CCC(C)C(=O)N1CCC(NC(=O)Nc2ccc(C(F)(C(F)(F)F)C(F)(F)F)cc2)CC1 CHEMBL3327073 Ki 0.02 nM
CNc1nc(C)nc(N[C@H]2CCC[C@@H](C(=O)NCc3ccc(C#N)cc3C(F)(F)F)C2)n1 CHEMBL3818875 IC50 0.027 nM
Cc1cc(C(=O)Nc2ccc(Cl)cc2)ccc1N(CCN1CCCC1)C(=O)Nc1ccc(Cl)cc1 CHEMBL5190894 IC50 0.03 nM
CCC(=O)N1CCCN(C(=O)C2CCCN(Cc3ccc(NC(=O)N[C@@]45C[C@@H]6C[C@@](C)(C[C@@](C)(C6)C4)C5)c(F)c3)C2)CC1 CHEMBL5425833 IC50 0.05 nM
O=C(Nc1ccc(C(F)(F)F)c(F)c1)NC1CCN(C(=O)C2(C(F)(F)F)CC2)CC1 CHEMBL4752831 Ki 0.08 nM
O=C(Cc1ccccc1)Nc1nc2ccc(N(CCN3CCOCC3)C(=O)Nc3ccc(Cl)cc3)cc2s1 CHEMBL4745610 IC50 0.082 nM
O=C(NCc1ccc(Br)cc1OC(F)(F)F)c1ccc(OCCC(F)(F)F)nc1 CHEMBL566648 IC50 0.1 nM
O=C(Nc1ccc(Cl)cc1)Nc1nc2ccc(N(CCN3CCOCC3)C(=O)Nc3ccc(Cl)cc3)cc2s1 CHEMBL4781218 IC50 0.1 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCCC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1 CHEMBL3104615 IC50 0.125 nM
CS(=O)(=O)c1ccc([C@@H](CCNC(=O)c2ccc(C#N)cc2)c2ccc(F)cc2)cc1 CHEMBL556717 EC50 0.14 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(CN4CCCC(C(N)=O)C4)cc1F)(C3)C2 CHEMBL5428998 IC50 0.14 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(CN4CCCC(C(=O)NC(CO)(CO)CO)C4)cc1F)(C3)C2 CHEMBL5403016 IC50 0.14 nM
O=C(Nc1ccc(OC(F)(F)F)c(F)c1)NC1CCN(C(=O)C2CC2)CC1 CHEMBL4748112 Ki 0.15 nM
CC[C@H](C)C(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1 CHEMBL3327078 Ki 0.19 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3cc(O)ccc3F)CC2)C1 CHEMBL2436573 IC50 0.2 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3cccc4ncccc34)CC2)C1 CHEMBL2436575 IC50 0.2 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3cnoc3C3CC3)CC2)C1 CHEMBL2436579 IC50 0.2 nM
CC[C@H](C)C(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1 CHEMBL3327067 Ki 0.22 nM
Cc1ccoc1C(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1 CHEMBL4781745 Ki 0.22 nM
CCC(C)C(=O)N1CCC(NC(=O)N[C@H]2CC[C@H](CC)CC2)CC1 CHEMBL3325465 Ki 0.23 nM
CS(=O)(=O)c1cccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c1 CHEMBL592741 EC50 0.25 nM
Nc1nc2ccc(N(CCN3CCOCC3)C(=O)Nc3ccc(F)c(Br)c3)cc2s1 CHEMBL4759847 IC50 0.25 nM
CCC(C)C(=O)N1CCCN(C(=O)C2CCCN(Cc3ccc(NC(=O)N[C@@]45C[C@@H]6C[C@@](C)(C[C@@](C)(C6)C4)C5)c(F)c3)C2)CC1 CHEMBL5435879 IC50 0.25 nM
Cc1ccoc1C(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1 CHEMBL4764213 Ki 0.26 nM
CC(O)CNC(=O)C1CCCN(C(=O)c2ccc(NC(=O)N[C@]34C[C@@H]5C[C@@](C)(C[C@@](C)(C5)C3)C4)c(F)c2)C1 CHEMBL5430146 IC50 0.28 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1 CHEMBL2397148 IC50 0.28 nM
CC(O)CNC(=O)C1CCCN(Cc2ccc(NC(=O)N[C@@]34C[C@@H]5C[C@@](C)(C[C@@](C)(C5)C3)C4)c(F)c2)C1 CHEMBL5406085 IC50 0.28 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(CN4CCCC(C(=O)N(CCO)CCO)C4)cc1F)(C3)C2 CHEMBL5429256 IC50 0.28 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(CN4CCCC(C(=O)NC(CO)CO)C4)cc1F)(C3)C2 CHEMBL5417008 IC50 0.28 nM
CNS(=O)(=O)c1ccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1 CHEMBL589138 EC50 0.29 nM
CS(=O)(=O)c1ccc(C(CCNC(=O)c2ccc(OCC(F)(F)F)nc2)c2ccc(F)cc2)cc1 CHEMBL556234 EC50 0.3 nM
CS(=O)(=O)c1ccc(C(CCNC(=O)c2ccc(C#N)cc2)c2ccc(F)cc2)cc1 CHEMBL556716 EC50 0.3 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1 CHEMBL2436563 IC50 0.3 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3ccccc3Cl)CC2)C1 CHEMBL2436574 IC50 0.3 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)C3(C(F)(F)F)CC3)CC2)C1 CHEMBL2436586 IC50 0.3 nM
CCC(CC)C(=O)N1CCC2(CCN(C(=O)Nc3ccc(OC(F)(F)F)cc3)C2)CC1 CHEMBL2436591 IC50 0.3 nM
Cc1cc(C(=O)Nc2ccc(Cl)cc2)ccc1N(CCN1CCOCC1=O)C(=O)Nc1ccc(Cl)cc1 CHEMBL5170467 IC50 0.3 nM
Cc1cc(C(=O)Nc2ccc3c(c2)OCO3)ccc1N(CCN1CCCC1=O)C(=O)Nc1ccc(Cl)cc1 CHEMBL5199526 IC50 0.3 nM
CC(C)C(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1 CHEMBL3327077 Ki 0.31 nM
CC(C)C(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)c(F)c2)CC1 CHEMBL4743434 Ki 0.31 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)c2ccoc2)CC1 CHEMBL4752121 Ki 0.33 nM
CCC(=O)N1CCC(CC(=O)N2CCCN(Cc3ccc(NC(=O)N[C@@]45C[C@@H]6C[C@@](C)(C[C@@](C)(C6)C4)C5)c(F)c3)CC2)CC1 CHEMBL5427173 IC50 0.33 nM
CNC(=O)c1ccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1 CHEMBL592743 EC50 0.34 nM
O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL215387 IC50 0.35 nM
CCN(CC)C(=O)C1CCCN(C(=O)c2ccc(NC(=O)N[C@]34C[C@@H]5C[C@@](C)(C[C@@](C)(C5)C3)C4)c(F)c2)C1 CHEMBL5431392 IC50 0.35 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@](NC(=O)Nc1ccc(C(=O)N4CCCC(C(=O)NCCO)C4)cc1F)(C3)C2 CHEMBL5405764 IC50 0.35 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(C(=O)NC4CCC(C(=O)NC(CO)(CO)CO)CC4)cc1F)(C3)C2 CHEMBL5424246 IC50 0.35 nM
CCN(CC)C(=O)C1CCCN(Cc2ccc(NC(=O)N[C@@]34C[C@@H]5C[C@@](C)(C[C@@](C)(C5)C3)C4)c(F)c2)C1 CHEMBL5434178 IC50 0.35 nM
CCC(C)C(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1 CHEMBL3327074 Ki 0.36 nM
CCC(C)C(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1 CHEMBL3327066 Ki 0.37 nM
CC[C@H](C)C(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)c(F)c2)CC1 CHEMBL4741174 Ki 0.37 nM
O=C(Nc1ccc(C(F)(F)F)c(F)c1)NC1CCN(C(=O)C2CC2)CC1 CHEMBL4756077 Ki 0.38 nM
CCOC(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)c(F)c2)CC1 CHEMBL4780369 Ki 0.38 nM
CS(=O)(=O)c1ccc(C(=O)NCCC(c2ccc(F)cc2)c2ccc(S(C)(=O)=O)cc2)cc1 CHEMBL562081 EC50 0.4 nM
CCC(=O)N1CCC(NC(=O)Nc2cc(Cl)cc(Cl)c2)CC1 CHEMBL1258558 IC50 0.4 nM
CCC(=O)N1CCC(NC(=O)Nc2ccc(C(F)(C(F)(F)F)C(F)(F)F)cc2)CC1 CHEMBL1258785 IC50 0.4 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)C2CC2)CC1 CHEMBL1257405 IC50 0.4 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)C(F)(F)F)CC1 CHEMBL1257517 IC50 0.4 nM
CCS(=O)(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1 CHEMBL1257635 IC50 0.4 nM
Cc1ccc(S(=O)(=O)N2CCC(NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1 CHEMBL1257759 IC50 0.4 nM
O=C(Nc1cccc(C(F)(F)F)c1F)NC1CCCCCCC1 CHEMBL1818408 IC50 0.4 nM
CCCCCCCNC(=O)Nc1cccc(C(F)(F)F)c1F CHEMBL1818407 IC50 0.4 nM
Cc1ccc(NC(=O)NC2CCCCCCC2)cc1Cl CHEMBL1818404 IC50 0.4 nM
Cc1ccc(NC(=O)NCC23CC4CC(CC(C4)C2)C3)cc1Cl CHEMBL1817677 IC50 0.4 nM
O=C(NC1CCCCC1)NC1C2CC3CC(C2)CC1C3 CHEMBL1609005 IC50 0.4 nM
O=C(Nc1ccc(F)c(F)c1F)NC1CCCCCCC1 CHEMBL1818390 IC50 0.4 nM
CC1(C)C2CCC(CNC(=O)Nc3ccc(F)c(F)c3F)C1C2 CHEMBL1818389 IC50 0.4 nM
CC1C(NC(=O)Nc2ccc(F)c(F)c2F)CC2CC1C2(C)C CHEMBL1818388 IC50 0.4 nM
CCCCCCCNC(=O)Nc1ccc(F)c(F)c1F CHEMBL1818387 IC50 0.4 nM
O=C(NCC12CC3CC(CC(C3)C1)C2)Nc1ccc(F)c(F)c1F CHEMBL1818386 IC50 0.4 nM
O=C(Nc1ccc(F)c(F)c1F)NC12CC3CC(CC(C3)C1)C2 CHEMBL1818385 IC50 0.4 nM
O=C(Nc1ccc(F)c(F)c1F)NC1C2CC3CC(C2)CC1C3 CHEMBL1818384 IC50 0.4 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1 CHEMBL374322 IC50 0.4 nM
Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc(O)cc3)CC2)c(C)c1 CHEMBL2313193 IC50 0.4 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1 CHEMBL2436564 IC50 0.4 nM
Cc1cnc(C(=O)N2CCC3(CCN(C(=O)Nc4ccc(OC(F)(F)F)cc4)C3)CC2)cn1 CHEMBL2436577 IC50 0.4 nM
Cc1cc(C(=O)N2CCC3(CCN(C(=O)Nc4ccc(OC(F)(F)F)cc4)C3)CC2)no1 CHEMBL2436578 IC50 0.4 nM
O=C(CCc1cccc(O)c1)N1CCC2(CC1)CCN(C(=O)Nc1ccc(OC(F)(F)F)cc1)C2 CHEMBL2436593 IC50 0.4 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCOC2(CCN(C(=O)C3(c4ccccc4)CC3)CC2)C1 CHEMBL3104441 IC50 0.4 nM
CC(C)(C)OC(=O)N1CCN(CCCCOc2cccc(NC(=O)CC34CC5CC(CC(C5)C3)C4)c2)CC1 CHEMBL3222130 IC50 0.4 nM
O=C(NCCCCCCNC(=O)NCC12CC3CC(CC(C3)C1)C2)NCC12CC3CC(CC(C3)C1)C2 CHEMBL3263289 IC50 0.4 nM
COc1ccc(CNC(=O)c2ccc(F)c(OC3CCCC3)c2)c(C(F)(F)F)c1 CHEMBL4072536 IC50 0.4 nM
COc1ccc(CNC(=O)c2cccc(OC3CCCC3)c2)c(C(F)(F)F)c1 CHEMBL4099452 IC50 0.4 nM
CC12CC3CC1(C)CC3(CNC(=O)Nc1ccc(F)c(F)c1F)C2 CHEMBL4454212 IC50 0.4 nM
O=C(O)c1ccc(O[C@H]2CC[C@H](N3C(=O)C(=O)N(C45CC6CC(CC(Cl)(C6)C4)C5)C3=O)CC2)cc1 CHEMBL4641404 IC50 0.4 nM
O=C(NC12CC3CC(CC(Cl)(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1 CHEMBL4643551 IC50 0.4 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CC2CCC1C2 CHEMBL4746902 IC50 0.4 nM
O=C(NCCCCCCCCCCNC(=O)NC1CC2C=CC1C2)NC1CC2C=CC1C2 CHEMBL4786305 IC50 0.4 nM
O=C(NCCCCCCCCNC(=O)NC1CC2CCC1C2)NC1CC2CCC1C2 CHEMBL4759033 IC50 0.4 nM
CC1(C)C2CCC1(C)C(NC(=O)NCCCCCCCCNC(=O)NC1CC3CCC1(C)C3(C)C)C2 CHEMBL4750771 IC50 0.4 nM
CC12CC3CC(C)(C1)CC(NC(=O)Nc1ccc(C(=O)N4CCCCC4)cc1)(C3)C2 CHEMBL4869434 IC50 0.4 nM
O=C(Nc1ccc(C(=O)N2CCCCC2)cc1)NC1C2CC3CC(C2)CC1C3 CHEMBL4872738 IC50 0.4 nM
O=C(NC12CC3CC(Cl)(CC(C1)c1ccccc13)C2)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1 CHEMBL5084744 IC50 0.4 nM
CC[C@H](C)C(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)c(F)c2)CC1 CHEMBL4752759 IC50 0.4 nM
O=C(CC1CCN(c2ccc(C(=O)O)cc2)CC1)NC12CC3CC(F)(CC(C1)c1ccccc13)C2 CHEMBL5177544 IC50 0.4 nM
CC(C)S(=O)(=O)N1CCC(NC(=O)NC23CC4CC(C)(CC(C2)c2ccccc24)C3)CC1 CHEMBL5197431 IC50 0.4 nM
CC12CC3CC(NC(=O)NC4CCN(C(=O)C5CC5)CC4)(CC(C1)c1ccccc13)C2 CHEMBL5197282 IC50 0.4 nM
O=C(NC1CCN(C(=O)C2CCOCC2)CC1)NC12CC3CC(Cl)(CC(C1)c1ccccc13)C2 CHEMBL5191146 IC50 0.4 nM
O=C(NC1CCN(C(=O)C2CC2)CC1)NC12CC3CC(Cl)(CC(C1)c1ccccc13)C2 CHEMBL5179027 IC50 0.4 nM
O=C(NC1CCN(C(=O)C(F)(F)F)CC1)NC12CC3CC(Cl)(CC(C1)c1ccccc13)C2 CHEMBL5192445 IC50 0.4 nM
O=C(NC1CCN(C(=O)C2CCOCC2)CC1)NC12CC3CC(F)(CC(C1)c1ccccc13)C2 CHEMBL5203787 IC50 0.4 nM
O=C(NC1CCN(C(=O)C2CC2)CC1)NC12CC3CC(F)(CC(C1)c1ccccc13)C2 CHEMBL5177372 IC50 0.4 nM
[2H]C12CC3CC(NC(=O)NC4CCN(C(=O)C5CCOCC5)CC4)(CC(C1)c1ccccc13)C2 CHEMBL5208857 IC50 0.4 nM
O=C(NC1=CC=CC1)NC12CC3CC(CC(C3)C1)C2 CHEMBL5180183 IC50 0.4 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)CCNc2c3c(nc4cc(Cl)ccc24)CCCC3)CC1 CHEMBL5204900 IC50 0.4 nM
CC1=C[C@@H]2Cc3nc4cc(Cl)ccc4c(NCCCCC(=O)N4CCC(NC(=O)Nc5ccc(OC(F)(F)F)cc5)CC4)c3[C@H](C1)C2 CHEMBL5207628 IC50 0.4 nM
C=CC(=O)N1CCCN(C(=O)C2CCCN(Cc3ccc(NC(=O)N[C@@]45C[C@@H]6C[C@@](C)(C[C@@](C)(C6)C4)C5)c(F)c3)C2)CC1 CHEMBL5404981 IC50 0.42 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(CN4CCCC(C(=O)N5CCCN(C(=O)C6CC6)CC5)C4)cc1F)(C3)C2 CHEMBL5404352 IC50 0.42 nM
O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCN(C(=O)CC(F)(F)F)CC1 CHEMBL3327069 Ki 0.43 nM
N#Cc1ccccc1OC1CCN(C(=O)NCc2ccc(Cl)cc2Cl)CC1 CHEMBL589376 EC50 0.44 nM
CCCCS(=O)(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1 CHEMBL3327087 Ki 0.44 nM
CCOC(=O)C1=C(c2ccccc2)NC(=O)NC1c1ccc(NC(=O)c2ccc(Cl)cc2)cc1 CHEMBL4209184 IC50 0.48 nM
CCOC(=O)C1=C(c2ccccc2)NC(=O)NC1c1ccc(NC(=O)c2ccc(C)cc2)cc1 CHEMBL4217562 IC50 0.48 nM
CC(C)CC(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1 CHEMBL3327068 Ki 0.49 nM
O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCN(C(=O)C2CC2)CC1 CHEMBL3327065 Ki 0.49 nM
CC(C)C(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)c(F)c2)CC1 CHEMBL4749102 Ki 0.49 nM
