COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1F CHEMBL4870179 IC50 0.12 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1F CHEMBL4862823 IC50 0.17 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCCCCC(=O)NO)c4)nc3c2)c1 CHEMBL5177696 IC50 0.18 nM
CC(Oc1ccc2[nH]nc(-c3nc4cc(N5CCOCC5)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3827818 IC50 0.2 nM
COc1cc(CCc2cc(NC(=O)c3ccc(N4C[C@@H](C)N[C@@H](C)C4)cc3)n[nH]2)cc(OC)c1 CHEMBL3348846 IC50 0.2 nM
C=CC(=O)Nc1ccc(CCn2c(=O)c(-c3cc(OC)cc(OC)c3Cl)cc3cnc(NCCN4CCN(CC)CC4)nc32)cc1 CHEMBL4102642 IC50 0.2 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(N5CCN(C6CCC6)CC5)cc4)n[nH]c3n2)c1Cl CHEMBL4557949 IC50 0.2 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(N5CCN(S(C)(=O)=O)CC5)cc4)n[nH]c3n2)c1Cl CHEMBL4542061 IC50 0.2 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3nc(-c4cnn(C)c4)cnc3c2)c1 CHEMBL5189383 IC50 0.2 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCCC(=O)NO)c4)nc3c2)c1 CHEMBL5178408 IC50 0.23 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCCCC(=O)NO)c4)nc3c2)c1 CHEMBL5187998 IC50 0.24 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCOc5ccc(C(=O)NO)cc5)c4)nc3c2)c1 CHEMBL5181688 IC50 0.24 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCC(=O)NO)c4)nc3c2)c1 CHEMBL5186645 IC50 0.25 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCCCCCC(=O)NO)c4)nc3c2)c1 CHEMBL5202576 IC50 0.26 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(Cc5cccc(C(=O)NO)c5)c4)nc3c2)c1 CHEMBL5186714 IC50 0.27 nM
COc1ccc(Nc2ncc3c(n2)N(C2CCN(C(=O)/C=C/CN(C)C)CC2)C(=O)N(c2c(Cl)c(OC)cc(OC)c2Cl)C3)cc1 CHEMBL4100258 IC50 0.28 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCC(=O)NO)c4)nc3c2)c1 CHEMBL5182360 IC50 0.28 nM
C[C@@H](Oc1ccc2[nH]nc(/C=C/c3cnn(CCO)c3)c2c1)c1c(Cl)cncc1Cl CHEMBL3828009 IC50 0.3 nM
CC(Oc1ccc2[nH]nc(-c3nc4cc(NCCN(C)C)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3827492 IC50 0.3 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccccc32)c(C)c1CCC(=O)O CHEMBL274654 Kd apparent 0.3 nM
C#CC(=O)N1CCC(n2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnc32)C1 CHEMBL4461734 IC50 0.3 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(N5CCN(CCO)CC5)cc4)n[nH]c3n2)c1Cl CHEMBL4553127 IC50 0.3 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(N5CCN(C)CC5)cc4)n[nH]c3n2)c1Cl CHEMBL4469836 IC50 0.3 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(N5CCN(C(C)=O)CC5)cc4)n[nH]c3n2)c1Cl CHEMBL4447575 IC50 0.3 nM
COCCN1CCN(c2ccc(C(=O)Nc3n[nH]c4nc(-c5c(Cl)c(OC)cc(OC)c5Cl)ccc34)cc2)CC1 CHEMBL4447359 IC50 0.3 nM
C=CC(=O)Nc1ccc(/C=C/c2nc(Nc3cc(C(C)C)[nH]n3)cc(N3CCN(C)CC3)n2)cc1 CHEMBL4776177 GI50 0.3 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5cc(CN6C(C)CCC6C)ccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681271 IC50 0.32 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCCCCCCC(=O)NO)c4)nc3c2)c1 CHEMBL5191744 IC50 0.32 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCOc5ccc(C(=O)NO)cc5)c4)nc3c2)c1 CHEMBL5206740 IC50 0.35 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CCNCC5)c4)nc3c2)c1 CHEMBL3980069 pIC50 0.3631 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCCOc5ccc(C(=O)NO)cc5)c4)nc3c2)c1 CHEMBL5173348 IC50 0.37 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCc5ccc(C(=O)NO)cc5)c4)nc3c2)c1 CHEMBL5170945 IC50 0.37 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCCCOc5ccc(C(=O)NO)cc5)c4)nc3c2)c1 CHEMBL5198510 IC50 0.38 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCC(=O)Nc5ccc(C(=O)NO)cc5)c4)nc3c2)c1 CHEMBL5202912 IC50 0.38 nM
CC(Oc1ccc2[nH]nc(-c3nc4cc(N(C)C(=O)CN(C)C)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3828439 IC50 0.4 nM
C=CC(=O)N1CC(OCCn2c(=O)c(-c3c(Cl)c(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)C1 CHEMBL4099992 IC50 0.4 nM
Cc1c(-c2c3c(N)n[nH]c(=O)c3nn2-c2ccc(NC(=O)/C=C/CN(C)C)cc2)oc2ccc(Br)cc12 CHEMBL4448252 IC50 0.4 nM
CCN1C(=O)N(c2c(F)c(OC)cc(OC)c2F)Cc2cnc3[nH]c(CN4CCOCC4)cc3c21 CHEMBL4297522 IC50 0.4 nM
COc1cc(OC)c(Cl)c(CCc2cc(-c3nc4ccc(N5CCN(C)CC5)cc4[nH]3)n[nH]2)c1Cl CHEMBL5205436 IC50 0.43 nM
COc1cc(OC)cc(N(CCCN2CC(O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907314 pIC50 0.4467 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C([2H])([2H])C([2H])([2H])NC(C)C)c1 CHEMBL3918638 pIC50 0.4571 nM
COc1cc(OC)c(F)c(COc2cnc(Nc3cnn(CCO)c3)nc2)c1F CHEMBL4594428 IC50 0.47 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCNCC1 CHEMBL3924399 IC50 0.5 nM
COc1cc(C)cc2cc(-c3c(-c4cnco4)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3951786 IC50 0.5 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(C#Cc4cncc(N5CCOCC5)c4)c3)cc2C(F)(F)F)CC1 CHEMBL4091628 IC50 0.5 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(CCO)CC5)cc4)c3)c(OCCO)cc21 CHEMBL4294625 IC50 0.5 nM
CCN1CCN(c2ccc(C(=O)Nc3n[nH]c4nc(-c5c(Cl)c(OC)cc(OC)c5Cl)ccc34)cc2)CC1 CHEMBL4567187 IC50 0.5 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(N5CCNC(C)(C)C5)cc4)n[nH]c3n2)c1Cl CHEMBL5269917 IC50 0.5 nM
COc1cc(OC)cc(N(CCNS(C)(=O)=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921618 pIC50 0.5129 nM
COc1cc(OC)cc(N(CCCN2CCCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3904674 pIC50 0.5495 nM
COc1cc(OC)cc(N(CCNS(=O)(=O)N(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3919173 pIC50 0.5623 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)c(=O)n3c2)c1 CHEMBL4862576 IC50 0.57 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C)c4)c(=O)n3c2)c1 CHEMBL4859203 IC50 0.57 nM
COc1cc(OC)cc(N(CCCN2CCC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3906894 pIC50 0.5888 nM
CCN1CCN(c2ccc(Nc3cc(N(C)C(=O)Nc4c(Cl)c(OC)cc(OC)c4Cl)ncn3)cc2)CC1 CHEMBL1852688 IC50 0.59 nM
COCCNc1ccc2[nH]c(-c3n[nH]c4ccc(OC(C)c5c(Cl)cncc5Cl)cc34)nc2c1 CHEMBL3827725 IC50 0.6 nM
C=CC(=O)N1CCN(CCCn2c(=O)c(-c3c(Cl)c(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)CC1 CHEMBL4068509 IC50 0.6 nM
C=CC(=O)N1CC(n2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnc32)C1 CHEMBL4469557 IC50 0.6 nM
C=CC(=O)N1CC[C@@H](n2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnc32)C1 CHEMBL4554319 IC50 0.6 nM
C=CC(=O)N1CCC(n2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnc32)CC1 CHEMBL4441696 IC50 0.6 nM
C=CCN1CCN(c2ccc(C(=O)Nc3n[nH]c4nc(-c5c(Cl)c(OC)cc(OC)c5Cl)ccc34)cc2)CC1 CHEMBL4441872 IC50 0.6 nM
COc1cccnc1C#CCN(c1ccc2ncc(-c3cnn(C)c3)nc2c1)c1c(F)c(OC)cc(OC)c1F CHEMBL3976275 pIC50 0.6026 nM
COc1cc(OC)cc(N(Cc2cc(C)on2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3979490 pIC50 0.6166 nM
COc1cc(OC)cc(N(CCCN)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3966748 pIC50 0.6166 nM
COc1cc(OC)cc(N(CCCN)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3979013 pIC50 0.6166 nM
COc1ccnc(C#CCN(c2ccc3ncc(-c4cnn(C)c4)nc3c2)c2c(F)c(OC)cc(OC)c2F)n1 CHEMBL3978754 pIC50 0.631 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CCNCC5)c4)c(=O)n3c2)c1 CHEMBL4848334 IC50 0.65 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5cc(CN6CCCC(F)C6)ccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681272 IC50 0.67 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CCN(C(=O)OC(C)(C)C)CC5)c4)nc3c2)c1 CHEMBL3896249 pIC50 0.6761 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 IC50 0.7 nM
COc1cc(C)cc2cc(-c3c(COCC4CC4)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3909132 IC50 0.7 nM
C=CC(=O)NCCCCn1c(=O)c(-c2c(Cl)c(OC)cc(OC)c2Cl)cc2cnc(NC)nc21 CHEMBL4083740 IC50 0.7 nM
C=CC(=O)N1CCCC(OCCn2c(=O)c(-c3c(Cl)c(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)C1 CHEMBL4061766 IC50 0.7 nM
COc1cc(OC)cc(-c2nn(CCCCCN3CCN(C(=O)/C=C/C(F)(F)F)CC3)c3ncnc(N)c23)c1 CHEMBL5088737 IC50 0.7 nM
COc1cc(OC)cc(N(CCCN2CCC(N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3919730 pIC50 0.7244 nM
CNc1ncc2c(n1)N(C1CCN(C(=O)/C=C/CN(C)C)CC1)C(=O)N(c1c(Cl)c(OC)cc(OC)c1Cl)C2 CHEMBL4092354 IC50 0.73 nM
COc1cc(CCc2cc(-c3nc4ccc(N5CCN(C)CC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5199374 IC50 0.75 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3918092 pIC50 0.7586 nM
COc1cc(OC)cc(N(CC2COCC(C)(C)N2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3901119 pIC50 0.7586 nM
COc1cc(OC)cc(N(CCCNC(=O)C(F)(F)F)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3983918 pIC50 0.7586 nM
CCn1cc(-c2cnc3ccc(N(CCNC(C)C)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3945159 pIC50 0.7762 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCN)c4)nc3c2)c1 CHEMBL3921817 pIC50 0.7762 nM
COc1cc(OC)c(F)c(N2Cc3cnc4c(c3N(C)C2=O)C2(CC2)C(=O)N4)c1F CHEMBL4846809 IC50 0.79 nM
COc1cc(OC)c(Cl)c(CCc2cc(-c3nc4ccc(CN5CCN(C)CC5)cc4[nH]3)n[nH]2)c1Cl CHEMBL5177815 IC50 0.79 nM
CC(Oc1ccc2[nH]nc(-c3nc4cc(N5CCC(N6CCCCC6)CC5)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3828465 IC50 0.8 nM
C=CC(=O)Nc1ccc(CCn2c(=O)c(-c3cc(OC)cc(OC)c3Cl)cc3cnc(NCCN4CCN(C)CC4)nc32)cc1 CHEMBL4086567 IC50 0.8 nM
C=CC(=O)Nc1ccc(CCn2c(=O)c(-c3cc(OC)cc(OC)c3Cl)cc3cnc(NC(CO)CO)nc32)cc1 CHEMBL4073347 IC50 0.8 nM
C=CC(=O)Nc1ccc(-n2nc3c(=O)[nH]nc(N)c3c2-c2oc3ccc(Cl)cc3c2C)cc1 CHEMBL4467025 IC50 0.8 nM
COc1cc(C)cc2cc(-c3cn(C4CCN(C(=O)/C=C/CN(C)C)C4)c4ncnc(N)c34)sc12 CHEMBL4444412 IC50 0.8 nM
CCC(=O)N1CCC(n2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnc32)C1 CHEMBL4552123 IC50 0.8 nM
C=CC(=O)N1CC(n2cc(-c3cc4cccc(OC)c4s3)c3c(N)ncnc32)C1 CHEMBL4558466 IC50 0.8 nM
C=CC(=O)N1CCC(n2cc(-c3cc4cccc(OC)c4s3)c3c(N)ncnc32)C1 CHEMBL4580623 IC50 0.8 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(OCC6(C)COC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3676325 IC50 0.81 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CCN(C(C)=O)CC5)c4)c(=O)n3c2)c1 CHEMBL4849539 IC50 0.82 nM
COc1cc(OC)cc(N(Cc2csc(C)n2)c2ccc3ncc(-c4cnn(CCN5CCNCC5)c4)nc3c2)c1 CHEMBL3921197 pIC50 0.8318 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3931421 pIC50 0.8511 nM
CCS(=O)(=O)NCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3912569 pIC50 0.871 nM
[2H]C([2H])([2H])n1cc(-c2cnc3ccc(N(CCNC(C)C)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3919709 pIC50 0.871 nM
COc1cc(OC)cc(N(CCCN2CCC[C@@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3942763 pIC50 0.8913 nM
CCN1CCN(c2ccc(Nc3cc(N(C)C(=O)Nc4c(Cl)c(OC)cc(OC)c4Cl)ncn3)cc2)CC1 CHEMBL1834657 IC50 0.9 nM
C[C@@H](Oc1ccc2[nH]nc(-c3nc4cc(N5CCN(C)CC5)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3827178 IC50 0.9 nM
COCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCNCC1 CHEMBL3892887 IC50 0.9 nM
COc1cc(C)cc2cc(-c3c(COCCO)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3895503 IC50 0.9 nM
COc1cc(C)cc2cc(-c3c(COC4CCC4)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3979384 IC50 0.9 nM
C=C(CN(C)C)C(=O)N1CCC(n2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnc32)C1 CHEMBL4557987 IC50 0.9 nM
C#CC(=O)N1CCC(n2nc3c(=O)[nH]nc(N)c3c2-c2oc3ccc(C)cc3c2C)CC1 CHEMBL5271701 IC50 0.9 nM
COc1ccccc1Nc1ncc2c(n1)N(C1CCN(C(=O)/C=C/CN(C)C)CC1)C(=O)N(c1c(Cl)c(OC)cc(OC)c1Cl)C2 CHEMBL4077029 IC50 0.91 nM
[2H]C([2H])([2H])Oc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3975791 pIC50 0.912 nM
COc1cc(O)cc(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3964096 pIC50 0.912 nM
C#CCN(c1ccc2ncc(-c3cnn(C)c3)nc2c1)c1c(F)c(OC)cc(OC)c1F CHEMBL3935597 pIC50 0.9333 nM
CNCCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3968499 pIC50 0.955 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(CCCN)c4)nc3c2)c1 CHEMBL3927875 pIC50 0.9772 nM
COc1cc(OC)cc(N(CCCN2CCC(F)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3975447 pIC50 0.9772 nM
