O=C(Nc1ccc2[nH]ncc2n1)[C@H]1C[C@@H](F)CN1C(=O)C1(c2ccc(Cl)cc2)CC(F)(F)C1 CHEMBL5220994 pIC50 0.07943 nM
O=C(Nc1ccc2[nH]ncc2n1)[C@H]1CCCN1C(=O)C1(c2ccc(Cl)cc2)CCC1 CHEMBL5221053 pIC50 0.1 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCCCc6cccc7c6CN(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5409708 DC50 0.1 nM
CNC(=O)c1ccc(-c2cc3cccc(-c4nn(C5CCOCC5)c5c4CN(C(C)=O)CC5)c3cn2)cn1 CHEMBL4208820 Kd 0.12 nM
O=C(Nc1ccc2[nH]ncc2n1)[C@H]1CCCN1C(=O)C1(c2ccc(F)cc2)CCC1 CHEMBL5219157 pIC50 0.1259 nM
O=C(Nc1ccc2[nH]ncc2n1)[C@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CCCC1 CHEMBL5219693 pIC50 0.1585 nM
O=C(Nc1ccc2[nH]ccc2n1)[C@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CCCC1 CHEMBL5219030 pIC50 0.1585 nM
O=C(Nc1ccc2[nH]ncc2n1)[C@H]1C[C@@H](F)CN1C(=O)C1(c2ccc(Cl)cc2)CCC1 CHEMBL5219667 pIC50 0.1995 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NC6CCN(c7ccc8c(c7)CN(C7CCC(=O)NC7=O)C8=O)CC6)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5413450 EC50 0.2 nM
COc1ccc(C2(C(=O)N3CCC[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CCC2)cc1 CHEMBL5220447 pIC50 0.2512 nM
N#Cc1ccc(C2(C(=O)N3CCC[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CCC2)cc1 CHEMBL5220732 pIC50 0.2512 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5438596 EC50 0.3 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCc6cccc7c6CN(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5418675 DC50 0.3 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCNc6ccc7c(c6)CN(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5413099 DC50 0.3 nM
O=C(Nc1ccc2[nH]ncc2n1)[C@H]1CCCN1C(=O)C1(c2ccc(Cl)cc2)CC(F)(F)C1 CHEMBL5220956 pIC50 0.3162 nM
O=C(Nc1ccc2[nH]c(=O)[nH]c2c1)[C@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CCCC1 CHEMBL5219678 pIC50 0.3981 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C2CC2)C1=O CHEMBL5090239 IC50 0.49 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)c(F)cc3CC[C@H]2C2CC2)C1=O CHEMBL5082755 IC50 0.56 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5439670 EC50 0.6 nM
O=C(Nc1ccc(O)cc1)[C@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CCCC1 CHEMBL5219512 pIC50 0.631 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5412027 EC50 0.7 nM
CNC(=O)c1ccc(NC(=O)[C@H]2CCCN2C(=O)C2(c3cccc(Cl)c3)CCCC2)cc1 CHEMBL5221030 pIC50 0.7943 nM
O=C1Cc2cc(NC(=O)[C@H]3CCCN3C(=O)C3(c4cccc(Cl)c4)CCCC3)ccc2N1 CHEMBL5220546 pIC50 0.7943 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5405240 EC50 0.8 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C2CC2)C1=O CHEMBL4475351 IC50 0.95 nM
O=C(Nc1ccc2[nH]ncc2c1)[C@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CCCC1 CHEMBL5220332 pIC50 1.0 nM