CC(=O)N1CCC(CC(=O)N2CCCN(Cc3ccc(NC(=O)N[C@@]45C[C@@H]6C[C@@](C)(C[C@@](C)(C6)C4)C5)c(F)c3)CC2)CC1 CHEMBL5430033 IC50 0.49 nM
O=C(NC1CCCCCC1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1 CHEMBL221793 IC50 0.5 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCc2c(F)cccc2F)CC1 CHEMBL376647 IC50 0.5 nM
CC(=O)N1CCN(CC(=O)N2CCC(NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)CC1 CHEMBL1257404 IC50 0.5 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)c2cc(O)c(O)c(O)c2)CC1 CHEMBL1257518 IC50 0.5 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1 CHEMBL242459 IC50 0.5 nM
NS(=O)(=O)c1ccc(-n2nc(CCCNC(=O)NC34CC5CC(CC(C5)C3)C4)cc2-c2ccccc2)cc1 CHEMBL1766284 IC50 0.5 nM
NS(=O)(=O)c1ccc(-n2nc(CCCNC(=O)NC3CCCCCC3)cc2-c2ccccc2)cc1 CHEMBL1766285 IC50 0.5 nM
NS(=O)(=O)c1ccc(-n2nc(CCCNC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2ccccc2)cc1 CHEMBL1766288 IC50 0.5 nM
CCCCCCCNC(=O)NC1C2CC3CC(C2)CC1C3 CHEMBL1818402 IC50 0.5 nM
CC(=O)c1cccc(NC(=O)NC2C3CC4CC(C3)CC2C4)c1 CHEMBL1818395 IC50 0.5 nM
O=C(Nc1ccc(I)cc1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2031797 IC50 0.5 nM
O=C(Nc1ccc(Oc2ccccc2)cc1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2031812 IC50 0.5 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(F)cc2)CC1 CHEMBL243335 IC50 0.5 nM
COc1ccc(O[C@H]2CC[C@@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)cc1 CHEMBL244192 IC50 0.5 nM
Cc1noc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1Cl CHEMBL2392762 IC50 0.5 nM
CNc1nc(C)nc(N2CCC(C(=O)NCc3ccc(Br)cc3OC(F)(F)F)CC2)n1 CHEMBL2392692 IC50 0.5 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2)ccn1 CHEMBL2397149 IC50 0.5 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)ccn1 CHEMBL2397136 IC50 0.5 nM
CNC(=O)c1cc(O[C@H]2CC[C@@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)ccn1 CHEMBL2397137 IC50 0.5 nM
CNC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1 CHEMBL2397138 IC50 0.5 nM
CNC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)cc1 CHEMBL2397139 IC50 0.5 nM
CNC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)cc1 CHEMBL2397140 IC50 0.5 nM
O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1 CHEMBL2397147 IC50 0.5 nM
CNC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)cn1 CHEMBL2397146 IC50 0.5 nM
CNC(=O)c1cc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)ccn1 CHEMBL2397143 IC50 0.5 nM
CN(C)C(=O)c1cc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)ccn1 CHEMBL2397142 IC50 0.5 nM
CNC(=O)c1cc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)ccn1 CHEMBL2397141 IC50 0.5 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1 CHEMBL1946170 IC50 0.5 nM
Cc1occc1C(=O)N1CCC2(CCN(C(=O)Nc3ccc(OC(F)(F)F)cc3)C2)CC1 CHEMBL2436580 IC50 0.5 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)C3CC3(F)F)CC2)C1 CHEMBL2436587 IC50 0.5 nM
COc1ccccc1CC(=O)N1CCC2(CC1)CN(C(=O)Nc1ccc(OC(F)(F)F)cc1)CCO2 CHEMBL3104442 IC50 0.5 nM
CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)CC1 CHEMBL3222118 IC50 0.5 nM
CS(=O)(=O)N1CCN(CCCCOc2cccc(NC(=O)CC34CC5CC(CC(C5)C3)C4)c2)CC1 CHEMBL3222131 IC50 0.5 nM
CC(NC(=O)NCCCCCCCCNC(=O)NC(C)C12CC3CC(CC(C3)C1)C2)C12CC3CC(CC(C3)C1)C2 CHEMBL3263297 IC50 0.5 nM
O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)NC1CCC(Oc2ccc(C(=O)O)cc2)CC1 CHEMBL3899098 IC50 0.5 nM
CNC(=O)c1ccc(OC2CCC(NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1 CHEMBL3895613 IC50 0.5 nM
CNC(=O)c1ccc(OC2CCC(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)cc1 CHEMBL3901070 IC50 0.5 nM
CNC(=O)c1cc(OC2CCC(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)ccn1 CHEMBL3928540 IC50 0.5 nM
CC(C)(C)OC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)cn1 CHEMBL3677982 IC50 0.5 nM
CC(C)(C)OC(=O)c1cc(O[C@H]2CC[C@@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)ccn1 CHEMBL3677983 IC50 0.5 nM
CCN(CC)C(=O)c1cc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)ccn1 CHEMBL3353250 IC50 0.5 nM
CCN(CC)C(=O)c1cc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)ccn1 CHEMBL3677985 IC50 0.5 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccnc(C(=O)N3CCCC3)c2)CC1 CHEMBL3677986 IC50 0.5 nM
N#Cc1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(C(F)(F)F)cc3)CC2)cc1 CHEMBL3677987 IC50 0.5 nM
N#Cc1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(Cl)cc3)CC2)cc1 CHEMBL3677988 IC50 0.5 nM
N#Cc1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1 CHEMBL3677989 IC50 0.5 nM
CC12CC3CC1(C)CC3(NC(=O)Nc1ccc(F)c(F)c1F)C2 CHEMBL4448782 IC50 0.5 nM
O=C(NC1C2CC3C4CC5CC3C1C(C5)C4C2)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1 CHEMBL4535555 IC50 0.5 nM
O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCN(C(=O)c2cc[nH]c2)CC1 CHEMBL4749079 Ki 0.5 nM
O=C(NC12CC3CC(F)(CC(C1)c1ccccc13)C2)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1 CHEMBL5093683 IC50 0.5 nM
C#CCCC1(CCC(=O)N2CCC(NC(=O)NC34CC5CC(Cl)(CC(C3)c3ccccc35)C4)CC2)N=N1 CHEMBL5196519 IC50 0.5 nM
Cc1cc(C(=O)Nc2ccc(Cl)cc2)ccc1N(CCN1CCCC1=O)C(=O)Nc1ccc(Cl)cc1 CHEMBL5202839 IC50 0.5 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2ccc(C(=O)O)cc2)CC1 CHEMBL244405 IC50 0.5 nM
Cc1occc1C(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1 CHEMBL4740401 Ki 0.51 nM
Cc1occc1C(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1 CHEMBL4743354 Ki 0.55 nM
CCC(=O)N1CCCN(C(=O)C2CCCN(C(=O)c3ccc(NC(=O)N[C@@]45C[C@@H]6C[C@@](C)(C[C@@](C)(C6)C4)C5)c(F)c3)C2)CC1 CHEMBL5429531 IC50 0.56 nM
O=C(Nc1ccc(Br)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1 CHEMBL221737 IC50 0.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@@H](Oc2cccc(C(=O)O)c2)CC1 CHEMBL244002 IC50 0.6 nM
CS(=O)(=O)c1ccc(C(CCNC(=O)c2cccnc2)c2ccc(F)cc2)cc1 CHEMBL564145 EC50 0.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)c2ccc(Cl)nc2)CC1 CHEMBL1257170 IC50 0.6 nM
O=C(Nc1ccc(OCCN2CCOCC2)c(Cl)c1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2032045 IC50 0.6 nM
Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc4cc(C(=O)O)ccc4c3)CC2)c(C)c1 CHEMBL2313183 IC50 0.6 nM
Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccccc3Br)CC2)c(C)c1 CHEMBL2313191 IC50 0.6 nM
O=C(CC1CC1)N1CCC2(CC1)CCN(C(=O)Nc1ccc(OC(F)(F)F)cc1)C2 CHEMBL2436589 IC50 0.6 nM
CC(C)(C)C(=O)N1CCC2(CCN(C(=O)Nc3ccc(OC(F)(F)F)cc3)C2)CC1 CHEMBL2436590 IC50 0.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCOC2(CCN(C(=O)C3CCCCC3)CC2)C1 CHEMBL3104440 IC50 0.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3cc(Cl)ccn3)CC2)C1 CHEMBL3104435 IC50 0.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3cnoc3C3CC3)CC2)C1 CHEMBL3104432 IC50 0.6 nM
CC(=O)N1CCN(CCCCOc2cccc(NC(=O)CC34CC5CC(CC(C5)C3)C4)c2)CC1 CHEMBL3222129 IC50 0.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@@H](Oc2ccc(C(=O)O)cc2)CC1 CHEMBL1552108 IC50 0.6 nM
COc1ccc(CNC(=O)c2ccc(OC)c(OC3CCCC3)c2)c(C(F)(F)F)c1 CHEMBL4097831 IC50 0.6 nM
Cc1cc(NC(=O)Nc2ccc(Cl)c(Cl)c2)ccc1OCc1nc2ccccc2s1 CHEMBL4467796 IC50 0.6 nM
CCC(=O)N1CCC(NC(=O)NC23CC4CC(Cl)(CC(C2)c2ccccc24)C3)CC1 CHEMBL5197313 IC50 0.6 nM
CC(C)S(=O)(=O)N1CCC(NC(=O)NC23CC4CC(Cl)(CC(C2)c2ccccc24)C3)CC1 CHEMBL5179500 IC50 0.6 nM
O=C(NC1CCN(C(=O)C2(F)CC2)CC1)NC12CC3CC(Cl)(CC(C1)c1ccccc13)C2 CHEMBL5203245 IC50 0.6 nM
CC(=O)N1CCCN(C(=O)C2CCCN(C(=O)c3ccc(NC(=O)N[C@@]45C[C@@H]6C[C@@](C)(C[C@@](C)(C6)C4)C5)c(F)c3)C2)CC1 CHEMBL5432207 IC50 0.6 nM
N#Cc1cccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c1 CHEMBL589620 EC50 0.63 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(CN4CCCC(C(=O)NCCO)C4)cc1F)(C3)C2 CHEMBL5410521 IC50 0.63 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc([N+](=O)[O-])cc2)CC1 CHEMBL397694 IC50 0.64 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)c2cc[nH]c2)CC1 CHEMBL4740980 Ki 0.64 nM
CC(C)C(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1 CHEMBL3327064 Ki 0.66 nM
O=C(Nc1ccc(Cl)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1 CHEMBL374730 IC50 0.7 nM
CCC(C)OC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL224912 IC50 0.7 nM
CCC(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1 CHEMBL1258670 IC50 0.7 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)c2ccncc2)CC1 CHEMBL1257169 IC50 0.7 nM
Nc1ccc(NS(=O)(=O)c2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)cc1 CHEMBL2392747 IC50 0.7 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3ccccc3F)CC2)C1 CHEMBL2436572 IC50 0.7 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)C3CCCCC3)CC2)C1 CHEMBL2436584 IC50 0.7 nM
O=C(Cc1ccccn1)N1CCC2(CC1)CN(C(=O)Nc1ccc(OC(F)(F)F)cc1)CCO2 CHEMBL3104443 IC50 0.7 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1 CHEMBL3104444 IC50 0.7 nM
O=C(N[C@@H]1[C@@H](c2ccccc2)[C@H]1c1ccccc1)N1CCC[C@@H](NS(=O)(=O)c2ccc(F)cc2)C1 CHEMBL3401639 IC50 0.7 nM
O=C(NCC12CC3CC(CC(C3)C1)C2)Nc1ccccc1F CHEMBL4633887 IC50 0.7 nM
O=C(NCC12CC3CC(CC(C3)C1)C2)NC1CC2C=CC1C2 CHEMBL4800466 IC50 0.7 nM
O=C(Nc1ccc(OC(F)(F)F)c(F)c1)NC1CCN(C(=O)[C@@H]2CCOC2)CC1 CHEMBL4742765 Ki 0.7 nM
O=C(Nc1ccc(OC(F)(F)F)c(F)c1)NC1CCN(C(=O)N2CCOCC2)CC1 CHEMBL4764831 Ki 0.7 nM
CNc1nc(NCc2ccc(C(=O)NCc3ccccc3C(F)(F)F)cc2)nc(N2CCN(C)CC2)n1 CHEMBL4875337 IC50 0.7 nM
CC(C)CNC(=O)c1ccc(NC(=O)NC23CC4CC(C)(CC(C)(C4)C2)C3)cc1 CHEMBL4851331 IC50 0.7 nM
CN(C)C(=O)C1CCCN(Cc2ccc(NC(=O)N[C@@]34C[C@@H]5C[C@@](C)(C[C@@](C)(C5)C3)C4)c(F)c2)C1 CHEMBL5435557 IC50 0.7 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2ccc([N+](=O)[O-])cc2)CC1 CHEMBL244193 IC50 0.72 nM
O=C(Nc1ccc(OC(F)(F)F)c(F)c1)NC1CCN(C(=O)C2CCOCC2)CC1 CHEMBL4776917 Ki 0.75 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)C2=COCC2)CC1 CHEMBL4756688 Ki 0.77 nM
CCC(C)C(=O)N1CCC(CC(=O)N2CCCN(Cc3ccc(NC(=O)N[C@@]45C[C@@H]6C[C@@](C)(C[C@@](C)(C6)C4)C5)c(F)c3)CC2)CC1 CHEMBL5431410 IC50 0.77 nM
N#Cc1ccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1 CHEMBL589859 EC50 0.78 nM
O=C(Nc1ccc(OC(F)(F)F)c(F)c1)NC1CCN(C(=O)C2CCCOC2)CC1 CHEMBL4782162 Ki 0.78 nM
CCCCOC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL223281 IC50 0.8 nM
O=C(Nc1cccc(OCCCN2CCOCC2)c1)NC12CC3CC(CC(C3)C1)C2 CHEMBL458165 IC50 0.8 nM
O=C(Nc1ccc(F)c(OCCCN2CCOCC2)c1)NC12CC3CC(CC(C3)C1)C2 CHEMBL560384 IC50 0.8 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)Nc1ccc(F)c(OCCCN2CCOCC2)c1 CHEMBL560982 IC50 0.8 nM
O=C(Nc1ccc(OCCCN2CCOCC2)cc1)Nc1ccc(C(F)(F)F)cc1 CHEMBL561383 IC50 0.8 nM
O=C(Nc1ccc(OCCCN2CCOCC2)cc1)Nc1ccc(OC(F)(F)F)cc1 CHEMBL551521 IC50 0.8 nM
CN(C)c1cccc2c(S(=O)(=O)N3CCC(NC(=O)Nc4ccc(OC(F)(F)F)cc4)CC3)cccc12 CHEMBL1257880 IC50 0.8 nM
CC(=O)N1CCC(NC(=O)NC2CCCCCC2)CC1 CHEMBL1668928 IC50 0.8 nM
NS(=O)(=O)c1ccc(-n2nc(CCCNC(=O)Nc3ccccc3)cc2-c2ccccc2)cc1 CHEMBL1766283 IC50 0.8 nM
