3)cc2)CC1 CHEMBL4796631 IC50 4.0 nM
CC(=O)N1CCC(c2ccc(CNc3ccc(OCc4ccccc4)nn3)cc2)CC1 CHEMBL4792073 IC50 4.0 nM
CCOC(=O)Cn1c(C)cc(=O)n2cc(-c3ccc(Cl)cc3)nc12 CHEMBL4529959 IC50 4.2 nM
NS(=O)(=O)c1cc(-c2csc(C(=O)NC3CCN(C(=O)OCc4cc(Cl)cc(Cl)c4)CC3)n2)ccc1Cl CHEMBL4087949 IC50 4.47 nM
CC(C)(CCCC(=O)N1CCc2c(n(Cc3cnc(C(F)(F)F)s3)c3ncccc23)C1)C(=O)O CHEMBL3918144 IC50 4.5 nM
NS(=O)(=O)Cc1ccc(NC(=O)C2CCN(C(=O)OCc3cc(Cl)cc(Cl)c3)CC2)cc1 CHEMBL4208368 IC50 4.62 nM
O=C(CCCCn1ccnc1)N1CCc2nc(NC3Cc4ccccc4C3)ncc2C1 CHEMBL4454442 IC50 4.8 nM
C[C@@H]1CN(CC(=O)N2CCc3c(n(Cc4ccc(C(F)(F)F)s4)c4ncccc34)C2)C[C@H](C)N1CC(=O)O CHEMBL3933325 IC50 4.9 nM
C[C@H](NC(=O)COc1nc2cccnc2n1Cc1ccc(OC(F)(F)F)cc1)c1ccc(Cl)cc1 CHEMBL3983022 IC50 5.0 nM
O=C(CCc1nc2cccnc2n1Cc1ccc(F)cc1)N[C@@H](CO)c1ccc(Cl)cc1 CHEMBL3926932 IC50 5.0 nM
O=C(C[C@H]1CC[C@H](C(=O)O)CC1)N1CCc2c(n(Cc3ccc(Cl)cc3F)c3ncccc23)C1 CHEMBL3677653 IC50 5.0 nM
Cc1cc(COC(=O)N2CCC(NC(=O)CCCc3c[nH]nn3)CC2)cc(C(F)(F)F)c1 CHEMBL3954222 IC50 5.0 nM
Cc1c(Sc2cccc(C(=O)O)c2)c2ccc(Cl)cc2n1-c1ccccc1 CHEMBL4073215 IC50 5.0 nM
CCOC(=O)N1CCC(NC(=O)c2ccc3nc(CC)c(N(C)c4nc(-c5ccc(Cl)cc5)cs4)n3c2)CC1 CHEMBL4073638 IC50 5.0 nM
O=C(CC12CCC(C(=O)O)(CC1)C2)N1CCc2c(n(Cc3cnc(C(F)(F)F)s3)c3ncccc23)C1 CHEMBL3889650 IC50 5.1 nM
CN1C(=O)N(Cc2ccc(F)cc2)C(=O)/C1=C\c1ccc(OCc2ccc(B(O)O)cc2)cc1 CHEMBL1802517 IC50 5.3 nM
COc1cc(CC(=O)N2CCc3c(n(Cc4ccc(OC(F)(F)F)cc4)c4ncccc34)C2)ccc1C(=O)O CHEMBL3987170 IC50 5.4 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCN(CCO)CC4)cc3)cn2c1NC(=O)NCc1ccc(OC)c(Cl)c1 CHEMBL4879002 IC50 5.43 nM
O=C(CC12CCC(C(=O)O)(CC1)C2)N1CCc2c(n(Cc3ccc(F)cc3)c3ncccc23)C1 CHEMBL4649390 IC50 5.5 nM
O=C1S/C(=C\c2ccc(OCc3ccc(B(O)O)cc3)cc2)C(=O)N1Cc1ccc(F)cc1 CHEMBL1173671 IC50 5.67 nM
CCn1cc(NC(=O)OCc2ccc(F)c(F)c2)c2cc(-c3nc(CN4CCN(CCO)CC4)cs3)ccc21 CHEMBL5170351 IC50 5.7 nM
Cc1nnn(Cc2cc(C(F)(F)F)ccc2/C=C/C(=O)N2CCC(c3noc(C)n3)CC2)n1 CHEMBL4780722 IC50 5.8 nM
COc1ccc(CN2CCN(C(=O)/C=C/c3ccc(Cl)cc3Cn3nnc(C)n3)CC2)nc1 CHEMBL4779944 IC50 5.9 nM
Cc1cnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)n1 CHEMBL4786202 IC50 5.9 nM
C[C@H](NC(=O)CCc1nc2cccnc2n1Cc1ccc(F)cc1)c1ccc(F)cc1 CHEMBL3916898 IC50 6.0 nM
Cc1cc(C)cc(COC(=O)N2CCC(NC(=O)CCCc3c[nH]nn3)CC2)c1 CHEMBL3907952 IC50 6.0 nM
C[C@H](CCC(=O)N[C@@H]1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)C1)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL4062929 Ki 6.0 nM
CC(=O)N1CCN(c2ccc(CNc3ccc(OCc4cc(Cl)cc(Cl)c4)nn3)cc2)CC1 CHEMBL4746361 IC50 6.0 nM
CCCCCCCCCCCCCC(=O)Nc1ccc(C(F)P(=O)(O)O)cc1 CHEMBL1818146 Ki 6.1 nM
O=C(CC12CCC(C(=O)O)(CC1)CC2)N1CCc2c(n(Cc3ccc(F)cc3)c3ncccc23)C1 CHEMBL4647102 IC50 6.1 nM
CN1C(=O)N(Cc2ccc(F)cc2)C(=O)/C1=C/c1ccc(OCc2ccc(B(O)O)cc2)cc1 CHEMBL1802518 IC50 6.7 nM
CC(C)(CCCC(=O)N1CCc2c(n(Cc3ccc(F)cc3F)c3ncccc23)C1)C(=O)O CHEMBL3677651 IC50 6.7 nM
O=C(c1cc(-c2cnn[nH]2)ccn1)N1CCc2nc(NC3Cc4ccccc4C3)ncc2C1 CHEMBL3827513 IC50 7.0 nM
O=C(CCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)NCc1c[nH]nn1 CHEMBL3970689 IC50 7.0 nM
CCc1nc2ccc(N3CCN(CC(=O)N4CCC(CF)C4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)c(C#N)s1 CHEMBL5093347 Ki 7.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCN(CCO)CC4)cc3)cn2c1NC(=O)OCc1ccc(F)cc1 CHEMBL5195787 IC50 7.1 nM
O=C(Nc1ccc(CP(=O)(O)O)cc1)C1CCN(C(=O)OCc2ccccc2F)CC1 CHEMBL4206899 IC50 7.13 nM
O=C(Nc1ccc(CP(=O)(O)O)cc1)C1CCN(C(=O)OCc2ccccc2)CC1 CHEMBL4209155 IC50 7.17 nM
O=C1C/C(=C\c2ccc(OCc3ccc(B(O)O)cc3)cc2)C(=O)N1Cc1ccc(F)cc1 CHEMBL1802519 IC50 7.3 nM
O=C(C[C@H]1CC[C@H](C(=O)O)CC1)N1CCc2c(n(Cc3ccc(F)cc3F)c3ncccc23)C1 CHEMBL3940971 IC50 7.3 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCC(O)CC4)cc3)cn2c1NC(=O)NCc1ccc(OC)c(Cl)c1 CHEMBL4878631 IC50 7.41 nM
CCn1cc(NC(=O)OCc2ccc(F)c(F)c2)c2cc(-c3nc(CN4CCOCC4)cs3)ccc21 CHEMBL5197507 IC50 7.6 nM
N#Cc1cc(Cl)cc(COC(=O)N2CCC(NC(=O)CCCc3c[nH]nn3)CC2)c1 CHEMBL3958589 IC50 7.7 nM
Cc1cc(CC(=O)N2CCc3c(n(Cc4csc(Cl)c4)c4ncccc34)C2)ccc1C(=O)O CHEMBL3677661 IC50 7.8 nM
O=C(CC12CCC(C(=O)O)(CC1)C2)N1CCc2c(n(Cc3ccc(F)cc3F)c3ncccc23)C1 CHEMBL4634704 IC50 7.9 nM
Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCC(Cc3ncc(C)o3)CC2)n1 CHEMBL4794205 IC50 7.9 nM
C[C@H](NC(=O)CCc1nc2ccncc2n1Cc1ccc(OC(F)(F)F)cc1)c1ccc(F)cc1 CHEMBL3982059 IC50 8.0 nM
Cc1nc(C(F)(F)F)sc1Cn1c2c(c3cccnc31)CCN(C(=O)C[C@H]1CC[C@@](C)(C(=O)O)C1(C)C)C2 CHEMBL3897498 IC50 8.0 nM
N#Cc1cc(Cl)cc(COC(=O)N2CCC(NC(=O)CCCCc3c[nH]nn3)CC2)c1 CHEMBL3954335 IC50 8.0 nM
CCc1nc2ccc(N3CCOCC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)cs1 CHEMBL4084005 IC50 8.0 nM
O=C(NCC1(O)CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)c1ccc2[nH]c(=O)oc2c1 CHEMBL4129507 IC50 8.0 nM
Cc1nnn(Cc2cc(C(F)(F)F)ccc2/C=C/C(=O)N2CCC(c3nnc(C)o3)CC2)n1 CHEMBL4794562 IC50 8.0 nM
COc1cc(COc2ccc(NCc3ccc(N4CCN(C(C)=O)CC4)cc3)nn2)ccn1 CHEMBL4784550 IC50 8.0 nM
CCCCCCCCCCCCCC(=O)Nc1ccc(C(Br)P(=O)(O)O)cc1 CHEMBL1818147 Ki 8.1 nM
O=C(CC12CCC(C(=O)O)(CC1)CC2)N1CCc2c(n(Cc3ccc(F)cc3F)c3ncccc23)C1 CHEMBL4634102 IC50 8.1 nM
C[C@H]1CC[C@@H](Oc2ccc3ccc(CN4C5CCCC4CC(C(=O)O)C5)cc3c2C(F)(F)F)CC1 CHEMBL4871067 IC50 8.2 nM
O=C1S/C(=C\c2ccc(NCc3ccc(B(O)O)cc3)cc2)C(=O)N1Cc1ccc(F)cc1 CHEMBL1802471 IC50 8.3 nM
COc1cc(CC(=O)N2CCc3c(n(Cc4sc(C(F)(F)F)nc4C)c4ncccc34)C2)cc(OC)c1C(=O)O CHEMBL3958484 IC50 8.4 nM
O=C(O)Cc1ccc(NC(=O)C2CCN(C(=O)OCc3cc(Cl)cc(Cl)c3)CC2)cc1 CHEMBL4204027 IC50 8.44 nM
NS(=O)(=O)Nc1ccc(NC(=O)C2CCN(C(=O)OCc3cc(Cl)cc(Cl)c3)CC2)cc1 CHEMBL4203499 IC50 8.9 nM
CCCCCCCCCCCCCC(=O)Nc1ccc(CP(=O)(O)O)cc1 CHEMBL1818144 Ki 9.0 nM
O=C(Nc1cc(F)c(F)c(F)c1)c1cc(S(=O)(=O)N2CCOCC2)c(Cl)cc1Cl CHEMBL4085965 IC50 9.0 nM
CCOC(=O)N1CCC(NCc2ccc3nc(CC)c(N(C)c4nc(-c5ccc(Cl)cc5)cs4)n3c2)CC1 CHEMBL4062291 IC50 9.0 nM
CCc1nc2c(C)cc(-c3ccc(C(=O)N4CCC(O)CC4)cc3)cn2c1NC(=O)NCc1ccc(F)cc1 CHEMBL4869326 IC50 9.17 nM
COc1ccc(CN2CCN(C(=O)/C=C/c3ccc(Cl)cc3Cn3nnc(C)n3)CC2)cc1 CHEMBL4794343 IC50 9.2 nM
Cc1noc(C2CCN(C(=O)/C=C/c3ccc(C(F)(F)F)cc3Cn3nnc(C)n3)CC2)n1 CHEMBL4751607 IC50 9.5 nM
CC(C)(CCCC(=O)N1CCc2c(n(Cc3ccc(Cl)s3)c3ncccc23)C1)C(=O)O CHEMBL3677650 IC50 9.6 nM
Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)n1 CHEMBL4790845 IC50 9.6 nM
O=C(Nc1ccc(/C=C2\SC(=O)N(Cc3ccc(F)cc3)C2=O)cc1)c1ccc(B(O)O)cc1 CHEMBL1802470 IC50 10.0 nM
C[C@H](NC(=O)NCc1nc2cccnc2n1Cc1ccc(F)cc1)c1ccc(Cl)cc1 CHEMBL3907343 IC50 10.0 nM
