C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@H]2O CHEMBL135 EC50 0.004 nM
CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 CHEMBL411 EC50 0.007 nM
Oc1cccc(C2=C(Cl)c3cc(O)ccc3O[C@H]2c2ccc(OCCN3CC(CF)C3)cc2)c1 CHEMBL4591338 IC50 0.01 nM
C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1C[C@H]1OC(=O)C[C@]12O CHEMBL5177342 EC50 0.014 nM
CCC(=C(c1ccc(O)cc1)c1ccc(O)cc1)c1ccccc1 CHEMBL149791 EC50 0.015 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1CC1(C)COC1 CHEMBL4867106 DC50 0.02 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1CC(F)(F)CO CHEMBL4871161 DC50 0.02 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OC3CN(CCCF)C3)cc2F)N1CC(F)(F)CO CHEMBL4857736 DC50 0.02 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(NC3CN(CCC(F)F)C3)cc2F)N1CC(F)(F)CO CHEMBL4869698 DC50 0.02 nM
CCCN1CC(Nc2cc(F)c([C@@H]3c4[nH]c5ccccc5c4C[C@@H](C)N3CC(F)(F)CO)c(F)c2)C1 CHEMBL4864829 DC50 0.02 nM
C[C@@H]1Cc2c([nH]c3cc(F)ccc23)[C@@H](c2c(F)cc(NC3CN(CCCF)C3)cc2F)N1CC(F)(F)CO CHEMBL4845726 DC50 0.02 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2ccc(NC3CN(CCCF)C3)cc2F)N1CC(F)(F)CO CHEMBL4865515 DC50 0.02 nM
Oc1ccc2c(c1)OCCC1=C2C(c2ccc(OCCN3CC(CF)C3)cc2)Oc2ccc(O)cc21 CHEMBL4439408 IC50 0.021 nM
CC#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C CHEMBL592868 EC50 0.028 nM
O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12 CHEMBL81 Ki 0.03 nM
CC1=C(c2cccc(O)c2)[C@H](c2ccc(OCCN3CC(CF)C3)cc2)Oc2ccc(O)cc21 CHEMBL4447340 IC50 0.03 nM
CC1=C(c2ccc(F)cc2)[C@H](c2ccc(OCCN3CC(CF)C3)cc2)Oc2ccc(O)c(Cl)c21 CHEMBL4441471 IC50 0.03 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2ccc(OCCN3CC(CF)C3)nc2)N1CC(C)(C)F CHEMBL4852984 DC50 0.03 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1C[C@@](C)(F)CO CHEMBL4854930 DC50 0.03 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OC3CN(CCCO)C3)cc2F)N1CC(F)(F)CO CHEMBL4856892 DC50 0.03 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(NC3CN(CCCF)C3)cc2F)N1CC(F)(F)CO CHEMBL4650316 DC50 0.03 nM
C[C@@H]1Cc2c([nH]c3ccc(F)cc23)[C@@H](c2c(F)cc(NC3CN(CCCF)C3)cc2F)N1CC(F)(F)CO CHEMBL4866043 DC50 0.03 nM
C[C@@H]1Cc2c([nH]c3c(F)cccc23)[C@@H](c2c(F)cc(NC3CN(CCCF)C3)cc2F)N1CC(F)(F)CO CHEMBL4873860 DC50 0.03 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OC3CN(CCCF)C3)cc2F)N1CC(C)(C)F CHEMBL4649161 IC50 0.031 nM
Cc1c(OCCNCCCF)ccc(F)c1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1CC(F)(F)CO CHEMBL5400637 pIC50 0.03162 nM
COc1cc(NC2CN(CCCF)C2)ccc1[C@@H]1c2ccc3[nH]ncc3c2C[C@@H](C)N1CC(C)(F)F CHEMBL4743256 pIC50 0.03981 nM
CCC(=C(c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1 CHEMBL2137046 Ki 0.04 nM
C[C@]12C[C@H](c3ccc(OCCCCCS(=O)(=O)CCCC(F)(F)C(F)(F)F)cc3)[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@H]2O CHEMBL4518283 IC50 0.04 nM
C[C@@H]1Cc2c([nH]c3cccc(F)c23)[C@@H](c2c(F)cc(NC3CN(CCCF)C3)cc2F)N1CC(F)(F)CO CHEMBL4877338 DC50 0.04 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2ccc(NC3CN(CCCF)C3)cc2)N1CC(F)(F)CO CHEMBL4877406 DC50 0.04 nM
Cc1cc(C(=O)CNc2c(-c3ccc(O)cc3)c(=O)oc3cc(O)ccc23)ccc1OCCN1CCC=C(C(=O)O)C1 CHEMBL5199803 Ka 0.04 nM
Nc1ccc(-c2c(C(=O)c3ccc(OCCN4CC(C(=O)O)=CCC4=O)cc3)c3ccc(O)cc3[nH]c2=O)cc1 CHEMBL5181808 Ka 0.04 nM
Oc1ccc2c(c1)OC(c1ccc(OCCN3CC(CF)C3)cc1)C1=C2CCOc2cc(O)ccc21 CHEMBL4464224 IC50 0.045 nM
O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(Cl)cc2)sc2cc(O)ccc12 CHEMBL1193539 IC50 0.046 nM
CC1=C(c2cccc(O)c2)[C@H](c2ccc(OCCN3CC(CF)C3)cc2)Oc2c(O)cccc21 CHEMBL4455953 IC50 0.05 nM
C[C@@H]1Cc2c(ccc3[nH]nc(F)c23)[C@@H](c2ccc(NC3CN(CCCF)C3)c(F)n2)N1CC(F)(F)F CHEMBL4777139 pIC50 0.05012 nM
C[C@@H](COc1ccc(C2Oc3cc(O)ccc3C3=C2c2ccc(O)cc2OCC3)cc1)N1CC[C@@H](CF)C1 CHEMBL4449709 IC50 0.051 nM
Oc1ccc2c(c1)O[C@@H](c1ccc(OCCN3CC(CF)C3)cc1)C1=C2CCOc2cc(O)ccc21 CHEMBL4437985 IC50 0.055 nM
CCC1=C(c2ccc(O)cc2)C(CC)c2cc(O)ccc21 CHEMBL306878 EC50 0.059 nM
Oc1ccc2c(c1)O[C@H](c1ccc(OCCN3CC(CF)C3)cc1)C1=C2CCOc2cc(O)ccc21 CHEMBL4464058 IC50 0.059 nM
C[C@]12CC[C@@H]3c4ccc(O)cc4C[C@@H](CCCCCCCCC[S+]([O-])CCCC(F)(F)C(F)(F)F)[C@H]3[C@@H]1CC[C@@H]2O CHEMBL1358 IC50 0.06 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1CC(C)(C)F CHEMBL4756497 DC50 0.06 nM
Cc1cc(N2Nc3cc(O)ccc3-c3c2c2ccc(O)cc2oc3=O)ccc1OCCN1CCC=C(C(=O)O)C1 CHEMBL5184399 Ka 0.06 nM
COc1cc(NC2CN(CCCF)C2)ccc1[C@@H]1c2ccc3[nH]ncc3c2C[C@@H](C)N1CC(F)(F)F CHEMBL4759597 pIC50 0.0631 nM
CC[C@H](c1ccc(O)cc1)[C@@H](C#N)c1ccc(O)cc1 CHEMBL135739 EC50 0.064 nM
CCCN1CC(Oc2cc(F)c([C@@H]3c4[nH]c5ccccc5c4C[C@@H](C)N3CC(C)(C)F)c(F)c2)C1 CHEMBL4635493 IC50 0.065 nM
Cc1cc(Cl)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(/C=C/C(=O)O)cc1 CHEMBL4081807 EC50 0.07 nM
CC[C@H](C)[C@@H]1NC(=O)[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)CSSC[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(N)=O)NC(=O)[C@H](CC(C)C)NC1=O CHEMBL4240100 Ki 0.07 nM
CC1=C(C2CCCCC2)[C@H](c2ccc(OCCN3CC(CF)C3)cc2)Oc2ccc(O)cc21 CHEMBL4463541 IC50 0.07 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1C(=O)C(C)(C)F CHEMBL4873276 DC50 0.07 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(NC3CN(CCCO)C3)cc2F)N1CC(F)(F)CO CHEMBL4856969 IC50 0.07 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1CC(F)F CHEMBL4847707 DC50 0.07 nM
CNCCOc1ccc(N2Nc3cc(O)ccc3-c3c2c2ccc(O)cc2oc3=O)cc1 CHEMBL5178058 Ka 0.07 nM
O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12 CHEMBL1116 Ki 0.07 nM
Oc1ccc2c(c1)OC(c1ccc(OCCN3CC[C@@H](CF)C3)cc1)C1=C2CCOc2cc(O)ccc21 CHEMBL4539802 IC50 0.076 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1CC(C)(C)F CHEMBL4528514 pIC50 0.07943 nM
COc1cc(OCCNCCCF)ccc1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1CC(F)(F)CO CHEMBL5427353 pIC50 0.07943 nM
Cc1c(OCCNCCCF)ccc(F)c1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1CC(F)(F)F CHEMBL5413311 pIC50 0.07943 nM
CC1=C(c2cn[nH]c2)[C@H](c2ccc(OCCN3CC(CF)C3)cc2)Oc2ccc(O)cc21 CHEMBL4594150 IC50 0.08 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1S(C)(=O)=O CHEMBL4851830 DC50 0.08 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1CC(F)(F)F CHEMBL4858543 DC50 0.08 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1C[C@](C)(F)CO CHEMBL4847664 DC50 0.08 nM
Nc1ccc(-c2c(C(=O)c3ccc(OCCN4CC(C(=O)O)=CCC4=O)cc3)c3ccc(O)cc3oc2=O)cc1 CHEMBL5187730 Ka 0.08 nM
Nc1ccc(-c2c(C(=O)c3ccc(OCCNS(=O)(=O)O)cc3)c3ccc(O)cc3oc2=O)cc1 CHEMBL5195371 Ka 0.08 nM
C#CCN1CC(Oc2cc(F)c([C@@H]3c4[nH]c5ccccc5c4C[C@@H](C)N3CC(C)(C)F)c(F)c2)C1 CHEMBL4646522 IC50 0.083 nM
CCCCCCCCCCCCNCCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1 CHEMBL3805318 IC50 0.09 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC[C@@H](CF)C3)cc2F)N1CC(C)(C)F CHEMBL4644486 IC50 0.09 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(C(F)F)C3)cc2F)N1CC(C)(C)F CHEMBL4648503 IC50 0.09 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1C[C@](C)(F)C#N CHEMBL4850919 DC50 0.09 nM
CC(C)c1ccc(-c2sc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL243970 Ki 0.091 nM
CC/C(=C(\c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1 CHEMBL489 EC50 0.0987 nM
CCCc1c(-c2ccc(O)cc2)nn(-c2ccc(O)cc2)c1-c1ccc(O)cc1 CHEMBL441282 EC50 0.1 nM
Oc1ccc(/C(=N\c2ccccc2Cl)c2ccc(O)cc2O)cc1 CHEMBL3234630 EC50 0.1 nM
Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCC3)cc2)c2ccc(O)cc12 CHEMBL44426 EC50 0.1 nM
CC1=C(c2cccc(O)c2)[C@H](c2ccc(OC[C@H](C)N3CC[C@@H](C)C3)cc2)Oc2ccc(O)cc21 CHEMBL4164133 IC50 0.1 nM
CC1=C(c2ccc(O)cc2)C(c2ccc(OC[C@H](C)N3CC[C@@H](C)C3)cc2)Oc2ccc(O)cc21 CHEMBL4164869 IC50 0.1 nM
CC1=C(c2ccc(F)cc2)[C@H](c2ccc(OCCN3CC(CF)C3)cc2)Oc2ccc(O)cc21 CHEMBL4438260 IC50 0.1 nM
CC1=C(c2cccc(O)c2)[C@H](c2ccc(OC[C@H](C)N3CC[C@@H](CF)C3)cc2)Oc2ccc(O)cc21 CHEMBL4453442 IC50 0.1 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OCCN3CCC(CF)CC3)cc2)Oc2ccc(O)cc21 CHEMBL4563316 IC50 0.1 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OCCN3CC[C@@H](CF)C3)cc2)Oc2ccc(O)cc21 CHEMBL4435067 IC50 0.1 nM
COc1cc(NC2CN(CCCF)C2)ccc1[C@@H]1c2ccc3[nH]ncc3c2C[C@@H](C)N1CC(F)F CHEMBL4758424 pIC50 0.1 nM
C[C@@H]1Cc2c(ccc3[nH]nc(F)c23)[C@@H](c2ncc(NC3CN(CCCF)C3)cc2F)N1CC(F)(F)F CHEMBL4754652 pIC50 0.1 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(NCCN3CC(CF)C3)cc2F)N1CC(F)(F)CO CHEMBL4866232 DC50 0.1 nM
COCC(F)(F)CN1[C@H](c2c(F)cc(NC3CN(CCCF)C3)cc2F)c2[nH]c3ccccc3c2C[C@H]1C CHEMBL4853118 DC50 0.1 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(N3CC(C(N)=O)C3)cc2F)N1CC(C)(C)F CHEMBL5094275 EC50 0.1 nM
O=C(O)c1ccc2c(c1)CCCC(c1ccc(C(F)(F)F)cc1Cl)=C2c1ccc(C=C2CN(CCCF)C2)cc1 CHEMBL5205916 IC50 0.1 nM
O=C(O)c1ccc2c(c1)CCCC(c1ccc(Cl)cc1Cl)=C2c1cc(F)c(C=C2CN(CCCF)C2)c(F)c1 CHEMBL5209281 IC50 0.1 nM
O=C(O)c1ccc2c(c1)CCCC(c1ccc(Cl)c(F)c1Cl)=C2c1ccc(CC2CN(CCCF)C2)cc1 CHEMBL5206519 IC50 0.1 nM
Cc1c(Cl)cccc1C1=C(c2ccc(CC3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 CHEMBL5195598 IC50 0.1 nM
O=C(O)c1ccc2c(c1)CCCC(c1cccc(Cl)c1C(F)(F)F)=C2c1ccc(CC2CN(CCCF)C2)cc1 CHEMBL5185879 IC50 0.1 nM
O=C(O)c1ccc2c(c1)CCCC(c1cccc(F)c1C(F)(F)F)=C2c1ccc(CC2CN(CCCF)C2)cc1 CHEMBL5183360 IC50 0.1 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)ccc(OCCNCCCF)c2F)N1CC(F)(F)CO CHEMBL5421791 pIC50 0.1 nM
CC[C@H](c1ccc(O)cn1)[C@@H](C)c1ccc(O)cc1 CHEMBL538148 EC50 0.11 nM
CC[C@H](c1ccc(O)cn1)[C@@H](CC)c1ccc(O)cc1 CHEMBL556650 EC50 0.11 nM
CC(C)C(=O)N1[C@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)c2[nH]c3ccccc3c2C[C@H]1C CHEMBL4852724 DC50 0.11 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1CC1(F)COC1 CHEMBL4862431 DC50 0.11 nM
CCCn1c(-c2ccc(O)cc2)cc(-c2ccc(O)cc2)c1-c1ccc(O)cc1F CHEMBL2178797 EC50 0.12 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(O[C@H]3CCN(CCCF)C3)cc2F)N1CC(F)(F)CO CHEMBL4845680 DC50 0.12 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(NC3CN(CCCF)C3)cn2)N1CC(F)(F)F CHEMBL4650365 pIC50 0.1259 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(N[C@H]3CCN(CCCF)C3)cn2)N1CC(F)(F)F CHEMBL4780809 pIC50 0.1259 nM
COc1cc(OCCN2CC(CF)C2)ccc1[C@@H]1c2ccc3[nH]ncc3c2C[C@@H](C)N1CC1(F)CC1 CHEMBL4752435 pIC50 0.1259 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ncc(NC3CN(CCCF)C3)cc2F)N1CC(F)(F)CF CHEMBL4799234 pIC50 0.1259 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCNCCCF)cc2F)N1CC(F)(F)CO CHEMBL4868243 pIC50 0.1259 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C CHEMBL691 Ki 0.128 nM
O=C(/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1)N(CCO)CCO CHEMBL4065838 Ki 0.13 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(/C=C/C(=O)O)cc2F)N1CC(C)(C)F CHEMBL3623004 pIC50 0.138 nM
Cc1cc(O)ccc1C1=C(c2ccc(O)cc2C)[C@H]2[C@@H](S(=O)(=O)Oc3ccccc3)C[C@@H]1[S+]2[O-] CHEMBL2031518 EC50 0.14 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2ncc(OCCN3CC(CF)C3)cc2F)N1CC(C)(C)F CHEMBL4869612 DC50 0.14 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(NC(=O)CN3CC(CF)C3)cc2F)N1CC(F)(F)CO CHEMBL4860671 DC50 0.14 nM
CC/C(=C(\c1ccc(O)cc1)c1ccc(/C=C/C(=O)O)cc1)c1ccccc1 CHEMBL195515 pIC50 0.1445 nM
O/N=C/c1ccc(-c2ccccc2)c(-c2ccccc2)c1 CHEMBL335465 Ki 0.15 nM
CCC(=C(c1ccc(O)cc1)c1ccc(O)cc1)c1ccc(O)cc1 CHEMBL37775 EC50 0.15 nM
C=CCN1CC(Oc2cc(F)c([C@@H]3c4[nH]c5ccccc5c4C[C@@H](C)N3CC(C)(C)F)c(F)c2)C1 CHEMBL4644074 IC50 0.15 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1C(=O)C(C)(F)F CHEMBL4867538 DC50 0.15 nM
CC(CN1CCCC2CCCNC21)OCC(=O)N1Nc2cc(O)ccc2C2COc3cc(O)ccc3C21 CHEMBL5191405 Ka 0.15 nM
C[C@@H]1Cc2c(ccc3[nH]ccc23)[C@@H](c2ccc(NC3CN(CCCF)C3)cn2)N1CC(F)(F)F CHEMBL4785486 pIC50 0.1585 nM
CC(C)CN1[C@H](c2ccc(OCCN3CC(CF)C3)cc2)c2ccc3[nH]ncc3c2C[C@H]1C CHEMBL4756831 pIC50 0.1585 nM
COc1cc(OCCN2CC(CF)C2)ccc1[C@@H]1c2ccc3[nH]ncc3c2C[C@@H](C)N1CC(C)(C)F CHEMBL4795387 pIC50 0.1585 nM
COc1cc(OCCNCCCF)ccc1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1CC1(F)COC1 CHEMBL5430945 pIC50 0.1585 nM
COc1cc(OCCNCCCF)ccc1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1CC(F)F CHEMBL5439583 pIC50 0.1585 nM
Cc1c(OCCNCCCF)ncc(F)c1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1C[C@@H](C)C(=O)O CHEMBL5426983 pIC50 0.1585 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1ccc(Cl)cc1C#N CHEMBL4786058 IC50 0.16 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(N[C@H]3CCN(CCCF)C3)cc2F)N1CC(F)(F)CO CHEMBL4874160 DC50 0.16 nM
O=C(c1ccc(OCCN2C=Cc3ccccc3C2)cc1)c1c(-c2ccc(O)cc2)oc(=O)c2cc(O)ccc12 CHEMBL5174813 Ka 0.16 nM
CC1=C(C2CCC(F)(F)CC2)[C@H](c2ccc(OCCN3CC(CF)C3)cc2)Oc2ccc(O)cc21 CHEMBL4447143 IC50 0.17 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OC3CN(CCCCl)C3)cc2F)N1CC(C)(C)F CHEMBL4641732 IC50 0.17 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1ccccc1C CHEMBL4755196 IC50 0.17 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1cccc(F)c1C#N CHEMBL4785851 IC50 0.17 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1ccc(C#N)cc1Cl CHEMBL4778779 IC50 0.17 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(NC3CN(CC(CF)CF)C3)cc2F)N1CC(F)(F)CO CHEMBL4871601 DC50 0.17 nM
O=C(COCN1CCCCC1)CN1Nc2cc(O)ccc2-c2c1c1ccc(O)cc1oc2=O CHEMBL5187253 Ka 0.17 nM
O=C(c1ccc(OCCN2C(=O)CCC2=O)cc1)c1c(-c2ccc(O)cc2)oc(=O)c2cc(O)ccc12 CHEMBL5207726 Ka 0.17 nM
Oc1ccc2c(Oc3ccc(OCCN4CCCCC4)cc3)c(-c3cccc(F)c3)ccc2c1 CHEMBL390021 Ki 0.18 nM
O=C(/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1)NCCO CHEMBL4060067 Ki 0.18 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OC3CN(CCF)C3)cc2F)N1CC(C)(C)F CHEMBL4640902 IC50 0.18 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2ccc(OCCN3CC(CF)C3)cc2)N1S(C)(=O)=O CHEMBL4849978 DC50 0.18 nM