COc1cc(OC)cc(N(CCC(=O)NCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3937972 pIC50 0.9772 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(F)cc4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4092508 IC50 0.99 nM
CC(C)(C)NC(=O)Nc1ccc2[nH]nc(-c3nc4cc(N5CCC(N6CCCCC6)CC5)ccc4[nH]3)c2c1 CHEMBL378024 IC50 1.0 nM
CN1CCN(c2cccc3[nH]c(=O)c(-c4nc5ccccc5[nH]4)c(N)c23)CC1 CHEMBL498551 IC50 1.0 nM
CN1CCCC(Oc2cccc3[nH]c(=O)c(-c4nc5ccccc5[nH]4)c(N)c23)C1 CHEMBL495749 IC50 1.0 nM
COc1cc(CCc2cc(Nc3ncnc4cc(N5CCN6CCCCC6C5)ccc34)n[nH]2)cc(OC)c1 CHEMBL3800526 IC50 1.0 nM
CC(Oc1ccc2[nH]nc(-c3nc4cc(C5CCN(C)CC5)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3827268 IC50 1.0 nM
CC(Oc1ccc2[nH]nc(-c3nc4cc(N5CCN(C)CC5)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3828740 IC50 1.0 nM
COc1cc(OC)cc(N(CCCN2CCC[C@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3936672 pIC50 1.0 nM
COc1cc(OC)cc(N(CCCNCC(N)=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3960877 pIC50 1.0 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CC[C@](C)(N)C1 CHEMBL3985178 IC50 1.0 nM
COc1cc(C)cc2cc(-c3c(COCC(N)=O)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3926373 IC50 1.0 nM
COc1cc(C)cc2cc(-c3c(CNC(C)=O)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3934668 IC50 1.0 nM
C=CC(=O)Nc1ccc(CN2C(=O)N(c3cc(OC)cc(OC)c3)Cc3cnc(Nc4ccc(N5CCN(C)CC5)cc4)nc32)cc1 CHEMBL4065323 IC50 1.0 nM
C=CC(=O)Nc1ccc(CN(C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c2cc(Nc3ccc(N4CCN(C)CC4)cc3)ncn2)cc1 CHEMBL4092990 IC50 1.0 nM
C=CC(=O)Nc1ccc(CCn2c(=O)c(-c3cc(OC)cc(OC)c3Cl)cc3cnc(NCCO)nc32)cc1 CHEMBL4092456 IC50 1.0 nM
C=CC(=O)N1CC(N(C)CCn2c(=O)c(-c3c(Cl)c(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)C1 CHEMBL4089842 IC50 1.0 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(N5CCN(C)CC5)cc4)c3)ccc12 CHEMBL4290371 IC50 1.0 nM
CCCn1cc(-c2cnc3ccc(N(CCNC(C)C)c4cc(OC)cc(OC)c4)cn3c2=O)cn1 CHEMBL4872440 IC50 1.0 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CCN(S(C)(=O)=O)CC5)c4)c(=O)n3c2)c1 CHEMBL4869917 IC50 1.0 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C5CCNCC5)c4)nc3c2)c1 CHEMBL3969446 pIC50 1.023 nM
COc1cc(OC)cc(N(Cc2ncc[nH]2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3928393 pIC50 1.023 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCCN)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3942328 pIC50 1.023 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCCN4CCCC4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3972979 pIC50 1.047 nM
COc1cc(OC)cc(N(C[C@@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(CCCN)c4)nc3c2)c1 CHEMBL3964701 pIC50 1.047 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4096041 IC50 1.06 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4088313 IC50 1.06 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(NC(C)C)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4069509 IC50 1.07 nM
COc1cc(OC)cc(N(CCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3985222 pIC50 1.072 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3955563 pIC50 1.072 nM
COc1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3951694 pIC50 1.096 nM
COc1cc(OC)cc(N(CCCNC(=O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3891892 pIC50 1.096 nM
COc1cc(OC)cc(N(CCCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3909529 pIC50 1.096 nM
COc1cc(C)cc2cc(-c3c(CNCCO)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3905236 IC50 1.1 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cncc2c1ccn2C CHEMBL4067760 IC50 1.1 nM
CN1CCN(Cc2ccc(NC(=O)c3cccc(C#Cc4cncc5ccccc45)c3)cc2C(F)(F)F)CC1 CHEMBL4081243 IC50 1.1 nM
C=CC(=O)Nc1ccc(CCn2c(=O)c(-c3cc(OC)cc(OC)c3Cl)cc3cnc(NCCN4CCN(C(C)=O)CC4)nc32)cc1 CHEMBL4084708 IC50 1.1 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1Cl CHEMBL4863146 IC50 1.1 nM
COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1 CHEMBL4863224 IC50 1.1 nM
CCn1cc(-c2cnc3ccc(N(CCN)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3950089 pIC50 1.122 nM
COc1cc(OC)cc(N(CCCN2CCCCC2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3905485 pIC50 1.148 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4cccc(C)c4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4103795 IC50 1.16 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(C5CCCCO5)c4)nc3c2)c1 CHEMBL3980232 pIC50 1.175 nM
COc1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cnn(CC5CCOCC5)c4)nc3c2)c1 CHEMBL3966305 pIC50 1.175 nM
COc1cc(OC)cc(N(C[C@@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3913322 pIC50 1.175 nM
COc1cc(OC)cc(N(CCCNC(C)(C)CF)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921469 pIC50 1.175 nM
COc1cccc(Nc2ncc3c(n2)N(C2CCN(C(=O)/C=C/CN(C)C)CC2)C(=O)N(c2c(Cl)c(OC)cc(OC)c2Cl)C3)c1 CHEMBL4068733 IC50 1.18 nM
C=CC(=O)N1CC(N2C=C(C#Cc3cc(OC)cc(OC)c3)C3C(N)=NC=NC32)C1 CHEMBL3701266 IC50 1.2 nM
C[C@@H](Oc1ccc2[nH]nc(-c3nc4cc(CCO)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3827330 IC50 1.2 nM
Nc1c(C(=O)c2cc3cc(CN4CCOCC4)ccc3[nH]2)cnn1-c1cc(O)ccc1Cl CHEMBL3984621 IC50 1.2 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cncc2ccccc12 CHEMBL4105491 IC50 1.2 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(N5CCOCC5)cc4)c3)ccc12 CHEMBL4282503 IC50 1.2 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(CCO)CC5)cc4)c3)ccc12 CHEMBL4288908 IC50 1.2 nM
C=CC(=O)Nc1ccc(-n2nc3c(=O)[nH]nc(N)c3c2-c2oc3ccc(C)cc3c2C)cc1 CHEMBL4446835 IC50 1.2 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3545376 IC50 1.2 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCF)c4)c(=O)n3c2)c1 CHEMBL4872664 IC50 1.2 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CCCCO5)c4)c(=O)n3c2)c1 CHEMBL4871676 IC50 1.2 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCN(C)C)c4)c(=O)n3c2)c1 CHEMBL4863732 IC50 1.2 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCN5CCOCC5)c4)c(=O)n3c2)c1 CHEMBL4873837 IC50 1.2 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CNC5)c4)c(=O)n3c2)c1 CHEMBL4845884 IC50 1.2 nM
COc1cc(OC)cc(N(CCCN)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3922698 pIC50 1.202 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4cccc(F)c4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4079538 IC50 1.21 nM
COc1cc(OC)cc(N(CCN2CCCCC2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3943043 pIC50 1.23 nM
[2H]C([2H])([2H])Oc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3981418 pIC50 1.23 nM
COc1cc(OC)cc(N(CCNS(=O)(=O)C(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3964574 pIC50 1.23 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCOC4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4096738 IC50 1.23 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCC5CCNCC5)c4)nc3c2)c1 CHEMBL3925306 pIC50 1.259 nM
COc1cc(F)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3918739 pIC50 1.259 nM
COc1cc(OC)cc(N(CCC2CCN(C(C)C)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3970423 pIC50 1.259 nM
COc1cc(OC)cc(N(CCCN2CCC(S(C)(=O)=O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3933707 pIC50 1.259 nM
COc1cc(OC)cc(N(CCC(C)(C)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3950910 pIC50 1.259 nM
CCCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCNCC1 CHEMBL3907995 IC50 1.3 nM
COc1cc(C)cc2cc(-c3c(COC(C)C)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3918062 IC50 1.3 nM
COc1cc(C)cc2cc(-c3c(CN4CCNC(=O)C4)c(Cl)n4ncnc(N)c34)sc12 CHEMBL3937124 IC50 1.3 nM
CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnn(C)c4)cnc32)c1 CHEMBL3956762 IC50 1.3 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(F)c(C#Cc4cncc5ccccc45)c3)cc2C(F)(F)F)CC1 CHEMBL4086643 IC50 1.3 nM
C=CC(=O)Nc1ccc(CCn2c(=O)c(-c3cc(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)cc1 CHEMBL4099578 IC50 1.3 nM
C=CC(=O)Nc1ccc(CCn2c(=O)c(-c3cc(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)cn1 CHEMBL4061286 IC50 1.3 nM
C=CC(=O)Nc1ccc(CCn2c(=O)c(-c3cc(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)nc1 CHEMBL4083151 IC50 1.3 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CCN(C)CC5)c4)c(=O)n3c2)c1 CHEMBL4876247 IC50 1.3 nM
COc1cc(OC)cc(N(CCCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3934260 pIC50 1.318 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCOCC4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4060079 IC50 1.32 nM
COc1cc(OC)cc(N(CCCN2CCC(O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3984039 pIC50 1.349 nM
COc1cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)cc2c1OCO2 CHEMBL3896142 pIC50 1.349 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C(C)CN)c1 CHEMBL3976752 pIC50 1.349 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCCN)c4)nc3c2)c1 CHEMBL3898120 pIC50 1.38 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC(=O)NCCN5CCCC5)c4)nc3c2)c1 CHEMBL3951714 pIC50 1.38 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3970430 pIC50 1.38 nM
COc1cc(OC)cc(N(Cc2nnc(N)o2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3968009 pIC50 1.38 nM
COc1cc(OC)cc(N(CCNCC(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3905866 pIC50 1.38 nM
COc1cc(OC)c(F)c(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1F CHEMBL3903973 pIC50 1.38 nM
COc1cc(OC)c(F)c(N(CCCNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1F CHEMBL3892529 pIC50 1.38 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCC#N)c4)nc3c2)c1 CHEMBL3958209 pIC50 1.38 nM
C#CC(=O)N1CC[C@H](n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701239 IC50 1.4 nM
CC(Oc1ccc2[nH]nc(-c3nc4cc(N5C[C@@H](C)N[C@@H](C)C5)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3828122 IC50 1.4 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(CN6CCOCC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681278 IC50 1.4 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5cc(CN6CCCC6)ccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681292 IC50 1.4 nM
COCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CC[C@](C)(N)C1 CHEMBL3938823 IC50 1.4 nM
COc1cc(C)cc2cc(-c3c(CNC(C)=O)c(CNC(C)=O)n4ncnc(N)c34)sc12 CHEMBL3929322 IC50 1.4 nM
COc1cc(C)cc2cc(-c3c(CNCC(C)(C)O)c(C)n4ncnc(N)c34)sc12 CHEMBL3906839 IC50 1.4 nM
C=CC(=O)Nc1ccc(CCn2c(=O)c(-c3cc(OC)cc(OC)c3Cl)cc3cnc(NCCN4CCOCC4)nc32)cc1 CHEMBL4064081 IC50 1.4 nM
C=CC(=O)NC1CCC(n2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnc32)CC1 CHEMBL4564948 IC50 1.4 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(N5CCN(C(C)C)CC5)cc4)n[nH]c3n2)c1Cl CHEMBL4576419 IC50 1.4 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CC(C)(C)O)c4)c(=O)n3c2)c1 CHEMBL4873997 IC50 1.4 nM
COc1cc(OC)cc(N(CCNC2CC2)c2ccc3ncc(-c4cnn(C)c4)c(=O)n3c2)c1 CHEMBL4860678 IC50 1.4 nM
COc1cc(OC)cc(N(Cc2cc(C)no2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3898908 pIC50 1.413 nM
COc1cc(OC)cc(N(CCCN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3937633 pIC50 1.413 nM
COc1cc(OC)cc(N(CCN2CCC(N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3983996 pIC50 1.413 nM
CNC1CCN(CCCN(c2cc(OC)cc(OC)c2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)C1 CHEMBL3922453 pIC50 1.413 nM
COc1cc(OC)cc(N(CCCN2CCC[C@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3949132 pIC50 1.413 nM
COc1cc(OC)cc(N(CCC2CCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3915268 pIC50 1.413 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C(C)CNC(C)C)c1 CHEMBL3942606 pIC50 1.413 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CCN(C)CC5)c4)nc3c2)c1 CHEMBL3917908 pIC50 1.413 nM
COc1cc(OC)cc(N(CCN(C)C(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3908707 pIC50 1.413 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3892018 pIC50 1.445 nM