C[C@H](NC(=O)C[S+]([O-])c1nc2cccnc2n1Cc1ccc(OC(F)(F)F)cc1)c1ccc(F)cc1 CHEMBL3964183 IC50 10.0 nM
CC1(C)[C@@H](CC(=O)N2CCc3c(n(Cc4ccc(C(F)(F)F)cc4)c4ncccc34)C2)CC[C@@]1(C)C(=O)O CHEMBL3926737 IC50 10.0 nM
Cc1cc(Cl)cc(COC(=O)N2CCC(NC(=O)CCCc3c[nH]nn3)CC2)c1 CHEMBL3916809 IC50 10.0 nM
CC(C)(C)[C@H]1CC[C@H](Oc2cccc(-c3cc(F)cc(CNCCC(=O)O)c3)c2)CC1 CHEMBL4063386 IC50 10.0 nM
O=C(NCCC1CN(C(=O)OCc2cc(Cl)cc(Cl)c2)CCO1)c1ccc2[nH]c(=O)oc2c1 CHEMBL4126051 IC50 10.0 nM
O=C(CCCCc1c[nH]cn1)N1CCc2nc(NC3Cc4ccccc4C3)ncc2C1 CHEMBL4462537 IC50 10.0 nM
O=C(OCc1ccccc1)N1CCC(Nc2nc(-c3ccc(CP(=O)(O)O)cc3)cs2)C1 CHEMBL4064505 IC50 10.3 nM
CCn1cc(NC(=O)NCc2ccc(OC)c(Cl)c2)c2cc(-c3nc(CN4CCC(O)CC4)cs3)ccc21 CHEMBL5182319 IC50 10.7 nM
COc1ccc(CNC(=O)Nc2c(C)nc3c(C)cc(-c4ccc(CN5CCC(O)CC5)cc4)cn23)cc1Cl CHEMBL4854624 IC50 10.97 nM
O=C(CC12CCC(C(=O)O)(CC1)CC2)N1CCc2c(n(Cc3cccc(F)c3)c3ncccc23)C1 CHEMBL3677654 IC50 11.0 nM
O=C(CC12CCC(C(=O)O)(CC1)CC2)N1CCc2c(n(Cc3ccc(Cl)cc3)c3ncccc23)C1 CHEMBL3677655 IC50 11.0 nM
Cc1c(Sc2cccc(C(=O)O)c2)c2ccc(Cl)cc2n1-c1cnn(C)c1 CHEMBL4093897 IC50 11.0 nM
CCc1nc2c(C)cc(-c3ccc(C(=O)N4CCC(O)CC4)cc3)cn2c1NC(=O)NCc1ccc(OC)c(Cl)c1 CHEMBL4853577 IC50 11.7 nM
O=C1S/C(=C\c2cccc(OCc3cccc(B(O)O)c3)c2)C(=O)N1Cc1ccc(F)cc1 CHEMBL1173403 IC50 11.9 nM
O=C(CCCC1(C(=O)O)CC1)N1CCc2c(n(Cc3ccc(C(F)(F)F)s3)c3ncccc23)C1 CHEMBL3905272 IC50 12.0 nM
O=C(CCCc1c[nH]nn1)NC1CN(C(=O)OCc2cc(Cl)cc(Cl)c2)C1 CHEMBL3929207 IC50 12.0 nM
CCc1nc2ccc(N3CCN(CCO)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)cs1 CHEMBL4091774 IC50 12.0 nM
CC1(C)[C@@H](CC(=O)N2CCc3c(n(Cc4ccc(F)c(Cl)c4)c4ncccc34)C2)CC[C@@]1(C)C(=O)O CHEMBL3677656 IC50 13.0 nM
O=C1N=C(N2CCN(Cc3cccc(B(O)O)c3)CC2)S/C1=C\c1ccc(Cl)c(Cl)c1 CHEMBL4540122 IC50 13.0 nM
Cc1nnn(Cc2cc(C(F)(F)F)ccc2/C=C/C(=O)N2CCC(C(F)(F)F)CC2)n1 CHEMBL4795515 IC50 13.0 nM
CCc1nc2ccc(N3CCN(CC(=O)N4CCN(CCF)CC4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)c(C#N)s1 CHEMBL5085520 Ki 13.0 nM
CCn1cc(NC(=O)NCc2ccc(Cl)cc2)c2cc(NC(=O)c3ccc(CN4CCC(O)CC4)cc3)ccc21 CHEMBL4787006 IC50 13.1 nM
CC(C)[C@@H](NC(=O)c1cc(C(F)(F)F)ccc1F)C(=O)N1CCC2(CC1)C(=O)N(C)CN2c1ccc2[nH]ncc2c1 CHEMBL4640236 IC50 13.4 nM
O=C(NC1CCN(C(=O)OCc2ccccc2)CC1)c1nc(-c2ccc(CP(=O)(O)O)cc2)cs1 CHEMBL4099035 IC50 13.67 nM
COc1ccc(C(CCO)Nc2ccc(C(=O)NCc3cc(F)ccc3F)nn2)cc1 CHEMBL3897178 IC50 14.0 nM
CC(C)[C@@H](NC(=O)c1cc(C(F)(F)F)ccc1F)C(=O)N1CCC2(CC1)C(=O)N(C)C(=O)N2c1ccc2[nH]ncc2c1 CHEMBL4636208 IC50 14.0 nM
CCc1nc2ccc(N3CCN(CC(=O)N4CC[C@@H](F)C4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)c(C#N)s1 CHEMBL5091502 Ki 14.0 nM
CCc1nc2ccc(N3CCN(CC(=O)N4CC(CF)C4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)c(C#N)s1 CHEMBL5084424 Ki 14.0 nM
CCn1cc(NC(=O)NCc2ccc(OC)c(Cl)c2)c2cc(-c3nc(CN4CCC[C@H]4CO)cs3)ccc21 CHEMBL5191789 IC50 14.3 nM
O=C(CC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)NCCc1c[nH]nn1 CHEMBL3899533 IC50 15.0 nM
CCc1nc2ccc(N3CCN(CC(=O)N4CCC(F)C4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)c(C#N)s1 CHEMBL5084058 Ki 15.0 nM
CCc1nc2ccc(N3CCN(CC(=O)N4CCC(F)CC4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)c(C#N)s1 CHEMBL5076928 Ki 15.0 nM
CCc1nc2ccc(N3CCN(CC(=O)N4CCCC(F)C4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)c(C#N)s1 CHEMBL5088520 Ki 15.0 nM
CCn1cc(NC(=O)OCc2cccc(Cl)c2Cl)c2cc(-c3nc(CN4CCC[C@H]4CO)cs3)ccc21 CHEMBL4637219 IC50 15.1 nM
O=C(N/N=C/c1ccc(Cl)cc1)N1CCc2ncnc(Nc3cccc(C(F)(F)F)c3)c2C1 CHEMBL4745233 IC50 15.3 nM
CCn1cc(C(=O)N/N=C(\C)c2ccc(F)cc2)c2cc(-c3nc(CN4CCC[C@H]4CO)cs3)ccc21 CHEMBL4644036 IC50 15.7 nM
O=C(O)CCCC(=O)N1CCc2c(n(CCCc3ccccc3)c3ncccc23)C1 CHEMBL3677649 IC50 16.0 nM
O=C(O)C1=CCN(CC(=O)N2CCc3c(n(Cc4ccc(C(F)(F)F)s4)c4ncccc34)C2)CC1 CHEMBL3967509 IC50 16.0 nM
O=C(C[C@H]1CC[C@@H](C(=O)O)CC1)N1CCc2c(n(Cc3ccc(F)cc3F)c3ncccc23)C1 CHEMBL4634540 IC50 16.0 nM
Cc1ncn(C2CCN(C(=O)/C=C/c3ccc(C(F)(F)F)cc3Cn3nnc(C)n3)CC2)n1 CHEMBL4761729 IC50 16.0 nM
C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1Cn1ncnn1 CHEMBL4781284 IC50 16.0 nM
COc1ccc(Cn2c(CCC(=O)N[C@@H](C)c3ccccc3)nc3cccnc32)cc1 CHEMBL3907905 IC50 17.0 nM
C[C@]1(C(=O)O)CC[C@H](CC(=O)N2CCc3c(n(Cc4ccc(C(F)(F)F)s4)c4ncccc34)C2)CC1 CHEMBL3898350 IC50 17.0 nM
O=C(CCc1cnn[nH]1)NCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL3986548 IC50 17.0 nM
CC(C)(CCCC(=O)N1CCc2c(n(Cc3cccc(F)c3)c3ncccc23)C1)C(=O)O CHEMBL4634784 IC50 17.0 nM
O=C(C[C@H]1CC[C@H](C(=O)O)CC1)N1CCc2c(n(Cc3cccc(F)c3)c3ncccc23)C1 CHEMBL4642470 IC50 17.0 nM
CCc1nc2ccc(N3CCN(CC(=O)N4CC(OCCF)C4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)c(C#N)s1 CHEMBL5088371 Ki 17.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCC(O)CC4)cc3)cn2c1NC(=O)OCc1cc(Cl)cc(Cl)c1 CHEMBL5189914 IC50 17.0 nM
CCn1cc(NC(=O)OCc2ccccc2)c2cc(-c3nc(CN4CCN(CCO)CC4)cs3)ccc21 CHEMBL5202002 IC50 17.3 nM
CCn1cc(NC(=O)NCc2ccccc2)c2cc(-c3nc(CN4CCC[C@H]4CO)cs3)ccc21 CHEMBL5201741 IC50 17.6 nM
CCCCCCCCCC(=O)Nc1ccc(CP(=O)(O)O)cc1 CHEMBL1818148 Ki 18.0 nM
O=C(CCCc1cnn[nH]1)NCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL3943568 IC50 18.0 nM
O=C(Nc1cc(F)c(F)c(F)c1Br)c1cc(S(=O)(=O)N2CCOCC2)c(Cl)cc1Cl CHEMBL4079588 IC50 18.0 nM
O=C(OCc1cc(Cl)cc(Cl)c1)N1CCC(N2CCN(C(=O)c3ccc4[nH]c(=O)oc4c3)CC2)C1 CHEMBL4127145 IC50 18.0 nM
Cc1noc(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)n1 CHEMBL4790906 IC50 18.0 nM
O=C(NO)c1ccc(NC(=O)C2CCN(C(=O)OCc3cc(Cl)cc(Cl)c3)CC2)cc1 CHEMBL4215710 IC50 18.72 nM
Cc1nnn(Cc2cc(Cl)ccc2CCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)n1 CHEMBL4748162 IC50 19.0 nM
Cc1[nH]c2cc(F)c(N3CCN(CCN(C)C)CC3)cc2c1/C(=N/Nc1nc(-c2ccc(F)cc2)c(C#N)s1)C(F)(F)F CHEMBL4797813 IC50 19.0 nM
[2H]C([2H])(F)C([2H])([2H])N1CCN(C(=O)CN2CCN(c3ccc4nc(CC)c(N(C)c5nc(-c6ccc(F)cc6)c(C#N)s5)n4c3)CC2)CC1 CHEMBL5094730 Ki 19.0 nM
CC(C)Oc1ccc(Nc2ncc3c(n2)CCN(C(=O)CCc2ccc4[nH]c(=O)oc4c2)C3)cc1 CHEMBL4472840 IC50 19.8 nM
Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)CC2)n1 CHEMBL4783839 IC50 20.0 nM
O=C(CCCc1c[nH]nn1)NC1CCN(C(=O)/C=C/c2cc(Cl)cc(Cl)c2)CC1 CHEMBL3950696 IC50 21.0 nM
CS(=O)(=O)c1ccc(/C=N/NC(=O)N2CCc3ncnc(Nc4ccc(F)c(Cl)c4)c3C2)cc1 CHEMBL4744073 IC50 21.0 nM
O=C(Nc1ccc(Br)cc1)c1cc(S(=O)(=O)N2CCCCC2)c(Cl)cc1Cl CHEMBL5414051 IC50 21.0 nM
CCn1cc(NC(=O)NCc2ccc(F)cc2)c2cc(-c3nc(CN4CCN(C)CC4)cs3)ccc21 CHEMBL5170405 IC50 21.1 nM
