N#Cc1cccc(OC(=O)N2CCC(c3nc(C4=NOC(c5ccccc5)C4)cs3)CC2)c1 CHEMBL3797635 Ki 0.0025 nM
Cc1ccccc1OC(=O)N1CCC(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 CHEMBL3800456 Ki 0.0034 nM
O=C(Oc1ccccc1Cl)N1CCC(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 CHEMBL3797841 Ki 0.0053 nM
O=C(Oc1ccccc1)N1CCC(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 CHEMBL3798156 Ki 0.0063 nM
O=C(Oc1ccc(Cl)cc1)N1CCC(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 CHEMBL3799744 Ki 0.0072 nM
N#Cc1ccc(OC(=O)N2CCN(c3nc(C4=NOC(c5ccccc5)C4)cs3)CC2)cc1 CHEMBL3797809 Ki 0.0081 nM
COc1ccc(OC(=O)N2CCC(c3nc(C4=NOC(c5ccccc5)C4)cs3)CC2)cc1 CHEMBL3798535 IC50 0.01 nM
O=C(Oc1ccc(Cl)cc1)N1CCN(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 CHEMBL3797772 IC50 0.01 nM
N#Cc1ccc(OC(=O)N2CCC(c3nc(C4=NOC(c5ccccc5)C4)cs3)CC2)cc1 CHEMBL3798476 Ki 0.0128 nM
O=C(Oc1ccc(C(F)(F)F)cc1)N1CCN(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 CHEMBL3798355 Ki 0.0147 nM
Cc1ccc(OC(=O)N2CCC(c3nc(C4=NOC(c5ccccc5)C4)cs3)CC2)cc1 CHEMBL3800599 Ki 0.0185 nM
N#Cc1cccc(OC(=O)N2CCN(c3nc(C4=NOC(c5ccccc5)C4)cs3)CC2)c1 CHEMBL3799008 Ki 0.0185 nM
O=C(Oc1ccc([N+](=O)[O-])cc1)N1CCN(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 CHEMBL3799516 Ki 0.0185 nM
O=C(Oc1cccnc1)N1CCC(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 CHEMBL3798487 IC50 0.02 nM
O=C(Nc1cccnn1)N1CCN(c2nccc(-c3cc(F)ccc3F)n2)CC1 CHEMBL3113272 IC50(app) 0.025 nM
O=C(Oc1ccc(C(F)(F)F)cc1)N1CCC(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 CHEMBL3797226 Ki 0.0336 nM
O=C(Oc1cccc(Cl)c1)N1CCC(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 CHEMBL3797377 Ki 0.0383 nM
Cc1cccc(OC(=O)N2CCC(c3nc(C4=NOC(c5ccccc5)C4)cs3)CC2)c1 CHEMBL3798594 Ki 0.056 nM
O=C(Nc1cccnn1)N1CCN(c2nccc(-c3cccc(F)c3F)n2)CC1 CHEMBL3113271 IC50(app) 0.072 nM
O=C(Nc1cccnn1)N1CCN(c2nccc(-c3cc(F)cc(F)c3)n2)CC1 CHEMBL3113274 IC50(app) 0.08 nM
O=C(N1CCC(Oc2ccc(OCc3cccc(F)c3)cc2)CC1)n1ccnc1 CHEMBL1812722 IC50 0.093 nM
O=C(CCCCCc1ccccc1)c1nc2ncccc2o1 CHEMBL175854 Ki 0.094 nM
O=C(CCCCCCCCc1ccccc1)c1nc2ncccc2o1 CHEMBL182199 IC50 0.1 nM
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCS(=O)(=O)F CHEMBL112486 IC50 0.1 nM
O=C(Oc1ccccc1)N1CCN(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 CHEMBL3799633 Ki 0.147 nM
CCCCCCCCCCCOc1ccc(NC(=O)O/N=C/c2cccnc2)cc1 CHEMBL598764 IC50 0.15 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CC(c2ccn(Cc3ccccc3)n2)C1 CHEMBL4078217 IC50 0.16 nM
N#Cc1cnc(C(=O)CCc2ccc(-c3ccccc3)cc2)o1 CHEMBL272111 Ki 0.2 nM
CCCCCCCCCOc1ccc(NC(=O)O/N=C/c2ccc(F)cc2)cc1 CHEMBL597648 IC50 0.2 nM
NC(=O)c1cccc(-c2cccc(OC(=O)NC3CCCCC3)c2)c1 CHEMBL184238 IC50 0.24 nM
CCCCCCCCCOc1ccc(NC(=O)O/N=C/c2ccccc2)cc1 CHEMBL597430 IC50 0.25 nM
CCCCCCCCCCOc1ccc(NC(=O)O/N=C/c2ccc(F)cc2)cc1 CHEMBL596658 IC50 0.25 nM
CCCCCCCCOc1ccc(NC(=O)O/N=C/c2ccc(F)cc2)cc1 CHEMBL597647 IC50 0.27 nM
O=C(CCCCCCc1ccccc1)c1nc2ncccc2o1 CHEMBL367966 Ki 0.28 nM
O=C(CCCCCCc1ccccc1)c1nnc(-c2ccccn2)o1 CHEMBL178398 Ki 0.29 nM
O=C(CCCCCCCc1ccccc1)c1nc2ncccc2o1 CHEMBL179760 IC50 0.3 nM
O=C(CCCCc1ccccc1)c1nc2ncccc2o1 CHEMBL464186 Ki 0.3 nM
CN(C)C(=O)[C@H]1C[C@@H]1c1ccc(-c2ncn(C)c2Sc2ccc(Cl)cc2)cc1 CHEMBL2386566 IC50 0.3 nM
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCP(=O)(F)OC CHEMBL113262 IC50 0.33 nM
CCCCCCCCCCOc1ccc(NC(=O)O/N=C/c2ccccc2)cc1 CHEMBL597431 IC50 0.35 nM
CCCCCCCCCCOc1ccc(NC(=O)O/N=C/c2cccnc2)cc1 CHEMBL598558 IC50 0.35 nM
CCCCCCCCCCCCOc1ccc(NC(=O)O/N=C/c2cccnc2)cc1 CHEMBL597940 IC50 0.35 nM
COc1cccc(-c2ccc(COC3(C)CN(C#N)C3)cc2)c1 CHEMBL4641417 IC50 0.36 nM
N#Cc1cnc(C(=O)CCCCCCc2ccccc2)o1 CHEMBL220770 Ki 0.4 nM
O=C(CCCC1CCN(Cc2cccc(Oc3ccccc3)c2)CC1)c1ncco1 CHEMBL486157 IC50 0.4 nM
CCCCCCCCCCCOc1ccc(NC(=O)O/N=C/c2ccc(F)cc2)cc1 CHEMBL596659 IC50 0.4 nM
O=C(CCCCCCc1ccccc1)c1ncc(-c2ccccn2)o1 CHEMBL177577 IC50 0.4 nM
CCCCCCCCOc1ccc(NC(=O)O/N=C/c2ccccc2)cc1 CHEMBL597229 IC50 0.43 nM
Cc1onc(NC(=O)N2CCN(c3nc(-c4ccc(F)cc4F)cs3)CC2)c1C CHEMBL2326178 IC50 0.43 nM