O=C(Nc1ccc2[nH]ncc2n1)[C@H]1COCCN1C(=O)C1(c2ccc(Cl)cc2)CC(F)(F)C1 CHEMBL5219177 pIC50 1.0 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)N6CC7(CC(Nc8cccc9c8C(=O)N(C8CCC(=O)NC8=O)C9=O)C7)C6)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5402691 EC50 1.1 nM
CNC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCOCC2)C1 CHEMBL4097025 IC50 1.2 nM
CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCOCC2)C1 CHEMBL4076748 IC50 1.3 nM
Cn1cc(-c2ccc3c(c2)CC[C@]32NC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C3CC3)C2=O)cn1 CHEMBL4567310 IC50 1.3 nM
COC1CCC(n2c([C@H]3CCCC(=O)N3c3ccc(F)c(F)c3)nc3cc(-c4c(C)noc4C)ccc32)CC1 CHEMBL5409153 Kd 1.3 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCCCCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5406029 EC50 1.6 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)N6CCN(c7cccc8c7C(=O)N(C7CCC(=O)NC7=O)C8=O)CC6)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5405858 EC50 1.6 nM
CNC(=O)Nc1cc2c(cc1F)[C@@]1(CC2)OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C2CC2)C1=O CHEMBL5083020 IC50 1.7 nM
Cn1cc(-c2ccc3c(c2)CC[C@]32NC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C(F)(F)F)C2=O)cn1 CHEMBL4587968 IC50 1.8 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCNc6cccc7c6CN(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5395475 DC50 1.8 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCNc6cccc7c6CN(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5437022 DC50 1.8 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C(F)(F)F)C1=O CHEMBL4457144 IC50 1.9 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NC6CCN(c7ccc8c(c7)C(=O)N(C7CCC(=O)NC7=O)C8=O)CC6)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5397398 EC50 1.9 nM
COc1ccc(NC(=O)[C@H]2CCCN2C(=O)C2(c3cccc(Cl)c3)CCCC2)nc1 CHEMBL5219466 pIC50 1.995 nM
CNC(=O)Nc1ccc2c(c1)CCC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C2CC2)C1=O CHEMBL5077158 IC50 2.2 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCCCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5434991 EC50 2.3 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C(F)(F)F)C1=O CHEMBL4464962 IC50 2.4 nM
Cn1cc(-c2ccc3c(c2)CC[C@@]32OC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C(F)(F)F)C2=O)cn1 CHEMBL4450724 IC50 2.4 nM
Cn1cc(-c2ccc3c(C(=O)[C@H](NCCc4ccc(C#N)cc4)c4ccccc4)c[nH]c3c2)cn1 CHEMBL4633516 IC50 2.5 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccccc3CC[C@H]2C)C1=O CHEMBL4524352 IC50 2.5 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccccc3CC[C@H]2C(F)(F)F)C1=O CHEMBL4449592 IC50 2.6 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C)C1=O CHEMBL4452911 IC50 3.0 nM