CCn1cc(NC(=O)OCc2cc(Cl)cc(Cl)c2)c2cc(-c3nc(CN(CCO)CCO)cs3)ccc21 CHEMBL4641011 IC50 21.3 nM
CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)C[C@H](Br)P(=O)(O)O CHEMBL3621356 IC50 22.0 nM
C[C@]1(C(=O)O)CC[C@H](CC(=O)N2CCc3c(n(Cc4ccc(F)cc4F)c4ncccc34)C2)CC1 CHEMBL4643803 IC50 22.0 nM
CCn1cc(NC(=O)NCc2ccc(F)cc2)c2cc(-c3nc(CN4CCC[C@H]4CO)cs3)ccc21 CHEMBL5194154 IC50 23.1 nM
CCCCCCCCCCCCCC(=O)Nc1ccc(C(O)P(=O)(O)O)cc1 CHEMBL1818145 Ki 24.0 nM
O=C(CCCc1c[nH]nn1)NC1CCN(C(=O)OCCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL3971191 IC50 24.0 nM
O=C(CCCCc1nn[nH]n1)N1CCc2nc(NC3Cc4ccccc4C3)ncc2C1 CHEMBL4446322 IC50 24.0 nM
CC(C)(CCC(=O)N1CCc2c(n(Cc3cccc(F)c3)c3ncccc23)C1)CC(=O)O CHEMBL4649090 IC50 24.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCC(C)CC4)cc3)cn2c1NC(=O)OCc1cc(Cl)cc(Cl)c1 CHEMBL5171446 IC50 24.0 nM
CCCCCCCCCC(=O)Nc1ccc(C(O)P(=O)(O)O)cc1 CHEMBL1818149 Ki 24.2 nM
O=C(N/N=C/c1ccc(Cl)cc1)N1CCc2ncnc(Nc3ccc(F)c(Cl)c3)c2C1 CHEMBL4758991 IC50 24.2 nM
COc1ccc(C(CCO)Nc2ccc(C(=O)NCc3cc(F)cc(F)c3)nn2)cc1 CHEMBL3971846 IC50 24.9 nM
O=C1SC(Cc2ccc(OCc3ccc(B(O)O)cc3)cc2)C(=O)N1Cc1ccc(F)cc1 CHEMBL1802473 IC50 25.0 nM
C[C@]1(C(=O)O)CC[C@H](CC(=O)N2CCc3c(n(Cc4ccc(Cl)cc4)c4ncccc34)C2)CC1 CHEMBL3677660 IC50 25.0 nM
Cc1[nH]c2cc(Cl)ccc2c1Sc1cccc(C(=O)O)n1 CHEMBL4073328 IC50 25.0 nM
Cc1ccc2c(Sc3cccc(C(=O)O)n3)c(C)n(-c3cnn(C)c3)c2c1 CHEMBL4086837 IC50 25.0 nM
CN(CCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)C(=O)c1c[nH]c(=O)o1 CHEMBL3931791 IC50 25.0 nM
O=C1N=C(N2CCN(Cc3ccc(C(=O)O)cc3)CC2)S/C1=C\c1ccc(Cl)c(Cl)c1 CHEMBL5286227 IC50 25.0 nM
CCn1cc(NC(=O)O[C@H](C)c2ccccc2Cl)c2cc(-c3nc(CN4CCOCC4)cs3)ccc21 CHEMBL5184482 IC50 25.1 nM
O=C1N/C(=C\c2ccc(OCc3ccc(B(O)O)cc3)cc2)C(=O)N1Cc1ccc(F)cc1 CHEMBL1802516 IC50 26.0 nM
C[C@]1(C(=O)O)CC[C@H](CC(=O)N2CCc3c(n(Cc4ccc(F)cc4)c4ncccc34)C2)CC1 CHEMBL3677659 IC50 26.0 nM
N#Cc1cc(Cl)cc(COC(=O)N2CCC(NC(=O)CCc3c[nH]nn3)CC2)c1 CHEMBL3982999 IC50 26.0 nM
CCc1nc2ccc(N3CCN(CC(=O)N4CC(O)C4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)c(C#N)s1 CHEMBL4084282 IC50 26.0 nM
Cc1cc(CN2CCN(C(=O)/C=C/c3ccc(Cl)cc3Cn3nnc(C)n3)CC2=O)on1 CHEMBL4747057 IC50 26.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCC[C@H]4CO)cc3)cn2c1NC(=O)OCc1ccc(F)cc1 CHEMBL5189398 IC50 26.4 nM
O=C(N/N=C/c1ccc(F)cc1Cl)N1CCc2ncnc(Nc3cccc(C(F)(F)F)c3)c2C1 CHEMBL4780302 IC50 26.9 nM
CCc1nc2ccc(C3CCN(CC(=O)N4CC(O)C4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)c(C#N)s1 CHEMBL4061747 IC50 27.0 nM
O=C(N/N=C/c1ccc(Cl)cc1)N1CCc2ncnc(Nc3cccc(Br)c3)c2C1 CHEMBL4787461 IC50 27.5 nM
O=C(O)C1CCN(CC(=O)N2CCc3c(n(Cc4ccc(OC(F)(F)F)cc4)c4ncccc34)C2)CC1 CHEMBL3982922 IC50 28.0 nM
O=C(Cc1c[nH]nn1)NCCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL3895225 IC50 28.0 nM
O=C(O)c1ccc(CC(=O)N2CCc3c(n(Cc4cccc(F)c4)c4ncccc34)C2)cc1 CHEMBL4645794 IC50 28.0 nM
O=C(NCCCP(=O)(O)O)c1ccc2c(C(F)(F)F)c(O[C@H]3CC[C@@H](C(F)(F)F)CC3)ccc2c1 CHEMBL4858196 IC50 28.0 nM
COc1cc(/C=C2\SC(=O)N(Cc3ccc(F)cc3)C2=O)ccc1OCc1ccc(B(O)O)cc1 CHEMBL5267660 IC50 28.0 nM
O=C1S/C(=C\c2ccc(OCc3cccc(B(O)O)c3)cc2)C(=O)N1Cc1ccc(F)cc1 CHEMBL1173670 IC50 28.0 nM
O=C(CCc1nc2cccnc2n1Cc1ccccc1)NCc1ccc(Cl)cc1 CHEMBL3953575 IC50 29.0 nM
CN(CCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)C(=O)c1c[nH]c(=O)s1 CHEMBL3917042 IC50 29.0 nM
O=C(C[C@H]1CC[C@@H](C(=O)O)CC1)N1CCc2c(n(Cc3cccc(F)c3)c3ncccc23)C1 CHEMBL4639112 IC50 29.0 nM
O=C(N/N=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCc2ncnc(Nc3cccc(Br)c3)c2C1 CHEMBL4787187 IC50 29.1 nM
Cc1ccc(/C=N/NC(=O)N2CCc3ncnc(Nc4cccc(C(F)(F)F)c4)c3C2)cc1 CHEMBL4227281 IC50 29.1 nM
O=C1S/C(=C\c2cccc(OCc3ccc(B(O)O)cc3)c2)C(=O)N1Cc1ccc(F)cc1 CHEMBL1173627 IC50 29.6 nM
CCCCCCn1c(C)cc(=O)n2cc(-c3ccc(Cl)cc3)nc12 CHEMBL4466454 IC50 30.0 nM
Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCN(Cc3coc(C)n3)CC2)n1 CHEMBL4764982 IC50 30.0 nM
CCn1cc(NC(=O)NCc2ccc(Cl)cc2)c2cc(-c3nc(CN(CCO)CCO)cs3)ccc21 CHEMBL5199962 IC50 30.0 nM
O=C(N/N=C/c1cccc(C(F)(F)F)c1)N1CCc2ncnc(Nc3cccc(Br)c3)c2C1 CHEMBL4750860 IC50 30.2 nM
COc1ccc(-c2csc(C(=O)NC3CCN(C(=O)OCc4cc(Cl)cc(Cl)c4)CC3)n2)cc1 CHEMBL4083514 IC50 30.25 nM
CCn1cc(NC(=O)OCc2ccc3c(c2)OCO3)c2cc(-c3nc(CN(CCO)CCO)cs3)ccc21 CHEMBL4639039 IC50 30.7 nM
Cc1c(Sc2cccc(C(=O)O)n2)c2ccc(Cl)cc2n1C CHEMBL4090230 IC50 31.0 nM
CC(C)[C@@H](NC(=O)c1cc(C(F)(F)F)ccc1F)C(=O)N1CCC2(CC1)C(=O)N(C)C(=O)N2c1ccc(C(=O)O)cc1 CHEMBL4649125 IC50 31.0 nM
O=C(N/N=C/c1ccc(O)c(Br)c1)N1CCc2ncnc(Nc3ccc(F)c(Cl)c3)c2C1 CHEMBL4748324 IC50 31.3 nM
O=C(Nc1cccc(F)c1)c1cc(S(=O)(=O)N2CCOCC2)c(Cl)cc1Cl CHEMBL3828733 IC50 31.4 nM
CCn1cc(NC(=O)OCc2ccc3c(c2)OCO3)c2cc(-c3nc(CN4CCOCC4)cs3)ccc21 CHEMBL5174164 IC50 31.7 nM
O=C(Nc1ccc(F)c(F)c1)c1cc(S(=O)(=O)N2CCOCC2)c(Cl)cc1Cl CHEMBL4096134 IC50 32.0 nM
CCc1nc2ccc(N3CCN(CC(=O)N4CC[C@H](F)C4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)c(C#N)s1 CHEMBL5078471 Ki 32.0 nM
CCn1cc(NC(=O)NCc2ccc(Cl)cc2)c2cc(-c3nc(CN4CCOCC4)cs3)ccc21 CHEMBL5200511 IC50 32.1 nM
Cc1c(Cc2cccc(C(=O)O)c2)c2ccc(Cl)cc2n1-c1cnn(C)c1 CHEMBL4078251 IC50 33.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCOCC4)cc3)cn2c1NC(=O)OCc1ccc(OC)c(Cl)c1 CHEMBL5171136 IC50 33.5 nM
O=C(N/N=C/c1ccc(Cl)cc1Cl)N1CCc2ncnc(Nc3cccc(C(F)(F)F)c3)c2C1 CHEMBL4753611 IC50 33.9 nM
O=C(O)CCCCC(=O)N1CCc2c(n(CCCc3ccccc3)c3ccccc23)C1 CHEMBL3677647 IC50 34.0 nM
CN1C(=O)N(c2ccc3[nH]ncc3c2)C2(CCN(C(=O)[C@H](NC(=O)c3cc(C(F)(F)F)ccc3F)C3CCCC3)CC2)C1=O CHEMBL4644570 IC50 34.0 nM
Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCN(Cc3cnn(C)c3)CC2)n1 CHEMBL4793854 IC50 34.0 nM
CCc1nc2c(C)cc(-c3ccc(CNCCO)cc3)cn2c1NC(=O)OCc1cc(Cl)cc(Cl)c1 CHEMBL5174427 IC50 34.0 nM
CCn1cc(NC(=O)OCc2ccc3c(c2)OCO3)c2cc(-c3nc(CN4CCC(O)CC4)cs3)ccc21 CHEMBL4643433 IC50 34.1 nM
CCn1cc(NC(=O)NCc2ccccc2)c2cc(-c3nc(CN4CCN(C)CC4)cs3)ccc21 CHEMBL5203510 IC50 34.2 nM
CCn1cc(NC(=O)OCc2ccc3c(c2)OCO3)c2cc(-c3nc(CN4CCC[C@H]4CO)cs3)ccc21 CHEMBL4633587 IC50 34.7 nM
CS(=O)(=O)c1ccc(/C=N/NC(=O)N2CCc3ncnc(Nc4cccc(Br)c4)c3C2)cc1 CHEMBL4797812 IC50 34.7 nM
C[C@@H]1CN(CC(=O)N2CCc3c(n(Cc4ccc(Cl)s4)c4ccccc34)C2)C[C@H](C)N1CC(=O)O CHEMBL3677658 IC50 35.0 nM
O=S(=O)(c1cc(C(=S)Nc2cc(F)c(F)c(F)c2)c(Cl)cc1Cl)N1CCOCC1 CHEMBL4094366 IC50 35.0 nM
CCn1cc(NC(=O)OCc2cc(Cl)cc(Cl)c2)c2cc(-c3nc(CN4CCCC4)cs3)ccc21 CHEMBL5200277 IC50 35.1 nM