O=C(CCc1ccc(OCc2ccccc2)cc1)c1ncc(-c2ccccn2)o1 CHEMBL427424 Ki 0.45 nM
CCCCCCCCCCCOc1ccc(NC(=O)O/N=C/c2ccccc2)cc1 CHEMBL586217 IC50 0.45 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CC(c2cc(-c3ccccc3)n(-c3ccccc3)n2)C1 CHEMBL4077745 IC50 0.49 nM
O=C(c1nnco1)[C@H]1CCc2cc(Oc3ccccc3)ccc2C1 CHEMBL1765982 Ki 0.5 nM
O=C(Nc1noc2cnccc12)N1CCN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CC1 CHEMBL2207348 IC50 0.5 nM
CNC(=O)[C@H]1C[C@@H]1c1ccc(-c2ncn(C)c2Sc2ccc(Cl)cc2)cc1 CHEMBL2386568 IC50 0.5 nM
[11CH3]n1cc(Sc2ccc(Cl)cc2)c(-c2ccc3ccc(C(N)=O)nc3c2)n1 CHEMBL2386554 IC50 0.5 nM
NC(=O)c1cccc(-c2ccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1 CHEMBL4091498 IC50 0.5 nM
N#Cc1cnc(C(=O)CCc2ccc(COc3ccccc3)cc2)o1 CHEMBL258820 Ki 0.51 nM
CCCCCCCCCCCC(=O)c1nc2ncccc2o1 CHEMBL257307 Ki 0.57 nM
O=C(CCCCCCCc1ccccc1)c1nnc(-c2ccccn2)o1 CHEMBL182206 IC50 0.6 nM
Cc1ccnc(-c2cnc(C(=O)CCCCCCc3ccccc3)o2)c1 CHEMBL219658 Ki 0.6 nM
COC(=O)c1ccnc(-c2cnc(C(=O)CCCCCCc3ccccc3)o2)c1 CHEMBL220379 IC50 0.6 nM
O=C(CCc1ccc(OCc2ccccc2)cc1)c1nc2ncccc2o1 CHEMBL410598 Ki 0.6 nM
NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1 CHEMBL4086944 IC50 0.6 nM
NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1 CHEMBL4092052 IC50 0.6 nM
NC(=O)c1cccc(-c2cccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1 CHEMBL4070196 IC50 0.6 nM
O=C(Nc1cccnc1)N1CCC(Cc2cccc(Oc3ccc(C(F)(F)F)cc3)c2)CC1 CHEMBL4204424 IC50 0.6 nM
Nc1ncc(C(=O)NC2CCC(=Cc3cccc(Oc4ccc(C(F)(F)F)cn4)c3)CC2)cn1 CHEMBL4438972 IC50 0.6 nM
NC(=O)c1ccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)cc1 CHEMBL4781803 IC50 0.6 nM
NC(=O)c1cccc(-c2cccc(OC(=O)NCc3ccc4ccccc4c3)c2)c1 CHEMBL483697 IC50 0.63 nM
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccccc1 CHEMBL3799603 IC50 0.63 nM
CCCCCCCCCOc1ccc(NC(=O)O/N=C/c2cccnc2)cc1 CHEMBL598557 IC50 0.65 nM
O=C(CCc1ccc(COc2ccccc2)cc1)c1ncc(C(F)(F)F)o1 CHEMBL405604 Ki 0.67 nM
Cc1onc(NC(=O)N2CCN(c3nc(-c4ccccc4F)cs3)CC2)c1C CHEMBL2326194 IC50 0.67 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CC(c2ccn(-c3ccc(F)c(F)c3)n2)C1 CHEMBL4097203 IC50 0.67 nM
CCCCCCCC(=O)c1nc2ncccc2o1 CHEMBL257305 Ki 0.69 nM
O=C(NC1CCC(=Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1)c1cccnc1 CHEMBL4593464 IC50 0.7 nM
O=C(Nc1cccnn1)N1CCN(c2nccc(-c3ccc(F)c(F)c3)n2)CC1 CHEMBL3113273 IC50(app) 0.72 nM
O=C(CCc1ccc(-c2ccccc2)cc1)c1ncc(-c2ccccn2)o1 CHEMBL227046 Ki 0.75 nM
CCCCCCCCCC(=O)c1nc2ncccc2o1 CHEMBL1812708 Ki 0.75 nM
O=C(CCCCCCCCc1ccccc1)c1nnc(-c2ccccn2)o1 CHEMBL361529 IC50 0.8 nM
O=C(CCCCCCc1ccccc1)c1ncc(C(F)(F)F)o1 CHEMBL373606 Ki 0.8 nM
COc1ccnc(-c2cnc(C(=O)CCCCCCc3ccccc3)o2)c1 CHEMBL220629 Ki 0.8 nM
N#Cc1ccnc(-c2cnc(C(=O)CCCCCCc3ccccc3)o2)c1 CHEMBL219633 IC50 0.8 nM
CCCCCCCCOc1ccc(NC(=O)O/N=C/c2cccnc2)cc1 CHEMBL598556 IC50 0.8 nM
[3H]C([3H])([3H])n1cnc(-c2ccc([C@H]3C[C@@H]3C(=O)N(C)C)cc2)c1Sc1ccc(Cl)cn1 CHEMBL2386571 Kd 0.8 nM
Cn1cnc(-c2ccc([C@H]3C[C@@H]3C(N)=O)cc2)c1Sc1ccc(Cl)cc1 CHEMBL2386567 IC50 0.8 nM
N#Cc1cnc(C(=O)CCc2ccc(Oc3ccccc3)cc2)o1 CHEMBL272038 Ki 0.85 nM
Cc1onc(NC(=O)N2CCN(c3nc(-c4ccc(F)cc4)cs3)CC2)c1C CHEMBL2326177 IC50 0.86 nM
COC(=O)c1cnc(C(=O)CCCCCCc2ccccc2)o1 CHEMBL220784 Ki 0.9 nM
O=C(CCCCCCc1cccc(Cl)c1)c1ncc(-c2ccccn2)o1 CHEMBL388599 Ki 0.9 nM
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1 CHEMBL4079093 IC50 0.9 nM
O=C(CCCCCCc1ccccc1)c1nc(-c2ccccn2)no1 CHEMBL469198 Ki 0.92 nM
Cc1onc(NC(=O)N2CCN(c3nc(-c4ccccc4)cs3)CC2)c1C CHEMBL2326192 IC50 0.92 nM
O=C(Nc1cnccn1)N1CCC(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 CHEMBL3799163 Ki 0.924 nM
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2[nH]cnc12 CHEMBL3798331 IC50 0.99 nM
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)c1nc2ncccc2o1 CHEMBL371831 Ki 1.0 nM
NC(=O)c1cccc(-c2cnc(C(=O)CCCCCCc3ccccc3)o2)n1 CHEMBL220614 Ki 1.0 nM
O=C(CCc1ccc(Oc2ccccc2)cc1)c1ncc(C(F)(F)F)o1 CHEMBL271792 Ki 1.0 nM
CC(C)c1cccc(CN2CCC(CCCC(=O)c3ncco3)CC2)c1 CHEMBL428874 IC50 1.0 nM
O=C(CCc1ccc(COc2ccccc2)cc1)c1ncc(-c2ccccn2)o1 CHEMBL226938 Ki 1.0 nM