NS(=O)(=O)c1ccc(-n2nc(CCCNC(=O)Nc3ccc(Cl)cc3)cc2-c2ccccc2)cc1 CHEMBL1766286 IC50 0.8 nM
CCOC(=O)COc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 CHEMBL2031808 IC50 0.8 nM
CCOC(=O)C(F)(F)Oc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 CHEMBL2031930 IC50 0.8 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCCCC1 CHEMBL2031931 IC50 0.8 nM
COc1ccc(O[C@H]2CC[C@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)cc1 CHEMBL427695 IC50 0.8 nM
Cc1onc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1Br CHEMBL2392758 IC50 0.8 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3cccc4[nH]cnc34)CC2)C1 CHEMBL2436576 IC50 0.8 nM
CCCCC(=O)N1CCC2(CC1)CCN(C(=O)Nc1ccc(OC(F)(F)F)cc1)C2 CHEMBL2436592 IC50 0.8 nM
CC(=O)Nc1ccccc1C(=O)N1CCC2(CC1)CN(C(=O)Nc1ccc(C(F)(F)F)cc1)CCO2 CHEMBL3104622 IC50 0.8 nM
Cc1cc(NC(=O)Nc2cc(Cl)cc(Cl)c2)ccc1OCc1nc2ccccc2s1 CHEMBL4559364 IC50 0.8 nM
O=C(NCCCCCCNC(=O)NCCC12CC3CC(CC(C3)C1)C2)NCCC12CC3CC(CC(C3)C1)C2 CHEMBL4645669 IC50 0.8 nM
Cc1cc(C(=O)Nc2ccc(F)cn2)ccc1N(CCN1CCCC1=O)C(=O)Nc1ccc(Cl)cc1 CHEMBL5173452 IC50 0.8 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(C(=O)NC4CCC(C(=O)NCCO)CC4)cc1F)(C3)C2 CHEMBL5399478 IC50 0.8 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2cc(F)cc(F)c2)CC1 CHEMBL396546 IC50 0.82 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(C(=O)N4CCCC(C(=O)N5CCN(CCO)CC5)C4)cc1F)(C3)C2 CHEMBL5422052 IC50 0.84 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(C(=O)NC4CCC(C(N)=O)CC4)cc1F)(C3)C2 CHEMBL5417426 IC50 0.84 nM
CCC(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)c(F)c2)CC1 CHEMBL4749869 Ki 0.87 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1 CHEMBL221014 IC50 0.9 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](OCc2ccccc2)CC1 CHEMBL242898 IC50 0.9 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2cccc(C(=O)O)c2)CC1 CHEMBL243793 IC50 0.9 nM
NS(=O)(=O)c1ccc(-n2nc(CCCNC(=O)Nc3ccc(C(F)(F)F)cc3)cc2-c2ccccc2)cc1 CHEMBL1766287 IC50 0.9 nM
O=C(Nc1cccc(Oc2ccccc2)c1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2031816 IC50 0.9 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3ccco3)CC2)C1 CHEMBL2436581 IC50 0.9 nM
Cc1cnc(C(=O)N2CCC3(CC2)CN(C(=O)Nc2ccc(OC(F)(F)F)cc2)CCO3)cn1 CHEMBL3104436 IC50 0.9 nM
CC(C)(C)OC(=O)c1cc(OC2CCC(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)ccn1 CHEMBL3917808 IC50 0.9 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1 CHEMBL3677984 IC50 0.9 nM
O=C(NC1CC2C=CC1C2)NC1C2CC3CC(C2)CC1C3 CHEMBL4776297 IC50 0.9 nM
CC(C)CNC(=O)c1ccc(NC(=O)NC2C3CC4CC(C3)CC2C4)cc1 CHEMBL4853005 IC50 0.9 nM
CC12CC3CC(NC(=O)N[C@H]4CC[C@H](Oc5ccc(C(=O)O)cc5)CC4)(CC(C1)c1ccccc13)C2 CHEMBL5081862 IC50 0.9 nM
Cc1cc(C(=O)Nc2ccc(F)cn2)ccc1N(CCN1CCOCC1)C(=O)Nc1ccc(Cl)cc1 CHEMBL5201407 IC50 0.9 nM
Cc1cc(C(=O)Nc2ccc(F)cn2)ccc1N(CCN1CCCC1)C(=O)Nc1ccc(Cl)cc1 CHEMBL5203957 IC50 0.9 nM
C=C(C)C(=O)N1CCCN(C(=O)C2CCCN(Cc3ccc(NC(=O)N[C@@]45C[C@@H]6C[C@@](C)(C[C@@](C)(C6)C4)C5)c(F)c3)C2)CC1 CHEMBL5435984 IC50 0.9 nM
CCC(=O)N1CCC(CC(=O)N2CCCN(C(=O)c3ccc(NC(=O)N[C@@]45C[C@@H]6C[C@@](C)(C[C@@](C)(C6)C4)C5)c(F)c3)CC2)CC1 CHEMBL5394017 IC50 0.9 nM
CCC(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1 CHEMBL1258904 Ki 0.91 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(C(=O)NC4CCC(C(=O)NC(CO)CO)CC4)cc1F)(C3)C2 CHEMBL5421374 IC50 0.91 nM
CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C CHEMBL3628776 IC50 0.96 nM
CCOC(=O)C1=C(c2ccccc2)NC(=O)NC1c1ccc(NC(=O)c2ccc(F)cc2)cc1 CHEMBL4214103 IC50 0.96 nM
CS(=O)(=O)c1ccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1 CHEMBL592742 EC50 0.97 nM
CCCCS(=O)(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1 CHEMBL3327086 Ki 0.98 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(CN4CCCC(C(=O)N5CCN(CCO)CC5)C4)cc1F)(C3)C2 CHEMBL5435276 IC50 0.98 nM
CCC(C)C(=O)N1CCC(NC(=O)NC2CCCCCC2)CC1 CHEMBL3327076 Ki 0.99 nM
O=C(Nc1ccc(I)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1 CHEMBL220908 IC50 1.0 nM
C=CCOC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL375240 IC50 1.0 nM
CCCOC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL224359 IC50 1.0 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2cc(F)cc(F)c2)CC1 CHEMBL243336 IC50 1.0 nM
CS(=O)(=O)c1ccc2c(c1)CCC1(CCN(C(=O)Cc3ccc(Cl)cc3Cl)CC1)O2 CHEMBL497829 IC50 1.0 nM
O=C1CC2(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)Oc2ccc(-c3ccncc3)cc21 CHEMBL495992 IC50 1.0 nM
CCCCn1c(-c2cc(OC)c(OC)c(OC)c2)nc2cc(C(=O)NCc3cccc(OC)c3OC)ccc21 CHEMBL550648 IC50 1.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)Nc1cccc(OCCCN2CCOCC2)c1 CHEMBL456836 IC50 1.0 nM
CC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1 CHEMBL1079360 IC50 1.0 nM
CC1(c2ccccc2)CCCN(C(=O)NCc2ccc(-c3ccccn3)cc2)C1 CHEMBL1081703 IC50 1.0 nM
CC1(c2ccccc2)CCCN(C(=O)NCCc2ccc(Cl)cc2)C1 CHEMBL1078265 IC50 1.0 nM
CC1(c2ccccc2)CCCN(C(=O)N[C@H]2C[C@@H]2c2ccccc2)C1 CHEMBL1077780 IC50 1.0 nM
O=C(Nc1ccc(Cl)cc1)N1CCCC(CCO)(c2ccccc2)C1 CHEMBL1079290 IC50 1.0 nM
O=C(Nc1ccc(C(=O)NCCN2CCOCC2)cc1)Nc1ccc(C(F)(F)F)cc1 CHEMBL1086820 IC50 1.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(S(=O)(=O)N2CCOCC2)cc1 CHEMBL1088083 IC50 1.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(S(=O)(=O)CCCN2CCOCC2)cc1 CHEMBL1088227 IC50 1.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)Nc1cccc(S(=O)(=O)NCCN2CCOCC2)c1 CHEMBL1099390 IC50 1.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)Nc1cccc(S(=O)(=O)N2CCOCC2)c1 CHEMBL1088366 IC50 1.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)Nc1cccc(S(=O)(=O)CCCN2CCOCC2)c1 CHEMBL1087723 IC50 1.0 nM
O=C(NCCC(c1ccc(F)cc1)c1ccc(F)cc1)N1CCC(Oc2cnccn2)CC1 CHEMBL1083622 IC50 1.0 nM
O=C(Nc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)cc1)c1ccccc1 CHEMBL1271550 IC50 1.0 nM
CS(=O)(=O)N1CCN(CCCCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1 CHEMBL1632484 IC50 1.0 nM
CCCCCCNC(=O)NC1C2CC3CC(C2)CC1C3 CHEMBL1818401 IC50 1.0 nM
O=C(NCCCc1ccccc1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2031923 IC50 1.0 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OC(=O)c2ccccc2)CC1 CHEMBL2031950 IC50 1.0 nM
COCCNc1nc(C)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1 CHEMBL2392698 IC50 1.0 nM
CNc1nc(C)nc(N2CCC(C(=O)NCc3ccc(OC)cc3C(F)(F)F)CC2)n1 CHEMBL2392691 IC50 1.0 nM
CNc1nc(C)nc(N2CCC(C(=O)NCc3ccccc3OC(F)(F)F)CC2)n1 CHEMBL2392706 IC50 1.0 nM
Cc1nc(N2CCOCC2)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1 CHEMBL2392697 IC50 1.0 nM
Cc1nc(NC(C)C)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1 CHEMBL2392696 IC50 1.0 nM
Cc1nc(N(C)C)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1 CHEMBL2392695 IC50 1.0 nM
CNc1nc(-c2ccccc2)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1 CHEMBL2392694 IC50 1.0 nM
CNc1nc(C2CCCCC2)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1 CHEMBL2392693 IC50 1.0 nM
CNC(=O)c1cccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)c1 CHEMBL2397145 IC50 1.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3ccc(Cl)cc3)CC2)C1 CHEMBL3104621 IC50 1.0 nM
CS(=O)(=O)N1CCN(C(=O)c2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)CC1 CHEMBL3222119 IC50 1.0 nM
CC(C)(C)c1ccc(C(=O)NCc2ccc(NS(C)(=O)=O)cc2Cl)cc1 CHEMBL4066332 IC50 1.0 nM
COc1ccc(C(=O)NCc2ccc(OC)cc2C(F)(F)F)cc1 CHEMBL4091712 IC50 1.0 nM
O=C(Nc1ccccc1F)NC1C2CC3CC(C2)CC1C3 CHEMBL4637039 IC50 1.0 nM
O=C(Nc1ccc(Sc2ccccc2Cl)cc1)C1CCN(C(=O)c2ccc(F)cc2)CC1 CHEMBL4749356 IC50 1.0 nM
CNc1nc(Oc2cccc(C(=O)NCc3ccccc3C(F)(F)F)c2)nc(N2CCN(C)CC2)n1 CHEMBL4862566 IC50 1.0 nM
CC12CC3CC(NC(=O)Nc4ccc(F)c(F)c4F)(CC(C1)c1ccccc13)C2 CHEMBL5080024 IC50 1.0 nM
CCC(=O)N1CCC(NC(=O)NC23CC4CC(C)(CC(C2)c2ccccc24)C3)CC1 CHEMBL5193653 IC50 1.0 nM
CC12CC3CC(NC(=O)NC4CCN(C(=O)C5CCOCC5)CC4)(CC(C1)c1ccccc13)C2 CHEMBL5179393 IC50 1.0 nM
Cc1cc(C(=O)Nc2ccc3c(c2)OCO3)ccc1N(CCN1CCOCC1)C(=O)Nc1ccc(Cl)cc1 CHEMBL5189164 IC50 1.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)CCCNc2c3c(nc4cc(Cl)ccc24)CCCC3)CC1 CHEMBL5200047 IC50 1.0 nM
CCC(C)C(=O)N1CCC(CC(=O)N2CCCN(C(=O)c3ccc(NC(=O)N[C@@]45C[C@@H]6C[C@@H](C[C@@](C)(C6)C4)C5)c(F)c3)CC2)CC1 CHEMBL5430521 IC50 1.0 nM
C=C(C)C(=O)N1CCC(CC(=O)N2CCCN(C(=O)c3ccc(NC(=O)N[C@@]45C[C@@H]6C[C@@](C)(C[C@@](C)(C6)C4)C5)cc3)CC2)CC1 CHEMBL5433817 IC50 1.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCN(C(=O)C2=COCC2)CC1 CHEMBL4796253 Ki 1.03 nM
COC(=O)c1ccc(C(=O)N2CCC(NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)cc1 CHEMBL215999 IC50 1.1 nM
COC(=O)c1cccc(C(=O)N2CCC(NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)c1 CHEMBL384744 IC50 1.1 nM
O=C(NC1CCN(C(=O)C(F)(F)F)CC1)NC12CC3CC(CC(C3)C1)C2 CHEMBL217758 IC50 1.1 nM
CC(C)OC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL427070 IC50 1.1 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](OCc2c(F)cccc2F)CC1 CHEMBL395738 IC50 1.1 nM
CCOCCOCCOc1cccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1 CHEMBL396760 IC50 1.1 nM
CCOCCOCCOc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 CHEMBL438867 IC50 1.1 nM
N#Cc1ccc(NC(=O)NC2C3CC4CC(C3)CC2C4)cc1 CHEMBL1818393 IC50 1.1 nM
CC(C)c1ccc(NC(=O)NCC2CCCCC2)cc1 CHEMBL2031927 IC50 1.1 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(Br)cc2)CC1 CHEMBL243125 IC50 1.1 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCc2ccccc2)CC1 CHEMBL395988 IC50 1.1 nM
Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccccc3F)CC2)c(C)c1 CHEMBL2313190 IC50 1.1 nM
O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)N1CCC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1 CHEMBL2436568 IC50 1.1 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3c[nH]nc3C3CC3)CC2)C1 CHEMBL3104433 IC50 1.1 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3ccccc3F)CC2)C1 CHEMBL3102876 IC50 1.1 nM
O=C(NCC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)Nc1ccc2c(ccn2CCc2ccc(F)cc2)c1 CHEMBL5411340 IC50 1.1 nM
COC(=O)N1CCC(CC(=O)N2CCCN(Cc3ccc(NC(=O)N[C@@]45C[C@@H]6C[C@@](C)(C[C@@](C)(C6)C4)C5)c(F)c3)CC2)CC1 CHEMBL5421307 IC50 1.1 nM
CC(C)S(=O)(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1 CHEMBL1668939 Ki 1.17 nM
CCC(C)C(=O)N1CCC(NC(=O)Nc2ccc(C(C)C)cc2)CC1 CHEMBL3327071 Ki 1.17 nM
O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCN(C(=O)[C@@H]2CCOC2)CC1 CHEMBL4746684 Ki 1.19 nM
O=C(NC1CCN(C(=O)c2ccccn2)CC1)NC12CC3CC(CC(C3)C1)C2 CHEMBL215161 IC50 1.2 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1 CHEMBL221015 IC50 1.2 nM
CC(C)COC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL224448 IC50 1.2 nM
CCCCCOC1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL439577 IC50 1.2 nM