O=C(N/N=C/c1cccc(Br)c1)N1CCc2ncnc(Nc3cccc(C(F)(F)F)c3)c2C1 CHEMBL4788920 IC50 35.3 nM
CS(=O)(=O)c1ccc(/C=N/NC(=O)N2CCc3ncnc(Nc4cccc(C(F)(F)F)c4)c3C2)cc1 CHEMBL4746928 IC50 35.8 nM
CCn1cc(NC(=O)O[C@H](C)c2ccc(C)cc2)c2cc(-c3nc(CN4CCC[C@H]4CO)cs3)ccc21 CHEMBL4643937 IC50 36.9 nM
Cc1noc(NC(=O)c2ccc(NC(CO)Cc3ccc(Cl)cc3)nn2)c1C CHEMBL3985977 IC50 37.6 nM
Cc1ccc(N2C(=O)N(C)C(=O)C23CCN(C(=O)[C@H](NC(=O)c2cc(C(F)(F)F)ccc2F)C(C)C)CC3)cc1 CHEMBL4642547 IC50 38.0 nM
C[C@H]1CC[C@@H](Oc2ccc3cc(CN4C5CCCC4CC(C(=O)O)C5)ccc3c2C(F)(F)F)CC1 CHEMBL4868783 IC50 38.0 nM
C[C@H](NC(=O)COc1nc2cccnc2n1Cc1ccc(F)cc1)c1ccc(F)cc1 CHEMBL3954360 IC50 39.0 nM
O=C(CCCc1c[nH]nn1)NC1CCN(C(=O)OCc2ccc(C(F)(F)F)cc2)CC1 CHEMBL3902501 IC50 39.0 nM
COc1ccc(CNC(=O)CCc2nc3cccnc3n2Cc2ccccc2)cc1 CHEMBL1889181 IC50 40.0 nM
O=C(Nc1cc(Cl)c(F)c(Cl)c1)c1cc(S(=O)(=O)N2CCOCC2)c(Cl)cc1Cl CHEMBL4060128 IC50 40.0 nM
CCc1nc2ccc(N3CCN(CC(=O)N4CC(F)C4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)c(C#N)s1 CHEMBL5088215 Ki 41.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCC[C@H]4CO)cc3)cn2c1NC(=O)OCc1cc(Cl)cc(Cl)c1 CHEMBL5194357 IC50 41.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCN(CCO)CC4)cc3)cn2c1NC(=O)OCc1ccc(F)c(F)c1 CHEMBL5204000 IC50 41.0 nM
O=C(N/N=C/c1ccc(OC(F)(F)F)cc1)N1CCc2ncnc(Nc3cccc(C(F)(F)F)c3)c2C1 CHEMBL4745544 IC50 41.2 nM
O=C(NC1CCN(C(=O)CCCCc2c[nH]nn2)CC1)OCc1cc(Cl)cc(Cl)c1 CHEMBL3930492 IC50 42.0 nM
O=C(N/N=C/c1cc([N+](=O)[O-])ccc1Cl)N1CCc2ncnc(Nc3ccc(F)c(Cl)c3)c2C1 CHEMBL4793968 IC50 43.8 nM
CC(C)Cc1ccc(-c2n[nH]c3c2C(c2ccc(N(C)C)cc2)C(C#N)=C(N)O3)cc1 CHEMBL1173535 IC50 46.0 nM
CC(C)[C@@H](NC(=O)c1cc(C(F)(F)F)ccc1F)C(=O)N1CCC2(CC1)C(=O)N(C)C(=O)N2c1cccc(Cl)c1 CHEMBL4649782 IC50 46.0 nM
O=C(CCCc1c[nH]nn1)NC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)C1 CHEMBL3935803 IC50 48.0 nM
O=C(O)CCCCC(=O)N1CCc2c(n(Cc3cccc(F)c3)c3ncccc23)C1 CHEMBL4640625 IC50 50.0 nM
CCn1cc(NC(=O)NCc2ccc(Cl)cc2)c2cc(-c3nc(CN4CCC(O)CC4)cs3)ccc21 CHEMBL5174752 IC50 50.3 nM
CCOc1c(NCCC2CN(C(=O)OCc3cc(Cl)cc(Cl)c3)CCO2)c(=O)c1=O CHEMBL3919909 IC50 51.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCOCC4)cc3)cn2c1NC(=O)OCc1ccc(F)cc1 CHEMBL5170680 IC50 51.3 nM
C[C@H](NC(=O)CCc1nc2ccncc2n1Cc1ccc(F)cc1)c1ccc(F)cc1 CHEMBL3934551 IC50 52.0 nM
O=C(CCc1ccc2[nH]c(=O)oc2c1)N1CCc2nc(NCc3cccc(Cl)c3)ncc2C1 CHEMBL4458386 IC50 52.3 nM
O=C1[C@@H]2Cc3ccc(OCc4ccc(B(O)O)cc4)cc3CN2C(=O)N1Cc1ccc(F)cc1 CHEMBL1802520 IC50 55.0 nM
O=C(CCCc1c[nH]nn1)NC1CCN(C(=O)OCc2cc(F)cc(Cl)c2)CC1 CHEMBL3954015 IC50 55.0 nM
COc1cc(/C=C2\SC(=O)N(Cc3ccc(F)cc3)C2=O)ccc1OCc1ccc(C(=O)O)cc1 CHEMBL1173803 IC50 56.0 nM
CN1CCN(S(=O)(=O)c2cc(C(=O)Nc3cc(Cl)c(F)c(Cl)c3)c(Cl)cc2Cl)CC1 CHEMBL4080953 IC50 56.0 nM
Cc1[nH]c2cc(F)c(N3CCC(C(=O)N4CCCC4)CC3)cc2c1/C(=N/Nc1nc(-c2ccc(F)cc2)c(C#N)s1)C(F)(F)F CHEMBL4789880 IC50 57.0 nM
O=C1[C@H]2Cc3ccc(OCc4ccc(B(O)O)cc4)cc3CN2C(=O)N1Cc1ccc(F)cc1 CHEMBL1802521 IC50 59.0 nM
CCc1nc2ccc(N3CCN(CC(=O)N4CC(O)C4)CC3)nn2c1N(C)c1nc(-c2ccc(F)cc2)c(C#N)s1 CHEMBL4096364 IC50 60.0 nM
CCCC[C@@H](CCCC(=O)NO)NC(=O)CCCCC(=O)Nc1ccccc1 CHEMBL4086925 IC50 60.0 nM
Cc1nnn(Cc2cc(C(F)(F)F)ccc2/C=C/C(=O)N2CCC(Cl)CC2)n1 CHEMBL4779450 IC50 60.0 nM
Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCC(Cc3nnc(C)o3)CC2)n1 CHEMBL4780243 IC50 60.0 nM
C[C@H](CCC(=O)N1CCC(Oc2ccc(B(O)O)cc2)CC1)[C@H]1CC[C@H]2C3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL5190935 EC50 60.0 nM
CCCCCCCC/C=C\CCCCCCCC(=O)NCCOP(=O)(O)O CHEMBL117754 IC50 60.0 nM
CN(CCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)C(=O)Cc1c[nH]nn1 CHEMBL3895050 IC50 62.0 nM
CCn1cc(NC(=O)OCc2cccc(Cl)c2Cl)c2cc(-c3nc(CN4CCN(CCO)CC4)cs3)ccc21 CHEMBL4644515 IC50 62.7 nM
O=C(NC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)c1nc(-c2ccc(Cl)cc2)cs1 CHEMBL4102606 IC50 63.29 nM
Cc1cc(CN2CCN(C(=O)/C=C/c3ccc(Cl)cc3Cn3nnc(C)n3)CC2)on1 CHEMBL4782227 IC50 64.0 nM
CCN(Cc1ccncc1)c1ccc(C(=O)Nc2cc(-c3ccccc3)nn2C)nn1 CHEMBL3957300 IC50 65.2 nM
CCn1cc(NC(=O)O[C@H](C)c2ccc(C)cc2)c2cc(-c3nc(CN4CCCC4)cs3)ccc21 CHEMBL5171065 IC50 65.4 nM
CN1CCN(S(=O)(=O)c2cc(C(=O)Nc3cc(F)c(F)c(F)c3)c(Cl)cc2Cl)CC1 CHEMBL4097500 IC50 67.0 nM
COc1cc(/C=C2\SC(=O)N(Cc3ccc(Cl)cc3)C2=O)ccc1OCc1ccncc1 CHEMBL1172427 IC50 68.0 nM
C[C@H](NC(=O)CCc1nc2cccnc2n1Cc1ccccc1)c1ccccc1 CHEMBL3916907 IC50 68.0 nM
CCn1cc(C(=O)N/N=C(\C)c2ccc(F)cc2)c2cc(-c3nc(CN4CCC(O)CC4)cs3)ccc21 CHEMBL4634620 IC50 69.4 nM
COc1ccc(C(CCO)Nc2ccc(C(=O)Nc3onc(C)c3C)nn2)cc1 CHEMBL3980887 IC50 69.5 nM
O=S(=O)(c1cc(C(=S)Nc2ccc(F)c(F)c2)c(Cl)cc1Cl)N1CCOCC1 CHEMBL4073772 IC50 70.0 nM
O=C(NCc1ccc(B(O)O)cc1)c1ccc(/C=C2\SC(=O)N(Cc3ccc(F)cc3)C2=O)cc1 CHEMBL1802469 IC50 71.0 nM
CCc1nc2c(C)cc(-c3ccc(CN(CCO)CCO)cc3)cn2c1NC(=O)OCc1cc(Cl)cc(Cl)c1 CHEMBL5192468 IC50 71.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCOCC4)cc3)cn2c1NC(=O)NCc1ccc(OC)c(Cl)c1 CHEMBL4850086 IC50 71.7 nM
CCCCCCCCCC(=O)Nc1ccc(C(F)P(=O)(O)O)cc1 CHEMBL1818150 Ki 72.0 nM
CCn1cc(/C(=N/Nc2nc3ccccc3s2)C(F)(F)F)c2cc(-c3nc(CN4CCC[C@H]4C(=O)O)cs3)ccc21 CHEMBL4783483 IC50 72.0 nM
O=C(NCCN1CCNC1=O)c1ccc(NC2Cc3ccccc3C2)nn1 CHEMBL3948632 IC50 73.8 nM
COc1ccc2c(Sc3cccc(C(=O)O)n3)c(C)n(-c3cnn(C)c3)c2c1 CHEMBL4065406 IC50 75.0 nM
O=C(OCc1ccccc1)N1CCC(Nc2nc(-c3ccc(CP(=O)(O)O)cc3)cs2)CC1 CHEMBL4072746 IC50 75.9 nM
O=C(CCCc1c[nH]nn1)NC1CCN(C(=O)/C=C/c2ccc(Cl)cc2Cl)CC1 CHEMBL3951756 IC50 77.0 nM
O=C(CCCCc1nnc[nH]1)N1CCc2nc(NC3Cc4ccccc4C3)ncc2C1 CHEMBL4561467 IC50 79.0 nM
COc1ccc(CNC(=O)Nc2c(C)nc3c(C)cc(-c4ccc(CN5CCN(CCO)CC5)cc4)cn23)cc1Cl CHEMBL4874879 IC50 79.1 nM
C[C@H](NC(=O)NCc1nc2cccnc2n1Cc1ccc(F)cc1)c1ccc(F)cc1 CHEMBL3945659 IC50 80.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCN(CCO)CC4)cc3)cn2c1NC(=O)OCc1ccc(C(F)(F)F)cc1 CHEMBL5179219 IC50 81.0 nM
CC(C)(OCC(=O)N1CCc2c(n(Cc3cccc(F)c3)c3ncccc23)C1)C(=O)O CHEMBL3677652 IC50 83.0 nM
O=C(Nc1cc(F)c(Cl)c(F)c1)c1cc(S(=O)(=O)N2CCOCC2)c(Cl)cc1Cl CHEMBL4082022 IC50 84.0 nM
CCc1nc2ccc(C3CCN(CC(=O)N4CCCC4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)cs1 CHEMBL4100092 IC50 86.0 nM
O=C(NCCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)c1c[nH]c(=O)o1 CHEMBL3925648 IC50 86.0 nM
O=C(CCCc1c[nH]nn1)NC1CCN(C(=O)CCc2ccc(C(F)(F)F)cc2)CC1 CHEMBL3925811 IC50 87.0 nM
Cc1c(Cc2cccc(C(=O)O)n2)c2ccc(Cl)cc2n1-c1cnn(C)c1 CHEMBL4102520 IC50 89.0 nM
