COCCN(C)[C@H]1CC[C@H](Nc2ncc3cc(-c4ccc(NS(=O)(=O)Cc5ccc(F)cc5)c(F)c4)c(=O)n(C(C)C)c3n2)CC1 CHEMBL4757194 IC50 0.05 nM
CC(C)n1c(=O)c(-c2c(F)cc(NS(=O)(=O)Cc3ccc(F)cc3)cc2F)cc2cnc(N[C@H]3CC[C@H](N(C)C)CC3)nc21 CHEMBL4777304 IC50 0.08 nM
Cc1ccc(CS(=O)(=O)Nc2ccc(-c3nc4cnc(N[C@@H]5CNC[C@@H](F)C5)nc4n(C(C)C)c3=O)cc2F)c(C#N)c1 CHEMBL4789787 IC50 0.09 nM
CC(C)n1c(=O)c(-c2ccc(NS(=O)(=O)Cc3ccc(C#N)cc3)c(F)c2)nc2cnc(N[C@@H]3CNC[C@@H](F)C3)nc21 CHEMBL4798215 IC50 0.1 nM
CC(C)n1c(=O)c(-c2cc(F)c(NS(=O)(=O)CC3(C(F)(F)F)CC3)c(F)c2)nc2cnc(N[C@H]3CC[C@H](N(C)C)CC3)nc21 CHEMBL4748828 IC50 0.1 nM
COc1cccc(CS(=O)(=O)Nc2c(F)cc(-c3cc4cnc(N[C@@H]5CNC[C@@H](F)C5)nc4n(C(C)C)c3=O)c(F)c2F)c1 CHEMBL4790916 IC50 0.11 nM
CC(C)NC(=O)c1cccc(-c2ccc3c(C=O)c(O)ccc3c2)c1 CHEMBL3665053 IC50 3.0 nM
Cc1cc(NS(=O)(=O)c2ccccc2Cl)c2ccccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CC[C@H](N)CC2)n1 CHEMBL3356007 IC50 4.2 nM
CN1CCN(C(=O)c2ccc(-c3ccc4c(C=O)c(O)ccc4c3)s2)CC1 CHEMBL3665060 IC50 5.0 nM
CN1CCN(C(=O)c2ccc(-c3ccc4c(C=O)c(O)ccc4c3)o2)CC1 CHEMBL3917195 IC50 5.0 nM
Cc1cc(Nc2nc3ccccc3[nH]2)c2ccccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CCCNC2)n1 CHEMBL3356002 IC50 5.1 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 5.7 nM
COc1cc(-c2cccc(C(=O)NCc3ccccc3)c2)cc(C=O)c1O CHEMBL3665025 IC50 6.0 nM
Cc1cc(Nc2nc3ccccc3[nH]2)c2ccccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CC[C@H](N)CC2)n1 CHEMBL3356001 IC50 6.4 nM
c1cnc(Oc2ccc(Nc3nc4ccccc4[nH]3)c3ccccc23)c(-c2ccnc(N[C@H]3CCCNC3)n2)c1 CHEMBL3355998 IC50 9.7 nM
N[C@H]1CC[C@H](Nc2nccc(-c3cccnc3Oc3ccc(Nc4nc5ccccc5[nH]4)c4ccccc34)n2)CC1 CHEMBL3355999 IC50 11.0 nM
Cc1cc(NS(=O)(=O)c2ccccc2C#N)c2ccccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CC[C@H](N)CC2)n1 CHEMBL3356006 IC50 12.0 nM
Cc1ccc2c(NS(=O)(=O)c3ccccc3Cl)cccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CCCNC2)n1 CHEMBL3356009 IC50 13.0 nM
Cc1cc(Nc2nc3ccccc3o2)c2ccccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CC[C@H](N)CC2)n1 CHEMBL3356003 IC50 14.0 nM
Cc1cc(Nc2nc3ccccc3[nH]2)c2ccccc2c1Oc1ncccc1-c1ccnc(NCCN(C)C)n1 CHEMBL3355993 IC50 14.0 nM
COc1cc(-c2cccs2)cc(/C=N\CCO)c1O CHEMBL3665083 IC50 15.0 nM
COc1cc(-c2cccc(C(=O)NC3CCCCC3)c2)cc(C=O)c1O CHEMBL3665022 IC50 19.0 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 19.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 21.0 nM
COC(=O)c1ccc(-c2cc(C=O)c(O)c([N+](=O)[O-])c2)cc1 CHEMBL3660455 IC50 21.0 nM