CC1CN(CCOc2cc(F)c([C@@H]3c4[nH]c5ccccc5c4C[C@@H](C)N3CC(C)(C)F)c(F)c2)C1 CHEMBL4633886 IC50 0.19 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2ccc(OCCN3CC(CF)C3)cc2F)N1S(C)(=O)=O CHEMBL4877968 DC50 0.19 nM
COc1cc(/C=C/C(=O)O)cc(F)c1[C@@H]1c2ccc3[nH]ncc3c2C[C@@H](C)N1CC(C)(F)F CHEMBL4583286 pIC50 0.1995 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(N(C)C3CN(CCCF)C3)cn2)N1CC(F)(F)F CHEMBL4751770 pIC50 0.1995 nM
COc1cc(NC2CN(CCCF)C2)ccc1[C@@H]1c2ccc3[nH]ncc3c2C[C@@H](C)N1CC(F)(F)CO CHEMBL4792482 pIC50 0.1995 nM
COc1cc(NC2CN(CCCF)C2)ccc1[C@@H]1c2ccc3[nH]ncc3c2C[C@@H](C)N1CC(C)(C)F CHEMBL4751971 pIC50 0.1995 nM
CC(C)CN1[C@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)c2ccc3[nH]ncc3c2C[C@H]1C CHEMBL4759688 pIC50 0.1995 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(NC3CN(CCCF)C3)c(F)n2)N1CC(F)(F)F CHEMBL4749445 pIC50 0.1995 nM
C[C@@H]1Cc2c(cc(F)c3[nH]ncc23)[C@@H](c2ccc(NC3CN(CCCF)C3)cn2)N1CC(F)(F)F CHEMBL4789498 pIC50 0.1995 nM
COc1ccc(OCCNCCCF)cc1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1CC(F)F CHEMBL5399407 pIC50 0.1995 nM
COc1ccc(OCCNCCCF)cc1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1CC(F)(F)CO CHEMBL5432698 pIC50 0.1995 nM
C[C@@H](COc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1)N1CCCC1 CHEMBL198803 IC50 0.2 nM
Oc1ccc2c(Oc3ccc(OCCN4CCCCC4)cc3)c(-c3ccc(F)c(F)c3)ccc2c1 CHEMBL244206 Ki 0.2 nM
Oc1ccc2c(c1)O[C@H](c1ccc(OCCN3CCCCC3)cc1)C1=C2CCOc2cc(O)ccc21 CHEMBL1088485 IC50 0.2 nM
C[C@H](COc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1)N1CCCC1 CHEMBL2024377 IC50 0.2 nM
CCCn1c(-c2ccc(O)cc2F)cc(-c2ccc(O)cc2F)c1-c1ccc(O)cc1F CHEMBL2178793 EC50 0.2 nM
COc1ccc(-c2sc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL226267 EC50 0.2 nM
O=C(c1ccc(O)cc1)c1sc2cc(O)ccc2c1-c1ccc(F)cc1 CHEMBL3763189 EC50 0.2 nM
CC(F)(F)c1ccccc1-c1sc2cc(O)ccc2c1Oc1ccc(/C=C/C(=O)O)cc1 CHEMBL4069711 IC50 0.2 nM
CC(F)(F)c1cc(F)ccc1-c1sc2cc(O)ccc2c1Oc1ccc(/C=C/C(=O)O)cc1 CHEMBL4076124 IC50 0.2 nM
Oc1ccc2c(c1)CCCC(C1CCC(O)CC1)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4165845 IC50 0.2 nM
Oc1ccc2c(c1F)CCCC(c1ccc(OC(F)F)cc1F)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4160292 IC50 0.2 nM
COc1ccc(C2=C(c3ccc(O[C@H]4CCN(CCCF)C4)cc3)c3ccc(O)cc3CCC2)c(C)c1 CHEMBL4177307 IC50 0.2 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OCCN3CCCCC3)cc2)Oc2ccc(O)cc21 CHEMBL4163162 IC50 0.2 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OCCN3CCCCCC3)cc2)Oc2ccc(O)cc21 CHEMBL4171078 IC50 0.2 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OCCN3CC[C@H](C)C3)cc2)Oc2ccc(O)cc21 CHEMBL4163562 IC50 0.2 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OCCN3CCC(C)CC3)cc2)Oc2ccc(O)cc21 CHEMBL4176563 IC50 0.2 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OC[C@H](C)N3CCCCC3)cc2)Oc2ccc(O)cc21 CHEMBL4168008 IC50 0.2 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OC[C@H](C)N3CCCCCC3)cc2)Oc2ccc(O)cc21 CHEMBL4164447 IC50 0.2 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OC[C@H](C)N3CC[C@@H](C)C3)cc2)Oc2ccc(O)cc21 CHEMBL4175085 IC50 0.2 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OC[C@H](C)N3CC[C@H](C)C3)cc2)Oc2ccc(O)cc21 CHEMBL4171332 IC50 0.2 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OC[C@@H](C)N3CC[C@H](C)C3)cc2)Oc2ccc(O)cc21 CHEMBL4174789 IC50 0.2 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OC[C@H](C)N3CC[C@@H](C)C3)cc2)Oc2cc(O)ccc21 CHEMBL4167575 IC50 0.2 nM
O=C(O)c1ccc2c(c1)CCCC(c1ccc(Cl)cc1Cl)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4475463 EC50 0.2 nM
Oc1ccc2c(c1)CCCC(c1cccnc1)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4524901 EC50 0.2 nM
Oc1ccc2c(c1)CCCC(c1ccncc1)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4516970 EC50 0.2 nM
Oc1ccc2c(c1)CCCC(c1ccc(Cl)cc1F)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4564257 EC50 0.2 nM
CCCN1CC(Oc2ccc(C3=C(c4ccc(O)cc4)CCc4ccc(O)cc43)cc2)C1 CHEMBL4572640 EC50 0.2 nM
CC1=C(c2ccc(C#N)cc2)C(c2ccc(OCCN3CC(CF)C3)cc2)Oc2ccc(O)cc21 CHEMBL4464718 IC50 0.2 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OC[C@H](C)N3CC[C@@H](CF)C3)cc2)Oc2ccc(O)cc21 CHEMBL4438992 IC50 0.2 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OC[C@H](C)N3CC(CF)C3)cc2)Oc2ccc(O)cc21 CHEMBL4576272 IC50 0.2 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OCCN3CCC[C@H]3CF)cc2)Oc2ccc(O)cc21 CHEMBL4461269 IC50 0.2 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OCCN3CC[C@@H](C(F)F)C3)cc2)Oc2ccc(O)cc21 CHEMBL4438826 IC50 0.2 nM
COC/C=C/C1=C(C)c2cc(O)ccc2O[C@H]1c1ccc(OCCN2CC(CF)C2)cc1 CHEMBL4476031 IC50 0.2 nM
CC1=C(c2ccc(F)cc2)[C@H](c2ccc(OCCN3CC(CF)C3)cc2)Oc2ccc(O)c(F)c21 CHEMBL4567402 IC50 0.2 nM
Cc1cc(F)ccc1C1=C(c2ccc(C=C3CN(CCC(F)F)C3)cc2)c2ccc(C(=O)O)cc2CCC1 CHEMBL5171498 IC50 0.2 nM
Cc1cc(C2CC2)ccc1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 CHEMBL5208061 IC50 0.2 nM
O=C(O)c1ccc2c(c1)CCCC(c1cc(C(F)(F)F)ccc1C(F)(F)F)=C2c1ccc(C=C2CN(CCCF)C2)cc1 CHEMBL5177732 IC50 0.2 nM
Oc1ccc2c(c1)CCCC(c1ccc(Cl)cc1Cl)=C2c1ccc(C=C2CN(CCCF)C2)cc1 CHEMBL5174256 IC50 0.2 nM
O=C(O)c1ccc2c(c1)CCCC(c1cccc(F)c1C(F)(F)F)=C2c1ccc(CC2CN(CCC(F)F)C2)cc1 CHEMBL5199211 IC50 0.2 nM
O=C(O)c1ccc2c(c1)CCCC(CC1CCC1)=C2c1ccc(CC2CN(CCCF)C2)cc1 CHEMBL5174012 IC50 0.2 nM
Oc1cccc(-c2ccc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)c1 CHEMBL390020 Ki 0.21 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OC[C@H](C)N3CC[C@@H](CF)C3)cc2F)N1CC(C)(C)F CHEMBL4645364 IC50 0.21 nM
O=C(c1ccc(N2CCN(c3ccc(Cl)cc3)CC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12 CHEMBL178679 IC50 0.22 nM
O=C(c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3)CC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12 CHEMBL180707 IC50 0.22 nM
CC(=O)N1C(C)(C)CC(=C(c2ccc(O)cc2)c2ccc(O)cc2)CC1(C)C CHEMBL3753254 EC50 0.22 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1ccc(OC)cc1 CHEMBL4742066 IC50 0.22 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(N3CC(CF)C3)cc2F)N1CC(C)(C)F CHEMBL5083902 EC50 0.22 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CCC21C CHEMBL1627464 Ki 0.23 nM
C[C@@H]1CC2c3ccccc3NC2[C@@H](c2c(F)cc(/C=C/C(=O)O)cc2F)N1CC(C)(C)F CHEMBL5085311 EC50 0.23 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(N3CC4(COC4)C3)cc2F)N1CC(C)(C)F CHEMBL5094923 EC50 0.23 nM
Oc1ccc2c(Oc3ccc(OCCN4CCCCC4)cc3)c(-c3ccc(F)cc3)ccc2c1 CHEMBL244205 Ki 0.24 nM
N#Cc1cccc(-c2ccc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)c1 CHEMBL243999 Ki 0.24 nM
C[C@]12CC[C@@H]3c4ccc(/C=C/C(=O)O)cc4CC[C@H]3[C@@H]1CC[C@@H]2O CHEMBL1222144 EC50 0.24 nM
Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(/C=C/C(=O)O)cc1 CHEMBL4059888 EC50 0.24 nM
Oc1ccc2c(c1)C1=C(c3cc(O)ccc3OCC1)C(c1ccc(OCCN3CC(CF)C3)cc1)O2 CHEMBL4443826 IC50 0.24 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1ccccc1C#N CHEMBL4745817 IC50 0.24 nM
Cc1cc(C(=O)C2=C(c3ccc(O)cc3)COc3cc(O)ccc32)ccc1OCCN1C=Cc2cccnc2C1 CHEMBL5203282 Ka 0.24 nM
CCCCc1ccc(-c2sc3cc(O)ccc3c2C(=O)c2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL46937 Ki 0.25 nM
C[C@@H]1Cc2cc(O)ccc2[C@@H](c2c(F)cc(/C=C/C(=O)O)cc2F)N1CC(C)(C)F CHEMBL3774584 IC50 0.25 nM
COc1cc(-c2cc(F)c([C@@H]3c4[nH]c5ccccc5c4C[C@@H](C)N3CC(C)(C)F)c(F)c2)ccc1C(=O)O CHEMBL5072998 EC50 0.25 nM
Cc1cc(C(=O)C2=C(c3ccc(O)cc3)COc3cc(O)ccc32)ccc1OCCN1Cc2cccnc2C1 CHEMBL5178110 Ka 0.25 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@](C)(c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1CC(C)(C)F CHEMBL4591926 pIC50 0.2512 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2c(F)cc(/C=C/C(=O)O)cc2F)N1CC(C)(C)F CHEMBL4448852 pIC50 0.2512 nM
COc1cc(OCCN2CC(CF)C2)ccc1[C@@H]1c2ccc3[nH]ncc3c2C[C@@H](C)N1CC1(F)COC1 CHEMBL4777960 pIC50 0.2512 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ncc(NC3CN(CCCF)C3)cc2F)N1CC(F)(F)F CHEMBL4789223 pIC50 0.2512 nM
COc1ccc(OCCNCCCF)cc1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1CC1(F)COC1 CHEMBL5428933 pIC50 0.2512 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2cc(OCCNCCCF)ccc2F)N1CC(F)(F)F CHEMBL5398790 pIC50 0.2512 nM
Cc1ccccc1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(OCCN2CC(C)C2)cc1 CHEMBL4527655 pIC50 0.257 nM
C[C@@H]1Cc2c([nH]c3cccnc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1CC(C)(C)F CHEMBL4854999 DC50 0.26 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(-n3ccc(C(=O)O)n3)cc2F)N1CC(C)(C)F CHEMBL5084593 EC50 0.26 nM
Cc1cccc(C(=O)N2CCN(c3ccc(C(=O)c4c(-c5ccc(O)cc5)sc5cc(O)ccc45)cc3)CC2)c1 CHEMBL180873 IC50 0.27 nM
CCCn1c(-c2ccc(O)cc2F)cc(-c2ccc(O)cc2)c1-c1ccc(O)cc1F CHEMBL2178792 EC50 0.27 nM
NC(=O)/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1 CHEMBL4079530 Ki 0.27 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(NCCNCCCF)cc2F)N1CC(F)(F)CO CHEMBL4862453 DC50 0.27 nM
Oc1ccc2c(c1)CN(c1ccc(OCCN3CCCCC3)cc1)c1c-2ccc2cc(O)ccc12 CHEMBL12987 Ki 0.28 nM
CC(C)N1CCN(c2ccc(C(=O)c3c(-c4ccc(O)cc4)sc4cc(O)ccc34)cc2)CC1 CHEMBL178334 IC50 0.28 nM
CC1=C(C2CCC(O)CC2)[C@H](c2ccc(OCCN3CC(CF)C3)cc2)Oc2ccc(O)cc21 CHEMBL4450730 IC50 0.28 nM
Oc1ccc2c(c1)OC(c1ccc(OCCN3CCCCC3)cc1)C1=C2CCOc2cc(O)ccc21 CHEMBL1087419 IC50 0.28 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1ccccc1 CHEMBL4791503 IC50 0.28 nM
C[C@@H]1c2c(ccc(O)c2F)O[C@@H](c2ccc(OCCN3CCCCCC3)cc2)[C@H]1c1ccc(O)cc1 CHEMBL181368 IC50 0.3 nM
CC(C)[C@H]1CCN(CCOc2ccc([C@@H]3Oc4ccc(O)cc4S[C@@H]3c3ccc(O)cc3)cc2)C1 CHEMBL427324 IC50 0.3 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3C[C@H]4CCC[C@H]4C3)cc2)cc1 CHEMBL433769 IC50 0.3 nM
Oc1ccc2c3c(ccc2c1)-c1cc(F)cc(F)c1O[C@@H]3c1ccc(OCCN2CCCCC2)cc1 CHEMBL535158 Ki 0.3 nM
O/N=C/c1c(O)ccc(-c2ccc(O)cc2)c1-c1ccc(O)cc1 CHEMBL1782956 EC50 0.3 nM
COc1ccc(C2=C(c3ccccc3)CCCc3cc(O)ccc32)cc1 CHEMBL3290284 EC50 0.3 nM
CCOc1ccc(C2=C(c3ccccc3)CCCc3cc(O)ccc32)cc1 CHEMBL3290282 EC50 0.3 nM
CC(F)c1ccccc1-c1sc2cc(O)ccc2c1Oc1ccc(/C=C/C(=O)O)cc1 CHEMBL4091432 IC50 0.3 nM
Cc1nc2ccc(C3=C(c4ccc(O[C@H]5CCN(CCCF)C5)cc4)c4ccc(O)cc4CCC3)cc2o1 CHEMBL4170904 IC50 0.3 nM
COc1ccc(C2=C(c3ccc(O[C@H]4CCN(CCCF)C4)cc3)c3ccc(O)cc3CCC2)cc1F CHEMBL4169457 IC50 0.3 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OCCN3CCC3)cc2)Oc2ccc(O)cc21 CHEMBL4161695 IC50 0.3 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OCCN3CC(C)C3)cc2)Oc2ccc(O)cc21 CHEMBL4165523 IC50 0.3 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OC[C@@H](C)N3CCCC3)cc2)Oc2ccc(O)cc21 CHEMBL4169918 IC50 0.3 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OC[C@@H](C)N3CC[C@@H](C)C3)cc2)Oc2ccc(O)cc21 CHEMBL4160734 IC50 0.3 nM
CC1=C(c2ccc(O)cc2)C(c2ccc(OC[C@H](C)N3CC[C@@H](C)C3)cc2)Oc2cc(O)ccc21 CHEMBL4175179 IC50 0.3 nM
Oc1ccc2c(c1)CCCC(c1ccc(F)cc1Cl)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4475039 EC50 0.3 nM
Oc1ccc2c(c1)C(c1ccc(O[C@H]3CCN(CCCF)C3)cc1)=C(c1ccc(F)cc1Cl)CCC2 CHEMBL4527764 EC50 0.3 nM
Oc1ccc(C2=C(c3ccc(O[C@H]4CCN(CCCF)C4)cc3)c3cc(O)ccc3CC2)cc1 CHEMBL4533966 EC50 0.3 nM
COc1ccc(/C(=C(\c2ccc(/C=C/C(=O)O)cc2)c2ccc3nccn3c2)C2CCC2)c(Cl)c1 CHEMBL4474820 EC50 0.3 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OCCN3CC(CF)C3)cc2)Oc2ccc(O)cc21 CHEMBL4524752 IC50 0.3 nM
COC[C@@H]1CCN(CCOc2ccc(C3Oc4ccc(O)cc4C(C)=C3c3cccc(O)c3)cc2)C1 CHEMBL4574167 IC50 0.3 nM
COc1cc(N2CCN(CCC3(O)CC(Oc4ccc([C@@H]5c6ccc(O)cc6CC[C@@H]5c5ccccc5)cc4)C3)CC2)cc2c1C(=O)N(C1CCC(=O)NC1=O)C2 CHEMBL4456119 IC50 0.3 nM
CC1=C(c2ccc(N)nc2)[C@H](c2ccc(OCCN3CC(CF)C3)cc2)Oc2ccc(O)cc21 CHEMBL4588281 IC50 0.3 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(-c3ccc(C(=O)O)cc3)cc2F)N1CC(C)(C)F CHEMBL5090655 EC50 0.3 nM
CC1=C(c2cc(F)cc(F)c2)[C@H](c2ccc(/C=C/CN3CC(CF)C3)cc2)Oc2cc(O)ccc21 CHEMBL5095057 IC50 0.3 nM
CCC1=C(c2ccc(O)cc2)Cc2cc(O)ccc21 CHEMBL69408 EC50 0.31 nM
CCCn1c(-c2ccc(O)cc2)cc(-c2ccc(O)cc2)c1-c1ccc(O)cc1Cl CHEMBL2179253 EC50 0.31 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@](C)(c2c(F)cc(/C=C/C(=O)O)cc2F)N1CC(C)(F)F CHEMBL4436390 pIC50 0.3162 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(/C=C/C(=O)O)cc2)N1CC(C)(C)F CHEMBL4515724 pIC50 0.3162 nM
COc1cc(/C=C/C(=O)O)c(F)cc1[C@@H]1c2ccc3[nH]ncc3c2C[C@@H](C)N1CC(C)(F)F CHEMBL4586022 pIC50 0.3162 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(NC3CN(CCCF)C3)cn2)N1CC(F)F CHEMBL4754747 pIC50 0.3162 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(NC3CN(CCCF)C3)cn2)N1CC(C)(F)F CHEMBL4749269 pIC50 0.3162 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(NC3CN(CCCF)C3)cn2)N1CC(C)(C)F CHEMBL4753585 pIC50 0.3162 nM
COc1cc(NC2CN(CCCF)C2)ccc1[C@@H]1c2ccc3[nH]ncc3c2C[C@@H](C)N1CC1(F)CC1 CHEMBL4742862 pIC50 0.3162 nM
COc1cc(OCCNCCCF)ccc1[C@@H]1c2ccc3[nH]ncc3c2C[C@@H](C)N1CC1(F)CC1 CHEMBL4792890 pIC50 0.3162 nM
Cc1c(OCCNCCCF)cccc1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1CC(F)(F)F CHEMBL5423660 pIC50 0.3162 nM
Cc1c(OCCN(C)CCCF)ncc(F)c1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1C[C@@H](C)C(=O)O CHEMBL5420450 pIC50 0.3162 nM
Cc1c(OCCN(C)CCCF)ncc(F)c1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1C[C@H](C)C(=O)O CHEMBL5408358 pIC50 0.3162 nM
Oc1ccc(-c2ccc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL244000 Ki 0.32 nM
NCCCCNC(=O)/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1 CHEMBL4083780 Ki 0.32 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OC3CN(CCCF)C3)cc2F)N1C(=O)C1(F)CC1 CHEMBL4846893 DC50 0.32 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1C(=O)[C@@H](C)CF CHEMBL4856729 DC50 0.34 nM
COc1cc(-c2ccc(C(=O)O)cn2)cc(F)c1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1CC(C)(C)F CHEMBL5082416 EC50 0.34 nM