COc1cc(OC)cc(N(CC(O)CNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3978453 pIC50 1.445 nM
COc1cc(OC)cc(N(CC#CC(C)(C)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3924172 pIC50 1.445 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCCNC(C)C)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3925114 pIC50 1.479 nM
CC(Oc1ccc2[nH]nc(-c3nc4cc(CCO)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3827180 IC50 1.5 nM
COC(=O)COCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCNCC1 CHEMBL3938826 IC50 1.5 nM
C=CC(=O)Nc1ccc(CCn2c(=O)c(-c3cc(OC)cc(OC)c3Cl)cc3cnc(NCCCN4CCOCC4)nc32)cc1 CHEMBL4064756 IC50 1.5 nM
C=CC(=O)N1CCC(N(C)CCn2c(=O)c(-c3c(Cl)c(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)CC1 CHEMBL4095844 IC50 1.5 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1 CHEMBL1946170 IC50 1.5 nM
COc1cc(OC)c(F)c(N2Cc3cnc4c(c3N(c3cccc(F)c3F)C2=O)CC(=O)N4)c1F CHEMBL4851637 IC50 1.5 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CCOCC5)c4)c(=O)n3c2)c1 CHEMBL4850483 IC50 1.5 nM
COc1cc(OC)cc(N(CCN2CCC(O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3959345 pIC50 1.514 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CC5CCOCC5)c4)nc3c2)c1 CHEMBL3926082 pIC50 1.514 nM
CCCn1cc(-c2cnc3ccc(N(CCN)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3959573 pIC50 1.514 nM
COc1cc(OC)cc(N(CC(C)NC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3945277 pIC50 1.514 nM
COc1cc(OC)cc(N(CCC#N)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3913757 pIC50 1.549 nM
COc1cc(OC)cc(N(CCN2CCCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3957264 pIC50 1.549 nM
COc1cc(OC)cc(N(CCN2CCC[C@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3943860 pIC50 1.549 nM
COc1cc(OC)cc(N(CCN(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3952277 pIC50 1.549 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCN5CCN(CCO)CC5)c4)nc3c2)c1 CHEMBL3957473 pIC50 1.549 nM
COc1cc(OC)cc(N(CC#CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3895267 pIC50 1.549 nM
COc1cc(OC)cc(N(CC(=O)Nc2cc(O)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3894762 pIC50 1.549 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3cc(F)c4[nH]c(C)cc4c3)csc12 CHEMBL2006778 pKi 1.585 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC5CCN(C)CC5)c4)nc3c2)c1 CHEMBL3948321 pIC50 1.585 nM
COc1cc(OC)cc(N(CCCN2CCC(N3CCCCC3)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3971277 pIC50 1.585 nM
COc1cc(OC)cc(N(CCn2cccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3933341 pIC50 1.585 nM
COc1cc(OC)cc(N(CCCNCC(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3934080 pIC50 1.585 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4C)nc3c2)c1 CHEMBL3966071 pIC50 1.585 nM
COc1cc(OC)c(Cl)c(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1Cl CHEMBL3979328 pIC50 1.585 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5cc(CN6CCN(C)CC6)ccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681291 IC50 1.6 nM
COc1cc(C)cc2cc(-c3c(COCC(F)(F)F)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3889953 IC50 1.6 nM
COc1cc(C)cc2cc(-c3c(CNC(C)=O)c(CN4CCN(C(C)=O)CC4)n4ncnc(N)c34)sc12 CHEMBL3938513 IC50 1.6 nM
CN1CCN(Cc2ccc(NC(=O)c3cncc(C#Cc4cncc5ccccc45)c3)cc2C(F)(F)F)CC1 CHEMBL4062884 IC50 1.6 nM
C=CC(=O)Nc1cccc(CCn2c(=O)c(-c3cc(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)n1 CHEMBL4066763 IC50 1.6 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCNCC5)cc4)c3)ccc12 CHEMBL4289296 IC50 1.6 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CN(C(C)=O)C5)c4)c(=O)n3c2)c1 CHEMBL4866204 IC50 1.6 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CN(S(C)(=O)=O)C5)c4)c(=O)n3c2)c1 CHEMBL4867685 IC50 1.6 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3961210 pIC50 1.622 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CC(=O)NC)c3)nc2c1 CHEMBL3935232 pIC50 1.622 nM
CCN(CC)CCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3916975 pIC50 1.622 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3940175 pIC50 1.622 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(CCCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921441 pIC50 1.622 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC5(O)CCNCC5)c4)nc3c2)c1 CHEMBL3911573 pIC50 1.66 nM
COc1cc(OC)cc(N(CCN2CCCC2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3969815 pIC50 1.66 nM
COc1cc(F)cc(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3974206 pIC50 1.66 nM
COc1cc(OC)cc(N(CC#Cc2cc(N)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3902961 pIC50 1.66 nM
COc1cc(OC)cc(N(CCC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3951126 pIC50 1.698 nM
COc1cc(OC)cc(N(CCCNC(=O)C(C)(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3935825 pIC50 1.698 nM
COc1cc(OC)cc(N(CCCNC(=O)C(C)(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3897101 pIC50 1.698 nM
COc1cc(OC)cc(N(CCNC(=O)C(C)(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3899692 pIC50 1.698 nM
c1cncc(COc2ccc3[nH]nc(-c4nc5cc(N6CCCCC6)ccc5[nH]4)c3c2)c1 CHEMBL3827145 IC50 1.7 nM
COc1cc(C)cc2cc(-c3c(CNCC4CC4)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3952635 IC50 1.7 nM
CCC(=O)N1CCC(Cn2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnc32)C1 CHEMBL4438069 IC50 1.7 nM
COc1cc(Nc2ncc(CCc3c(F)c(OC)cc(OC)c3F)cn2)ccc1N1CCC(N2CCN(C)CC2)CC1 CHEMBL4763773 IC50 1.7 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3918751 pIC50 1.738 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3898355 pIC50 1.738 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CC(=O)NC)c3)nc2c1 CHEMBL3909140 pIC50 1.738 nM
CNC[C@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3968124 pIC50 1.738 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3893786 pIC50 1.738 nM
COc1cc(OC)cc(N(CCNCCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3944610 pIC50 1.738 nM
COc1cc(OC)cc(N(CCCN2CC=CCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3919479 pIC50 1.738 nM
COc1cc(OC)cc(N(CCCN2CCCC2(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3968818 pIC50 1.738 nM
COCC(O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C(C)C)c3)nc2c1 CHEMBL3984461 pIC50 1.738 nM
COCC(O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C(C)C)c3)nc2c1 CHEMBL3981955 pIC50 1.738 nM
CNc1ncc2c(n1)N(CCCNC(=O)/C=C/CN(C)C)C(=O)N(c1c(Cl)c(OC)cc(OC)c1Cl)C2 CHEMBL4102560 IC50 1.77 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCO)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3909565 pIC50 1.778 nM
COc1cc(OC)cc(N(Cc2csc(C)n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3961872 pIC50 1.778 nM
COc1cc(OC)cc(N(CCNC2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3923296 pIC50 1.778 nM
COc1cc(OC)cc(N(CCN2CCC[C@@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3954671 pIC50 1.778 nM
COc1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3941700 pIC50 1.778 nM
CCc1c(-c2cnc3ccc(N(CCNC(C)C)c4cc(OC)cc(OC)c4)cc3n2)cnn1C CHEMBL3918426 pIC50 1.778 nM
COc1cc(OC)cc(N(CC#Cc2cc(C(N)=O)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921190 pIC50 1.778 nM
COc1cc(OC)c(F)c(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1F CHEMBL3954396 pIC50 1.778 nM
CNC(=O)c1ncc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(CCO)CC4)c(C(F)(F)F)c3)ccc2C)n1C CHEMBL1784637 IC50 1.8 nM
CC(Oc1ccc2[nH]nc(-c3nc4ccccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3827659 IC50 1.8 nM
CC(=O)N1CCN(Cc2ccc3cc(C(=O)c4cnn(-c5ccc6[nH]c(C)nc6c5)c4N)[nH]c3c2)CC1 CHEMBL3681290 IC50 1.8 nM
CC(=O)Nc1cc(-n2cccc2)cc(-n2cnc3cc(-c4cn(CCC(C)(C)O)nn4)ccc32)c1 CHEMBL3942773 IC50 1.8 nM
C=CC(=O)N1CCC(OCCn2c(=O)c(-c3c(Cl)c(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)C1 CHEMBL4081984 IC50 1.8 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(N5CCN(CCO)CC5)cc4)c3)ccc12 CHEMBL4278642 IC50 1.8 nM
C=CC(=O)N1CC[C@H](n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701238 IC50 1.8 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4cc(F)cc(F)c4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4066038 IC50 1.81 nM
COCCn1cc(-c2cnc3ccc(N(Cc4cc(C)no4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3985692 pIC50 1.82 nM
COc1cc(OC)cc(N(CCCN2CCC(OC)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3972517 pIC50 1.82 nM
COc1cc(OC)c(Cl)c(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3892135 pIC50 1.82 nM
COc1cc(OC)cc(N(CCNC(C)=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3945373 pIC50 1.82 nM
COc1cc(OC)cc(N(CCN2CCC(N(C)C)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3958708 pIC50 1.82 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3947189 pIC50 1.82 nM
COc1cc(OC)cc(N(CCN2CCCC(C(N)=O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3931790 pIC50 1.82 nM
COc1cc(OC)cc(N(Cc2nccn2S(=O)(=O)N(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3889711 pIC50 1.82 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4CO)nc3c2)c1 CHEMBL3932022 pIC50 1.82 nM
COc1cc(OC)cc(N(Cc2cc(C)no2)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3951245 pIC50 1.862 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC5CCNCC5)c4)nc3c2)c1 CHEMBL3976280 pIC50 1.862 nM
COc1cc(OC)c(Cl)c(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3922586 pIC50 1.862 nM
COc1cc(OC)cc(N(CC(F)CN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3908149 pIC50 1.862 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)[C@H]2CC[C@@H](NC(C)C)CC2)c1 CHEMBL3911621 pIC50 1.862 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C5CCNCC5)c4)nc3c2)c1 CHEMBL3897783 pIC50 1.862 nM
COc1cc(OC)cc(N(CCCNCCC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3899151 pIC50 1.862 nM
COc1cc(C)cc2cc(-c3c(CNCC(C)(C)O)c(Cl)n4ncnc(N)c34)sc12 CHEMBL3911335 IC50 1.9 nM
C=CC(=O)Nc1cc(CCn2c(=O)c(-c3cc(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)ccn1 CHEMBL4088057 IC50 1.9 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(N5CC(C)OC(C)C5)cc4)c3)ccc12 CHEMBL4282107 IC50 1.9 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1 CHEMBL4847441 IC50 1.9 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4)c(=O)n3c2)c1 CHEMBL4849522 IC50 1.9 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC(O)CN5CCCCC5)c4)nc3c2)c1 CHEMBL3964675 pIC50 1.905 nM
COc1cc(OC)c(C)c(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3932285 pIC50 1.905 nM
COc1cc(OC)cc(N(C[C@@H](O)CNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3903811 pIC50 1.905 nM
COc1cc(OC)c(Cl)c(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1Cl CHEMBL3978617 pIC50 1.905 nM
COc1cc(OC)cc(N(CC#Cc2ccnc(N)n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3964043 pIC50 1.905 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3898881 pIC50 1.95 nM
COc1cc(OC)cc(N(C[C@@H]2CCCN2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3979170 pIC50 1.95 nM
CNC(=O)c1cc(F)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3944438 pIC50 1.95 nM
COc1cc(OC)cc(N(CCN2CCC(CO)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3917141 pIC50 1.95 nM
COc1cc(OC)cc(N(CCNCCF)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3960571 pIC50 1.95 nM
CNC(=O)c1cc(F)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3946103 pIC50 1.95 nM
COc1cc(OC)cc(N(C[C@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(CCCN)c4)nc3c2)c1 CHEMBL3950510 pIC50 1.95 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(F)c(Cl)c4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4072483 IC50 1.97 nM
COc1cc(CCc2cc(Nc3ccnc(NCc4cc(C)no4)n3)n[nH]2)cc(OC)c1 CHEMBL2088096 IC50 1.99 nM
COc1cc(CCc2cc(Nc3ccnc(NCc4cc(C)on4)n3)n[nH]2)cc(OC)c1 CHEMBL2088260 pIC50 1.995 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC5(OC)CCNCC5)c4)nc3c2)c1 CHEMBL3908326 pIC50 1.995 nM