Cc1ccc2c(NS(=O)(=O)c3ccccc3Cl)cccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CC[C@H](N)CC2)n1 CHEMBL3356008 IC50 22.0 nM
COc1cc(-c2cccs2)cc(C=O)c1O CHEMBL3660320 IC50 22.0 nM
N[C@H]1CC[C@H](Nc2ncnc3c(C(=O)Nc4c(Cl)ccc(NS(=O)(=O)c5ccccc5Cl)c4F)csc23)CC1 CHEMBL4781285 IC50 22.0 nM
O=Cc1c(O)ccc2cc(-c3cccnc3)ccc12 CHEMBL3665027 IC50 23.0 nM
COc1ccc(C/N=C/c2cc(-c3cccs3)cc(OC)c2O)cc1 CHEMBL3665082 IC50 23.0 nM
N[C@H]1CC[C@H](Nc2ncnc3c(C(=O)Nc4c(Cl)ccc(NS(=O)(=O)c5cc(F)ccc5F)c4F)csc23)CC1 CHEMBL4786638 IC50 24.0 nM
NC(=O)c1cccc(-c2ccc3c(C=O)c(O)ccc3c2)c1 CHEMBL3665043 IC50 26.0 nM
O=C(CN1CCOCC1)N[C@H]1CC[C@H](Nc2cc(Cl)nn3c(-c4ccc5[nH]ncc5c4)cnc23)CC1 CHEMBL4565193 IC50 27.0 nM
CN1CCCC(Nc2nccc(-c3cccnc3Oc3ccc(Nc4nc5ccccc5[nH]4)c4ccccc34)n2)C1 CHEMBL3355996 IC50 29.0 nM
COc1cc(Br)c(Br)c(C=O)c1O CHEMBL3660308 IC50 30.0 nM
O=Cc1cc(-c2cccs2)cc([N+](=O)[O-])c1O CHEMBL3660309 IC50 30.0 nM
N[C@H]1CC[C@H](Nc2ncnc3c(C(=O)Nc4c(Cl)ccc(NS(=O)(=O)Cc5ccccc5)c4F)csc23)CC1 CHEMBL4760343 IC50 30.0 nM
N[C@H]1CC[C@H](Nc2nccc(-c3cccnc3Oc3ccc(NS(=O)(=O)c4ccccc4Cl)c4ccccc34)n2)CC1 CHEMBL3356010 IC50 31.0 nM
Cc1cc(C(=O)Nc2c(Cl)ccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)c2ncnc(N)c2c1 CHEMBL4757144 IC50 31.0 nM
NC(=O)c1cccc(-c2cc(C=O)c(O)c([N+](=O)[O-])c2)c1 CHEMBL3660456 IC50 32.0 nM
CC(=O)N[C@H]1CC[C@H](Nc2cc(Cl)nn3c(-c4ccc5[nH]ncc5c4)cnc23)CC1 CHEMBL4576457 IC50 33.0 nM
Nc1ncnc2c(C(=O)Nc3c(Cl)ccc(NS(=O)(=O)c4cc(F)ccc4F)c3F)cc(-c3ccncc3)cc12 CHEMBL4758021 IC50 33.0 nM
O=Cc1cc(-c2cccs2)cc(F)c1O CHEMBL3660310 IC50 34.0 nM
COc1cc(-c2cccs2)cc(/C=N/C2CC2)c1O CHEMBL3665081 IC50 34.0 nM
CN(C)C(=O)c1ccc(-c2ccc3c(C=O)c(O)ccc3c2)cc1 CHEMBL3665031 IC50 36.0 nM
COc1cc(-c2cncnc2)cc(C=O)c1O CHEMBL3660401 IC50 39.0 nM
COc1ccc(CNC(=O)c2cccc(-c3cc(F)c(O)c(C=O)c3)c2)cc1 CHEMBL3665021 IC50 40.0 nM
Cc1nn(C)cc1-c1cc(C(=O)Nc2c(Cl)ccc(NS(=O)(=O)c3ccccc3F)c2F)c2ncnc(N)c2c1 CHEMBL4752754 IC50 40.0 nM
N[C@H]1CC[C@@H](Nc2nccc(-c3cccnc3Oc3ccc(Nc4nc5ccccc5[nH]4)c4ccccc34)n2)CC1 CHEMBL3356000 IC50 43.0 nM
Cc1cc(NS(=O)(=O)c2ccccc2)c2ccccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CC[C@H](N)CC2)n1 CHEMBL3356004 IC50 45.0 nM
O=Cc1c(O)cnc2ccccc12 CHEMBL3665063 IC50 45.0 nM
CC(=O)c1ccc(-c2cc(F)c(O)c(C=O)c2)s1 CHEMBL3660393 IC50 46.0 nM
NC(=O)c1cccc(-c2cc(F)c(O)c(C=O)c2)c1 CHEMBL3660434 IC50 46.0 nM
N=C(N)N1CCc2c(c(=O)oc3c(C=O)c(O)ccc23)C1 CHEMBL3265274 IC50 47.0 nM
CC(C)NC(=O)c1cccc(-c2ccc3c(C=O)c(O)ccc3c2)n1 CHEMBL3665054 IC50 47.0 nM
