COc1ccc(CNC(=O)C(=O)[C@@H]2CCCN2C(=O)CNC(=O)c2ccnc3ccccc23)cc1OC CHEMBL4877950 IC50 0.089 nM
CC(C)(C)OC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4878759 IC50 0.13 nM
COc1ccc(CNC(=O)C(=O)[C@@H]2CCCN2C(=O)CNC(=O)c2ccnc3ccccc23)cc1 CHEMBL4864809 IC50 0.18 nM
COc1ccc(CCNC(=O)C(=O)[C@@H]2CCCN2C(=O)CNC(=O)c2ccnc3ccccc23)cc1OC CHEMBL4853661 IC50 0.19 nM
COc1cccc(CNC(=O)C(=O)[C@@H]2CCCN2C(=O)CNC(=O)c2ccnc3ccccc23)c1 CHEMBL4850601 IC50 0.22 nM
COC(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4876026 IC50 0.31 nM
O=C(NCC(=O)N1CCOCC1)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4868869 IC50 0.32 nM
COC(=O)[C@H](CCC(=O)NCc1ccccc1)NC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4850484 IC50 0.33 nM
COC(=O)c1ccc(NC(=O)C(=O)[C@@H]2CCCN2C(=O)CNC(=O)c2ccnc3ccccc23)cc1 CHEMBL4873985 IC50 0.42 nM
CCOC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4867484 IC50 0.42 nM
O=C(NCc1ccc(F)cc1)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4864133 IC50 0.44 nM
O=C(NCC(=O)N1CCC[C@H]1B(O)O)c1ccncc1 CHEMBL2333025 IC50 0.47 nM
COC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4854865 IC50 0.5 nM
CC(C)(C)NC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4871602 IC50 0.53 nM
CCCCCNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4855449 IC50 0.58 nM
Cc1ccc(CNC(=O)C(=O)[C@@H]2CCCN2C(=O)CNC(=O)c2ccnc3ccccc23)c(C)c1 CHEMBL4859756 IC50 0.63 nM
O=C(NCCc1ccccc1)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4863249 IC50 0.63 nM
COC(=O)[C@H](CCC(=O)OCc1ccccc1)NC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4868282 IC50 0.63 nM
O=C(NC1CC1)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4847764 IC50 0.64 nM
CCCCCCNC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4851238 IC50 0.67 nM
O=C(NCc1ccccc1)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4855309 IC50 0.77 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(Cc2ccc(Cl)cc2Cl)n1 CHEMBL4762591 IC50 1.0 nM
O=C(NCC(=O)N1CCC[C@H]1B(O)O)c1cccnc1 CHEMBL2333023 IC50 1.1 nM
COC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4846405 IC50 1.1 nM
COC(=O)C(C)NC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4870279 IC50 1.1 nM
CC(C)NC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4870593 IC50 1.1 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)[C@@H]1C[C@@H](CC(=O)N2Cc3ccccc3C2)C(=O)N1 CHEMBL1243153 Ki 1.3 nM
COc1ccc(NC(=O)C(=O)[C@@H]2CCCN2C(=O)CNC(=O)c2ccnc3ccccc23)cc1 CHEMBL4871573 IC50 1.5 nM
COc1ccc(CNC(=O)CNC(=O)C(=O)[C@@H]2CCCN2C(=O)CNC(=O)c2ccnc3ccccc23)cc1OC CHEMBL4861963 IC50 1.7 nM
O=C(NCC(=O)N1CCCC1)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4869146 IC50 1.8 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(Cc2ccc(Cl)c(Cl)c2)n1 CHEMBL4786982 IC50 2.0 nM