Oc1ccc([C@H]2Oc3cccc(O)c3[C@H]3CCC[C@H]32)cc1 CHEMBL234638 Ki 0.35 nM
CN(C)CCNC(=O)/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1 CHEMBL4070669 Ki 0.35 nM
CC(C)(F)CN1C2CCCC2c2c([nH]c3ccccc23)[C@H]1c1c(F)cc(/C=C/C(=O)O)cc1F CHEMBL5080204 EC50 0.35 nM
CCc1c(-c2ccc(OCCN3CCCCC3)cc2)oc(-c2ccc(O)cc2)c1-c1ccc(O)cc1 CHEMBL315474 Ki 0.36 nM
O=C(/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1)NCCCCO CHEMBL4102857 Ki 0.36 nM
C[C@H](CF)CN1[C@H](c2c(F)cc(/C=C/C(=O)O)cc2F)c2ccc(O)cc2C[C@H]1C CHEMBL3775908 IC50 0.37 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1ccc2[nH]ncc2c1)c1ccc(F)cc1Cl CHEMBL3581693 Ki 0.37 nM
CN(CCO)C(=O)/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1 CHEMBL4099302 Ki 0.37 nM
NCCCNC(=O)/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1 CHEMBL4062045 Ki 0.37 nM
O=C(/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1)OCCO CHEMBL4079644 Ki 0.37 nM
COc1cc(N2CCN(CCCCCOc3ccc([C@@H]4c5ccc(O)cc5CC[C@@H]4c4ccccc4)cc3)CC2)cc2c1C(=O)N([C@@H]1CCC(=O)NC1=O)C2 CHEMBL4537710 IC50 0.37 nM
CC#CC(Cc1ccc(O)cc1)c1ccc(O)cc1 CHEMBL136039 EC50 0.38 nM
CCCNS(=O)(=O)/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1 CHEMBL4097562 Ki 0.38 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(F)(CF)C3)cc2F)N1CC(C)(C)F CHEMBL4644611 IC50 0.38 nM
C[C@]12CC[C@]3(C#N)c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@H]2O CHEMBL4782490 EC50 0.38 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OC3CN(CCCCF)C3)cc2F)N1CC(C)(C)F CHEMBL4641773 IC50 0.39 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@](C)(c2c(F)cc(/C=C/C(=O)O)cc2F)N1CC(C)(C)F CHEMBL4447306 pIC50 0.3981 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2c(F)cc(/C=C/C(=O)O)cc2F)N1CC(C)(F)F CHEMBL4436187 pIC50 0.3981 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@](C)(c2c(F)cc(/C=C/C(=O)O)cc2F)N1CC(C)(C)F CHEMBL4584370 pIC50 0.3981 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(O[C@H]3CCN(CCCF)C3)cn2)N1CC(F)(F)F CHEMBL4779715 pIC50 0.3981 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(OCCN3CC(CF)C3)cn2)N1CC(F)(F)F CHEMBL4782483 pIC50 0.3981 nM
COc1cc(OC2CN(CCCF)C2)ccc1[C@@H]1c2ccc3[nH]ncc3c2C[C@@H](C)N1CC1(F)CC1 CHEMBL4750007 pIC50 0.3981 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(OCCN3CC(CF)C3)cn2)N1CC1(F)CC1 CHEMBL4757886 pIC50 0.3981 nM
CC(C)CN1[C@H](c2ccc(OCCN3CC(CF)C3)cn2)c2ccc3[nH]ncc3c2C[C@H]1C CHEMBL4762458 pIC50 0.3981 nM
Cc1c(OCCN(C)CCCF)ccc(F)c1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1C[C@H](C)C(=O)O CHEMBL5440088 pIC50 0.3981 nM
Cc1c(OCCNCCCF)ncc(F)c1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1C[C@H](C)C(=O)O CHEMBL5426160 pIC50 0.3981 nM
C[C@@H]1CN(CCOc2ccc([C@@H]3Oc4ccc(O)cc4S[C@@H]3c3ccc(O)cc3)cc2)C[C@H]1C CHEMBL183467 IC50 0.4 nM
CC(C)[C@@H]1CCN(CCOc2ccc([C@@H]3Oc4ccc(O)cc4S[C@@H]3c3ccc(O)cc3)cc2)C1 CHEMBL361601 IC50 0.4 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CC4(CCC4)C3)cc2)cc1 CHEMBL185083 IC50 0.4 nM
Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OC[C@H](C)N3CCCC3)cc2)c2ccc(O)cc12 CHEMBL372808 IC50 0.4 nM
CN(C)S(=O)(=O)c1ccc(-c2ccc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL243571 Ki 0.4 nM
CCCn1c(-c2ccc(O)cc2)cc(-c2ccc(O)cc2)c1-c1ccc(O)cc1 CHEMBL2178795 EC50 0.4 nM
Cc1cc(F)ccc1-c1c(Oc2ccc(/C=C/C(=O)O)cc2)c2ccc(O)cc2oc1=O CHEMBL3427401 IC50 0.4 nM
C/C(=C(/c1ccc(O)cc1)c1ccc(OCCN2CCCCC2)cc1)c1ccccc1 CHEMBL3774647 IC50 0.4 nM
C[C@H](CF)CN1[C@H](c2ccc(/C=C/C(=O)O)cc2)c2ccc(O)cc2C[C@H]1C CHEMBL3774690 IC50 0.4 nM
CC1(c2ccc(/C=C/C(=O)O)cc2)c2ccc(O)cc2CCN1c1ccc(C2CC2)cc1 CHEMBL4093325 IC50 0.4 nM
CC(C)Cc1ccc(N2CCc3cc(O)ccc3C2(C)c2ccc(/C=C/C(=O)O)cc2)c(F)c1 CHEMBL4088736 IC50 0.4 nM
O=C(O)/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1 CHEMBL4083658 Ki 0.4 nM
CC(C)c1ccccc1-c1sc2cc(O)ccc2c1Oc1ccc(/C=C/C(=O)O)cc1 CHEMBL4082510 IC50 0.4 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OCCN3CCCC3)cc2)Oc2ccc(O)cc21 CHEMBL4169627 IC50 0.4 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OCCN3CC[C@@H](C)C3)cc2)Oc2ccc(O)cc21 CHEMBL4161455 IC50 0.4 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OC[C@H](C)N3CCCC3)cc2)Oc2ccc(O)cc21 CHEMBL4162508 IC50 0.4 nM
CC1=C(c2ccccc2)C(c2ccc(OC[C@H](C)N3CC[C@@H](C)C3)cc2)Oc2ccc(O)cc21 CHEMBL4169959 IC50 0.4 nM
CC1=C(c2ccc(F)cc2)C(c2ccc(OC[C@H](C)N3CC[C@@H](C)C3)cc2)Oc2ccc(O)cc21 CHEMBL4167152 IC50 0.4 nM
Oc1ccc(C2=C(c3ccc(O[C@H]4CCN(CCCF)C4)cc3)c3cc(O)ccc3CCC2)cc1 CHEMBL4540897 EC50 0.4 nM
N#Cc1cc(Cl)ccc1/C(=C(\c1ccc(/C=C/C(=O)O)cc1)c1ccc2scnc2c1)C1CCC1 CHEMBL4527199 EC50 0.4 nM
COc1ccc(/C(=C(\c2ccc(/C=C/C(=O)O)cc2)c2ccc3scnc3c2)C2CCC2)c(Cl)c1 CHEMBL4464136 EC50 0.4 nM
CC1=C(c2ccc(F)cc2)C(c2ccc(OCCN3CC(CF)C3)cc2)Oc2ccc(O)cc21 CHEMBL4454014 IC50 0.4 nM
O=C(NCCCCOc1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1)C1CCCCC1 CHEMBL4208017 IC50 0.4 nM
C[C@H](CF)C(=O)N1[C@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)c2[nH]c3ccccc3c2C[C@H]1C CHEMBL4847278 DC50 0.4 nM
CC(F)(F)c1cc(F)ccc1-c1sc2c(ccc3[nH]ncc32)c1Oc1ccc(OCCN2CC(CC#N)C2)cc1 CHEMBL5193428 EC50 0.4 nM
COc1cc(Oc2c(-c3ccc(F)cc3C(C)(F)F)sc3c2ccc2[nH]ncc23)ccc1OC1CN(CCCF)C1 CHEMBL5181850 EC50 0.4 nM
CC(C)CN1[C@H](c2c(F)cc(/C=C/C(=O)O)cc2F)c2[nH]c3ccccc3c2C[C@H]1C CHEMBL3623002 pIC50 0.4169 nM
CC1=C(c2ccc(F)cc2)[C@H](c2ccc(OCCN3CC(CF)C3)cc2)Oc2c(O)cccc21 CHEMBL4456532 IC50 0.42 nM
O=C(/C=C/c1ccc(C(=C2CCCCC2)c2ccc(O)cc2)cc1)NCCCCNC(=O)/C=C/c1ccc(C(=C2CCCCC2)c2ccc(O)cc2)cc1 CHEMBL4761289 IC50 0.42 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OC3CN(CCCF)C3)cc2F)N1C(=O)C(C)(C)F CHEMBL4873782 DC50 0.42 nM
O=C(c1ccc(N2CCN(c3ccc([N+](=O)[O-])cc3)CC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12 CHEMBL180176 IC50 0.43 nM
O=C(/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1)NCCCO CHEMBL4078577 Ki 0.43 nM
COC(=O)/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1 CHEMBL4060817 Ki 0.43 nM
COc1cc(-c2cc(F)c([C@@H]3c4[nH]c5ccccc5c4C[C@@H](C)N3CC(C)(C)F)c(Cl)c2)ccc1C(=O)O CHEMBL5070426 EC50 0.43 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1ccccc1Cl CHEMBL4763497 IC50 0.44 nM
O=C(/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1)OCCCCO CHEMBL4089824 Ki 0.45 nM
O=C(c1ccc(N2CCN(C(=O)c3cccc(Cl)c3)CC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12 CHEMBL178665 IC50 0.46 nM
CCNc1c(/C=N/O)ccc(-c2ccccc2)c1-c1ccccc1 CHEMBL128227 Ki 0.47 nM
CS(=O)(=O)c1ccc(-c2ccc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL243789 Ki 0.47 nM
CCS(=O)(=O)c1ccc(-c2sc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL395291 Ki 0.48 nM
COc1cc(/C=C/C(=O)O)cc(F)c1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1CC(C)(C)F CHEMBL5082333 EC50 0.48 nM
C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1C[C@@H](O)[C@@H]2O CHEMBL193482 Ki 0.483 nM
COc1cc(N2CCN(CCCCCOc3ccc([C@@H]4c5ccc(O)cc5CC[C@@H]4c4ccccc4)cc3)CC2)cc2c1C(=O)N([C@H]1CCC(=O)NC1=O)C2 CHEMBL4458123 IC50 0.49 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1C(=O)C(C)(C)C CHEMBL4860993 DC50 0.49 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(-c3cnc(C(=O)O)s3)cc2F)N1CC(C)(C)F CHEMBL5077153 EC50 0.49 nM
Oc1ccc2c(c1)CCC(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1 CHEMBL92748 IC50 0.5 nM
Oc1ccc([C@@H]2Sc3c(F)cc(O)cc3O[C@@H]2c2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL94030 IC50 0.5 nM
C[C@@H]1c2c(ccc(O)c2F)O[C@@H](c2ccc(OC[C@H](C)N3CCCC3)cc2)[C@H]1c1ccc(O)cc1 CHEMBL359633 IC50 0.5 nM
C[C@H]1CN(CCOc2ccc([C@@H]3Oc4ccc(O)cc4S[C@@H]3c3ccc(O)cc3)cc2)C[C@@H]1C CHEMBL182980 IC50 0.5 nM
CC[C@@H](COc1ccc([C@@H]2Oc3ccc(O)cc3S[C@@H]2c2ccc(O)cc2)cc1)N1CCCC1 CHEMBL367350 IC50 0.5 nM
CC(C)[C@H](COc1ccc([C@@H]2Oc3ccc(O)cc3S[C@@H]2c2ccc(O)cc2)cc1)N1CCCC1 CHEMBL182794 IC50 0.5 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CC[C@@H]4C[C@@H]43)cc2)cc1 CHEMBL181862 IC50 0.5 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CC[C@@H](F)C3)cc2)cc1 CHEMBL184679 IC50 0.5 nM
Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CC[C@@H](C)C3)cc2)c2ccc(O)cc12 CHEMBL198914 IC50 0.5 nM
C[C@@H]1CCN(CCOc2ccc([C@@H]3c4ccc(O)cc4CC[C@@H]3c3ccccc3)cc2)C1 CHEMBL437695 IC50 0.5 nM
Cc1cc(OC(F)(F)F)ccc1-c1c(Oc2ccc(/C=C/C(=O)O)cc2)c2ccc(O)cc2oc1=O CHEMBL3427402 IC50 0.5 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1ccc2[nH]ncc2c1)c1cscc1C CHEMBL3581681 EC50 0.5 nM
Cc1ccc(C(=O)c2sc3cc(O)ccc3c2Oc2ccc(/C=C/C(=O)O)cc2)c(C)c1 CHEMBL4070169 Ki 0.5 nM
CC1(c2ccc(/C=C/C(=O)O)cc2)c2ccc(O)cc2CCN1c1ccc(CC(F)(F)F)cc1 CHEMBL4098286 IC50 0.5 nM
Oc1ccc2c(c1)C(c1ccc(OCCN3CCCCC3)cc1)c1c(sc3cc(O)ccc13)C2 CHEMBL4171598 Ki 0.5 nM
CC1=C(c2cccc(F)c2)C(c2ccc(OC[C@H](C)N3CC[C@@H](C)C3)cc2)Oc2ccc(O)cc21 CHEMBL4165638 IC50 0.5 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCOc2cc(F)c([C@@H]3c4[nH]c5ccccc5c4C[C@@H](C)N3CC(C)(C)F)c(F)c2)C(C)(C)C)cc1 CHEMBL4581069 IC50 0.5 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCC(F)(F)CCOc2cc(F)c([C@@H]3c4[nH]c5ccccc5c4C[C@@H](C)N3CC(C)(C)F)c(F)c2)C(C)(C)C)cc1 CHEMBL4444805 IC50 0.5 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCCCCOc2cc(F)c([C@@H]3c4[nH]c5ccccc5c4C[C@@H](C)N3CC(C)(C)F)c(F)c2)C(C)(C)C)cc1 CHEMBL4578800 IC50 0.5 nM
Oc1ccc2c(c1)CCCC(c1ccc3[nH]ccc3c1)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4533909 EC50 0.5 nM
Oc1ccc2c(c1)CCCC(c1cccc(Cl)c1F)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4452445 EC50 0.5 nM
Oc1ccc2c(c1)CCCC(c1cccc(F)c1Cl)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4438317 EC50 0.5 nM
Oc1ccc2c(c1)CCCC(c1ccccc1)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4524856 EC50 0.5 nM
O=C(c1ccccc1)c1sc2cc(O)ccc2c1Oc1ccc(OC2CN(CCCF)C2)cc1 CHEMBL4586663 IC50 0.5 nM
O=C1CCC(N2Cc3cc(N4CCN(CCC5(O)CC(Oc6ccc([C@@H]7c8ccc(O)cc8CC[C@@H]7c7ccccc7)cc6)C5)CC4)cc(OC(F)F)c3C2=O)C(=O)N1 CHEMBL4462704 IC50 0.5 nM
CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCCOc1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1 CHEMBL4212746 IC50 0.5 nM
O=C(NCCCCOc1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1)[C@H]1C[C@@H]2C=C[C@H]1C2 CHEMBL4552017 IC50 0.5 nM
CC1=C(c2cccnc2)[C@H](c2ccc(OCCN3CC(CF)C3)cc2)Oc2ccc(O)cc21 CHEMBL4552853 IC50 0.5 nM
CCC1=C(c2cccc(O)c2)[C@H](c2ccc(OCCN3CC(CF)C3)cc2)Oc2ccc(O)cc21 CHEMBL4470926 IC50 0.5 nM
Oc1cccc(C2=Cc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CC(CF)C3)cc2)c1 CHEMBL4468700 IC50 0.5 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(-c3ccc(C(=O)O)cn3)cc2F)N1CC(C)(C)F CHEMBL5089113 EC50 0.5 nM
CC1(C)Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(NC3CN(CCCF)C3)cn2)N1CC(F)(F)F CHEMBL4752903 pIC50 0.5012 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(OCCN3CC(CF)C3)cn2)N1CC(F)F CHEMBL4763079 pIC50 0.5012 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(NC3CN(CCCF)C3)cn2)N1CC(F)(F)CO CHEMBL4790076 pIC50 0.5012 nM
COc1cc(OCCN2CC(CF)C2)ccc1[C@@H]1c2ccc3[nH]ncc3c2C[C@@H](C)N1CC(C)C CHEMBL4780994 pIC50 0.5012 nM
FCCCN1CC(Nc2ccc([C@@H]3c4ccc5[nH]ncc5c4C[C@@H](C(F)F)N3CC(F)F)nc2)C1 CHEMBL4780699 pIC50 0.5012 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCNCCCF)cc2F)N1CC1(F)COC1 CHEMBL5425697 pIC50 0.5012 nM
Oc1ccc([C@@H]2Sc3c(Cl)cc(O)cc3O[C@@H]2c2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL94116 IC50 0.51 nM
CC/C(=C\c1ccc(O)cc1)c1ccc(O)cc1 CHEMBL573635 EC50 0.52 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OC3CN(CC4(CF)CC4)C3)cc2F)N1CC(C)(C)F CHEMBL4638997 IC50 0.52 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(N3CC(C(=O)O)C3)cc2F)N1CC(C)(C)F CHEMBL5087411 EC50 0.53 nM
COc1cc(C(=O)O)ccc1-c1cc(F)c([C@@H]2c3[nH]c4ccccc4c3C[C@@H](C)N2CC(C)(C)F)c(F)c1 CHEMBL5082229 EC50 0.54 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OC3CN(C[C@H]4C[C@@H]4F)C3)cc2F)N1CC(C)(C)F CHEMBL4634404 IC50 0.55 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(N3CC(C#N)C3)cc2F)N1CC(C)(C)F CHEMBL5076568 EC50 0.55 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OC3CN(C[C@H]4C[C@H]4F)C3)cc2F)N1CC(C)(C)F CHEMBL4640074 IC50 0.56 nM
CN(C)C(=O)c1ccc(-c2ccc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL244001 Ki 0.57 nM
NCCNC(=O)/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1 CHEMBL4073395 Ki 0.57 nM
O/N=C/c1c(O)ccc(-c2ccc(O)cc2)c1Cl CHEMBL1782957 EC50 0.58 nM
CC1=C(c2ccc(F)cc2)[C@H](c2ccc(OCCN3CC(CF)C3)cc2)Oc2cc(F)c(O)cc21 CHEMBL4462970 IC50 0.58 nM
COc1cc(-c2cc(Cl)c([C@@H]3c4[nH]c5ccccc5c4C[C@@H](C)N3CC(C)(C)F)c(Cl)c2)ccc1C(=O)O CHEMBL5088029 EC50 0.58 nM
CC1(c2ccc(OCCN3CCCC3)cc2)c2ccc(O)cc2CCN1c1cccc(O)c1 CHEMBL328388 pIC50(uM) 0.5998 nM
Oc1cccc(C2CCc3cc(O)ccc3N2Cc2ccc(OCCN3CCCCC3)cc2)c1 CHEMBL58688 Ki 0.6 nM
Oc1ccc(C2CCc3cc(O)ccc3N2Cc2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL56198 Ki 0.6 nM
CC1=CC[C@]2(O)C[C@H]1[C@H](c1ccc(O)c(F)c1)OC2(C)C CHEMBL181191 EC50 0.6 nM
Oc1ccc2c(c1)CS[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 CHEMBL183333 IC50 0.6 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3C4CCCC3CC4)cc2)cc1 CHEMBL184367 IC50 0.6 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3C4CCCC3CCC4)cc2)cc1 CHEMBL184360 IC50 0.6 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CC4CC5CC(C4)CC3C5)cc2)cc1 CHEMBL184371 IC50 0.6 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CC[C@H]4C[C@H]43)cc2)cc1 CHEMBL184421 IC50 0.6 nM
C[C@@H]1CCN(CCOc2ccc(C(=O)c3c(-c4ccc(O)cc4)sc4cc(O)ccc34)cc2)C1 CHEMBL372337 IC50 0.6 nM
Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12 CHEMBL46740 IC50 0.6 nM