O=C(NCCCn1ccnc1)c1ccc(NCc2cc(Cl)cc(Cl)c2)nn1 CHEMBL3972860 IC50 89.2 nM
O=C(O)CCCCC(=O)N1CCc2c(n(CCC3CCCCC3)c3ncccc23)C1 CHEMBL3677648 IC50 91.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCSCC4)cc3)cn2c1NC(=O)OCc1cc(Cl)cc(Cl)c1 CHEMBL5190828 IC50 91.0 nM
CN(C(=O)CCCc1c[nH]nn1)C1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL3978525 IC50 93.0 nM
O=C1S/C(=C\c2cccc(B(O)O)c2)C(=O)N1Cc1ccc(F)cc1 CHEMBL1632621 Ki 94.0 nM
Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCNC[C@H]2C)n1 CHEMBL4740639 IC50 95.0 nM
CCCCCCC/C=C/CCCCCCCC[C@@H]1OC[C@H](COP(=O)([O-])O)O1 CHEMBL436763 IC50 97.0 nM
O=S(=O)(c1cc(C(=S)Nc2cc(Cl)c(F)c(Cl)c2)c(Cl)cc1Cl)N1CCOCC1 CHEMBL4099620 IC50 98.0 nM
CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O CHEMBL117021 Ki 100.0 nM
CC1CCC(C(C)C)C(OCC(=O)N2CCC(CCCC3CCN(c4ccc(C(=O)N5CCCC5C(N)=O)cc4)CC3)CC2)C1 CHEMBL2418930 Ki 100.0 nM
Cc1noc(NC(=O)c2ccc(NC(C)c3ccc(Cl)cc3)nn2)c1C CHEMBL3943299 IC50 100.0 nM
CN1CCN(S(=O)(=O)c2cc(C(=S)Nc3cc(Cl)c(F)c(Cl)c3)c(Cl)cc2Cl)CC1 CHEMBL4105201 IC50 100.0 nM
Cc1c(Sc2cccc(C(=O)O)c2)c2ccc(Cl)cc2n1C CHEMBL4063573 IC50 100.0 nM
C[C@H](CCC(=O)N1CCC(O)(CNC(=O)OCc2cc(Cl)cc(Cl)c2)CC1)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL4093316 IC50 100.0 nM
CC(C)[C@@H](NC(=O)c1cc(C(F)(F)F)ccc1F)C(=O)N1CCC2(CC1)C(=O)N(C)C(=O)N2c1ccccc1 CHEMBL4644106 IC50 100.0 nM
O=C(O)c1cccc(CC(=O)N2CCc3c(n(Cc4cccc(F)c4)c4ncccc34)C2)c1 CHEMBL4643425 IC50 100.0 nM
C[C@H]1CC[C@@H](Oc2ccc3ccc(CN4C5CCC4CC(C(=O)O)C5)cc3c2C(F)(F)F)CC1 CHEMBL4859055 IC50 100.0 nM
C[C@H](CCC(=O)N1CCC(Oc2ccc([B-](F)(F)F)cc2)CC1)[C@H]1CC[C@H]2C3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL5196449 EC50 100.0 nM
CCn1cc(NC(=O)NCc2ccc(F)cc2)c2cc(NC(=O)c3ccc(CN4CCN(CCO)CC4)cc3)ccc21 CHEMBL4754625 IC50 101.0 nM
CCn1cc(NC(=O)NCc2ccc(F)cc2)c2cc(-c3nc(CN4CCN(CCO)CC4)cs3)ccc21 CHEMBL5201612 IC50 101.0 nM
CCc1nc2cnc(N3CCN(CC(=O)N4CC(O)C4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)c(C#N)s1 CHEMBL4075483 IC50 102.0 nM
Cc1ccc(F)c(CNc2ccc(C(=O)Nc3onc(C)c3C)nn2)c1F CHEMBL3929637 IC50 103.0 nM
CCc1nc2c(C)cc(C3CCN(CC(=O)N4CC(O)C4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)c(C#N)s1 CHEMBL4091174 IC50 103.0 nM
Cc1[nH]c2cc(F)c(N3CCC(C(=O)N4CCOCC4)CC3)cc2c1/C=N/Nc1nc(-c2ccc(F)cc2)c(C#N)s1 CHEMBL4780733 IC50 104.0 nM
CCCCCCCCc1ccc(CCCCCCC2OCC(COP(=O)([O-])O)O2)cc1 CHEMBL199380 IC50 106.0 nM
CCn1cc(NC(=O)NCc2ccc(Cl)cc2)c2cc(NC(=O)c3ccc(CN4CCOCC4)cc3)ccc21 CHEMBL4776884 IC50 107.0 nM
CCn1cc(/C(=N/Nc2nc3ccccc3s2)C(F)(F)F)c2cc(-c3nc(CN4CCCCC4)cs3)ccc21 CHEMBL4800474 IC50 107.0 nM
CCn1cc(C(=O)N/N=C/c2ccc3c(c2)OCO3)c2cc(-c3nc(CN4CCC(O)CC4)cs3)ccc21 CHEMBL4638125 IC50 107.4 nM
O=C(/C=C/c1c[nH]cn1)NC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL3903906 IC50 109.0 nM
O=C(O)C1CCCN(CC(=O)N2CCc3c(n(Cc4cccc(F)c4)c4ncccc34)C2)C1 CHEMBL3677657 IC50 110.0 nM
CCn1cc(NC(=O)NCc2ccc(F)cc2)c2cc(NC(=O)c3ccc(CN4CCOCC4)cc3)ccc21 CHEMBL4759554 IC50 110.0 nM
CCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O CHEMBL1615121 IC50 110.0 nM
CCCCCn1c(N2CCC[C@H](C(=O)O)C2)cc(=O)n2cc(-c3ccc(Cl)cc3)nc12 CHEMBL5269381 IC50 110.0 nM
Cn1c(=O)n(C)c2cc(/C=C3\SC(=O)N(Cc4ccccc4)C3=O)ccc21 CHEMBL1173301 IC50 111.0 nM
O=C(CCCc1c[nH]nn1)NC1CCN(C(=O)CCc2ccc(Cl)cc2Cl)CC1 CHEMBL3931088 IC50 113.0 nM
Cc1noc(NC(=O)c2ccc(NCc3cccc4ccccc34)nn2)c1C CHEMBL3936715 IC50 114.0 nM
CCn1cc(/C(=N/Nc2nc3ccccc3s2)C(F)(F)F)c2cc(-c3nc(CN4CCN(C)CC4)cs3)ccc21 CHEMBL4800586 IC50 116.0 nM
CCn1cc(NC(=O)O[C@H](C)c2ccc(C)cc2)c2cc(-c3nc(CN4CCC(O)CC4)cs3)ccc21 CHEMBL4644727 IC50 117.0 nM
O=C(CCCc1c[nH]nn1)NC1CCN(C(=O)CCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL3916571 IC50 119.0 nM
CCCCCCC/C=C/CCCCCCCC[C@H]1OC[C@H](COP(=O)([O-])O)O1 CHEMBL371955 IC50 120.0 nM
O=S(=O)(c1cc(C(=S)Nc2cccc(F)c2)c(Cl)cc1Cl)N1CCOCC1 CHEMBL4102111 IC50 121.0 nM
CCn1cc(NC(=O)OCc2ccccc2)c2cc(-c3nc(CN4CCC[C@H]4CO)cs3)ccc21 CHEMBL4636755 IC50 121.8 nM
CCc1nc2ccc(C(=O)NCCO)cn2c1N(C)c1nc(-c2ccc(Cl)cc2)cs1 CHEMBL4084750 IC50 122.0 nM
O=C(CCCCc1cc[nH]n1)N1CCc2nc(NC3Cc4ccccc4C3)ncc2C1 CHEMBL4456849 IC50 123.0 nM
CCc1nc2ccc(C3CCN(S(C)(=O)=O)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2C#N)cs1 CHEMBL4069323 IC50 126.0 nM
CCn1cc(/C(=N/Nc2nc3ccccc3s2)C(F)(F)F)c2cc(-c3nc(CN4CCCC4)cs3)ccc21 CHEMBL4778510 IC50 126.0 nM
CCn1cc(NC(=O)OCc2cccc(Cl)c2Cl)c2cc(-c3nc(CN4CCC(O)CC4)cs3)ccc21 CHEMBL4638854 IC50 127.0 nM
CCn1cc(NC(=O)NCc2ccc(F)cc2)c2cc(-c3nc(CN4CCC(C)CC4)cs3)ccc21 CHEMBL5193035 IC50 127.0 nM
C[C@H](CCC(=O)N1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL4081367 IC50 129.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCOCC4)cc3)cn2c1NC(=O)OCc1cc(Cl)cc(Cl)c1 CHEMBL5201210 IC50 129.0 nM
O=C(CCN1CCN(C(=O)OCc2ccccc2)CC1)c1ccc2[nH]c(=O)oc2c1 CHEMBL4130315 IC50 130.0 nM
O=C(OCc1cc(Cl)cc(Cl)c1)N1CCN(C2CN(C(=O)c3ccc4c(c3)B(O)OC4)C2)CC1 CHEMBL5266101 IC50 130.0 nM
O=C(CCc1cc(O)no1)NCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL3970339 IC50 131.0 nM
N#CC1=C(N)Oc2n[nH]c(-c3ccc(OCc4ccc(F)cc4)cc3)c2[C@H]1c1ccc(Cl)c(Cl)c1 CHEMBL5434693 IC50 134.0 nM
CCn1cc(C(=O)N/N=C/c2ccc(F)cc2)c2cc(-c3nc(CN4CCN(CCO)CC4)cs3)ccc21 CHEMBL4636225 IC50 134.9 nM
O=C(O)CCCCCCC(=O)NC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL3924051 IC50 135.0 nM
CCc1nc2ccc(C3CCN(S(C)(=O)=O)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)c(C#N)s1 CHEMBL4095636 IC50 138.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCCC4)cc3)cn2c1NC(=O)OCc1cc(Cl)cc(Cl)c1 CHEMBL5200077 IC50 140.0 nM
CCCCCCC/C=C/CCCCCCCCC1OCC(COP(=O)([O-])O)O1 CHEMBL373007 IC50 141.0 nM
O=C(Nc1ccc(B(O)O)cc1)c1ccc(/C=C2\SC(=O)N(Cc3ccc(F)cc3)C2=O)cc1 CHEMBL1802468 IC50 147.0 nM
CN(CCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)C(=O)c1c[nH]nn1 CHEMBL3974814 IC50 150.0 nM
O=C(CCCc1c[nH]nn1)NC1CCN(C(=O)COc2cc(Cl)cc(Cl)c2)CC1 CHEMBL3901277 IC50 154.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCN(C)CC4)cc3)cn2c1NC(=O)OCc1ccc(F)c(F)c1 CHEMBL5204526 IC50 154.0 nM
CN(CCCN1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)C(=O)c1c[nH]c(=O)o1 CHEMBL3905340 IC50 156.0 nM
CCn1cc(NC(=O)NCc2ccc(Cl)cc2)c2cc(-c3nc(CN4CCN(CCO)CC4)cs3)ccc21 CHEMBL4759866 IC50 156.0 nM
CCN1CCN(C(=O)C2CCN(c3cc4c(/C=N/Nc5nc(-c6ccc(F)cc6)c(C#N)s5)c(C)[nH]c4cc3F)CC2)CC1 CHEMBL4783759 IC50 159.0 nM