CC(=O)N[C@@H](CCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)(O)O)C(N)=O CHEMBL505121 IC50 3.2 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccccc3CC[C@H]2C2CC2)C1=O CHEMBL4552724 IC50 3.7 nM
CCC[C@@H]1CCc2ccccc2CN1C(=O)CN1C(=O)O[C@@]2(CCc3cc(NC(=O)NC)ccc32)C1=O CHEMBL4474031 IC50 4.0 nM
Cn1cc(-c2ccc3c(c2)CC[C@@]32OC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C3CC3)C2=O)cn1 CHEMBL4474109 IC50 4.0 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3sccc3OC[C@H]2C2CC2)C1=O CHEMBL5094423 IC50 4.0 nM
CNC(=O)Nc1ccc2c(c1)CC[C@]21NC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C2CC2)C1=O CHEMBL4449940 IC50 4.2 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccccc3CC[C@H]2C(C)C)C1=O CHEMBL4593536 IC50 4.3 nM
COc1ccc(NC(=O)[C@H]2CCCCN2C(=O)C2(c3ccc(Cl)cc3)CCCC2)cc1 CHEMBL5221088 pIC50 5.012 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCNc6ccc7c(c6)CN(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5419387 DC50 5.1 nM
CNC(=O)Nc1ccc2c(c1)CC[C@]21NC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C(F)(F)F)C1=O CHEMBL4439084 IC50 7.5 nM
COc1ccc(NC(=O)[C@H]2CCCN2C(=O)C2(c3ccc(Cl)cc3)CCCC2)cc1 CHEMBL5219851 pIC50 7.943 nM
C[C@H](CN[C@@H](C(=O)Nc1ccc(-c2cnn(C)c2)cn1)c1ccccc1)c1ccc(C#N)cc1 CHEMBL4641354 IC50 8.1 nM
CNC(=O)Nc1ccc2c(c1)OCC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C2CC2)C1=O CHEMBL5081689 IC50 8.6 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ncccc3CC[C@H]2C2CC2)C1=O CHEMBL5078353 IC50 8.6 nM
CCNC(=O)c1ccc2c(C(=O)[C@H](NC[C@@H](C)c3ccc(C#N)cc3)c3ccccc3)c[nH]c2c1 CHEMBL4794518 IC50 8.8 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)N6CCC7(CC6)CC(Nc6cccc8c6C(=O)N(C6CCC(=O)NC6=O)C8=O)C7)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5429111 EC50 9.3 nM
CC1=NN(c2ccc(C(=O)O)cc2)C(=O)/C1=C/c1ccc(-c2cc(C)c(C)cc2[N+](=O)[O-])o1 CHEMBL3734823 IC50 9.8 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N(Cc2ccc(F)cc2)[C@@H](C)C(F)(F)F)C1=O CHEMBL4282264 IC50 9.8 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccncc3CC[C@H]2C2CC2)C1=O CHEMBL5078021 IC50 9.8 nM
CNC(=O)Nc1ccc2c(c1)CC[C@]21OC(=O)N(CC(=O)N2Cc3ccccc3CC[C@H]2C(F)(F)F)C1=O CHEMBL4513653 IC50 10.0 nM
Cn1cc(-c2cnc3c(c2)CC[C@]32NC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C(F)(F)F)C2=O)cn1 CHEMBL4456527 IC50 10.0 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cccnc3CC[C@H]2C2CC2)C1=O CHEMBL5085891 IC50 10.0 nM
COc1ccc(NC(=O)[C@H]2CCCN2C(=O)C2(c3ccc(Cl)cc3)CCC2)cc1 CHEMBL5218875 pIC50 10.0 nM
CNC(=O)c1cccc(CNC(=O)[C@H]2CCCN2C(=O)C2(c3ccc(Cl)cc3)CCCC2)c1 CHEMBL5219712 pIC50 10.0 nM
N=C(N)NCCC[C@@H]1NC(=O)/C(=C/c2ccc(O)c(OCC[C@H](NC(=O)C[C@](O)(CC(=O)N[C@@H](CC(=O)O)C(=O)O)C(=O)O)C(=O)O)c2)NC1=O CHEMBL3774787 IC50 11.0 nM