CCCCCCCCCCCOc1ccc(NC(=O)Oc2ccccc2)cc1 CHEMBL597923 IC50 1.0 nM
O=C(Nc1ccccc1F)N1CCN(c2nc(-c3ccccc3)ns2)CC1 CHEMBL472535 IC50 1.0 nM
CCn1c(=O)n([C@H]2CCCN(c3nccc(-c4ccc(Cl)s4)n3)C2)c2ncccc21 CHEMBL1761301 IC50 1.0 nM
O=C(c1nnc(-c2ccccn2)o1)[C@H]1CCc2cc(Oc3ccccc3)ccc2C1 CHEMBL1765984 Ki 1.0 nM
COc1ccc(N2CCN(C(=O)n3nnc4ccc(N5CCCC5)nc43)CC2)cc1 CHEMBL1812721 IC50 1.0 nM
CCOc1ccc(-c2cc(NC[C@H](O)c3ccccc3)ncn2)cc1Cl CHEMBL1812715 IC50 1.0 nM
Cn1cnc(-c2ccc([C@H]3C[C@@H]3C(=O)NCCF)cc2)c1Sc1ccc(Cl)cc1 CHEMBL2386569 IC50 1.0 nM
CN(C)C(=O)[C@H]1C[C@@H]1c1ccc(-c2ncn(C)c2Sc2ccc(Cl)cn2)cc1 CHEMBL2386558 IC50 1.0 nM
O=C(Nc1cccnc1)N1CCN(Cc2cccc(Oc3ccc(C(F)(F)F)cc3)c2)CC1 CHEMBL3809293 IC50 1.0 nM
O=C(Nc1cccnc1)N1CCC(Cc2cccc(Oc3ccc(Cl)cn3)c2)CC1 CHEMBL3809683 IC50 1.0 nM
NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1 CHEMBL4069565 IC50 1.0 nM
COc1ccc(-c2ccc(COC3(C4CC4)CN(C#N)C3)c(F)c2)cc1F CHEMBL4633233 IC50 1.0 nM
O=C(CCCCCCc1ccccc1)c1nnn(-c2ccccn2)n1 CHEMBL467368 Ki 1.1 nM
CN(CCF)C(=O)[C@H]1C[C@@H]1c1ccc(-c2ncn(C)c2Sc2ccc(Cl)cc2)cc1 CHEMBL2386570 IC50 1.1 nM
CNC(=O)[C@H]1C[C@@H]1c1ccc(-c2ncn(C)c2Sc2ccc(Cl)cn2)cc1 CHEMBL2386562 IC50 1.1 nM
O=C(Nc1cccnn1)N1CCN(c2nccc(-c3ccc(F)cc3F)n2)CC1 CHEMBL3113270 IC50(app) 1.1 nM
NC(=O)c1cccc(-c2cccc(OC(=O)NCCCCN3CCN(c4ccccc4)CC3)c2)c1 CHEMBL4073966 IC50 1.1 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CC(c2ccn(-c3cnccn3)n2)C1 CHEMBL4079190 IC50 1.1 nM
CCCCCCCC/C=C\CCCCCCCC(=O)C(F)(F)F CHEMBL422064 Ki 1.2 nM
NC(=O)c1ccc(-c2cnc(C(=O)CCCCCCc3ccccc3)o2)nc1 CHEMBL219943 Ki 1.2 nM
O=C(CCCCCCc1cccc(Cl)c1Cl)c1ncc(-c2ccccn2)o1 CHEMBL226883 Ki 1.2 nM
COC(=O)c1cccc(-c2cnc(C(=O)CCc3ccc(-c4ccccc4)cc3)o2)n1 CHEMBL270487 Ki 1.2 nM
Cc1onc(NC(=O)N2CCN(c3nc(-c4cccc(F)c4)cs3)CC2)c1C CHEMBL2326196 IC50 1.2 nM
Cn1ncc2cc(-c3ccc4oc(N5Cc6ccccc6C5)nc4c3)ccc21 CHEMBL3217945 IC50 1.2 nM
NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1 CHEMBL4065510 IC50 1.2 nM
Nc1ccc(C(=O)NC2CCC(=Cc3cccc(Oc4ccc(C(F)(F)F)cn4)c3)CC2)cn1 CHEMBL4557596 IC50 1.2 nM
N#Cc1cnc(C(=O)[C@H]2CCc3cc(Oc4ccccc4)ccc3C2)o1 CHEMBL1765830 Ki 1.3 nM
CCn1ccc2cc(-c3ccc4oc(N5Cc6ccccc6C5)nc4c3)ccc21 CHEMBL1812716 IC50 1.3 nM
Cc1onc(NC(=O)N2CCN(c3nc(-c4ccc(F)cc4)ns3)CC2)c1C CHEMBL2326197 IC50 1.3 nM
CCSc1ccc(-c2cc(NC[C@H](O)c3ccccc3)ncn2)cc1 CHEMBL3121143 IC50 1.3 nM
O=C(Nc1cnccc1Cl)N1CCN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CC1 CHEMBL3809841 IC50 1.3 nM
NC(=O)c1cccc(-c2cccc(OC(=O)NCCCN3CCN(c4ccccc4)CC3)c2)c1 CHEMBL4100735 IC50 1.3 nM
Cc1cc(C(=O)NC2CCC(=Cc3cccc(Oc4ccc(C(F)(F)F)cn4)c3)CC2)cnc1N CHEMBL4474161 IC50 1.3 nM
CCCCCCCCCCOc1ccc(NC(=O)Oc2ccccc2)cc1 CHEMBL592771 IC50 1.4 nM
O=C(c1ncc(-c2ccccn2)o1)[C@H]1Cc2ccc(OCc3ccccc3)cc2C1 CHEMBL1765870 Ki 1.4 nM
O=C(c1nnco1)[C@@H]1CCc2cc(Oc3ccccc3)ccc2C1 CHEMBL1765989 Ki 1.4 nM
CCCCCCCC/C=C\CCCCCCC(=O)C(=O)OCC CHEMBL1812586 Ki 1.4 nM
O=C(Nc1cccnc1)N1CCN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CC1 CHEMBL2164602 IC50 1.4 nM
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2sccc12 CHEMBL3799465 IC50 1.4 nM
O=C(CCCCCCc1ccccc1)c1ncc(-c2cc(C(F)(F)F)ccn2)o1 CHEMBL220556 IC50 1.5 nM
COC(=O)c1nnc(C(=O)[C@H]2CCc3cc(Oc4ccccc4)ccc3C2)o1 CHEMBL1765983 Ki 1.5 nM
Cn1cnc(-c2ccc([C@H]3C[C@@H]3C(=O)NCCF)cc2)c1Sc1ccc(Cl)cn1 CHEMBL2386564 IC50 1.5 nM
O=C(Nc1cccnn1)N1CCN(c2cc(-c3ccc(F)cc3F)ncn2)CC1 CHEMBL3113269 IC50(app) 1.5 nM
O=C(CCCCCCc1ccccc1)c1ncc(-c2cc([N+](=O)[O-])ccn2)o1 CHEMBL374235 IC50 1.6 nM
COC(=O)c1nnc(C(=O)[C@@H]2CCc3cc(Oc4ccccc4)ccc3C2)o1 CHEMBL1765990 Ki 1.6 nM
NC(=O)c1cccc(-c2cccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1 CHEMBL4071240 IC50 1.6 nM
Cc1nc(-c2ccccc2)c(-c2ccccc2)n1CCCCCCNC(=O)Oc1ccccc1F CHEMBL232782 IC50 1.7 nM
CCCCCCCCCCCCCC(=O)c1nc2ncccc2o1 CHEMBL1812707 Ki 1.7 nM
Cc1onc(NC(=O)N2CCN(c3nc(-c4ccccc4)ns3)CC2)c1C CHEMBL2326189 IC50 1.7 nM
CCCCCOc1ccc(NC(=O)O/N=C/c2ccc(F)cc2)cc1 CHEMBL598047 IC50 1.8 nM
CCCCCCCCCCCCOc1ccc(NC(=O)Oc2ccccc2)cc1 CHEMBL592772 IC50 1.8 nM