CCOc1cc(/C=C2\SC(=O)N(Cc3ccccc3)C2=O)ccc1OCc1ccc(C(=O)O)cc1 CHEMBL1173802 IC50 161.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCCCC4)cc3)cn2c1NC(=O)OCc1cc(Cl)cc(Cl)c1 CHEMBL5189263 IC50 164.0 nM
CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)C[C@@H](Br)P(=O)(O)O CHEMBL3621355 IC50 165.0 nM
COc1ccc(-c2nc(N/N=C(/c3c(C)[nH]c4cc(F)c(N5CCN(CCN(C)C)CC5)cc34)C(F)(F)F)sc2C#N)cc1 CHEMBL4789070 IC50 167.0 nM
CCCCCCCCCCCCCCc1ccc(CP(=O)(O)O)cc1 CHEMBL3828165 IC50 170.0 nM
O=C(CCN1CCN(C(=O)OCC2CCCC2)CC1)c1ccc2[nH]c(=O)oc2c1 CHEMBL4129365 IC50 170.0 nM
CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)CC(Br)P(=O)(O)O CHEMBL1632624 IC50 170.3 nM
CCn1cc(NC(=O)OCc2ccc(F)c(F)c2)c2cc(-c3nc(CN4CCCC4)cs3)ccc21 CHEMBL5204085 IC50 171.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCN(CC)CC4)cc3)cn2c1NC(=O)OCc1ccc(F)c(F)c1 CHEMBL5175013 IC50 171.0 nM
CCCCCCC/C=C/CCCCCCCC[C@H]1OC[C@@H](COP(=O)([O-])O)O1 CHEMBL370846 IC50 178.0 nM
CN1CCN(C2=NC(=O)/C(=C/c3ccc(Cl)c(Cl)c3)S2)CC1 CHEMBL4569898 IC50 180.0 nM
CCn1cc(C(=O)N/N=C/c2ccc(Cl)cc2)c2cc(-c3nc(CN4CCC(O)CC4)cs3)ccc21 CHEMBL4639826 IC50 180.0 nM
O=C(O)c1cccc(/C=C2\SC(=O)N(Cc3ccc(F)cc3)C2=O)c1 CHEMBL1632622 Ki 187.0 nM
N#Cc1c(F)cc(NC(=O)c2cc(S(=O)(=O)N3CCOCC3)c(Cl)cc2Cl)cc1F CHEMBL4071490 IC50 190.0 nM
CCn1cc(NC(=O)NCc2ccc(F)cc2)c2cc(NC(=O)c3ccc(CN4CCN(C)CC4)cc3)ccc21 CHEMBL4777413 IC50 190.0 nM
CCc1nc2ccc(C3CCN(CC(=O)N4CC(O)C4)CC3)nn2c1N(C)c1ccc(C#N)c(-c2ccc(F)cc2)n1 CHEMBL4095546 IC50 192.0 nM
CCn1cc(NC(=O)NCc2ccc(Cl)cc2)c2cc(-c3nc(CN4CCN(C)CC4)cs3)ccc21 CHEMBL4800452 IC50 199.0 nM
CCn1cc(NC(=O)O[C@H](C)c2ccccc2Cl)c2cc(-c3nc(CN4CCC[C@H]4CO)cs3)ccc21 CHEMBL4634766 IC50 199.4 nM
CCCCCCCCc1ccc(CCC(N)(CO)CCCP(=O)(O)O)cc1 CHEMBL570352 Ki 200.0 nM
CC(O)C(NC(=O)c1ccc(N2CCC(CCCC3CCN(C(=O)Cc4ccc(-c5ccccc5)cc4)CC3)CC2)nc1)C(N)=O CHEMBL2418934 Ki 200.0 nM
CCn1cc(/C(=N/Nc2nc3ccccc3s2)C(F)(F)F)c2cc(-c3nc(CN4CCOCC4)cs3)ccc21 CHEMBL4782735 IC50 201.0 nM
C[C@H](CCC(=O)NCCNC(=O)OCc1cc(Cl)cc(Cl)c1)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL4105619 IC50 202.0 nM
Cc1c(Oc2cccc(C(=O)O)c2)c2ccc(Cl)cc2n1-c1cnn(C)c1 CHEMBL4086139 IC50 204.0 nM
O=C(CCCc1c[nH]nn1)NC1CCN(C(=O)OCc2ccc(Cl)cc2Cl)CC1 CHEMBL3903546 IC50 206.0 nM
C[C@H](CCC(=O)NC1CC(NC(=O)OCc2cc(Cl)cc(Cl)c2)C1)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL4090866 IC50 208.0 nM
CCn1cc(NC(=O)O[C@H](C)c2ccccc2Cl)c2cc(-c3nc(CN4CCC(O)CC4)cs3)ccc21 CHEMBL4643457 IC50 210.0 nM
CCc1nc2c(C)cc(-c3ccc(C(=O)N4CCN(C)CC4)cc3)cn2c1NC(=O)NCc1ccc(OC)c(Cl)c1 CHEMBL4872835 IC50 213.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCN(C)CC4)cc3)cn2c1NC(=O)OCc1cc(Cl)cc(Cl)c1 CHEMBL5179154 IC50 217.0 nM
CS(=O)(=O)N(c1cc(C(=O)Nc2cc(F)c(Cl)c(F)c2)c(Cl)cc1Cl)C1CCOCC1 CHEMBL5395463 IC50 218.0 nM
CS(=O)(=O)N(c1cc(C(=O)Nc2cc(F)c(F)c(F)c2)c(Cl)cc1Cl)C1CCOCC1 CHEMBL5438529 IC50 219.0 nM
CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)OC CHEMBL2017135 IC50 220.2 nM
C[C@H](c1ccc2ccc(O[C@H]3CC[C@@H](C)CC3)c(C(F)(F)F)c2c1)N1C2CCC1CC(C(=O)O)C2 CHEMBL4847281 IC50 230.0 nM
CCc1nc2ccc(N3CCN(CC(=O)N4CCOCC4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)cs1 CHEMBL4073251 IC50 231.0 nM
CCn1cc(C(=O)N/N=C/c2ccc(Cl)cc2)c2cc(-c3nc(CN4CCN(CCO)CC4)cs3)ccc21 CHEMBL4643989 IC50 231.1 nM
CCCCCCCCCCCCC1OCC(COP(=O)([O-])O)O1 CHEMBL381470 IC50 232.0 nM
CCn1cc(NC(=O)NCc2ccc(F)cc2)c2cc(-c3nc(CN(CCO)CCO)cs3)ccc21 CHEMBL4752284 IC50 234.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCN(CC)CC4)cc3)cn2c1NC(=O)OCc1ccc(C(F)(F)F)cc1 CHEMBL5204769 IC50 234.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCC(O)CC4)cc3)cn2c1NC(=O)NCc1ccc(Cl)cc1 CHEMBL4858110 IC50 237.0 nM
CCCCCCC/C=C/CCCCCCCC[C@@H]1OC[C@@H](COP(=O)([O-])O)O1 CHEMBL382116 IC50 238.0 nM
O=C(CCN1CCN(C(=O)OCC2CCCCC2)CC1)c1ccc2[nH]c(=O)oc2c1 CHEMBL4127038 IC50 240.0 nM
O=C(O)CCCCC(=O)N1CCc2c(n(Cc3ccccc3)c3ncccc23)C1 CHEMBL4641471 IC50 240.0 nM
CCn1cc(NC(=O)NCc2ccc(Cl)cc2)c2cc(-c3nc(CN4CCC(C)CC4)cs3)ccc21 CHEMBL5175577 IC50 242.0 nM
CCc1nc2ccc(C3CCN(CC(=O)N4CC(O)C4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)cs1 CHEMBL4063869 IC50 246.0 nM
COc1cc(/C=C2\SC(=O)N(Cc3ccccc3)C2=O)ccc1OCc1ccc(C(=O)O)cc1 CHEMBL1173629 IC50 248.0 nM
Cc1noc(NC(=O)c2ccc(NCc3cccc(Cl)c3Cl)nn2)c1C CHEMBL3970527 IC50 248.0 nM
COc1c(N(C)CCC2CCN(C(=O)OCc3cc(Cl)cc(Cl)c3)CC2)c(=O)c1=O CHEMBL3909512 IC50 248.0 nM
CCCCCCCN/C=C1\C(=O)N(c2ccc(F)cc2)C(=O)N=C1O CHEMBL4533486 IC50 250.0 nM
O=C(O)CCCCCC(=O)N1CCc2c(n(Cc3ccccc3)c3ncccc23)C1 CHEMBL4648748 IC50 250.0 nM
CCCCCCC/C=C/CCCCCCCC[C@H]1OC[C@H](COP([O-])(O)=S)O1 CHEMBL427014 IC50 252.0 nM
CCn1cc(NC(=O)NCc2ccc(F)cc2)c2cc(-c3nc(CN4CCOCC4)cs3)ccc21 CHEMBL4782661 IC50 252.0 nM
CCc1nc2c(C)cc(-c3ccc(C(=O)N4CCN(C)CC4)cc3)cn2c1NC(=O)NCc1ccc(F)cc1 CHEMBL4872539 IC50 257.0 nM
Cc1c(Sc2cccc(C(=O)O)n2)c2cc(Cl)ccc2n1-c1cnn(C)c1 CHEMBL4068117 IC50 258.0 nM
O=C(CSc1nc2ccc(N3C(=O)c4ccccc4C3=O)cc2s1)Nc1cccc(Cl)c1 CHEMBL1173377 IC50 261.0 nM
CCc1nc2ccc(C3CCN(CC(=O)N(C)C)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)cs1 CHEMBL4064663 IC50 261.0 nM
O=C(CCCc1c[nH]nn1)N[C@@H]1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)C1 CHEMBL4110182 IC50 263.0 nM
COc1cc(-c2ccc(/N=N/c3c(S(=O)(=O)O)cc4cc(S(=O)(=O)O)cc(N)c4c3O)c(OC)c2)ccc1/N=N/c1c(S(=O)(=O)O)cc2cc(S(=O)(=O)O)cc(N)c2c1O CHEMBL1091750 Ki 271.0 nM
CN(CCC1CCN(C(=O)/C=C/c2cc(Cl)cc(Cl)c2)CC1)C(=O)c1c[nH]c(=O)o1 CHEMBL3954618 IC50 274.0 nM
CCc1nc2ccc(N3CCN(CC(=O)N4CC(O)C4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)cs1 CHEMBL4098810 IC50 274.0 nM
CCn1cc(NC(=O)OCc2cc(Cl)cc(Cl)c2)c2cc(-c3nc(CN4CCN(C)CC4)cs3)ccc21 CHEMBL5177856 IC50 279.0 nM
CCOC(=O)CN1CCN(c2ccc3nc(CC)c(N(C)c4nc(-c5ccc(F)cc5)cs4)n3c2)CC1 CHEMBL4066101 IC50 280.0 nM
CCn1cc(NC(=O)NCc2ccc(F)cc2)c2cc(NC(=O)c3ccc(CN4CCCC4)cc3)ccc21 CHEMBL4756394 IC50 280.0 nM
O=C(NCCCN1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)c1c[nH]nn1 CHEMBL3944238 IC50 282.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCOCC4)cc3)cn2c1NC(=O)NCc1ccc(Cl)cc1 CHEMBL4877202 IC50 283.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCSCC4)cc3)cn2c1NC(=O)OCc1ccc(F)c(F)c1 CHEMBL5200527 IC50 287.0 nM
Cc1[nH]c2cc(Cl)ccc2c1Sc1cccc(C(=O)O)c1 CHEMBL4083623 IC50 290.0 nM