N=C(N)NCCC[C@@H]1NC(=O)/C(=C\c2ccc(O)c(OCC[C@H](NC(=O)C[C@](O)(CC(=O)N[C@@H](CC(=O)O)C(=O)O)C(=O)O)C(=O)O)c2)NC1=O CHEMBL4524766 IC50 11.0 nM
CNC(=O)Nc1ccc2c(c1)CCC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C2CC2)C1=O CHEMBL5083262 IC50 11.0 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccccc3OC[C@H]2C)C1=O CHEMBL4584269 IC50 12.0 nM
CNC(=O)Nc1ccc2c(c1)COC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C2CC2)C1=O CHEMBL5073432 IC50 12.0 nM
O=C(Nc1ccc2[nH]ncc2n1)[C@H]1C[C@@H](F)CN1C(=O)C1(c2ccc(O)cc2)CCCCC1 CHEMBL5405877 IC50 12.0 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cnccc3CC[C@H]2C2CC2)C1=O CHEMBL5084035 IC50 13.0 nM
COc1ccc(C(C)(C)C(=O)N2C[C@H](F)C[C@@H]2C(=O)Nc2ccc3[nH]ncc3n2)cc1 CHEMBL5413801 IC50 13.0 nM
Cn1cc(-c2ccc3c(n2)CC[C@]32NC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C(F)(F)F)C2=O)cn1 CHEMBL4441280 IC50 14.0 nM
COc1ccc(C2(C(=O)N3C[C@H](F)C[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CCCCC2)cc1F CHEMBL5428296 IC50 14.0 nM
COc1ccc(C2(C(=O)N3C[C@H](F)C[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CCCCC2)cn1 CHEMBL5428708 IC50 15.0 nM
O=C(Nc1cnc2[nH]ncc2c1)[C@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CCCC1 CHEMBL5219204 pIC50 15.85 nM
CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CO)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)O)C(C)C CHEMBL4593074 Kd 16.0 nM
Cn1cc(-c2ccc3c(C(=O)[C@H](NCCc4ccc(C#N)cc4)c4ccccc4)cnn3c2)cn1 CHEMBL4648384 IC50 17.0 nM
Cn1cc(-c2ccc(NC(=O)[C@H](NCCc3ccc(C#N)cc3)c3ccccc3)nc2)cn1 CHEMBL4636118 IC50 19.0 nM
COc1ccc(NC(=O)[C@H]2CCCN2C(=O)C2(c3ccc(Cl)cc3)CCCCC2)cc1 CHEMBL5221117 pIC50 19.95 nM
O=C(Nc1ccc2[nH]nnc2c1)[C@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CCCC1 CHEMBL5219472 pIC50 19.95 nM
COc1ccc(C2(C(=O)N3C[C@H](F)C[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CC(F)(F)C2)cc1 CHEMBL5437515 IC50 20.0 nM
Cn1cc(-c2ccc3c(c2)CCN3C(=O)[C@H](NCCc2ccc(C#N)cc2)c2ccccc2)cn1 CHEMBL4643833 IC50 21.0 nM
COc1ccc(C2(C(=O)N3C[C@H](F)C[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CCCCC2)cc1 CHEMBL5401710 IC50 21.0 nM
O=C(Nc1ccc2[nH]ncc2n1)[C@H]1C[C@@H](F)CN1C(=O)C1(c2ccc(C(=O)C(F)(F)F)cc2)CCCCC1 CHEMBL5433934 IC50 21.0 nM
N=C(N)NCCC[C@@H]1NC(=O)/C(=C/c2ccc(O)c(OCC[C@H](NC(=O)C[C@](O)(CC(=O)O)C(=O)O)C(=O)O)c2)NC1=O CHEMBL3774491 IC50 22.0 nM
N=C(N)NCCC[C@@H]1NC(=O)/C(=C\c2ccc(O)c(OCC[C@H](NC(=O)C[C@](O)(CC(=O)O)C(=O)O)C(=O)O)c2)NC1=O CHEMBL4447371 IC50 22.0 nM
COc1ccc(C2(C(=O)N3CS(=O)(=O)C[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CCCCC2)cc1 CHEMBL5402558 IC50 22.0 nM