COC(=O)c1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1O CHEMBL476614 IC50 1.2 nM
O=C(Nc1ccc(F)c(F)c1F)NC1CCCCC1 CHEMBL1818391 IC50 1.2 nM
CCCCCO[C@H]1CC[C@H](NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL2031926 IC50 1.2 nM
CCOCCOCCOCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL2031941 IC50 1.2 nM
Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccccc3O)CC2)c(C)c1 CHEMBL2313192 IC50 1.2 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)C3CCC(O)CC3)CC2)C1 CHEMBL2436585 IC50 1.2 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3cccc(Cl)c3)CC2)C1 CHEMBL3104620 IC50 1.2 nM
CON(C)C(=O)C(=O)N(C)c1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 CHEMBL3103821 IC50 1.2 nM
CC(NC(=O)NCCCCNC(=O)NC(C)C12CC3CC(CC(C3)C1)C2)C12CC3CC(CC(C3)C1)C2 CHEMBL3263294 IC50 1.2 nM
O=C(NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2 CHEMBL3263303 IC50 1.2 nM
O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCN(C(=O)CCC(F)(F)F)CC1 CHEMBL3327070 Ki 1.2 nM
C[C@H](C#Cc1cccc(C(=O)NCCC(c2ccc(F)cc2)c2ccc(F)cc2)c1)N(O)C(N)=O CHEMBL4800490 IC50 1.2 nM
O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCN(C(=O)c2ccoc2)CC1 CHEMBL4760004 Ki 1.21 nM
O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCN(S(=O)(=O)C2CC2)CC1 CHEMBL3327084 Ki 1.22 nM
CCOC(=O)C1=C(c2ccccc2)NC(=O)NC1c1ccc(NC(=O)c2ccccc2)cc1 CHEMBL4204830 IC50 1.22 nM
CCC(C)C(=O)N1CCC(NC(=O)NC2CCCCC2)CC1 CHEMBL3327075 Ki 1.23 nM
O=C(NC1CCN(C(=O)c2ccccc2)CC1)NC12CC3CC(CC(C3)C1)C2 CHEMBL216016 IC50 1.3 nM
CC(C)(C)OC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL224740 IC50 1.3 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2ccc(Br)cc2)CC1 CHEMBL243337 IC50 1.3 nM
O=C(Nc1ccc(OCCCN2CCOCC2)cc1)NC12CC3CC(CC(C3)C1)C2 CHEMBL245159 IC50 1.3 nM
O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(F)c(OCCCN2CCOCC2)c1 CHEMBL560662 IC50 1.3 nM
O=C(CC12CC3CC(CC(C3)C1)C2)Nc1ccc(OCCCN2CCOCC2)cc1 CHEMBL549576 IC50 1.3 nM
O=C(Nc1ccc(Cl)cc1)N1CCCC(CCCO)(c2ccccc2)C1 CHEMBL1079291 IC50 1.3 nM
CC(=O)c1cccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1 CHEMBL2031807 IC50 1.3 nM
C=CCO[C@H]1CC[C@@H](NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL2031951 IC50 1.3 nM
CC1CC1C(=O)N1CCC2(CCN(C(=O)Nc3ccc(OC(F)(F)F)cc3)C2)CC1 CHEMBL2436588 IC50 1.3 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1 CHEMBL3104617 IC50 1.3 nM
O=C(NCCCCCOCCOCCOCC(F)(F)F)NC12CC3CC(CC(C3)C1)C2 CHEMBL396980 IC50 1.4 nM
O=C(CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1)NC1=NNNN1 CHEMBL1079245 IC50 1.4 nM
O=C(Nc1cccc(OCCCCN2CCN(C(=O)CCl)CC2)c1)NC12CC3CC(CC(C3)C1)C2 CHEMBL1632483 IC50 1.4 nM
Cc1cc(C(=O)N2CCC3(CC2)CN(C(=O)Nc2ccc(OC(F)(F)F)cc2)CCO3)no1 CHEMBL3104431 IC50 1.4 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3ccccc3Cl)CC2)C1 CHEMBL3104619 IC50 1.4 nM
CS(=O)(=O)N[C@@H]1CCCN(C(=O)N[C@@H]2[C@@H](c3ccccc3)[C@H]2c2ccccc2)C1 CHEMBL3401638 IC50 1.4 nM
O=C(Nc1ccc(C(=O)NC2CCCCC2)cc1)NC1C2CC3CC(C2)CC1C3 CHEMBL4872410 IC50 1.4 nM
CCC(C)C(=O)N1CCCN(C(=O)C2CCCN(C(=O)c3ccc(NC(=O)N[C@@]45C[C@@H]6C[C@@](C)(C[C@@](C)(C6)C4)C5)c(F)c3)C2)CC1 CHEMBL5431664 IC50 1.4 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)[C@@H]2CCOC2)CC1 CHEMBL4750425 Ki 1.41 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)C2CCOCC2)CC1 CHEMBL4744784 Ki 1.43 nM
COc1ccc(CNC(=O)[C@@H]2CCC[C@H](Nc3ccc([N+](=O)[O-])c4nonc34)C2)c(C(F)(F)F)c1 CHEMBL5192349 IC50 1.43 nM
CCCS(=O)(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1 CHEMBL3327083 Ki 1.47 nM
COC(=O)c1ccc(C(=O)N2CCC(CNC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)cc1 CHEMBL215908 IC50 1.5 nM
O=C(NCCCCCCCCCCCC(=O)OC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2 CHEMBL390796 IC50 1.5 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](OCc2c(Cl)cccc2Cl)CC1 CHEMBL242025 IC50 1.5 nM
O=C(Nc1ccc(Cl)cc1)Nc1ccc(OCCCN2CCOCC2)cc1 CHEMBL551061 IC50 1.5 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)CN2CCN(Cc3ccccc3)CC2)CC1 CHEMBL1257286 IC50 1.5 nM
O=C(Nc1cccc(OC(F)(F)C(F)F)c1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2031802 IC50 1.5 nM
COc1ccc(CNC(=O)c2ccc(OC(F)F)cc2)c(C(F)(F)F)c1 CHEMBL4063944 IC50 1.5 nM
O=C(NCCCCCCCCNC(=O)NCCC12CC3CC(CC(C3)C1)C2)NCCC12CC3CC(CC(C3)C1)C2 CHEMBL4641883 IC50 1.5 nM
O=C(NC1CC2C=CC1C2)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1 CHEMBL4755752 IC50 1.5 nM
CC(O)CNC(=O)C1CCC(NC(=O)c2ccc(NC(=O)N[C@@]34C[C@@H]5C[C@@](C)(C[C@@](C)(C5)C3)C4)c(F)c2)CC1 CHEMBL5438968 IC50 1.54 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(CN4CCC(C(N)=O)CC4)cc1F)(C3)C2 CHEMBL5415121 IC50 1.54 nM
CCOC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL223900 IC50 1.6 nM
O=C(NC1CCCCC1)NC12CC3CC(CC(C3)C1)C2 CHEMBL242255 IC50 1.6 nM
Cc1ccccc1CO[C@H]1CC[C@H](NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL395989 IC50 1.6 nM
CCOCCOCCOC1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL244068 IC50 1.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)c2cccnc2)CC1 CHEMBL1668937 IC50 1.6 nM
CC(C)S(=O)(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1 CHEMBL1668940 IC50 1.6 nM
CCCCCCCNC(=O)Nc1ccc(C)c(Cl)c1 CHEMBL1818403 IC50 1.6 nM
Cc1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)c(C)c1 CHEMBL1933651 IC50 1.6 nM
CSc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 CHEMBL2031803 IC50 1.6 nM
O=C(Nc1ccc(C(=O)c2ccccc2)cc1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2031814 IC50 1.6 nM
CCOC(=O)c1ccc(O[C@H]2CC[C@@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)cc1 CHEMBL2031924 IC50 1.6 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](OC2CCCCC2)CC1 CHEMBL2031789 IC50 1.6 nM
Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)CC2)c(C)c1 CHEMBL2313176 IC50 1.6 nM
O=C1C(=O)N(C23CC4CC(CC(C4)C2)C3)C(=O)N1CCCCCCN1C(=O)C(=O)N(C23CC4CC(CC(C4)C2)C3)C1=O CHEMBL4642121 IC50 1.6 nM
C[C@H](C#Cc1cccc(C(=O)NCCC(c2ccc(F)cc2)c2ccc(C(F)(F)F)cc2)c1)N(O)C(N)=O CHEMBL4746942 IC50 1.6 nM
CC(=O)N1CCC(NC(=O)NC23CC4CC(Cl)(CC(C2)c2ccccc24)C3)CC1 CHEMBL5195267 IC50 1.6 nM
CS(=O)(=O)c1ccccc1OC1CCN(C(=O)NCc2ccc(Cl)cc2Cl)CC1 CHEMBL589860 EC50 1.65 nM
COC(=O)c1ccccc1C(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL214644 IC50 1.7 nM
O=C(NC1CCN(C(=O)c2cccnc2)CC1)NC12CC3CC(CC(C3)C1)C2 CHEMBL214128 IC50 1.7 nM
O=C(NCCCCCCCCCCCC(=O)OCc1ccccc1Cl)NC12CC3CC(CC(C3)C1)C2 CHEMBL225271 IC50 1.7 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCc2c(Cl)cccc2Cl)CC1 CHEMBL243124 IC50 1.7 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCc2ccc(Br)cc2)CC1 CHEMBL242899 IC50 1.7 nM
CCc1ccc(OCCOCCOCCCCCNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 CHEMBL245148 IC50 1.7 nM
CS(=O)(=O)c1ccc([C@@H](CCNC(=O)c2ccc(O)cc2)c2ccc(F)cc2)cc1 CHEMBL2021549 EC50 1.7 nM
O=C(O)c1ccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1 CHEMBL608263 EC50 1.7 nM
COc1cc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc(C(F)(F)F)c1 CHEMBL2031800 IC50 1.7 nM
CC(C)c1ccc(NC(=O)NC2CCCCC2)cc1 CHEMBL1360431 IC50 1.7 nM
Cc1ccc(S(=O)(=O)N2CCC(C(=O)NC34CC5CC(CC(C5)C3)C4)CC2)c(C)c1 CHEMBL2313189 IC50 1.7 nM
CC(C)OP(=O)(OC(C)C)C(Nc1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C CHEMBL3628778 IC50 1.7 nM
COc1ccc(CNC(=O)C2CCN(C(=O)OC(C)(C)C)CC2)c(C(F)(F)F)c1 CHEMBL4073578 IC50 1.7 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)C2CCOC2)CC1 CHEMBL4763353 Ki 1.7 nM
Cc1cc(C(=O)Nc2ccc(Cl)cc2)ccc1N(CC(=O)N1CCOCC1)C(=O)Nc1ccc(Cl)cc1 CHEMBL5203928 IC50 1.7 nM
O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCN(C(=O)C2CCOCC2)CC1 CHEMBL4800691 Ki 1.73 nM
CCS(=O)(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1 CHEMBL3327082 Ki 1.74 nM
O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCN(C(=O)C2CCOC2)CC1 CHEMBL4780067 Ki 1.74 nM
O=C(NCC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)Nc1ccc2c(ccn2Cc2ccc(F)cc2)c1 CHEMBL5438483 IC50 1.752 nM
O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCN(S(=O)(=O)CC(F)(F)F)CC1 CHEMBL3327085 Ki 1.79 nM
COC(=O)c1ccccc1C(=O)N1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL384280 IC50 1.8 nM
O=C(NCC1CCN(C(=O)C(F)(F)F)CC1)NC12CC3CC(CC(C3)C1)C2 CHEMBL214127 IC50 1.8 nM
C#CCOC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL223956 IC50 1.8 nM
O=C(NC1CCC(OCCCN2CCOCC2)CC1)NC12CC3CC(CC(C3)C1)C2 CHEMBL245158 IC50 1.8 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(S(=O)(=O)c2ccccc2)CC1 CHEMBL1257758 IC50 1.8 nM
O=C(Nc1cccc(OCCCCN2CCN(C(=O)C(F)(F)F)CC2)c1)NC12CC3CC(CC(C3)C1)C2 CHEMBL1632482 IC50 1.8 nM
O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)NC12CC3CC(CC(C3)C1)C2 CHEMBL388015 IC50 1.8 nM
CCCCCCc1ccc(NC(=O)NC2CCCCC2)cc1 CHEMBL2031932 IC50 1.8 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2ccc(C(F)(F)F)cn2)CC1 CHEMBL2031934 IC50 1.8 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCCCN2CCOCC2)CC1 CHEMBL2031949 IC50 1.8 nM
O=C1Cc2cc(C(=O)N3CCC4(CC3)CN(C(=O)Nc3ccc(OC(F)(F)F)cc3)CCO4)ccc2N1 CHEMBL3104437 IC50 1.8 nM
O=C(N[C@@H]1[C@@H](c2ccccc2)[C@H]1c1ccccc1)N1CCCCC1 CHEMBL3401636 IC50 1.8 nM
CC(C)COP(=O)(OCC(C)C)C(Nc1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C CHEMBL3628780 IC50 1.8 nM
CCOC(=O)C1=C(c2ccccc2)NC(=O)NC1c1ccc(NC(=O)c2ccc(OC)cc2)cc1 CHEMBL4212613 IC50 1.82 nM
O=C(CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)NS(=O)(=O)c1ccccc1 CHEMBL438838 IC50 1.9 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2cccc(C(=O)O)c2)CC1 CHEMBL244406 IC50 1.9 nM
CS(=O)(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL1668935 IC50 1.9 nM
CC(CCc1ccccc1)NC(=O)Nc1cccc(C(F)(F)F)c1F CHEMBL1818409 IC50 1.9 nM
N#Cc1ccc(C(=O)N2CCC3(CC2)CN(C(=O)Nc2ccc(C(F)(F)F)cc2)CCO3)cc1 CHEMBL3104623 IC50 1.9 nM
CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)CC23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C CHEMBL3629068 IC50 1.9 nM
CCc1ccc(NC(=O)N(CCN2CCOCC2)c2ccc3nc(N)sc3c2)cc1 CHEMBL4758156 IC50 1.9 nM
CCOC(=O)C1=C(c2ccccc2)NC(=O)NC1c1ccc(NC(=O)c2ccccc2C(=O)O)cc1 CHEMBL4203740 IC50 1.92 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)C2CCCOC2)CC1 CHEMBL4799231 Ki 1.99 nM
COC(=O)c1cccc(NC(=O)N[C@H]2CC[C@@H](Oc3ccc(F)cc3)CC2)c1 CHEMBL222161 IC50 2.0 nM
O=C(NCCCCCCCCCCCC(=O)OCc1ccccc1)NC12CC3CC(CC(C3)C1)C2 CHEMBL224449 IC50 2.0 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](OCc2ccccc2Cl)CC1 CHEMBL245255 IC50 2.0 nM
CS(=O)(=O)c1ccc2c(c1)CCC1(CCN(C(=O)c3ccc(C(F)(F)F)cc3)CC1)O2 CHEMBL497828 IC50 2.0 nM
O=C(Nc1ccc(Cl)cc1)Nc1cccc(OCCCN2CCOCC2)c1 CHEMBL564360 IC50 2.0 nM