CNC(=O)Cn1cc(-c2ccc3ncc(N(CCN)c4cc(OC)cc(OC)c4)nc3c2)cn1 CHEMBL3976053 pIC50 1.995 nM
CNC[C@@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3965710 pIC50 1.995 nM
COc1cc(OC)cc(N(CCN2CCC(CCO)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3973929 pIC50 1.995 nM
COc1cc(OC)cc(N(CCCN2CCC[C@@H]2CC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3948744 pIC50 1.995 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C5CCN(C)CC5)c4)nc3c2)c1 CHEMBL3967761 pIC50 1.995 nM
FC(F)(F)c1ccc2c(-c3nc4cc(N5CCC(N6CCCCC6)CC5)ccc4[nH]3)[nH]nc2c1 CHEMBL377230 IC50 2.0 nM
CN1CCN(c2ccc3[nH]c(-c4c(N)c5c(Cl)cccc5[nH]c4=O)nc3c2)CC1 CHEMBL495762 IC50 2.0 nM
Cc1ccc2[nH]c(-c3n[nH]c4ccc(OC(C)c5c(Cl)cncc5Cl)cc34)nc2c1 CHEMBL3827387 IC50 2.0 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5cc(C(=O)N6CCN(C)CC6)ccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681280 IC50 2.0 nM
COc1cc(CCc2cc(NC(=O)c3ccc(N4CC(C)NC(C)C4)cc3)n[nH]2)cc(OC)c1 CHEMBL3184679 Kd apparent 2.0 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(N5CCNC(C)C5)cc4)c3)ccc12 CHEMBL4292708 IC50 2.0 nM
C=CC(=O)N1CC(n2cc(-c3cc4cc(OC)ccc4s3)c3c(N)ncnc32)C1 CHEMBL4575973 IC50 2.0 nM
COCCn1cc(-c2cnc3ccc(N(CCNC(C)C)c4cc(OC)cc(OC)c4)cn3c2=O)cn1 CHEMBL4852671 IC50 2.0 nM
C=CC(=O)N1CCC(n2nc3c(=O)[nH]nc(N)c3c2-c2oc3ccc(Cl)cc3c2C)CC1 CHEMBL5270198 IC50 2.0 nM
C#CCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3900620 pIC50 2.042 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C(C)C)c3)nc2c1 CHEMBL3896052 pIC50 2.042 nM
COc1cc(OC)cc(N(CCN2CCC[C@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907195 pIC50 2.042 nM
COc1cc(OC)cc(N(CCCN2[C@H](C)CC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3902353 pIC50 2.042 nM
COc1cc(OC)cc(N(CCCN2CCC[C@H]2CC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921476 pIC50 2.042 nM
COc1cc(Cl)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3965614 pIC50 2.089 nM
COc1cc(OC)cc(N(Cc2csc(C)n2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3929914 pIC50 2.089 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)[C@H](C)CN)c1 CHEMBL3957414 pIC50 2.089 nM
COC[C@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CCCN)c3)nc2c1 CHEMBL3916200 pIC50 2.089 nM
CC(Oc1ccc2[nH]nc(-c3nc4cc(F)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3827601 IC50 2.1 nM
CNc1ccc2[nH]c(-c3n[nH]c4ccc(OC(C)c5c(Cl)cncc5Cl)cc34)nc2c1 CHEMBL3828649 IC50 2.1 nM
COCCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCNCC1 CHEMBL3984301 IC50 2.1 nM
COc1cc(C)cc2cc(-c3c(CN4CCCC(O)C4)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3929725 IC50 2.1 nM
COc1cc(C)cc2cc(-c3c(CNC4CCC4)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3969060 IC50 2.1 nM
C=CC(=O)Nc1cnc(CCn2c(=O)c(-c3cc(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)cn1 CHEMBL4084079 IC50 2.1 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(N5C[C@@H](C)N[C@@H](C)C5)cc4)c3)ccc12 CHEMBL4276742 IC50 2.1 nM
C=CC(=O)N1CCC(n2cc(-c3cc4cccc(C)c4s3)c3c(N)ncnc32)C1 CHEMBL4471530 IC50 2.1 nM
CCNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)ncc1NC(=O)c1cc(OC)cc(OC)c1 CHEMBL4642080 IC50 2.1 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)c(=O)n3c2)c1 CHEMBL4852018 IC50 2.1 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCCO)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3954298 pIC50 2.138 nM
COc1cc(F)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3950069 pIC50 2.138 nM
COc1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3987037 pIC50 2.188 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCN5CCNCC5)c4)nc3c2)c1 CHEMBL3985853 pIC50 2.188 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCN5CCN(CCO)CC5)c4)nc3c2)c1 CHEMBL3937533 pIC50 2.188 nM
CCNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3939278 pIC50 2.188 nM
COc1cc(OC)c(C)c(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3945264 pIC50 2.188 nM
COc1cc(OC)cc(N(Cc2cn(CCO)nn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921457 pIC50 2.188 nM
COc1cc(OC)cc(N(CC2COCCN2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3919884 pIC50 2.188 nM
COc1cc(OC)cc(N(C[C@@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3905276 pIC50 2.188 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCN5CCN(CCCO)CC5)c4)nc3c2)c1 CHEMBL3951171 pIC50 2.188 nM
CN1CCN(Cc2ccc(NC(=O)c3ccnc(C#Cc4cncc5ccccc45)c3)cc2C(F)(F)F)CC1 CHEMBL4092294 IC50 2.2 nM
Cc1ccc2oc(-c3c4c(N)n[nH]c(=O)c4nn3C3CCN(C(=O)C#CCO)CC3)c(C)c2c1 CHEMBL5282211 IC50 2.2 nM
COc1cc(OC)c(Cl)c(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3986068 pIC50 2.239 nM
COc1cc(Nc2ncc3c(n2)N(C2CCN(C(=O)/C=C/CN(C)C)CC2)C(=O)N(c2c(Cl)c(OC)cc(OC)c2Cl)C3)ccc1F CHEMBL4099403 IC50 2.28 nM
COc1cc(OC)cc(N(CCCCN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3969373 pIC50 2.291 nM
COc1cc(OC)cc(N(C[C@H](O)CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3939764 pIC50 2.291 nM
COc1cc(OC)cc(N(CC(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3900574 pIC50 2.291 nM
COc1cc(OC)cc(N(CCNCC2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3935457 pIC50 2.291 nM
CNC(=O)c1cc(F)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3901612 pIC50 2.291 nM
C=CC(=O)N1CCN(CCn2c(=O)c(-c3c(Cl)c(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)CC1 CHEMBL4062003 IC50 2.3 nM
C=CC(=O)N1CCC(n2nc3c(=O)[nH]nc(N)c3c2-c2oc3cc(C)ccc3c2C)CC1 CHEMBL5276626 IC50 2.3 nM
CNc1ncc2c(n1)N([C@H]1CCN(C(=O)/C=C/CN(C)C)C1)C(=O)N(c1c(Cl)c(OC)cc(OC)c1Cl)C2 CHEMBL4061908 IC50 2.33 nM
COc1cc(OC)cc(N(CCNC(=O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3912831 pIC50 2.344 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCNC(C)C)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3909551 pIC50 2.344 nM
CCN(CCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1)C(C)C CHEMBL3944320 pIC50 2.344 nM
COc1cc(OC)cc(N(CCCC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3955706 pIC50 2.399 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3893008 pIC50 2.399 nM
CNCC(O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3935264 pIC50 2.399 nM
CNCC(O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3932577 pIC50 2.399 nM
COc1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3908877 pIC50 2.399 nM
COc1cc(OC)cc(N(CCN2C(C)CCCC2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3920007 pIC50 2.399 nM
COc1cc(OC)cc(N(CCCN2CCCC(C(N)=O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3910444 pIC50 2.399 nM
COc1cc(OC)cc(N(Cc2cnccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3890378 pIC50 2.399 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C([2H])([2H])C([2H])([2H])O)c1 CHEMBL3946938 pIC50 2.399 nM
COc1cc(OC)cc(N(CC#Cc2cc(CO)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3980417 pIC50 2.399 nM
CC(Oc1ccc2[nH]nc(-c3cc4ccccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3828173 IC50 2.4 nM
COc1cc(C)cc2cc(-c3c(CN[C@@H]4CCNC4=O)c(CN4CCN(C(C)=O)CC4)n4ncnc(N)c34)sc12 CHEMBL4108692 IC50 2.4 nM
Cc1ccc2oc(-c3c4c(N)n[nH]c(=O)c4nn3-c3ccc(NC(=O)/C=C/CN(C)C)cc3)c(C)c2c1 CHEMBL4463714 IC50 2.4 nM
CCN1CCC(n2cc(-c3cnc4ccc(N(CCNC(C)C)c5cc(OC)cc(OC)c5)cn4c3=O)cn2)CC1 CHEMBL4854151 IC50 2.4 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 2.42 nM
COc1cc(OC)cc(N(CC(O)CN2CCCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3969475 pIC50 2.455 nM
CCn1cc(-c2cnc3ccc(N(CCNC)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3893344 pIC50 2.455 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(N6CCOCC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681284 IC50 2.5 nM
COc1cc(C)cc2cc(-c3c(CO)c(CN4CCNC(=O)C4)n4ncnc(N)c34)sc12 CHEMBL3914307 IC50 2.5 nM
C=CC(=O)N1CCCC1Cn1cc(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnc21 CHEMBL4472968 IC50 2.5 nM
COc1cc(OC)cc(N(CCNC2CCC(O)CC2)c2ccc3ncc(-c4cnn(C)c4)c(=O)n3c2)c1 CHEMBL4851029 IC50 2.5 nM
Cc1cc(CNc2ncc(Br)c(Nc3cc(CCc4ccccc4)[nH]n3)n2)on1 CHEMBL2088095 pIC50 2.512 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3949470 pIC50 2.512 nM
COc1cc(OC)cc(N(CCN2CCC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3939200 pIC50 2.512 nM
COc1cc(OC)cc(N(C[C@H](O)CNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3941695 pIC50 2.512 nM
COc1cc(O)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3893642 pIC50 2.512 nM
COc1cc(O)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3962492 pIC50 2.512 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cn(C)nc4C(F)(F)F)nc3c2)c1 CHEMBL3948234 pIC50 2.512 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3958153 pIC50 2.57 nM
COC[C@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C(C)C)c3)nc2c1 CHEMBL3926556 pIC50 2.57 nM
C=CC(=O)N1CCCC(n2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnc32)C1 CHEMBL4554916 IC50 2.6 nM
C=CC(=O)N1CCC(n2cc(-c3cc4cc(OC)cc(OC)c4s3)c3c(N)ncnc32)C1 CHEMBL4567572 IC50 2.6 nM
[2H]C([2H])([2H])Oc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3925081 pIC50 2.63 nM
COc1cc(OC)cc(N(CCNC(=O)C2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3963323 pIC50 2.63 nM
COc1cc(OC)cc(N(CCCN2CCC(C(F)(F)F)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3936087 pIC50 2.63 nM
COc1cc(OC)cc(N(CCCNCC(C)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3966200 pIC50 2.63 nM
COc1cc(OC)cc(N(CC#Cc2nccc(OC)n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3953833 pIC50 2.63 nM
COc1cccnc1C#CCN(c1ccc2ncc(-c3cnn(C)c3)nc2c1)c1c(Cl)c(OC)cc(OC)c1Cl CHEMBL3969667 pIC50 2.63 nM
COc1cc(OC)cc(N(CC2CCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3926406 pIC50 2.692 nM
COc1cc(OC)cc(N(CCCN2C[C@@H](C)O[C@@H](C)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3914955 pIC50 2.692 nM
COc1cc(OC)cc(N(CCCN2CCOCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3928261 pIC50 2.692 nM
COc1cc(OC)cc(N(CCCN2[C@H](C)CC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3927451 pIC50 2.692 nM
COc1cc(OC)cc(N(Cc2cccnc2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3928239 pIC50 2.692 nM
COc1cc(OC)cc(N(CC#Cc2ccncc2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3897523 pIC50 2.692 nM
COc1cc(OC)cc(N(CCN2C[C@@H]3C[C@H]2CN3)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3940672 pIC50 2.692 nM
CC(Oc1ccc2[nH]nc(-c3nc4cc(N5CCCCC5)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3828561 IC50 2.7 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(OCCN6CCOCC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3676315 IC50 2.7 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(CN6CCOC[C@@H]6C)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3676328 IC50 2.7 nM
COc1cc(C)cc2cc(-c3c(CN4CCNC(=O)C4)c(C#N)n4ncnc(N)c34)sc12 CHEMBL3897839 IC50 2.7 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCO)c4)c(=O)n3c2)c1 CHEMBL4862468 IC50 2.7 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3901627 pIC50 2.754 nM
COc1ccc(Cl)c(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3983387 pIC50 2.754 nM
COc1cc(OC)cc(N(CC(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3911635 pIC50 2.754 nM
COc1cc(OC)cc(N(CCF)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3891525 pIC50 2.754 nM
COc1cc(C#Cc2cn(C3CN(C(=O)/C=C/CN(C)C)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701267 IC50 2.8 nM
COc1ccc2[nH]c(-c3n[nH]c4ccc(OC(C)c5c(Cl)cncc5Cl)cc34)nc2c1 CHEMBL3828142 IC50 2.8 nM
COc1cc(C)cc2cc(-c3c(COCCN)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3958993 IC50 2.8 nM
COc1cc(C)cc2cc(-c3c(CN4CCC(O)CC4)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3906882 IC50 2.8 nM