COc1ccc(C2(C(=O)N3CCC[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CCCC2)cc1 CHEMBL5410953 IC50 24.0 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)N6CC7(CCC(Nc8cccc9c8C(=O)N(C8CCC(=O)NC8=O)C9=O)CC7)C6)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5405265 EC50 25.0 nM
COc1ccc(C2(C(=O)N3C[C@H](F)C[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CCC(F)(F)CC2)cc1 CHEMBL5438086 IC50 28.0 nM
CC(=O)N1CCc2c(c(Nc3ccc(-c4cnn(C)c4)cc3F)nn2[C@@H]2CCOC2)C1 CHEMBL3968533 IC50 30.0 nM
Cn1cc(-c2cc3c(cn2)[C@]2(CC3)NC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C(F)(F)F)C2=O)cn1 CHEMBL4519167 IC50 30.0 nM
Cc1cc(-c2ccc3nc(C4CCOCC4)n(CCOC(F)(F)F)c3c2)cn(C)c1=O CHEMBL5274024 Kd 31.0 nM
COc1ccc(C2(C(=O)N3C[C@H](F)C[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CCOCC2)cc1 CHEMBL5417505 IC50 31.0 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2C[C@H](C)N2CCOCC2)cc1Cl CHEMBL3622373 Kd 32.0 nM
COCCNC(=O)CCCCn1cc(-c2ccc(NC(=O)C(NCC(C)c3ccc(C#N)cc3)c3ccccc3)nc2)cn1 CHEMBL5413122 IC50 35.0 nM
Cn1cc(-c2ccc3c(C(=O)[C@H](NCCc4ccc(C#N)cc4)c4ccccc4)c[nH]c3n2)cn1 CHEMBL4640553 IC50 36.0 nM
COc1ccc(C2(C(=O)N3C[C@H](F)C[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CCC(F)(F)CC2)cc1F CHEMBL5406285 IC50 36.0 nM
CCS(=O)(=O)Nc1cc(-c2cn(C)c3c(=O)[nH]ccc23)cc2c1ccn2C(C)(c1ccccn1)c1ccccn1 CHEMBL4648912 Kd 37.0 nM
COc1ccc(NC(=O)[C@H]2CCN2C(=O)C2(c3ccc(Cl)cc3)CCCC2)cc1 CHEMBL5218882 pIC50 39.81 nM
CNC(=O)Nc1ccc2c(c1)CC[C@]21OC(=O)N(CC(=O)N2Cc3ccccc3CC[C@H]2C)C1=O CHEMBL4472048 IC50 46.0 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2[C@H]2CC[C@H](O)CC2)cc1Cl CHEMBL5186832 IC50 48.0 nM
COc1ccc2c(Cc3nc4cc(-c5c(C)noc5C)ccc4n3[C@H]3CC[C@H](O)CC3)cc(=O)oc2c1 CHEMBL5183932 IC50 48.0 nM
COc1ccc(C2(C(=O)N3C[C@H](F)C[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CC(C)(C)C2)cc1 CHEMBL5421236 IC50 48.0 nM
COc1ccc2c(c1)c(C(=O)Nc1cc(C(=O)O)cc(-c3cnn(C)c3)c1F)cn2C(C)=O CHEMBL4171749 IC50 49.0 nM
COc1ccc(N2C(=O)C[C@H]2c2nc3cc(-c4c(C)noc4C)ccc3n2[C@H]2CC[C@H](OC)CC2)cc1Cl CHEMBL5177205 IC50 49.0 nM
COc1ccc(C2(C(=O)N3CCOCC(Cc4cccc5[nH]ncc45)C3)CCCC2)cc1 CHEMBL5174606 IC50 50.0 nM
COc1ccc(C2(C(=O)N3C[C@H](O)C[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CCCCC2)cc1 CHEMBL5435603 IC50 50.0 nM
COc1ccc(NC(=O)[C@H]2CCCN2C(=O)C(C)(C)c2ccc(Cl)cc2)cc1 CHEMBL5220135 pIC50 50.12 nM
C[C@@H]1CC(=O)Nc2cccc(-c3ccc4c(c3)c(-c3cnn(C)c3)nn4C)c2N1 CHEMBL3814752 IC50 51.0 nM
CCOCCNC(=O)CCCn1cc(-c2ccc(NC(=O)C(NCC(C)c3ccc(C#N)cc3)c3ccccc3)nc2)cn1 CHEMBL5405272 IC50 52.0 nM
CS(=O)(=O)c1ccc(C2(C(=O)N3C[C@H](F)C[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CCC(F)(F)CC2)cc1 CHEMBL5402105 IC50 55.0 nM
COc1ccc(C2(C(=O)N3C[C@H](F)C[C@@H]3C(=O)Nc3cccc4[nH]ncc34)CCCC2)cc1 CHEMBL5193437 IC50 56.0 nM