COc1ccccc1N1CCN(CCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1 CHEMBL4081780 IC50 1.8 nM
O=C(Nc1cccnn1)N1CCC(=Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1 CHEMBL1651534 IC50 1.8 nM
Cc1ccc2sc(-c3ccc(NC(=O)C4CCN(S(=O)(=O)c5ccccc5Cl)CC4)cc3)nc2c1 CHEMBL5092295 IC50 1.8 nM
O=C(c1ncc(-c2ccccn2)o1)[C@H]1Cc2ccc(-c3ccccc3)cc2C1 CHEMBL1765862 Ki 1.9 nM
CCCCCCCCCCCCCCCC(=O)c1nc2ncccc2o1 CHEMBL1812706 Ki 1.9 nM
COc1nn(-c2ccc(NC(=O)OCc3ccccc3)c(C)c2)c(=O)o1 CHEMBL570812 IC50 1.9 nM
O=C(Oc1cccc(N2CCS(=O)(=O)CC2)c1)N1CCN(Cc2cccc(-c3ccccc3)c2)CC1 CHEMBL4455665 IC50 1.9 nM
CCCCCCCCC#CCCCCCCCC(=O)c1nc2ncccc2o1 CHEMBL175580 IC50 2.0 nM
CC(=O)c1cnc(C(=O)CCCCCCc2ccccc2)o1 CHEMBL219660 Ki 2.0 nM
CN(C)C(=O)c1cnc(C(=O)CCCCCCc2ccccc2)o1 CHEMBL219659 Ki 2.0 nM
O=C(CCCCCCc1ccccc1)c1ncc(-c2cc(F)ccn2)o1 CHEMBL220679 Ki 2.0 nM
NS(=O)(=O)c1cccc(-c2cnc(C(=O)CCCCCCc3ccccc3)o2)c1 CHEMBL374895 Ki 2.0 nM
CC(C)(C)OC(=O)N1CCC(CCCC(=O)c2ncco2)CC1 CHEMBL270189 IC50 2.0 nM
O=C(c1ncco1)C1CCN(Cc2cc3ccccc3s2)CC1 CHEMBL449764 IC50 2.0 nM
O=c1n(CC(F)(F)F)c2cccnc2n1[C@H]1CCCN(c2nccc(-c3ccc(Cl)s3)n2)C1 CHEMBL1761302 IC50 2.0 nM
CCn1c(=O)n([C@H]2CCCN(c3nccc(-c4cc5ccccc5s4)n3)C2)c2ncccc21 CHEMBL1761303 IC50 2.0 nM
Cc1c(C2CCCN(c3nccc(-c4cc5ccccc5s4)n3)C2)c2cccnc2n1CC#N CHEMBL1761455 IC50 2.0 nM
Cc1c([C@@H]2CCCN(c3nccc(-c4cc5ccccc5s4)n3)C2)c2cccnc2n1CCO CHEMBL1761457 IC50 2.0 nM
O=C(N1CCN(c2cccc(C(F)(F)F)c2)CC1)n1nnc2ccc(-c3ccc(Cl)cc3)nc21 CHEMBL1812719 IC50 2.0 nM
CCCCCCCC/C=C\CCCCCCC(=O)C(F)(F)F CHEMBL1812587 Ki 2.0 nM
O=C(N1CCC(Cc2ccccc2)CC1)n1nnc2ccccc21 CHEMBL2159800 IC50 2.0 nM
Nc1ncc(C(=O)NC2CCC(=Cc3cccc(Oc4ccc(C(F)(F)F)cn4)c3)CC2)cn1 CHEMBL4577896 IC50 2.0 nM
COc1ccc(-c2ccc(COC3(c4cccnc4)CN(C#N)C3)c(F)c2)cc1F CHEMBL4638402 IC50 2.0 nM
O=C(Nc1cccnc1)N1CCC(Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1 CHEMBL1651524 IC50 2.0 nM
O=C(Oc1ccc([N+](=O)[O-])cc1)N1CCN(Cc2cccc(Oc3ccccc3)c2)CC1 CHEMBL606201 IC50 2.0 nM
O=C(Nc1cccc2nsnc12)N1CCN(c2nc(-c3ccccc3)ns2)CC1 CHEMBL527204 IC50 2.02 nM
CCCCCCCCCOc1ccc(NC(=O)ON=C(C)C)cc1 CHEMBL597014 IC50 2.1 nM
CCCCCCCCCCCCOc1ccc(NC(=O)O/N=C/c2ccc(F)cc2)cc1 CHEMBL608147 IC50 2.1 nM
O=C(c1ncc(-c2ccccn2)o1)[C@H]1Cc2ccc(Oc3ccccc3)cc2C1 CHEMBL1765866 Ki 2.1 nM
CCCCCCC(=O)c1nc2ncccc2o1 CHEMBL1812709 Ki 2.1 nM
Cc1onc(NC(=O)N2CCN(c3nc(-c4ccccc4F)ns3)CC2)c1C CHEMBL2326193 IC50 2.1 nM
CCCCCCCCCCOc1ccc(NC(=O)ON=C(C)C)cc1 CHEMBL597215 IC50 2.2 nM
CCCCOc1ccc(NC(=O)O/N=C/c2ccc(F)cc2)cc1 CHEMBL598046 IC50 2.2 nM
O=C(c1ncco1)[C@H]1CCc2cc(Oc3ccccc3)ccc2C1 CHEMBL1765828 Ki 2.2 nM
COC(=O)c1cccc(-c2cnc(C(=O)[C@H]3CCc4cc(Oc5ccccc5)ccc4C3)o2)n1 CHEMBL1765832 Ki 2.2 nM
O=C(Nc1cccnn1)N1CCN(c2cc(-c3ccc(F)cc3F)ccn2)CC1 CHEMBL3113268 IC50(app) 2.2 nM
O=C(NC1CCC(=Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1)c1cccnc1 CHEMBL4560227 IC50 2.2 nM
O=C(NC1CCC(=Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1)c1cnc2[nH]ccc2c1 CHEMBL4460120 IC50 2.2 nM
CCCCCCCC/C=C\CCCCCCCC(=O)c1nc2ncccc2o1 CHEMBL35925 Ki 2.3 nM
O=C(CCCCCCc1ccccc1)c1ncc(-c2ccncn2)o1 CHEMBL177922 Ki 2.3 nM
CCCCCCCC/C=C\CCCCCCC(=O)c1nc2ncccc2o1 CHEMBL457924 Ki 2.3 nM
CCCCCCCOc1ccc(NC(=O)O/N=C/c2ccc(F)cc2)cc1 CHEMBL598048 IC50 2.3 nM
CCCCCCCOc1ccc(NC(=O)O/N=C/c2cccnc2)cc1 CHEMBL605005 IC50 2.3 nM
COc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1 CHEMBL4099798 IC50 2.3 nM
O=C(Oc1cccc(N2CCS(=O)(=O)CC2)c1)N1CCN(Cc2cccc(Oc3ccccc3)c2)CC1 CHEMBL4560909 IC50 2.3 nM
O=C(Nc1cccnn1)N1CCC(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1 CHEMBL3800500 Ki 2.358 nM
CCCCCCCCOc1ccc(NC(=O)ON=C(C)C)cc1 CHEMBL597295 IC50 2.4 nM
CCCCCCCCCCCCOc1ccc(NC(=O)O/N=C/c2ccccc2)cc1 CHEMBL596617 IC50 2.4 nM
O=C(Nc1cccnc1)N1CCN(c2nc(-c3ccccc3)ns2)CC1 CHEMBL513553 IC50 2.4 nM
O=C(Nc1cccnc1)N1CCN(Cc2cccc(Oc3ccc(Br)cc3)c2)CC1 CHEMBL3808688 IC50 2.4 nM
CN(C)c1ccc(C2CCN(C(=O)Oc3cccc(N4CCS(=O)(=O)CC4)c3)CC2)cc1 CHEMBL4466465 IC50 2.4 nM
O=C(CCCC1CCN(S(=O)(=O)c2ccccc2)CC1)c1ncco1 CHEMBL255146 IC50 2.5 nM
c1ccc(CCN2CCc3c(ccnc3Nc3cnc4ccccc4c3)C2)cc1 CHEMBL3220531 IC50 2.6 nM