COc1cc(C)cc2cc(-c3c(CN4CCNC(=O)C4)c(C)n4ncnc(N)c34)sc12 CHEMBL3943773 IC50 2.8 nM
C=CC(=O)Nc1cccc(CCn2c(=O)c(-c3cc(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)c1 CHEMBL4095783 IC50 2.8 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4coc(N5CCN(C)CC5)n4)c3)ccc12 CHEMBL4277282 IC50 2.8 nM
CCOC(=O)C1CCN(CCN(c2cc(OC)cc(OC)c2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)CC1 CHEMBL3904745 pIC50 2.818 nM
[2H]C([2H])([2H])n1cc(-c2ccc3ncc(N(CCO)c4cc(OC)cc(OC)c4)nc3c2)cn1 CHEMBL3959849 pIC50 2.818 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)[C@H]2CC[C@H](NC(C)C)CC2)c1 CHEMBL3918800 pIC50 2.818 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC(=O)NCCO)c4)nc3c2)c1 CHEMBL3985750 pIC50 2.884 nM
COc1ccc(Cl)c(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3969824 pIC50 2.884 nM
COc1cc(OC)c(C)c(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3947361 pIC50 2.884 nM
COc1cc(OC)cc(N(CCCN2CCC(N3C[C@@H](C)O[C@@H](C)C3)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3961400 pIC50 2.884 nM
COc1cc(OC)cc(N(CCN2CC=CCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3979670 pIC50 2.884 nM
Cc1nc2ccc(-n3ncc(C(=O)c4cc5cc(CN6CCOCC6)ccc5[nH]4)c3N)cc2[nH]1 CHEMBL3891894 IC50 2.9 nM
CCc1nc2cc(-n3ncc(C(=O)c4cc5ccccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681287 IC50 2.9 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(CN6CCC(F)(F)CC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681314 IC50 2.9 nM
Cn1cc(-c2ccc3c(c2)ncn3-c2cc(NC(=O)Cn3cncn3)cc(-c3ccc(F)cc3F)c2)cn1 CHEMBL3963522 IC50 2.9 nM
CCN1CCN(c2ccc(C(=O)Nc3n[nH]c4cc(-c5cccc(OC)c5F)ccc34)cc2)CC1 CHEMBL4076610 IC50 2.9 nM
C=CC(=O)N1CC(n2cc(-c3cc4ccc(OC)cc4s3)c3c(N)ncnc32)C1 CHEMBL4437731 IC50 2.9 nM
CCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3931533 pIC50 2.951 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCCN5CCOCC5)c4)nc3c2)c1 CHEMBL3927327 pIC50 2.951 nM
COc1cc(OC)cc(N(CCN2CC3(COC3)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3934487 pIC50 2.951 nM
COc1cc(OC)cc(N(CCN2CCC(C(C)(C)O)CC2)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3969112 pIC50 2.951 nM
COc1cc(OC)cc(N(CCCN2[C@@H](C)CC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3968139 pIC50 2.951 nM
COc1cc(O)cc(N(CCCO)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3897155 pIC50 2.951 nM
CC(C)(C)NC(=O)Nc1cccc2[nH]nc(-c3nc4cc(N5CCC(N6CCCCC6)CC5)ccc4[nH]3)c12 CHEMBL379740 IC50 3.0 nM
CN(C)CC(=O)N(C)c1ccc2[nH]c(-c3c(N)c4ccccc4[nH]c3=O)nc2c1 CHEMBL495962 IC50 3.0 nM
Cc1cccc2[nH]c(=O)c(-c3nc4cc(N5CCN(C)CC5)ccc4[nH]3)c(N)c12 CHEMBL495763 IC50 3.0 nM
CN1CCN(c2ccc3[nH]c(-c4c(N)c5ccc(F)cc5[nH]c4=O)nc3c2)CC1 CHEMBL498013 IC50 3.0 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(OC6CCOCC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3676316 IC50 3.0 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5cc(C(=O)O)ccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681295 IC50 3.0 nM
CNCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCNCC1 CHEMBL3948716 IC50 3.0 nM
Cc1nc2ccc(-n3ncc(C(=O)c4cc5ccccc5[nH]4)c3N)cc2[nH]1 CHEMBL3907479 Kd apparent 3.0 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cncc(N2CCOCC2)c1 CHEMBL4094115 IC50 3.0 nM
COc1cc(OC)cc(N(CCN2CC[C@H](C#N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3960327 pIC50 3.02 nM
CNC(=O)c1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3927733 pIC50 3.02 nM
COc1cc(OC)cc(N(Cc2ccc(Cl)nc2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907642 pIC50 3.02 nM
CNc1ncc2c(n1)N([C@H]1CCCN(C(=O)/C=C/CN(C)C)C1)C(=O)N(c1c(Cl)c(OC)cc(OC)c1Cl)C2 CHEMBL4100110 IC50 3.08 nM
CCOC(=O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3921313 pIC50 3.09 nM
COc1cc(OC)cc(N(Cc2ccco2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3975954 pIC50 3.09 nM
COc1cc(OC)cc(N(Cc2cccs2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3911516 pIC50 3.09 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C5CCN(C(=O)OC(C)(C)C)CC5)c4)nc3c2)c1 CHEMBL3977010 pIC50 3.09 nM
COc1cc(C#Cc2cn(C3CN(C(=O)/C=C/CN4CC[C@H](O)C4)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701274 IC50 3.1 nM
COc1cc(C)cc2cc(-c3c(CN)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3924079 IC50 3.1 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)csc12 CHEMBL2005631 pKi 3.162 nM
COc1cc(OC)cc(N(CC(O)CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3943387 pIC50 3.162 nM
CNC(=O)c1cc(F)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3918704 pIC50 3.162 nM
COc1cc(OC)cc(N(CC#Cc2cc(OC)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3927140 pIC50 3.162 nM
C=CC(=O)N1CC(n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701241 IC50 3.2 nM
COc1cc(C)cc2cc(-c3c(CNC4CC4)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3930377 IC50 3.2 nM
COc1cc(C)cc2cc(-c3c(CNCC(C)(C)O)c(CN4CCN(C(C)=O)CC4)n4ncnc(N)c34)sc12 CHEMBL3949626 IC50 3.2 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2c(-c3cnn(C4CCCCO4)c3)n[nH]c2c1 CHEMBL4580357 IC50 3.2 nM
C=CC(=O)N1CCN(CCCCCn2nc(-c3cc(OC)cc(OC)c3)c3c(N)ncnc32)CC1 CHEMBL5084546 IC50 3.21 nM
COc1cc(OC)cc(N(CC(O)CN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3936828 pIC50 3.236 nM
COc1cc(OC)cc(N(CCN(CCCN)C(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3902434 pIC50 3.236 nM
COc1cc(C)cc2cc(-c3c(CO)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3929808 IC50 3.3 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(N5CCN(C)CC5)cc4)n[nH]c3c2)c1Cl CHEMBL4562845 IC50 3.3 nM
COc1cc(OC)cc(N(CCP(=O)(O)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3950169 pIC50 3.311 nM
COc1cc(OC)cc(N(CCNC(=O)C2CCCN(C)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3979885 pIC50 3.388 nM
COc1cc(OC)cc(N(CCN2CCC[C@H]2C(=O)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3959201 pIC50 3.388 nM
COc1cc(OC)cc(N(Cc2cn[nH]n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3904561 pIC50 3.388 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)[C@@H](C)CN)c1 CHEMBL3922607 pIC50 3.388 nM
COc1cc(OC)cc(N(CC(C)N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3979172 pIC50 3.388 nM
Cc1cc(C(=O)Nc2cccc(C(=O)c3ccc4c(/C=C/c5ccccn5)n[nH]c4c3)c2)n(C(C)C)n1 CHEMBL3911423 Ki 3.4 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(C3CCN(C[C@H](C)O)CC3)cc2)c1 CHEMBL3691333 IC50 3.4 nM
COc1cc(C)cc2cc(-c3c(CN4CCCC4)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3907380 IC50 3.4 nM
CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(CCN5CCOCC5)nn4)ccc32)c1 CHEMBL3942896 IC50 3.4 nM
CC(=O)Nc1cc(-c2ccc(F)cc2)cc(-n2cnc3cc(-c4cnn(CCC(C)(C)O)c4)ccc32)c1 CHEMBL3970388 IC50 3.4 nM
COc1cc(OC)cc(N(CC2CO2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3974664 pIC50 3.467 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CCS(C)(=O)=O)c3)nc2c1 CHEMBL3984548 pIC50 3.467 nM
COc1cc(OC)cc(N(CCN2CCC(C(C)(C)O)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3931154 pIC50 3.467 nM
CC(=O)Nc1cc(C(=O)c2ccc3c(/C=C/c4ccccn4)n[nH]c3c2)ccc1C CHEMBL3963901 Ki 3.5 nM
CNc1ncc2c(n1)N([C@@H]1CCCN(C(=O)/C=C/CN(C)C)C1)C(=O)N(c1c(Cl)c(OC)cc(OC)c1Cl)C2 CHEMBL4064676 IC50 3.54 nM
CNC(=O)c1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(CCOC)c4)nc3c2)c1 CHEMBL3908529 pIC50 3.548 nM
COc1cc(OC)cc(N(CCCNCC(F)(F)F)c2ccc3ncc(-c4cnn(CCCN)c4)nc3c2)c1 CHEMBL3892155 pIC50 3.548 nM
CCN1CCN(c2ccc3[nH]c(-c4n[nH]c5ccc(OC(C)c6c(Cl)cncc6Cl)cc45)nc3c2)CC1 CHEMBL3827706 IC50 3.6 nM
C=CC(=O)Nc1cccc(CN2C(=O)N(c3c(Cl)c(OC)cc(OC)c3Cl)Cc3cnc(NCCCCN(CC)CC)nc32)c1 CHEMBL2216830 IC50 3.6 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cncc(NC(C)C)c1 CHEMBL4064874 IC50 3.6 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(OCCN5CC(F)C5)cc4)c3)ccc12 CHEMBL4282937 IC50 3.6 nM
COc1cc(OC)cc(N(CCN2CC[C@H](C#N)C2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3898568 pIC50 3.631 nM
COc1cc(OC)cc(N(CCN2CCN(CCO)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3983529 pIC50 3.631 nM
COc1cc(OC)cc(N(CCN2CCN(C)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3905048 pIC50 3.631 nM
CCOc1ccnc(C#CCN(c2cc(OC)cc(OC)c2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)n1 CHEMBL3894754 pIC50 3.631 nM
CCN1CCN(c2ccc(Nc3cc(-c4cccnc4Nc4c(Cl)c(OC)cc(OC)c4Cl)ncn3)cc2)CC1 CHEMBL5194218 IC50 3.68 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(C3CCN(C)CC3)cc2)c1 CHEMBL3691342 IC50 3.7 nM
COc1cc(C)cc2cc(-c3c(C)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3948076 IC50 3.7 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1C(=O)N[C@H]1CCNC1=O CHEMBL3944496 IC50 3.7 nM
COc1ccc(F)c(-c2ccc3c(NC(=O)c4ccc(N5CCCN(C)CC5)cc4)n[nH]c3c2)c1F CHEMBL4086560 IC50 3.7 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(C4=CCN(C(=O)OC(C)(C)C)CC4)c(=O)n3c2)c1 CHEMBL4849708 IC50 3.7 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC(=O)N(C)C)c4)nc3c2)c1 CHEMBL3925254 pIC50 3.715 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cn[nH]c3)nc2c1 CHEMBL3920908 pIC50 3.715 nM
COc1cc(OC)cc(N(CCN2CCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3890607 pIC50 3.715 nM
COc1cc(OC)cc(N(C[C@@H]2C[C@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3913970 pIC50 3.715 nM
COCC(O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3942594 pIC50 3.715 nM
COc1cc(OC)cc(N(CCN2[C@@H](C)CC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3932756 pIC50 3.715 nM
COc1cc(CCc2cc(-c3nc4ccc(CN5CCOCC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5191338 IC50 3.76 nM
COc1cc(CCc2cc(-c3nc4ccc(N5CCOCC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5207255 IC50 3.79 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5cc(C(=O)N6CCOCC6)ccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681285 IC50 3.8 nM
COc1cc(C)cc2cc(-c3c(CN4CCNC(=O)C4)c(CN4CCN(C(C)=O)CC4)n4ncnc(N)c34)sc12 CHEMBL3954561 IC50 3.8 nM
CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnco4)ccc32)c1 CHEMBL3912202 IC50 3.8 nM
C=CC(=O)N1CC(n2cc(-c3cc4ccccc4s3)c3c(N)ncnc32)C1 CHEMBL4521898 IC50 3.8 nM
COc1cc(OC)cc(N(CC2OCCO2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3901644 pIC50 3.802 nM
COc1cc(OCCO)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3909318 pIC50 3.802 nM
COc1cc(OC)cc(N(C[C@H](C)N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3895378 pIC50 3.802 nM
COc1cc(OC)cc(N(CCCc2ccncc2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3920637 pIC50 3.802 nM
COCCNC(=O)Cn1cc(-c2cnc3ccc(N(CC4CC4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3983115 pIC50 3.89 nM
COc1cc(OCCO)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3974693 pIC50 3.89 nM
COc1cc(OC)cc(N(CCN2CCCC(N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3957533 pIC50 3.89 nM
COc1cc(OC)cc(N(CCN(Cc2ccc(N)cc2)C(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3950496 pIC50 3.89 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(C3CCN(CC(C)(C)O)CC3)cc2)c1 CHEMBL3691341 IC50 3.9 nM
COc1cc(C)cc2cc(-c3c(CNCC(C)O)c(CN4CCOCC4)n4ncnc(N)c34)sc12 CHEMBL3944881 IC50 3.9 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CO CHEMBL3953385 IC50 3.9 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1C(=O)NCCO CHEMBL3949665 IC50 3.9 nM
COCc1c(CN2CCNC(=O)C2)c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn12 CHEMBL3897224 IC50 3.9 nM
C=CC(=O)Nc1ccc(CCn2c(=O)c(-c3cc(OC)cc(OC)c3Cl)cc3cnc(NCC(O)CO)nc32)cc1 CHEMBL4100201 IC50 3.9 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(N(C)CCN(C)C)cc4)n[nH]c3n2)c1Cl CHEMBL4559114 IC50 3.9 nM
COc1cc(CCc2cc(-c3nc4ccc(CN5CCN(C)CC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5174735 IC50 3.9 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(Cc5ccc(CC(=O)NO)cc5)c4)nc3c2)c1 CHEMBL5170264 IC50 3.9 nM