NC(=O)c1ccc(Br)c(C=O)c1O CHEMBL3665097 IC50 47.0 nM
Nc1ncnc2c(C(=O)Nc3c(Cl)ccc(NS(=O)(=O)c4cc(F)ccc4F)c3F)cc(-c3cccnc3)cc12 CHEMBL4755886 IC50 47.0 nM
O=Cc1c(O)ccc2cc(-c3cccc(C(=O)NCCN4CCOCC4)n3)ccc12 CHEMBL3665057 IC50 48.0 nM
Cc1nn(C)cc1-c1cc(C(=O)Nc2c(Cl)ccc(NS(=O)(=O)c3ccccc3Cl)c2F)c2ncnc(N)c2c1 CHEMBL4758147 IC50 48.0 nM
Cn1cc(-c2cc(C(=O)Nc3c(Cl)ccc(NS(=O)(=O)c4cc(F)ccc4F)c3F)c3ncnc(N)c3c2)cn1 CHEMBL4747176 IC50 50.0 nM
c1cnc(Oc2ccc(Nc3nc4ccccc4[nH]3)c3ccccc23)c(-c2ccnc(N[C@@H]3CCCNC3)n2)c1 CHEMBL3355997 IC50 51.0 nM
COc1cc(-c2ccco2)cc(C=O)c1O CHEMBL3660419 IC50 51.0 nM
Cn1nccc1-c1cc(C(=O)Nc2c(Cl)ccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)c2ncnc(N)c2c1 CHEMBL4759829 IC50 53.0 nM
COc1ccccc1S(=O)(=O)Nc1cc(C)c(Oc2ncccc2-c2ccnc(N[C@H]3CC[C@H](N)CC3)n2)c2ccccc12 CHEMBL3356005 IC50 54.0 nM
NC(=O)c1ccc(-c2cc(C=O)c(O)c([N+](=O)[O-])c2)cc1 CHEMBL3660457 IC50 54.0 nM
Nc1ncnc2c(C(=O)Nc3c(Cl)ccc(NS(=O)(=O)c4cc(F)ccc4F)c3F)cccc12 CHEMBL4753548 IC50 56.0 nM
O=Cc1cc(-c2cccc(C(=O)NCCN3CCCCC3)c2)ccc1O CHEMBL3665020 IC50 66.0 nM
O=Cc1c(O)ccc2cc(-c3cncnc3)ccc12 CHEMBL3665028 IC50 66.0 nM
O=Cc1c(O)ccc2cc(-c3ccc(C(=O)N4CCOCC4)cc3)ccc12 CHEMBL3665056 IC50 67.0 nM
Nc1ncnc2c(C(=O)Nc3c(Cl)ccc(NS(=O)(=O)c4cc(F)ccc4F)c3F)csc12 CHEMBL4749470 IC50 67.0 nM
O=Cc1cc(-c2cncnc2)cc(F)c1O CHEMBL3660311 IC50 70.0 nM
CN(C)CCNc1nccc(-c2cccnc2Oc2ccc(Nc3nc4ccccc4[nH]3)c3ccccc23)n1 CHEMBL3355992 IC50 71.0 nM
N[C@H]1CC[C@H](Nc2cc(Cl)nn3c(-c4ccc5[nH]ncc5c4)cnc23)CC1 CHEMBL4444939 IC50 72.0 nM
COc1ccc(-c2cc(C=O)c(O)c(OC)c2)cn1 CHEMBL3660387 IC50 74.0 nM
O=Cc1cc(-c2ccsc2)cc(F)c1O CHEMBL3660414 IC50 74.0 nM
O=Cc1c(O)ccc2cc(-c3cccc(C(=O)N4CCOCC4)c3)ccc12 CHEMBL3665029 IC50 74.0 nM
Nc1ncnc2c(C(=O)Nc3c(Cl)ccc(NS(=O)(=O)c4cc(F)ccc4F)c3F)cc(-c3cn[nH]c3)cc12 CHEMBL4787548 IC50 76.0 nM
O=Cc1c(O)ccc2cc(-c3cccc(C(=O)O)c3)ccc12 CHEMBL3665030 IC50 79.0 nM
COc1ccc(Br)c(C=O)c1O CHEMBL93215 IC50 80.0 nM
O=Cc1cc(-c2cccs2)ccc1O CHEMBL3660312 IC50 80.0 nM
CN1CCC(CNc2cc(Cl)nn3c(-c4cc5nc(Nc6ccccc6)[nH]c5cc4F)cnc23)CC1 CHEMBL4588737 IC50 80.0 nM
O=Cc1cc(-c2ccoc2)cc([N+](=O)[O-])c1O CHEMBL3660421 IC50 81.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 81.0 nM
COc1cc(-c2cc3ccccc3o2)cc(C=O)c1O CHEMBL3660389 IC50 82.0 nM
COc1cc(-c2ccc(C(N)=O)cc2)cc(C=O)c1O CHEMBL3660428 IC50 82.0 nM
Cc1nn(C)cc1-c1cc(C(=O)Nc2c(Cl)ccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)c2ncnc(N)c2c1 CHEMBL4754759 IC50 82.0 nM