COC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4864489 IC50 2.1 nM
O=C(NCC(=O)N1CCC[C@H]1B(O)O)c1cccc2ccccc12 CHEMBL1243373 IC50 2.3 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL3233842 IC50 2.3 nM
O=C(CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12)NC1CC1 CHEMBL4872140 IC50 2.7 nM
C[C@@H](NC(=O)c1ccncc1Cl)C(=O)N1CCC[C@H]1B(O)O CHEMBL2333030 IC50 3.4 nM
O=C(NC(c1ccccc1)c1ccccc1)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4850470 IC50 3.4 nM
O=C(CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12)NCc1ccccc1 CHEMBL4863606 IC50 3.7 nM
COC(=O)[C@H](CC(=O)OCc1ccccc1)NC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4870506 IC50 3.7 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(Cc2ccccc2-c2ccc3ccccc3c2)n1 CHEMBL4750058 IC50 4.0 nM
CC(C)NC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4863090 IC50 4.0 nM
COC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4875452 IC50 4.3 nM
O=C(CNC12CC3CC(CC(C3)C1)C2)N1CCC[C@@H]1B(O)O CHEMBL373269 IC50 4.6 nM
Cc1ccc(SCc2nc(C(=O)NCC(=O)N3CC(F)(F)C[C@H]3C#N)cs2)cc1 CHEMBL4780357 IC50 5.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(CS(=O)(=O)c2ccc(C(F)(F)F)cc2)n1 CHEMBL4758299 IC50 5.0 nM
CN(C)C(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4868792 IC50 5.0 nM
CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O CHEMBL67279 Ki 5.0 nM
O=CCNC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4874501 IC50 5.4 nM
C[C@@H](NC(=O)c1ccnc2ccccc12)C(=O)N1CCC[C@H]1B(O)O CHEMBL2332619 IC50 6.4 nM
COC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4847560 IC50 6.7 nM
N#C[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL2385281 IC50 6.8 nM
N#Cc1ccc(OCc2nc(C(=O)NCC(=O)N3CC(F)(F)C[C@H]3C#N)cs2)cc1 CHEMBL4747575 IC50 7.0 nM
COC(=O)CNC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4870027 IC50 7.2 nM
O=C1c2ccccc2CN1CC(=O)N1CCC[C@H]1B(O)O CHEMBL387050 Ki 7.5 nM
COC(=O)C(NC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12)C(C)C CHEMBL4863794 IC50 8.3 nM
C[C@@H](NC(=O)c1ccncc1)C(=O)N1CCC[C@H]1B(O)O CHEMBL2333026 Ki 9.0 nM
N#Cc1ccc(S(=O)(=O)Cc2nc(C(=O)NCC(=O)N3CC(F)(F)C[C@H]3C#N)cs2)cc1 CHEMBL4789965 IC50 9.0 nM
C[C@@H](NC(=O)c1ccnc(Cl)c1)C(=O)N1CCC[C@H]1B(O)O CHEMBL2332618 IC50 9.4 nM
CC(C)[C@@H](N)C(=O)N1CCC[C@H]1B(O)O CHEMBL305170 IC50 11.0 nM
CC(C)[C@H](N)C(=O)N1CCC[C@@H]1B(O)O CHEMBL195189 IC50 11.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(CSc2ccc(C(F)(F)F)cc2)n1 CHEMBL4776967 IC50 11.0 nM
COC(=O)[C@H](CO)NC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4873662 IC50 11.0 nM
O=C(NCC(=O)N1CCC[C@H]1B(O)O)c1c(Cl)cccc1Cl CHEMBL443836 Ki 12.0 nM
N#Cc1ccc(-c2ccc(Cc3nc(C(=O)NCC(=O)N4CC(F)(F)C[C@H]4C#N)cs3)cc2)cc1 CHEMBL4753316 IC50 12.0 nM