C#CC(=O)N1CCCC(n2nc3c(=O)[nH]nc(N)c3c2-c2oc3ccc(C)cc3c2C)C1 CHEMBL5286832 IC50 3.9 nM
COc1cc(OC)cc(N(CC#CC2(O)CNC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3922100 pIC50 3.981 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C([2H])([2H])C([2H])([2H])C([2H])([2H])O)c1 CHEMBL3906284 pIC50 3.981 nM
COC[C@@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CCCN)c3)nc2c1 CHEMBL3942506 pIC50 3.981 nM
COc1cc(OC)cc(-c2cc3cnc(NCCCO)cc3nc2NC(=O)NC(C)(C)C)c1 CHEMBL278472 IC50 4.0 nM
CN1CCN(c2ccc3[nH]c(-c4c(O)nc5cnccc5c4N)nc3c2)CC1 CHEMBL205893 IC50 4.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2cccc(F)c2)c2nc(C)c[nH]2)C(=O)N3)CC1 CHEMBL2087167 IC50 4.0 nM
COc1cc(C)cc2cc(-c3c(CN4CCNC(=O)C4)c(C(C)(C)O)n4ncnc(N)c34)sc12 CHEMBL3920417 IC50 4.0 nM
COc1cc(OC)cc(N(CCc2nnn[nH]2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3905212 pIC50 4.074 nM
COc1cc(OC)cc(N(Cc2ccc(Cl)s2)c2ccc3ncc(-c4cnn(CCN5CCNCC5)c4)nc3c2)c1 CHEMBL3904441 pIC50 4.074 nM
COc1cc(F)cc(N(CCCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3951360 pIC50 4.074 nM
COc1cc(O)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907327 pIC50 4.074 nM
COc1cc(CCc2cc(-c3nc4ccc(N5C[C@@H](C)O[C@@H](C)C5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5173892 IC50 4.09 nM
c1ccc(COc2ccc3[nH]nc(-c4nc5cc(N6CCCCC6)ccc5[nH]4)c3c2)nc1 CHEMBL3828317 IC50 4.1 nM
COc1cc(C)cc2cc(-c3c(CO)c(C)n4ncnc(N)c34)sc12 CHEMBL3919371 IC50 4.1 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(OCCN5CCCC5)cc4)c3)ccc12 CHEMBL4278930 IC50 4.1 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(N5CCN(C)CC5)s4)n[nH]c3n2)c1Cl CHEMBL4561437 IC50 4.1 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2[nH]ncc2c1 CHEMBL2316582 IC50 4.14 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C5CN(CCO)C5)c4)nc3c2)c1 CHEMBL3906122 pIC50 4.169 nM
COc1cc(OC)cc(N(CCNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3950156 pIC50 4.169 nM
COc1cc(OC)cc(N(CCNCCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3895443 pIC50 4.169 nM
CNC(=O)c1cc(OC)cc(N(CC(O)CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3910555 pIC50 4.169 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5c(NC(CO)CO)cccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681282 IC50 4.2 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(C3CCN(C[C@@H](C)O)CC3)cc2)c1 CHEMBL3691332 IC50 4.2 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(C3CCN(CC)CC3)cc2)c1 CHEMBL3691334 IC50 4.2 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN[C@@H]1CCNC1=O CHEMBL4106638 IC50 4.2 nM
COc1cc(C)cc2cc(-c3c(COCCO)c(CN4CCNC(=O)C4)n4ncnc(N)c34)sc12 CHEMBL3923490 IC50 4.2 nM
C=CC(=O)Nc1cc(-c2cc3c(cn2)cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c(=O)n3CC)ccc1N1CCN(CC)CC1 CHEMBL5175788 IC50 4.2 nM
CCOCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3906155 pIC50 4.266 nM
COc1cc(OCCF)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3946674 pIC50 4.266 nM
COc1cc(OC)cc(N(CCNC2CCN(S(N)(=O)=O)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3917295 pIC50 4.266 nM
COc1ccc(-c2cc(NC(C)=O)cc(-n3cnc4cc(-c5cnn(C)c5)ccc43)c2)c(F)c1 CHEMBL3943168 IC50 4.3 nM
COc1cc(CCc2cc(-c3nc4ccc(CN5CCC(N6CCNCC6)CC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5201819 IC50 4.33 nM
COc1cc(OC)cc(N(C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3947740 pIC50 4.365 nM
COc1cc(OC)cc(N(C[C@@H](O)CNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3891966 pIC50 4.365 nM
COc1cc(OC)cc(N(C[C@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3916037 pIC50 4.365 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(C3CCNCC3)cc2)c1 CHEMBL3686886 IC50 4.4 nM
COc1cc(C)cc2cc(-c3c(CN[C@H]4CCNC4=O)c(CN4CCOCC4)n4ncnc(N)c34)sc12 CHEMBL3905636 IC50 4.4 nM
COc1cc(C)cc2cc(-c3c(CO)c(C(C)(C)O)n4ncnc(N)c34)sc12 CHEMBL3892430 IC50 4.4 nM
C=CC(=O)N1CC(n2cc(-c3cc4c(OC)ccc(OC)c4s3)c3c(N)ncnc32)C1 CHEMBL4543663 IC50 4.4 nM
COc1cc(OC)c(F)c(N2Cc3cnc4c(c3N(CCO)C2=O)CC(=O)N4)c1F CHEMBL4874869 IC50 4.4 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3955288 pIC50 4.467 nM
COc1cc(OC)cc(N(CC(C)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3904329 pIC50 4.467 nM
COCCNC(=O)C(C)(C)n1cc(-c2cnc3ccc(N(CC4CC4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3962805 pIC50 4.467 nM
COc1cc(OC)cc(N(CCCN2CCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3973263 pIC50 4.467 nM
C=CC(=O)Nc1ccccc1C(=O)Nc1cc(CCc2cc(OC)cc(OC)c2)[nH]n1 CHEMBL4284069 IC50 4.5 nM
C=CC(=O)N1CCC(c2cc3c(Oc4ccc(NC(=O)NC5CC5)c(Cl)c4)ccnc3cc2OCC)CC1 CHEMBL5436527 IC50 4.5 nM
COc1cc(OC)cc(N(CCN2CCC(N(C)C)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3962554 pIC50 4.571 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(F)c(F)c4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4087420 IC50 4.59 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCNC(=O)C1 CHEMBL3979989 IC50 4.6 nM
COC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(N5C[C@@H](C)N[C@@H](C)C5)cc4)c3)ccc12 CHEMBL4281259 IC50 4.6 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 IC50 4.63 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CC4CC4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3907600 pIC50 4.677 nM
COc1cc(OC)cc(N(C/C(C)=N/O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3955817 pIC50 4.677 nM
COc1cc(OC)cc(N(CCNC2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3918495 pIC50 4.677 nM
CNC(=O)c1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3965640 pIC50 4.677 nM
COc1cc(OC)cc(N(CCCN2CCCC2=O)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3904294 pIC50 4.677 nM
COc1cc(OC)cc(N(C[C@@H](C)N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3898346 pIC50 4.677 nM
C=CC(=O)N(C)c1ccc(CCn2c(=O)c(-c3cc(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)cc1 CHEMBL4072676 IC50 4.7 nM
C=CC(=O)Nc1ccc(CCn2c(=O)c(-c3cc(OC)cc(OC)c3Cl)cc3cnc(NC4CCN(C)CC4)nc32)cc1 CHEMBL4102058 IC50 4.7 nM
COc1cc(CCc2cc(-c3nc4cc(F)c(N5CCOCC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5171314 IC50 4.74 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCCN5CCN(CCCO)CC5)c4)nc3c2)c1 CHEMBL3908829 pIC50 4.786 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3892776 pIC50 4.786 nM
COc1cc(OC)cc(N(CC(O)CN2CCOCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3966560 pIC50 4.786 nM
COc1cc(OC)cc(N(CCN2CCCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3982107 pIC50 4.786 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C(C)CNCC(F)(F)F)c1 CHEMBL3890852 pIC50 4.786 nM
COC[C@@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C(C)C)c3)nc2c1 CHEMBL3965482 pIC50 4.786 nM
COc1cc(OC)cc(N(CC2CCN(C)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3893070 pIC50 4.898 nM
COc1cc(OC)cc(N(CCCN2CCOC2=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3903198 pIC50 4.898 nM
COc1cc(OC)cc(N(CCNCC2CCCO2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3896623 pIC50 4.898 nM
CC(=O)Nc1cccc(Oc2ccc3c(/C=C/c4ccccc4)n[nH]c3c2)c1 CHEMBL3944307 Ki 4.9 nM
COc1cc(OC)cc(-c2cc3cnc(NCCCN4CCN(C)CC4)cc3nc2NC(=O)NC(C)(C)C)c1 CHEMBL189995 IC50 5.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccccc2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 CHEMBL2086753 IC50 5.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2cccc(F)c2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 CHEMBL2086756 IC50 5.0 nM
Cc1nc2cc(-n3ncc(C(=O)C4=CC5C=CC=CC5N4)c3N)ccc2[nH]1 CHEMBL3676312 IC50 5.0 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(C[C@H](C)O)CC5)cc4)c3)c(OCCOC)cc21 CHEMBL3691321 IC50 5.0 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(C3CN(C(C)C)C3)cc2)c1 CHEMBL3691328 IC50 5.0 nM
COc1cc(C)cc2cc(-c3c(CNC(C)=O)c(CN4CCNC(=O)C4)n4ncnc(N)c34)sc12 CHEMBL3976573 IC50 5.0 nM
COc1cc(C)cc2cc(-c3c(CN4CCNC(=O)C4)c(CO)n4ncnc(N)c34)sc12 CHEMBL3968346 IC50 5.0 nM
c1ccc(CNc2nc(Nc3cc(C4CC4)[nH]n3)c3sccc3n2)cc1 CHEMBL1997924 pKi 5.012 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL49120 pKi 5.012 nM
COc1cc(CCc2cc(Nc3ccnc(NCc4ccccn4)n3)n[nH]2)cc(OC)c1 CHEMBL2088259 pIC50 5.012 nM
CNC(=O)OCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3973531 pIC50 5.012 nM
CC(Oc1ccc2[nH]nc(-c3nc4ccccc4o3)c2c1)c1c(Cl)cncc1Cl CHEMBL3827803 IC50 5.1 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5c(NCCN6CCOCC6)cccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681279 IC50 5.1 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(CN3CCC[C@H]3CO)s2)c1 CHEMBL3691336 IC50 5.1 nM
COc1cc(C)cc2cc(-c3c(CN4CCC(O)C4)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3980564 IC50 5.1 nM
COc1cc(OC)cc(N(CC2CCCO2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3940334 pIC50 5.129 nM
COc1cc(OC)cc(N(C[C@@H](O)CN2CC[C@H](C#N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3967065 pIC50 5.129 nM
COc1cc(OC)cc(N(CCC(=O)N(C)OC)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3956493 pIC50 5.129 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(C3CCN(CCO)CC3)cc2)c1 CHEMBL3686887 IC50 5.2 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(C[C@@H](C)O)CC5)cc4)c3)c(OCCCOC)cc21 CHEMBL3691353 IC50 5.2 nM
COc1cc(C)cc2cc(-c3c(COCC(=O)O)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3962751 IC50 5.2 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(C#Cc4cncc5ccccc45)c3)cc2C(F)(F)F)CC1 CHEMBL4104537 IC50 5.2 nM
COc1cc(OC)cc(N(CCS(C)(=O)=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3942716 pIC50 5.248 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(CN6CCC(O)CC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3676313 IC50 5.3 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(C(C)C)CC5)cc4)c3)c(OCCOC)cc21 CHEMBL3686885 IC50 5.3 nM
C=CC(=O)Nc1cccc(Cn2c(=O)c(-c3cc(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)c1 CHEMBL4085605 IC50 5.3 nM
COCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3933449 pIC50 5.37 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCN5CCCC5)c4)nc3c2)c1 CHEMBL3962814 pIC50 5.37 nM
CCN1CCC(c2ccc(C(=O)Nc3cc(Oc4cc5ccn(C(=O)NC)c5cc4OCCOC)ccn3)cc2)CC1 CHEMBL3691322 IC50 5.4 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(CN3CC[C@@H](O)C3)s2)c1 CHEMBL3691262 IC50 5.4 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(C3CCN(C(C)C)CC3)cc2)c1 CHEMBL3691331 IC50 5.4 nM
COc1cc(OC)cc(N(CC2(CNC(C)C)COC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3956579 pIC50 5.495 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4CCCO)nc3c2)c1 CHEMBL3978349 pIC50 5.495 nM
C#CCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CC4CCOCC4)c3)nc2c1 CHEMBL3939018 pIC50 5.495 nM
COc1cc2[nH]c(C(=O)c3cnn(-c4ccc5[nH]c(C)nc5c4)c3N)cc2cc1Cl CHEMBL3681303 IC50 5.5 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(C[C@@H](C)O)CC5)cc4)c3)c(OC)cc21 CHEMBL3691279 IC50 5.5 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN[C@H]1CCNC1=O CHEMBL3938754 IC50 5.5 nM
CCN1CCN(C(=O)c2ccc3nc(-c4cc(CCc5cc(OC)cc(OC)c5)[nH]n4)[nH]c3c2)CC1 CHEMBL5191301 IC50 5.55 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCNCC5)cc4)c3)c(OCCOC)cc21 CHEMBL3686882 IC50 5.6 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(CN3CCC(O)CC3)s2)c1 CHEMBL3691337 IC50 5.6 nM
COc1cc(C)cc2cc(-c3c(CNC(C)=O)c(CN4CCN(C=O)CC4)n4ncnc(N)c34)sc12 CHEMBL3968059 IC50 5.6 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CNC(=O)C1 CHEMBL3985125 IC50 5.6 nM
COc1ccc(F)c(-c2ccc3c(NC(=O)c4ccc(N5CCN(C)CC5)cc4)n[nH]c3c2)c1F CHEMBL4096740 IC50 5.6 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC(=O)N5CCC(O)C5)c4)nc3c2)c1 CHEMBL3929803 pIC50 5.623 nM
CNC(=O)c1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3912310 pIC50 5.623 nM
CNCCN(c1cc(F)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3891464 pIC50 5.623 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CC4CCOCC4)c3)nc2c1 CHEMBL3932363 pIC50 5.623 nM
COc1cc(OC)cc(N(Cc2ncccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3901265 pIC50 5.623 nM
CCC(Oc1ccc2[nH]nc(-c3nc4cc(N5CCCCC5)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3827608 IC50 5.7 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(C)CC5)cc4)c3)c(OCCOC)cc21 CHEMBL3686883 IC50 5.7 nM
CCN1CC(c2ccc(C(=O)Nc3cc(Oc4cc5ccn(C(=O)NC)c5cc4OCCOC)ccn3)cc2)C1 CHEMBL3691319 IC50 5.7 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(C3CN(CC(C)(C)O)C3)cc2)c1 CHEMBL3691325 IC50 5.7 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cncc(N2CCN(C)CC2)c1 CHEMBL4083853 IC50 5.7 nM
COc1cc(CCc2cc(-c3nc4ccc(CN5CCC(N6CCN(C)CC6)CC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5186357 IC50 5.72 nM
CNC(=O)c1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3929648 pIC50 5.754 nM
COc1cc(OC)cc(N(CCCN2CCC(F)(F)C2)c2ccc3ncc(-c4cnn(CC5CCOCC5)c4)nc3c2)c1 CHEMBL3924422 pIC50 5.754 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(CCO)CC5)cc4)c3)c(OCCOC)cc21 CHEMBL3686884 IC50 5.8 nM
COc1cc(OC)cc(N(CCN2CCC(N)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3893718 pIC50 5.888 nM
COc1cc(OC)cc(N(CC#CC2(O)CCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3984035 pIC50 5.888 nM
COc1cc(OC)cc(N(C[C@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3969414 pIC50 5.888 nM
COc1cc(CCc2cc(-c3nc4ccc(N5C[C@@H](C)N[C@@H](C)C5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5182544 IC50 5.89 nM
COc1cc(CCc2cc(-c3nc4ccc(CN5C[C@@H](C)N[C@@H](C)C5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5180534 IC50 5.89 nM
C=CC(=O)N1CCN(CCCCCCCn2nc(-c3cc(OC)cc(OC)c3)c3c(N)ncnc32)CC1 CHEMBL5091141 IC50 5.9 nM
COc1cc(OC)cc(-c2cc3cnc(NCCCCN4CCN(C)CC4)cc3nc2NC(=O)NC(C)(C)C)c1 CHEMBL190161 IC50 6.0 nM
CCN(CC)CCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(-c3cc(OC)cc(OC)c3)cc2cn1 CHEMBL191023 IC50 6.0 nM
CCN(CC)CCCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(-c3cc(OC)cc(OC)c3)cc2cn1 CHEMBL192856 IC50 6.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccc(Cl)cc2)c2ncc[nH]2)C(=O)N3)CC1 CHEMBL2086760 IC50 6.0 nM
COc1cc(C)cc2cc(-c3c(COCC(N)=O)c(CN4CCN(C(C)=O)CC4)n4ncnc(N)c34)sc12 CHEMBL3954008 IC50 6.0 nM
COc1ccc2nc(N3CCC(C(CC#N)n4cc(-c5ncnc6[nH]ccc56)cn4)CC3)sc2c1 CHEMBL4862283 IC50 6.0 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C(C)(C)C(=O)NCCO)c4)nc3c2)c1 CHEMBL3976219 pIC50 6.026 nM
COc1cc(OC)cc(N(CCNCCC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3951847 pIC50 6.026 nM
COc1cccc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3933442 pIC50 6.026 nM
COc1cc(OC)cc(N(CC#Cc2cc(N)nc(C)n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3982399 pIC50 6.026 nM
COc1cc(OC)cc(N(CC#Cc2nccc(OC(C)C)n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3982718 pIC50 6.026 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(CCO)CC5)cc4)c3)c(OCCCOC)cc21 CHEMBL3691356 IC50 6.1 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(OCCN5CC(F)(F)C5)cc4)c3)ccc12 CHEMBL4293539 IC50 6.1 nM
COc1cc(OC)cc(N(C/C(C)=N\O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3948270 pIC50 6.166 nM
COc1cc(OC)cc(N(CC2CN(Cc3ccccc3)CCO2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3925610 pIC50 6.166 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(CC#Cc2ccncc2)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3943917 pIC50 6.166 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(C)CC5)cc4)c3)c(OCCCOC)cc21 CHEMBL3691358 IC50 6.2 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(NCC5(O)CCOCC5)cc4)c3)ccc12 CHEMBL4284153 IC50 6.2 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(N5CCN(C)CC5)nc4)n[nH]c3n2)c1Cl CHEMBL4533292 IC50 6.2 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(C3CN(CC)C3)cc2)c1 CHEMBL3686888 IC50 6.3 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 6.31 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)csc12 CHEMBL1982476 pKi 6.31 nM
CNC(=O)c1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCOC)c4)nc3c2)c1 CHEMBL3931674 pIC50 6.31 nM
COCCNc1cccc2[nH]c(C(=O)c3cnn(-c4ccc5[nH]c(C)nc5c4)c3N)cc12 CHEMBL3681281 IC50 6.4 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CCC[C@@H]5CO)s4)c3)c(OCCOC)cc21 CHEMBL3691312 IC50 6.4 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(C[C@H](C)O)CC5)cc4)c3)c(OCCCOC)cc21 CHEMBL3691354 IC50 6.4 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1C(=O)N[C@@H]1CCNC1=O CHEMBL4112606 IC50 6.4 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2c(-c3cnn(C)c3)n[nH]c2c1 CHEMBL4524697 IC50 6.4 nM
C=CC(=O)N1CCCC(n2nc3c(=O)[nH]nc(N)c3c2-c2oc3ccc(Cl)cc3c2C)C1 CHEMBL5268906 IC50 6.4 nM
COc1cc(OC)cc(N(CCC(=O)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3944224 pIC50 6.457 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4CCO)nc3c2)c1 CHEMBL3935838 pIC50 6.457 nM
COc1cc(OC)cc(N(CC#Cc2cc(C#N)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3952789 pIC50 6.457 nM
COc1cc(OC)cc(N(CC#Cc2cc(Cl)nc(N)n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3964762 pIC50 6.457 nM
C[C@H](Oc1ccc2[nH]nc(-c3nc4cc(CCO)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3827752 IC50 6.5 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CCC(O)CC5)s4)c3)c(OCCOC)cc21 CHEMBL3691316 IC50 6.5 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(C3CN(C)C3)cc2)c1 CHEMBL3691263 IC50 6.5 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCN(C(C)=O)CC1 CHEMBL3901861 IC50 6.5 nM
CCN(CC)c1cncc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(C)CC4)c(C(F)(F)F)c3)ccc2C)c1 CHEMBL4086340 IC50 6.5 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(Cc5ccc(C(=O)NO)cc5)c4)nc3c2)c1 CHEMBL5203230 IC50 6.5 nM
C=CC(=O)N1CCC(n2nc3c(=O)[nH]nc(N)c3c2-c2oc3cc(F)ccc3c2C)CC1 CHEMBL5284901 IC50 6.5 nM
Clc1cncc(Cl)c1COc1ccc2[nH]nc(-c3nc4cc(N5CCCCC5)ccc4[nH]3)c2c1 CHEMBL3827042 IC50 6.6 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(CN3CCC[C@@H]3CO)s2)c1 CHEMBL3691335 IC50 6.6 nM
COCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN[C@@H]1CCNC1=O CHEMBL4111992 IC50 6.6 nM
COc1cc(OC)cc(N(CC(O)CNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907047 pIC50 6.607 nM
COc1cc(OC)cc(N(CCCn2ccnc2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3969665 pIC50 6.607 nM
COc1cc(OC)cc(N(CC#Cc2nccs2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3977708 pIC50 6.607 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CC[C@@H](O)C5)s4)c3)c(OCCOC)cc21 CHEMBL3691315 IC50 6.7 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CN(C(C)C)C5)cc4)c3)c(OCCOC)cc21 CHEMBL3691318 IC50 6.7 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cncc2[nH]ccc12 CHEMBL4088977 IC50 6.7 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2c(-c3cnn(C4CCOC4)c3)n[nH]c2c1 CHEMBL4459160 IC50 6.7 nM
CCn1cc(-c2n[nH]c3cc(-c4cc(C(=O)Nc5cccc(C(F)(F)F)c5)ccc4C)ccc23)cn1 CHEMBL4535267 IC50 6.7 nM
CC#CC(=O)N1CCC(n2nc3c(=O)[nH]nc(N)c3c2-c2oc3ccc(C)cc3c2C)CC1 CHEMBL5287670 IC50 6.7 nM
COc1cc(F)cc(N(CCCN2CCC(C#N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3942811 pIC50 6.761 nM
COc1cc(O)cc(N(CCN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3903823 pIC50 6.761 nM
COc1cc(C)cc2cc(-c3c(CN4CCNC(=O)C4)c(CN4CCN(C=O)CC4)n4ncnc(N)c34)sc12 CHEMBL3974164 IC50 6.8 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1C(=O)N1CCC(O)C1 CHEMBL3976049 IC50 6.8 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1C(=O)N1CC(O)C1 CHEMBL3947786 IC50 6.8 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(C6CCN(C)CC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681270 IC50 6.9 nM
CCNCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCNCC1 CHEMBL3939941 IC50 6.9 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(C5CCN(C)CC5)cc4)n[nH]c3n2)c1Cl CHEMBL4467102 IC50 6.9 nM
CNC(=O)C(C)(C)n1cc(-c2cnc3ccc(N(CC4CC4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3948623 pIC50 6.918 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCCNCCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3973820 pIC50 6.918 nM
COc1cc(OC)cc(N(C/C(=N\O)C(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3982351 pIC50 6.918 nM
COc1cc(OC)cc(-c2cc3cnc(NCCCCN4CCOCC4)cc3nc2NC(=O)NC(C)(C)C)c1 CHEMBL187396 IC50 7.0 nM
CN1CCN(CCCNc2cc3nc(NC(=O)NC(C)(C)C)c(-c4c(Cl)cccc4Cl)cc3cn2)CC1 CHEMBL191389 IC50 7.0 nM
CCN(CC)CCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(-c3c(Cl)cccc3Cl)cc2cn1 CHEMBL365377 IC50 7.0 nM
CN1CCN(c2ccc3[nH]c(-c4c(N)c5cc(N)ccc5[nH]c4=O)nc3c2)CC1 CHEMBL496764 IC50 7.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2cc(F)cc(F)c2)c2nc(C)c[nH]2)C(=O)N3)CC1 CHEMBL2087168 IC50 7.0 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CN(C[C@H](C)O)C5)cc4)c3)c(OCCOC)cc21 CHEMBL3691311 IC50 7.0 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(C[C@@H](C)O)CC5)cc4)c3)c(OCCOC)cc21 CHEMBL3691320 IC50 7.0 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CN(C[C@@H](C)O)C5)cc4)c3)c(OCCCOC)cc21 CHEMBL3691346 IC50 7.0 nM
CCN1CCC(c2ccc(C(=O)Nc3cc(Oc4cc5ccn(C(=O)NC)c5cc4OCCCOC)ccn3)cc2)CC1 CHEMBL3691357 IC50 7.0 nM
CC(C)(O)CCn1cc(-c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)nn1 CHEMBL3956305 IC50 7.0 nM
Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 CHEMBL4798527 IC50 7.0 nM
COCCn1cc(-c2cnc3ccc(N(CC4CC4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3986163 pIC50 7.079 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CCO)c3)nc2c1 CHEMBL3893373 pIC50 7.079 nM
COc1cc(OC)cc(N(CCN2CCCC(C#N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3973587 pIC50 7.079 nM
CCn1ccnc1CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3936421 pIC50 7.079 nM
COc1cc(OC)cc(N(CCCNCC(F)(F)F)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3952866 pIC50 7.079 nM
COc1cc(OC)cc(N(CC#CC2CCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3986861 pIC50 7.079 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CN(C)C5)cc4)c3)c(OCCOC)cc21 CHEMBL3691317 IC50 7.1 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(C(C)C)CC5)cc4)c3)c(OCCCOC)cc21 CHEMBL3691355 IC50 7.1 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(C[C@H](C)O)CC5)cc4)c3)c(OC)cc21 CHEMBL3686866 IC50 7.2 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(C3CN(C[C@H](C)O)C3)cc2)c1 CHEMBL3691327 IC50 7.2 nM
COCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCNC(=O)C1 CHEMBL3963485 IC50 7.2 nM
C=CC(=O)NCCn1cc(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnc21 CHEMBL4559175 IC50 7.2 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(N5CCCN(C)CC5)cc4)n[nH]c3n2)c1Cl CHEMBL4593639 IC50 7.2 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCNS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3966022 pIC50 7.244 nM
COc1cc(OC)cc(N(CC#Cc2nccn2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3945845 pIC50 7.244 nM
COc1cc(OC)cc(N(CC2(OC)CCCNC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3891474 pIC50 7.244 nM
COc1cc(OC)cc(N(C[C@H](O)CNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3975397 pIC50 7.244 nM
COc1cc(OC)cc(N(CCN2CCN(C(=O)C3CC3)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3972617 pIC50 7.244 nM
CNC(=O)c1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907063 pIC50 7.244 nM
COc1cc(OC)cc(N(CCNC[Si](C)(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3893950 pIC50 7.244 nM
CC(=O)Nc1cc(-c2c(F)cccc2F)cc(-n2cnc3cc(-n4cccn4)ccc32)c1 CHEMBL3950320 IC50 7.3 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(OCC5(N)CC5)cc4)c3)ccc12 CHEMBL4290147 IC50 7.4 nM