O=Cc1cc(-c2cccc(C(=O)NCCN3CCOCC3)c2)ccc1O CHEMBL3665017 IC50 84.0 nM
NC(=O)c1ccc(-c2cc(F)c(O)c(C=O)c2)cc1 CHEMBL3660466 IC50 85.0 nM
O=Cc1cc(-c2ccoc2)cc(F)c1O CHEMBL3660423 IC50 88.0 nM
Cn1ccc(-c2cc(C(=O)Nc3c(Cl)ccc(NS(=O)(=O)c4cc(F)ccc4F)c3F)c3ncnc(N)c3c2)n1 CHEMBL4743690 IC50 89.0 nM
CN1CCC(CNc2cc(Cl)nn3c(-c4ccc5[nH]c(Nc6ccccc6)nc5c4)cnc23)CC1 CHEMBL4453631 IC50 90.0 nM
CCCNC(=O)c1cccc(-c2cc(C=O)c(O)c([N+](=O)[O-])c2)c1 CHEMBL3665024 IC50 94.0 nM
COc1cc(-c2ccc(C(C)=O)s2)cc(C=O)c1O CHEMBL3660381 IC50 97.0 nM
COc1cc(-c2cncc3ccccc23)cc(C=O)c1O CHEMBL3660386 IC50 100.0 nM
CCCNC(=O)c1cccc(-c2ccc(O)c(C=O)c2)c1 CHEMBL3660478 IC50 100.0 nM
CN1CCC(CNc2cc(Cl)nn3c(-c4cc(F)c5[nH]c(Nc6ccccc6)nc5c4)cnc23)CC1 CHEMBL4516160 IC50 100.0 nM
O=Cc1cc(-c2ccc(C(=O)O)cc2)cc([N+](=O)[O-])c1O CHEMBL3660459 IC50 101.0 nM
COc1cc(-c2cccc(C(=O)O)c2)cc(C=O)c1O CHEMBL3660316 IC50 102.0 nM
COc1cc(-c2ccncc2)cc(C=O)c1O CHEMBL3660336 IC50 104.0 nM
O=Cc1cc(-c2cncc3ccccc23)cc(F)c1O CHEMBL3660394 IC50 104.0 nM
O=Cc1cc(-c2cccc(C(=O)NCc3ccccc3)c2)ccc1O CHEMBL3660479 IC50 106.0 nM
COc1cc(-c2ccccn2)cc(C=O)c1O CHEMBL3665099 IC50 108.0 nM
COc1cc(-c2ccc3c(c2)OCCCO3)cc(C=O)c1O CHEMBL3660313 IC50 110.0 nM
COc1cc(Br)cc(/C=N/C2CC2)c1O CHEMBL3665079 IC50 110.0 nM
CN(c1cc(Cl)nn2c(-c3ccc4[nH]ncc4c3)cnc12)[C@H]1CC[C@H](N2CCOCC2)CC1 CHEMBL4534769 IC50 110.0 nM
C=CCOC(=O)N1CCc2c(c(=O)oc3c(C=O)c(O)ccc23)C1 CHEMBL3265261 IC50 111.0 nM
O=Cc1c(O)ccc2c3c(c(=O)oc12)CN(Cc1ccccc1)CC3 CHEMBL3265271 IC50 113.0 nM
COc1cc(-c2ccoc2)cc(C=O)c1O CHEMBL3660418 IC50 114.0 nM
C=CCOC(=O)NCCCCc1cc(=O)oc2c(C=O)c(O)ccc12 CHEMBL3265285 IC50 118.0 nM
C=CCOC(=O)N1CCCc2c(c(=O)oc3c(C=O)c(O)ccc23)C1 CHEMBL3265286 IC50 118.0 nM
COc1cc(C)cc(C=O)c1O CHEMBL3660314 IC50 120.0 nM
Cc1cc(C=O)c(O)c(C=O)c1 CHEMBL3904097 IC50 120.0 nM
CN(C)C(=O)c1cccc(-c2ccc3c(C=O)c(O)ccc3c2)c1 CHEMBL3665044 IC50 125.0 nM
O=Cc1c(O)ccc2cc(-c3cccc(C(=O)O)n3)ccc12 CHEMBL3665049 IC50 125.0 nM
COc1ncc(-c2cc(C=O)c(O)c(OC)c2)s1 CHEMBL3665102 IC50 128.0 nM
CN1CCC(Nc2cc(Cl)nn3c(-c4ccc5[nH]ncc5c4)cnc23)CC1 CHEMBL4530582 IC50 130.0 nM
CN1CCC(Nc2cc(Cl)nn3c(-c4ccc5[nH]c(Nc6ccccc6)nc5c4)cnc23)CC1 CHEMBL4450996 IC50 130.0 nM
NC(=O)c1ccc(-c2ccc(O)c(C=O)c2)cc1 CHEMBL3660448 IC50 131.0 nM
O=Cc1cc(-c2cccc(C(=O)O)c2)cc([N+](=O)[O-])c1O CHEMBL3660454 IC50 132.0 nM
CN1CCc2c(c(=O)oc3c(C=O)c(O)ccc23)C1 CHEMBL3265270 Kd 138.0 nM
O=Cc1cc(-c2cccnc2)ccc1O CHEMBL3660426 IC50 141.0 nM