C[C@@H](COc1ccc([C@@H]2c3ccc(O)cc3CC[C@@H]2c2ccccc2)cc1)N1CCCC1 CHEMBL197495 IC50 0.6 nM
C[C@H]1CCN(CCOc2ccc(C(=O)c3c(-c4ccc(O)cc4)sc4cc(O)ccc34)cc2)C1 CHEMBL2024376 IC50 0.6 nM
CC1(c2ccc(/C=C/C(=O)O)cc2)c2ccc(O)cc2CCN1c1ccc(C2CCC2)cc1 CHEMBL4072611 IC50 0.6 nM
CC1(c2ccc(/C=C/C(=O)O)cc2)c2ccc(O)cc2CCN1c1ccc(CC2CC2)cc1 CHEMBL4078937 IC50 0.6 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCOc2cc(F)c([C@@H]3c4[nH]c5ccccc5c4C[C@@H](C)N3CC(C)(C)F)c(F)c2)C(C)(C)C)cc1 CHEMBL4577622 IC50 0.6 nM
CCCN1CC[C@H](Oc2ccc(C3=C(c4ccc(O)cc4)CCc4ccc(O)cc43)cc2)C1 CHEMBL4463411 EC50 0.6 nM
COc1ccc(/C(=C(\c2ccc(/C=C/C(=O)O)cc2)c2ccc(N3CCOCC3)cc2)C2CCC2)c(Cl)c1 CHEMBL4448909 EC50 0.6 nM
CCC(=C(c1ccc(OCCN2CCCC2)cc1)c1ccc(OCCN2CCCC2)cc1)c1ccccc1 CHEMBL392916 IC50 0.6 nM
COc1cc(Oc2c(-c3ccc(F)cc3C(C)(F)F)sc3c2ccc2[nH]ncc23)ccc1NC1CN(CCCF)C1 CHEMBL5173113 IC50 0.6 nM
Oc1ccc2c(c1)O[C@@H](c1ccc(OCCN3CCCCC3)cc1)C1=C2COc2cc(O)ccc21 CHEMBL207324 IC50 0.61 nM
Oc1ccc2c(c1)OC(c1ccc(OCCN3CC(CF)C3)cc1)C1=C2CCOc2ccc(O)cc21 CHEMBL4464146 IC50 0.61 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(N3CC(OCCF)C3)cc2F)N1CC(C)(C)F CHEMBL5078457 EC50 0.61 nM
COc1cc(-c2ccc(C(=O)O)cc2)cc(F)c1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1CC(C)(C)F CHEMBL5088560 EC50 0.61 nM
CS(=O)(=O)c1ccc(-c2sc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL389907 Ki 0.63 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1[C@H](C)C(=O)O CHEMBL4864628 DC50 0.63 nM
CC(C)(F)CN1[C@@H]2C=CC[C@@]1(c1c(F)cc(/C=C/C(=O)O)cc1F)c1[nH]c3ccccc3c1C2 CHEMBL4587197 pIC50 0.631 nM
CC(C)CN1[C@H](c2ccc(/C=C/C(=O)O)cc2)c2ccc3[nH]ncc3c2C[C@H]1C CHEMBL4541930 pIC50 0.631 nM
COc1cc(/C=C/C(=O)O)ccc1[C@@H]1c2ccc3[nH]ncc3c2C[C@@H](C)N1CC(C)(C)F CHEMBL4536148 pIC50 0.631 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(NCCNCCCF)cn2)N1CC(F)(F)F CHEMBL4744329 pIC50 0.631 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(NC3CN(CCCF)C3)cn2)N1CC1(F)CC1 CHEMBL4759607 pIC50 0.631 nM
Cc1c(OCCNCCCF)ccc(F)c1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1C[C@H](C)C(=O)O CHEMBL5404810 pIC50 0.631 nM
Oc1ccc2c3c(cnc2c1)-c1ccc(C(F)(F)F)cc1O[C@@H]3c1ccc(OCCN2CC(CF)C2)cc1 CHEMBL5095183 Ki 0.64 nM
Cc1cccc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(/C=C/C(=O)O)cc1 CHEMBL4094499 EC50 0.65 nM
Cc1cc(F)ccc1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(/C=C/C(=O)O)cc1 CHEMBL4098867 Ki 0.65 nM
O=C(/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1)NCCCCCO CHEMBL4100247 Ki 0.65 nM
C[C@@H]1c2ccc(O)cc2O[C@@H](c2ccc(OCCN3CCCCC3)cc2)[C@H]1c1ccc(O)cc1 CHEMBL362428 IC50 0.66 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(-c3ccc(C(N)=O)cc3)cc2F)N1CC(C)(C)F CHEMBL5088627 EC50 0.66 nM
Nc1ccc(C2=C(c3ccc(O)cc3)Cc3cc(O)ccc32)cc1 CHEMBL380565 Ki 0.67 nM
CCCn1c(-c2ccc(O)cc2F)cc(-c2ccc(O)cc2)c1-c1ccc(O)cc1 CHEMBL2179251 EC50 0.67 nM
CCCCCCCCCCNCCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1 CHEMBL3806167 IC50 0.68 nM
C[C@H](CF)CN1[C@H](c2c(F)cc(/C=C/C(=O)O)cc2F)c2ccc(O)cc2CC1(C)C CHEMBL3774510 IC50 0.69 nM
CC1(c2ccc(OCCN3CCCCC3)cc2)c2ccc(O)cc2CCN1c1cccc(O)c1 CHEMBL100617 pIC50(uM) 0.6998 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2CCCN2CCCCC2)cc1 CHEMBL122208 IC50 0.7 nM
C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O CHEMBL1405 EC50 0.7 nM
C[C@@H]1c2c(ccc(O)c2F)O[C@@H](c2ccc(OC[C@H](C)N3CCC[C@H]3C)cc2)[C@H]1c1ccc(O)cc1 CHEMBL181248 IC50 0.7 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CC4CC4C3)cc2)cc1 CHEMBL184202 IC50 0.7 nM
C[C@@H]1CCCN1CCOc1ccc([C@@H]2Oc3ccc(O)cc3S[C@@H]2c2ccc(O)cc2)cc1 CHEMBL183489 IC50 0.7 nM
C[C@@H]1CN(CCOc2ccc([C@@H]3Oc4ccc(O)cc4S[C@@H]3c3ccc(O)cc3)cc2)C[C@@H]1C CHEMBL367574 IC50 0.7 nM
CC[C@H](COc1ccc([C@@H]2Oc3ccc(O)cc3S[C@@H]2c2ccc(O)cc2)cc1)N1CCCC1 CHEMBL369545 IC50 0.7 nM
CC(C)[C@@H](COc1ccc([C@@H]2Oc3ccc(O)cc3S[C@@H]2c2ccc(O)cc2)cc1)N1CCCC1 CHEMBL183263 IC50 0.7 nM
CC(C)(COc1ccc([C@@H]2Oc3ccc(O)cc3S[C@@H]2c2ccc(O)cc2)cc1)N1CCCC1 CHEMBL179852 IC50 0.7 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CC4CC3CO4)cc2)cc1 CHEMBL434525 IC50 0.7 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1ccc2[nH]ncc2c1)c1ccccc1Cl CHEMBL3581682 EC50 0.7 nM
Oc1cccc(C2=C(c3ccc(O[C@H]4CCN(CCCF)C4)cc3)c3ccc(O)cc3CCC2)c1 CHEMBL4162177 IC50 0.7 nM
CC1=C(c2cccc(C#N)c2)C(c2ccc(OC[C@H](C)N3CC[C@@H](C)C3)cc2)Oc2ccc(O)cc21 CHEMBL4175025 IC50 0.7 nM
O=C(O)c1ccc2c(c1)CCCC(c1ccc(OC(F)(F)F)cc1)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4547379 EC50 0.7 nM
Oc1ccc2c(c1)CCCC(c1ccccc1Cl)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4534892 EC50 0.7 nM
Oc1ccc(C2=C(c3ccc(O[C@H]4CCN(CCCF)C4)cc3)c3ccc(O)cc3CCC2)cc1 CHEMBL4440422 EC50 0.7 nM
O=C(O)/C=C/c1ccc(/C(=C(\c2ccc(F)cc2Cl)C2CCC2)c2ccc3scnc3c2)cc1 CHEMBL4472714 EC50 0.7 nM
N#Cc1ccc(/C(=C(\c2ccc(/C=C/C(=O)O)cc2)c2ccc(-c3cn[nH]c3)cc2)C2CCC2)c(Cl)c1 CHEMBL4559957 EC50 0.7 nM
COc1cc(N2CCN(CCC3CCN(c4ccc([C@@H]5c6ccc(O)cc6CC[C@@H]5c5ccccc5)cc4F)CC3)CC2)cc2c1C(=O)N(C1CCC(=O)NC1=O)C2 CHEMBL4533684 IC50 0.7 nM
COc1cc(N2CCN(CC(=O)C3CC(Oc4ccc([C@@H]5c6ccc(O)cc6CC[C@@H]5c5ccccc5)cc4)C3)CC2)cc2c1C(=O)N(C1CCC(=O)NC1=O)C2 CHEMBL4469271 IC50 0.7 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(-c3cccc(C(=O)O)c3)cc2F)N1CC(C)(C)F CHEMBL5076325 EC50 0.7 nM
CC(F)(F)c1cc(Cl)ccc1-c1sc2c(ccc3[nH]ncc32)c1Oc1ccc(O[C@@H]2CCN(CCCF)C2)cc1 CHEMBL5174315 EC50 0.7 nM
COc1cc(Oc2c(-c3ccc(F)cc3C(C)(C)F)sc3c2ccc2[nH]ncc23)ccc1NC1CN(CCCF)C1 CHEMBL5205039 IC50 0.7 nM
CCCCN(C)C(=O)/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1 CHEMBL4081283 Ki 0.71 nM
CCCCNC(=O)/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1 CHEMBL4098470 Ki 0.71 nM
O=C(/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1)OCCCO CHEMBL4098232 Ki 0.71 nM
CC(C)S(=O)(=O)c1ccc(-c2ccc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL243791 Ki 0.73 nM
CCCCCNC(=O)/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1 CHEMBL4081969 Ki 0.74 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1ccc(Cl)cc1C(F)(F)F CHEMBL4779838 IC50 0.76 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(/C=C/C(=O)O)cc2F)N1CC(F)(F)CO CHEMBL4864337 DC50 0.78 nM
COc1cc(N2CCN(CCCCCOc3ccc([C@@H]4c5ccc(O)cc5CC[C@@H]4c4ccccc4)cc3)CC2)cc2c1C(=O)N(C1CCC(=O)NC1=O)C2 CHEMBL4472956 IC50 0.79 nM
CC(C)(F)CN1[C@@H]2CCC[C@@]1(c1c(F)cc(/C=C/C(=O)O)cc1F)c1[nH]c3ccccc3c1C2 CHEMBL4452972 pIC50 0.7943 nM
CC(C)CN1[C@H](c2c(F)cc(/C=C/C(=O)O)cc2F)c2ccc3[nH]ncc3c2C[C@H]1C CHEMBL4462367 pIC50 0.7943 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(N(C)[C@H]3CCN(CCCF)C3)cn2)N1CC(F)(F)F CHEMBL4797178 pIC50 0.7943 nM
CC1(C)Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(NC3CN(CCCF)C3)cn2)N1CC(F)F CHEMBL4797729 pIC50 0.7943 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2ccc(OCCNCCCF)cc2)N1CC1(F)COC1 CHEMBL5425859 pIC50 0.7943 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2cccc(OCCNCCCF)c2F)N1CC(F)(F)F CHEMBL5427839 pIC50 0.7943 nM
Cc1c(OCCNCCCF)ccc(F)c1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1C[C@@H](C)C(=O)O CHEMBL5432663 pIC50 0.7943 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL304552 IC50 0.8 nM
CC1CCN(CCOc2ccc([C@@H]3Oc4ccc(O)cc4S[C@@H]3c3cccc(O)c3)cc2)CC1 CHEMBL92635 IC50 0.8 nM
Oc1ccc([C@@H]2Sc3c(ccc(O)c3F)O[C@@H]2c2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL328716 IC50 0.8 nM
C[C@H]1CCN(CCOc2ccc([C@@H]3Oc4ccc(O)c(F)c4[C@@H](C)[C@@H]3c3ccc(O)cc3)cc2)C1 CHEMBL181404 IC50 0.8 nM
C[C@@H]1CCN(CCOc2ccc([C@@H]3Oc4ccc(O)c(F)c4[C@@H](C)[C@@H]3c3ccc(O)cc3)cc2)C1 CHEMBL361005 IC50 0.8 nM
C[C@@H]1c2c(ccc(O)c2F)O[C@@H](c2ccc(OCCN3CCCCC3)cc2)[C@H]1c1ccc(O)cc1 CHEMBL180146 IC50 0.8 nM
C[C@H]1CCCN1CCOc1ccc([C@@H]2Oc3ccc(O)cc3S[C@@H]2c2ccc(O)cc2)cc1 CHEMBL183344 IC50 0.8 nM
CC[C@@H](CN1CCCC1)Oc1ccc([C@@H]2Oc3ccc(O)cc3S[C@@H]2c2ccc(O)cc2)cc1 CHEMBL183092 IC50 0.8 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CC4CCC4C3)cc2)cc1 CHEMBL184598 IC50 0.8 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1ccc2[nH]ncc2c1)c1ccccc1C CHEMBL3581688 EC50 0.8 nM
Oc1ccc(Oc2sc3cc(O)ccc3c2-c2ccc(F)cc2)cc1 CHEMBL3763743 EC50 0.8 nM
C/C(=C(/c1ccc(O)cc1)c1ccc(OCCN2CCCC2)cc1)c1ccccc1 CHEMBL3775016 IC50 0.8 nM
CC(C)Cc1ccc(N2CCc3cc(O)ccc3C2(C)c2ccc(/C=C/C(=O)O)cc2)cc1 CHEMBL4076352 IC50 0.8 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOc2cc(F)c([C@@H]3c4[nH]c5ccccc5c4C[C@@H](C)N3CC(C)(C)F)c(F)c2)C(C)(C)C)cc1 CHEMBL4476831 IC50 0.8 nM
O=C(O)/C=C/c1ccc(/C(=C(\c2ccc(F)cc2Cl)C2CCC2)c2ccc(-c3cncs3)cc2)cc1 CHEMBL4562048 EC50 0.8 nM
N#Cc1ccc(/C(=C(\c2ccc(/C=C/C(=O)O)cc2)c2ccc3scnc3c2)C2CCC2)c(Cl)c1 CHEMBL4563585 EC50 0.8 nM
COc1ccc(/C(=C(\c2ccc(/C=C/C(=O)O)cc2)c2ccc(-c3cncs3)cc2)C2CCC2)c(Cl)c1 CHEMBL4442838 EC50 0.8 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OCCN3CC[C@@H](C#N)C3)cc2)Oc2ccc(O)cc21 CHEMBL4450664 IC50 0.8 nM
C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@]2(O)c1ccc2c(c1)COC2 CHEMBL1097377 EC50 0.8 nM
COc1cc(Oc2c(-c3ccc(F)cc3C(C)(C)F)sc3c2ccc2[nH]ncc23)ccc1OC1CN(CCCF)C1 CHEMBL5171948 IC50 0.8 nM
COc1cc(N2CCN(C3CC4CC(Oc5ccc([C@@H]6c7ccc(O)cc7CC[C@@H]6c6ccc(F)cc6)cc5)CC4C3)CC2)cc2c1C(=O)N(C1CCC(=O)NC1=O)C2 CHEMBL4466148 IC50 0.82 nM
CCCn1c(-c2ccc(O)cc2)cc(-c2ccc(O)cc2F)c1-c1ccc(O)cc1 CHEMBL2179256 EC50 0.84 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(-c3ccc(C(=O)O)cc3)cc2Cl)N1CC(C)(C)F CHEMBL5093417 EC50 0.85 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2ccc(/C=C/C(=O)O)cc2)N1CC(C)(C)F CHEMBL3623003 pIC50 0.8511 nM
O=C(c1ccc(N2CCN(C(=O)c3ccccc3)CC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12 CHEMBL360498 IC50 0.86 nM
CC(C)(F)CN1[C@H](CF)Cc2c([nH]c3ccccc23)[C@H]1c1c(F)cc(/C=C/C(=O)O)cc1F CHEMBL5082554 EC50 0.86 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1ccccc1C(F)(F)F CHEMBL4752200 IC50 0.87 nM
C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@]2(O)c1cn(-c2ccc(O)cc2)nn1 CHEMBL4761096 EC50 0.87 nM
Oc1ccc(C2CCc3cc(O)ccc3N2c2ccc(OCCN3CCCC3)cc2)cc1 CHEMBL56390 Ki 0.9 nM
Oc1cccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CCCC3)cc2)c1 CHEMBL327320 IC50 0.9 nM
C[C@@H]1c2c(ccc(O)c2F)O[C@@H](c2ccc(OCCN3CCCC3)cc2)[C@H]1c1ccc(O)cc1 CHEMBL181369 IC50 0.9 nM
C[C@@H]1CCN([C@@H](C)COc2ccc([C@@H]3Oc4ccc(O)c(F)c4[C@@H](C)[C@@H]3c3ccc(O)cc3)cc2)C1 CHEMBL180995 IC50 0.9 nM
CC[C@@H]1CCN(CCOc2ccc([C@@H]3Oc4ccc(O)cc4S[C@@H]3c3ccc(O)cc3)cc2)C1 CHEMBL183388 IC50 0.9 nM
CC1(C)CCCN1CCOc1ccc([C@@H]2Oc3ccc(O)cc3S[C@@H]2c2ccc(O)cc2)cc1 CHEMBL183371 IC50 0.9 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3C4CCC3CC4)cc2)cc1 CHEMBL368688 IC50 0.9 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1ccc2[nH]ncc2c1)c1ccc(C#N)cc1Cl CHEMBL3581692 EC50 0.9 nM
CC(C)c1ccc(N2CCc3cc(O)ccc3C2(C)c2ccc(/C=C/C(=O)O)cc2)cc1 CHEMBL4101697 IC50 0.9 nM
CC1=C(c2cccc(O)c2)C(c2ccc(OC[C@H](C)N3CCC3)cc2)Oc2ccc(O)cc21 CHEMBL4159755 IC50 0.9 nM
Oc1ccc2c(c1)CCCC(c1ccc(Cl)cc1Cl)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4471337 EC50 0.9 nM
CC(F)(F)c1cc(F)ccc1-c1sc2c(ccc3[nH]ncc32)c1Oc1ccc(OCCN2CC(CF)C2)cc1 CHEMBL5207484 EC50 0.9 nM
COc1cc(Oc2c(-c3ccc(F)cc3CC(F)(F)F)sc3c2ccc2[nH]ncc23)ccc1OC1CN(CCCF)C1 CHEMBL5205357 IC50 0.9 nM
Cc1ccccc1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(OCCN2CC(CF)C2)cc1 CHEMBL4532671 pIC50 0.955 nM
O=C(O)/C=C/c1ccc(C2c3ccc(O)cc3CCN2c2ccc(OC(F)(F)F)cc2)cc1 CHEMBL3774777 IC50 0.96 nM
O=C(c1ccc(N2CCN(Cc3ccccc3)CC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12 CHEMBL2113001 IC50 0.97 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1ccc(C(F)(F)F)cc1Cl CHEMBL4763244 IC50 0.98 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(N3CC4(CC(C(=O)O)C4)C3)cc2F)N1CC(C)(C)F CHEMBL5081424 EC50 0.98 nM
Cn1cc(NC(=O)c2cc(NC(=O)CCS(C)(=O)=O)cn2C)cc1C(=O)NCC(=O)NCCCCCC[C@@H]1Cc2cc(O)ccc2[C@H]2CC[C@]3(C)[C@@H](O)CC[C@H]3[C@H]12 CHEMBL5071091 IC50 0.99 nM
Oc1ccc(C2=Cc3cc(O)ccc3C23Cc2ccc(OCCN4CCCCC4)cc2C3)cc1 CHEMBL267385 IC50 1.0 nM
CN1CCN(c2ccc([C@@H]3Oc4ccc(O)cc4S[C@@H]3c3ccc(O)cc3)cc2)CC1 CHEMBL121978 IC50 1.0 nM
CCN1CCN(c2ccc([C@@H]3Oc4ccc(O)cc4S[C@@H]3c3ccc(O)cc3)cc2)CC1 CHEMBL121720 IC50 1.0 nM
Oc1ccc([C@@H]2Sc3c(ccc(O)c3Cl)O[C@@H]2c2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL92660 IC50 1.0 nM
Oc1ccc([C@H]2Sc3c(ccc(O)c3F)O[C@H]2c2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL329892 IC50 1.0 nM
CC1=CC[C@]2(O)C[C@H]1[C@H](c1ccc(O)cc1Cl)OC2(C)C CHEMBL359512 EC50 1.0 nM
C[C@H]1CCN(CCOc2ccc([C@@H]3Oc4ccc(O)cc4S[C@@H]3c3ccc(O)cc3)cc2)C1 CHEMBL183049 IC50 1.0 nM
CC1(C)CCN(CCOc2ccc([C@@H]3Oc4ccc(O)cc4S[C@@H]3c3ccc(O)cc3)cc2)C1 CHEMBL182887 IC50 1.0 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3C[C@H]4CCCC[C@H]4C3)cc2)cc1 CHEMBL185231 IC50 1.0 nM
CN(C)CCOc1ccc(/C(=C(/CCN=[N+]=[N-])c2ccccc2)c2ccc(O)cc2)cc1 CHEMBL203472 IC50 1.0 nM
C[C@H](CCc1ccc(O)cc1)NC(=O)Cc1c(-c2ccccc2)[nH]c2ccccc12 CHEMBL391910 IC50 1.0 nM
CC(CCc1ccc(O)cc1)NC(=O)Cc1c(-c2ccccc2)[nH]c2ccccc12 CHEMBL241301 IC50 1.0 nM
C#CCN(c1ccc(C(=O)N[C@@H](CCC(=O)N[C@H](CCC(=O)O)C(=O)O)C(=O)O)cc1)C1CCc2cc3nc(CO)[nH]c(=O)c3cc21 CHEMBL1253498 IC50 1.0 nM
Oc1ccc(C(=Nc2ccccc2Cl)c2ccc(O)cc2)cc1 CHEMBL3234617 EC50 1.0 nM
Oc1ccc(C(=Nc2ccc(Br)cc2)c2ccc(O)cc2)cc1 CHEMBL3234622 EC50 1.0 nM
Cc1cc(OC(F)(F)F)ccc1-c1c(Cc2ccc(/C=C/C(=O)O)cc2)c2ccc(O)cc2oc1=O CHEMBL3427399 IC50 1.0 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1ccc2[nH]ncc2c1)c1ccc(C#N)cc1C CHEMBL3581691 EC50 1.0 nM
COC(=O)CCCCCCC(=O)Nc1cccc(OS(=O)(=O)C2CC3OC2C(c2ccc(O)cc2)=C3c2ccc(O)cc2)c1 CHEMBL3589348 EC50 1.0 nM
O=C(c1sc2cc(O)ccc2c1-c1ccc(F)cc1)C1CCCCC1 CHEMBL3764437 EC50 1.0 nM
Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CC4CCC3C4)cc2)c2ccc(O)cc12 CHEMBL3657181 IC50 1.0 nM
CCC(=C(c1ccc(O)cc1)c1ccc(/C=C/C(=O)O)cc1)c1ccccc1 CHEMBL1091535 Ki 1.0 nM
Cn1nnnc1/C=C/c1ccc(Oc2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1 CHEMBL4059624 IC50 1.0 nM
O=C(/C=C/c1ccc(Oc2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1)NCCC(F)(F)F CHEMBL4098433 IC50 1.0 nM
CCc1ccccc1-c1sc2cc(O)ccc2c1Oc1ccc(/C=C/C(=O)O)cc1 CHEMBL4063737 IC50 1.0 nM
CC(C)(C)c1ccccc1-c1sc2cc(O)ccc2c1Oc1ccc(/C=C/C(=O)O)cc1 CHEMBL4059818 IC50 1.0 nM
O=C(O)/C=C/c1ccc(Oc2c(-c3ccccc3C(F)(F)F)sc3cc(O)ccc23)cc1 CHEMBL4076693 IC50 1.0 nM
O=C(O)/C=C/c1ccc(Oc2c(-c3ccc(F)cc3C(F)(F)F)sc3cc(O)ccc23)cc1 CHEMBL4069567 IC50 1.0 nM
O=C(O)c1ccc2c(c1)CCCC(c1ccccc1Cl)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4516726 EC50 1.0 nM
CCN1CC[C@H](Oc2ccc(C3=C(c4ccc(O)cc4)CCc4ccc(O)cc43)cc2)C1 CHEMBL4563508 EC50 1.0 nM
O=C(O)/C=C/c1ccc(/C(=C(\c2ccc(C(F)(F)F)cc2Cl)C2CCC2)c2ccc3scnc3c2)cc1 CHEMBL4577104 EC50 1.0 nM
COc1cc(/C=C/C(=O)O)ccc1[C@@H]1c2ccc3[nH]ncc3c2C[C@@H](C)N1CC(C)(F)F CHEMBL4517931 pIC50 1.0 nM
CC1=C(c2ccc(F)cc2)[C@H](c2ccc(OCCN3CC(CF)C3)cc2)Oc2cc(Cl)c(O)cc21 CHEMBL4586333 IC50 1.0 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@](C)(c2ccc(NC3CN(CCCF)C3)cn2)N1CC(F)F CHEMBL4787725 pIC50 1.0 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(NCCNCCCF)cn2)N1CC1(F)CC1 CHEMBL4779640 pIC50 1.0 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2ncc(/C=C/C(=O)O)cc2F)N1CC(C)(C)F CHEMBL5083844 EC50 1.0 nM
CC(F)(F)c1cc(Cl)ccc1-c1sc2c(ccc3[nH]ncc32)c1Oc1ccc(N[C@@H]2CCN(CCCF)C2)cc1 CHEMBL5177756 EC50 1.0 nM
CC(F)(F)c1cc(Cl)ccc1-c1sc2cc(C(=O)O)ccc2c1Oc1ccc(O[C@@H]2CCN(CCCF)C2)cc1 CHEMBL5173602 EC50 1.0 nM
CC(F)(F)c1cc(-c2sc3cc(O)ccc3c2Oc2ccc(/C=C/C(=O)O)cc2)ccc1F CHEMBL5191161 EC50 1.0 nM
CC(C)(F)c1cc(F)ccc1-c1sc2c(ccc3[nH]ncc32)c1Oc1ccc(NC2CN(CCCF)C2)cc1 CHEMBL5190953 IC50 1.0 nM
CC(F)(F)c1cc(F)ccc1-c1sc2c(ccc3[nH]ncc32)c1Oc1ccc(OC2CN(CCCF)C2)c(F)c1 CHEMBL5169445 IC50 1.0 nM
O=C1CC[C@H](N2Cc3cc(N4CCN(CC5CCN(c6ccc([C@@H]7c8ccc(O)cc8CC[C@@H]7c7ccccc7)cc6)CC5)CC4)ccc3C2=O)C(=O)N1 CHEMBL5095210 EC50 1.0 nM
Cc1c(OCCN2CC(CF)C2)ccc(F)c1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1C[C@H](C)C(=O)O CHEMBL5424786 pIC50 1.0 nM
O=C(c1ccccc1)c1sc2cc(O)ccc2c1Oc1ccc(OCCN2CC(CF)C2)cc1 CHEMBL4515212 pIC50 1.023 nM
Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(OC2CN(CCCF)C2)cc1 CHEMBL4533964 pIC50 1.023 nM
O=S1(=O)CC=C(c2ccc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)CC1 CHEMBL244207 Ki 1.03 nM
O=C(c1ccc(N2CCN(C3CCCC3)CC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12 CHEMBL366928 IC50 1.08 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(Nc3cnc(C(=O)O)s3)cc2F)N1CC(C)(C)F CHEMBL5080574 EC50 1.08 nM
CS(=O)(=O)C1CC=C(c2ccc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)CC1 CHEMBL390448 Ki 1.09 nM
Oc1ccc(C2CCc3cc(O)ccc3N2Cc2ccc(OCCN3CCCC3)cc2)cc1 CHEMBL56306 Ki 1.1 nM
O/N=C/c1ccc(-c2ccccc2)c(-c2ccccc2)c1O CHEMBL128654 Ki 1.1 nM
CC1=CC[C@]2(O)C[C@H]1[C@H](c1ccc(O)cc1F)OC2(C)C CHEMBL369337 EC50 1.1 nM
CC[C@H]1CCN(CCOc2ccc([C@@H]3Oc4ccc(O)cc4S[C@@H]3c3ccc(O)cc3)cc2)C1 CHEMBL2113027 IC50 1.1 nM
C[C@]12C[C@H](c3ccc(OCCOCCOCCn4cc(CNC5=CC(=O)c6ccccc6C5=O)nn4)cc3)[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@H]2O CHEMBL2036560 Ki 1.1 nM
Cc1ccccc1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(/C=C/C(=O)O)cc1 CHEMBL4092208 EC50 1.1 nM
CCCNC(=O)/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1 CHEMBL4071436 Ki 1.1 nM
O=C(O)/C=C/c1ccc(/C(=C(\c2ccc(F)cc2Cl)C2CCC2)c2ccc(-c3cn[nH]c3)cc2)cc1 CHEMBL4531707 EC50 1.1 nM
N#Cc1cc(Cl)ccc1/C(=C(\c1ccc(/C=C/C(=O)O)cc1)c1ccc(-c2cn[nH]c2)cc1)C1CCC1 CHEMBL4455108 EC50 1.1 nM
O=C(O)/C=C/c1ccc(/C(=C(\c2ncc(C(F)(F)F)cc2Cl)C2CCC2)c2ccc3scnc3c2)cc1 CHEMBL4455921 EC50 1.1 nM
CC1=C(c2ccccc2)[C@H](c2ccc(OCCN3CC(CF)C3)cc2)Oc2ccccc21 CHEMBL4543969 IC50 1.1 nM
CC(F)(F)c1cc(Cl)ccc1-c1sc2c(ccc3[nH]ncc32)c1Oc1ccc(OC2CN(CCCF)C2)cc1 CHEMBL5185539 EC50 1.1 nM
CC(F)(F)c1cc(F)ccc1-c1sc2c(ccc3[nH]ncc32)c1Oc1ccc(NC2CN(CCCF)C2)c(F)c1 CHEMBL5184413 IC50 1.1 nM
COc1cc(Oc2c(-c3ccc(F)cc3CC(F)(F)F)sc3c2ccc2[nH]ncc23)ccc1NC1CN(CCCF)C1 CHEMBL5191391 IC50 1.1 nM
Cn1cc(NC(=O)c2cc(NC(=O)CCS(C)(=O)=O)cn2C)cc1C(=O)NCCCC(=O)NCCCCCC[C@@H]1Cc2cc(O)ccc2[C@H]2CC[C@]3(C)[C@@H](O)CC[C@H]3[C@H]12 CHEMBL1818254 IC50 1.11 nM
CCC(=C(c1ccc(/C=C/C(=O)O)cc1)c1ccc(B(O)O)cc1)c1ccccc1 CHEMBL3885342 IC50 1.14 nM
Cc1c(O)ccc2c1O[C@H](c1ccc(OCCN3CCCCC3)cc1)[C@H](c1ccc(O)cc1)S2 CHEMBL329849 IC50 1.2 nM
Oc1cccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCNC3CCCCCC3)cc2)c1 CHEMBL94225 IC50 1.2 nM
CC[C@H](CN1CCCC1)Oc1ccc([C@@H]2Oc3ccc(O)cc3S[C@@H]2c2ccc(O)cc2)cc1 CHEMBL183086 IC50 1.2 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CCC4(CCCC4)CC3)cc2)cc1 CHEMBL184974 IC50 1.2 nM
Oc1ccc2c(c1)O[C@H](c1ccc(OCCN3CCCC3)cc1)C1=C2CCOc2cc(O)ccc21 CHEMBL1086775 IC50 1.2 nM
Oc1ccc2c(c1)O[C@H](c1ccc(OCCN3CCSCC3)cc1)C1=C2CCOc2cc(O)ccc21 CHEMBL1083178 IC50 1.2 nM
COC[C@H](C)CN1[C@H](c2c(F)cc(/C=C/C(=O)O)cc2F)c2ccc(O)cc2C[C@H]1C CHEMBL3774737 IC50 1.2 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2cnc(N3CCC(CCN4CCC5(CC4)CCN(c4ccc6c(c4)CN(C4CCC(=O)NC4=O)C6=O)CC5)CC3)nc2)N1CC(C)(C)F CHEMBL4760508 IC50 1.2 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OC3CN(CCCF)C3)cc2F)N1C(=O)C1(F)CCC1 CHEMBL4858240 DC50 1.2 nM
CC(F)(F)c1cc(F)ccc1-c1sc2cc(B(O)O)ccc2c1Oc1ccc(OCCN2CC(CF)C2)cc1 CHEMBL5202286 EC50 1.2 nM
CC(F)(F)c1cc(Cl)ccc1-c1sc2c(ccc3[nH]ncc32)c1Oc1ccc(NC2CN(CCCF)C2)cc1 CHEMBL5197035 EC50 1.2 nM
CC(C)(F)c1cc(F)ccc1-c1sc2c(ccc3[nH]ncc32)c1Oc1ccc(OC2CN(CCCF)C2)c(F)c1 CHEMBL5171955 IC50 1.2 nM
CCS(=O)(=O)c1ccc(-c2ccc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL243790 Ki 1.22 nM
O=C(c1ccc(F)cc1)c1sc2cc(O)ccc2c1Oc1ccc(OCCN2CC(CF)C2)cc1 CHEMBL4524872 pIC50 1.23 nM
COc1c([C@@H]2c3ccc4[nH]ncc4c3C[C@@H](C)N2CC(C)(F)F)ccc(/C=C/C(=O)O)c1F CHEMBL4518390 pIC50 1.259 nM
Cc1ccc(OCCNCCCF)c(F)c1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1CC(F)(F)F CHEMBL5424726 pIC50 1.259 nM
Cc1c(OCCNCCCF)ccc(F)c1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1CCC(=O)O CHEMBL5436976 pIC50 1.259 nM
CC/C(=C(/c1ccc(O)cc1)c1ccc(/C=C/C(=O)NCCCNC(=O)/C=C/c2ccc(/C(=C(\CC)c3ccccc3)c3ccc(O)cc3)cc2)cc1)c1ccccc1 CHEMBL4758245 IC50 1.28 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(/C=C/C(=O)NO)cc2F)N1CC(C)(C)F CHEMBL5087052 EC50 1.28 nM
CCC(=C(c1ccc(O)cc1)c1ccc(/C=C/C(=O)NCCCCCNC(=O)CCc2nc3cc(O)ccc3[nH]2)cc1)c1ccccc1 CHEMBL5076984 IC50 1.28 nM
Oc1ccc2c(c1)S[C@@H](c1ccccc1O)[C@@H](c1ccc(OCCN3CCCCC3)cc1)O2 CHEMBL91758 IC50 1.3 nM
C[C@H]1CCN(CCOc2ccc([C@@H]3Oc4ccc(O)cc4[C@@H](C)[C@@H]3c3ccc(O)cc3)cc2)C1 CHEMBL433581 IC50 1.3 nM
C[C@@H]1CCN([C@@H](C)COc2ccc([C@@H]3Oc4ccc(O)cc4[C@@H](C)[C@@H]3c3ccc(O)cc3)cc2)C1 CHEMBL368449 IC50 1.3 nM
Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 CHEMBL328190 IC50 1.3 nM
C[C@H](COc1ccc([C@@H]2Oc3ccc(O)cc3S[C@@H]2c2ccc(O)cc2)cc1)N1CCCC1 CHEMBL180792 IC50 1.3 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CC4CCC3CC4)cc2)cc1 CHEMBL361056 IC50 1.3 nM
C[C@@H](COc1ccc([C@@H]2Oc3ccc(O)cc3S[C@@H]2c2ccc(O)cc2)cc1)N1CCCC1 CHEMBL180300 IC50 1.3 nM
C[C@@H]1CCN([C@@H](C)COc2ccc([C@@H]3Oc4ccc(O)cc4S[C@@H]3c3ccc(O)cc3)cc2)C1 CHEMBL182402 IC50 1.3 nM
Cc1cc(F)ccc1-c1c(Cc2ccc(/C=C/C(=O)O)cc2)c2c(F)cc(O)cc2oc1=O CHEMBL3427405 IC50 1.3 nM
C/C(=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1 CHEMBL3774660 IC50 1.3 nM
C[C@H](CF)CN1[C@H](c2ccc(/C=C/C(=O)O)cc2)c2ccc(O)cc2CC1(C)C CHEMBL3775833 IC50 1.3 nM
CC(C)CN1[C@H](c2ccc(/C=C/C(=O)O)cc2)c2ccc(O)cc2C[C@H]1C CHEMBL3775378 IC50 1.3 nM
CCCC(CCC)(c1ccc(O)c(C)c1)c1ccc(O)c(C)c1 CHEMBL2403356 IC50 1.3 nM
CCCC(CCC)(c1ccc(N)c(C)c1)c1ccc(O)c(C)c1 CHEMBL4473971 EC50 1.3 nM
FCCCN1CC(Nc2ccc(Oc3c(-c4ccc(F)cc4CC(F)(F)F)sc4c3ccc3[nH]ncc34)cc2)C1 CHEMBL5180046 IC50 1.3 nM
CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1 CHEMBL954 Ki 1.304 nM
O=C(/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1)NCC(F)(F)F CHEMBL4091563 Ki 1.33 nM
O=C(c1ccc(N2CCN(C(=O)c3cccc(O)c3)CC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12 CHEMBL441499 IC50 1.39 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(C3=CCNCC3)cc2)cc1 CHEMBL334096 IC50 1.4 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(CCCN3CCCCC3)cc2)cc1 CHEMBL124474 IC50 1.4 nM
CN(C)CCOc1ccc([C@@H]2Oc3ccc(O)cc3S[C@@H]2c2cccc(O)c2)cc1 CHEMBL329902 IC50 1.4 nM
C[C@@H]1c2cc(O)ccc2O[C@@H](c2ccc(OC[C@H](C)N3CCCC3)cc2)[C@H]1c1ccc(O)cc1 CHEMBL360315 IC50 1.4 nM
C[C@@H]1c2cc(O)ccc2O[C@@H](c2ccc(OCCN3CCCCC3)cc2)[C@H]1c1ccc(O)cc1 CHEMBL178470 IC50 1.4 nM
CCCCc1ccc(N2CCc3cc(O)ccc3C2(C)c2ccc(/C=C/C(=O)O)cc2)cc1 CHEMBL4065632 IC50 1.4 nM
N#C/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1 CHEMBL4068722 Ki 1.4 nM
CC1=C(c2cccc(S(C)(=O)=O)c2)C(c2ccc(OC[C@H](C)N3CC[C@@H](C)C3)cc2)Oc2ccc(O)cc21 CHEMBL4159900 IC50 1.4 nM
O=C(O)/C=C/c1ccc(/C(=C(\c2ncc(C(F)(F)F)cc2Cl)C2CCC2)c2ccc(-c3cncs3)cc2)cc1 CHEMBL4437503 EC50 1.4 nM
CCC(CC)(c1ccc(O)c(C)c1)c1ccc(O)c(C)c1 CHEMBL2403355 IC50 1.4 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1cc(Cl)ccc1Cl CHEMBL4763298 IC50 1.4 nM
COc1cc(Oc2c(-c3cc(F)c(F)cc3C(C)(F)F)sc3c2ccc2[nH]ncc23)ccc1OC1CN(CCCF)C1 CHEMBL5203346 IC50 1.4 nM
CCC(=C(c1ccc(O)cc1)c1ccc(/C=C/C(=O)NCCCCNC(=O)CCCCCCCn2c(=S)[nH]c3ccccc3c2=O)cc1)c1ccccc1 CHEMBL5086315 IC50 1.41 nM
Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(OCCN2CC(CF)C2)cc1 CHEMBL4543096 pIC50 1.413 nM
CCCN1CCN(c2ccc(C(=O)c3c(-c4ccc(O)cc4)sc4cc(O)ccc34)cc2)CC1 CHEMBL179518 IC50 1.43 nM
Cc1ccc(C(=O)c2sc3cc(O)ccc3c2Oc2ccc(OCCN3CC(CF)C3)cc2)c(C)c1 CHEMBL4483006 pIC50 1.445 nM
CCC(=C(c1ccc(O)cc1)c1ccc(/C=C/C(=O)NCCNC(=O)CCc2nc3cc(O)ccc3[nH]2)cc1)c1ccccc1 CHEMBL5087008 IC50 1.45 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1cccc(C)c1 CHEMBL4780170 IC50 1.46 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(N3CCC(C(=O)O)C3)cc2F)N1CC(C)(C)F CHEMBL5077750 EC50 1.47 nM
Cn1cc(NC(=O)c2cc(NC(=O)CCS(C)(=O)=O)cn2C)cc1C(=O)NCCC(=O)NCCCCCC[C@@H]1Cc2cc(O)ccc2[C@H]2CC[C@]3(C)[C@@H](O)CC[C@H]3[C@H]12 CHEMBL5072592 IC50 1.48 nM
C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@H]2O CHEMBL286452 EC50 1.5 nM
CC1(c2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc2CCN1c1ccccc1 CHEMBL328810 IC50 1.5 nM
C[C@@H]1c2cc(O)ccc2O[C@@H](c2ccc(OCCN3CCCC3)cc2)[C@H]1c1ccc(O)cc1 CHEMBL181936 IC50 1.5 nM
C[C@H](CN1CCCC1)Oc1ccc([C@@H]2Oc3ccc(O)cc3[C@@H](C)[C@@H]2c2ccc(O)cc2)cc1 CHEMBL2113002 IC50 1.5 nM
Oc1ccc(-c2cc3cc(O)cc(Br)c3o2)cc1 CHEMBL183782 IC50 1.5 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CCSCC3)cc2)cc1 CHEMBL362718 IC50 1.5 nM
Cc1cc(Cl)ccc1-c1c(Cc2ccc(/C=C/C(=O)O)cc2)c2ccc(O)cc2oc1=O CHEMBL3427398 IC50 1.5 nM
CC1=C(c2ccc(C#N)cc2)C(c2ccc(OC[C@H](C)N3CC[C@@H](C)C3)cc2)Oc2ccc(O)cc21 CHEMBL4170549 IC50 1.5 nM
Oc1ccc2c(c1)CCCC(c1ccc3[nH]ncc3c1)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4476692 EC50 1.5 nM
O=C(O)/C=C/c1ccc(/C(=C(\c2ccc(F)cc2Cl)C2CCC2)c2ccc3nccn3c2)cc1 CHEMBL4560511 EC50 1.5 nM
COc1ccc(/C(=C(\c2ccc(/C=C/C(=O)O)cc2)c2ccc(-c3cn[nH]c3)cc2)C2CCC2)c(Cl)c1 CHEMBL4519174 EC50 1.5 nM
O=C(O)/C=C/c1ccc(/C(=C(\c2ccc(C(F)(F)F)cc2Cl)C2CCC2)c2ccc3nccn3c2)cc1 CHEMBL4444687 EC50 1.5 nM
CC/C(=C(\c1ccccc1)c1ccc(OCCN(C)C)cc1)c1ccccc1 CHEMBL83 IC50 1.5 nM
COc1cc(N2CCN(CCC3CCN(c4ncc([C@@H]5c6[nH]c7ccccc7c6C[C@@H](C)N5CC(C)(C)F)cn4)CC3)CC2)cc2c1C(=O)N(C1CCC(=O)NC1=O)C2 CHEMBL4745409 IC50 1.5 nM
NS(=O)(=O)Oc1ccc2c(C(=O)c3ccc(OCCN4CCCCC4)cc3)c(-c3ccc(O)cc3)sc2c1 CHEMBL5413467 Ki 1.5 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(N3CCOCC3)cc2F)N1CC(C)(C)F CHEMBL5076471 EC50 1.51 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1ccc(Cl)cc1Cl CHEMBL4776513 IC50 1.52 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(/C=C/C(N)=O)cc2F)N1CC(C)(C)F CHEMBL5079314 EC50 1.56 nM
CCC(=C(c1ccc(O)cc1)c1ccc(/C=C/C(=O)NCCCCCNC(=O)CCc2nc3ccc(OC)cc3[nH]2)cc1)c1ccccc1 CHEMBL5092721 IC50 1.56 nM
CC(C)CN1[C@H](c2ccc(/C=C/C(=O)O)cc2)c2ccc3[nH]ncc3c2CC1(C)C CHEMBL4586630 pIC50 1.585 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2cccc(OCCNCCCF)c2)N1CC(F)(F)F CHEMBL5404753 pIC50 1.585 nM
Cc1ccc(OCCNCCCF)cc1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1CC(F)(F)F CHEMBL5424734 pIC50 1.585 nM
Oc1ccc([C@@H]2Sc3ccc(O)cc3O[C@@H]2c2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL71584 IC50 1.6 nM
Oc1ccc(C2=C(c3ccc(OCCN4CCCCC4)cc3)Oc3ccc(O)cc3S2)cc1 CHEMBL418327 IC50 1.6 nM
CC1(c2ccc(OCCN3CCCC3)cc2)c2ccc(O)cc2CCN1c1ccc(F)cc1 CHEMBL101997 IC50 1.6 nM
CC1=CC[C@]2(O)C[C@H]1[C@H](c1ccc(O)cc1)OC2(C)C CHEMBL360127 EC50 1.6 nM
Oc1ccc2c(c1)O[C@H](c1ccc(OCCN3CCOCC3)cc1)C1=C2CCOc2cc(O)ccc21 CHEMBL1087811 IC50 1.6 nM
CCCc1c(-c2ccc(O)cc2)cn(-c2ccc(O)cc2)c1-c1ccc(O)cc1 CHEMBL2178794 EC50 1.6 nM
O=C(O)/C=C/c1ccc(Cc2c(-c3ccc(OC(F)(F)F)cc3)c(=O)oc3cc(O)ccc23)cc1 CHEMBL3427393 IC50 1.6 nM
CC(C)CN1[C@H](c2c(F)cc(/C=C/C(=O)O)cc2F)c2ccc(O)cc2CC1(C)C CHEMBL3775766 IC50 1.6 nM
O=C(O)/C=C/c1ccc(/C(=C(\c2ccc(F)cc2Cl)C2CCC2)c2ccc(N3CCOCC3)cc2)cc1 CHEMBL4552977 EC50 1.6 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1ccc(F)cc1Cl CHEMBL4744609 IC50 1.6 nM
Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCn3cc(COCCOc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)nn3)cc2)c2ccc(O)cc12 CHEMBL4873534 IC50 1.6 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(Cl)cc(-c3ccc(C(=O)O)cc3)cc2Cl)N1CC(C)(C)F CHEMBL5078199 EC50 1.61 nM