COc1ccccc1N1CCN(CCCNC(=O)Oc2ccc(-c3ccccc3)cc2)CC1 CHEMBL4095588 IC50 2.6 nM
CC1CN(c2ccccc2)CCN1C(=O)Oc1cccc(N2CCS(=O)(=O)CC2)c1 CHEMBL4559165 IC50 2.6 nM
O=C(NC1CCC(=Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1)c1cncnc1 CHEMBL4575497 IC50 2.6 nM
O=C(NC1CCC(=Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1)c1cn[nH]c1 CHEMBL4538101 IC50 2.6 nM
O=C(N1CCN(Cc2cccc(Oc3ccccc3)c2)CC1)n1cncn1 CHEMBL3356971 pIC50 2.692 nM
O=C(Nc1cccc2nccn12)N1CCN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CC1 CHEMBL2207356 IC50 2.7 nM
COc1cc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1-c1cccc(C(N)=O)c1 CHEMBL4078351 IC50 2.7 nM
NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4ccccc4C(F)(F)F)CC3)cc2)c1 CHEMBL4060896 IC50 2.7 nM
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc2ccccc2c1 CHEMBL4742989 IC50 2.7 nM
O=C(Nc1ncncc1Cl)N1C[C@H]2CN(Cc3cccc(Oc4ccc(Cl)cc4)c3)C[C@H]2C1 CHEMBL4747373 IC50(app) 2.7 nM
O=C(Oc1ccccc1)N1CCC(c2nc(C3=NOC4(CCCc5ccccc54)C3)cs2)CC1 CHEMBL3799076 Ki 2.735 nM
Cc1ccc(-c2cnc(C(=O)CCCCCCc3ccccc3)o2)nc1 CHEMBL220377 Ki 2.8 nM
COc1ccccc1N1CCN(CCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1 CHEMBL4072282 IC50 2.8 nM
COC(=O)c1cnc(C(=O)[C@H]2CCc3cc(OCc4ccccc4)ccc3C2)o1 CHEMBL1765835 Ki 2.9 nM
O=C(Nc1cccnn1)N1CCN(c2nc(-c3ccccc3)ns2)CC1 CHEMBL2326190 IC50 2.9 nM
CCCCCCCCCCCCS(=O)(=O)F CHEMBL97038 IC50 3.0 nM
CCCCCCCCCCCCP(=O)(F)OC CHEMBL113263 IC50 3.0 nM
O=C(CCCCCCc1ccccc1)c1ncc(Br)o1 CHEMBL373555 Ki 3.0 nM
O=C(CCCCCCc1ccccc1)c1ncc(I)o1 CHEMBL220555 Ki 3.0 nM
NS(=O)(=O)c1ccc(-c2cnc(C(=O)CCCCCCc3ccccc3)o2)s1 CHEMBL220312 Ki 3.0 nM
O=C(CCCC1CCN(C(=O)CCC2CCCCC2)CC1)c1ncco1 CHEMBL256009 IC50 3.0 nM
O=C(CCCCCCc1ccccc1)c1nnc(-c2ccccn2)s1 CHEMBL477372 Ki 3.0 nM
CCCCCCCC/C=C\CCCCCCCC(=O)c1ncc(-c2ccccn2)o1 CHEMBL426230 Ki 3.0 nM
Cc1c(C2CCCN(c3nccc(-c4cc5ccccc5s4)n3)C2)c2cccnc2n1CCO CHEMBL1761456 IC50 3.0 nM
Cc1ccccc1N1CCN(C(=O)n2nnc3ccccc32)CC1 CHEMBL2159783 IC50 3.0 nM
O=C(Nc1ccnc2nccn12)N1CCN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CC1 CHEMBL2207358 IC50 3.0 nM
CN(CCF)C(=O)[C@H]1C[C@@H]1c1ccc(-c2ncn(C)c2Sc2ccc(Cl)cn2)cc1 CHEMBL2386565 IC50 3.0 nM
CCOc1ccc(-c2cc(NC[C@H](O)c3ccccc3)ncn2)cc1C(F)(F)F CHEMBL3121113 IC50 3.0 nM
O=C(Nc1cccnn1)N1CC(Oc2ccc(-c3cccc(OCCOCc4ccccc4)c3)cn2)C1 CHEMBL3677693 IC50 3.0 nM
Cc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1 CHEMBL4094794 IC50 3.0 nM
Cc1cc(C(=O)NC2CCC(=Cc3cccc(Oc4ccc(C(F)(F)F)cn4)c3)CC2)cnc1N CHEMBL4468693 IC50 3.0 nM
O=C(NC1CCC(=Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1)c1ccc(-n2nccn2)nc1 CHEMBL4466424 IC50 3.0 nM
N#Cc1cnc(C(=O)[C@H]2CCc3cc(OCc4ccccc4)ccc3C2)o1 CHEMBL1765836 Ki 3.2 nM
O=C(c1ncc(-c2ccccn2)o1)[C@H]1CCc2cc(OCc3ccccc3)ccc2C1 CHEMBL1765837 Ki 3.2 nM
Cc1onc(NC(=O)N2CCN(c3nc(-c4cccc(F)c4)ns3)CC2)c1C CHEMBL2326195 IC50 3.2 nM
CN(C)C(=O)[C@H]1C[C@@H]1c1ccc(-c2ncn(CCF)c2Sc2ccc(Cl)cn2)cc1 CHEMBL2386563 IC50 3.2 nM
CC(=O)c1ccc(-c2cc(NC[C@H](O)c3ccccc3)ncn2)cc1F CHEMBL3121116 IC50 3.2 nM
Cn1ncc2c(-c3ccc4oc(N5Cc6ccccc6C5)nc4c3)cccc21 CHEMBL3217946 IC50 3.2 nM
Cc1cccc(-c2cnc(C(=O)CCCCCCc3ccccc3)o2)n1 CHEMBL220783 Ki 3.3 nM
Cn1cnc(-c2ccc([C@H]3C[C@@H]3C(N)=O)cc2)c1Sc1ccc(Cl)cn1 CHEMBL2386561 IC50 3.3 nM
NC(=O)c1ccc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c2ccccc12 CHEMBL3798211 IC50 3.3 nM
O=C(Nc1cnccc1Cl)N1CCN(Cc2cccc(Oc3ccc(F)cc3)c2)CC1 CHEMBL3809071 IC50 3.3 nM
O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1 CHEMBL4103339 IC50 3.3 nM
Cc1ccc(C)c(OC(=O)N2CCC(c3nc(C4=NOC(c5ccccc5)C4)cs3)CC2)c1 CHEMBL3798265 Ki 3.302 nM
N#Cc1cnc(C(=O)[C@H]2CCc3cc(-c4ccccc4)ccc3C2)o1 CHEMBL1765824 Ki 3.4 nM
O=C(Nc1cnc2[nH]ccc2c1)N1CCN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CC1 CHEMBL2207344 IC50 3.4 nM
O=C(N1CCN(Cc2ccc(Oc3ccccc3)cc2)CC1)n1ccnc1 CHEMBL3356980 IC50 3.4 nM
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(C(=O)O)c2ccccc12 CHEMBL3798504 IC50 3.4 nM
COC(=O)c1ccc(-c2cnc(C(=O)CCCCCCc3ccccc3)o2)nc1 CHEMBL374708 Ki 3.5 nM