COc1cc(-c2ccc3c(c2)CCO3)cc(C=O)c1O CHEMBL3660330 IC50 143.0 nM
COc1cc(-c2cnc3ccc(NC(C)C)nn23)ccc1C(N)=O CHEMBL4554474 EC50 143.0 nM
O=Cc1cc(-c2ccncc2)ccc1O CHEMBL3660376 IC50 147.0 nM
CN(C)C(=O)c1cccc(-c2ccc(O)c(C=O)c2)c1 CHEMBL3660453 IC50 147.0 nM
COc1cc(-c2cccnc2)cc(C=O)c1O CHEMBL3660378 IC50 149.0 nM
C=CCOC(=O)N1CCCCc2c(c(=O)oc3c(C=O)c(O)ccc23)C1 CHEMBL3265287 IC50 150.0 nM
O=Cc1c(O)ccc2cc(-c3ccc(C(=O)O)s3)ccc12 CHEMBL3665061 IC50 151.0 nM
COc1cc(Br)cc(/C=N/CCO)c1O CHEMBL3665088 IC50 154.0 nM
O=Cc1cc(C#Cc2ccccn2)ccc1O CHEMBL3920586 IC50 155.0 nM
CN1CCN(C(=O)c2cccc(-c3ccc4c(C=O)c(O)ccc4c3)c2)CC1 CHEMBL3665051 IC50 157.0 nM
O=Cc1c(O)ccc2cc(-c3ccc(C(=O)N4CCOCC4)s3)ccc12 CHEMBL3665059 IC50 157.0 nM
COc1cc(-c2cccs2)cc(/C=N/c2nn[nH]n2)c1O CHEMBL3665087 IC50 157.0 nM
O=Cc1c(O)ccc2cc(-c3ccc(C(=O)N4CCOCC4)o3)ccc12 CHEMBL3895174 IC50 157.0 nM
COc1cc(-c2cccs2)cc(/C=N/C2N=NN=N2)c1O CHEMBL3934961 IC50 157.0 nM
O=Cc1cc(-c2cccc(C(=O)NC3CCCCC3)c2)ccc1O CHEMBL3660477 IC50 158.0 nM
CN1CCC(CNc2cc(Cl)nn3c(-c4ccc5[nH]ncc5c4)cnc23)CC1 CHEMBL4568715 IC50 160.0 nM
CN1CCC(CNc2cc(Cl)nn3c(-c4ccc5[nH]c(Nc6ccccc6)nc5c4F)cnc23)CC1 CHEMBL4538288 IC50 160.0 nM
COc1cc(-c2ccc(C(=O)N(C)C)cc2)cc(C=O)c1O CHEMBL3660430 IC50 162.0 nM
O=Cc1cc(-c2cccnc2)cc(F)c1O CHEMBL3660377 IC50 163.0 nM
O=Cc1cc(-c2cncc3ccccc23)cc(C(F)(F)F)c1O CHEMBL3660396 IC50 164.0 nM
COc1ccc(-c2cc(F)c(O)c(C=O)c2)cn1 CHEMBL3660380 IC50 168.0 nM
OCCNc1nccc(-c2cccnc2Oc2ccc(Nc3nc4ccccc4[nH]3)c3ccccc23)n1 CHEMBL3355995 IC50 170.0 nM
COc1cc([N+](=O)[O-])cc(C=O)c1O CHEMBL3660315 IC50 170.0 nM
O=Cc1cc(-c2cncnc2)ccc1O CHEMBL3639592 IC50 170.0 nM
O=Cc1c(O)ccc2ncccc12 CHEMBL3665062 IC50 170.0 nM
O=Cc1cc(-c2ccc(C(=O)O)cc2)ccc1O CHEMBL3660472 IC50 172.0 nM
COc1cc(-c2cccc(C(N)=O)c2)cc(C=O)c1O CHEMBL3660432 IC50 173.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 180.0 nM
C=CCOC(=O)NCCCc1cc(=O)oc2c(C=O)c(O)ccc12 CHEMBL3265284 IC50 181.0 nM
O=Cc1cc(-c2ccco2)cc(F)c1O CHEMBL3660391 IC50 190.0 nM
Clc1cc(NC2CCOCC2)c2ncc(-c3ccc4[nH]ncc4c3)n2n1 CHEMBL4468785 IC50 190.0 nM
COC(=O)c1cccc(-c2cc(C=O)c(O)c(OC)c2)c1 CHEMBL3660443 IC50 192.0 nM
NC(=O)c1cccc(-c2ccc(O)c(C=O)c2)c1 CHEMBL3660452 IC50 197.0 nM
COc1cc(-c2ccsc2)cc(C=O)c1O CHEMBL3660408 IC50 199.0 nM
Clc1cc(NC2CCOCC2)c2ncc(-c3ccc4[nH]c(Nc5ccccc5)nc4c3)n2n1 CHEMBL4515949 IC50 200.0 nM
Nc1ncnc2c(C(=O)Nc3c(Cl)ccc(NS(=O)(=O)N4CCCC4)c3F)cccc12 CHEMBL4780489 IC50 200.0 nM
Cc1cc(=O)oc2c(C=O)c(O)ccc12 CHEMBL272357 IC50 206.0 nM