CNC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4874657 IC50 13.0 nM
O=C(NCC(=O)N1CCC[C@H]1B(O)O)C1CCCCC1 CHEMBL387444 Ki 14.0 nM
N#Cc1ccc(Cc2nc(C(=O)NCC(=O)N3CC(F)(F)C[C@H]3C#N)cs2)cc1 CHEMBL4799823 IC50 14.0 nM
C[C@@H](NC(=O)c1ccncc1F)C(=O)N1CCC[C@H]1B(O)O CHEMBL2333029 IC50 15.0 nM
O=C(NC1CCCCC1)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4874659 IC50 15.0 nM
C[C@@H](NC(=O)c1ccnc(F)c1)C(=O)N1CCC[C@H]1B(O)O CHEMBL2332617 IC50 16.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(Cc2ccc(Br)cc2)n1 CHEMBL4746868 IC50 16.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(CS(=O)(=O)c2ccc(Cl)c(Cl)c2)n1 CHEMBL4791505 IC50 19.0 nM
O=C(NCC(=O)N1CCC[C@H]1B(O)O)C1CCCC1 CHEMBL217244 Ki 20.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H]1C[C@@H](CC(=O)N2Cc3ccccc3C2)C(=O)N1 CHEMBL1243126 IC50 20.0 nM
CS(=O)(=O)c1ccc(Cc2nc(C(=O)NCC(=O)N3CC(F)(F)C[C@H]3C#N)cs2)cc1 CHEMBL4797479 IC50 20.0 nM
Cc1ccc(S(=O)(=O)Cc2nc(C(=O)NCC(=O)N3CC(F)(F)C[C@H]3C#N)cs2)cc1 CHEMBL4759201 IC50 20.0 nM
COC(=O)[C@H](CCCCN)NC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4861885 IC50 20.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(Cc2ccc(Cl)cc2)n1 CHEMBL4789754 IC50 21.0 nM
N#Cc1ccc(CCCc2nc(C(=O)NCC(=O)N3CC(F)(F)C[C@H]3C#N)cs2)cc1 CHEMBL4781018 IC50 21.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(Cc2ccc(OC(F)(F)F)cc2)n1 CHEMBL4744633 IC50 22.0 nM
CC(=O)NCC(=O)N1CCC[C@H]1B(O)O CHEMBL217561 Ki 23.0 nM
CC(=O)NCC(=O)N1CCC[C@@H]1B(O)O CHEMBL4640030 Ki 23.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(Cc2ccc(-n3cccn3)cc2)n1 CHEMBL4742308 IC50 23.0 nM
N#Cc1ccc(SCc2nc(C(=O)NCC(=O)N3CC(F)(F)C[C@H]3C#N)cs2)cc1 CHEMBL4748680 IC50 24.0 nM
CC(C)(C)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4857711 IC50 24.0 nM
CSc1ccc(Cc2nc(C(=O)NCC(=O)N3CC(F)(F)C[C@H]3C#N)cs2)cc1 CHEMBL4762306 IC50 25.0 nM
COc1ccc(Cc2nc(C(=O)NCC(=O)N3CC(F)(F)C[C@H]3C#N)cs2)cc1 CHEMBL4748328 IC50 26.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(Cc2ccc(-n3cncn3)cc2)n1 CHEMBL4761499 IC50 28.0 nM
O=C(NCC(=O)N1CCC[C@H]1B(O)O)c1cc(Cl)ccc1Cl CHEMBL386890 Ki 29.0 nM
O=C1N[C@H](C(=O)N2CCC[C@H]2B(O)O)C[C@H]1CC(=O)N1Cc2ccccc2C1 CHEMBL1243184 IC50 31.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(Cc2cccc(Br)c2)n1 CHEMBL4755802 IC50 35.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(COc2ccc(Cl)c(Cl)c2)n1 CHEMBL4754490 IC50 35.0 nM
Cc1ccc(Cc2nc(C(=O)NCC(=O)N3CC(F)(F)C[C@H]3C#N)cs2)cc1 CHEMBL4779526 IC50 37.0 nM
O=C(CNC12CC3CC(CC(C3)C1)C2)N1CCC[C@H]1B(O)O CHEMBL460842 IC50 46.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(Cc2ccc(F)c(F)c2)n1 CHEMBL4748332 IC50 47.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(Cc2ccccc2Br)n1 CHEMBL4751873 IC50 50.0 nM