COc1ccc(C2(C(=O)N3CCC[C@@H]3C(=O)Nc3cccc4[nH]ccc34)CCCC2)cc1 CHEMBL5431026 IC50 61.0 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3987016 IC50 63.0 nM
CC(C)(C)OC(=O)NCCCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)(O)O CHEMBL3775655 IC50 70.0 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21NC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C2CC2)C1=O CHEMBL4582713 IC50 73.0 nM
COc1c(F)cc(C2(C(=O)N3C[C@H](F)C[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CCC(F)(F)CC2)cc1F CHEMBL5432898 IC50 76.0 nM
COc1ccc(NC(=O)[C@H]2CCCN2C(=O)C2(c3ccccc3)CCCC2)cc1 CHEMBL5218485 pIC50 79.43 nM
COc1ccc(N2C(=O)C[C@@H]2c2nc3cc(-c4c(C)noc4C)ccc3n2[C@H]2CC[C@H](OC)CC2)cc1Cl CHEMBL5189469 IC50 81.0 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2C2CCC(F)(F)CC2)cc1Cl CHEMBL5192241 IC50 83.0 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2C2CCN(C(C)=O)CC2)cc1Cl CHEMBL5192591 IC50 94.0 nM
Cn1cc(-c2ccn3c(C(=O)[C@H](NCCc4ccc(C#N)cc4)c4ccccc4)cnc3c2)cn1 CHEMBL4639768 IC50 97.0 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2[C@H]2CC[C@H](OC)CC2)cc1Cl CHEMBL5193321 IC50 97.0 nM
COc1ccc(NC(=O)[C@H]2CCCN2C(=O)C2(c3cccc(Cl)c3)CCCC2)cc1 CHEMBL5219575 pIC50 100.0 nM
O=C1C(Cc2ccccc2)C(=O)N(Cc2ccccc2)C(=O)N1Cc1ccccc1 CHEMBL3421930 Kd 110.0 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(C4CC4)nn3C)c12 CHEMBL4173488 Kd 110.0 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2C2CC(C)(C)OC(C)(C)C2)cc1Cl CHEMBL5207333 IC50 112.0 nM
Cn1cc(-c2ccc(NC(=O)[C@H](NCCc3ccc(C#N)cc3)c3ccccc3)cc2)cn1 CHEMBL4636245 IC50 120.0 nM
CCOCCNC(=O)CCn1cc(-c2ccc(NC(=O)C(NCC(C)c3ccc(C#N)cc3)c3ccccc3)nc2)cn1 CHEMBL5439045 IC50 123.0 nM
COc1ccc(C2(C(=O)N3CCOCC(Cc4cccc5[nH]ncc45)C3)CCCCC2)cc1 CHEMBL5177811 IC50 140.0 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2C2CCN(S(C)(=O)=O)CC2)cc1Cl CHEMBL5179411 IC50 148.0 nM
COc1ccc(C2(C(=O)N3CS(=O)(=O)C[C@@H]3C(=O)Nc3cccc4[nH]ncc34)CCCC2)cc1 CHEMBL5193672 IC50 150.0 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2[C@H]2C[C@H](O)C2)cc1Cl CHEMBL5199445 IC50 155.0 nM
COc1ccc(NC(=O)CN(C)C(=O)C2(c3ccccc3)CCCC2)cc1 CHEMBL1700017 pIC50 158.49 nM
Cc1cc(-c2ccc(/C=C3\C(=O)N(c4ccc(C(=O)O)cc4)N=C3C3CC3)s2)c(C(F)(F)F)cc1C CHEMBL4461759 IC50 160.0 nM
CCC(=O)N1CCOc2c(cc(-c3ccc(OC)c(OC)c3)cc2OC[C@H]2CCCN(C)C2)C1 CHEMBL3774655 Kd 167.0 nM
COc1ccc(C2(C(=O)N3CCC[C@@H]3C(=O)Nc3cccc4[nH]ncc34)CCCCC2)cc1 CHEMBL5184238 IC50 167.0 nM
COc1ccc(C2(C(=O)N3CCC[C@@H]3C(=O)Nc3cccc4[nH]ncc34)CCCC2)cc1 CHEMBL5178312 IC50 176.0 nM
CCC1=NN(c2ccc(C(=O)O)cc2)C(=O)/C1=C\c1ccc(-c2cc(C)c(C)cc2[N+](=O)[O-])o1 CHEMBL4515273 IC50 190.0 nM
COc1ccc(C2(C(=O)N(C)CC(=O)Nc3cccc4[nH]ncc34)CCCCC2)cc1 CHEMBL5187549 IC50 190.0 nM
CC1=NN(c2ccc(C(=O)O)cc2)C(=O)/C1=C\c1ccc(-c2cc(C)c(C)cc2[N+](=O)[O-])o1 CHEMBL1797936 IC50 191.0 nM