COC(=O)c1ccc(-c2cc(F)c(O)c(C=O)c2)cc1 CHEMBL3660449 IC50 213.0 nM
O=Cc1cc(-c2ccc(C(=O)O)cc2)cc(F)c1O CHEMBL3660465 IC50 214.0 nM
COc1ccc(C/N=C/c2cc(Br)cc(OC)c2O)cc1 CHEMBL3665078 IC50 221.0 nM
O=Cc1cc(-c2ccc(C(=O)N3CCOCC3)cc2)cc(F)c1O CHEMBL3665100 IC50 221.0 nM
O=Cc1cc(-c2ccco2)cc([N+](=O)[O-])c1O CHEMBL3660420 IC50 223.0 nM
O=Cc1cc(-c2ccco2)ccc1O CHEMBL3660463 IC50 223.0 nM
COc1cc(-c2ccc(C(=O)O)s2)cc(C=O)c1O CHEMBL3660447 IC50 230.0 nM
NC(=O)c1cccc(-c2cc(C=O)c(O)c(C(F)(F)F)c2)c1 CHEMBL3660435 IC50 235.0 nM
Cn1cc(-c2cc(F)c(O)c(C=O)c2)cn1 CHEMBL3660398 IC50 236.0 nM
COc1cc(Br)cc(C=O)c1O CHEMBL3660317 IC50 240.0 nM
COCc1ccc(-c2cc(C=O)c(O)c(OC)c2)cc1 CHEMBL3660318 IC50 240.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4c(F)cccc4F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4462318 Kd(free) 243.0 nM
COc1cc(-c2ccc3c(c2)OCO3)cc(C=O)c1O CHEMBL3660319 IC50 250.0 nM
CC(C)NC(=O)c1cccc(-c2cc(F)c(O)c(C=O)c2)c1 CHEMBL3660480 IC50 253.0 nM
C=C(C)CN1CCc2c(c(=O)oc3c(C=O)c(O)ccc23)C1 CHEMBL3265273 IC50 255.0 nM
COc1cc(Cl)cc(C=O)c1O CHEMBL3660321 IC50 280.0 nM
CC(C)c1nc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)c3ccccc23)c2c(N)nccn12 CHEMBL4471573 IC50 290.0 nM
O=Cc1c(O)ccc2c3c(c(=O)oc12)CNCC3 CHEMBL4524928 Kd 295.0 nM
C=CCOC(=O)NCCc1cc(=O)oc2c(C=O)c(O)ccc12 CHEMBL3265283 IC50 296.0 nM
COc1cc(-c2cnn(C)c2)cc(C=O)c1O CHEMBL3660322 IC50 300.0 nM
O=Cc1c(O)ccc2c3c(c(=O)oc12)CN(Cc1ccc(F)cc1)CC3 CHEMBL3265272 IC50 303.0 nM
COc1cc(C#Cc2cccnc2)cc(C=O)c1O CHEMBL3665105 IC50 303.0 nM
Clc1cc(NCC2CC2)c2ncc(-c3ccc4[nH]ncc4c3)n2n1 CHEMBL4525939 IC50 303.0 nM
O=Cc1cc(-c2cccc3ncccc23)cc(F)c1O CHEMBL3660384 IC50 305.0 nM
COc1cc(-c2cn[nH]c2)cc(C=O)c1O CHEMBL3660397 IC50 310.0 nM
CC(=O)N1CCc2c(c(=O)oc3c(C=O)c(O)ccc23)C1 CHEMBL3265269 IC50 312.0 nM
O=Cc1cc(-c2cncnc2)cc([N+](=O)[O-])c1O CHEMBL3660402 IC50 331.0 nM
O=Cc1cc(-c2cccc3ncccc23)cc([N+](=O)[O-])c1O CHEMBL3660385 IC50 333.0 nM
COc1ccc(-c2cc(C=O)c(O)c([N+](=O)[O-])c2)cn1 CHEMBL3660382 IC50 346.0 nM
O=Cc1cc(-c2ccc(C(=O)N3CCOCC3)cc2)cc(C(F)(F)F)c1O CHEMBL3660439 IC50 348.0 nM
COc1cc(-c2ccc(O)cc2)cc(C=O)c1O CHEMBL3660323 IC50 350.0 nM
COc1ccc(-c2cccs2)c(C=O)c1O CHEMBL3660404 IC50 351.0 nM
COC(=O)c1ccc(-c2ccc(O)c(C=O)c2)cc1 CHEMBL3660461 IC50 351.0 nM
COc1cc(-c2ccc(N3CCOCC3)nc2)cc(C=O)c1O CHEMBL3660464 IC50 367.0 nM
O=Cc1cc(-c2cccc(C(=O)O)c2)ccc1O CHEMBL3660460 IC50 371.0 nM
COc1cc(-c2ccc(S(C)(=O)=O)cc2)cc(C=O)c1O CHEMBL3660433 IC50 379.0 nM