CCc1nc2ccc(C3CCN(CC(=O)N4CC(O)C4)CC3)nn2c1N(C)c1nc(-c2ccc(F)cc2C#N)ns1 CHEMBL4064872 IC50 297.0 nM
CCn1cc(NC(=O)OCc2ccc(F)c(F)c2)c2cc(-c3nc(CN4CCC[C@H]4CO)cs3)ccc21 CHEMBL4642973 IC50 297.2 nM
Cc1nc2ccccn2c(=O)c1Cc1ccc(Cl)cc1 CHEMBL4520245 IC50 300.0 nM
CC1CC(CNC(=O)CCc2cc(O)no2)CCN1C(=O)OCc1cc(Cl)cc(Cl)c1 CHEMBL3923031 IC50 313.0 nM
C[C@H](CCC(=O)N1CC[C@@H](NC(=O)OCc2cc(Cl)cc(Cl)c2)C1)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL4071554 IC50 313.0 nM
CCn1cc(NC(=O)NCc2ccc(F)cc2)c2cc(-c3nc(CN4CCC(O)CC4)cs3)ccc21 CHEMBL4752916 IC50 313.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCN(C)CC4)cc3)cn2c1NC(=O)OCc1ccc(C(F)(F)F)cc1 CHEMBL5194595 IC50 313.0 nM
COc1cc(COc2ccc(B(O)O)cc2Cl)cc(OC)c1 CHEMBL4086456 pIC50 316.23 nM
CCn1cc(NC(=O)NCc2ccccc2)c2cc(-c3nc(CN4CCOCC4)cs3)ccc21 CHEMBL5190063 IC50 318.0 nM
O=C(CCc1nc2cccnc2n1Cc1ccccc1)NCc1ccc(F)cc1 CHEMBL3971187 IC50 324.0 nM
C[C@H](c1ccc2ccc(O[C@H]3CC[C@@H](C)CC3)c(C(F)(F)F)c2c1)N1C2CCCC1CC(C(=O)O)C2 CHEMBL4858465 IC50 330.0 nM
CCn1cc(/C(=N/Nc2nc3ccccc3s2)C(F)(F)F)c2cc(-c3nc(CN4CCC(C)CC4)cs3)ccc21 CHEMBL4789626 IC50 337.0 nM
CC(C)[C@@H](NC(=O)c1cccc(C(F)(F)F)c1)C(=O)N1CCC2(CC1)C(=O)N(C)C(=O)N2c1ccc2[nH]ncc2c1 CHEMBL4647181 IC50 340.0 nM
CCCCCCC/C=C/CCCCCCCC[C@@H]1OC[C@H](COP([O-])(O)=S)O1 CHEMBL199400 IC50 344.0 nM
Cc1c(Sc2cccc(C(=O)O)n2)c2ccc(F)cc2n1-c1ccn(C)n1 CHEMBL4094567 IC50 349.0 nM
CNC(=O)CN1CN(c2ccccc2)C2(CCN(C(=O)[C@H](NC(=O)c3ccccc3)C3CCCCC3)CC2)C1=O CHEMBL4638762 IC50 350.0 nM
CCn1cc(NC(=O)NCc2ccc(Cl)cc2)c2cc(NC(=O)c3ccc(CN4CCCC4)cc3)ccc21 CHEMBL4763503 IC50 351.0 nM
CCn1cc(NC(=O)OCc2cc(Cl)cc(Cl)c2)c2cc(-c3nc(CN4CCC(C)CC4)cs3)ccc21 CHEMBL5193512 IC50 354.0 nM
CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)S)OC CHEMBL2017140 IC50 355.6 nM
Cc1noc(NC(=O)c2ccc(NC3CCN(Cc4ccccc4)C3)nn2)c1C CHEMBL3899342 IC50 357.0 nM
CCc1nc2ccc(C3CCN(S(=O)(=O)CCCN(C)C)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)cs1 CHEMBL4081493 IC50 357.0 nM
Cc1oc(=O)[nH]c1C(=O)N(C)CCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL3955141 IC50 360.0 nM
CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)O)OC CHEMBL2017133 IC50 361.1 nM
CCCCCCC/C=C/CCCCCCCC[C@@H]1OC[C@@H](COP([O-])(O)=S)O1 CHEMBL200003 IC50 363.0 nM
C[C@H](NC(=O)OCc1nc2cccnc2n1Cc1ccc(F)cc1)c1ccc(F)cc1 CHEMBL3899987 IC50 366.0 nM
CCCCCCCCCCCCCC(=O)Nc1ccc(CP(=O)(O)O)cc1 CHEMBL1632623 Ki 367.0 nM
O=C(NCCN1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)c1c[nH]c(=O)o1 CHEMBL3918040 IC50 370.0 nM
CCn1cc(NC(=O)NCc2ccc(F)cc2)c2cc(NC(=O)c3ccc(CN4CCC(C)CC4)cc3)ccc21 CHEMBL4759103 IC50 370.0 nM
O=C(O)C1CCN(Cc2ccc3c(C(F)(F)F)c(O[C@H]4CC[C@@H](C(F)(F)F)CC4)ccc3c2)CC1 CHEMBL4846048 IC50 370.0 nM
O=C(NCCC1CCN(C(=O)/C=C/c2cc(Cl)cc(Cl)c2)CC1)c1c[nH]c(=O)o1 CHEMBL3959262 IC50 387.0 nM
CCCCCCCCCCCCCCCC(=O)N[C@@H](Cc1ccc(OCc2ncc(C)c(OC)c2C)cc1)[C@@H](O)CP(=O)(O)O CHEMBL1632521 Ki 390.0 nM
O=C(CCc1cc(O)no1)NC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL3967612 IC50 396.0 nM
O=S(=O)(c1cc(CNc2cc(F)c(F)c(F)c2)c(Cl)cc1Cl)N1CCOCC1 CHEMBL4084129 IC50 396.0 nM
CCCCCCC/C=C/CCCCCCCC[C@H]1OC[C@@H](COP([O-])(O)=S)O1 CHEMBL425218 IC50 403.0 nM
CCn1cc(C(=O)O)c2cc(-c3nc(CN4CCN(CCO)CC4)cs3)ccc21 CHEMBL4755901 IC50 410.0 nM
CCCCCCC/C=C/CCCCCCCCC1OCC(COP([O-])(O)=S)O1 CHEMBL199472 IC50 415.0 nM
CCN1CCN(C2=NC(=O)/C(=C/c3ccc(Cl)cc3)S2)CC1 CHEMBL4563827 IC50 420.0 nM
COc1cc(/C=C2\SC(=O)N(Cc3ccc([N+](=O)[O-])cc3)C2=O)ccc1OCc1ccc(C(=O)O)cc1 CHEMBL1173630 IC50 442.0 nM
O=C(CCc1nc2cccnc2n1Cc1ccccc1)NCC1CCCCC1 CHEMBL3965701 IC50 444.0 nM
CCOc1c(NCCC2CCN(C(=O)OCc3cc(Cl)cc(Cl)c3)CC2)c(=O)c1=O CHEMBL3946327 IC50 445.0 nM
CCCCCCCCc1ccc(CCCCCCC2OCC(COP([O-])(O)=S)O2)cc1 CHEMBL198406 IC50 449.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCN(C)CC4)cc3)cn2c1NC(=O)NCc1ccc(F)cc1 CHEMBL4871571 IC50 451.0 nM
CCn1cc(NC(=O)O[C@H](C)c2ccccc2Cl)c2cc(-c3nc(CN4CCN(C)CC4)cs3)ccc21 CHEMBL5184161 IC50 479.0 nM
CCOC(=O)CN1CCC(c2ccc3nc(CC)c(N(C)c4nc(-c5ccc(F)cc5)cs4)n3c2)CC1 CHEMBL4087476 IC50 480.0 nM
CCc1nc2ccc(C3CCN(S(C)(=O)=O)CC3)cn2c1N(C)c1nc(-c2ccc(Cl)nc2)cs1 CHEMBL4083879 IC50 493.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCC[C@H]4CO)cc3)cn2c1NC(=O)NCc1ccc(OC)c(Cl)c1 CHEMBL4873609 IC50 497.0 nM
CC(O)C(NC(=O)c1ccc(N2CCC(CCCC3CCN(C(=O)CCC(=O)c4ccccc4)CC3)CC2)nc1)C(N)=O CHEMBL2418932 Ki 500.0 nM
C[C@H](CCC(=O)N1CC[C@H](NC(=O)OCc2cc(Cl)cc(Cl)c2)C1)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL4094214 IC50 500.0 nM
COCCc1ccc(OCc2cccc(B(O)O)c2)cc1 CHEMBL4095509 pIC50 501.19 nM
NS(=O)(=O)c1cc(-c2csc(C(=O)NC3CCN(C(=O)OCc4ccccc4)CC3)n2)ccc1Cl CHEMBL4077079 IC50 504.5 nM
Cc1cc(NC(=O)c2ccc(NC(CO)Cc3ccc(Cl)cc3)nn2)n(C)n1 CHEMBL3975633 IC50 507.0 nM
CCn1cc(C(=O)N/N=C(\C)c2ccc(F)cc2)c2cc(-c3nc(CN4CCN(CCO)CC4)cs3)ccc21 CHEMBL4646372 IC50 507.9 nM
CCCCCCC(=O)Nc1ccc(CP(=O)(O)O)cc1 CHEMBL1818151 Ki 512.0 nM
CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)S)OC CHEMBL2017138 IC50 512.0 nM
O=C(NCCC1CN(C(=O)OCc2cc(Cl)cc(Cl)c2)CCO1)c1c[nH]c(=O)o1 CHEMBL3935054 IC50 520.0 nM
CN(CCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)C(=O)c1cc(O)[nH]n1 CHEMBL3976120 IC50 520.0 nM
CC(=O)N1CCc2nc(NC3Cc4ccccc4C3)ncc2C1 CHEMBL4588676 IC50 520.0 nM
CCn1cc(NC(=O)NCc2ccc(F)cc2)c2cc(NC(=O)c3ccc(CN4CCCCC4)cc3)ccc21 CHEMBL4756110 IC50 530.0 nM
CCc1nc2ccc(C3CCN(S(C)(=O)=O)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2C)cs1 CHEMBL4104285 IC50 533.0 nM
CCOc1c(N(C)CCC2CN(C(=O)OCc3cc(Cl)cc(Cl)c3)CCO2)c(=O)c1=O CHEMBL3919542 IC50 540.0 nM
CN(CCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)C(=O)c1nn[nH]n1 CHEMBL3919506 IC50 541.0 nM
O=C(O)CCCCC(=O)NC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL3900036 IC50 543.0 nM
O=C(CCCc1c[nH]nn1)NC1CC2CCC(C1)N2C(=O)OCc1cc(Cl)cc(Cl)c1 CHEMBL3950040 IC50 555.0 nM
CCn1cc(/C(=N/Nc2nc(-c3ccc(OC)cc3)c(C#N)s2)C(F)(F)F)c2cc(-c3nc(CN4CCC(O)CC4)cs3)ccc21 CHEMBL4778972 IC50 560.0 nM
C[C@H](CCC(=O)NCCCNC(=O)OCc1cc(Cl)cc(Cl)c1)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL4070768 IC50 563.0 nM
O=C(CCc1cc(O)no1)NCCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL3890928 IC50 586.0 nM
CCn1cc(C(=O)O)c2cc(-c3nc(CN4CCC[C@H]4CO)cs3)ccc21 CHEMBL4746859 IC50 590.0 nM
CCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)S)OC CHEMBL2017137 IC50 595.8 nM