CC(C)C(=O)NCC(=O)N1CCC[C@H]1B(O)O CHEMBL216410 Ki 51.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(CCCc2ccc(Cl)c(Cl)c2)n1 CHEMBL4743736 IC50 51.0 nM
NCC(=O)N1CCC[C@H]1B(O)O CHEMBL67089 IC50 52.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H](N)CCCN1Cc2ccccc2C1=O CHEMBL1243372 IC50 54.0 nM
C[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC[C@H]1B(O)O CHEMBL2333027 IC50 54.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(Cc2cc(Cl)ccc2Cl)n1 CHEMBL4792518 IC50 55.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2Cc3ccc(F)cc3C2)C(=O)N1 CHEMBL1242940 IC50 59.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(-c2ccc(Cl)cc2C(F)(F)F)n1 CHEMBL4762435 IC50 60.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(Cc2ccc(F)cc2Cl)n1 CHEMBL4785892 IC50 60.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H]1C[C@@H](CC(=O)N2Cc3ccc(Cl)cc3C2)C(=O)N1 CHEMBL1243127 IC50 63.0 nM
CC[C@@H](NC(=O)c1ccnc2ccccc12)C(=O)N1CCC[C@H]1B(O)O CHEMBL2332622 IC50 65.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2Cc3ccc(Cl)cc3C2)C(=O)N1 CHEMBL1242939 IC50 66.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C CHEMBL237500 IC50 70.8 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2CCCC2)C(=O)N1 CHEMBL1243091 IC50 73.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(-c2ccc(C(F)(F)F)cc2)n1 CHEMBL4740030 IC50 77.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(Cc2ccccc2I)n1 CHEMBL4758377 IC50 78.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2Cc3ccccc3C2)C(=O)N1 CHEMBL1243402 IC50 79.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1ccc(F)cc1 CHEMBL3093903 IC50 82.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(-c2ccc(F)cc2)n1 CHEMBL4800379 IC50 87.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2CCc3ccccc3C2)C(=O)N1 CHEMBL1242967 IC50 88.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1coc(-c2ccc(Cl)cc2)n1 CHEMBL4797809 IC50 93.0 nM
O=C(CCC(=O)N1CCC[C@H]1B(O)O)c1ccccc1 CHEMBL217802 Ki 94.0 nM
O=C(CNC1C2CC3CC(C2)CC1C3)N1CCC[C@@H]1B(O)O CHEMBL427012 IC50 99.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1cccc(-c2ccc(Cl)cc2)n1 CHEMBL4799547 IC50 100.0 nM
Cn1cc(C(=O)NCC(=O)N2CC(F)(F)C[C@H]2C#N)cc1-c1ccc(Cl)cc1 CHEMBL4751194 IC50 104.0 nM
Cc1nc(CN2C(=O)c3c(nc(N4CCC[C@@H](N)C4)n3CC(=O)C3CC3)N3CCN=C23)nc2ccccc12 CHEMBL4464819 IC50 107.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2Cc3ccc(C(F)(F)F)cc3C2)C(=O)N1 CHEMBL1242966 IC50 110.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1cccc2ccccc12 CHEMBL2022530 Ki 110.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(CSc2ccc(Cl)c(Cl)c2)n1 CHEMBL4746891 IC50 119.0 nM
O=C(N[C@H](CO)C(=O)N1CCC[C@H]1B(O)O)c1ccnc2ccccc12 CHEMBL2332620 IC50 120.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1ccc(OCc2ccccc2)cc1 CHEMBL3093910 IC50 140.0 nM