Cc1cc(-c2ccc(/C=C3\C(=O)N(c4ccc(C(=O)O)cc4)N=C3C3CC3)o2)c([N+](=O)[O-])cc1C CHEMBL4452725 IC50 200.0 nM
COc1ccc(C2(C(=O)N3CCC[C@@H]3C(=O)Nc3ccc4[nH]ccc4c3)CCCC2)cc1 CHEMBL5410098 IC50 213.0 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NC2CCCCC2)cc1Cl CHEMBL4853072 Kd 215.0 nM
Cc1ccc2ncccc2c1-c1cc(-c2c(C)noc2C)cc2nc(C3CC3)[nH]c12 CHEMBL3926851 Kd 220.0 nM
COc1ccc(C2(C(=O)N(C)[C@H](C)C(=O)Nc3cccc4[nH]ncc34)CCCC2)cc1 CHEMBL5191305 IC50 220.0 nM
CC1=NN(c2ccc(C(=O)O)cc2)C(=O)/C1=C\c1ccc(-c2cc(C)c(C)cc2[N+](=O)[O-])s1 CHEMBL4449504 IC50 230.0 nM
COc1ccc2c(c1)N(CCC/C=C/c1cccc3c1N[C@H](C)CC(=O)N3)CCC2 CHEMBL5089448 Kd 240.0 nM
COc1ccc(C2(C(=O)N3CCC[C@@H]3C(=O)Nc3ccc4[nH]ncc4c3)CCCC2)cc1 CHEMBL5419301 IC50 254.0 nM
CCN(CC)c1ccc2c(C)c(-c3ccc(N4C(=O)C=CC4=O)cc3)c(=O)oc2c1 CHEMBL3416552 IC50 260.0 nM
COc1ccc(C2(C(=O)N3C[C@H](O)C[C@@H]3C(=O)Nc3cccc4[nH]ncc34)CCCC2)cc1 CHEMBL5207535 IC50 260.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc(C1CC1c1ccccc1)n2[C@H]1CC[C@H](O)CC1 CHEMBL5180576 IC50 263.0 nM
CN(C)C(=O)c1cccc(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL4436408 IC50 270.0 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NC2CCCCC2)cc1 CHEMBL4867046 Kd 285.0 nM
CC1=NN(c2ccc(C(=O)O)cc2)C(=O)/C1=C\c1ccc(-c2cc(C)c(C)cc2C(F)(F)F)o1 CHEMBL4436898 IC50 290.0 nM
O=C(O)CSc1cc(NS(=O)(=O)c2ccc(Br)cc2)c2ccccc2c1O CHEMBL1331211 IC50 330.0 nM
COc1ccc(S(=O)(=O)N(Cc2ccc3c(c2)C=CC(C)(C)O3)c2ccccc2)cc1OC CHEMBL1823895 Kd 345.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccccc1)n2CCN1CCOCC1 CHEMBL3753333 Kd 350.0 nM
CC1=NN(c2ccc(C(=O)O)cc2)C(=O)C1=Cc1ccc(-c2cc(C)c(C)cc2[N+](=O)[O-])o1 CHEMBL4208500 Ki 400.0 nM
COc1cc2c(cc1OC)-c1cc3ccc(OC)c(OC)c3c[n+]1CCC2 CHEMBL4573224 IC50 420.0 nM
COc1cc2c(cc1OC)-c1cc3cc(OC)c(OC)cc3c[n+]1CCC2 CHEMBL4457203 IC50 420.0 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3sc(C)c(C)c3OC[C@H]2C(F)(F)F)C1=O CHEMBL5089370 IC50 430.0 nM
Cn1cc(-c2cnc(NC(=O)[C@H](NCCc3ccc(C#N)cc3)c3ccccc3)cn2)cn1 CHEMBL4639561 IC50 460.0 nM
CC1=NN(c2ccc(P(=O)(O)O)cc2)C(=O)/C1=C\c1ccc(-c2cc(C)c(C)cc2[N+](=O)[O-])o1 CHEMBL4448489 IC50 470.0 nM
CCc1c(C(=O)NCc2c(O)ccc3cccc(O)c23)[nH]c(C)c1C(C)=O CHEMBL4741587 Kd 470.0 nM
CCC1C(C(=O)NCc2c(O)ccc3cccc(O)c23)NC(C)C1C(C)=O CHEMBL5394573 Kd 470.0 nM
C=C(C)[C@H](CC=C(C)C)C[C@]12C[C@H](CC=C(C)C)C(C)(C)[C@](CC=C(C)C)(C(=O)C(C(=O)c3ccc(O)c(O)c3)=C1O)C2=O CHEMBL445599 IC50 500.0 nM
CC(=O)N[C@@H](CCCCNC(=O)CSCCNC(=O)[C@H](O)CCOP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3cncnc32)[C@H](O)[C@@H]1OP(=O)(O)O)C(N)=O CHEMBL4789343 IC50 500.0 nM
COc1ccc(C2(C(=O)N3CCC[C@@H]3C(=O)Nc3ccc4cn[nH]c4c3)CCCC2)cc1 CHEMBL5413514 IC50 500.0 nM