CC(C)N1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)cc2)CC1 CHEMBL1088546 IC50 2.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)Nc1ccc(C(=O)NCCN2CCOCC2)cc1 CHEMBL1086821 IC50 2.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(C(=O)NCCN2CCOCC2)c(F)c1 CHEMBL1088420 IC50 2.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(C(=O)N2CCOCC2)c(F)c1 CHEMBL1088564 IC50 2.0 nM
COC(=O)CCc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 CHEMBL477237 IC50 2.0 nM
CCCCCOC(=O)C1CCCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)C1 CHEMBL2070332 IC50 2.0 nM
O=C(Nc1cc(C(F)(F)F)no1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2392761 IC50 2.0 nM
O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(Oc2ccccc2Cl)CC1 CHEMBL3114618 IC50 2.0 nM
COc1ccc(CNC(=O)c2ccccc2)c(C(F)(F)F)c1 CHEMBL4087689 IC50 2.0 nM
O=C(O)CNC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1 CHEMBL4211037 IC50 2.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)NCCO)cc2)CC1 CHEMBL4206149 IC50 2.0 nM
NC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1 CHEMBL4207039 IC50 2.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(O)cc2)CC1 CHEMBL4216368 IC50 2.0 nM
CCOC(=O)C1=C(c2ccccc2)NC(=O)NC1c1ccc(NC(=O)c2ccc([N+](=O)[O-])cc2)cc1 CHEMBL4205324 IC50 2.0 nM
Cc1cc(NC(=O)Nc2cccc(Cl)c2)ccc1OCc1nc2ccccc2s1 CHEMBL4584048 IC50 2.0 nM
CN(CCn1cccn1)C(=O)c1ccc(-c2cccc(C(=O)NC3CCCCC3)c2)nc1 CHEMBL4452411 IC50 2.0 nM
O=C(NC1CCC2CCCC2C1)C1CCCN(S(=O)(=O)c2cccs2)C1 CHEMBL4793243 IC50 2.0 nM
CC(C#Cc1cccc(C(=O)NCCC(c2ccccc2)c2ccccc2)c1)N(O)C(N)=O CHEMBL4764099 IC50 2.0 nM
CC(C#Cc1cccc(C(=O)NCCC(c2ccccc2)c2ccc(F)cc2)c1)N(O)C(N)=O CHEMBL4795110 IC50 2.0 nM
CC(C#Cc1cccc(C(=O)NCCC(c2ccccc2)c2ccc(Cl)cc2)c1)N(O)C(N)=O CHEMBL4759111 IC50 2.0 nM
CC(F)(F)c1ccc(C(=O)NCc2ccc(NS(C)(=O)=O)cc2Cl)cc1 CHEMBL5089068 IC50 2.0 nM
CS(=O)(=O)Cc1ccc(CNC(=O)c2ccc3c(ccn3S(=O)(=O)c3cccc(F)c3)c2)c(C(F)(F)F)c1 CHEMBL5075652 IC50 2.0 nM
CC(C)Cn1ccc2cc(C(=O)NCc3ccc(CS(=O)(=O)C4CC4)cc3C(F)(F)F)ccc21 CHEMBL5078180 IC50 2.0 nM
CC(C)S(=O)(=O)n1ccc2cc(C(=O)NCc3ccc(CS(=O)(=O)C4CC4)cc3C(F)(F)F)ccc21 CHEMBL5074984 IC50 2.0 nM
O=C(NCc1ccc(CS(=O)(=O)C2CC2)cc1C(F)(F)F)c1ccc2c(ccn2S(=O)(=O)c2cccc(F)c2)c1 CHEMBL5088299 IC50 2.0 nM
CC(C)c1ccc(Cn2ccc3cc(NC(=O)NCC45C[C@H]6C[C@@H](C4)C[C@@H](C5)C6)ccc32)cc1 CHEMBL5405712 IC50 2.0 nM
O=C(Nc1ccc(C(F)(F)F)c(F)c1)NC1CCN(C(=O)[C@@H]2CCOC2)CC1 CHEMBL4750293 Ki 2.09 nM
O=C(NC1CCN(C(=O)c2ccncc2)CC1)NC12CC3CC(CC(C3)C1)C2 CHEMBL214179 IC50 2.1 nM
CS(=O)(=O)NC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL390293 IC50 2.1 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](OCc2ccc(Br)cc2)CC1 CHEMBL242460 IC50 2.1 nM
CS(=O)(=O)c1ccc(C(CCNC(=O)c2ccc(O)nc2)c2ccc(F)cc2)cc1 CHEMBL556507 EC50 2.1 nM
O=C(CC1CC1)N1CCC2(CC1)CN(C(=O)Nc1ccc(C(F)(F)F)cc1)CCO2 CHEMBL3104439 IC50 2.1 nM
O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(Oc2ccccc2C(F)(F)F)CC1 CHEMBL3114595 IC50 2.1 nM
O=C(O)CCc1ccc(OC2CCN(C(=O)N[C@@H]3[C@@H](c4ccc(F)cc4)[C@H]3c3ccc(F)cc3)CC2)cc1 CHEMBL3401635 IC50 2.1 nM
CCC(=O)N1CCC(C(=O)NCc2ccc(OC)cc2C(F)(F)F)CC1 CHEMBL4083949 IC50 2.1 nM
C[C@H](C#Cc1cccc(C(=O)NCCC(c2ccccc2)c2ccc(Cl)c(Cl)c2)c1)N(O)C(N)=O CHEMBL4745687 IC50 2.1 nM
CCN(CC)CCN1CCC(CC(=O)N2CCCN(Cc3ccc(NC(=O)N[C@@]45C[C@@H]6C[C@@](C)(C[C@@](C)(C6)C4)C5)c(F)c3)CC2)CC1 CHEMBL5420723 IC50 2.1 nM
CCN(CC)C(=O)C1CCN(C(=O)c2ccc(NC(=O)N[C@@]34C[C@@H]5C[C@@](C)(C[C@@](C)(C5)C3)C4)c(F)c2)CC1 CHEMBL5399542 IC50 2.2 nM
CCOC(=O)C1=C(c2ccccc2)NC(=O)NC1c1ccc(NC(=O)CCC(=O)O)cc1 CHEMBL4209701 IC50 2.22 nM
CCCC(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1 CHEMBL3327063 Ki 2.23 nM
O=C(NC1CCN(c2ccccc2)CC1)N[C@H]1C[C@@H]1c1ccccc1 CHEMBL1672132 pIC50 2.291 nM
COC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL224357 IC50 2.3 nM
CCCOCCCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL245147 IC50 2.3 nM
O=C(NCCCCCOCCN1CCOCC1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2032043 IC50 2.3 nM
Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3cnc4ccccc4c3)CC2)c(C)c1 CHEMBL2313181 IC50 2.3 nM
CCC(CNC(=O)NCCCCNC(=O)NCC(CC)C12CC3CC(CC(C3)C1)C2)C12CC3CC(CC(C3)C1)C2 CHEMBL3263295 IC50 2.3 nM
O=C(O)CCc1ccc(OC2CCN(C(=O)N[C@@H]3[C@@H](c4ccccc4)[C@H]3c3ccccc3)CC2)cc1 CHEMBL3401634 IC50 2.3 nM
CC1(C)C2CCC1(C)C(NC(=O)NCCCCNC(=O)NC1CC3CCC1(C)C3(C)C)C2 CHEMBL4762498 IC50 2.3 nM
CC12CC3CC(C)(C1)CC(NC(=O)Nc1ccc(C(=O)NC4CCCCC4)cc1)(C3)C2 CHEMBL4850972 IC50 2.3 nM
COc1ccc(-c2csc(-c3ccc(NC(=O)C4CCN(S(=O)(=O)c5ccccc5Cl)CC4)cc3)n2)cc1 CHEMBL5094294 IC50 2.3 nM
Cc1cc(C(=O)Nc2ccc(Cl)cc2)ccc1N(CCN1CCCCC1)C(=O)Nc1ccc(Cl)cc1 CHEMBL5173974 IC50 2.3 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(CN4CCCC(C(=O)O)C4)cc1F)(C3)C2 CHEMBL5414609 IC50 2.3 nM
O=C(NCCCCCCCCCCCC(=O)OCc1cccc2ccccc12)NC12CC3CC(CC(C3)C1)C2 CHEMBL224579 IC50 2.4 nM
O=C(Nc1cccc(C(F)(F)F)c1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2031799 IC50 2.4 nM
O=C(Nc1ccc(OCCN2CCOCC2)cc1Cl)NC12CC3CC(CC(C3)C1)C2 CHEMBL2032046 IC50 2.4 nM
O=C(NCCCCCCCCNC(=O)NC1C2CC3CC(C2)CC1C3)NC1C2CC3CC(C2)CC1C3 CHEMBL3263302 Ki 2.4 nM
O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCN(C(=O)C2CCCOC2)CC1 CHEMBL4791464 Ki 2.4 nM
C[C@H](C#Cc1cccc(C(=O)NCCC(c2ccccc2)c2ccc(S(N)(=O)=O)cc2)c1)N(O)C(N)=O CHEMBL4745452 IC50 2.4 nM
C[C@H](C#Cc1cccc(C(=O)NCCC(c2ccc(F)cc2)c2ccc(OC(F)(F)F)cc2)c1)N(O)C(N)=O CHEMBL4755533 IC50 2.4 nM
O=C(Nc1ccc(-c2nc(-c3ccc(F)cc3)cs2)cc1)C1CCN(S(=O)(=O)c2ccccc2Cl)CC1 CHEMBL5074748 IC50 2.4 nM
CCC(C)C(=O)N1CCC(NC(=O)Nc2ccc(C(C)(C)C)cc2)CC1 CHEMBL3327072 Ki 2.44 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](OCC2CCCCC2)CC1 CHEMBL395987 IC50 2.5 nM
O=C(NC1CCC(Cc2ccc(F)cc2)CC1)NC12CC3CC(CC(C3)C1)C2 CHEMBL243522 IC50 2.5 nM
CCCOCCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL245146 IC50 2.5 nM
O=C(CC12CC3CC(CC(C3)C1)C2)Nc1cccc(OCCCN2CCOCC2)c1 CHEMBL456632 IC50 2.5 nM
O=C(NC1CCCC(OCCCN2CCOCC2)C1)NC12CC3CC(CC(C3)C1)C2 CHEMBL563709 IC50 2.5 nM
COC(=O)c1cccc(O[C@H]2CC[C@@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)c1 CHEMBL2031795 IC50 2.5 nM
CC1(C)C2CCC1(C)C(NC(=O)Nc1ccc(OC(F)(F)F)cc1)C2 CHEMBL4790175 IC50 2.5 nM
Cc1ccc(-c2csc(-c3ccc(NC(=O)C4CCN(S(=O)(=O)c5ccccc5Cl)CC4)cc3)n2)cc1 CHEMBL5076329 IC50 2.5 nM
CN(C)CCN1CCC(CC(=O)N2CCCN(Cc3ccc(NC(=O)N[C@@]45C[C@@H]6C[C@@](C)(C[C@@](C)(C6)C4)C5)c(F)c3)CC2)CC1 CHEMBL5423755 IC50 2.59 nM
CCCC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL215125 IC50 2.6 nM
CO[C@H]1CC[C@H](NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL242256 IC50 2.6 nM
CCOCCn1cc(C(=O)NCCC(c2ccccc2)c2ccccc2)ccc1=O CHEMBL567491 IC50 2.6 nM
CS(=O)(=O)c1ccc(-n2nc(CNC(=O)NC3CCCCCC3)cc2-c2ccccc2)cc1 CHEMBL1766290 IC50 2.6 nM
O=C(Nc1cccc(OC(F)F)c1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2031798 IC50 2.6 nM
O=C(NCC1CCCCC1)Nc1cccc(Cl)c1 CHEMBL2031928 IC50 2.6 nM
O=C(O)c1ccc(OC2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)c(Cl)c1 CHEMBL3114609 IC50 2.6 nM
CC(C)(C)C(Nc1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1)P(=O)(OCc1ccccc1)OCc1ccccc1 CHEMBL3628781 IC50 2.6 nM
O=C(O)CCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL5172496 IC50 2.6 nM
O=C(NCC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)Nc1ccc2c(ccn2C(=O)c2ccc(F)cc2)c1 CHEMBL5426753 IC50 2.6 nM
O=C(Nc1ccc(C(F)(F)F)c(F)c1)NC1CCN(C(=O)C2CCCOC2)CC1 CHEMBL4790379 Ki 2.66 nM
COC(=O)CCCC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL214505 IC50 2.7 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCc2ccccc2Cl)CC1 CHEMBL242900 IC50 2.7 nM
CCC(=O)N1CCC(NC(=O)N[C@H]2C[C@@H]2c2ccccc2)CC1 CHEMBL1257515 IC50 2.7 nM
CC(=O)N1CCN(CCCCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1 CHEMBL1632465 IC50 2.7 nM
O=C(Nc1cccc(C(=O)c2ccccc2)c1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2031817 IC50 2.7 nM
CC(C#Cc1cccc(C(=O)NCCC(c2ccccc2)c2ccc(C(F)(F)F)cc2)c1)N(O)C(N)=O CHEMBL4778283 IC50 2.7 nM
CS(=O)(=O)c1ccc([C@H](CCNC(=O)c2ccc(C#N)cc2)c2ccc(F)cc2)cc1 CHEMBL564227 EC50 2.8 nM
CCC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL214943 IC50 2.8 nM
CCC(=O)N1CCC(NC(=O)Nc2ccc(C(C)C)cc2)CC1 CHEMBL1257877 IC50 2.8 nM
CC(C)(C)OC(=O)N1CCN(CCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1 CHEMBL1632479 IC50 2.8 nM
CC(=O)N1CCN(CCCCCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1 CHEMBL1632477 IC50 2.8 nM
Cc1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCCC3)CC2)c(C)c1 CHEMBL2313166 IC50 2.8 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)C3CCOC3)CC2)C1 CHEMBL2436582 IC50 2.8 nM
COc1ccc(CNC(=O)c2ccc(F)cc2)c(C(F)(F)F)c1 CHEMBL4067990 IC50 2.8 nM
Nc1nc2ccc(N(CCN3CCOCC3)C(=O)Nc3ccc(Cl)cc3)cc2s1 CHEMBL4740693 IC50 2.8 nM
COC(=O)c1ccc(NC(=O)N[C@H]2CC[C@@H](Oc3ccc(F)cc3)CC2)cc1 CHEMBL438983 IC50 2.9 nM
CC(C)NC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL224395 IC50 2.9 nM
CS(=O)(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1 CHEMBL1257634 IC50 2.9 nM
CC(C)(C)OC(=O)N1CCN(CCCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1 CHEMBL1632481 IC50 2.9 nM
CC(C)(C)C(=O)N1CCC2(CC1)CN(C(=O)Nc1ccc(C(F)(F)F)cc1)CCO2 CHEMBL3104438 IC50 2.9 nM
COc1ccc(CNC(=O)c2cccc(NC(C)=O)c2)c(C(F)(F)F)c1 CHEMBL4095377 IC50 2.9 nM
CCC(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)c(F)c2)CC1 CHEMBL4795460 Ki 2.94 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(C(=O)NC4CCC(C(=O)N(CCO)CCO)CC4)cc1F)(C3)C2 CHEMBL5425040 IC50 2.94 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCCN(C(=O)c3c(F)cccc3F)C2)CC1 CHEMBL3104616 IC50 2.96 nM
O=C1CC2(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)Oc2ccccc21 CHEMBL496189 IC50 3.0 nM
Cn1nccc1Nc1ccc2c(c1)C(=O)CC1(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC1)O2 CHEMBL495793 IC50 3.0 nM
O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC2(CCc3cc(F)ccc3O2)CC1 CHEMBL483876 IC50 3.0 nM
CS(=O)(=O)c1ccc2c(c1)CCC1(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC1)O2 CHEMBL519336 IC50 3.0 nM
CS(=O)(=O)c1ccc2c(c1)CCC1(CCCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC1)O2 CHEMBL482637 IC50 3.0 nM
O=C(CCc1ccccc1)N1CCC2(CCc3cc(F)ccc3O2)CC1 CHEMBL447085 IC50 3.0 nM
N#CCCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1 CHEMBL1078755 IC50 3.0 nM
CCN(CC)C(=O)CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1 CHEMBL1078628 IC50 3.0 nM
O=C(Nc1ccc(C(=O)NCCN2CCOCC2)cc1)NC12CC3CC(CC(C3)C1)C2 CHEMBL1088700 IC50 3.0 nM
O=C(Nc1ccc(C(=O)NCC(=O)N2CCOCC2)cc1)Nc1ccc(C(F)(F)F)cc1 CHEMBL1087492 IC50 3.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(S(=O)(=O)NCCN2CCOCC2)cc1 CHEMBL1088351 IC50 3.0 nM
CC(C)N1CCN(S(=O)(=O)c2cccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)c2)CC1 CHEMBL1088228 IC50 3.0 nM
O=C(NCCC(c1ccc(F)cc1)c1ccc(F)cc1)N1CCC(c2cnccn2)C1 CHEMBL1085743 IC50 3.0 nM