COc1ccc(C[C@H](N)C(=O)N2C[C@@H](F)C[C@H]2C#N)cc1 CHEMBL3093905 IC50 140.0 nM
O=C(NCC(=O)N1CCC[C@H]1B(O)O)c1ccccc1 CHEMBL217753 Ki 142.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(Cc2ccc(-c3ccc(Cl)cc3)cc2)n1 CHEMBL4743815 IC50 145.0 nM
CN(CC(=O)N1CCC[C@H]1B(O)O)C(=O)C1CCC(=O)N1 CHEMBL217056 Ki 146.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(-c2ccc(Cl)cc2)n1 CHEMBL4757491 IC50 148.0 nM
O=C(CNC1CCCCCC1)N1CCC[C@H]1B(O)O CHEMBL196933 IC50 150.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1ccc(F)cc1F CHEMBL3093913 IC50 150.0 nM
O=C(NC12CC3CC(CC(C3)C1)C2)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12 CHEMBL4869363 IC50 150.0 nM
CC(=O)N(C)CC(=O)N1CCC[C@H]1B(O)O CHEMBL217754 Ki 161.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](C(=O)N2Cc3ccccc3C2)CN1 CHEMBL210995 IC50 175.0 nM
O=C(CNC1CC2CCCC1C2)N1CCC[C@H]1C(O)O CHEMBL362922 IC50 180.0 nM
CN(CC(=O)N1CCC[C@H]1B(O)O)C(=O)c1ccccc1 CHEMBL385419 Ki 191.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2CC=C(c3ccc(Cl)cc3)CC2)C(=O)N1 CHEMBL1243061 IC50 200.0 nM
N[C@H]1CO[C@H]2CC[C@@H](B(O)O)N2C1=O CHEMBL5171879 Ki 200.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@H](CC(=O)N2Cc3ccccc3C2)C(=O)N1 CHEMBL1243403 IC50 210.0 nM
COc1ccc(-c2nc(C(=O)NCC(=O)N3CC(F)(F)C[C@H]3C#N)cs2)cc1 CHEMBL4799063 IC50 214.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1ccc(F)c(F)c1F CHEMBL3091488 IC50 220.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2ccc(C(=O)O)c3ccccc23)N1 CHEMBL380090 Ki 240.0 nM
CS(=O)(=O)NCC(=O)N1CCC[C@H]1B(O)O CHEMBL217065 Ki 246.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2CCc3ccsc3C2)C(=O)N1 CHEMBL1242993 IC50 250.0 nM
CC(C)C(=O)N(C)CC(=O)N1CCC[C@H]1B(O)O CHEMBL216376 Ki 265.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1C(=O)N(Cc1nc(C)c3ccccc3n1)C1=NCCCN12 CHEMBL3675622 IC50 268.0 nM
CCCCCC12CCC(NCC(=O)N3CCC[C@H]3B(O)O)(CC1)CC2 CHEMBL372180 IC50 270.0 nM
Cc1nnc2ncc3c(n12)CN([C@H]1CC[C@H](c2cc(F)c(F)cc2F)[C@@H](N)C1)C3 CHEMBL3806023 IC50 280.0 nM
N[C@H]1C[C@@H](N2Cc3cnc4nnc(C5CC5)n4c3C2)CC[C@@H]1c1cc(F)c(F)cc1F CHEMBL3806041 IC50 280.0 nM
O=C(CNC1CCCCCCC1)N1CCC[C@H]1B(O)O CHEMBL382974 IC50 290.0 nM
CC(=O)N[C@H](C)C(=O)N1CCC[C@H]1B(O)O CHEMBL387462 Ki 350.0 nM
CSCC[C@@H](NC(=O)c1ccnc2ccccc12)C(=O)N1CCC[C@H]1B(O)O CHEMBL2332621 IC50 350.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1cc(F)c(F)cc1F CHEMBL3093914 IC50 350.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1C(=O)N(Cc1nc(C)c3ccccc3n1)C1=NCCN12 CHEMBL3675618 IC50 367.0 nM
CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(CC1=NC3C=CC=CC3C(C)=N1)c(=O)n2C CHEMBL4747683 IC50 370.0 nM