CCCCCOc1ccc(NC(=O)O/N=C/c2ccccc2)cc1 CHEMBL598244 IC50 3.5 nM
O=C(CCCCCCc1ccccc1)c1ncc(C(=O)C(F)(F)F)o1 CHEMBL220378 Ki 3.5 nM
NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4ccccc4)CC3)cc2)c1 CHEMBL4090581 IC50 3.5 nM
O=C(Oc1cccc(N2CCS(=O)(=O)CC2)c1)N1CCC(c2ccc(N3CCCC3)cc2)CC1 CHEMBL4458978 IC50 3.5 nM
CC(C)c1ccc(CN2CCC(CCCC(=O)c3ncco3)CC2)cc1 CHEMBL273152 IC50 3.6 nM
C=CCOC(=O)N1C[C@@H]([C@@H](C)OC(=O)CCCc2ccccc2)C1=O CHEMBL2313948 pI50 3.631 nM
CCCCCCCC/C=C\CCCCCCC(=O)c1nc2ccncc2o1 CHEMBL512377 Ki 3.7 nM
O=C(Nc1cnc2cccnn12)N1CCN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CC1 CHEMBL2203328 IC50 3.7 nM
O=C(Nc1noc2ccccc12)N1CCN(c2nc(-c3ccccc3)cs2)CC1 CHEMBL2326181 IC50 3.7 nM
O=C(Oc1cccc(N2CCS(=O)(=O)CC2)c1)N1CCC(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL4440682 IC50 3.7 nM
NC(=O)c1ccn(-c2cccc(OC(=O)NCCCCCCc3ccccc3)c2)c1 CHEMBL2165084 IC50 3.72 nM
Cc1cc(C)cc(OC(=O)N2CCC(c3nc(C4=NOC(c5ccccc5)C4)cs3)CC2)c1 CHEMBL3800617 Ki 3.962 nM
CCCCCCCC/C=C\CCCCCCCC(=O)c1nnc(-c2ccccn2)o1 CHEMBL178563 IC50 4.0 nM
O=C(CCCCCc1ccccc1)c1nnc(-c2ccccn2)o1 CHEMBL424976 IC50 4.0 nM
CCCCCCCCCCCCCCCCCCS(=O)(=O)F CHEMBL191481 IC50 4.0 nM
O=C(CCCC1CCN(C(=O)OCc2ccccc2)CC1)c1ncco1 CHEMBL255760 IC50 4.0 nM
CC(C)OC(=O)N1CCC(CCCC(=O)c2ncco2)CC1 CHEMBL255544 IC50 4.0 nM
O=C(Oc1ccc([N+](=O)[O-])cc1)N1CCC(C(O)(c2ccc3c(c2)OCO3)c2ccc3c(c2)OCO3)CC1 CHEMBL576786 IC50 4.0 nM
Nc1ncc(C(=O)NC2CCC(=Cc3cccc(Oc4ccc(C(F)(F)F)cn4)c3)CC2)cc1Cl CHEMBL4562421 IC50 4.0 nM
O=C(c1ncc(I)o1)[C@H]1CCc2cc(OCc3ccccc3)ccc2C1 CHEMBL1765859 Ki 4.1 nM
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc(-c2ccccc2)c1 CHEMBL4063681 IC50 4.1 nM
COc1ccc(N2CCN(C(=O)Oc3cccc(N4CCOCC4)c3)[C@H](C)C2)cc1 CHEMBL4572794 IC50 4.1 nM
Clc1ccc(Sc2oc(C3CCOCC3)nc2-c2ccc3[nH]ncc3c2)cc1 CHEMBL3945257 IC50 4.192 nM
Cc1nc(-c2ccccc2)c(-c2ccccc2)n1CCCCCC(C)NC(=O)Oc1ccccc1F CHEMBL232783 IC50 4.2 nM
O=C(Nc1cccnc1)N1CCC(Cc2cccc(Oc3ccc(Cl)cc3)c2)CC1 CHEMBL3809332 IC50 4.3 nM
COc1cc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1-c1ccccc1 CHEMBL4098174 IC50 4.3 nM
O=C(c1ncc(-c2ccccn2)o1)[C@H]1CCc2cc(Oc3ccccc3)ccc2C1 CHEMBL1765831 Ki 4.4 nM
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(F)c2ccccc12 CHEMBL3799311 IC50 4.5 nM
CCCCOc1ccc(CNC(=O)Oc2ccc(F)cc2)cc1 CHEMBL607558 IC50 4.6 nM
O=C(CCCCCCc1ccccc1)c1ncc(-c2ncccn2)o1 CHEMBL368284 Ki 4.6 nM
O=C(CCCCCCc1ccccc1)c1ncc(-c2cocn2)o1 CHEMBL181957 Ki 4.6 nM
O=C(Nc1ccccc1)N1CCC(Cc2cnc3ccccc3c2)CC1 CHEMBL560590 IC50 4.6 nM
O=C(Nc1noc2ccccc12)N1CCN(c2nc(-c3ccccc3)ns2)CC1 CHEMBL459152 IC50 4.8 nM
O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc2c(c1)[nH]c1ccccc12 CHEMBL4092900 IC50 4.8 nM
CCCCCCCCCCCOc1ccc(NC(=O)ON=C(C)C)cc1 CHEMBL597216 IC50 4.9 nM
O=C(Oc1cncc(N2CCS(=O)(=O)CC2)c1)N1CCC(c2ccc(F)cc2)CC1 CHEMBL4558868 IC50 4.9 nM
O=C(O)c1cccc(-c2cnc(C(=O)CCCCCCc3ccccc3)o2)c1 CHEMBL441556 Ki 5.0 nM
O=C(CCCCCCc1ccccc1)c1ncc(Cl)o1 CHEMBL220613 Ki 5.0 nM
NC(=O)c1cnc(C(=O)CCCCCCc2ccccc2)o1 CHEMBL219675 Ki 5.0 nM
COc1cc(-c2cnc(C(=O)CCCCCCc3ccccc3)o2)nc(OC)n1 CHEMBL220449 Ki 5.0 nM
O=C(CCCCCCc1ccccc1)c1ncc(-c2cc(=O)[nH]c(=O)[nH]2)o1 CHEMBL220687 IC50 5.0 nM
CC(C)Oc1cccc(CN2CCC(CCCC(=O)c3ncco3)CC2)c1 CHEMBL430036 IC50 5.0 nM
C=CCCC(=O)N1C[C@@H]([C@@H](C)OC(=O)CCCc2ccccc2)C1=O CHEMBL2151432 IC50 5.0 nM
CCCCCCCCCCCCOc1ccc(NC(=O)ON=C(C)C)cc1 CHEMBL599357 IC50 5.0 nM
O=C(Nc1ccccc1F)N1CCC2(CC1)OCc1cc(Br)ccc1O2 CHEMBL1761279 IC50 5.0 nM
Cc1[nH]c2ncccc2c1C1CCCN(c2nccc(-c3cc4ccccc4s3)n2)C1 CHEMBL1761307 IC50 5.0 nM
NC(=O)[C@H]1C[C@@H]1c1ccc(-c2nn(C3CC3)cc2Sc2ccc(Cl)cc2)cc1 CHEMBL2386555 IC50 5.0 nM
CC(C)c1ccc(-c2cc(NC[C@H](O)c3ccccc3)ncn2)cc1 CHEMBL3121136 IC50 5.0 nM
Nc1ccc(C(=O)NC2CCC(=Cc3cccc(Oc4ccc(C(F)(F)F)cn4)c3)CC2)cn1 CHEMBL4460637 IC50 5.0 nM
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2[nH]ccc12 CHEMBL3800421 IC50 5.1 nM
O=C(NC1CCC(=Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1)c1ccc(Cl)nc1 CHEMBL4533398 IC50 5.1 nM
O=C(Nc1nocc1Cl)N1CCN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CC1 CHEMBL2207365 IC50 5.2 nM
Cc1nc(-c2ccccc2)c(-c2ccccc2)n1CCCCCCNC(=O)Oc1ccccc1 CHEMBL233593 IC50 5.3 nM
O=C(CCCCCCc1ccccc1)c1ncc(-c2cnccn2)o1 CHEMBL177858 Ki 5.3 nM
O[C@@H](CNc1cc(-c2ccc(C(F)(F)F)c(Cl)c2)ncn1)c1ccccc1 CHEMBL3121119 IC50 5.3 nM
Cc1ccccc1N1CCN(CCCNC(=O)Oc2cccc3ccccc23)CC1 CHEMBL3798943 IC50 5.3 nM
O[C@@H](CNc1cc(-c2ccc(C(F)(F)F)c(Cl)c2)ncn1)c1cccc(F)c1 CHEMBL4761895 IC50 5.3 nM
CSc1ccc([C@@H](O)CNc2cc(-c3ccc(C(F)(F)F)c(Cl)c3)ncn2)cc1 CHEMBL4795520 IC50 5.3 nM
O[C@@H](CNc1cc(-c2ccc(C(F)(F)F)c(Cl)c2)ncn1)c1cccc(C(F)(F)F)c1 CHEMBL4781418 IC50 5.3 nM
O[C@@H](CNc1cc(-c2ccc(C(F)(F)F)c(Cl)c2)ncn1)c1ccccc1F CHEMBL4758878 IC50 5.3 nM
O[C@@H](CNc1cc(-c2ccc(C(F)(F)F)c(Cl)c2)ncn1)c1cccc(OC(F)(F)F)c1 CHEMBL4779467 IC50 5.3 nM
N#Cc1ccc([C@@H](O)CNc2cc(-c3ccc(C(F)(F)F)c(Cl)c3)ncn2)cc1 CHEMBL4763151 IC50 5.3 nM
N#Cc1cccc([C@@H](O)CNc2cc(-c3ccc(C(F)(F)F)c(Cl)c3)ncn2)c1 CHEMBL4745395 IC50 5.3 nM
O[C@@H](CNc1cc(-c2ccc(C(F)(F)F)c(Cl)c2)ncn1)c1ccc(F)c(Cl)c1 CHEMBL4779355 IC50 5.3 nM
O[C@@H](CNc1cc(-c2ccc(C(F)(F)F)c(Cl)c2)ncn1)c1ccc(Cl)c(F)c1 CHEMBL4750018 IC50 5.3 nM
N#Cc1cc([C@@H](O)CNc2cc(-c3ccc(C(F)(F)F)c(Cl)c3)ncn2)ccc1F CHEMBL4763787 IC50 5.3 nM
O[C@@H](CNc1cc(-c2ccc(C(F)(F)F)c(Cl)c2)ncn1)c1ccc(F)c(F)c1 CHEMBL3121127 IC50 5.3 nM
CCCCCCCCOc1ccc(NC(=O)Oc2ccccc2)cc1 CHEMBL598572 IC50 5.4 nM
COC(=O)c1cnc(C(=O)[C@H]2CCc3cc(Oc4ccccc4)ccc3C2)o1 CHEMBL1765829 Ki 5.4 nM
C=CCNC(=O)N1C[C@@H]([C@@H](C)OC(=O)CCCc2ccccc2)C1=O CHEMBL2313949 pI50 5.495 nM
COC(=O)c1ccc(-c2cnc(C(=O)CCCCCCc3ccccc3)o2)o1 CHEMBL220615 Ki 5.5 nM
O=C(CCCCCCc1ccccc1)c1ncc(-c2cccnn2)o1 CHEMBL367307 Ki 5.6 nM
COC(=O)c1cccc(-c2cnc(C(=O)[C@H]3Cc4ccc(OCc5ccccc5)cc4C3)o2)n1 CHEMBL1765871 Ki 5.8 nM
O=C(CCCCCCc1ccccc1)c1ncc(-c2cscn2)o1 CHEMBL1812712 Ki 5.8 nM
O=C(Nc1cccc2nsnc12)N1CCN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CC1 CHEMBL2207340 IC50 5.8 nM
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)C=[N+]=[N-] CHEMBL371633 IC50 6.0 nM
O=Cc1cnc(C(=O)CCCCCCc2ccccc2)o1 CHEMBL220727 Ki 6.0 nM
NC(=O)c1cccc(-c2cnc(C(=O)CCCCCCc3ccccc3)o2)c1 CHEMBL223406 Ki 6.0 nM
O=C(CCCC1CCN(S(=O)(=O)CCc2ccccc2)CC1)c1ncco1 CHEMBL257894 IC50 6.0 nM
CCn1c(=O)n([C@H]2CCCN(c3nccc(-c4cc5ccccc5o4)n3)C2)c2ncccc21 CHEMBL1761285 IC50 6.0 nM
O=C(Nc1ccccc1)N1CCN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CC1 CHEMBL2164596 IC50 6.0 nM
O=C(N1CCN(c2ccccc2)CC1)n1cncn1 CHEMBL3356960 IC50 6.0 nM
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(O)c2ccccc12 CHEMBL3797771 IC50 6.0 nM
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)c(F)c1 CHEMBL4062484 IC50 6.0 nM
O=C(NC1CCC(=Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1)c1cn[nH]n1 CHEMBL4466023 IC50 6.0 nM
CCCCOc1ccc(CNC(=O)Oc2cccnc2)cc1 CHEMBL596877 IC50 6.1 nM
CCCCCOc1ccc(NC(=O)O/N=C/c2cccnc2)cc1 CHEMBL597728 IC50 6.1 nM
O=C(c1ncco1)[C@H]1CCc2cc(OCc3ccccc3)ccc2C1 CHEMBL1765834 Ki 6.1 nM
COc1nn(-c2ccc(Oc3ccccc3)cc2)c(=O)o1 CHEMBL2171700 IC50 6.1 nM
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2ccccc12 CHEMBL3798032 Activity 6.1 nM
COC(=O)c1cccc(-c2cnc(C(=O)C3Cc4ccc(-c5ccccc5)cc4C3)o2)n1 CHEMBL1765863 Ki 6.2 nM
O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2ccccc12 CHEMBL3799902 IC50 6.2 nM
O=C(c1nnc(-c2ccccn2)o1)[C@@H]1CCc2cc(Oc3ccccc3)ccc2C1 CHEMBL1765991 Ki 6.3 nM
Cn1c(-c2ccccn2)nc(-c2ccc(S(C)(=O)=O)nc2)c1Sc1ccc(Cl)cc1 CHEMBL1812714 IC50 6.3 nM
O[C@@H](CNc1cc(-c2ccc(OCC(F)(F)F)c(F)c2)ncn1)c1ccccc1 CHEMBL3121115 IC50 6.3 nM
COc1ccc(C2CCN(C(=O)Oc3cccc(N4CCS(=O)(=O)CC4)c3)CC2)cc1 CHEMBL4590612 IC50 6.3 nM
O=C(Nc1ccon1)N1C[C@H]2CN(Cc3cccc(Oc4ccc(Cl)cc4)c3)C[C@H]2C1 CHEMBL4755710 IC50(app) 6.3 nM
COc1ccccc1N1CCN(CCCNC(=O)Oc2cccc3ccccc23)CC1 CHEMBL3798334 IC50 6.4 nM
CCCCCCOc1ccc(NC(=O)O/N=C/c2ccc(F)cc2)cc1 CHEMBL610214 IC50 6.5 nM
O=C(Nc1cncc2ccccc12)N1CCN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CC1 CHEMBL2207343 IC50 6.7 nM
O=C(NC1CCC(=Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1)c1ccc(-n2cccn2)nc1 CHEMBL4435842 IC50 6.7 nM