CCC(=O)N1CCC(NC(=O)Nc2ccc3ccccc3c2)CC1 CHEMBL1257516 IC50 3.0 nM
CCCCC(CC)OC(=O)C1CCCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)C1 CHEMBL2070333 IC50 3.0 nM
O=C(Nc1nc2ccccc2s1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2392723 IC50 3.0 nM
CNc1nc(C)nc(N2CCC(C(=O)NCc3ccc(F)cc3C(F)(F)F)CC2)n1 CHEMBL2392690 IC50 3.0 nM
CNc1nc(C)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1 CHEMBL2392714 IC50 3.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)C3CCOCC3)CC2)C1 CHEMBL2436583 IC50 3.0 nM
O=C(NC1CCCCC1)NC1CCCCC1 CHEMBL1458 IC50 3.0 nM
CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)C2CCc3ccccc3C2)cc1)C(C)(C)C CHEMBL3629063 IC50 3.0 nM
CCCCOP(=O)(OCCCC)C(Nc1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C CHEMBL3628779 IC50 3.0 nM
COc1ccc(CNC(=O)c2ccc3c(c2)NC(=O)C3)c(C(F)(F)F)c1 CHEMBL4063138 IC50 3.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)OCc3ccccc3)cc2)CC1 CHEMBL4215208 IC50 3.0 nM
COc1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1 CHEMBL4211405 IC50 3.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(CO)cc2)CC1 CHEMBL4203223 IC50 3.0 nM
COC(=O)CNC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1 CHEMBL4209593 IC50 3.0 nM
C[C@H](C#Cc1cccc(C(=O)NCCC(c2ccccc2)c2ccc(NS(C)(=O)=O)cc2)c1)N(O)C(N)=O CHEMBL4759652 IC50 3.0 nM
C[C@H](C#Cc1cccc(C(=O)NCC[C@@H](c2ccc(F)cc2)c2ccc(C(F)(F)F)cc2)c1)N(O)C(N)=O CHEMBL4751593 IC50 3.0 nM
C[C@H](C#Cc1cccc(C(=O)NCC[C@H](c2ccc(F)cc2)c2ccc(C(F)(F)F)cc2)c1)N(O)C(N)=O CHEMBL4794423 IC50 3.0 nM
CNc1nc(NC2CCCC(C(=O)NCc3ccccc3C(F)(F)F)C2)nc(N2CCN(C)CC2)n1 CHEMBL4637413 IC50 3.0 nM
CNc1nc(NCc2cc(C(=O)NCc3ccccc3C(F)(F)F)oc2C)nc(N2CCN(C)CC2)n1 CHEMBL4870025 IC50 3.0 nM
CCS(=O)(=O)Nc1ccc(CNC(=O)c2ccc3c(ccn3Cc3cccc(F)c3)c2)c(C(F)(F)F)c1 CHEMBL5084314 IC50 3.0 nM
CC(c1cccc(F)c1)n1ccc2cc(C(=O)NCc3ccc(CS(C)(=O)=O)cc3C(F)(F)F)ccc21 CHEMBL5079563 IC50 3.0 nM
O=C(NCc1ccc(CS(=O)(=O)C2CC2)cc1C(F)(F)F)c1ccc2c(ccn2CC2CC2)c1 CHEMBL5081457 IC50 3.0 nM
O=C(NCc1ccc(CS(=O)(=O)C2CC2)cc1C(F)(F)F)c1ccc2c(ccn2CC(C(F)(F)F)C(F)(F)F)c1 CHEMBL5090087 IC50 3.0 nM
COCCn1ccc2cc(C(=O)NCc3ccc(CS(=O)(=O)C4CC4)cc3C(F)(F)F)ccc21 CHEMBL5074074 IC50 3.0 nM
COC(=O)CCCc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 CHEMBL514369 IC50 3.1 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)Cc2ccccn2)CC1 CHEMBL1257285 IC50 3.1 nM
O=C(Nc1cccc(OC(F)(F)F)c1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2031791 IC50 3.1 nM
Cc1ccccc1OC1CCN(C(=O)N[C@H]2C[C@@H]2c2ccccc2)CC1 CHEMBL3114592 IC50 3.1 nM
CC(=O)N1CCC(NC(=O)NC23CC4CC(C)(CC(C2)c2ccccc24)C3)CC1 CHEMBL5081815 IC50 3.1 nM
O=C(Nc1ccc(-c2nc(-c3ccccc3)cs2)cc1)C1CCN(S(=O)(=O)c2ccccc2Cl)CC1 CHEMBL5082839 IC50 3.1 nM
CC1=C[C@H]2Cc3nc4cc(Cl)ccc4c(NCCCCC(=O)N4CCC(NC(=O)Nc5ccc(OC(F)(F)F)cc5)CC4)c3[C@@H](C1)C2 CHEMBL5188116 IC50 3.1 nM
CC[C@H](C)C(=O)N1CCC(CC(=O)Nc2ccc(OC(F)(F)F)c(F)c2)CC1 CHEMBL4763290 Ki 3.14 nM
O=C(NCC1CCN(C(=O)c2ccccc2)CC1)NC12CC3CC(CC(C3)C1)C2 CHEMBL214883 IC50 3.2 nM
CCCCCCCCNC(=O)NC1CCN(C(=O)CC)CC1 CHEMBL1257514 IC50 3.2 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3ccccc3)CC2)C1 CHEMBL3104618 IC50 3.2 nM
O=C(Nc1ccc(F)c(F)c1F)NC12CC3CC1CC3C2 CHEMBL4448746 IC50 3.2 nM
O=C(NC1CCN(C(=O)c2ccc(C(=O)O)cc2)CC1)NC12CC3CC(CC(C3)C1)C2 CHEMBL386384 IC50 3.3 nM
CC(=O)N1CCN(CCCOc2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)CC1 CHEMBL1632460 IC50 3.3 nM
Cc1ccc(S(=O)(=O)N2CCN(CCCCOc3cccc(NC(=O)NC45CC6CC(CC(C6)C4)C5)c3)CC2)cc1 CHEMBL1632487 IC50 3.3 nM
O=C(Nc1ccc(OCCOCCOCC(F)(F)F)cc1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2031943 IC50 3.3 nM
O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(Oc2ccc(-c3nn[nH]n3)cc2)CC1 CHEMBL3114608 IC50 3.3 nM
O=C(Nc1ccc(F)c(F)c1F)NC12CC3CC(CC1C3)C2 CHEMBL4458692 IC50 3.3 nM
CC[C@H](C)C(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)c(Cl)c2)CC1 CHEMBL4799241 Ki 3.35 nM
COC(=O)CCCC(=O)N1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL384075 IC50 3.4 nM
Cc1ccccc1CO[C@H]1CC[C@@H](NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL397426 IC50 3.4 nM
CCC(=O)N1CCC(NC(=O)Nc2ccc(Cl)c(Cl)c2)CC1 CHEMBL1258557 IC50 3.4 nM
CS(=O)(=O)c1ccc(-n2nc(CCCNC(=O)Nc3cccc(C(F)(F)F)c3)cc2-c2ccccc2)cc1 CHEMBL1766300 IC50 3.4 nM
Cc1cc(NC(=O)N2CCC3(CCN(C(=O)c4c(F)cccc4F)CC3)C2)ccc1Cl CHEMBL2436570 IC50 3.4 nM
CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)Cc2ccc3ccccc3c2)cc1)C(C)(C)C CHEMBL3629069 IC50 3.4 nM
CCOC(=O)c1ccc(O[C@H]2CC[C@@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1 CHEMBL3677973 IC50 3.4 nM
CC(=O)N1CCC(NC(=O)NC2C3CC4C5CC6CC4C2C(C6)C5C3)CC1 CHEMBL4530604 IC50 3.4 nM
O=C(NCCCCNC(=O)NCCC12CC3CC(CC(C3)C1)C2)NCCC12CC3CC(CC(C3)C1)C2 CHEMBL4644608 IC50 3.4 nM
CC[C@H](C)C(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)c(Br)c2)CC1 CHEMBL4763640 Ki 3.4 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(C(=O)N4CCC(C(=O)NCCO)CC4)cc1F)(C3)C2 CHEMBL5397730 IC50 3.43 nM
O=C(CC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCc2c(F)cccc2F)CC1 CHEMBL245225 IC50 3.5 nM
CC(C)Oc1cc(F)c(CO[C@H]2CC[C@@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)c(F)c1 CHEMBL242026 IC50 3.5 nM
CC(C)Oc1cc(F)c(CO[C@H]2CC[C@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)c(F)c1 CHEMBL397693 IC50 3.5 nM
CCC(=O)N1CCC(NC(=O)Nc2ccc(Oc3ccccc3)cc2)CC1 CHEMBL1257879 IC50 3.5 nM
O=C(Nc1ccc(Cl)c(Cl)c1)N1CCC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1 CHEMBL2436569 IC50 3.5 nM
CCC(=O)N1CCC(NC(=O)Nc2ccc(Br)cc2)CC1 CHEMBL1258336 IC50 3.6 nM
CC(=O)N1CCN(CCCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1 CHEMBL1632457 IC50 3.6 nM
CC12CC3CC(C)(C1)CC(NC(=O)Nc1ccccc1F)(C3)C2 CHEMBL4649528 IC50 3.6 nM
CCCOCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL245144 IC50 3.7 nM
CS(=O)(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1 CHEMBL1668936 IC50 3.7 nM
O=C(NCc1cccc(Cl)c1)Nc1cccc(C(F)(F)F)c1F CHEMBL1818410 IC50 3.7 nM
CCC(=O)Nc1cccc(C(=O)NCc2ccc(OC)cc2C(F)(F)F)c1 CHEMBL4078857 IC50 3.7 nM
CC1(C)[C@H]2CC[C@]1(C)C(NC(=O)Nc1ccccc1F)C2 CHEMBL4778603 IC50 3.7 nM
CC(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1 CHEMBL1668934 IC50 3.7 nM
COCC(=O)c1ccc(O[C@H]2CC[C@@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)cc1 CHEMBL2031933 IC50 3.8 nM
COC(=O)c1ccc(NC(=O)N[C@H]2CC[C@@H](Oc3cc(C(=O)OC)cc(C(=O)OC)c3)CC2)cc1 CHEMBL2031935 IC50 3.8 nM
CC(C)(C)C(Nc1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1)P(=O)(OCC(F)(F)F)OCC(F)(F)F CHEMBL3628777 IC50 3.8 nM
O=C1C(=O)N(C23CC4CC(CC(C4)C2)C3)C(=O)N1CCCCCCCCN1C(=O)C(=O)N(C23CC4CC(CC(C4)C2)C3)C1=O CHEMBL4644920 IC50 3.8 nM
O=C(Nc1ccc(C(F)(F)F)c(F)c1)NC1CCN(C(=O)C2CCOCC2)CC1 CHEMBL4777697 Ki 3.83 nM
O=C(NCCCCOc1ccc(F)cc1)NC12CC3CC(CC(C3)C1)C2 CHEMBL387810 IC50 3.9 nM
CC(=O)Oc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 CHEMBL476058 IC50 3.9 nM
O=C(Nc1cccc(OCCCN2CCOCC2)c1)NC1CCCCC1 CHEMBL458166 IC50 3.9 nM
CCC(=O)N1CCC(NC(=O)NC2CCCCCC2)CC1 CHEMBL1257632 IC50 3.9 nM
CC(C)(C)c1ccc(NC(=O)NC2CCCCC2)cc1 CHEMBL2029374 IC50 3.9 nM
CC(NC(=O)Nc1ccc(C(=O)N2CCCCC2)cc1)C12CC3CC(CC(C3)C1)C2 CHEMBL4859241 IC50 3.9 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCC2CCCCC2)CC1 CHEMBL397669 IC50 4.0 nM
CO[C@H]1CC[C@@H](NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL242470 IC50 4.0 nM
COC(=O)Cc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 CHEMBL477238 IC50 4.0 nM
Cn1nccc1-c1ccc2c(c1)C(=O)CC1(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC1)O2 CHEMBL495792 IC50 4.0 nM
CS(=O)(=O)c1ccc2c(c1)C(=O)CC1(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC1)O2 CHEMBL495794 IC50 4.0 nM
O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC2(CCc3ccccc3O2)CC1 CHEMBL495995 IC50 4.0 nM
O=C(c1ccc(C(F)(F)F)cc1)N1CCC2(CCc3ccccc3O2)CC1 CHEMBL524992 IC50 4.0 nM
O=C1CC2(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)Oc2cccnc21 CHEMBL495993 IC50 4.0 nM
CS(=O)(=O)c1ccc(-c2noc(C3CCN(C(=O)NC4CC4c4ccccc4)CC3)n2)cc1 CHEMBL551058 IC50 4.0 nM
FC(F)(F)c1ccc(Nc2noc3c(C(F)(F)F)cccc23)cc1 CHEMBL577695 IC50 4.0 nM
FC(F)(F)c1ccc(Nc2noc3c(-c4ccccc4C(F)(F)F)cccc23)cc1 CHEMBL578548 IC50 4.0 nM
CC(C)N1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2)CC1 CHEMBL1088547 IC50 4.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)Nc1ccc(C(=O)N2CCOCC2)cc1 CHEMBL1087491 IC50 4.0 nM
CN1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)cc2F)CC1 CHEMBL1086851 IC50 4.0 nM
O=C(NCc1ccccc1OC(F)(F)F)N1CCC(Oc2ncccn2)CC1 CHEMBL1082684 IC50 4.0 nM
CCCCC(C)OC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL2070327 IC50 4.0 nM
CCCCC(CC)OC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL2070328 IC50 4.0 nM
CCOCCOCC(OC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2)c1ccccc1 CHEMBL2031796 IC50 4.0 nM
CCc1nc(NC)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1 CHEMBL2392715 IC50 4.0 nM
CCCC(=O)N1CCC(C(=O)NCc2ccc(OC)cc2C(F)(F)F)CC1 CHEMBL4101942 IC50 4.0 nM
CC(=O)Oc1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1 CHEMBL4211919 IC50 4.0 nM
Cc1nnc(-c2ccc(O[C@H]3CC[C@H](NC(=O)Nc4ccc(OC(F)(F)F)cc4)CC3)cc2)o1 CHEMBL4214874 IC50 4.0 nM
O=Cc1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1 CHEMBL4204023 IC50 4.0 nM
COc1ccc(CNC(=O)c2cccc(C#CC(C)N(O)C(N)=O)c2)c(C(F)(F)F)c1 CHEMBL4791222 IC50 4.0 nM
CS(=O)(=O)Nc1ccc(CNC(=O)c2ccc(C(F)(F)C(F)(F)F)cc2)c(Cl)c1 CHEMBL5086882 IC50 4.0 nM
CS(=O)(=O)Cc1ccc(CNC(=O)c2ccc3c(ccn3C(=O)c3cccc(F)c3)c2)c(C(F)(F)F)c1 CHEMBL5090873 IC50 4.0 nM
O=C(Cc1ccccc1F)Nc1nc2ccc(N(CCN3CCOCC3)C(=O)Nc3ccc(Cl)cc3)cc2s1 CHEMBL4787307 IC50 4.08 nM
COC(=O)c1cccc(C(=O)N2CCC(CNC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)c1 CHEMBL215121 IC50 4.1 nM
CCCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL245142 IC50 4.1 nM
COC(=O)c1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 CHEMBL478505 IC50 4.1 nM
CCC(=O)N1CCC(NC(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)CC1 CHEMBL1258669 IC50 4.1 nM
NS(=O)(=O)c1ccc(-n2nc(CCCNC(=O)Nc3cccc(C(F)(F)F)c3)cc2-c2ccccc2)cc1 CHEMBL1766299 IC50 4.1 nM
CC(C)OCCOCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL2031946 IC50 4.1 nM
CC12CC3CC(C)(C1)CC(NC(=O)NCc1cc(-c4ccco4)on1)(C3)C2 CHEMBL3633681 IC50 4.1 nM
Cc1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCc1nc2ccccc2s1 CHEMBL4474511 IC50 4.1 nM
Nc1nc2ccc(NC(=O)NC3CCCCC3)cc2s1 CHEMBL4798443 IC50 4.1 nM
O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Oc2ccc(F)cc2)CC1 CHEMBL590106 EC50 4.2 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3ccccn3)CC2)C1 CHEMBL3104434 IC50 4.2 nM
CCNC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL224580 IC50 4.3 nM