C[S+]([O-])c1ccc(Cc2nc(C(=O)NCC(=O)N3CC(F)(F)C[C@H]3C#N)cs2)cc1 CHEMBL4748662 IC50 390.0 nM
CS(=O)(=O)c1ccc(OC[C@H]2CC[C@@H](C(=O)N3CCC[C@H]3C#N)N2)c(Cl)c1 CHEMBL210805 Ki 394.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(-c2ccc(-c3ccccc3)cc2)n1 CHEMBL4755107 IC50 414.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1csc(-c2ccc3occc3c2)n1 CHEMBL4795188 IC50 446.0 nM
Cc1nc2ncc3c(n2n1)CN([C@H]1CC[C@H](c2cc(F)c(F)cc2F)[C@@H](N)C1)C3 CHEMBL3805629 IC50 450.0 nM
N#Cc1ccc(C[C@H](N)C(=O)N2C[C@@H](F)C[C@H]2C#N)cc1 CHEMBL3093907 IC50 470.0 nM
Cc1ccc(C[C@H](N)C(=O)N2C[C@@H](F)C[C@H]2C#N)cc1 CHEMBL3093904 IC50 470.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2ccccc2Cl)N1 CHEMBL377390 Ki 479.0 nM
C[C@@H](NC(=O)c1cccnc1)C(=O)N1CCC[C@H]1B(O)O CHEMBL2333028 IC50 500.0 nM
N#Cc1ccc(OC[C@H]2CC[C@@H](C(=O)N3CCC[C@H]3C#N)N2)c(Cl)c1 CHEMBL209940 Ki 505.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2CCN(c3ccc(F)cc3)CC2)C(=O)N1 CHEMBL1243028 IC50 510.0 nM
O=C(CNC1CCCCCCCCC1)N1CCC[C@H]1B(O)O CHEMBL196267 IC50 530.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1CC[C@H](COc2ccc(C(=O)O)cc2Cl)N1 CHEMBL379999 Ki 536.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1c[nH]c(-c2ccc(Cl)cc2)c1 CHEMBL4758296 IC50 550.0 nM
N[C@H]1C[C@@H](N2Cc3cnc4nc(C5CC5)nn4c3C2)CC[C@@H]1c1cc(F)c(F)cc1F CHEMBL3805346 IC50 570.0 nM
CC(C)(CC(=O)N[C@H]1C[C@@H]1c1cccc(Cl)c1)NCC(=O)N1CC(F)(F)C[C@H]1C#N CHEMBL463231 IC50 590.0 nM
N#C[C@@H]1CCCN1C(=O)CNC(=O)c1cccc2ccccc12 CHEMBL1243374 IC50 610.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1ccc(C(F)(F)F)cc1 CHEMBL3093908 IC50 610.0 nM
O=C(CNC1CCCCC1)N1CCC[C@H]1B(O)O CHEMBL371130 IC50 650.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2CCn3cc(C(F)(F)F)nc3C2)C(=O)N1 CHEMBL1242994 IC50 650.0 nM
C[C@H]1O[C@H]2CC[C@@H](B(O)O)N2C(=O)[C@H]1N CHEMBL5199424 Ki 720.0 nM
N#C[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2CCCCC2)C(=O)N1 CHEMBL1243092 IC50 730.0 nM
CC#CCn1c(N2CCNCC2)nc2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C CHEMBL3616890 IC50 740.0 nM
CC(C)(C)C(=O)NCC(=O)N1CCC[C@H]1B(O)O CHEMBL216411 Ki 751.0 nM
CC(C)=CCn1c(N2CCC[C@@H](N)C2)nc2c1C(=O)N(Cc1nc(C)c3ccccc3n1)C1=NCCN12 CHEMBL3675624 IC50 755.0 nM
CC12CC3(C)CC(C)(C1)CC(NCC(=O)N1CCC[C@@H]1B(O)O)(C2)C3 CHEMBL381444 IC50 770.0 nM
N#C[C@@H]1CC(F)(F)CN1C(=O)CNC(=O)c1cnc(-c2ccc(Cl)cc2)cn1 CHEMBL4782931 IC50 795.0 nM
N#Cc1ccc(C[C@H](N)C(=O)N2CCC[C@H]2C#N)cc1 CHEMBL3093923 IC50 800.0 nM
CC(C)c1cc(C(=O)O)ccc1OC[C@H]1CC[C@@H](C(=O)N2CCC[C@H]2C#N)N1 CHEMBL436744 Ki 888.0 nM
N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1cc(F)cc(F)c1F CHEMBL3093915 IC50 900.0 nM
CC(C)=CCn1c(N2CCC[C@H](N)C2)c(C#N)c2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C CHEMBL1951600 IC50 1000.0 nM