COc1ccc(-c2cc(C=O)c(O)c(OC)c2)cc1OC CHEMBL3660324 IC50 380.0 nM
COc1cc(-c2cccc(OC)c2F)cc(C=O)c1O CHEMBL3660325 IC50 380.0 nM
O=Cc1cc(-c2ccc3c(c2)CCO3)cc(F)c1O CHEMBL3660413 IC50 381.0 nM
COc1cc(-c2ccc(C(=O)N3CCN(C)CC3)s2)cc(C=O)c1O CHEMBL3665018 IC50 389.0 nM
CN1CCN(C(=O)c2cccc(-c3ccc4c(C=O)c(O)ccc4c3)n2)CC1 CHEMBL3665058 IC50 389.0 nM
COc1cc(-c2ccc(CO)cc2)cc(C=O)c1O CHEMBL3660326 IC50 390.0 nM
CN1CCN(C(=O)c2cccc(-c3cc(F)c(O)c(C=O)c3)c2)CC1 CHEMBL3665019 IC50 393.0 nM
COc1cc(-c2cccc(C(=O)N3CCN(C)CC3)c2)cc(C=O)c1O CHEMBL3665023 IC50 396.0 nM
O=Cc1cc(-c2cccc(C(=O)N3CCCCC3)c2)ccc1O CHEMBL3660471 IC50 398.0 nM
O=Cc1cc(Cl)cc(C=O)c1O CHEMBL3660327 IC50 400.0 nM
COc1cc(-c2ccccc2F)cc(C=O)c1O CHEMBL3660328 IC50 400.0 nM
COc1cccc(-c2cc(C=O)c(O)c(OC)c2)c1 CHEMBL3660329 IC50 400.0 nM
O=Cc1cc(-c2ccsc2)cc([N+](=O)[O-])c1O CHEMBL3660405 IC50 401.0 nM
CN(C)C(=O)c1ccc(-c2cc(C=O)c(O)c([N+](=O)[O-])c2)cc1 CHEMBL3660438 IC50 410.0 nM
COc1cc(-c2cccc(C(=O)N(C)C)c2)cc(C=O)c1O CHEMBL3660429 IC50 413.0 nM
O=Cc1cc(-c2cc3ccccc3s2)cc([N+](=O)[O-])c1O CHEMBL3660422 IC50 420.0 nM
CN(C)C(=O)c1ccc(-c2ccc(O)c(C=O)c2)cc1 CHEMBL3660469 IC50 420.0 nM
COC(=O)c1cccc(-c2ccc(O)c(C=O)c2)c1 CHEMBL3660468 IC50 421.0 nM
O=Cc1c(O)ccc2cnccc12 CHEMBL3665065 IC50 427.0 nM
O=Cc1cc(I)cc(I)c1O CHEMBL3660331 IC50 440.0 nM
O=Cc1cc(-c2ccoc2)ccc1O CHEMBL3660417 IC50 441.0 nM
CN(C)C(=O)c1ccc(-c2cc(F)c(O)c(C=O)c2)cc1 CHEMBL3660473 IC50 455.0 nM
O=Cc1cc(-c2csc3ccccc23)cc(F)c1O CHEMBL3660427 IC50 461.0 nM
COC(=O)c1cccc(-c2cc(F)c(O)c(C=O)c2)c1 CHEMBL3660450 IC50 471.0 nM
C=CCOC(=O)NCc1cc(=O)oc2c(C=O)c(O)ccc12 CHEMBL3265282 IC50 472.0 nM
CC(C)NC(=O)c1cccc(-c2ccc(O)c(C=O)c2)c1 CHEMBL3660476 IC50 491.0 nM
O=Cc1cc(-c2cccc(C(=O)O)c2)cc(F)c1O CHEMBL3660451 IC50 495.0 nM
O=Cc1c(O)ccc2cc(Br)ccc12 CHEMBL3665103 IC50 509.0 nM
COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 CHEMBL491473 Kd 510.0 nM
COc1ccc(-c2cc(C=O)c(O)c([N+](=O)[O-])c2)c(OC)n1 CHEMBL3660332 IC50 510.0 nM
O=Cc1c(Br)ccc(C(=O)N2CCOCC2)c1O CHEMBL3665098 IC50 526.0 nM
Cn1cc(-c2cc(C=O)c(O)c([N+](=O)[O-])c2)cn1 CHEMBL3660399 IC50 535.0 nM
COc1cc(-c2ccc3c(c2)OCCO3)cc(C=O)c1O CHEMBL3660333 IC50 540.0 nM
COc1cc(-c2ccc(C(=O)O)cc2)cc(C=O)c1O CHEMBL3660440 IC50 540.0 nM
Cc1noc(C)c1-c1cc(C=O)c(O)c(C=O)c1 CHEMBL3660334 IC50 550.0 nM
COCc1cccc(-c2cc(C=O)c(O)c(OC)c2)c1 CHEMBL3660335 IC50 570.0 nM
COc1cc(Br)cc(/C=N/c2nnn[nH]2)c1O CHEMBL3665086 IC50 587.0 nM