O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Oc2ccccc2)CC1 CHEMBL589135 IC50 4.3 nM
O=C(O)Cc1ccc(OC2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)c(Cl)c1 CHEMBL3114610 IC50 4.3 nM
CS(=O)(=O)Nc1ccc(CNC(=O)c2ccc(C3(C(F)(F)F)CC3)cc2)c(Cl)c1 CHEMBL5092609 IC50 4.3 nM
CCCCCOCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL191767 IC50 4.4 nM
CON(C)C(=O)C(=O)N(C)c1ccc(NC(=O)CC23CC4CC(CC(C4)C2)C3)cc1 CHEMBL3103817 IC50 4.4 nM
O=C(NCC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)Nc1ccc2c(ccn2-c2ccc(F)cc2)c1 CHEMBL5420193 IC50 4.4 nM
Cc1c(Cl)cccc1NC(=O)NC1C2CC3CC(C2)CC1C3 CHEMBL1818397 IC50 4.5 nM
O=C(NCCc1ccccc1)NC1C2CC3CC(C2)CC1C3 CHEMBL1818394 IC50 4.5 nM
O=C(NC1CCCCCC1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1 CHEMBL4642519 IC50 4.5 nM
CC(O)CNC(=O)C1CCN(C(=O)c2ccc(NC(=O)N[C@@]34C[C@@H]5C[C@@](C)(C[C@@](C)(C5)C3)C4)c(F)c2)CC1 CHEMBL5396859 IC50 4.5 nM
O=C(NCc1ccccc1OC(F)(F)F)c1ccc(OCCC(F)(F)F)nc1 CHEMBL567110 IC50 4.6 nM
Cc1ccc(S(=O)(=O)N2CCC(C(=O)NC3CC3)CC2)c(C)c1 CHEMBL2313162 IC50 4.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)CCCCNc2c3c(nc4cc(Cl)ccc24)CCCC3)CC1 CHEMBL5178885 IC50 4.6 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(C(=O)N4CCCC(C(=O)O)C4)cc1F)(C3)C2 CHEMBL5414179 IC50 4.6 nM
COc1cccc2c1CC(C(=O)N[C@H]1C[C@@H]1c1ccccc1)CC2 CHEMBL1672128 pIC50 4.677 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(CN4CCCN(C(=O)CC5CCN(CCO)CC5)CC4)cc1F)(C3)C2 CHEMBL5410982 IC50 4.69 nM
COc1cccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1 CHEMBL516890 IC50 4.7 nM
O=C(Nc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)cn1)c1ccccc1 CHEMBL1271608 IC50 4.7 nM
O=C(Nc1ccc(CC(=O)c2ccccc2)cc1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2031940 IC50 4.7 nM
CC(C)C(=O)N1CCC(CC(=O)Nc2ccc(OC(F)(F)F)c(F)c2)CC1 CHEMBL4797107 Ki 4.72 nM
O=C(Nc1ccc(Cl)cc1)Nc1ccc(F)c(OCCCN2CCOCC2)c1 CHEMBL550655 IC50 4.8 nM
Fc1ccc(NC(=S)NC2C3CC4CC(C3)CC2C4)c(F)c1F CHEMBL1818411 IC50 4.8 nM
O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(C(F)(F)F)cn2)CC1 CHEMBL2031794 IC50 4.8 nM
O=C(NCc1cc(-c2ccco2)on1)NCC12CC3CC(CC(C3)C1)C2 CHEMBL3633668 IC50 4.9 nM
CC(=O)N1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL215025 IC50 5.0 nM
O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC2(CCc3ncccc3O2)CC1 CHEMBL522211 IC50 5.0 nM
O=C1CC2(CCN(C(=O)NC3CCc4ccccc4C3)CC2)Oc2ccccc21 CHEMBL495601 IC50 5.0 nM
O=C(O)c1ccc(-c2noc(C3CCN(C(=O)NC4CC4c4ccccc4)CC3)n2)cc1 CHEMBL559531 IC50 5.0 nM
O=C(NCCC(c1ccc(F)cc1)c1ccc(F)cc1)c1ccc(O)nc1 CHEMBL563417 IC50 5.0 nM
O=C(NCCC(c1ccc(F)cc1)c1ccc(F)cc1)c1ccc(OCC(F)(F)F)nc1 CHEMBL560740 IC50 5.0 nM
O=C(NCCC(c1ccc(F)cc1)c1ccc(F)cc1)c1ccnc(OCC(F)(F)F)c1 CHEMBL564893 IC50 5.0 nM
N#Cc1ccc(C(=O)NCCC(c2ccc(F)cc2)c2ccc(F)cc2)cc1 CHEMBL551138 IC50 5.0 nM
CS(=O)(=O)c1ccc(C(=O)NCCC(c2ccc(F)cc2)c2ccc(F)cc2)cc1 CHEMBL551338 IC50 5.0 nM
CC1(c2ccccc2)CCCN(C(=O)NCCc2ccc3nccnc3c2)C1 CHEMBL1078452 IC50 5.0 nM
O=C(O)CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1 CHEMBL1079256 IC50 5.0 nM
O=C(O)CCCCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1 CHEMBL1078657 IC50 5.0 nM
NC(=O)CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1 CHEMBL1079292 IC50 5.0 nM
O=C(Nc1ccc(Cl)cc1)N1CCCC(CCC2=NNNN2)(c2ccccc2)C1 CHEMBL1079244 IC50 5.0 nM
CNC(=O)CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1 CHEMBL1079246 IC50 5.0 nM
O=C(O)CCC1(c2ccc(C(F)(F)F)cc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1 CHEMBL1078715 IC50 5.0 nM
O=C(Nc1ccc(C(=O)N2CCOCC2)cc1)Nc1ccc(C(F)(F)F)cc1 CHEMBL1087490 IC50 5.0 nM
CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)cc2)CC1 CHEMBL1088350 IC50 5.0 nM
Cc1cc(NC(=O)NC2C3CC4CC(C3)CC2C4)no1 CHEMBL2392735 IC50 5.0 nM
CNc1cc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)nc(C)n1 CHEMBL2392701 IC50 5.0 nM
CON(C)C(=O)C(=O)Nc1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 CHEMBL3103820 IC50 5.0 nM
CC(C)OC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1 CHEMBL4213817 IC50 5.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)NCc3ccccc3)cc2)CC1 CHEMBL4214503 IC50 5.0 nM
CC(C)CC(C#Cc1cccc(C(=O)NCc2ccccc2C(F)(F)F)c1)N(O)C(N)=O CHEMBL4746544 IC50 5.0 nM
C[C@H](C#Cc1cccc(C(=O)NCCN(c2ccccc2)c2ccccc2)c1)N(O)C(N)=O CHEMBL4747688 IC50 5.0 nM
CS(=O)(=O)Nc1ccc(CNC(=O)c2ccc3c(ccn3Cc3cccc(F)c3)c2)c(C(F)(F)F)c1 CHEMBL5090821 IC50 5.0 nM
O=C(NCc1ccc(NC(=O)C(F)(F)F)cc1C(F)(F)F)c1ccc2c(ccn2Cc2cccc(F)c2)c1 CHEMBL5087833 IC50 5.0 nM
CC(C)n1ccc2cc(C(=O)NCc3ccc(CS(=O)(=O)C4CC4)cc3C(F)(F)F)ccc21 CHEMBL5081013 IC50 5.0 nM
O=C(NCc1ccc(CS(=O)(=O)C2CC2)cc1C(F)(F)F)c1ccc2c(ccn2CC2COC2)c1 CHEMBL5091134 IC50 5.0 nM
O=C(Nc1cccc(OC(=O)c2ccccc2)c1)NC12CC3CC(CC(C3)C1)C2 CHEMBL476057 IC50 5.1 nM
O=C(NCCC(c1ccccc1)c1ccccc1)c1ccccc1 CHEMBL556303 IC50 5.1 nM
CCOCCOCCOc1ccc(C(OC(=O)CCCNC(=O)NC23CC4CC(CC(C4)C2)C3)c2ccccc2)cc1 CHEMBL2031942 IC50 5.1 nM
O=C(Nc1ccc(O)c(Cl)c1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2031806 IC50 5.1 nM
CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C CHEMBL3628769 IC50 5.1 nM
O=C(CC12CC3CC(CC(C3)C1)C2)NC1CCCC(OCCCN2CCOCC2)C1 CHEMBL561665 IC50 5.2 nM
O=C(Nc1ccc(N2CCOCC2)cc1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2032041 IC50 5.2 nM
Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc4c(c3)OCO4)CC2)c(C)c1 CHEMBL2313161 IC50 5.2 nM
Cc1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCCC3)CC2)c(C)c1 CHEMBL2313186 IC50 5.2 nM
Cc1cc(OCc2nc3ccccc3s2)ccc1NC(=O)Nc1ccc(Cl)cc1 CHEMBL4513805 IC50 5.2 nM
O=C(NCC1CCN(C(=O)c2cccnc2)CC1)NC12CC3CC(CC(C3)C1)C2 CHEMBL425436 IC50 5.4 nM
O=C(Nc1ccc(OCCCN2CCOCC2)cc1)NC1CCCCC1 CHEMBL568915 IC50 5.4 nM
O=C(NCCC(c1ccccc1)c1ccccc1)c1ccc(OCC(F)(F)F)nc1 CHEMBL565628 IC50 5.4 nM
CC(=O)N1CCN(C(=O)CCCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1 CHEMBL1632472 IC50 5.4 nM
O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccc(F)cc2Br)CC1 CHEMBL1933515 IC50 5.4 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3ccco3)CC2)C1 CHEMBL3104430 IC50 5.4 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CC1)CN(C(=O)c1c(F)cccc1F)CCO2 CHEMBL3104445 IC50 5.4 nM
CCc1ccc(NC(=O)N(CCN2CCOCC2)c2ccc3nc(NC(=O)Cc4ccccc4F)sc3c2)cc1 CHEMBL4780833 IC50 5.4 nM
O=C(Nc1ccc(Cl)cc1)NC1CCC(Oc2ccc(C(=O)O)cc2)CC1 CHEMBL3946854 IC50 5.5 nM
CCCCCCOCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL245127 IC50 5.6 nM
O=C(NCc1ccc(Cl)cc1Cl)N1CCC(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL592740 IC50 5.6 nM
O=C(Nc1ccc(OCC(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1 CHEMBL2436565 IC50 5.7 nM
CC(=O)Oc1cccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1 CHEMBL476056 IC50 5.8 nM
Cc1ccc(S(=O)(=O)N2CCC(C(=O)NCC3CCCCC3)CC2)c(C)c1 CHEMBL2313188 IC50 5.8 nM
O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Oc2ccc(Cl)cc2)CC1 CHEMBL589621 IC50 5.9 nM
O=C(NCc1ccc(Cl)cc1Cl)N1CCN(c2ccccn2)CC1 CHEMBL606035 IC50 6.0 nM
CC(=O)N1CCN(CCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1 CHEMBL1632478 IC50 6.0 nM
CC(=O)N1CCC(NC(=O)NC2CCC(C)(C)CC2)CC1 CHEMBL1668930 IC50 6.0 nM
CS(=O)(=O)c1ccc(-n2nc(CNC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2ccccc2)cc1 CHEMBL1766292 IC50 6.0 nM
Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3cccc4cccnc34)CC2)c(C)c1 CHEMBL2313203 IC50 6.0 nM
C[C@]12CC[C@@H]3c4ccc(O)cc4C[C@@H](CCCCCCCCC[S+]([O-])CCCC(F)(F)C(F)(F)F)[C@H]3[C@@H]1CC[C@@H]2O CHEMBL1358 IC50 6.0 nM
CCCCCNC(=O)NCCCC/C=C\CCCCCSc1ccccc1O CHEMBL3322807 IC50 6.0 nM
O=C(NC1CCCCC1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1 CHEMBL4217146 IC50 6.0 nM
CNc1nc(N2CCN(C)CC2)nc(N2CCCc3cc(C(=O)NCc4ccccc4C(F)(F)F)ccc32)n1 CHEMBL4871885 IC50 6.0 nM
CSCc1ccc(CNC(=O)c2ccc3c(ccn3Cc3cccc(F)c3)c2)c(C(F)(F)F)c1 CHEMBL5087046 IC50 6.0 nM
CS(=O)(=O)Cc1ccc(CNC(=O)c2ccc3c(ccn3Cc3cccc(F)c3)c2)c(C(F)(F)F)c1 CHEMBL5080474 IC50 6.0 nM
CS(=O)(=O)Cc1ccc(CNC(=O)c2ccc3c(ccn3Cc3cccc(F)c3)c2)c(Cl)c1 CHEMBL5094953 IC50 6.0 nM
CCn1ccc2cc(C(=O)NCc3ccc(CS(=O)(=O)C4CC4)cc3C(F)(F)F)ccc21 CHEMBL5092964 IC50 6.0 nM
CC(O)CNC(=O)C1CCN(Cc2ccc(NC(=O)N[C@@]34C[C@@H]5C[C@@](C)(C[C@@](C)(C5)C3)C4)c(F)c2)CC1 CHEMBL5423765 IC50 6.0 nM
Cc1cccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1 CHEMBL2031801 IC50 6.1 nM
O=C(NC1CCCC(C(=O)N2CCC(N3CCOCC3)CC2)C1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2032042 IC50 6.1 nM
CC(C)c1noc(C2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)n1 CHEMBL1615216 IC50 6.1 nM
CCS(=O)(=O)Nc1ccc(CNC(=O)c2ccc(C(C)(C)C)cc2)c(Cl)c1 CHEMBL5092029 IC50 6.1 nM
COC(=O)CCC(=O)N1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL217711 IC50 6.2 nM
CCCC(C)OCCOCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL2031947 IC50 6.2 nM
CC(=O)c1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 CHEMBL2031804 IC50 6.3 nM
O=C(NC1CCCCC1)NC1CCN(C(=O)c2ccccn2)CC1 CHEMBL1668938 IC50 6.4 nM
CCCCCNC(=O)NC1C2CC3CC(C2)CC1C3 CHEMBL1818400 IC50 6.4 nM
O=C(Nc1ccc(F)c(OCCCN2CCOCC2)c1)NC1CCCCC1 CHEMBL549902 IC50 6.5 nM
CC(C)CCOc1ccc(NC(=O)Nc2ccc(OCCC(C)C)cc2)cc1 CHEMBL1818420 IC50 6.5 nM
Cc1cc(NC(=O)Nc2ccccc2)ccc1OCc1nc2ccccc2s1 CHEMBL4467433 IC50 6.5 nM
CC(=O)N1CCC(NC(=O)NC23CC4(C)CC2CC4(C)C3)CC1 CHEMBL4516638 IC50 6.5 nM
CCCCCCCCNC(=O)NC1CC2CCC1(C)C2(C)C CHEMBL4799688 IC50 6.5 nM
Nc1nc2ccc(N(CCN3CCCCC3)C(=O)Nc3ccc(Cl)cc3)cc2s1 CHEMBL4744612 IC50 6.5 nM
Cc1cc(C(=O)Nc2ccc3c(c2)OCO3)ccc1N(CCN1CCCC1)C(=O)Nc1ccc(Cl)cc1 CHEMBL5176017 IC50 6.5 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(CN4CCC(C(=O)NC(CO)(CO)CO)CC4)cc1F)(C3)C2 CHEMBL5433624 IC50 6.51 nM
O=C(CC12CC3CC(CC(C3)C1)C2)Nc1ccc(F)c(OCCCN2CCOCC2)c1 CHEMBL551806 IC50 6.6 nM
O=C(NCc1ccc(Cl)cc1Cl)c1ccc(OCC(F)(F)F)nc1 CHEMBL572205 IC50 6.6 nM
CONC(=O)C(=O)Nc1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 CHEMBL3103818 IC50 6.6 nM
O=C(CC1CCN(C(=O)C2CC2)CC1)Nc1ccc(OC(F)(F)F)c(F)c1 CHEMBL4781646 Ki 6.6 nM
CCCC(=O)N1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL214675 IC50 6.7 nM
O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccccc2Br)CC1 CHEMBL1933497 IC50 6.7 nM
Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc(C(C)C)cc3)CC2)c(C)c1 CHEMBL2313175 IC50 6.7 nM
O=C(Nc1ccc(Cl)cc1)N1CCC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1 CHEMBL2436562 IC50 6.7 nM
CC(C)OP(=O)(OC(C)C)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C CHEMBL3628772 IC50 6.7 nM
Cc1cc(CNC(=O)NCC23CC4CC(CC(C4)C2)C3)on1 CHEMBL3633669 IC50 6.7 nM
O=C(NCCN(CCNC(=O)NCC12CC3CC(CC(C3)C1)C2)CCNC(=O)NCC12CC3CC(CC(C3)C1)C2)NCC12CC3CC(CC(C3)C1)C2 CHEMBL4646845 IC50 6.7 nM
O=C(Cn1cc(C(=O)C(F)(F)F)c2cc(Br)ccc21)NC1CCCCCC1 CHEMBL5409600 IC50 6.7 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(CN4CCC(C(=O)N(CCO)CCO)CC4)cc1F)(C3)C2 CHEMBL5412026 IC50 6.72 nM