COc1cc(OC)cc(N(C[C@@H](O)CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3967739 pIC50 7.413 nM
COc1cc(OC)cc(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1 CHEMBL4856613 IC50 7.5 nM
C=CCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3950262 pIC50 7.586 nM
COc1cc(OC)cc(N(CCCN2CCCC2=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3973321 pIC50 7.586 nM
COc1cc(OC)cc(N(Cc2nccn2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3927585 pIC50 7.586 nM
CC(Oc1ccc2[nH]nc(-c3nc4cc(N5CCCN(C)CC5)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3827594 IC50 7.6 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cncc(N2CCCC2)c1 CHEMBL4073474 IC50 7.6 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4csc(N5CCN(C)CC5)n4)c3)ccc12 CHEMBL4294660 IC50 7.6 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(N5CCOCC5)cc4)n[nH]c3n2)c1Cl CHEMBL4445710 IC50 7.7 nM
CCC#CC(=O)N1CCC(n2nc3c(=O)[nH]nc(N)c3c2-c2oc3ccc(C)cc3c2C)CC1 CHEMBL5277664 IC50 7.71 nM
COc1cc(O)cc(N(CCCNCC(F)(F)F)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3948755 pIC50 7.762 nM
COc1cc(OC)cc(N(CC#Cc2ccncc2C#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3979972 pIC50 7.762 nM
COc1ccnc(C#CCN(c2ccc3ncc(-c4cnn(C)c4)nc3c2)c2c(Cl)c(OC)cc(OC)c2Cl)n1 CHEMBL3953771 pIC50 7.762 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(N5CCN(C)CC5)cn4)n[nH]c3n2)c1Cl CHEMBL4450368 IC50 7.8 nM
COc1cc(CCc2cc(-c3nc4ccc(C(=O)N5CCOCC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5183691 IC50 7.84 nM
Cc1nc2c([nH]1)CCC(n1ncc(C(=O)c3cc4cc(CN5CCN(S(C)(=O)=O)CC5)ccc4[nH]3)c1N)=C2 CHEMBL3681289 IC50 7.9 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(CCO)CC5)cc4)c3)c(OC)cc21 CHEMBL3686865 IC50 7.9 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(CC(C)(C)O)CC5)cc4)c3)c(OC)cc21 CHEMBL3691280 IC50 7.9 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 pKi 7.943 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(C)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1984162 pKi 7.943 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 7.943 nM
Cc1cc(CNc2nccc(Nc3cc(CCc4ccccc4)[nH]n3)n2)on1 CHEMBL2088100 pIC50 7.943 nM
COc1cc(OC)cc(N(CC(C)(C)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3951156 pIC50 7.943 nM
COc1cc(OC)cc(N(CCCN2CCC(F)(F)C2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3986036 pIC50 7.943 nM
COc1cc(OC)cc(N(CCCN2CCC(F)(F)C2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3914615 pIC50 7.943 nM
COC/C(CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1)=N/O CHEMBL3892632 pIC50 7.943 nM
COc1cc(F)cc(N(CCCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3902110 pIC50 7.943 nM
COc1cc(OC)cc(N(CC(C)NCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3959260 pIC50 7.943 nM
COc1cc(O)cc(N(CCCNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3935177 pIC50 7.943 nM
COc1cc(OC)cc(-c2cc3cnc(NCCCCO)cc3nc2NC(=O)NC(C)(C)C)c1 CHEMBL425363 IC50 8.0 nM
CCN(CC)CCCNc1cc2nc(NC(=O)NC(C)(C)C)c(-c3cc(OC)cc(OC)c3)cc2cn1 CHEMBL363551 IC50 8.0 nM
CN1CCN(c2ccc3[nH]c(-c4c(N)c5ccccc5[nH]c4=O)nc3c2)CC1 CHEMBL204427 IC50 8.0 nM
c1ccc(COc2ccc3[nH]nc(-c4nc5cc(N6CCC(N7CCCCC7)CC6)ccc5[nH]4)c3c2)cc1 CHEMBL377346 IC50 8.0 nM
CN1CCN(c2ccc3[nH]c(-c4c(N)c5cc(NCc6ccccc6)ccc5[nH]c4=O)nc3c2)CC1 CHEMBL495735 IC50 8.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2cc(F)cc(F)c2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 CHEMBL2086757 IC50 8.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2nc(C)c[nH]2)c2ccccc2F)C(=O)N3)CC1 CHEMBL2087169 IC50 8.0 nM
CN[C@H]1CC2OC([C@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(O)=NC4 CHEMBL3975634 IC50 8.0 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(C3CN(CCO)C3)cc2)c1 CHEMBL3691258 IC50 8.0 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(C[C@H](C)O)CC5)cc4)c3)c(OCCCF)cc21 CHEMBL3691305 IC50 8.0 nM
CCOCc1c(CN2CCNC(=O)C2)c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn12 CHEMBL3973687 IC50 8.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 IC50 8.0 nM
CN1CCN(c2ccc3c(c2)N/C(=C2/C(=O)N=c4cccc(F)c4=C2N)N3)CC1 CHEMBL4578973 IC50 8.0 nM
CCn1cc(-c2cnc3ccc(N(CCNC(C)C)c4cc(OC)cc(OC)c4)cn3c2=O)cn1 CHEMBL4853985 IC50 8.0 nM
C=CC(=O)N1CCC(n2nc3c(=O)[nH]nc(N)c3c2-c2oc3ccc(C)cc3c2C)CC1 CHEMBL5290648 IC50 8.0 nM
CN1CCN(Cc2ccc(NC(=O)c3cc(C#Cc4cncc5ccccc45)ccn3)cc2C(F)(F)F)CC1 CHEMBL4089898 IC50 8.1 nM
[2H]C([2H])([2H])NC(=O)c1cncc(-c2cnn3cc(-c4ccn(C(C)C)n4)c(N[C@H]4CCOC4)nc23)c1 CHEMBL5175256 IC50 8.1 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCN)c4)nc3c2)c1 CHEMBL3956164 pIC50 8.128 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4c(C)nn(C)c4C)nc3c2)c1 CHEMBL3932817 pIC50 8.128 nM
COCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN[C@H]1CCNC1=O CHEMBL3951109 IC50 8.2 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1C(=O)N1CCC(O)CC1 CHEMBL3981692 IC50 8.2 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(N5C[C@@H](C)N[C@@H](C)C5)cc4)c3)c(OC)cc12 CHEMBL4279621 IC50 8.2 nM
C=CC(=O)Nc1cc(N2CCN(CC)CC2)ccc1Nc1cc2c(cn1)cc(-c1c(Cl)c(OC)cc(OC)c1Cl)c(=O)n2CC CHEMBL5180280 IC50 8.3 nM
CNC(=O)c1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3901420 pIC50 8.318 nM
COc1cc(OC)cc(N(CC#Cc2ncccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3975193 pIC50 8.318 nM
COc1cc(OC)cc(N(Cc2cc3ncccc3[nH]2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3939860 pIC50 8.318 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1C(N)=O CHEMBL3912904 IC50 8.4 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5c(NCCc6ccncc6)cccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681283 IC50 8.5 nM
CCN1CCC(c2ccc(C(=O)Nc3cc(Oc4cc5ccn(C(=O)NC)c5cc4OCCCF)ccn3)cc2)CC1 CHEMBL3691264 IC50 8.5 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(C[C@@H](C)O)CC5)cc4)c3)c(OCCCF)cc21 CHEMBL3691304 IC50 8.5 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CN(CC(C)(C)O)C5)cc4)c3)c(OCCOC)cc21 CHEMBL3691309 IC50 8.5 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CN(C[C@@H](C)O)C5)cc4)c3)c(OCCOC)cc21 CHEMBL3691310 IC50 8.5 nM
CCN1CC(c2ccc(C(=O)Nc3cc(Oc4cc5ccn(C(=O)NC)c5cc4OCCCOC)ccn3)cc2)C1 CHEMBL3691352 IC50 8.5 nM
NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)NCCCCN1CCCC1 CHEMBL253969 IC50 8.5 nM
COc1cc(OC)cc(N(CCN2C[C@@H](C)O[C@@H](C)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3951728 pIC50 8.511 nM
COc1cc(OC)cc(N(CC2CCOCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3956120 pIC50 8.511 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CC[C@H](O)C5)s4)c3)c(OCCOC)cc21 CHEMBL3691314 IC50 8.6 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(CN3CC[C@H](O)C3)cc2)c1 CHEMBL3691330 IC50 8.6 nM
CCN(CC)Cc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCNCC1 CHEMBL3897866 IC50 8.6 nM
CC(C)Oc1cc(-n2cnc3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 CHEMBL2151321 IC50 8.7 nM
CCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(C3CCN(C(C)C)CC3)cc2)c1 CHEMBL3691289 IC50 8.7 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCNC(=O)C1C CHEMBL3927292 IC50 8.7 nM
COc1cc(OC)cc(N(CCCN2CCC(F)(F)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3950907 pIC50 8.71 nM
COc1cc(OC)cc(N(CCN2CCOCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3982668 pIC50 8.71 nM
COc1cc(F)cc(N(CCO)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3981077 pIC50 8.71 nM
COc1cc(OC)cc(N(CC#CC2(O)CCNC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3941227 pIC50 8.71 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1C(=O)N1CNC(=O)C1 CHEMBL3934358 IC50 8.8 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(N)cc4)n[nH]c3n2)c1Cl CHEMBL4464372 IC50 8.8 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(N5CCCCC5)cc4)n[nH]c3n2)c1Cl CHEMBL4569919 IC50 8.8 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(C(C)C)CC5)cc4)c3)c(OC)cc21 CHEMBL3691281 IC50 8.9 nM
CCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(C3CCN(C[C@H](C)O)CC3)cc2)c1 CHEMBL3691291 IC50 8.9 nM
CCOCCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(CN3CC[C@@H](O)C3)cc2)c1 CHEMBL3691338 IC50 8.9 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CN(C(C)C)C5)cc4)c3)c(OCCCOC)cc21 CHEMBL3691351 IC50 8.9 nM
COc1cc(OC)cc(N(Cc2ccc(Cl)s2)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3986661 pIC50 8.913 nM
COc1cc(OC)cc(N(CC#Cc2cc(C)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3983694 pIC50 8.913 nM
COc1cc(OC)cc(N(CCCc2cc(C)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3939332 pIC50 8.913 nM
COc1cc(OC)cc(-c2cc3cnc(NCCCCCN4CCOCC4)cc3nc2NC(=O)NC(C)(C)C)c1 CHEMBL191070 IC50 9.0 nM
CN1CCN(Cc2ccc3[nH]c(-c4c(N)c5ccccc5[nH]c4=O)nc3c2)CC1 CHEMBL495961 IC50 9.0 nM
Cc1nc2cc(-n3ncc(C(=O)C4=CC5C=CC(C#N)=CC5N4)c3N)ccc2[nH]1 CHEMBL3681264 IC50 9.0 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1C(=O)N1CCS(=O)(=O)C1 CHEMBL3977038 IC50 9.0 nM
Cn1cc(-c2ccc3c(c2)ncn3-c2cc(Nc3nccs3)cc(-c3ccc(F)cc3F)c2)cn1 CHEMBL3899205 IC50 9.0 nM
CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1 CHEMBL3545085 Kd apparent 9.0 nM
C=CC(=O)N1CC(n2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)nc(Cl)nc32)C1 CHEMBL4437175 IC50 9.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2c(-c3ccc(N4CCC(N5CCOCC5)CC4)cc3)n[nH]c2c1 CHEMBL4587973 IC50 9.0 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC(C)(C)O)c4)nc3c2)c1 CHEMBL3915235 pIC50 9.12 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC(O)CO)c4)nc3c2)c1 CHEMBL3889493 pIC50 9.12 nM
COc1cc(F)cc(N(CCCO)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3897034 pIC50 9.12 nM
CCc1c(-c2cnc3ccc(N(CCO)c4cc(OC)cc(OC)c4)cc3n2)cnn1C CHEMBL3986725 pIC50 9.12 nM
COc1cc(OC)c(F)c(N2Cc3cnc4c(c3N(c3ccc(C#N)cc3)C2=O)CC(=O)N4)c1F CHEMBL4871046 IC50 9.2 nM
CS(=O)(=O)Nc1cc(-c2ncccc2F)cc(-n2cnc3cc(-c4cnn(CCN5CCOCC5)c4)ccc32)c1 CHEMBL3975520 IC50 9.3 nM
COc1cc(OC)cc(N(C[C@H](O)CN2CC[C@H](C#N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3980252 pIC50 9.333 nM
C[C@H](Oc1ccc2[nH]nc(-c3nc4cc(N5CCN(C)CC5)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3828022 IC50 9.4 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1C(=O)N1CCNC(=O)C1 CHEMBL3921890 IC50 9.4 nM
C=CC(=O)N(C)c1cccc(CCn2c(=O)c(-c3cc(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)c1 CHEMBL4068712 IC50 9.4 nM
COc1cc(OC)cc(N(Cc2nnc(NCCO)o2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3977904 pIC50 9.55 nM
COCCN(CCOC)Cc1ccc2cc(C(=O)C3C=NN(c4ccc5[nH]c(C)nc5c4)C3N)[nH]c2c1 CHEMBL3676326 IC50 9.6 nM
CCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(C3CCN(C[C@@H](C)O)CC3)cc2)c1 CHEMBL3691290 IC50 9.6 nM
COc1cc(C)cc2cc(-c3c(CN4CCNC(=O)C4)c(CN4CCOCC4)n4ncnc(N)c34)sc12 CHEMBL3921263 IC50 9.7 nM
COc1cc(CCc2cc(-c3nc4ccc(C(=O)N5CCN(C)CC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5183603 IC50 9.7 nM
COc1cc(OC)cc(N(CCN2CCN(C(C)=O)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3981076 pIC50 9.772 nM
CNC(=O)c1cc(F)cc(N(CC(C)(C)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3951090 pIC50 9.772 nM
Cc1ccc(N2CCC(O)CC2)nc1C(=O)Nc1c(C)cc(C(=O)O)cc1C CHEMBL3686863 IC50 9.8 nM
CCOc1cc2c(ccn2C(=O)NC)cc1Oc1ccnc(NC(=O)c2ccc(C3CCN(CC(C)(C)O)CC3)cc2)c1 CHEMBL3639901 IC50 9.8 nM
COc1cc(OC)c(F)c(N2Cc3cnc4c(c3N(C)C2=O)C(C)(C)C(=O)N4)c1F CHEMBL4858423 IC50 9.8 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1C(C)O CHEMBL3889482 IC50 9.9 nM
Nc1ncnc2c1c(-c1cc(C(F)(F)F)cc(C(F)(F)F)c1)nn2CCCCCN1CCN(C(=O)/C=C/C(F)(F)F)CC1 CHEMBL5077247 IC50 9.9 nM
C=CC(=O)N1CCC(c2cc3c(Oc4ccc(NC(=O)NC5CC5)c(Cl)c4)ccnc3cc2OC)CC1 CHEMBL5439595 IC50 9.9 nM