O=C(NCCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)c1nn[nH]n1 CHEMBL3983326 IC50 596.0 nM
CCCCCCCC(=O)OC[C@H](COP(O)(O)=S)OC(=O)CCCCCCC CHEMBL202361 IC50 597.0 nM
CCn1cc(C(=O)N/N=C/c2ccc3c(c2)OCO3)c2cc(-c3nc(CN4CCC[C@H]4CO)cs3)ccc21 CHEMBL4637140 IC50 610.0 nM
CCn1cc(/C(=N/Nc2nc(-c3ccc(F)cc3)c(C#N)s2)C(F)(F)F)c2cc(-c3nc(CN4CCC[C@H]4C(=O)O)cs3)ccc21 CHEMBL4797128 IC50 610.0 nM
CCn1cc(NC(=O)OCc2cc(Cl)cc(Cl)c2)c2cc(-c3nc(CN4CCC(O)CC4)cs3)ccc21 CHEMBL4635930 IC50 613.0 nM
Cc1cccc(C(=O)N[C@@H](C(=O)N2CCC3(CC2)C(=O)N(C)CN3c2ccccc2)C2CCOCC2)c1 CHEMBL4646439 IC50 623.0 nM
CN(CCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)C(=O)c1coc(=O)[nH]1 CHEMBL3899913 IC50 624.0 nM
CCc1nc2c(C)cc(-c3ccc(C(=O)N4CCCCC4)cc3)cn2c1NC(=O)NCc1ccc(F)cc1 CHEMBL4860039 IC50 626.0 nM
Cc1ccc(CNC(=O)CCc2nc3cccnc3n2Cc2ccccc2)cc1 CHEMBL1316911 IC50 627.0 nM
CN(CCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)C(=O)c1cc(O)no1 CHEMBL3986447 IC50 644.0 nM
Cc1onc(-c2ccccc2)c1CNc1ccc(C(=O)NCc2cc(F)cc(F)c2)nn1 CHEMBL3908399 IC50 646.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCCCC4)cc3)cn2c1NC(=O)NCc1ccc(Cl)cc1 CHEMBL4870757 IC50 647.0 nM
CCn1cc(C(=O)N/N=C/c2ccc(F)cc2)c2cc(-c3nc(CN4CCC[C@H]4CO)cs3)ccc21 CHEMBL4640212 IC50 655.0 nM
O=C(Nc1ccc(OS(=O)(=O)c2ccc(C(F)(F)F)cc2)cc1)C1CCCC1 CHEMBL4567794 IC50 659.0 nM
O=C(COc1cc(Cl)cc(Cl)c1)N1CCN(c2cccc([N+](=O)[O-])c2)CC1 CHEMBL4543440 IC50 670.0 nM
O=C(Nc1ccc(OS(=O)(=O)c2ccc(C(F)(F)F)cc2)cc1)C1CCCCCCC1 CHEMBL4573280 IC50 679.0 nM
CCn1cc(C(=O)O)c2cc(-c3nc(CN4CCC(O)CC4)cs3)ccc21 CHEMBL4788292 IC50 680.0 nM
O=c1sc(Cc2ccc(OCc3ccc(B(O)O)cc3)cc2)cn1Cc1ccc(F)cc1 CHEMBL1802475 IC50 683.0 nM
Cc1cccc(C(=O)N[C@@H](C(=O)N2CCC3(CC2)C(=O)N(C)C(=O)N3c2ccccc2)C(C)C)c1F CHEMBL4639142 IC50 683.0 nM
CCc1nc2c(C)cc(-c3ccc(CN4CCN(CC)CC4)cc3)cn2c1NC(=O)NCc1ccc(Cl)cc1 CHEMBL4869580 IC50 688.0 nM
CCn1cc(C(=O)O)c(=O)c2cnc(N3CCN(C(=S)Nc4cccc(C(F)(F)F)c4)CC3)nc21 CHEMBL585744 Ki 700.0 nM
O=C1S/C(=C\c2ccc(OCc3ccccc3)cc2)C(=O)N1Cc1ccc(F)cc1 CHEMBL1173237 IC50 700.0 nM
CCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)O)OC CHEMBL2017132 IC50 704.5 nM
CCc1nc2ccc(C3CCN(S(C)(=O)=O)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)cs1 CHEMBL4099513 IC50 710.0 nM
CCn1cc(C(=O)O)c2cc(-c3nc(CN(CO)CO)cs3)ccc21 CHEMBL4777851 IC50 710.0 nM
C[C@H](CCC(=O)N[C@H]1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)C1)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL4098586 IC50 717.0 nM
CCCCCCCC(=O)OC[C@@H](COP(O)(O)=S)OC(=O)CCCCCCC CHEMBL202242 IC50 727.0 nM
O=C(OCc1cc(Cl)cc(Cl)c1)N1CCC(CCNc2c(O)c(=O)c2=O)CC1 CHEMBL3921981 IC50 728.0 nM
O=C(CCCc1c[nH]nn1)NC1CCCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1 CHEMBL3964741 IC50 731.0 nM
CN(C)Cc1csc(-c2ccc3[nH]cc(C(=O)O)c3c2)n1 CHEMBL4636797 IC50 740.0 nM
CCn1cc(NC(=O)OCc2ccccc2)c2cc(-c3nc(CN4CCN(C)CC4)cs3)ccc21 CHEMBL5176364 IC50 753.0 nM
CCn1cc(C(=O)N/N=C/c2ccc3c(c2)OCO3)c2cc(-c3nc(CN4CCN(C)CC4)cs3)ccc21 CHEMBL4645651 IC50 757.0 nM
CCc1nc2ccc(N3CCN(Cc4cnc[nH]4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)cs1 CHEMBL4084600 IC50 771.0 nM
CCn1cc(/C(=N/Nc2nc(-c3ccc(F)cc3)c(C#N)s2)C(F)(F)F)c2cc(-c3nc(CN4CCN(CCO)CC4)cs3)ccc21 CHEMBL4778764 IC50 780.0 nM
CN(CCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)C(=O)c1noc(=O)[nH]1 CHEMBL3910596 IC50 786.0 nM
Cc1nnn(Cc2cc(C(F)(F)F)ccc2/C=C/C(=O)N2CCC(C#N)CC2)n1 CHEMBL4753859 IC50 790.0 nM
O=C(NC1CCCN(C(=O)CCCc2c[nH]nn2)CC1)OCc1cc(Cl)cc(Cl)c1 CHEMBL3974186 IC50 791.0 nM
CCCCCCCCCCCCCCCCCC(=O)OC[C@H]1CCP(=O)([O-])O1 CHEMBL1630083 Ki 800.0 nM
CC(C)Cc1ccc(C(C)C(=O)N2CCC(CCCC3CCN(c4ccc(C(=O)NC(C(N)=O)C(C)O)cn4)CC3)CC2)cc1 CHEMBL2418933 Ki 800.0 nM
C/C=C/C/C=C/C/C=C/CCCCCCCCC1OCC(COP(=O)([O-])O)O1 CHEMBL383362 IC50 803.0 nM
CCc1nc2ccc(C3CCN(S(C)(=O)=O)CC3)cn2c1N(C)c1nc2c(s1)Cc1ccc(F)cc1-2 CHEMBL4080051 IC50 804.0 nM
O=C1C(O)=C(Nc2ccc(C(=O)Nc3ccc4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c4c3)cc2)C(=O)C(O)=C1Nc1ccc(C(=O)Nc2ccc3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c3c2)cc1 CHEMBL1091758 IC50 805.0 nM
CCc1nc2cc(C)c(C3CCN(CC(=O)N4CC(O)C4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)cs1 CHEMBL4069420 IC50 811.0 nM
C[C@H](CCCN1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL4085570 IC50 814.0 nM
Cc1cccc(C(=O)N[C@@H](C(=O)N2CCC3(CC2)C(=O)N(C)CN3C2CC2)C2CCCCC2)c1F CHEMBL4646195 IC50 819.0 nM
CCn1cc(C(=O)O)c2cc(-c3nc(CN4CCOCC4)cs3)ccc21 CHEMBL4788354 IC50 820.0 nM
Cc1cc(-c2ccc(/N=N/c3ccc4c(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c(N)c4c3O)c(C)c2)ccc1/N=N/c1ccc2c(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c(N)c2c1O CHEMBL1200712 Ki 824.0 nM
CN(CCC1CN(C(=O)OCc2cc(Cl)cc(Cl)c2)CCO1)C(=O)c1c[nH]c(=O)o1 CHEMBL3922500 IC50 828.0 nM
O=C(O)CCCC(=O)N1CCc2c(n(Cc3ccccc3)c3ncccc23)C1 CHEMBL4638236 IC50 830.0 nM
CCCCCCC(=O)Nc1ccc(C(F)P(=O)(O)O)cc1 CHEMBL1818153 Ki 834.0 nM
O=C(CCc1nc2cccnc2n1Cc1ccccc1)NCc1cccs1 CHEMBL3928269 IC50 856.0 nM
COC(=O)c1c(F)cc(NC(=O)c2cc(S(=O)(=O)N3CCOCC3)c(Cl)cc2Cl)cc1F CHEMBL4098521 IC50 864.0 nM
CCn1cc(/C(=N/Nc2nc(-c3ccc(OC)cc3)c(C#N)s2)C(F)(F)F)c2cc(-c3nc(CN4CCC[C@H]4CO)cs3)ccc21 CHEMBL4788333 IC50 870.0 nM
CN1CCN(Cc2csc(-c3ccc4c(c3)c(C(=O)N/N=C/c3ccc5c(c3)OCO5)cn4C)n2)CC1 CHEMBL4647615 IC50 879.0 nM
Cc1cc(C)cc(CC(=O)N2CCC(CCCC3CCN(c4ccc(C(=O)NC(C(N)=O)C(C)O)cn4)CC3)CC2)c1 CHEMBL2418935 IC50 900.0 nM
O=C(Nc1c2c(nn1-c1cnccn1)CSC2)c1cccc2ccccc12 CHEMBL5434573 IC50 900.0 nM
Cc1cccc(C(=O)N[C@@H](C(=O)N2CCC3(CC2)C(=O)N(C)CN3c2ccccn2)C2CCCCC2)c1 CHEMBL4636626 IC50 905.0 nM
CCn1cc(C(=O)N/N=C/c2ccc(F)cc2)c2cc(-c3nc(CN4CCC(O)CC4)cs3)ccc21 CHEMBL4643078 IC50 906.0 nM
CCn1cc(/C(=N/Nc2nc(-c3ccc(OC)cc3)c(C#N)s2)C(F)(F)F)c2cc(-c3nc(CN4CC(O)C4)cs3)ccc21 CHEMBL4794345 IC50 910.0 nM
CCn1cc(C(=O)O)c2cc(-c3nc(CN4CCCC4)cs3)ccc21 CHEMBL4759396 IC50 930.0 nM
CCN1CCN(Cc2csc(-c3ccc4c(c3)c(/C(=N/Nc3nc(-c5ccc(OC)cc5)c(C#N)s3)C(F)(F)F)cn4CC)n2)CC1 CHEMBL4780782 IC50 930.0 nM
C[C@H](OC(=O)NCc1nc2cccnc2n1Cc1ccc(F)cc1)c1ccc(F)cc1 CHEMBL3971151 IC50 957.0 nM
CCn1cc(NC(=O)OCc2ccccc2)c2cc(-c3nc(CN4CCC(O)CC4)cs3)ccc21 CHEMBL4641104 IC50 970.0 nM
CCn1cc(/C(=N/Nc2nc(-c3ccc(OC)cc3)c(C#N)s2)C(F)(F)F)c2cc(-c3nc(CN4CCC[C@H]4C(=O)O)cs3)ccc21 CHEMBL4781407 IC50 980.0 nM
CCn1cc(NC(=O)NCc2ccccc2)c2cc(-c3nc(CN4CCC(C)CC4)cs3)ccc21 CHEMBL5175308 IC50 991.0 nM