O=S(=O)(Nc1cc(Sc2ncn[nH]2)c(O)c2ccccc12)c1ccc2ccccc2c1 CHEMBL2030281 IC50 510.0 nM
COc1ccc2c(c1)c(C(=O)Nc1cc(C(=O)O)cc(-c3cnn(C)c3)c1)cn2C(C)=O CHEMBL4163872 IC50 510.0 nM
Cc1nc(C(=O)[C@H](NCCc2ccc(C#N)cc2)c2ccccc2)c2ccc(-c3cnn(C)c3)cn12 CHEMBL4636484 IC50 520.0 nM
CC(C)C[C@@H]1NCCN([C@@H](CC(C)C)C(=O)N2CCN([C@@H](CCC(N)=O)C(N)=O)C(=O)[C@@H]2C)C1=O CHEMBL4466328 Kd 530.0 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3ccnc4ccccc34)c12 CHEMBL4171228 Kd 550.0 nM
CC1=NN(c2ccc(C(=O)O)cc2)C(=O)/C1=C\c1ccc(-c2ccccc2[N+](=O)[O-])o1 CHEMBL4452893 IC50 560.0 nM
Cn1cc(-c2ccc3c(C(=O)C(NCCc4ccc(C#N)cc4)c4ccccc4)n[nH]c3c2)cn1 CHEMBL4648100 IC50 570.0 nM
CC1=NN(c2ccc(C(=O)O)cc2)C(=O)/C1=C\c1ccc(-c2cccc3c2C(=O)CC3)o1 CHEMBL4474848 IC50 580.0 nM
COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cccc(OC)c5c4CCN3C[C@H]2CC[C@H]1O CHEMBL4752387 IC50 580.0 nM
COc1ccc(C2(C(=O)N3CCOCC(Cc4cccc5[nH]ncc45)C3)CCOCC2)cc1 CHEMBL5209027 IC50 610.0 nM
CC(C)(C)c1ccc(-c2cc(CNCC3CCNCC3)sc2-c2ccc(C(C)(C)C)cc2)cc1 CHEMBL4474132 IC50 620.0 nM
O=C(O)CSc1cc(NS(=O)(=O)c2ccc(C(=O)O)cc2)c2ccccc2c1O CHEMBL2031566 IC50 660.0 nM
CC1=NN(c2ccc(-c3nn[nH]n3)cc2)C(=O)/C1=C\c1ccc(-c2cc(C)c(C)cc2[N+](=O)[O-])o1 CHEMBL4526489 IC50 670.0 nM
CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)N1CC/C=C\CC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C1=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(N)=O CHEMBL4435255 Kd 690.0 nM
CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)N1C/C=C/CCN[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C1=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(N)=O CHEMBL4524475 Kd 690.0 nM
COc1cc2c(cc1OC)C1Cc3cc(O)c(O)cc3NC1CC2 CHEMBL4759868 IC50 690.0 nM
Cc1ccc(N2C(=O)/C(=C\C=C\c3ccco3)C(=O)NC2=S)cc1Cl CHEMBL4277102 IC50 700.0 nM
Cc1ccc(N2C(=O)/C(=C/C=C/c3ccco3)C(=O)NC2=S)cc1Cl CHEMBL4520444 IC50 700.0 nM
CCCCC[C@H](O)C/C=C1/C(=O)C=C[C@@H]1C/C=C/CCCC(=O)O CHEMBL4579084 IC50 750.0 nM
CN1C(=O)[C@@]2(Cc3ccc(C[C@]45SS[C@](CO)(C(=O)N4C)N(C)C5=O)cc3)SS[C@]1(CO)C(=O)N2C CHEMBL4555191 Kd 750.0 nM
Cn1cc(-c2ccc(NC(=O)[C@H](NCCc3ccc(C#N)cc3)c3ccccc3)nn2)cn1 CHEMBL4642909 IC50 770.0 nM
CCn1cc(-c2cccc(C(F)(F)F)c2)c2sc(C(=N)NC3CCS(=O)(=O)CC3)cc2c1=O CHEMBL3769507 Kd 770.0 nM
CC1=NN(c2ccc(C(=O)O)cc2)C(=O)/C1=C\c1cnc(-c2cc(C)c(C)cc2[N+](=O)[O-])s1 CHEMBL4449804 IC50 860.0 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2[C@H]2CC[C@H](C(F)(F)F)CC2)cc1Cl CHEMBL5177457 IC50 894.0 nM
COc1ccc(C2(C(=O)N3C[C@@H](O)C[C@@H]3C(=O)Nc3cccc4[nH]ncc34)CCCC2)cc1 CHEMBL5180471 IC50 910.0 nM
CC(=O)n1cc(C(=O)Nc2cc(C(=O)O)cc(-c3ccco3)c2)c2ccccc21 CHEMBL4159164 IC50 970.0 nM
O=C(O)CCSc1cc(NS(=O)(=O)c2ccc(Br)cc2)c2ccccc2c1O CHEMBL3416536 IC50 1000.0 nM