O=C(CCCc1ccccc1)c1nc2ncccc2o1 CHEMBL257638 Ki 6.9 nM
O=C(NCCCN1CCN(c2ccccc2C(F)(F)F)CC1)Oc1cccc2ccccc12 CHEMBL3800194 IC50 6.9 nM
CNC(=O)c1cnc(C(=O)CCCCCCc2ccccc2)o1 CHEMBL219681 Ki 7.0 nM
COC(=O)c1ccc(-c2cnc(C(=O)CCCCCCc3ccccc3)o2)s1 CHEMBL219871 Ki 7.0 nM
O=C(O)c1ccc(-c2cnc(C(=O)CCCCCCc3ccccc3)o2)nc1 CHEMBL219953 Ki 7.0 nM
COCCOc1ccc(Cl)c(-c2ccc(OC3CN(C(=O)Nc4cccnn4)C3)nc2)c1 CHEMBL3677698 IC50 7.0 nM
O=C(Nc1ccc(-c2nc3ccccc3s2)cc1)C1CCN(S(=O)(=O)c2ccccc2Cl)CC1 CHEMBL5089361 IC50 7.0 nM
CCCCCCCC/C=C\CCCCCCC(=O)c1nc2cnccc2o1 CHEMBL457925 Ki 7.2 nM
O=C(c1ncc(-c2ccccn2)o1)[C@H]1CCc2cc(-c3ccccc3)ccc2C1 CHEMBL1765825 Ki 7.2 nM
O=C(NCCCCCCc1ccccc1)Oc1cccc(-c2nn[nH]n2)c1 CHEMBL5401122 IC50 7.54 nM
Cc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3ccccc3)cc2)CC1 CHEMBL4087889 IC50 7.6 nM
CCCCOc1ccc(C(CC)NC(=O)Oc2ccccc2F)cc1 CHEMBL597030 IC50 7.7 nM
Cc1nc2cc(NC(=O)N3CCN(Cc4cccc(Oc5ccc(Cl)cc5)c4)CC3)ccc2o1 CHEMBL2207342 IC50 7.7 nM
O=C(Nc1cccnn1)N1CCN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CC1 CHEMBL2207361 IC50 7.7 nM
O=C(Oc1cccc(N2CCS(=O)(=O)CC2)c1)N1CCC(c2ccc(N3CCC3)cc2)CC1 CHEMBL4435546 IC50 7.9 nM
O=C(CCCCCCCc1ccccc1)c1ncc(-c2ccccn2)o1 CHEMBL177708 IC50 8.0 nM
O=C(CCCCCCc1ccccc1)c1ncc(C(=O)N2CCCCC2)o1 CHEMBL376417 Ki 8.0 nM
COC(=O)c1cccc(-c2cnc(C(=O)CCCCCCc3ccccc3)o2)n1 CHEMBL219880 Ki 8.0 nM
CCCCCCOc1ccc(NC(=O)O/N=C/c2ccccc2)cc1 CHEMBL598245 IC50 8.0 nM
O=C(c1ncc(I)o1)C1CCc2cc(OCc3ccccc3)ccc2C1 CHEMBL1765858 Ki 8.0 nM
C=CCCC(=O)N1C[C@@H]([C@@H](C)OCCCCc2ccccc2)C1=O CHEMBL2151436 IC50 8.0 nM
O=C(Nc1cnccc1Cl)N1CC2(CCN(Cc3cccc(Oc4ccc(Cl)cc4)c3)CC2)C1 CHEMBL3112760 IC50(app) 8.0 nM
CCCCCOc1ccc(-c2cc(C(=O)NC34CC5CC(CC(C5)C3)C4)no2)cc1 CHEMBL2414027 IC50 8.0 nM
O[C@@H](CNc1cc(-c2ccc(SC(F)(F)F)cc2)ncn1)c1ccccc1 CHEMBL3121144 IC50 8.0 nM
O=C(Nc1cccnc1)N1CCN(Cc2cc(Cl)cc(Oc3ccc(Cl)cc3)c2)CC1 CHEMBL3809180 IC50 8.0 nM
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc2c(c1)[nH]c1ccccc12 CHEMBL4072140 IC50 8.0 nM
O=C(Oc1cccc(N2CCS(=O)(=O)CC2)c1)N1CCC(c2ccccc2)CC1 CHEMBL4453319 IC50 8.0 nM
Cc1cc(C(N)=O)c(-c2cccc(OC(=O)N3CCN(CCCc4ccccc4)CC3)c2)o1 CHEMBL5430250 IC50 8.29 nM
CCCCCCOc1ccc(NC(=O)O/N=C/c2cccnc2)cc1 CHEMBL597729 IC50 8.3 nM
CCCCCCCOc1ccc(NC(=O)ON=C(C)C)cc1 CHEMBL597294 IC50 8.4 nM
CCCCOc1ccc(NC(=O)O/N=C/c2ccccc2)cc1 CHEMBL598243 IC50 8.5 nM
CCCCCCCOc1ccc(NC(=O)O/N=C/c2ccccc2)cc1 CHEMBL597228 IC50 8.6 nM
CCCCCCCOc1ccc(NC(=O)Oc2ccccc2)cc1 CHEMBL599381 IC50 8.6 nM
C[S+]([O-])c1ccc(-c2nc(C3=CCC(O)CC3)oc2Sc2ccc(Cl)cc2)cc1 CHEMBL3889730 IC50 8.678 nM
CCCCOc1ccc(CNC(=O)Oc2ccc(F)cc2F)cc1 CHEMBL596875 IC50 8.7 nM
O=C(Nc1cnccn1)N1CCN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CC1 CHEMBL2207360 IC50 8.7 nM
CCCCCCCC/C=C\CCCCCCCC(=O)C(=O)OCC CHEMBL457814 Ki 9.0 nM
CCn1c(=O)n([C@@H]2CCCN(c3nccc(-c4cc5ccccc5o4)n3)C2)c2ncccc21 CHEMBL1761284 IC50 9.0 nM
Cn1cc(C2CCCN(c3nccc(-c4cc5ccccc5s4)n3)C2)c2cccnc21 CHEMBL1761305 IC50 9.0 nM
N#CCn1cc(C2CCCN(c3nccc(-c4cc5ccccc5s4)n3)C2)c2cccnc21 CHEMBL1761306 IC50 9.0 nM
O=C(N1CCN(Cc2cccc(-c3ccccc3)c2)CC1)n1nnc2ccccc21 CHEMBL2159777 IC50 9.0 nM
O=C(N1CCN(Cc2cccc(Cl)c2)CC1)n1nnc2ccccc21 CHEMBL2159805 IC50 9.0 nM
COCCOc1cccc(-c2ccc(OC3CN(C(=O)Nc4ccncn4)C3)nc2)c1 CHEMBL3677689 IC50 9.0 nM
COc1ccc(Oc2cccc(CN3CCN(C(=O)Nc4ccccc4)CC3)c2)cc1 CHEMBL2164599 IC50 9.0 nM
O=C(NC1CCC(=Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1)c1cccnn1 CHEMBL4455597 IC50 9.0 nM
CCCCCCCC/C=C\CCCCCCC(C)C(=O)c1nc2ncccc2o1 CHEMBL191424 Ki 9.1 nM
CCCCOc1ccc(CNC(=O)Oc2ccccc2F)cc1 CHEMBL596876 IC50 9.2 nM
CCCCCCCCCCOc1ccc(NC(=O)Oc2ccccc2F)cc1 CHEMBL591825 IC50 9.2 nM
CCCOc1ccc(NC(=O)O/N=C/c2ccccc2)cc1 CHEMBL592635 IC50 9.3 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CC(c2ccn(C3CCOCC3)n2)C1 CHEMBL4102496 IC50 9.4 nM
Clc1ccc(Sc2oc(C3CCOCC3)nc2-c2ccc(N3CCNCC3)nc2)cc1 CHEMBL3965548 IC50 9.605 nM
C=CCCCC(=O)N1C[C@@H]([C@@H](C)OC(=O)CCCc2ccccc2)C1=O CHEMBL570331 pI50 9.772 nM
Cc1ccc(-c2csc(-c3ccc(NC(=O)C4CCN(S(=O)(=O)c5ccccc5Cl)CC4)cc3)n2)cc1 CHEMBL5076329 IC50 9.8 nM