CCC(=C(c1ccc(O)cc1)c1ccc(/C=C/C(=O)NCCCCNC(=O)CCc2nc3cc(O)ccc3[nH]2)cc1)c1ccccc1 CHEMBL5092334 IC50 1.62 nM
O=C(/C=C/c1ccc(C(=C2CCCCC2)c2ccc(O)cc2)cc1)NCCCNC(=O)/C=C/c1ccc(C(=C2CCCCC2)c2ccc(O)cc2)cc1 CHEMBL4790840 IC50 1.67 nM
Oc1ccc2c(c1)CCC(c1ccccc1)N2Cc1ccc(OCCN2CCCCC2)cc1 CHEMBL60538 Ki 1.7 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(C3CCNCC3)cc2)cc1 CHEMBL125119 IC50 1.7 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCCN3CCCC3)cc2)cc1 CHEMBL361751 IC50 1.7 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CC[C@@H](O)C3)cc2)cc1 CHEMBL185114 IC50 1.7 nM
Oc1ccc(C2=C(c3ccc(OCCN4CCCCC4)cc3)c3ccc(O)cc3C2)cc1 CHEMBL381645 Ki 1.7 nM
C[C@@H]1Cc2cc(O)ccc2[C@@H](c2ccc(/C=C/C(=O)O)cc2)N1c1ccc(OC(F)(F)F)cc1 CHEMBL3775795 IC50 1.7 nM
CCCCCC(=O)/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1 CHEMBL4101656 Ki 1.7 nM
O=C(O)/C=C/c1ccc(/C(=C(\c2ccccc2)C2CCC2)c2ccc(-c3cncs3)cc2)cc1 CHEMBL4513432 EC50 1.7 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(-c3ccc(C(=O)O)cc3Cl)cc2F)N1CC(C)(C)F CHEMBL5088613 EC50 1.7 nM
O=C(c1ccc(N2CCN(C(=O)c3ccccc3Cl)CC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12 CHEMBL180973 IC50 1.72 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1ccc(Cl)cc1 CHEMBL4743379 IC50 1.74 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1cccc(C(F)(F)F)c1 CHEMBL4745512 IC50 1.75 nM
O=C(Nc1ccc2cc[nH]c2c1)c1cccc(C(F)(F)F)c1 CHEMBL4590512 IC50 1.76 nM
CC1(c2ccc(OCCN3CCCC3)cc2)c2ccc(O)cc2CCN1c1ccccc1 CHEMBL98558 pIC50(uM) 1.799 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CCC(O)CC3)cc2)cc1 CHEMBL184372 IC50 1.8 nM
CCCCCCCCCCCCCCCCCCNCCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1 CHEMBL3805385 IC50 1.8 nM
CCCCOC(=O)/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1 CHEMBL4099166 Ki 1.8 nM
N#Cc1ccc(/C(=C(\c2ccc(/C=C/C(=O)O)cc2)c2ccc(-c3cncs3)cc2)C2CCC2)c(Cl)c1 CHEMBL4456861 EC50 1.8 nM
C[C@]12CC[C@@H]3c4ccc(O)cc4C[C@@H](CCCCCCCCC[S@@](=N)(=O)CCCC(F)(F)C(F)(F)F)[C@H]3[C@@H]1CC[C@@H]2O CHEMBL4782243 IC50 1.8 nM
O=S1(=O)CCC(c2ccc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)CC1 CHEMBL428926 Ki 1.89 nM
CC1(c2ccc(OCCN3CCCCC3)cc2)c2ccc(O)cc2CCN1c1ccc(F)cc1 CHEMBL101083 IC50 1.9 nM
Oc1ccc(C2=C(c3ccc(OCCN4CCC4)cc3)c3ccccc3OCC2)cc1 CHEMBL470993 IC50 1.9 nM
N#Cc1cc(Cl)ccc1/C(=C(\c1ccc(/C=C/C(=O)O)cc1)c1ccc(-c2cncs2)cc1)C1CCC1 CHEMBL4582772 EC50 1.9 nM
O=C(O)/C=C/c1ccc(/C(=C(\c2ccc(C(F)(F)F)cc2Cl)C2CCC2)c2ccc(N3CCOCC3)cc2)cc1 CHEMBL4440665 EC50 1.9 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2cnc(N3CCC4(CC3)CC(CN3CC5(CCN(c6ccc7c(c6)CN(C6CCC(=O)NC6=O)C7=O)CC5)C3)C4)nc2)N1CC(C)(C)F CHEMBL4745755 IC50 1.9 nM
Cc1ccccc1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(OCCN2CCC2)cc1 CHEMBL4516021 pIC50 1.905 nM
COc1cc(C(=O)O)cc(Cl)c1-c1cc(F)c([C@@H]2c3[nH]c4ccccc4c3C[C@@H](C)N2CC(C)(C)F)c(F)c1 CHEMBL5077488 EC50 1.92 nM
CC(C)(F)CN1[C@@H]2CCC[C@@]1(c1c(F)cc(OCCN3CC(CF)C3)cc1F)c1[nH]c3ccccc3c1C2 CHEMBL4516412 pIC50 1.995 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)ccc(OCCNCCCF)c2F)N1C[C@H](C)C(=O)O CHEMBL5430566 pIC50 1.995 nM
Cc1cc(O)cc2c1S[C@@H](c1ccc(O)cc1)[C@@H](c1ccc(OCCN3CCCCC3)cc1)O2 CHEMBL93793 IC50 2.0 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CCC4(CC3)OCCO4)cc2)cc1 CHEMBL185480 IC50 2.0 nM
OC[C@H]1CCCN1CCOc1ccc([C@@H]2Oc3ccc(O)cc3S[C@@H]2c2ccc(O)cc2)cc1 CHEMBL360802 IC50 2.0 nM
O=S1(=O)CCN(CCOc2ccc([C@@H]3Oc4ccc(O)cc4S[C@@H]3c3ccc(O)cc3)cc2)CC1 CHEMBL185383 IC50 2.0 nM
CSC1=C(c2ccc(O)cc2)C(=O)c2cc(O)cc(O)c21 CHEMBL190038 IC50 2.0 nM
Cc1c([C@H](C)NC(=O)Cc2c(-c3ccccc3)[nH]c3ccccc23)n(Cc2ccc(OCCN3CCCCC3)cc2)c2ccc(O)cc12 CHEMBL240438 IC50 2.0 nM
CCCCCc1cc2cc(O)ccc2c(Oc2ccc(/C=C/C(=O)O)cc2)c1-c1ccccc1 CHEMBL489585 Ki 2.0 nM
CCCC(Cc1ccc(O)cc1)c1ccc(O)cc1 CHEMBL574524 EC50 2.0 nM
C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@]2(O)c1cn(CC[C@H]2O[C@@H]3O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@@H](O[C@H]9[C@H](O)[C@@H](O)[C@@H](O[C@H]2[C@H](O)[C@H]3O)O[C@@H]9Cn2cc([C@]3(O)CC[C@H]9[C@@H]%10CCc%11cc(O)ccc%11[C@H]%10CC[C@@]93C)nn2)O[C@@H]8Cn2cc([C@]3(O)CC[C@H]8[C@@H]9CCc%10cc(O)ccc%10[C@H]9CC[C@@]83C)nn2)O[C@@H]7Cn2cc([C@]3(O)CC[C@H]7[C@@H]8CCc9cc(O)ccc9[C@H]8CC[C@@]73C)nn2)O[C@@H]6Cn2cc([C@]3(O)CC[C@H]6[C@@H]7CCc8cc(O)ccc8[C@H]7CC[C@@]63C)nn2)O[C@@H]5Cn2cc([C@]3(O)CC[C@H]5[C@@H]6CCc7cc(O)ccc7[C@H]6CC[C@@]53C)nn2)O[C@@H]4Cn2cc([C@]3(O)CC[C@H]4[C@@H]5CCc6cc(O)ccc6[C@H]5CC[C@@]43C)nn2)nn1 CHEMBL605828 EC50 2.0 nM
O=C(N1CCc2cc(O)ccc2C1)C(F)(F)F CHEMBL1213617 Ki 2.0 nM
Oc1ccc(C(=Nc2ccc(Cl)cc2)c2ccc(O)cc2)cc1 CHEMBL3234619 EC50 2.0 nM
Oc1ccc(C(=Nc2ccc(F)cc2)c2ccc(O)cc2)cc1 CHEMBL3234621 EC50 2.0 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1ccc2[nH]ncc2c1)c1ccncc1Cl CHEMBL3581680 EC50 2.0 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1ccc2[nH]ncc2c1)c1cccc(Cl)c1 CHEMBL3581683 EC50 2.0 nM
COc1cc(/C=C/c2ccc(OS(=O)(=O)[C@@H]3C[C@@H]4O[C@H]3C(c3ccc(O)cc3)=C4c3ccc(O)cc3)cc2)cc(OC)c1 CHEMBL4204245 EC50 2.0 nM
Cc1ccc(OS(=O)(=O)C2CC3OC2C(c2ccc(/C=C/c4cc(O)cc(O)c4)cc2)=C3c2ccc(O)cc2)cc1 CHEMBL4206798 IC50 2.0 nM
Oc1ccc2c(c1)CCCC(c1ccc(SC(F)(F)F)cc1)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4463394 EC50 2.0 nM
Oc1ccc2c(c1)CCCC(c1ccc(OC(F)(F)F)cc1)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4522878 EC50 2.0 nM
Oc1ccc(C2=C(c3ccc(OCCN4CCCC4)cc3)c3cc(O)ccc3CC2)cc1 CHEMBL4444208 EC50 2.0 nM
O=C(NCCCCOc1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1)C12CC3CC(CC1C3)C2 CHEMBL4205118 IC50 2.0 nM
O=C(NCCCCOc1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1)[C@H]1CC[C@H](C(F)(F)F)CC1 CHEMBL4210411 IC50 2.0 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2cnc(N3CCC(CCN4CCOC5(CC4)CCN(c4ccc6c(c4)CN(C4CCC(=O)NC4=O)C6=O)CC5)CC3)nc2)N1CC(C)(C)F CHEMBL4792381 IC50 2.0 nM
C[C@]12CC[C@@H]3c4ccc(O)cc4C[C@@H](CCCCCCCCC[S@+]([O-])CCCC(F)(F)C(F)(F)F)[C@H]3[C@@H]1CC[C@@H]2O CHEMBL4760678 IC50 2.0 nM
FCCCN1CC(Oc2ccc(Oc3c(-c4ccc(F)cc4CC(F)(F)F)sc4c3ccc3[nH]ncc34)cc2F)C1 CHEMBL5191700 IC50 2.0 nM
CC(C)CN1[C@H](c2ccc(/C=C/C(=O)O)cc2)c2[nH]c3ccccc3c2C[C@H]1C CHEMBL3623001 pIC50 2.089 nM
Oc1ccc(C2=C(c3ccc(C(F)(F)F)cc3)c3ccc(O)cc3C2)cc1 CHEMBL197080 Ki 2.1 nM
O=C(O)/C=C/c1ccc(/C(=C(\c2ccccc2)C2CCC2)c2ccc(-c3cn[nH]c3)cc2)cc1 CHEMBL4451352 EC50 2.1 nM
Cc1ccccc1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(OC2CN(CCCF)C2)cc1 CHEMBL4448178 IC50 2.1 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2cnc(N3CCC(OCCN4CCN(c5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)CC4)CC3)nc2)N1CC(C)(C)F CHEMBL4785047 IC50 2.1 nM
Cc1cc(C)nc(N2CCN(c3ccc(C(=O)c4c(-c5ccc(O)cc5)sc5cc(O)ccc45)cc3)CC2)n1 CHEMBL182237 IC50 2.12 nM
O=C(c1ccc(N2CCN(C(=O)c3ccc([N+](=O)[O-])cc3)CC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12 CHEMBL362020 IC50 2.15 nM
Nc1c(/C=N/O)ccc(-c2ccccc2)c1-c1ccccc1 CHEMBL131163 Ki 2.2 nM
OCC1CCN(CCOc2ccc([C@@H]3Oc4ccc(O)cc4S[C@@H]3c3ccc(O)cc3)cc2)CC1 CHEMBL184431 IC50 2.2 nM
NC(=O)C1CCN(CCOc2ccc([C@@H]3Oc4ccc(O)cc4S[C@@H]3c3ccc(O)cc3)cc2)CC1 CHEMBL184491 IC50 2.2 nM
Oc1ccc2c(c1)O[C@H](c1ccc(OCCN3CCCCCC3)cc1)C1=C2CCOc2cc(O)ccc21 CHEMBL1087545 IC50 2.2 nM
Cc1cc(O)ccc1C1=C(c2ccc(O)cc2C)[C@H]2[C@@H](S(=O)(=O)Oc3ccccc3F)C[C@@H]1[S+]2[O-] CHEMBL2031520 EC50 2.2 nM
O=C(O)/C=C/c1ccc(Cc2c(-c3ccc(F)cc3Cl)c(=O)oc3cc(O)ccc23)cc1 CHEMBL3427395 IC50 2.2 nM
CC(C)(F)CN1[C@H](c2ccc(/C=C/C(=O)O)cc2)c2ccc(O)cc2CC1(C)C CHEMBL3774447 IC50 2.2 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2cnc(OC3CCC4(CC3)CCN(CC3CCN(c5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)CC3)CC4)nc2)N1CC(C)(C)F CHEMBL4754618 IC50 2.2 nM
CC(F)(F)c1cc(F)ccc1-c1sc2cc(B(O)O)ccc2c1Oc1ccc(OCCN2CC[C@@H](CF)C2)cc1 CHEMBL5189071 EC50 2.2 nM
CC(F)(F)c1cc(F)c(F)cc1-c1sc2c(ccc3[nH]ncc32)c1Oc1ccc(NC2CN(CCCF)C2)cc1 CHEMBL5207893 EC50 2.2 nM
CCC(=C(c1ccc(O)cc1)c1ccc(/C=C/C(=O)NCCCCNC(=O)CCc2nc3cc(OC)ccc3[nH]2)cc1)c1ccccc1 CHEMBL5075366 IC50 2.22 nM
CC/C(=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1 CHEMBL279301 IC50 2.24 nM
Oc1ccc([C@@H]2Oc3ccc(O)cc3[C@@H]3CCC[C@@H]32)cc1 CHEMBL278703 Ki 2.29 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(COCCN3CCCCC3)cc2)cc1 CHEMBL122237 IC50 2.3 nM
O=C(/C=C/c1ccc(C(=C2CCCCC2)c2ccc(O)cc2)cc1)NCCCCCNC(=O)/C=C/c1ccc(C(=C2CCCCC2)c2ccc(O)cc2)cc1 CHEMBL4790191 IC50 2.35 nM
C[C@@H]1CCN(CCOc2ccc([C@@H]3Oc4ccc(O)cc4[C@@H](C)[C@@H]3c3ccc(O)cc3)cc2)C1 CHEMBL369724 IC50 2.4 nM
Oc1ccc2c(c1)CO[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 CHEMBL183162 IC50 2.4 nM
Oc1ccc2c(c1)O[C@@H](c1ccc(OCCN3CCCCCC3)cc1)C1=C2CCOc2cc(O)ccc21 CHEMBL1086774 IC50 2.4 nM
C[C@]12C[C@H](c3ccc(OCCOCCOCCN=[N+]=[N-])cc3)[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@H]2O CHEMBL2036418 Ki 2.4 nM
CCCCCCCCNCCOc1ccc(C(CCC)(CCC)c2ccc(O)c(C)c2)cc1C CHEMBL4176843 IC50 2.4 nM
N#Cc1ccc(C(=O)Nc2ccc3cc[nH]c3c2)cc1 CHEMBL4435453 IC50 2.4 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1ccccc1OC(F)(F)F CHEMBL4765054 IC50 2.41 nM
Oc1ccc2c(c1)S[C@H](C1CCCC1)[C@H](c1ccc(OCCN3CCCCC3)cc1)O2 CHEMBL431611 IC50 2.5 nM
Oc1ccc(C2CCc3cc(O)ccc3N2c2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL293297 Ki 2.5 nM
CCc1c(-c2ccc(O)cc2)oc(-c2ccc(O)cc2)c1-c1ccc(OC)cc1 CHEMBL315475 Ki 2.5 nM
C[C@H]1CCN([C@@H](C)COc2ccc([C@@H]3Oc4ccc(O)c(F)c4[C@@H](C)[C@@H]3c3ccc(O)cc3)cc2)C1 CHEMBL359671 IC50 2.5 nM
C[C@@H](CN1CCCC1)Oc1ccc([C@@H]2Oc3ccc(O)cc3S[C@@H]2c2ccc(O)cc2)cc1 CHEMBL181944 IC50 2.5 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CCC(F)CC3)cc2)cc1 CHEMBL183084 IC50 2.5 nM
Oc1ccc2c(c1)O[C@@H](c1ccc(OCCN3CCCC3)cc1)C1=C2CCOc2cc(O)ccc21 CHEMBL1086776 IC50 2.5 nM
CC1=C(c2ccc(F)cc2)[C@H](c2ccc(OCCN3CC(CF)C3)cc2)Oc2ccc(N)cc21 CHEMBL4531089 IC50 2.5 nM
CC(c1cc(F)ccc1-c1sc2c(ccc3[nH]ncc32)c1Oc1ccc(OC2CN(CCCF)C2)cc1)C(F)(F)F CHEMBL5198039 EC50 2.5 nM
COc1cc(Oc2c(-c3cc(F)c(F)cc3C(C)(F)F)sc3c2ccc2[nH]ncc23)ccc1NC1CN(CCCF)C1 CHEMBL5198894 IC50 2.5 nM
CC(F)(F)c1cc(F)c(F)cc1-c1sc2c(ccc3[nH]ncc32)c1Oc1ccc(OC2CN(CCCF)C2)cc1 CHEMBL5181826 IC50 2.5 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(Cl)cc(/C=C/C(=O)O)cc2Cl)N1CC(C)(C)F CHEMBL5087025 EC50 2.51 nM
COc1cc(/C=C/C(=O)O)ccc1[C@]1(C)c2ccc3[nH]ncc3c2C[C@@H](C)N1CC(C)(C)F CHEMBL4536329 pIC50 2.512 nM
COc1cc2[nH]ncc2c2c1[C@@H](c1ccc(NC3CN(CCCF)C3)cn1)N(CC(F)(F)F)[C@H](C)C2 CHEMBL4757584 pIC50 2.512 nM
Oc1ccc2c(c1)S[C@H](C1CCCCC1)[C@H](c1ccc(OCCN3CCCCC3)cc1)O2 CHEMBL85090 IC50 2.6 nM
CC1(c2ccc(OCCN3CCCCC3)cc2)c2ccc(O)cc2CCN1c1ccccc1 CHEMBL101807 IC50 2.6 nM
CC(C)c1ccc(N2CCc3cc(O)ccc3C2(C)c2ccc(OCCN3CCCC3)cc2)cc1 CHEMBL98470 IC50 2.6 nM
CC1=CC[C@@]2(CO)CO[C@@H](c3ccc(O)c(F)c3)[C@@H]1C2 CHEMBL181245 EC50 2.6 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CCCC3)cc2)cc1 CHEMBL362623 IC50 2.6 nM
Cc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1 CHEMBL3765549 EC50 2.6 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1ccc2[nH]ncc2c1)c1ccccc1 CHEMBL3581641 EC50 2.6 nM
CC/C(=C(\c1ccccc1)c1ccc(/C=C/C(=O)O)cc1)c1ccccc1 CHEMBL33899 IC50 2.6 nM
CC(F)(F)c1cc(Cl)ccc1-c1sc2cc(C(=O)O)ccc2c1Oc1ccc(OCCN2CC(CF)C2)cc1 CHEMBL5206306 EC50 2.6 nM
CCC(=C(c1ccc(O)cc1)c1ccc(/C=C/C(=O)NCCCCCCNC(=O)CCc2nc3cc(OC)ccc3[nH]2)cc1)c1ccccc1 CHEMBL5091421 IC50 2.61 nM
O=C1CCC(=O)N1CCCOc1ccc([C@H]2Oc3cc(O)ccc3C3=C2c2ccc(O)cc2OCC3)cc1 CHEMBL1087557 IC50 2.63 nM
O=C(c1ccc(N2CCN(C(=O)c3ccco3)CC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12 CHEMBL178857 IC50 2.65 nM
Oc1ccc(C[C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL313941 IC50 2.7 nM
COC(=O)C(Cc1ccc(O)cc1)c1ccc(O)cc1 CHEMBL335412 EC50 2.7 nM
CCOc1ccc2c(c1)CCCC(c1ccccc1)=C2c1ccc(O)cc1 CHEMBL3290285 EC50 2.7 nM
Cc1cc(F)ccc1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(OCCN2CC(CF)C2)cc1 CHEMBL4578883 IC50 2.7 nM
Cc1c(-c2ccc(O)cc2)nn(-c2ccc(O)cc2)c1-c1ccc(OCCN2CCCCC2)cc1 CHEMBL520107 Ki 2.7 nM
CCC(=C(c1ccc(O)cc1)c1ccc(/C=C/C(=O)NCCCNC(=O)CCc2nc3cc(O)ccc3[nH]2)cc1)c1ccccc1 CHEMBL5088360 IC50 2.72 nM
Cc1ccc(C(=O)N2CCN(c3ccc(C(=O)c4c(-c5ccc(O)cc5)sc5cc(O)ccc45)cc3)CC2)cc1 CHEMBL180702 IC50 2.74 nM
CCC(=C(c1ccc(O)cc1)c1ccc(/C=C/C(=O)NCCNC(=O)CCc2nc3cc(OC)ccc3[nH]2)cc1)c1ccccc1 CHEMBL5085956 IC50 2.75 nM
Cc1cc(O)ccc1C1=C(c2ccc(O)cc2C)[C@H]2[C@@H](S(=O)(=O)Oc3ccccc3Cl)C[C@@H]1[S+]2[O-] CHEMBL2031521 EC50 2.8 nM
O=C(O)/C=C/c1ccc(/C(=C(\c2ncc(C(F)(F)F)cc2Cl)C2CCC2)c2ccc(-c3cn[nH]c3)cc2)cc1 CHEMBL4572383 EC50 2.8 nM
Cc1cc(O)cc2c1O[C@@H](c1ccc(O)cc1)[C@H]1CCC[C@@H]21 CHEMBL399832 Ki 2.82 nM
Oc1ccc2c(c1)sc1c3cc(O)ccc3n(Cc3ccc(OCCN4CCCCC4)cc3)c21 CHEMBL196131 IC50 2.84 nM
Oc1ccc([C@H]2Oc3ccc(O)cc3[C@H]3CCCC[C@H]32)cc1 CHEMBL234462 Ki 2.88 nM
CC1(c2ccc(OCCN3CCCC3)cc2)c2ccc(O)cc2CCN1c1cccc(Cl)c1 CHEMBL319678 pIC50(uM) 2.897 nM
Cc1ccc(N2CCc3cc(O)ccc3C2(C)c2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL174502 pIC50(uM) 2.897 nM
Oc1ccc(CC(c2ccc(O)cc2)C(F)(F)F)cc1 CHEMBL132868 EC50 2.9 nM
N#C[C@H](Cc1ccc(O)cc1)c1ccc(O)cc1 CHEMBL198159 EC50 2.9 nM
CC1(c2ccc(OCCN3CCCC3)cc2)c2ccc(O)cc2CCN1c1cccc(F)c1 CHEMBL319211 pIC50(uM) 2.999 nM
CC(C)C[C@H]1Sc2cc(O)ccc2O[C@H]1c1ccc(OCCN2CCCCC2)cc1 CHEMBL85650 IC50 3.0 nM
Oc1ccc2c(c1)S[C@H](CC1CCCC1)[C@H](c1ccc(OCCN3CCCCC3)cc1)O2 CHEMBL315271 IC50 3.0 nM
Oc1ccc([C@@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL2111532 IC50 3.0 nM
Oc1cccc(C2Sc3cc(O)ccc3OC2c2ccc(OCCN3CCCCC3)cc2)c1 CHEMBL91807 IC50 3.0 nM
Oc1ccc([C@@H]2Sc3cc(O)ccc3O[C@@H]2c2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL539927 IC50 3.0 nM
C[C@@H]1CCN(CCOc2ccc([C@@H]3Oc4ccc(O)cc4S[C@@H]3c3ccc(O)cc3)cc2)C1 CHEMBL183584 IC50 3.0 nM
O=C1C(c2ccc(O)cc2)=C(c2ccccc2)c2cc(O)cc(O)c21 CHEMBL191836 IC50 3.0 nM
CC(C)n1nc(-c2ccc(O)cc2)c2cccc(C(F)(F)F)c21 CHEMBL386502 IC50 3.0 nM
Oc1ccc(C(=Nc2ccccc2)c2ccc(O)cc2)cc1 CHEMBL3234612 EC50 3.0 nM
CCOc1ccc2c(c1)CCCC(c1ccccc1)=C2c1ccc(OCCN(C)C)cc1 CHEMBL3290287 IC50 3.0 nM
CNCCOc1ccc(C2=C(c3ccccc3)CCCc3cc(O)ccc32)cc1 CHEMBL3290288 IC50 3.0 nM
O=C(O)/C=C/c1ccc(Cc2c(-c3ccc(F)cc3F)c(=O)oc3cc(O)ccc23)cc1 CHEMBL3427394 IC50 3.0 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1ccc2[nH]ccc2c1)c1ccccc1 CHEMBL3581638 EC50 3.0 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1ccc2[nH]ncc2c1)c1ccccc1C#N CHEMBL3581685 EC50 3.0 nM
CC(C)c1ccc(N2CCc3cc(O)ccc3C2(C)c2ccc(/C=C/C(=O)O)cc2)cc1F CHEMBL4069539 IC50 3.0 nM
Cn1nnc(/C=C/c2ccc(Oc3c(-c4ccc(O)cc4)sc4cc(O)ccc34)cc2)n1 CHEMBL4087929 IC50 3.0 nM
COCc1ccccc1-c1sc2cc(O)ccc2c1Oc1ccc(/C=C/C(=O)O)cc1 CHEMBL4064146 IC50 3.0 nM
CCc1ccccc1OS(=O)(=O)C1CC2OC1C(c1ccc(/C=C/c3cc(OC)cc(OC)c3)cc1)=C2c1ccc(O)cc1 CHEMBL4208076 IC50 3.0 nM
O=C(O)c1ccc2c(c1)CCCC(c1cccc(F)c1Cl)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4574995 EC50 3.0 nM
O=C(NCCCOc1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1)C12CC3CC(CC(C3)C1)C2 CHEMBL4204624 IC50 3.0 nM
CC1=C(c2ccc(F)cc2)[C@H](c2ccc(OCCN3CC(CF)C3)cc2)Oc2ccc(F)cc21 CHEMBL4534455 IC50 3.0 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1C(=O)C1CC1 CHEMBL4873267 DC50 3.0 nM
Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(OCCN2CC[C@H](CF)C2)cc1 CHEMBL4436707 pIC50 3.02 nM
O=C(c1ccc(N2CCN(C(=O)c3ccccc3O)CC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12 CHEMBL427496 IC50 3.05 nM
CC1(c2ccc(OCCN3CCCCC3)cc2)c2ccc(O)cc2CCN1c1ccc(Cl)cc1 CHEMBL103294 pIC50(uM) 3.097 nM
C#CC(Cc1ccc(O)cc1)c1ccc(O)cc1 CHEMBL334798 EC50 3.1 nM
Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 CHEMBL2113354 IC50 3.1 nM
CSC1=C(c2ccc(O)cc2)C(=O)c2ccc(O)cc21 CHEMBL192765 IC50 3.1 nM
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(NC3(C)CN(CCCF)C3)cn2)N1CC(F)(F)F CHEMBL4756084 pIC50 3.162 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1cccc(Cl)c1Cl CHEMBL4800401 IC50 3.18 nM
Cc1cc(F)ccc1-c1c(Oc2ccc(/C=C/C(=O)O)cc2)c2ccc(O)c(F)c2oc1=O CHEMBL3427407 IC50 3.2 nM
COc1cc(N2CCN(CC3CCN(c4ncc([C@@H]5c6[nH]c7ccccc7c6C[C@@H](C)N5CC(C)(C)F)cn4)CC3)CC2)cc2c1C(=O)N(C1CCC(=O)NC1=O)C2 CHEMBL4789907 IC50 3.2 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2ccc(/C=C/C(=O)O)cn2)N1CC(C)(C)F CHEMBL5093320 EC50 3.23 nM
CC1(c2ccc(OCCN3CCCC3)cc2)c2ccc(O)cc2CCN1c1ccc(Cl)cc1 CHEMBL100763 IC50 3.3 nM
C[C@@H]1C[C@H]2[C@@H](C1)c1cc(O)ccc1O[C@H]2c1ccc(O)cc1 CHEMBL236045 Ki 3.3 nM
CN(C)CCOc1ccc([C@H]2Oc3cc(O)ccc3C3=C2c2ccc(O)cc2OCC3)cc1 CHEMBL1083186 IC50 3.3 nM
Oc1ccc2c(c1)OCCC1=C2[C@@H](c2ccc(OCCN3CCCCCC3)cc2)Oc2cc(F)ccc21 CHEMBL1082224 IC50 3.3 nM
CCOC(=O)/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1 CHEMBL4082698 Ki 3.3 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2cnc(N3CCC(CCN4CCN(c5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)CC4)CC3)nc2)N1CC(C)(C)F CHEMBL4781967 IC50 3.3 nM
CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 CHEMBL2355051 AC50 3.3 nM
O=S(=O)(Nc1ccc2cc[nH]c2c1)c1ccc(F)cc1 CHEMBL4539135 IC50 3.31 nM
Oc1ccc2c(c1)sc1c3cc(O)ccc3n(Cc3ccc(OCCN4CCCCCC4)cc3)c21 CHEMBL264216 IC50 3.34 nM
CC1CCCC(C)N1CCOc1ccc([C@@H]2Oc3ccc(O)cc3S[C@@H]2c2cccc(O)c2)cc1 CHEMBL90794 IC50 3.4 nM
Oc1ccc2c(c1)O[C@@H](c1ccc(OCCN3CCCCC3)cc1)C1=C2CCOc2cc(O)ccc21 CHEMBL1088631 IC50 3.4 nM
N#CC(Cc1ccc(O)cc1)c1ccc(O)cc1 CHEMBL334773 EC50 3.4 nM
CC/C(=C(\c1ccc(O)cc1)c1ccc(OCCNCCCCCCCCCCF)cc1)c1ccccc1 CHEMBL3586195 IC50 3.4 nM
CCC(=C(c1ccc(O)cc1)c1ccc(/C=C/C(=O)NCCCCCCNC(=O)CCc2nc3cc(O)ccc3[nH]2)cc1)c1ccccc1 CHEMBL5094540 IC50 3.41 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2cc(F)c(/C=C/C(=O)O)c(F)c2)N1CC(C)(C)F CHEMBL5087621 EC50 3.48 nM
Cc1ccc(N2CCc3cc(O)ccc3C2(C)c2ccc(OCCN3CCCC3)cc2)cc1 CHEMBL327515 pIC50(uM) 3.499 nM
CCCCN(C)C(=O)CCCCCCCCCCS[C@@H]1Cc2cc(O)ccc2[C@H]2CC[C@]3(C)[C@@H](O)CC[C@H]3[C@@H]21 CHEMBL1627354 IC50 3.5 nM
CC(C)(C#N)c1cc(CSc2ccc(OS(N)(=O)=O)cc2)cc(Cn2cncn2)c1 CHEMBL4444074 IC50 3.5 nM
C/C=C(C(=C/C)/c1ccc(O)cc1)\c1ccc(O)cc1 CHEMBL1018 AC50 3.5 nM
CC/C(=C(/c1ccc(O)cc1)c1ccc(/C=C/C(=O)NCCCCCNC(=O)/C=C/c2ccc(/C(=C(\CC)c3ccccc3)c3ccc(O)cc3)cc2)cc1)c1ccccc1 CHEMBL4755319 IC50 3.52 nM
O=C(c1ccc(N2CCN(C(=O)c3ccccc3[N+](=O)[O-])CC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12 CHEMBL360978 IC50 3.58 nM
CN1CCCN(c2ccc([C@@H]3Oc4ccc(O)cc4S[C@@H]3c3ccc(O)cc3)cc2)CC1 CHEMBL121879 IC50 3.6 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(N3CCCNCC3)cc2)cc1 CHEMBL340606 IC50 3.6 nM
CCCCCCCCCCNCCOc1ccc(/C(=C(/CC)c2ccccc2)c2ccc(O)cc2)cc1 CHEMBL3586191 IC50 3.6 nM
CNc1c(/C=N/O)ccc(-c2ccccc2)c1-c1ccccc1 CHEMBL130030 Ki 3.7 nM
CNc1c(/C=N/O)ccc(-c2ccc(O)cc2)c1-c1ccccc1 CHEMBL377849 Kd 3.7 nM
O=C(O)/C=C/c1ccc(Cc2c(-c3ccc(Cl)cc3)c(=O)oc3cc(O)ccc23)cc1 CHEMBL3427390 IC50 3.7 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCCCCN3CCN(c4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)cc2F)N1CC(C)(C)F CHEMBL4791102 IC50 3.7 nM
CCCc1ccc(C(=O)N(c2ccc(O)cc2)c2ccc(O)cc2)cc1 CHEMBL3645263 Ki 3.75 nM
CCc1c(-c2ccc(O)cc2)oc(-c2ccccc2)c1-c1ccc(OCCN2CCCCC2)cc1 CHEMBL432371 Ki 3.8 nM
Oc1cccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CCOCC3)cc2)c1 CHEMBL92027 IC50 3.8 nM
Oc1ccc2c(c1)SC(c1ccc(F)cc1)C(c1ccc(OCCN3CCCCC3)cc1)O2 CHEMBL93546 IC50 3.8 nM
COc1ccc(-c2c(Cc3ccc(/C=C/C(=O)O)cc3)c3ccc(O)cc3oc2=O)cc1 CHEMBL3427392 IC50 3.8 nM
Cc1cccc(CN(c2ccc(O)cc2)c2ccc(O)cc2)c1C CHEMBL3645264 Ki 3.81 nM
Oc1ccc2c(c1)S[C@H](CC1CCCCC1)[C@H](c1ccc(OCCN3CCCCC3)cc1)O2 CHEMBL85881 IC50 3.9 nM
O=C(c1ccc(OCCN2CCCCC2)cc1)c1oc2cc(O)ccc2c(=O)c1-c1ccc(O)cc1 CHEMBL285483 Ki 3.9 nM
OC[C@@H]1CCCN1CCOc1ccc([C@@H]2Oc3ccc(O)cc3S[C@@H]2c2ccc(O)cc2)cc1 CHEMBL359774 IC50 3.9 nM
Oc1ccc(C2=C(c3ccc(F)cc3)c3ccc(O)cc3C2)cc1 CHEMBL371236 EC50 3.9 nM
Cc1cc(F)ccc1-c1c(Cc2ccc(/C=C/C(=O)O)cc2)c2ccc(O)cc2oc1=O CHEMBL3427397 IC50 3.9 nM
CC(F)(F)c1cc(Cl)ccc1-c1sc2cc(C(=O)O)ccc2c1Oc1ccc(OC2CN(CCCF)C2)cc1 CHEMBL5194962 EC50 3.9 nM
CC(F)(F)c1cc(F)c(F)cc1-c1sc2c(ccc3[nH]ncc32)c1Oc1ccc(OC2CN(CCCF)C2)c(F)c1 CHEMBL5205546 EC50 3.9 nM
Cc1ccccc1C(=O)N1CCN(c2ccc(C(=O)c3c(-c4ccc(O)cc4)sc4cc(O)ccc34)cc2)CC1 CHEMBL182157 IC50 3.94 nM
CC(C)CN1CCc2cc(O)ccc2[C@H]1c1ccc(/C=C/C(=O)O)cc1 CHEMBL3775824 pIC50 3.981 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2cccc(OCCNCCCF)c2)N1CC1(F)COC1 CHEMBL5400175 pIC50 3.981 nM
CC1C(=O)c2cc(O)ccc2OC1c1ccc(O)cc1 CHEMBL113704 EC50 4.0 nM
C[C@]12CCc3c(sc4cc(O)ccc34)[C@@H]1CC[C@@H]2O CHEMBL135732 Ki 4.0 nM
Oc1cccc([C@H]2Sc3cc(O)ccc3S[C@H]2c2ccc(OCCN3CCCCC3)c(Br)c2)c1 CHEMBL125362 IC50 4.0 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3S[C@H]2c2ccc(OCCN3CCCC3)c(Br)c2)cc1 CHEMBL123025 IC50 4.0 nM
Oc1cccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(OCCN3CCCCC3)cc2)c1 CHEMBL93705 IC50 4.0 nM
CN(C)CCOc1ccc(/C(=C(/CCCl)c2ccccc2)c2ccc(O)cc2)cc1 CHEMBL1402 IC50 4.0 nM
Cc1c([C@H](C)NC(=O)Cc2c(-c3ccccc3)[nH]c3ccccc23)n(Cc2ccc(OCCN3CC[C@H](C)C3)cc2)c2ccc(O)cc12 CHEMBL437190 IC50 4.0 nM
CCCCc1cc2cc(O)ccc2c(Oc2ccc(/C=C/C(=O)O)cc2)c1-c1ccccc1 CHEMBL490198 Ki 4.0 nM
Oc1ccc2c(c1)O[C@@H](c1ccc(OCCN3CCCCCC3)cc1)C1=C2CCOc2ccccc21 CHEMBL1087418 IC50 4.0 nM
Oc1ccc(/C(=N\c2ccc(Cl)cc2)c2ccc(O)cc2O)cc1 CHEMBL3234632 EC50 4.0 nM
COc1ccc2c(c1)CCCC(c1ccccc1)=C2c1ccc(O)cc1 CHEMBL3290286 EC50 4.0 nM
CC/C(=C(\c1ccc2[nH]ncc2c1)c1ccc(/C=C/C(=O)O)cc1OC)c1ccccc1 CHEMBL3581645 EC50 4.0 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1ccc2[nH]ncc2c1)c1ccccc1OC CHEMBL3581690 EC50 4.0 nM
Oc1ccc(-c2c(Cl)c3cc(O)ccc3n2Cc2ccc(OCCN3CCCC3)cc2)cc1 CHEMBL3657166 IC50 4.0 nM
Cc1ccccc1-c1sc2cc(O)ccc2c1Oc1ccc(/C=C/C(=O)O)cc1 CHEMBL4091541 IC50 4.0 nM
Cc1cc(F)ccc1-c1sc2cc(O)ccc2c1Oc1ccc(/C=C/C(=O)O)cc1 CHEMBL4101673 IC50 4.0 nM
COc1cc(/C=C/c2ccc(OS(=O)(=O)C3CC4OC3C(c3ccc(O)cc3)=C4c3ccc(O)cc3)cc2)cc(OC)c1 CHEMBL4206281 EC50 4.0 nM
CC(CO)C(=O)N1[C@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)c2[nH]c3ccccc3c2C[C@H]1C CHEMBL4866772 DC50 4.0 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1C(=O)C1COC1 CHEMBL4870908 DC50 4.0 nM
CN1C(=O)N(CCN(CCO)CCO)C(c2ccc(C(F)(F)F)cc2)C2=C1c1ccccc1C2=O CHEMBL5198631 IC50 4.0 nM
CCC(=C(c1ccc(O)cc1)c1ccc(/C=C/C(=O)NCCCNC(=O)CCCn2c(=S)[nH]c3ccccc3c2=O)cc1)c1ccccc1 CHEMBL5094443 IC50 4.01 nM
Oc1ccc(-c2cc3ccc(O)cc3s2)cc1 CHEMBL431698 Ki 4.1 nM
O=C(O)/C=C/c1ccc(C2=C(c3ccc(O)cc3)CCSc3cc(F)ccc32)cc1 CHEMBL4224880 IC50 4.1 nM
O=C(O)/C=C/c1ccc(/C(=C(\c2ncc(C(F)(F)F)cc2Cl)C2CCC2)c2ccc(N3CCOCC3)cc2)cc1 CHEMBL4554587 EC50 4.1 nM
C[C@]12CC[C@@H]3c4ccc(B(O)O)cc4C[C@@H](CCCCCCCCC[S+]([O-])CCCC(F)(F)C(F)(F)F)[C@H]3[C@@H]1CC[C@@H]2O CHEMBL4526356 IC50 4.1 nM
CCC(=C(c1ccc(O)cc1)c1ccc(/C=C/C(=O)NCCCNC(=O)CCc2nc3ccc(OC)cc3[nH]2)cc1)c1ccccc1 CHEMBL5071793 IC50 4.11 nM
NC(=O)c1ccc(C2=C(c3ccc(O)cc3)Cc3cc(O)ccc32)cc1 CHEMBL198499 Ki 4.2 nM
Oc1ccc2c(c1)OCCC1=C2[C@H](c2ccc(OCCN3CCCCC3)cc2)Oc2ccccc21 CHEMBL1087426 IC50 4.2 nM
COc1ccc2c(c1)OCCC1=C2[C@H](c2ccc(OCCN3CCCCC3)cc2)Oc2cc(O)ccc21 CHEMBL1088344 IC50 4.2 nM
O=C(O)/C=C/c1ccc(Oc2c(-c3ccccc3C(F)F)sc3cc(O)ccc23)cc1 CHEMBL4091898 IC50 4.2 nM
N#Cc1ccc(/C(=C(\c2ccc(/C=C/C(=O)O)cc2)c2ccc(N3CCOCC3)cc2)C2CCC2)c(Cl)c1 CHEMBL4561552 EC50 4.2 nM
CCC(=C(c1ccc(O)cc1)c1ccc(/C=C/C(=O)NCCCNC(=O)c2ccc(N3CCN(C(=O)CCCCCCCn4c(=S)[nH]c5ccccc5c4=O)CC3)cc2)cc1)c1ccccc1 CHEMBL5083251 IC50 4.23 nM
Oc1ccc(C2=Cc3cc(O)ccc3C23Cc2ccccc2C3)cc1 CHEMBL281499 IC50 4.3 nM
Oc1ccc(C2=C(c3ccccc3)c3ccc(O)cc3C2)cc1 CHEMBL48352 EC50 4.3 nM
N#Cc1cc(Cl)ccc1/C(=C(\c1ccc(/C=C/C(=O)O)cc1)c1ccc2nccn2c1)C1CCC1 CHEMBL4531957 EC50 4.3 nM
Oc1ccc([C@H]2Oc3ccc(O)cc3[C@H]3CCC[C@H]32)cc1 CHEMBL216355 Ki 4.34 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3O[C@H]2c2ccc(N3CCNCC3)cc2)cc1 CHEMBL332625 IC50 4.4 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(/C=C/C(=O)O)cc2F)N1CC1(C(F)(F)F)CC1 CHEMBL5090545 EC50 4.48 nM
CC1(c2ccc(OCCN3CCCCC3)cc2)c2ccc(O)cc2CCN1c1cccc(Cl)c1 CHEMBL103305 pIC50(uM) 4.498 nM
Oc1ccc2c(c1)OCCC1=C2[C@H](c2ccc(OCCN3CCCCCC3)cc2)Oc2ccccc21 CHEMBL1087297 IC50 4.5 nM
Cc1ncsc1-c1ccc([C@@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H](NC(=O)COCCOCc2cn(CCOc3ccc(N(Cc4cccc(O)c4Cl)CC4(c5ccccc5F)CCCC4)cc3)nn2)C(C)(C)C)cc1 CHEMBL4870873 DC50 4.5 nM
O=C(O)/C=C/c1ccc(Cc2c(-c3ccc(C(F)(F)F)cc3)c(=O)oc3cc(O)ccc23)cc1 CHEMBL3427391 IC50 4.6 nM
CCC(C)c1ccc(N2CCc3cc(O)ccc3C2(C)c2ccc(/C=C/C(=O)O)cc2)cc1 CHEMBL4090556 IC50 4.6 nM
CCC(=C(c1ccc(O)cc1)c1ccc(/C=C/C(=O)NCCCNC(=O)c2ccc(N3CCN(C(=O)CCCn4c(=S)[nH]c5ccccc5c4=O)CC3)cc2)cc1)c1ccccc1 CHEMBL5094584 IC50 4.63 nM
COc1cc(/C=C/C(=O)O)cc(OC)c1[C@@H]1c2[nH]c3ccccc3c2C[C@@H](C)N1CC(C)(C)F CHEMBL5077476 EC50 4.67 nM
Oc1ccc2c(c1)CCN(Cc1ccccc1)C2c1ccc(OCCN2CCCC2)cc1 CHEMBL94280 IC50 4.7 nM
CCc1c(O)ccc2c1O[C@H](c1ccc(OCCN3CCCCC3)cc1)[C@H](c1ccc(O)cc1)S2 CHEMBL420068 IC50 4.7 nM
O=C(O)/C=C/c1ccc(C2c3ccc(O)cc3CCN2c2ccccc2)cc1 CHEMBL3775344 IC50 4.7 nM
O=C(Nc1ccc2cc[nH]c2c1)c1ccc(Br)cc1 CHEMBL4468912 IC50 4.71 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc2ccccc2[nH]1)c1cccc(OC(F)(F)F)c1 CHEMBL4742354 IC50 4.71 nM
O=C1CCC(=O)N1CCOc1ccc([C@H]2Oc3cc(O)ccc3C3=C2c2ccc(O)cc2OCC3)cc1 CHEMBL1083194 IC50 4.8 nM
COC(=O)COc1ccc(C2Oc3cc(O)ccc3C3=C2c2ccc(O)cc2OCC3)cc1 CHEMBL1085161 IC50 4.8 nM
CCCCCCCCCCCCCCCCNCCOc1ccc(/C(=C(/CC)c2ccccc2)c2ccc(O)cc2)cc1 CHEMBL3586193 IC50 4.8 nM
O=C(O)/C=C/c1ccc(/C(=C(\c2ccc(C(F)(F)F)cc2Cl)C2CCC2)c2ccc(-c3cn[nH]c3)cc2)cc1 CHEMBL4467689 EC50 4.8 nM
C[C@H](CCc1ccc(O)cc1)NC(=O)Cc1c(-c2ccccc2)n(Cc2ccc(OCCCCN3CCCCC3)cc2)c2ccccc12 CHEMBL396119 IC50 4.9 nM
C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1[C@@H](O)[C@@H](O)[C@@H]2O CHEMBL1230314 Ki 4.9 nM
CCCCCCCCCCCCNCCOc1ccc(C(CCC)(CCC)c2ccc(O)c(C)c2)cc1C CHEMBL4161714 IC50 4.9 nM
CCCCCCCCCCNCCOc1ccc(C(CCC)(CCC)c2ccc(O)c(C)c2)cc1C CHEMBL4168979 IC50 4.9 nM
CC(=O)O[C@H]1CC[C@H]2[C@@H]3[C@H](Sc4ccc(Br)cc4)C(=O)c4cc(O)ccc4[C@H]3CC[C@]12C CHEMBL1627355 EC50 5.0 nM
Oc1ccc([C@H]2Sc3cc(O)ccc3S[C@H]2c2ccc(OCCN3CCCCC3)c(Br)c2)cc1 CHEMBL124482 IC50 5.0 nM
CCCN(c1c(CC)cccc1CC)S(=O)(=O)c1ccc(O)c(C)c1 CHEMBL202472 IC50 5.0 nM
CCN(CC)CCOc1ccc([C@H]2Oc3ccccc3C3=C2c2ccc(O)cc2OCC3)cc1 CHEMBL1084128 IC50 5.0 nM
CCN(CC)CCOc1ccc([C@H]2Oc3cc(F)ccc3C3=C2c2ccc(O)cc2OCC3)cc1 CHEMBL1088629 IC50 5.0 nM
Oc1ccc2c(c1)OCCC1=C2[C@H](c2ccc(OCCN3CCCCCC3)cc2)Oc2cc(F)ccc21 CHEMBL1082528 IC50 5.0 nM
Cc1cccc(N=C(c2ccc(O)cc2)c2ccc(O)cc2)c1 CHEMBL3234615 EC50 5.0 nM
O=S(=O)(Oc1ccc(F)cc1)C1CC2OC1C(c1ccc(/C=C/c3cc(O)cc(O)c3)cc1)=C2c1ccc(O)cc1 CHEMBL4216877 IC50 5.0 nM
CC(C)=CCc1c(O)cc(O)c2c1O[C@H](c1ccc(O)cc1)CC2=O CHEMBL376915 EC50 5.0 nM
N#Cc1cc(Cl)ccc1/C(=C(\c1ccc(/C=C/C(=O)O)cc1)c1ccc(N2CCOCC2)cc1)C1CCC1 CHEMBL4457003 EC50 5.0 nM
C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@]2(O)c1cn(-c2ccccc2)nn1 CHEMBL4785948 EC50 5.0 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)N1C(=O)CC1CC1 CHEMBL4872508 DC50 5.0 nM
C[C@@H]1Cc2c(c(F)cc3[nH]ncc23)[C@@H](c2ccc(NC3CN(CCCF)C3)cn2)N1CC(F)(F)F CHEMBL4745941 pIC50 5.012 nM
Cc1cc(OCCNCCCF)cc([C@@H]2c3[nH]c4ccccc4c3C[C@@H](C)N2CC(F)(F)F)c1 CHEMBL5407684 pIC50 5.012 nM
Cc1cc(O)ccc1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(OCCN2CC(CF)C2)cc1 CHEMBL4564385 pIC50 5.129 nM
C[C@H](c1ccc(O)cc1)[C@@H](C#N)c1ccc(O)cc1 CHEMBL134938 EC50 5.2 nM
O=S(=O)(c1ccccc1)N1CCc2cc(O)ccc2C1c1ccc(OCCN2CCCC2)cc1 CHEMBL420244 IC50 5.2 nM
CC(C)c1ccc(N2CCc3cc(O)ccc3C2(C)c2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL100231 IC50 5.2 nM
O=C1C(c2ccc(O)cc2)=C(Br)c2cc(O)ccc21 CHEMBL363872 IC50 5.2 nM
O=C(c1ccc(C(F)(F)F)cc1)c1sc2cc(O)ccc2c1-c1ccc(F)cc1 CHEMBL3765211 EC50 5.2 nM
Cc1cc(F)ccc1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(OC2CN(CCCF)C2)cc1 CHEMBL4538085 IC50 5.2 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(OC)ccc4[C@H]3CC[C@@]21C CHEMBL1201151 Ki 5.223 nM
Cc1cc(O)cc2c1O[C@H](c1ccc(OCCN3CCCCC3)cc1)[C@H](c1ccc(O)cc1)S2 CHEMBL327471 IC50 5.3 nM
Oc1ccc([C@@H]2Sc3cc(O)cc(Cl)c3O[C@@H]2c2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL441457 IC50 5.3 nM
C[C@]12C[C@H](c3ccc(OCCCCCS(=O)(=O)C(F)(F)C(F)(F)F)cc3)[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@H]2O CHEMBL2036561 Ki 5.3 nM
C#Cc1ccc(C(=O)c2sc3cc(O)ccc3c2-c2ccc(F)cc2)cc1 CHEMBL3763811 EC50 5.3 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2cnc(N3CCC(CN4CCOC5(CC4)CCN(c4ccc6c(c4)CN(C4CCC(=O)NC4=O)C6=O)CC5)CC3)nc2)N1CC(C)(C)F CHEMBL4800591 IC50 5.3 nM
Cc1ncsc1-c1ccc(CNC(=O)N2C[C@H](O)CC2C(=O)[C@H](NC(=O)C2(F)CC2)C(C)(C)C)c(OCCOCc2cn(CCOc3ccc(Cn4c(-c5ccc(O)cc5)c(C)c5cc(O)ccc54)cc3)nn2)c1 CHEMBL4873959 IC50 5.3 nM
CCC(=C(c1ccc(O)cc1)c1ccc(/C=C/C(=O)NCCN)cc1)c1ccccc1 CHEMBL5094545 IC50 5.3 nM
CC/C(=C(/c1ccc(O)cc1)c1ccc(/C=C/C(=O)NCCN)cc1)c1ccccc1 CHEMBL4793264 IC50 5.33 nM
CCCCN1[C@H](c2c(F)cc(/C=C/C(=O)O)cc2F)c2[nH]c3ccccc3c2C[C@H]1C CHEMBL5078142 EC50 5.39 nM
Oc1ccc([C@@H]2Sc3cc(O)c(Cl)cc3O[C@@H]2c2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL90072 IC50 5.4 nM
CC(C)N(CCOc1ccc([C@H]2Oc3cc(O)ccc3C3=C2c2ccc(O)cc2OCC3)cc1)C(C)C CHEMBL1085669 IC50 5.4 nM
Cc1ncccc1-c1sc2cc(O)ccc2c1Oc1ccc(/C=C/C(=O)O)cc1 CHEMBL4091321 IC50 5.4 nM
CC(C)CN1[C@H](C)Cc2cc(O)ccc2[C@@]1(C)c1ccc(/C=C/C(=O)O)cc1 CHEMBL3775242 IC50 5.5 nM
Cc1c(-c2ccc(O)c(F)c2)n(Cc2ccc(OCCN3CCCCC3)cc2)c2ccc(O)cc12 CHEMBL3657162 IC50 5.5 nM
CCCCCc1ccc(N2CCc3cc(O)ccc3C2(C)c2ccc(/C=C/C(=O)O)cc2)cc1 CHEMBL4087804 IC50 5.5 nM
Oc1ccc(C2=C(c3ccc(OCCN4CCCC4)cc3)CCOc3cc(F)ccc32)cc1 CHEMBL472468 IC50 5.57 nM
O=S(=O)(c1cccc2ccccc12)N1CCc2cc(O)ccc2C1c1ccc(OCCN2CCCC2)cc1 CHEMBL93230 IC50 5.6 nM
CC(C)N(CCOc1ccc([C@@H]2Oc3cc(O)ccc3C3=C2c2ccc(O)cc2OCC3)cc1)C(C)C CHEMBL1085899 IC50 5.6 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2cnc(N3CCC(CN4CCN(CC5CCN(c6ccc7c(c6)CN(C6CCC(=O)NC6=O)C7=O)CC5)CC4)CC3)nc2)N1CC(C)(C)F CHEMBL4747484 IC50 5.6 nM
CC1=C(c2ccc(S(C)(=O)=O)cc2)C(c2ccc(OC[C@H](C)N3CC[C@@H](C)C3)cc2)Oc2ccc(O)cc21 CHEMBL4173984 IC50 5.7 nM
CC1=C(c2ccc(F)cc2)[C@H](c2ccc(OCCN3CC(CF)C3)cc2)Oc2cc3cn[nH]c3cc21 CHEMBL4460089 IC50 5.7 nM
CC/C(=C(/CC)c1ccc(OCCCC(=O)NCc2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)cc1)c1ccc(O)cc1 CHEMBL22486 Kd 5.8 nM
Oc1ccc2c3c(ccc2c1)-c1cc(F)cc(F)c1O[C@H]3c1ccc(OCCN2CCCCC2)cc1 CHEMBL559366 Ki 5.8 nM
Oc1ccc2c(c1)OCCC1=C2[C@@H](c2ccc(OCCN3CCCCC3)cc2)Oc2ccccc21 CHEMBL1087298 IC50 5.8 nM
COc1ccc2c(c1)OCCC1=C2[C@@H](c2ccc(OCCN3CCCCC3)cc2)Oc2cc(O)ccc21 CHEMBL1088343 IC50 5.8 nM
Cc1cc(F)ccc1-c1c(-c2ccc(/C=C/C(=O)O)cc2)c2ccc(O)cc2oc1=O CHEMBL3427400 IC50 5.8 nM
COC[C@H](C)CN1[C@H](c2ccc(/C=C/C(=O)O)cc2)c2ccc(O)cc2C[C@H]1C CHEMBL3775329 IC50 5.8 nM
Clc1ccc(Cn2nnc(-c3cn(Cc4ccccc4)c4ccccc34)n2)cc1Cl CHEMBL5430117 IC50 5.826 nM
Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(OCCN2CC[C@@H](CF)C2)cc1 CHEMBL4440649 pIC50 5.888 nM
Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(OC2CN(C3CC3)C2)cc1 CHEMBL4436415 pIC50 5.888 nM
O=C(/C=C/c1ccc(N2CCc3cc(O)ccc3C2c2ccccc2)cc1)N1CCOCC1 CHEMBL93586 IC50 5.9 nM
O=C(O)/C=C/c1ccc(Cc2c(-c3cccc(OC(F)(F)F)c3)c(=O)oc3cc(O)ccc23)cc1 CHEMBL3427388 IC50 5.9 nM
O=C(O)/C=C/c1ccc(/C(=C(\c2ccccc2)C2CCC2)c2ccc3scnc3c2)cc1 CHEMBL4460153 EC50 5.9 nM
CCCC(CCC)(c1ccc(O)cc1)c1ccc(O)cc1 CHEMBL2403361 IC50 5.9 nM
Oc1ccc2c(-c3cccc4c(O)cccc34)noc2c1 CHEMBL188051 IC50 6.0 nM
CC1=C(c2ccc(O)cc2)C(=O)c2ccc(O)cc21 CHEMBL370037 IC50 6.0 nM
Oc1ccc2c(c1)sc1c3cc(O)ccc3n(Cc3ccc(OCCN4CCCC4)cc3)c21 CHEMBL370849 IC50 6.0 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cccc2[nH]ncc12)c1ccccc1 CHEMBL3580674 EC50 6.0 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)c(C)c1)c1ccc2[nH]ncc2c1)c1ccccc1 CHEMBL3581644 EC50 6.0 nM
C[C@H](O)c1ccccc1-c1sc2cc(O)ccc2c1Oc1ccc(/C=C/C(=O)O)cc1 CHEMBL4086984 IC50 6.0 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCc2cn(CCOc3ccc(Cn4c(-c5ccc(O)cc5)c(C)c5cc(O)ccc54)cc3)nn2)C(C)(C)C)cc1 CHEMBL4856006 IC50 6.0 nM
O=C(c1ccc(O)c(F)c1)N(c1ccc(O)cc1)c1ccc(O)cc1 CHEMBL3645267 Ki 6.06 nM
Oc1ccc([C@H]2Oc3ccc(O)cc3[C@H]3CCCCC[C@H]32)cc1 CHEMBL234463 Ki 6.11 nM
Oc1ccc2c(c1)S[C@@H](c1ccccc1)[C@@H](c1ccc(OCCN3CCCCC3)cc1)O2 CHEMBL71585 IC50 6.2 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCCC(=O)N(C)C4CC[C@@]5(C)[C@@H](C4)C[C@@H](O)[C@@H]4[C@@H]5C[C@H](O)[C@]5(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]45)cc3)C[C@@]21C CHEMBL408376 Ki 6.2 nM
O=C1CCC(=O)N1CCOc1ccc([C@@H]2Oc3cc(O)ccc3C3=C2c2ccc(O)cc2OCC3)cc1 CHEMBL1088337 IC50 6.2 nM
N#C[C@@H](Cc1ccc(O)cc1)c1ccc(O)cc1 CHEMBL1950809 EC50 6.2 nM
Oc1ccc(Oc2c(-c3ccc(F)cc3)sc3cc(O)ccc23)cc1 CHEMBL3765583 EC50 6.2 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(N3CCC(F)(F)CC3)cc2F)N1CC(C)(C)F CHEMBL5080148 EC50 6.27 nM
C[C@H](CN1CCCC1)Oc1ccc([C@@H]2Oc3ccc(O)cc3S[C@@H]2c2ccc(O)cc2)cc1 CHEMBL183044 IC50 6.3 nM
Oc1ccc2c(c1)O[C@@H](c1ccc(OCCN3CCCCC3)cc1)C1=C2CCOc2ccccc21 CHEMBL1086652 IC50 6.3 nM
COc1ccc2c(c1)O[C@@H](c1ccc(OCCN3CCCCC3)cc1)C1=C2CCOc2cc(O)ccc21 CHEMBL1082864 IC50 6.3 nM
CC(C)CN1CCc2c(ccc3[nH]ncc23)[C@H]1c1ccc(/C=C/C(=O)O)cc1 CHEMBL4515274 pIC50 6.31 nM
CCC(c1ccc(O)cc1)C1CCc2cc(O)ccc21 CHEMBL4740602 EC50 6.33 nM
O=C(/C=C/c1ccc(C(=C2CCCCC2)c2ccc(O)cc2)cc1)NCCNC(=O)/C=C/c1ccc(C(=C2CCCCC2)c2ccc(O)cc2)cc1 CHEMBL4784145 IC50 6.43 nM
Oc1ccc(C2=C(c3ccc(OCCN4CCCCC4)cc3)c3ccc(F)cc3OCC2)cc1 CHEMBL511971 IC50 6.5 nM
CC(Cc1ccc(O)cc1)c1ccc(O)cc1 CHEMBL554507 EC50 6.5 nM
C[C@H](CCc1ccc(O)cc1)NC(=O)Cc1c(-c2ccccc2)[nH]c2ccc(OCCCCCN3CCCCC3)cc12 CHEMBL241256 IC50 6.6 nM
CC(F)(c1cc(F)ccc1-c1sc2c(ccc3[nH]ncc32)c1Oc1ccc(NC2CN(CCCF)C2)cc1)C(F)(F)F CHEMBL5208566 EC50 6.6 nM
Cc1cc(O)ccc1CC(C#N)c1ccc(O)cc1 CHEMBL135695 EC50 6.7 nM
Oc1ccc2c(c1)CCN(c1ccccc1)C2Cc1ccccc1 CHEMBL315866 IC50 6.7 nM
Oc1ccc([C@@H]2Cc3ccc(O)cc3O[C@@H]2c2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL30439 IC50 6.7 nM
COc1ccc2c(c1)OCCC(c1ccc(O)cc1)=C2c1ccc(OCCN2CCC2)cc1 CHEMBL511269 IC50 6.7 nM
Oc1ccc(-c2cc3cc(O)cc(Cl)c3o2)cc1 CHEMBL184448 IC50 6.8 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(NC3(C(=O)O)CC3)cc2F)N1CC(C)(C)F CHEMBL5088727 EC50 6.85 nM
CC[C@H](C)[C@@H]1NC(=O)[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)CCSC[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(N)=O)NC(=O)[C@H](CC(C)C)NC1=O CHEMBL4250447 Ki 6.9 nM
CCOC(=O)C1(C#N)Cc2ccc([C@]3(O)CC[C@H]4[C@@H]5CCc6cc(O)ccc6[C@H]5CC[C@@]43C)cc2C1 CHEMBL1098710 pEC50 6.918 nM
CC(C)[C@H]1Sc2cc(O)ccc2O[C@H]1c1ccc(OCCN2CCCCC2)cc1 CHEMBL313825 IC50 7.0 nM
C[C@]12CC[C@@H]3c4ccc(O)cc4C(O)[C@@H](Sc4ccc(Br)cc4)[C@H]3[C@@H]1CC[C@@H]2O CHEMBL1627353 EC50 7.0 nM
CC/C(=C(\c1ccccc1)c1ccc(O)cc1)c1ccccc1 CHEMBL50995 IC50 7.0 nM
Oc1ccc(C2=C(c3ccc(O)cc3)c3ccc(O)cc3C2)cc1 CHEMBL26865 EC50 7.0 nM
CCCN(c1c(C)cccc1CC)S(=O)(=O)c1ccc(O)c(C)c1 CHEMBL371637 IC50 7.0 nM
Oc1ccc(-c2nn3c(C(F)(F)F)cc(C(F)(F)F)nc3c2-c2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL218220 Ki 7.0 nM
CCN(CC)CCOc1ccc([C@@H]2Oc3cc(F)ccc3C3=C2c2ccc(O)cc2OCC3)cc1 CHEMBL1084120 IC50 7.0 nM
Cc1ccccc1N=C(c1ccc(O)cc1)c1ccc(O)cc1 CHEMBL3234614 EC50 7.0 nM
Oc1ccc(/C(=N\c2ccccc2)c2ccc(O)cc2O)cc1 CHEMBL3234626 EC50 7.0 nM
Oc1ccc(/N=C(\c2ccc(O)cc2)c2ccc(O)cc2O)cc1 CHEMBL3234637 EC50 7.0 nM
CC(C)CN1[C@H](c2ccc(/C=C/C(=O)O)cc2)c2ccc(O)cc2CC1(C)C CHEMBL3775540 IC50 7.0 nM
CC1(c2ccc(/C=C/C(=O)O)cc2)c2ccc(O)cc2CCN1c1ccc(F)cc1 CHEMBL4063001 IC50 7.0 nM
CC(C)CCCCCOC(=O)/C=C/c1ccc(C(=C2C3CC4CC(C3)CC2C4)c2ccc(O)cc2)cc1 CHEMBL4072205 Ki 7.1 nM
C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@]2(O)c1cn(Cc2ccccc2)nn1 CHEMBL4778702 EC50 7.1 nM
CN1C(=O)NC(c2ccc(OCCN(CCO)CCO)cc2)C2=C1c1ccccc1C2=O CHEMBL5176445 IC50 7.1 nM
Cc1cccc(C(=O)N(c2ccc(O)cc2)c2ccc(O)cc2)c1C CHEMBL3645265 Ki 7.13 nM
Oc1ccc([C@@H]2Oc3ccc(O)cc3[C@@H]3C[C@@H](C(F)(F)F)C[C@@H]32)cc1 CHEMBL391532 Ki 7.2 nM
CN(Cc1cccc(O)c1Cl)CC1(c2ccccc2F)CCCC1 CHEMBL4855559 IC50 7.2 nM
OCCC1CCN(CCOc2ccc([C@@H]3Oc4ccc(O)cc4S[C@@H]3c3ccc(O)cc3)cc2)CC1 CHEMBL365484 IC50 7.3 nM
CC(=O)c1ccc(C2=C(c3ccc(O)cc3)Cc3cc(O)ccc32)cc1 CHEMBL370403 Ki 7.3 nM
CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(C(=O)c2cccc(OCCOCc3cn(CCOc4ccc(Cn5c(-c6ccc(O)cc6)c(C)c6cc(O)ccc65)cc4)nn3)c2)cs1)C1CCCCC1 CHEMBL4850845 IC50 7.3 nM
Oc1ccc2c(c1)S[C@H](Cc1ccccc1)[C@H](c1ccc(OCCN3CCCCC3)cc1)O2 CHEMBL85536 IC50 7.4 nM
Cc1cc(F)ccc1-c1c(Oc2ccc(/C=C/C(=O)O)cc2)c2cc(F)c(O)cc2oc1=O CHEMBL3427406 IC50 7.4 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1ccc(-c2cncs2)cc1)c1ccccc1 CHEMBL4436368 EC50 7.4 nM
Oc1ccc2c(c1)S[C@H](C1CCCCCC1)[C@H](c1ccc(OCCN3CCCCC3)cc1)O2 CHEMBL316132 IC50 7.5 nM
COC[C@H](C)CN1[C@H](c2c(F)cc(/C=C/C(=O)O)cc2F)c2ccc(O)cc2CC1(C)C CHEMBL3774944 IC50 7.5 nM
CCCC(CCC)(c1ccc(O)c(C)c1)c1ccc(NC)c(C)c1 CHEMBL4459248 IC50 7.5 nM
COc1ccc(S(=O)(=O)Nc2ccc3cc[nH]c3c2)cc1 CHEMBL4444460 IC50 7.53 nM
CC(=O)Oc1ccc(/C(=C(/C)c2ccccc2)c2ccc(OCCN3CCCC3)cc2)cc1 CHEMBL3775434 IC50 7.7 nM
Oc1ccc(-c2sc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1 CHEMBL226268 IC50 7.8 nM
C[C@H](CCc1ccc(O)cc1)NC(=O)Cc1c(-c2ccccc2)n(Cc2ccc(OCCCN3CCCCC3)cc2)c2ccccc12 CHEMBL238961 IC50 7.8 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(N3CCC(C(=O)O)CC3)cc2F)N1CC(C)(C)F CHEMBL5087752 EC50 7.8 nM
CCc1nc2cc(O)ccc2c(Oc2ccc(OCCN(C)C)cc2)c1-c1ccccc1 CHEMBL195080 Log Ki 7.943 nM
C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2cc(F)cc(OCCNCCCF)c2)N1CC(F)(F)F CHEMBL5424508 pIC50 7.943 nM
C[C@]12CCc3c(ccc4cc(O)ccc34)[C@@H]1CC[C@H]2O CHEMBL135236 Ki 8.0 nM
CN(C)C(=O)/C=C/c1ccc(N2CCc3cc(O)ccc3C2c2ccccc2)cc1 CHEMBL93391 IC50 8.0 nM
Oc1ccc2cc(-c3noc4cc(O)ccc34)ccc2c1 CHEMBL187105 IC50 8.0 nM
C[C@H](CCc1ccc(O)cc1)NC(=O)Cc1c(-c2ccccc2)[nH]c2cc(OCCN3CCCCC3)ccc12 CHEMBL241303 IC50 8.0 nM
COc1ccc([C@H]2[C@H](C(O)c3ccc(O)cc3)C(=O)N2c2cc(OC)c(OC)c(OC)c2)cc1 CHEMBL3360850 IC50 8.0 nM
CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1ccc2[nH]ncc2c1)c1ccncc1C CHEMBL3581678 EC50 8.0 nM
O=C(O)c1ccc2c(c1)CCCC(c1ccc(SC(F)(F)F)cc1)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4524318 EC50 8.0 nM
O=C(O)c1ccc2c(c1)CCCC(c1ccc(Cl)cc1)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1 CHEMBL4513462 EC50 8.0 nM
Cc1ccccc1C(OC(c1ccccc1C)c1ccccc1C)c1ccccc1C CHEMBL4763747 IC50 8.0 nM
CC(=O)N1[C@H](c2c(F)cc(OCCN3CC(CF)C3)cc2F)c2[nH]c3ccccc3c2C[C@H]1C CHEMBL4867408 DC50 8.0 nM
Oc1cccc(CN(CC2(c3ccccc3F)CCCC2)c2ccc(OCCN3CCCCC3)cc2)c1Cl CHEMBL4851230 IC50 8.0 nM
O=C(O)/C=C/c1ccc(Cc2c(-c3ccccc3)c(=O)oc3cc(O)ccc23)cc1 CHEMBL3427385 IC50 8.1 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCc2cn(CCOc3ccc(Cn4c(-c5ccc(O)cc5)c(C)c5cc(O)ccc54)cc3)nn2)C(C)(C)C)cc1 CHEMBL4851860 IC50 8.1 nM
O=C(c1ccc(O)cc1)c1sc2cc(O)ccc2c1Oc1ccc(OCCN2CC(CF)C2)cc1 CHEMBL4464171 pIC50 8.128 nM
O=C(Nc1ccc2cc[nH]c2c1)c1ccc(C(F)(F)F)cc1 CHEMBL4555331 IC50 8.15 nM
CC[C@@]12CCC(=O)C(C(F)(F)F)=C1c1ccc3[nH]nc(F)c3c1C2 CHEMBL385680 EC50 8.3 nM
Oc1ccc([C@@H]2Oc3ccc(O)cc3[C@@H]3CC(F)(F)C[C@@H]32)cc1 CHEMBL236718 Ki 8.3 nM
Oc1ccc(C2=C(c3ccc(OCCN4CCCC4)cc3)c3ccc(O)cc3OCC2)cc1 CHEMBL469511 IC50 8.4 nM
O/N=C/c1c(O)ccc(-c2ccc(O)c(F)c2)c1Cl CHEMBL1782958 EC50 8.4 nM
Oc1ccc(-c2noc(C(F)(F)F)c2-c2ccccc2)cc1 CHEMBL200021 IC50 8.5 nM
CCc1ccc2c(c1)C(c1ccc(OCCN3CCCCC3)cc1)Cc1cc(O)cc(C)c1-2 CHEMBL30996 Ki 8.69 nM
CN1CCN(CCOc2ccc([C@H]3Oc4cc(O)ccc4C4=C3c3ccc(O)cc3OCC4)cc2)CC1 CHEMBL1084922 IC50 8.7 nM
c1ccc(C2=C(c3ccc(OCCN4CCC4)cc3)c3ccccc3OCC2)cc1 CHEMBL513397 IC50 8.77 nM
Oc1ccc2c(c1)S[C@H](c1cccs1)[C@H](c1ccc(OCCN3CCCCC3)cc1)O2 CHEMBL83623 IC50 8.8 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCCOC4CC[C@@]5(C)[C@@H](C4)C[C@@H](O)[C@@H]4[C@@H]5C[C@H](O)[C@]5(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]45)cc3)C[C@@]21C CHEMBL415621 Ki 8.8 nM
CC/C(=C(\c1ccc(O)cc1)c1cccc(OCCCN(C)C)c1)c1ccccc1 CHEMBL5078348 IC50 8.8 nM
Oc1ccc(C(=C(CC(F)(F)F)c2ccccc2)c2ccc(O)cc2)cc1 CHEMBL357283 IC50 9.0 nM
O=C1C(c2ccc(O)cc2)=C(c2ccccc2)c2ccc(O)cc21 CHEMBL192586 IC50 9.0 nM
CCN(CC)CCOc1ccc([C@@H]2Oc3ccccc3C3=C2c2ccc(O)cc2OCC3)cc1 CHEMBL1084129 IC50 9.0 nM
COc1ccc2c(c1)O[C@H](c1ccc(OCCN3CCCCC3)cc1)C1=C2CCOc2cc(O)ccc21 CHEMBL1088483 IC50 9.0 nM
Oc1ccc(-c2cc(-c3ccc(O)cc3Cl)c(-c3ccc(O)cc3Cl)s2)c(Cl)c1 CHEMBL2332582 EC50 9.0 nM
Oc1ccc(/C(=N\c2ccc(Br)cc2)c2ccc(O)cc2O)cc1 CHEMBL3234635 EC50 9.0 nM
O=C(O)/C=C/c1ccc(Cc2c(-c3ccc(F)cc3)c(=O)oc3cc(O)ccc23)cc1 CHEMBL3427389 IC50 9.0 nM
O=C(c1ccc2ccccc2c1)N(c1ccc(O)cc1)c1ccc(O)cc1 CHEMBL3645266 Ki 9.0 nM
CCc1ccc2c(c1)C(c1ccc(OCCN3CCOCC3)cc1)Cc1cc(O)cc(C)c1-2 CHEMBL3815076 IC50 9.0 nM
Cc1c(-c2cccc(O)c2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12 CHEMBL3657161 IC50 9.0 nM
C[C@H](CCc1ccc(O)cc1)NC(=O)Cc1c(-c2ccccc2)[nH]c2cc(OCCCN3CCCC3)ccc12 CHEMBL393982 IC50 9.1 nM
Oc1ccc2c(c1)CCN(Cc1ccc3c(c1)OCO3)C2c1ccc(OCCN2CCCC2)cc1 CHEMBL92900 IC50 9.2 nM
Cc1cc(O)ccc1C1=C(c2ccc(O)cc2C)[C@H]2[C@@H](S(=O)(=O)Oc3ccc(O)cc3)C[C@@H]1[S+]2[O-] CHEMBL2031528 EC50 9.2 nM
CCc1c(-c2ccc(O)cc2)c2ccc3cccc1n32 CHEMBL420017 IC50 9.5 nM
O=c1c(-c2ccc(O)cc2)coc2cc(O)cc(O)c12 CHEMBL44 IC50 9.7 nM
CC1=C(c2cccc(O)c2)[C@@H](c2ccc(OC[C@H](C)N3CC[C@@H](C)C3)cc2)Oc2ccc(O)cc21 CHEMBL4159656 IC50 9.7 nM
Cc1cc(F)ccc1-c1c(N(C)c2ccc(/C=C/C(=O)O)cc2)c2ccc(O)cc2oc1=O CHEMBL3427404 IC50 9.9 nM