CC(C)(C)OC(=O)N1CCN(CCCOc2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c3cccnc23)CC1 CHEMBL3222121 IC50 6.8 nM
O=C(Nc1ccccc1F)NC1CC2CCC1C2 CHEMBL4748031 IC50 6.8 nM
Cc1cc(C(=O)Nc2ccc(C(F)(F)F)nc2)ccc1N(CCN1CCOCC1)C(=O)Nc1ccc(Cl)cc1 CHEMBL5188028 IC50 6.8 nM
Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c(C)c1 CHEMBL2313167 IC50 6.9 nM
CC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL436774 IC50 7.0 nM
CS(=O)(=O)c1ccc2c(c1)C(=O)CC1(CCN(C(=O)N[C@@H]3CC[C@@H](c4ccccc4)C3)CC1)O2 CHEMBL495586 IC50 7.0 nM
O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3ccccc3C(F)(F)F)no2)CC1 CHEMBL561788 IC50 7.0 nM
O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3cccnc3)no2)CC1 CHEMBL564757 IC50 7.0 nM
O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL551921 IC50 7.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC(c2nc(-c3ccccn3)no2)CC1 CHEMBL555347 IC50 7.0 nM
O=C(NCCC(c1ccccc1)c1ccccc1)c1cccnc1 CHEMBL560537 IC50 7.0 nM
CC1(c2ccccc2)CCCN(C(=O)Nc2ccc(-c3ccccc3)cc2)C1 CHEMBL1080076 IC50 7.0 nM
CC1(c2ccccc2)CCCN(C(=O)NCc2ccc(-c3ccc4[nH]ccc4c3)cc2)C1 CHEMBL1078264 IC50 7.0 nM
CC1(c2ccccc2)CCCN(C(=O)NCCCc2cccnc2)C1 CHEMBL1078353 IC50 7.0 nM
CN1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2)CC1 CHEMBL1088545 IC50 7.0 nM
O=C(NCc1ccccc1OC(F)(F)F)N1CCC(c2ccncc2)C1 CHEMBL1085745 IC50 7.0 nM
CC(=O)N1CCN(CCCCOc2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)CC1 CHEMBL1632468 IC50 7.0 nM
COc1ccc(NS(=O)(=O)c2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)nn1 CHEMBL2392742 IC50 7.0 nM
CCC(C)C(=O)N1CCC(C(=O)NCc2ccc(OC)cc2C(F)(F)F)CC1 CHEMBL4080506 IC50 7.0 nM
COC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1 CHEMBL4205926 IC50 7.0 nM
O=C(Nc1ccc(Oc2ccc(C(=O)O)cc2)cc1)Nc1ccc(OC(F)(F)F)cc1 CHEMBL4203466 IC50 7.0 nM
O=C(Nc1ccc(Cl)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1 CHEMBL4212165 IC50 7.0 nM
CC(C#Cc1cccc(C(=O)NCCC(c2ccccc2)c2ccc(OC(F)(F)F)cc2)c1)N(O)C(N)=O CHEMBL4757630 IC50 7.0 nM
CCOCCn1cc(C(=O)Nc2ccc(-n3nc(-c4cccnc4)cc3C(F)(F)F)cn2)ccc1=O CHEMBL4516982 IC50 7.0 nM
CS(=O)(=O)Nc1ccc(CNC(=O)c2ccc(C(F)(F)F)cc2)c(Cl)c1 CHEMBL5093975 IC50 7.0 nM
Nc1ccc(CNC(=O)c2ccc3c(ccn3Cc3cccc(F)c3)c2)c(C(F)(F)F)c1 CHEMBL5087861 IC50 7.0 nM
CCCCCCCCCCCCNC(=O)NC1CCCCC1 CHEMBL3661355 Ki 7.0 nM
CC(C)(C)OC(=O)N1CCN(CCCCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1 CHEMBL1632470 IC50 7.1 nM
C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](NC(=O)Nc1ccc(C(=O)N4CCC(C(=O)N(CO)CO)CC4)cc1F)(C3)C2 CHEMBL5437028 IC50 7.1 nM
CCC(=O)N1CCC(NC(=O)Nc2ccc(I)cc2)CC1 CHEMBL1258337 IC50 7.2 nM
O=C(NCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2 CHEMBL3263293 IC50 7.2 nM
S=C(NCCCCCCCNC(=S)NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2 CHEMBL4128873 IC50 7.2 nM
CC(=O)N1CCC(NC(=O)NC23CC4C5CC6CC4C(C2)C(C6)C5C3)CC1 CHEMBL4467051 IC50 7.2 nM
O=C(Nc1ccc2c(c1)CCN2Cc1ccc(F)cc1)NC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3 CHEMBL5408127 IC50 7.22 nM
O=C(NCC1CCN(C(=O)c2ccncc2)CC1)NC12CC3CC(CC(C3)C1)C2 CHEMBL215069 IC50 7.3 nM
O=C(Nc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)cc1)c1ccncc1 CHEMBL1271498 IC50 7.3 nM
CC(C)(C)OC(=O)N1CCN(C(=O)c2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1 CHEMBL3222115 IC50 7.3 nM
O=C(NCCCCCCCCNC(=O)NCC12CC3CC(CC(C3)C1)C2)NCC12CC3CC(CC(C3)C1)C2 CHEMBL3263290 IC50 7.3 nM
COc1cccc(OC2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)c1 CHEMBL3114599 IC50 7.4 nM
Cc1cc(C(=O)Nc2ccc(Cl)cc2)ccc1N(CCN1CCSCC1)C(=O)Nc1ccc(Cl)cc1 CHEMBL5202170 IC50 7.4 nM
CCCCCCCC(NC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@H]1O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]1O CHEMBL224266 IC50 7.5 nM
O=C(NC1CC1c1ccccc1)N1CCC(c2nc3ccccc3o2)CC1 CHEMBL552402 IC50 7.5 nM
O=C(NCC1CCN(C(=O)c2ccccn2)CC1)NC12CC3CC(CC(C3)C1)C2 CHEMBL386855 IC50 7.6 nM
O=C(CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)NCC(=O)N[C@H]1O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]1O CHEMBL375113 IC50 7.6 nM
O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccc(F)cc2[N+](=O)[O-])CC1 CHEMBL1933648 IC50 7.7 nM
S=C(NCCCCCCNC(=S)NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2 CHEMBL4128756 IC50 7.7 nM
O=C(O)c1ccc(O[C@H]2CC[C@H](N3C(=O)C(=O)N(c4ccc(OC(F)(F)F)cc4)C3=O)CC2)cc1 CHEMBL4632921 IC50 7.7 nM
CN1CCN(CCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1 CHEMBL1632475 IC50 7.8 nM
CC(C)(C)c1ccc(C(=O)NCc2ccc(NS(=O)(=O)C3CC3)cc2Cl)cc1 CHEMBL5081303 IC50 7.8 nM
Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)c(C)c1 CHEMBL469792 IC50 7.9 nM
O=C(NCCC(c1ccccc1)c1ccccc1)c1ccncc1 CHEMBL571898 IC50 7.9 nM
CON(C)C(=O)C(=O)N(C)c1ccc(CNC(=O)CC23CC4CC(CC(C4)C2)C3)cc1 CHEMBL3103786 IC50 7.9 nM
CNc1nc(NC[C@H](C)c2ccccc2)nc(N[C@H]2CC[C@@H](C(=O)NCc3ccc(C(=O)O)cc3)CC2)n1 CHEMBL4641357 pIC50 7.943 nM
O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC2(CC1)CC(O)c1ncccc1O2 CHEMBL523565 IC50 8.0 nM
O=C1CC2(CCN(C(=O)NC3CCc4ccccc4CC3)CC2)Oc2ccccc21 CHEMBL519149 IC50 8.0 nM
O=C(NC1CCc2ccccc2C1)N1CCC(c2nc(-c3ccccn3)no2)CC1 CHEMBL550242 IC50 8.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)Nc1cccc(OCCCN2CCOCC2)c1 CHEMBL457032 IC50 8.0 nM
O=C(NCCC(c1ccc(F)cc1)c1ccc(F)cc1)c1cccnc1 CHEMBL563216 IC50 8.0 nM
FC(F)(F)c1ccc(Nc2noc3cc(-c4ccccc4C(F)(F)F)ccc23)cc1 CHEMBL583880 IC50 8.0 nM
FC(F)(F)c1ccc(Nc2noc3c(-c4ccc5[nH]ccc5c4)cccc23)cc1 CHEMBL576212 IC50 8.0 nM
CC1(c2ccccc2)CCCN(C(=O)NCc2ccc(-c3ccccc3C(F)(F)F)cc2)C1 CHEMBL1080974 IC50 8.0 nM
O=C(CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1)N1CCOCC1 CHEMBL1078232 IC50 8.0 nM
O=C(O)CCC1(c2ccc(-c3ccccc3)cc2)CCCN(C(=O)Nc2ccc(OC(F)(F)F)cc2)C1 CHEMBL1079061 IC50 8.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(F)c(C(=O)N2CCOCC2)c1 CHEMBL1087468 IC50 8.0 nM
O=C(Nc1ccc(C(=O)Nc2cccnc2)cc1)Nc1ccc(C(F)(F)F)cc1 CHEMBL1087450 IC50 8.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NN1CCC(Oc2ccc(C(=O)O)cc2)CC1 CHEMBL4208326 IC50 8.0 nM
O=C(Nc1ccc(F)c(F)c1F)NC1C2CC3C4CC5CC3C1C(C5)C4C2 CHEMBL4463408 IC50 8.0 nM
O=C(NCc1ccc(NS(=O)(=O)C2CC2)cc1C(F)(F)F)c1ccc2c(ccn2Cc2cccc(F)c2)c1 CHEMBL5084336 IC50 8.0 nM
O=C(NCCC(c1ccccc1)c1ccccc1)c1ccc(=O)[nH]c1 CHEMBL567503 IC50 8.1 nM
O=C(NC1CCCC(C(=O)N2CCOCC2)C1)NC12CC3CC(CC(C3)C1)C2 CHEMBL2032040 IC50 8.2 nM
CCOP(=O)(OCC)C(Nc1ccc(CCNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C CHEMBL3629066 IC50 8.2 nM
S=C(NCCc1ccccc1)NC1C2CC3CC(C2)CC1C3 CHEMBL4126432 IC50 8.2 nM
CCC(=O)N1CCC(NC(=O)Nc2ccc(CC)cc2)CC1 CHEMBL1257757 IC50 8.3 nM
Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc4ccccc4c3)CC2)c(C)c1 CHEMBL2313180 IC50 8.3 nM
Cc1ccc(NC(=O)N(CCN2CCOCC2)c2ccc3nc(N)sc3c2)cc1 CHEMBL4742920 IC50 8.3 nM
CCC(CC12CC3CC(CC(C3)C1)C2)N1C(=O)C(=O)N(CCCCN2C(=O)C(=O)N(C(CC)CC34CC5CC(CC(C5)C3)C4)C2=O)C1=O CHEMBL4645106 IC50 8.4 nM
Cc1cc(C(=O)Nc2ccc(Cl)cc2)ccc1N(CCN1CCS(=O)(=O)CC1)C(=O)Nc1ccc(Cl)cc1 CHEMBL5206926 IC50 8.4 nM
COC(=O)c1ccc(NC(=O)C2CCN(S(=O)(=O)c3ccc(C)cc3C)CC2)cc1 CHEMBL2313194 IC50 8.5 nM
O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)N[C@H]1CC[C@H](Oc2cccc(C(=O)O)c2)CC1 CHEMBL2397144 IC50 8.6 nM
O=C(NC12CC3CC(CC1C3)C2)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1 CHEMBL4465856 IC50 8.6 nM
CCC(=O)N1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL215874 IC50 8.7 nM
O=C(Nc1cccc(C(F)(F)F)c1)NC1CCCCC1 CHEMBL1610486 IC50 8.7 nM
Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccccc3Cl)CC2)c(C)c1 CHEMBL2313168 IC50 8.7 nM
Cc1ccc2sc(-c3ccc(NC(=O)C4CCN(S(=O)(=O)c5ccccc5Cl)CC4)cc3)nc2c1 CHEMBL5092295 IC50 8.7 nM
O=C(NCCC(c1ccccc1)c1ccccc1)c1ccc([18F])nc1 CHEMBL5191424 IC50 8.7 nM
O=C(Nc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)nn1)c1ccccc1 CHEMBL1271659 IC50 8.8 nM
Cc1cc(C(=O)Nc2ccc(Cl)cc2)ccc1N(CCN1CC[S+]([O-])CC1)C(=O)Nc1ccc(Cl)cc1 CHEMBL5196556 IC50 8.8 nM
Cc1cccc(OC2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)c1 CHEMBL3114593 IC50 8.9 nM
CC(C)(C)c1ccc(C(=O)NCc2ccc(NC(=O)C(F)(F)F)cc2Cl)cc1 CHEMBL4087681 IC50 8.9 nM
COC(=O)CCC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 CHEMBL215827 IC50 9.0 nM
O=C(NCCCCCOCCCN1CCOCC1)NC12CC3CC(CC(C3)C1)C2 CHEMBL245151 IC50 9.0 nM
O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3ccccn3)no2)CC1 CHEMBL552382 IC50 9.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)Nc1cccc(C(=O)N2CCOCC2)c1 CHEMBL1096113 IC50 9.0 nM
O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Oc2ccncc2)CC1 CHEMBL1085746 IC50 9.0 nM
CCOCCOCC(OC(=O)C1CCCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)C1)c1ccccc1 CHEMBL2070334 IC50 9.0 nM
CC(=O)N1CCN(C(=O)c2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)CC1 CHEMBL3222117 IC50 9.0 nM
O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)N[C@H]1CC[C@H](Oc2ccc(C(F)(F)F)cn2)CC1 CHEMBL3677981 IC50 9.0 nM
O=C(NC12CC3CC(CC(C3)O1)C2)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1 CHEMBL4779073 IC50 9.0 nM
CNc1nc(NC2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)nc(N2CCN(C)CC2)n1 CHEMBL4850549 IC50 9.0 nM
COC(C)(C)c1ccc(C(=O)NCc2ccc(NS(C)(=O)=O)cc2Cl)cc1 CHEMBL5094442 IC50 9.0 nM
CC(=O)N1CCC(NC(=O)NC23CC4CC(F)(CC(C2)c2ccccc24)C3)CC1 CHEMBL5169759 IC50 9.0 nM
CC[C@H](C)C(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)c(OC(F)(F)F)c2)CC1 CHEMBL4747426 Ki 9.07 nM
O=C(CC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1 CHEMBL243302 IC50 9.1 nM
Nc1ccc(C(=O)NCCC(c2ccccc2)c2ccccc2)cn1 CHEMBL568773 IC50 9.1 nM
O=C(Nc1ccc(/C=C/c2nc3ccccc3s2)cc1)Nc1ccc(Cl)c(Cl)c1 CHEMBL4578414 IC50 9.1 nM
O=C(Nc1ccc(-c2nccs2)cc1)C1CCN(S(=O)(=O)c2ccccc2Cl)CC1 CHEMBL5083307 IC50 9.2 nM
CC(=O)c1ccc(NC(=O)c2ccc(N(CCN3CCOCC3)C(=O)Nc3ccc(Cl)cc3)c(C)c2)cc1 CHEMBL5190767 IC50 9.5 nM
COc1cc(C(=O)N2CCN(CCCCOc3cccc(NC(=O)NC45CC6CC(CC(C6)C4)C5)c3)CC2)cc(OC)c1OC CHEMBL1632485 IC50 9.6 nM
Cc1c(C)c(C)c(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)c(C)c1C CHEMBL1933661 IC50 9.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)Nc1ccc(OC(F)(F)F)cc1 CHEMBL2031937 IC50 9.6 nM
CC12CC3CC(C)(C1)CC(NC(=O)NC1C4CC5CC(C4)CC1C5)(C3)C2 CHEMBL4646874 IC50 9.6 nM
O=C(Nc1ccc(-c2nc3ccccc3s2)cc1)C1CCN(S(=O)(=O)c2ccccc2Cl)CC1 CHEMBL5089361 IC50 9.6 nM
O=C(Nc1ccc(-c2nc(-c3ccc(Cl)cc3)cs2)cc1)C1CCN(S(=O)(=O)c2ccccc2Cl)CC1 CHEMBL5093204 IC50 9.6 nM
S=C(NCCCCCCCCNC(=S)NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2 CHEMBL4130236 IC50 9.8 nM
O=C(Nc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)nc1)c1ccccc1 CHEMBL1271658 IC50 9.9 nM
CC[C@H](C)C(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)c(C(F)(F)F)c2)CC1 CHEMBL4760255 Ki 9.91 nM