COc1cc(Br)cc(/C=N/C2N=NN=N2)c1O CHEMBL3910582 IC50 587.0 nM
O=Cc1c(O)ccc2cc(-c3ccc(C(=O)O)cc3)ccc12 CHEMBL3665045 IC50 594.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 600.0 nM
CN(C)C(=O)c1cccc(-c2cc(F)c(O)c(C=O)c2)c1 CHEMBL3660467 IC50 633.0 nM
COc1cc(Br)cc(/C=N/c2nccs2)c1O CHEMBL3665089 IC50 641.0 nM
COc1cc(-c2ccc(C(=O)N3CCOCC3)s2)cc(C=O)c1O CHEMBL3665026 IC50 645.0 nM
O=Cc1c(O)ccc2cc(-c3cccc(C(=O)N4CCOCC4)n3)ccc12 CHEMBL3665055 IC50 645.0 nM
O=Cc1cc(-c2cccc(C(=O)N3CCOCC3)c2)ccc1O CHEMBL3660470 IC50 657.0 nM
Cc1cc(C(=O)Nc2c(Cl)ccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)c2ncnc(N[C@H]3CCCNC3)c2c1 CHEMBL4759055 IC50 670.0 nM
O=Cc1cc(-c2ccsc2)ccc1O CHEMBL3660409 IC50 699.0 nM
Cc1cc(C(=O)Nc2c(Cl)ccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)c2ncnc(N[C@H]3CC[C@H](N)CC3)c2c1 CHEMBL4753081 IC50 700.0 nM
O=Cc1cc(-c2cccs2)cc(C(F)(F)F)c1O CHEMBL3660425 IC50 704.0 nM
O=Cc1cc(Br)cc(Br)c1O CHEMBL229251 IC50 720.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(F)ccc4F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4443828 Kd(free) 723.0 nM
COC(=O)c1cccc(-c2cc(C=O)c(O)c([N+](=O)[O-])c2)c1 CHEMBL3660444 IC50 736.0 nM
COc1cc(-c2ccc(C)s2)cc(C=O)c1O CHEMBL3660379 IC50 743.0 nM
COc1ccc(F)cc1-c1cc(C=O)c(O)c(OC)c1 CHEMBL3660337 IC50 750.0 nM
COc1ccc(-c2cc(C=O)c(O)c(OC)c2)c(F)c1 CHEMBL3660338 IC50 750.0 nM
O=Cc1cc(-c2cncc3ccccc23)cc([N+](=O)[O-])c1O CHEMBL3660395 IC50 754.0 nM
COc1cc(-c2cc(OC)c(OC)c(OC)c2)cc(C=O)c1O CHEMBL3660339 IC50 790.0 nM
COc1cc(-c2cccc(C(=O)N3CCOCC3)c2)cc(C=O)c1O CHEMBL3660431 IC50 795.0 nM
COc1cc(C#Cc2cccs2)cc(C=O)c1O CHEMBL3911792 IC50 799.0 nM
O=Cc1cc(-c2cccnc2)cc(C(F)(F)F)c1O CHEMBL3660392 IC50 800.0 nM
O=Cc1cc(-c2ccoc2)cc(C(F)(F)F)c1O CHEMBL3660474 IC50 800.0 nM
Clc1cc(NCC2CC2)c2ncc(-c3ccc4[nH]c(Nc5ccccc5)nc4c3)n2n1 CHEMBL4585763 IC50 810.0 nM
NC(=O)c1ccc(-c2ccc3c(C=O)c(O)ccc3c2)cc1 CHEMBL3665042 IC50 878.0 nM
Clc1cc(NCC2CC2)c2ncc(-c3ccc4[nH]cnc4c3)n2n1 CHEMBL4576760 IC50 890.0 nM
Cc1cc(O)nc2ccc(O)c(C=O)c12 CHEMBL3665066 IC50 915.0 nM
Cc1cc(C(=O)Nc2c(Cl)ccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)c2ncnc(NCCN)c2c1 CHEMBL4740654 IC50 920.0 nM
COc1cc(-c2cccc3ncccc23)cc(C=O)c1O CHEMBL3660383 IC50 932.0 nM
CCOc1ccc(-c2cc(C=O)c(O)c(OC)c2)cc1 CHEMBL3660340 IC50 990.0 nM
Cc1noc(C)c1-c1cc(F)c(O)c(C=O)c1 CHEMBL3660390 IC50 994.0 nM
Cc1ccc2nc(NCCN)c3ncc(C)n3c2c1 CHEMBL249697 Kd 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM