C=CC(=O)Nc1ccc(/C=C/c2nc(Nc3cc(C(C)C)[nH]n3)cc(N3CCN(C)CC3)n2)cc1 CHEMBL4776177 GI50 0.1 nM
COc1cc(CCc2cc(-c3nc4ccc(N5C[C@@H](C)O[C@@H](C)C5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5173892 IC50 0.11 nM
COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1F CHEMBL4870179 IC50 0.15 nM
COc1cc(CCc2cc(Nc3ncnc4cc(N5C[C@@H](C)N(C)[C@@H](C)C5)ccc34)n[nH]2)cc(OC)c1 CHEMBL3798625 IC50 0.2 nM
COc1cc(CCc2cc(Nc3ncnc4cc(N5CCN6CCCCC6C5)ccc34)n[nH]2)cc(OC)c1 CHEMBL3800526 IC50 0.2 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)c(=O)n3c2)c1 CHEMBL4862576 IC50 0.2 nM
[2H]C([2H])([2H])NC(=O)c1cncc(-c2cnn3cc(-c4ccn(C(C)C)n4)c(N[C@H]4CCOC4)nc23)c1 CHEMBL5175256 IC50 0.2 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3nc(-c4cnn(C)c4)cnc3c2)c1 CHEMBL5189383 IC50 0.2 nM
C[C@@H](Oc1ccc2[nH]nc(/C=C/c3cnn(CCO)c3)c2c1)c1c(Cl)cncc1Cl CHEMBL3828009 IC50 0.26 nM
COc1cc(CCc2cc(-c3nc4cc(F)c(N5CCOCC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5171314 IC50 0.27 nM
COc1cc(CCc2cc(-c3nc4cc(F)c(N5C[C@@H](C)O[C@@H](C)C5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5179660 IC50 0.29 nM
COc1cc(CCc2cc(Nc3ncnc4cc(N5CCC(N(C)C)CC5)ccc34)n[nH]2)cc(OC)c1 CHEMBL3797845 IC50 0.3 nM
CCN1CCN(c2ccc3c(Nc4cc(CCc5c(Cl)c(OC)cc(OC)c5Cl)[nH]n4)ncnc3c2)CC1 CHEMBL3797507 IC50 0.3 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(C#Cc4cncc(N5CCOCC5)c4)c3)cc2C(F)(F)F)CC1 CHEMBL4091628 IC50 0.3 nM
C=CC(=O)N1CCC(C2CCN(c3nc(Nc4cc(C(C)C)[nH]n4)cc(N4CCN(C)CC4)n3)CC2)C1 CHEMBL4755567 GI50 0.3 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1F CHEMBL4862823 IC50 0.3 nM
COc1cc(CCc2cc(Nc3ncnc4cc(N5CCOCC5)ccc34)n[nH]2)cc(OC)c1 CHEMBL3798342 IC50 0.4 nM
COc1cc(CCc2cc(Nc3ncnc4cc(N5CCC(N(C)C)C5)ccc34)n[nH]2)cc(OC)c1 CHEMBL3797594 IC50 0.4 nM
C#C[C@@H]1C[C@H](n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)CN1C(=O)C=C CHEMBL3701256 IC50 0.4 nM
C=CC(=O)N1CC[C@H](n2cc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701258 IC50 0.4 nM
COc1cc(CCc2cc(NC(=O)c3ccc(N4C[C@@H](C)N[C@@H](C)C4)cc3)n[nH]2)cc(OC)c1 CHEMBL3348846 IC50 0.4 nM
CCN1C(=O)N(c2c(F)c(OC)cc(OC)c2F)Cc2cnc3[nH]c(CN4CCOCC4)cc3c21 CHEMBL4297522 IC50 0.4 nM
COc1cc(OC)c(Cl)c(CCc2cc(-c3nc4ccc(N5CCN(C)CC5)cc4[nH]3)n[nH]2)c1Cl CHEMBL5205436 IC50 0.43 nM
COc1cc(CCc2cc(-c3nc4cc(F)c(N5CCN(C)CC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5189958 IC50 0.437 nM
COc1cc(OC)c(F)c(COc2cnc(Nc3cnn(CCO)c3)nc2)c1F CHEMBL4594428 IC50 0.47 nM
CCc1nc(Nc2cc(CCc3cc(OC)cc(OC)c3)[nH]n2)c2ccc(N3CCN(CC)CC3)cc2n1 CHEMBL3797416 IC50 0.5 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(CCO)CC5)cc4)c3)c(OCCO)cc21 CHEMBL4294625 IC50 0.5 nM
COc1cc(CCc2cc(-c3nc4ccc(N5CCN(C)CC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5199374 IC50 0.5 nM
COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3ccc(N4C[C@@H](C)N[C@@H](C)C4)cc3)n2)c1Cl CHEMBL5177100 IC50 0.52 nM
COc1cc(CCc2cc(Nc3ncnc4cc(N5CCN(C6CCC6)CC5)ccc34)n[nH]2)cc(OC)c1 CHEMBL3799426 IC50 0.6 nM
COc1cc(CCc2cc(Nc3ncnc4cc(N5CCN(C(C)C)CC5)ccc34)n[nH]2)cc(OC)c1 CHEMBL3799403 IC50 0.6 nM
CCN1CCN(c2ccc3c(Nc4cc(CCc5cc(OC)cc(OC)c5)[nH]n4)nc(C)nc3c2)CC1 CHEMBL3799611 IC50 0.6 nM
CCN1CCN(c2ccc3c(Nc4cc(CCc5cc(OC)cc(OC)c5)[nH]n4)nc(Cl)nc3c2)CC1 CHEMBL3799093 IC50 0.6 nM
COc1cc(C#Cc2cn(C3CN(C(=O)/C=C/CN4CCCC4)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701268 IC50 0.6 nM
C=CC(=O)N1CCC(c2ccc(-c3nc(Nc4cc(C(C)C)[nH]n4)cc(N4CCN(C)CC4)n3)cc2)CC1 CHEMBL4755774 GI50 0.6 nM
CCN1CCN(c2cccc(Nc3ncnc(-c4cccnc4Nc4c(Cl)c(OC)cc(OC)c4Cl)n3)c2)CC1 CHEMBL5198569 IC50 0.6 nM
COc1cc(OC)c(Cl)c(CCc2cc(-c3nc4ccc(CN5CCN(C)CC5)cc4[nH]3)n[nH]2)c1Cl CHEMBL5177815 IC50 0.63 nM
CCN1CCN(c2ccc(Nc3cc(N(C)C(=O)Nc4c(Cl)c(OC)cc(OC)c4Cl)ncn3)cc2)CC1 CHEMBL1852688 IC50 0.68 nM
COc1cc(CCc2cc(Nc3ncnc4cc(N5CCCN(C)CC5)ccc34)n[nH]2)cc(OC)c1 CHEMBL3797998 IC50 0.7 nM
COCCN1CCN(c2ccc3c(Nc4cc(CCc5cc(OC)cc(OC)c5)[nH]n4)ncnc3c2)CC1 CHEMBL3798940 IC50 0.7 nM
CCCc1nc(Nc2cc(CCc3cc(OC)cc(OC)c3)[nH]n2)c2ccc(N3CCN(CC)CC3)cc2n1 CHEMBL3799885 IC50 0.7 nM
COc1cc(CCc2cc(Nc3ncnc4cc(N5CCN(C)CC5)ccc34)n[nH]2)cc(OC)c1 CHEMBL3799354 IC50 0.7 nM
COCCN1CCN(c2ccc(C(=O)Nc3n[nH]c4nc(-c5c(Cl)c(OC)cc(OC)c5Cl)ccc34)cc2)CC1 CHEMBL4447359 IC50 0.7 nM
COc1cc(OC)cc(-c2nn(CCCCCN3CCN(C(=O)/C=C/C(F)(F)F)CC3)c3ncnc(N)c23)c1 CHEMBL5088737 IC50 0.7 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.757 nM
COc1cc(CCc2cc(Nc3ncnc4cc(C5CCN(C)CC5)ccc34)n[nH]2)cc(OC)c1 CHEMBL3800072 IC50 0.8 nM
CCN1CCN(c2ccc3c(Nc4cc(CCc5cc(OC)cc(OC)c5)[nH]n4)ncnc3c2)CC1 CHEMBL3798997 IC50 0.8 nM
C=CC(=O)N1CC[C@H](n2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnc32)C1 CHEMBL4475243 IC50 0.8 nM
COc1cc(CCc2cc(-c3nc4ccc(CN5CCOCC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5191338 IC50 0.81 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4096041 IC50 0.84 nM
COc1cc(CCc2cc(-c3nc4ccc(CN5CCN(C)CC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5174735 IC50 0.84 nM
COc1cc(CCc2cc(-c3nc4ccc(CN5CCC(N6CCN(C)CC6)CC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5186357 IC50 0.89 nM
COc1cc(OC)cc(N(CCCNCC(N)=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3960877 pIC50 0.8913 nM
COCCOc1ccc2c(Nc3cc(CCc4cc(OC)cc(OC)c4)[nH]n3)ncnc2c1 CHEMBL3798532 IC50 0.9 nM
COc1cc(CCc2cc(Nc3ncnc4cc(N5CCNC(C)(C)C5)ccc34)n[nH]2)cc(OC)c1 CHEMBL3798911 IC50 0.9 nM
C=CC(=O)N1CCC2(CCN(c3nc(Nc4cc(C(C)C)[nH]n4)cc(N4CCN(C)CC4)n3)CC2)C1 CHEMBL4779534 GI50 0.9 nM
C=CC(=O)N1CCC(c2ccc(-c3nc(Nc4cc(C5COC5)[nH]n4)cc(N4CCN(C)CC4)n3)cc2)CC1 CHEMBL4791200 GI50 0.9 nM
COc1cc(CCc2cc(-c3nc4ccc(N5CCOCC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5207255 IC50 0.915 nM
CCN1CCN(c2ccc(Nc3ncnc(-c4cccnc4Nc4c(Cl)c(OC)cc(OC)c4Cl)n3)cc2)CC1 CHEMBL5179166 IC50 0.92 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 IC50 1.0 nM
COc1cc(C#Cc2cn(C3CN(C(=O)/C=C/CN(C)C)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701267 IC50 1.0 nM
COc1cc(C#Cc2cn(C3CN(C(=O)/C=C/CN4CC[C@@H](O)C4)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701275 IC50 1.0 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1Cl CHEMBL4863146 IC50 1.0 nM
O=C(NC1CC1)c1c[nH]nc1-c1nc2cc(CN3CCOCC3)ccc2[nH]1 CHEMBL5186648 IC50 1.0 nM
[2H]C([2H])([2H])NC(=O)c1cncc(-c2cnn3cc(-c4cnn(C(C)C)c4)c(O[C@H]4CCOC4)nc23)c1 CHEMBL5180631 IC50 1.0 nM
C=CC(=O)N1CC[C@H](n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701238 IC50 1.0 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCC#N)c4)nc3c2)c1 CHEMBL3958209 pIC50 1.047 nM
COc1cc(CCc2cc(-c3nc4ccc(C(=O)NC5CCOCC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5183701 IC50 1.07 nM
C#CC(=O)N1CC[C@H](n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701239 IC50 1.1 nM
C=CC(=O)N1CC(n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701241 IC50 1.1 nM
C=CC(=O)Nc1ccc(-n2nc3c(=O)[nH]nc(N)c3c2-c2oc3ccc(Cl)cc3c2C)cc1 CHEMBL4467025 IC50 1.1 nM
C=CC(=O)N1CC[C@H](c2nc(-c3cc4cc(Br)cc(OC)c4s3)c3c(N)nccn23)C1 CHEMBL5271030 IC50 1.1 nM
COc1cc(OC)cc(N(CCCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3934260 pIC50 1.122 nM
COc1cc(OC)cc(N(CCCN)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3966748 pIC50 1.175 nM
CCN1CCN(c2ccc3c(Nc4cc(CCc5cc(OC)cc(OC)c5)[nH]n4)nccc3c2)CC1 CHEMBL3800415 IC50 1.2 nM
COc1cc(C#Cc2nn(C3CN(C(=O)C#CCO)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701242 IC50 1.2 nM
CCN(CC)C/C=C/C(=O)N1CC(n2cc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701271 IC50 1.2 nM
C=CC(=O)N1C[C@@H](n2cc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C[C@H]1c1nnco1 CHEMBL3701279 IC50 1.2 nM
COc1cc(Nc2ncc(CCc3c(F)c(OC)cc(OC)c3F)cn2)ccc1N1CCC(N2CCN(C)CC2)CC1 CHEMBL4763773 IC50 1.2 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCCCCC(=O)NO)c4)nc3c2)c1 CHEMBL5177696 IC50 1.2 nM
COc1ccc(Nc2ncc3c(n2)N(C2CCN(C(=O)/C=C/CN(C)C)CC2)C(=O)N(c2c(Cl)c(OC)cc(OC)c2Cl)C3)cc1 CHEMBL4100258 IC50 1.21 nM
COc1cc(OC)cc(N(CCCN2CC=CCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3919479 pIC50 1.259 nM
COc1cc(CCc2cc(Nc3ncnc4cc(NCCN5CCOCC5)ccc34)n[nH]2)cc(OC)c1 CHEMBL3800352 IC50 1.3 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 IC50 1.3 nM
C=CC(=O)N1CCN(CCCn2c(=O)c(-c3c(Cl)c(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)CC1 CHEMBL4068509 IC50 1.3 nM
C=CC(=O)N1CC2(CCN(c3nc(Nc4cc(C(C)C)[nH]n4)cc(N4CCN(C)CC4)n3)CC2)C1 CHEMBL4783883 GI50 1.3 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(N5CCNC(C)(C)C5)cc4)n[nH]c3n2)c1Cl CHEMBL5269917 IC50 1.3 nM
COc1cc(CCc2cc(-c3nc4ccc(-c5ccc(C(=O)N6CCOCC6)cc5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5192921 IC50 1.35 nM
COc1cc(OC)cc(N(CCCN2CCCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3904674 pIC50 1.38 nM
COc1cc(OC)cc(N(CCCN2CCC[C@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3936672 pIC50 1.38 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4088313 IC50 1.39 nM
CCN1CCN(c2ccc(Nc3cc(N(C)C(=O)Nc4c(Cl)c(OC)cc(OC)c4Cl)ncn3)cc2)CC1 CHEMBL1834657 IC50 1.4 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1 CHEMBL4847441 IC50 1.4 nM
COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1 CHEMBL4863224 IC50 1.4 nM
COc1cc(OC)cc(N(CCCNCCC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3899151 pIC50 1.413 nM
C=CC(=O)N1CCN(CCCCCn2nc(-c3cc(OC)cc(OC)c3)c3c(N)ncnc32)CC1 CHEMBL5084546 IC50 1.42 nM
CCS(=O)(=O)NCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3912569 pIC50 1.445 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(F)cc4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4092508 IC50 1.45 nM
CNC(=O)c1ncc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(CCO)CC4)c(C(F)(F)F)c3)ccc2C)n1C CHEMBL1784637 IC50 1.5 nM
COc1cc(C#Cc2cn(C3CN(C(=O)/C=C/CNC(C)C)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701270 IC50 1.5 nM
COCCN(C)C/C=C/C(=O)N1CC(n2cc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701272 IC50 1.5 nM
C=CC(=O)Nc1ccc(-n2nc3c(=O)[nH]nc(N)c3c2-c2oc3ccc(C)cc3c2C)cc1 CHEMBL4446835 IC50 1.5 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3545376 IC50 1.5 nM
COc1cc(CCc2cc(-c3nc4ccc(CN5CCC(N6CCNCC6)CC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5201819 IC50 1.51 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCCN)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3942328 pIC50 1.514 nM
COc1cc(OC)cc(N(CCCN2CC(O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907314 pIC50 1.549 nM
COc1cc(OC)cc(N(CCCN2CCCC(C(N)=O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3910444 pIC50 1.549 nM
COc1cccc(Nc2ncc3c(n2)N(C2CCN(C(=O)/C=C/CN(C)C)CC2)C(=O)N(c2c(Cl)c(OC)cc(OC)c2Cl)C3)c1 CHEMBL4068733 IC50 1.58 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3931421 pIC50 1.585 nM
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(F)ccc3O)cc12 CHEMBL4062877 IC50 1.6 nM
CNc1ncc2c(n1)N(C1CCN(C(=O)/C=C/CN(C)C)CC1)C(=O)N(c1c(Cl)c(OC)cc(OC)c1Cl)C2 CHEMBL4092354 IC50 1.62 nM
C#CCN(c1ccc2ncc(-c3cnn(C)c3)nc2c1)c1c(F)c(OC)cc(OC)c1F CHEMBL3935597 pIC50 1.622 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4cccc(C)c4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4103795 IC50 1.65 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3918092 pIC50 1.66 nM
COc1cc(OC)cc(N(CC(F)CN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3908149 pIC50 1.66 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3893786 pIC50 1.698 nM
COc1cc(OC)cc(N(CCCN2CCC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3906894 pIC50 1.738 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C([2H])([2H])C([2H])([2H])NC(C)C)c1 CHEMBL3918638 pIC50 1.738 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4cccc(F)c4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4079538 IC50 1.77 nM
COc1cc(OC)cc(N(CCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3985222 pIC50 1.778 nM
CNCCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3968499 pIC50 1.778 nM
CCn1cc(-c2cnc3ccc(N(CCNC(C)C)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3945159 pIC50 1.778 nM
CNC[C@@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3965710 pIC50 1.778 nM
CNC[C@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3968124 pIC50 1.778 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)[C@H]2CC[C@@H](NC(C)C)CC2)c1 CHEMBL3911621 pIC50 1.778 nM
CN1C[C@@H]2CC[C@H](C1=O)N2c1ncc2[nH]nc(-c3cnn(C4CCC4)c3)c2n1 CHEMBL5286909 IC50 1.8 nM
COc1cc(OC)cc(N(CCNS(=O)(=O)N(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3919173 pIC50 1.82 nM
CCCn1cc(-c2cnc3ccc(N(CCN)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3959573 pIC50 1.82 nM
COc1cc(OC)cc(N(CCNS(=O)(=O)C(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3964574 pIC50 1.82 nM
COc1cc(OC)cc(N(C[C@@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3913322 pIC50 1.82 nM
CCN1CCN(c2ccc(Nc3cc(-c4cccnc4Nc4c(Cl)c(OC)cc(OC)c4Cl)ncn3)cc2)CC1 CHEMBL5194218 IC50 1.83 nM
COc1cc(OC)cc(N(CCCN2CCC(F)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3975447 pIC50 1.862 nM
COc1cc(F)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3918739 pIC50 1.862 nM
COc1cc(OC)cc(N(CCCN2CCC[C@@H]2CC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3948744 pIC50 1.862 nM
Cc1ccc2oc(-c3c4c(N)n[nH]c(=O)c4nn3-c3ccc(NC(=O)/C=C/CN(C)C)cc3)c(C)c2c1 CHEMBL4463714 IC50 1.9 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCOc5ccc(C(=O)NO)cc5)c4)nc3c2)c1 CHEMBL5181688 IC50 1.9 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(N5CCN(CCO)CC5)cc4)c3)ccc12 CHEMBL4278642 IC50 1.9 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3955563 pIC50 1.905 nM
COc1cc(OC)cc(N(Cc2ncc[nH]2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3928393 pIC50 1.905 nM
COc1cc(OC)cc(N(C[C@@H](O)CNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3903811 pIC50 1.905 nM
COc1cc(OC)cc(N(CCCN2CCCC2(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3968818 pIC50 1.905 nM
CCN1CCN(C(=O)c2ccc3nc(-c4cc(CCc5cc(OC)cc(OC)c5)[nH]n4)[nH]c3c2)CC1 CHEMBL5191301 IC50 1.93 nM
COc1cc(OC)cc(N(CCCN2CCC(O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3984039 pIC50 1.95 nM
COc1cc(OC)cc(N(CCCN2CCC(N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3919730 pIC50 1.95 nM
COc1cc(OC)cc(N(CCCN)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3922698 pIC50 1.95 nM
COc1cc(OC)cc(N(CCCN2[C@@H](C)CC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3968139 pIC50 1.95 nM
COc1cc(OC)cc(N(CC(=O)Nc2cc(O)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3894762 pIC50 1.95 nM
COc1cc(OC)cc(N(CCN2CCC(N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3983996 pIC50 1.995 nM
COc1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3951694 pIC50 1.995 nM
COc1cc(OC)cc(N(CCNCC(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3905866 pIC50 1.995 nM
COc1cc(OC)cc(N(CCN2CCC[C@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3943860 pIC50 1.995 nM
Cn1cc(Nc2ncc(Br)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)cn1 CHEMBL2071201 IC50 2.0 nM
C[C@@H](Oc1ccc2[nH]nc(-c3nc4cc(N5CCN(C)CC5)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3827178 IC50 2.0 nM
COc1cc(C#Cc2cn([C@H]3CCN(C(=O)C#CC(C)(C)O)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701262 IC50 2.0 nM
OC[C@H](Nc1cnc(-c2cc(Cl)ccc2O)c(-c2ccc3cnccc3c2)c1)c1ccccc1 CHEMBL4067871 IC50 2.0 nM
CCN1CCN(c2ccc(C(=O)Nc3n[nH]c4cc(-c5c(F)ccc(OC)c5F)ccc34)cc2)CC1 CHEMBL4105407 IC50 2.0 nM
COc1ccc(F)c(-c2ccc3c(NC(=O)c4ccc(N5CCCN(C)CC5)cc4)n[nH]c3c2)c1F CHEMBL4086560 IC50 2.0 nM
Cc1c(-c2c3c(N)n[nH]c(=O)c3nn2-c2ccc(NC(=O)/C=C/CN(C)C)cc2)oc2ccc(Br)cc12 CHEMBL4448252 IC50 2.0 nM
COc1cc(OC)cc(N(CCCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3909529 pIC50 2.042 nM
COc1cc(OC)cc(N(CCCN2CCC[C@@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3942763 pIC50 2.042 nM
COc1cc(OC)cc(N(CCC(=O)NCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3937972 pIC50 2.042 nM
COc1cc(OC)cc(N(CCCN2CCC(N3CCCCC3)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3971277 pIC50 2.089 nM
COc1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cnn(CC5CCOCC5)c4)nc3c2)c1 CHEMBL3966305 pIC50 2.089 nM
COc1cc(F)cc(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3974206 pIC50 2.089 nM
COc1cc(CCc2cc(-c3nc4ccc(C(=O)N5CCN(C)CC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5183603 IC50 2.13 nM
COc1cc(OC)cc(N(CCN2CCC(O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3959345 pIC50 2.138 nM
COc1cc(OC)cc(N(CCCN2CCC[C@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3949132 pIC50 2.138 nM
COc1cc(OC)cc(N(CCCN2CCOCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3928261 pIC50 2.138 nM
COc1cc(OC)cc(N(Cc2cnccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3890378 pIC50 2.138 nM
COc1cc(OC)cc(N(CCN2CC=CCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3979670 pIC50 2.138 nM
COc1cc(CCc2cc(-c3nc4ccc(C(=O)N5CCOCC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5183691 IC50 2.18 nM
COc1cc(CCc2cc(-c3nc4ccc(C(=O)NCCN5CCOCC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5181778 IC50 2.18 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CC5CCOCC5)c4)nc3c2)c1 CHEMBL3926082 pIC50 2.188 nM
CCN(CCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1)C(C)C CHEMBL3944320 pIC50 2.188 nM
COc1cc(C#Cc2nn(C3CN(C(=O)/C=C/CN(C)C)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701243 IC50 2.2 nM
C=CC(=O)Nc1ccccc1C(=O)Nc1cc(CCc2cc(OC)cc(OC)c2)[nH]n1 CHEMBL4284069 IC50 2.2 nM
C=CC(=O)N1CCN(CCCCCCCn2nc(-c3cc(OC)cc(OC)c3)c3c(N)ncnc32)CC1 CHEMBL5091141 IC50 2.2 nM
COc1cc(OC)cc(N(CCN2CCCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3957264 pIC50 2.239 nM
CNC1CCN(CCCN(c2cc(OC)cc(OC)c2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)C1 CHEMBL3922453 pIC50 2.239 nM
COc1cc(OC)cc(N(CCCN2CCC(C(F)(F)F)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3936087 pIC50 2.239 nM
COc1cc(OC)cc(N(CCNCCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3944610 pIC50 2.239 nM
COc1cc(OC)cc(N(Cc2cccnc2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3928239 pIC50 2.239 nM
C=CC(=O)Nc1cccc(CN2C(=O)N(c3c(Cl)c(OC)cc(OC)c3Cl)Cc3cnc(NCCCCN(CC)CC)nc32)c1 CHEMBL2216830 IC50 2.29 nM
[2H]C([2H])([2H])n1cc(-c2cnc3ccc(N(CCNC(C)C)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3919709 pIC50 2.291 nM
COc1cc(OC)cc(N(CCC2CCN(C(C)C)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3970423 pIC50 2.291 nM
COc1cc(OC)cc(N(CCCN)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3979013 pIC50 2.291 nM
COc1cc(C#Cc2cn(C3CN(C(=O)/C=C/CN4CCC(O)CC4)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701273 IC50 2.3 nM
COc1cc(OC)cc(N(CCC#N)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3913757 pIC50 2.344 nM
COc1cc(OC)cc(N(CC#CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3895267 pIC50 2.344 nM
COc1cc(CCc2cc(-c3nc4ccc(CN5C[C@@H](C)N[C@@H](C)C5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5180534 IC50 2.35 nM
COc1cc(CCc2cc(-c3nc4ccc(N5C[C@@H](C)N[C@@H](C)C5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5182544 IC50 2.35 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCOCC4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4060079 IC50 2.39 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CC(=O)NC)c3)nc2c1 CHEMBL3909140 pIC50 2.399 nM
COc1cc(OC)cc(N(CCN2CCC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3939200 pIC50 2.399 nM
COc1cc(OC)cc(N(CCN2CCCC(C(N)=O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3931790 pIC50 2.399 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)[C@H]2CC[C@H](NC(C)C)CC2)c1 CHEMBL3918800 pIC50 2.399 nM
C=CC(=O)N1CCC(n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701237 IC50 2.4 nM
COc1cc(OC)cc(N(CCCC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3955706 pIC50 2.455 nM
COc1cc(OC)cc(N(CCN2CCCC2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3969815 pIC50 2.455 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3970430 pIC50 2.455 nM
COc1cc(OC)cc(N(CCN2CCC[C@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907195 pIC50 2.455 nM
COc1cc(OC)cc(N(C[C@H](O)CNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3941695 pIC50 2.455 nM
COc1cc(O)cc(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3964096 pIC50 2.455 nM
COc1cc(C#Cc2cn(C3CN(C(=O)/C=C/CN4CCC4)C3)c3ncncc23)cc(OC)c1 CHEMBL3701269 IC50 2.5 nM
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cccc(F)c3O)cc12 CHEMBL4076118 IC50 2.5 nM
COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3ccccc3)n2)c1Cl CHEMBL5203040 IC50 2.51 nM
COc1cc(OC)cc(N(CCN2CCCCC2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3943043 pIC50 2.512 nM
COc1cc(OC)cc(N(CCCN2CCCCC2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3905485 pIC50 2.512 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3892776 pIC50 2.512 nM
CCn1cc(-c2cnc3ccc(N(CCN)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3950089 pIC50 2.512 nM
COc1cc(OC)cc(N(CCCN2[C@H](C)CC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3902353 pIC50 2.512 nM
COc1cc(OC)cc(N(C[C@@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(CCCN)c4)nc3c2)c1 CHEMBL3964701 pIC50 2.512 nM
COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3cnn(C4CCNCC4)c3)n2)c1Cl CHEMBL5181852 IC50 2.53 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CC(=O)NC)c3)nc2c1 CHEMBL3935232 pIC50 2.57 nM
COc1cc(OC)cc(N(CCNC(=O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3912831 pIC50 2.57 nM
COc1cc(OC)cc(N(CCC2CCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3915268 pIC50 2.57 nM
COc1cc(OC)cc(N(CCN2CCN(C)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3905048 pIC50 2.57 nM
COc1cc(OC)c(F)c(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1F CHEMBL3903973 pIC50 2.57 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(NC(C)C)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4069509 IC50 2.61 nM
COc1cc(OC)cc(N(Cc2csc(C)n2)c2ccc3ncc(-c4cnn(CCN5CCNCC5)c4)nc3c2)c1 CHEMBL3921197 pIC50 2.63 nM
COc1cc(OC)cc(N(CCN2CCN(CCO)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3983529 pIC50 2.63 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3918751 pIC50 2.692 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(CCCN)c4)nc3c2)c1 CHEMBL3927875 pIC50 2.692 nM
COc1cc(OC)cc(N(Cc2csc(C)n2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3929914 pIC50 2.692 nM
COCCNc1ccc2c(Nc3cc(CCc4cc(OC)cc(OC)c4)[nH]n3)ncnc2c1 CHEMBL3798924 IC50 2.7 nM
COc1cc(C#Cc2nn(C3CN(C(=O)/C=C/CN(C)C(C)C)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701249 IC50 2.7 nM
COc1ccccc1Nc1ncc2c(n1)N(C1CCN(C(=O)/C=C/CN(C)C)CC1)C(=O)N(c1c(Cl)c(OC)cc(OC)c1Cl)C2 CHEMBL4077029 IC50 2.73 nM
COc1cc(OC)cc(N(CCN2CCC[C@@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3954671 pIC50 2.754 nM
COc1cc(OC)cc(N(C[C@H](O)CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3939764 pIC50 2.754 nM
COc1cc(OC)cc(N(CCCN2CCOC2=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3903198 pIC50 2.754 nM
COc1cc(OC)cc(N(CCN2CCC(C(C)(C)O)CC2)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3969112 pIC50 2.754 nM
COc1cc(F)cc(N(CCCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3951360 pIC50 2.754 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCCNC(C)C)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3925114 pIC50 2.754 nM
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(F)c(F)cc3O)cc12 CHEMBL4074407 IC50 2.8 nM
CNCC(O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3935264 pIC50 2.818 nM
CNCC(O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3932577 pIC50 2.818 nM
COc1cc(OC)cc(N(CC(O)CNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3978453 pIC50 2.818 nM
[2H]C([2H])([2H])Oc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3981418 pIC50 2.818 nM
COc1cc(OC)cc(N(CCCNC(=O)C(C)(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3935825 pIC50 2.818 nM
COc1cc(OC)cc(N(CCCNC(=O)C(C)(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3897101 pIC50 2.818 nM
COc1cc(OC)cc(N(CCCN2CCC(S(C)(=O)=O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3933707 pIC50 2.818 nM
COc1cc(OCCF)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3946674 pIC50 2.818 nM
COc1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3941700 pIC50 2.818 nM
COc1cc(OC)cc(N(CC(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3911635 pIC50 2.818 nM
COc1cc(OC)cc(N(Cc2cc(C)no2)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3951245 pIC50 2.884 nM
COc1cc(OC)cc(N(Cc2cc(C)on2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3979490 pIC50 2.884 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCCN4CCCC4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3972979 pIC50 2.884 nM
COc1cc(OC)cc(N(CCCN2CCCC2=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3973321 pIC50 2.884 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C(C)C)c3)nc2c1 CHEMBL3896052 pIC50 2.884 nM
COc1cc(OC)cc(N(CCN2CCC(CCO)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3973929 pIC50 2.884 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CCNCC5)c4)nc3c2)c1 CHEMBL3980069 pIC50 2.884 nM
COc1cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)cc2c1OCO2 CHEMBL3896142 pIC50 2.884 nM
COc1ccc(F)c(-c2ccc3c(NC(=O)c4ccc(N5CCN(C(C)=O)CC5)cc4)n[nH]c3c2)c1F CHEMBL4104460 IC50 2.9 nM
C=CC(=O)N1CCC(c2ccc(-c3nc(Nc4cc(C)[nH]n4)cc(N4CCN(C)CC4)n3)cc2)C1 CHEMBL4765110 GI50 2.9 nM
COc1cc(CCc2cc(-c3nc4ccccc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5207581 IC50 2.91 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC5CCNCC5)c4)nc3c2)c1 CHEMBL3976280 pIC50 2.951 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC5(O)CCNCC5)c4)nc3c2)c1 CHEMBL3911573 pIC50 2.951 nM
COc1cc(OC)cc(N(CC(O)CN2CCCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3969475 pIC50 2.951 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCCO)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3954298 pIC50 2.951 nM
COc1cc(F)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3950069 pIC50 2.951 nM
COc1cc(OC)cc(N(CCCNC(=O)C(F)(F)F)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3983918 pIC50 2.951 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CCN(C)CC5)c4)nc3c2)c1 CHEMBL3917908 pIC50 2.951 nM
COc1cc(OC)cc(N(CC#Cc2cc(N)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3902961 pIC50 2.951 nM
COc1cc(OC)cc(N(C[C@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(CCCN)c4)nc3c2)c1 CHEMBL3950510 pIC50 2.951 nM
COc1cc(OC)c(F)c(N(CCCNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1F CHEMBL3892529 pIC50 2.951 nM
CCN(C)C/C=C/C(=O)N1CC(n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701245 IC50 3.0 nM
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3ccccc3O)cc12 CHEMBL4073545 IC50 3.0 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC(O)CN5CCCCC5)c4)nc3c2)c1 CHEMBL3964675 pIC50 3.02 nM
COc1cc(OC)cc(N(CC2CCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3926406 pIC50 3.02 nM
COc1cc(OC)cc(N(Cc2csc(C)n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3961872 pIC50 3.02 nM
COc1cc(OC)cc(N(CCN2CCC(N)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3893718 pIC50 3.02 nM
CCN(CC)CCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3916975 pIC50 3.02 nM
COc1cc(OC)cc(N(CCNCC2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3935457 pIC50 3.02 nM
NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)NCCCCN1CCCC1 CHEMBL253969 IC50 3.08 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3961210 pIC50 3.09 nM
COc1cc(OC)cc(N(Cc2nnc(N)o2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3968009 pIC50 3.09 nM
COc1cc(OC)cc(N(CCN2CCC(CO)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3917141 pIC50 3.09 nM
COc1cc(OC)cc(N(CCCN2CCCC2=O)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3904294 pIC50 3.09 nM
COc1cc(OC)cc(N(CCNC2CCN(S(N)(=O)=O)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3917295 pIC50 3.09 nM
COc1cc(OC)cc(N(CCCN2CCC[C@H]2CC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921476 pIC50 3.09 nM
COc1cccnc1C#CCN(c1ccc2ncc(-c3cnn(C)c3)nc2c1)c1c(F)c(OC)cc(OC)c1F CHEMBL3976275 pIC50 3.09 nM
COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3ccc(N4CCOCC4)nc3)n2)c1Cl CHEMBL5206623 IC50 3.09 nM
CCNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)ncc1NC(=O)c1cc(OC)cc(OC)c1 CHEMBL4642080 IC50 3.1 nM
C=CC(=O)N1CCC(c2cc3c(Oc4ccc(NC(=O)NC5CC5)c(Cl)c4)ccnc3cc2OC)CC1 CHEMBL5439595 IC50 3.1 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCN5CCNCC5)c4)nc3c2)c1 CHEMBL3985853 pIC50 3.162 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC5CCN(C)CC5)c4)nc3c2)c1 CHEMBL3948321 pIC50 3.162 nM
COc1cc(OC)cc(N(C[C@@H]2CCCN2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3979170 pIC50 3.162 nM
COc1cc(OC)cc(N(Cc2ccco2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3975954 pIC50 3.162 nM
COc1cc(OC)c(Cl)c(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3892135 pIC50 3.162 nM
[2H]C([2H])([2H])Oc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3975791 pIC50 3.162 nM
COc1cc(OC)cc(N(Cc2ccc(Cl)nc2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907642 pIC50 3.162 nM
CNC(=O)c1cc(F)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3901612 pIC50 3.162 nM
COc1cc(CCc2cc(Nc3ncnc4ccccc34)n[nH]2)cc(OC)c1 CHEMBL3797268 IC50 3.2 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(OCCN6CCOCC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3676315 IC50 3.2 nM
COc1cc(C#Cc2cn([C@H]3CCN(C(=O)/C=C/CN4CCCC4)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701259 IC50 3.2 nM
COc1cc(OC)cc(N(CCC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3951126 pIC50 3.236 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3898881 pIC50 3.236 nM
COc1cc(OC)cc(N(CCNC2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3923296 pIC50 3.236 nM
COc1cc(OC)cc(N(CC(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3900574 pIC50 3.236 nM
COc1cc(OC)cc(N(CCCN2[C@H](C)CC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3927451 pIC50 3.236 nM
COc1cc(C#Cc2nn(C3CN(C(=O)/C=C/CN4CCCCC4)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701250 IC50 3.3 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3892018 pIC50 3.311 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCO)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3909565 pIC50 3.311 nM
COc1cc(OC)cc(N(CCN2CCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3890607 pIC50 3.311 nM
COc1cc(OC)cc(N(Cc2ccc(Cl)s2)c2ccc3ncc(-c4cnn(CCN5CCNCC5)c4)nc3c2)c1 CHEMBL3904441 pIC50 3.311 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4CO)nc3c2)c1 CHEMBL3932022 pIC50 3.311 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3898355 pIC50 3.388 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3893008 pIC50 3.388 nM
CCOC(=O)C1CCN(CCN(c2cc(OC)cc(OC)c2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)CC1 CHEMBL3904745 pIC50 3.388 nM
COc1cc(Cl)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3965614 pIC50 3.388 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCNC(C)C)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3909551 pIC50 3.388 nM
COc1cc(OC)cc(N(CCN2CCC(N(C)C)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3958708 pIC50 3.388 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3940175 pIC50 3.388 nM
COc1cc(OC)cc(N(CCN2CC3(COC3)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3934487 pIC50 3.388 nM
COc1cc(OC)cc(N(C[C@@H](O)CN2CC[C@H](C#N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3967065 pIC50 3.388 nM
COc1cc(OC)cc(N(CC2COCC(C)(C)N2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3901119 pIC50 3.388 nM
COc1cc(OC)cc(N(CCCNC(C)(C)CF)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921469 pIC50 3.388 nM
CCc1c(-c2cnc3ccc(N(CCNC(C)C)c4cc(OC)cc(OC)c4)cc3n2)cnn1C CHEMBL3918426 pIC50 3.388 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C([2H])([2H])C([2H])([2H])C([2H])([2H])O)c1 CHEMBL3906284 pIC50 3.388 nM
COc1ccnc(C#CCN(c2ccc3ncc(-c4cnn(C)c4)nc3c2)c2c(F)c(OC)cc(OC)c2F)n1 CHEMBL3978754 pIC50 3.388 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(CN6CCOCC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681278 IC50 3.4 nM
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(F)cc(F)c3O)cc12 CHEMBL4077448 IC50 3.4 nM
COc1cc(OC)cc(N(Cc2cc(C)no2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3898908 pIC50 3.467 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3949470 pIC50 3.467 nM
COc1cc(OC)cc(N(CCCN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3937633 pIC50 3.467 nM
[2H]C([2H])([2H])n1cc(-c2ccc3ncc(N(CCO)c4cc(OC)cc(OC)c4)nc3c2)cn1 CHEMBL3959849 pIC50 3.467 nM
COc1cc(OC)c(Cl)c(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3922586 pIC50 3.467 nM
CNC(=O)c1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3927733 pIC50 3.467 nM
COc1cc(OC)c(Cl)c(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3986068 pIC50 3.467 nM
COC[C@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C(C)C)c3)nc2c1 CHEMBL3926556 pIC50 3.467 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCC5CCNCC5)c4)nc3c2)c1 CHEMBL3925306 pIC50 3.548 nM
COc1cc(OCCO)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3909318 pIC50 3.548 nM
COc1cc(OC)cc(N(CCNC(=O)C2CCCN(C)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3979885 pIC50 3.548 nM
COc1cc(OC)cc(N(CCCNC(=O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3891892 pIC50 3.548 nM
COc1cc(OC)c(C)c(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3945264 pIC50 3.548 nM
CCn1cc(-c2cnc3ccc(N(CCNC)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3893344 pIC50 3.548 nM
COc1cc(OC)cc(N(CCCN2C[C@@H](C)O[C@@H](C)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3914955 pIC50 3.548 nM
COc1cc(OC)cc(N(CCC(C)(C)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3950910 pIC50 3.548 nM
COc1cc(OC)c(F)c(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1F CHEMBL3954396 pIC50 3.548 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5c([nH]4)=CC(CN4CCOCC4)C(F)C=5)c3N)ccc2[nH]1 CHEMBL3681294 IC50 3.6 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCOC4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4096738 IC50 3.63 nM
COCCn1cc(-c2cnc3ccc(N(Cc4cc(C)no4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3985692 pIC50 3.631 nM
COC[C@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CCCN)c3)nc2c1 CHEMBL3916200 pIC50 3.631 nM
C=CC(=O)N1CC(n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C[C@H]1CO CHEMBL3701254 IC50 3.7 nM
COc1ccc(Cl)c(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3969824 pIC50 3.715 nM
COc1cc(OC)cc(N(CCNC(=O)C(C)(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3899692 pIC50 3.715 nM
COc1cc(OC)cc(N(C[C@H](O)CN2CC[C@H](C#N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3980252 pIC50 3.715 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(CCCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921441 pIC50 3.715 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CCN(C(=O)OC(C)(C)C)CC5)c4)nc3c2)c1 CHEMBL3896249 pIC50 3.715 nM
COc1cc(OC)cc(N(CC#CC2(O)CNC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3922100 pIC50 3.715 nM
COc1cc(C#Cc2nn(C3CN(C(=O)/C=C/CNC(C)C)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701244 IC50 3.8 nM
COc1cc(C#Cc2nn(C3CN(C(=O)/C=C/CNC4CCC4)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701246 IC50 3.8 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C5CCNCC5)c4)nc3c2)c1 CHEMBL3969446 pIC50 3.802 nM
COc1cc(OC)cc(N(CC(O)CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3943387 pIC50 3.802 nM
COc1cc(OC)c(C)c(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3932285 pIC50 3.802 nM
COc1cc(OC)cc(N(C[C@H](O)CNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3975397 pIC50 3.802 nM
COc1cc(OC)cc(N(CCN2[C@@H](C)CC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3932756 pIC50 3.802 nM
COc1cc(OC)cc(N(CCCNCC(C)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3966200 pIC50 3.802 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3958153 pIC50 3.89 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C5CN(CCO)C5)c4)nc3c2)c1 CHEMBL3906122 pIC50 3.89 nM
COc1cc(OC)cc(N(CCCCN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3969373 pIC50 3.89 nM
COc1cc(OC)cc(N(CCN2CCC(C(C)(C)O)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3931154 pIC50 3.89 nM
COc1cc(OC)cc(N(CCn2cccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3933341 pIC50 3.89 nM
COc1cc(O)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3962492 pIC50 3.89 nM
COc1cc(OC)cc(N(CCN(C)C(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3908707 pIC50 3.89 nM
COc1cc(CCc2cc(Nc3ncnc4c(OC)cccc34)n[nH]2)cc(OC)c1 CHEMBL3797238 IC50 3.9 nM
COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3cnn(CCCN(C)C)c3)n2)c1Cl CHEMBL5200941 IC50 3.96 nM
COc1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3987037 pIC50 3.981 nM
COc1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3908877 pIC50 3.981 nM
CNC(=O)Cn1cc(-c2ccc3ncc(N(CCN)c4cc(OC)cc(OC)c4)nc3c2)cn1 CHEMBL3976053 pIC50 3.981 nM
COc1cc(OC)cc(N(Cc2cn(CCO)nn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921457 pIC50 3.981 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3947189 pIC50 3.981 nM
CNC(=O)c1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907063 pIC50 3.981 nM
COc1cc(OC)cc(N(C[C@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3916037 pIC50 3.981 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(N6CCOCC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681284 IC50 4.0 nM
COc1cc2[nH]c(C(=O)c3cnn(-c4ccc5[nH]c(C)nc5c4)c3N)cc2cc1Cl CHEMBL3681303 IC50 4.0 nM
C=CC(=O)Nc1ccc(CN2C(=O)N(c3cc(OC)cc(OC)c3)Cc3cnc(Nc4ccc(N5CCN(C)CC5)cc4)nc32)cc1 CHEMBL4065323 IC50 4.0 nM
CCN1CCN(c2ccc(C(=O)Nc3n[nH]c4cc(-c5cccc(OC)c5F)ccc34)cc2)CC1 CHEMBL4076610 IC50 4.0 nM
C=CC(=O)N1CC(c2ccc(-c3nc(Nc4cc(C)[nH]n4)cc(N4CCN(C)CC4)n3)cc2)C1 CHEMBL4746615 GI50 4.0 nM
CCNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3939278 pIC50 4.074 nM
COc1cc(OC)cc(N(CCN2CCC[C@H]2C(=O)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3959201 pIC50 4.074 nM
COc1cc(OC)cc(N(C[C@@H](O)CNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3891966 pIC50 4.074 nM
CCN(CC)C/C=C/C(=O)N1CC(n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701247 IC50 4.1 nM
COc1cc(OC)cc(N(CC#CC(C)(C)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3924172 pIC50 4.169 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCN5CCN(CCCO)CC5)c4)nc3c2)c1 CHEMBL3951171 pIC50 4.169 nM
CNC(=O)c1cc(OC)cc(N(CC(O)CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3910555 pIC50 4.169 nM
Nc1c(C(=O)c2cc3cc(CN4CCOCC4)ccc3[nH]2)cnn1-c1cc(O)ccc1Cl CHEMBL3984621 IC50 4.2 nM
COc1cc(OC)cc(N(CCCN2CCC(OC)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3972517 pIC50 4.266 nM
[2H]C([2H])([2H])Oc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3925081 pIC50 4.266 nM
COc1cc(OC)cc(N(CC2COCCN2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3919884 pIC50 4.266 nM
COc1cc(O)cc(N(CCCO)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3897155 pIC50 4.266 nM
COc1cc(OC)cc(N(CCC(=O)N(C)OC)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3956493 pIC50 4.266 nM
CCN1CCN(c2cccc3c(Nc4cc(CCc5cc(OC)cc(OC)c5)[nH]n4)ncnc23)CC1 CHEMBL3798127 IC50 4.3 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(OC6CCOCC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3676316 IC50 4.3 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(CN6CCOC[C@@H]6C)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3676328 IC50 4.3 nM
COc1cc(C#Cc2nn(C3CN(C(=O)/C=C/CNC(C)(C)C)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701248 IC50 4.3 nM
CC#CC(=O)N1CC[C@H](n2cc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701261 IC50 4.3 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCN5CCN(CCO)CC5)c4)nc3c2)c1 CHEMBL3937533 pIC50 4.365 nM
COc1cc(OCCO)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3974693 pIC50 4.365 nM
COCC(O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3942594 pIC50 4.365 nM
COc1cc(OC)cc(N(CC2(OC)CCCNC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3891474 pIC50 4.365 nM
COc1cc(OC)cc(N(CC2CCN(C)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3893070 pIC50 4.365 nM
COc1cc(OC)cc(N(CCCN2CCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3973263 pIC50 4.365 nM
COc1cc(OC)cc(N(CCNCC2CCCO2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3896623 pIC50 4.365 nM
COc1cc(OC)cc(N(CCN2CCCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3982107 pIC50 4.365 nM
COc1cc(OC)cc(N(CC(C)NC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3945277 pIC50 4.365 nM
COc1cc(OC)cc(N(CCCNCC(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3934080 pIC50 4.365 nM
COc1cc(OC)cc(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1 CHEMBL4856613 IC50 4.4 nM
C=CC(=O)N1CCC(n2nc3c(=O)[nH]nc(N)c3c2-c2oc3ccc(C)cc3c2C)CC1 CHEMBL5290648 IC50 4.4 nM
COc1cc(OC)cc(N(CCC(=O)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3944224 pIC50 4.467 nM
COc1cc(OC)cc(N(C[C@@H]2C[C@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3913970 pIC50 4.467 nM
COc1cc(F)cc(N(CCCN2CCC(C#N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3942811 pIC50 4.467 nM
COc1cc(OC)cc(N(CCCn2c(C)cnc2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3911746 pIC50 4.467 nM
COc1cc(OC)cc(N(CC#Cc2cc(N)nc(C)n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3982399 pIC50 4.467 nM
COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)c1Cl CHEMBL5185122 IC50 4.49 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(N5CCN(C)CC5)cc4)c3)ccc12 CHEMBL4290371 IC50 4.5 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CCS(C)(=O)=O)c3)nc2c1 CHEMBL3984548 pIC50 4.571 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(C5CCCCO5)c4)nc3c2)c1 CHEMBL3980232 pIC50 4.571 nM
COc1cc(OC)cc(N(CCCN2CCC(N3C[C@@H](C)O[C@@H](C)C3)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3961400 pIC50 4.571 nM
CNCCN(c1cc(F)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3891464 pIC50 4.571 nM
COc1cc(OC)cc(N(CCNCCF)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3960571 pIC50 4.571 nM
COc1cc(OC)cc(N(CC#Cc2cc(CO)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3980417 pIC50 4.571 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5cc(CN6CCCC6)ccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681292 IC50 4.6 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3901627 pIC50 4.677 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC(=O)NCCO)c4)nc3c2)c1 CHEMBL3985750 pIC50 4.677 nM
COc1cc(OC)cc(N(CCNC(C)=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3945373 pIC50 4.677 nM
COc1cc(OC)cc(N(CCNCCC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3951847 pIC50 4.677 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4C)nc3c2)c1 CHEMBL3966071 pIC50 4.677 nM
COc1cc(OC)cc(N(CCP(=O)(O)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3950169 pIC50 4.677 nM
COc1cc(C#CC2=CC([C@H]3CCN(C(=O)/C=C/CN(C)C)C3)c3ncnc(N)c32)cc(OC)c1 CHEMBL3701257 IC50 4.7 nM
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3ccc(F)cc3O)cc12 CHEMBL4075917 IC50 4.7 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCCN)c4)nc3c2)c1 CHEMBL3898120 pIC50 4.786 nM
COc1ccc(Cl)c(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3983387 pIC50 4.786 nM
COc1cc(OC)cc(N(CCNC(=O)C2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3963323 pIC50 4.786 nM
COc1cc(OC)cc(N(CCNC[Si](C)(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3893950 pIC50 4.786 nM
COc1cc(CCc2cc(Nc3ncnc4c(Cl)cccc34)n[nH]2)cc(OC)c1 CHEMBL3799140 IC50 4.8 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5cc(CN6CCN(C)CC6)ccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681291 IC50 4.8 nM
CNC(=O)c1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(CCOC)c4)nc3c2)c1 CHEMBL3908529 pIC50 4.898 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC(=O)N5CCC(O)C5)c4)nc3c2)c1 CHEMBL3929803 pIC50 4.898 nM
COc1cc(OC)cc(N(CC(O)CN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3936828 pIC50 4.898 nM
COc1cc(OC)cc(N(CCN2CC[C@H](C#N)C2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3898568 pIC50 4.898 nM
COc1cc(OC)cc(N(CCN2CCNC(=O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3934355 pIC50 4.898 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C(C)CNC(C)C)c1 CHEMBL3942606 pIC50 4.898 nM
CCN(CC)CCCCNc1ncc2cc(-c3cc(OC)cc(OC)c3)c(NC(=O)NC(C)(C)C)nc2n1 CHEMBL189584 IC50 5.0 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cn[nH]c3)nc2c1 CHEMBL3920908 pIC50 5.012 nM
COc1cc(OC)cc(N(CCNC2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3918495 pIC50 5.012 nM
CNC(=O)c1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3965640 pIC50 5.012 nM
CNC(=O)c1cc(F)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3918704 pIC50 5.012 nM
COCC(O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C(C)C)c3)nc2c1 CHEMBL3984461 pIC50 5.012 nM
COCC(O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C(C)C)c3)nc2c1 CHEMBL3981955 pIC50 5.012 nM
COc1cc(OC)cc(N(CCN(CCCN)C(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3902434 pIC50 5.012 nM
CCNS(=O)(=O)c1ccccc1Nc1ncnc(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)n1 CHEMBL4641667 IC50 5.1 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCCNCCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3973820 pIC50 5.129 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCN5CCCC5)c4)nc3c2)c1 CHEMBL3962814 pIC50 5.129 nM
COc1cc(OC)cc(N(CCN2CCC(N(C)C)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3962554 pIC50 5.129 nM
COc1cc(OC)cc(N(Cc2cn[nH]n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3904561 pIC50 5.129 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C2COC2)c1 CHEMBL3985259 pIC50 5.129 nM
CNC(=O)c1cc(F)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3946103 pIC50 5.129 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCN5CCN(CCO)CC5)c4)nc3c2)c1 CHEMBL3957473 pIC50 5.129 nM
Cc1nc2ccc(-n3ncc(C(=O)c4cc5cc(CN6CCOCC6)ccc5[nH]4)c3N)cc2[nH]1 CHEMBL3891894 IC50 5.2 nM
CN1CC2CCC(C1=O)C2c1ncc2[nH]nc(-c3cnn(C)c3)c2n1 CHEMBL5290074 IC50 5.2 nM
C=CC(=O)N1CCC(c2cc3c(Oc4ccc(NC(=O)NC5CC5)c(Cl)c4)ccnc3cc2OCC)CC1 CHEMBL5436527 IC50 5.2 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC(=O)NCCN5CCCC5)c4)nc3c2)c1 CHEMBL3951714 pIC50 5.248 nM
COc1cc(OC)cc(N(CCN2CC[C@H](C#N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3960327 pIC50 5.248 nM
COc1cc(OC)cc(N(CC(O)CNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907047 pIC50 5.248 nM
COc1cc(OC)cc(N(CC(O)CN2CCOCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3966560 pIC50 5.248 nM
COc1cc(F)cc(N(CCCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3902110 pIC50 5.248 nM
COc1cc(O)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3893642 pIC50 5.248 nM
COc1cc(OC)cc(N(CCS(C)(=O)=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3942716 pIC50 5.248 nM
COC[C@@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C(C)C)c3)nc2c1 CHEMBL3965482 pIC50 5.37 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5cc(C(=O)N6CCCC(F)(F)C6)ccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3676320 IC50 5.4 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC5(OC)CCNCC5)c4)nc3c2)c1 CHEMBL3908326 pIC50 5.495 nM
COc1cc(OC)cc(N(CCN2C(C)CCCC2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3920007 pIC50 5.495 nM
COc1cc(OC)cc(N(CCCn2ccnc2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3969665 pIC50 5.495 nM
COc1cc(OC)cc(N(CC#Cc2ccnc(N)n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3964043 pIC50 5.495 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(CN6CCC(O)CC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3676313 IC50 5.5 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(-c6ccc(F)cn6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681250 IC50 5.5 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5c(C(C)(C)C)cc(C(C)(C)C)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681307 IC50 5.5 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(CN6CCNCC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3676314 IC50 5.6 nM
COc1cc(C#Cc2nn(C3CN(C(=O)/C=C/CN4CC[C@H](F)C4)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701251 IC50 5.6 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C([2H])([2H])C([2H])([2H])O)c1 CHEMBL3946938 pIC50 5.623 nM
COc1cc(OC)cc(N(CCC(=O)NC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3947664 pIC50 5.623 nM
COc1cc(OC)cc(N(CCCNCC(F)(F)F)c2ccc3ncc(-c4cnn(CCCN)c4)nc3c2)c1 CHEMBL3892155 pIC50 5.754 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCN)c4)nc3c2)c1 CHEMBL3921817 pIC50 5.754 nM
COc1cc(OC)cc(N(CC#CC2CCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3986861 pIC50 5.754 nM
COc1cc(OC)cc(N(Cc2cc3ncccc3[nH]2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3939860 pIC50 5.754 nM
COc1cc(C#Cc2cn([C@H]3CCN(C(=O)/C=C/CN4CCCCC4)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701265 IC50 5.8 nM
COc1cc(OC)cc(N(CCN2CCOCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3982668 pIC50 5.888 nM
COc1cc(OC)cc(N(CCN(Cc2ccc(N)cc2)C(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3950496 pIC50 5.888 nM
COc1cc(OC)cc(N(C[C@@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3905276 pIC50 5.888 nM
COc1cc(OC)cc(N(CC#Cc2cc(C(N)=O)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921190 pIC50 5.888 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5c(NC(CO)CO)cccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681282 IC50 6.0 nM
COC/C(CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1)=N/O CHEMBL3892632 pIC50 6.026 nM
COc1cc(OC)cc(N(CCCN2CCS(=O)(=O)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3925077 pIC50 6.026 nM
COc1cc(OC)cc(N(CCN2C[C@@H]3C[C@H]2CN3)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3940672 pIC50 6.026 nM
COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3ccc(N4CCC(O)CC4)cc3)n2)c1Cl CHEMBL5190994 IC50 6.05 nM
C#CCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3900620 pIC50 6.166 nM
COc1cc(OC)cc(N(CCN2CCN(C(C)=O)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3981076 pIC50 6.166 nM
COc1cc(OC)cc(N(Cc2nccn2S(=O)(=O)N(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3889711 pIC50 6.166 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)[C@H](C)CN)c1 CHEMBL3957414 pIC50 6.166 nM
Cc1nc2cc(-n3ncc(C(=O)C4=CC5C=CC(C#N)=CC5N4)c3N)ccc2[nH]1 CHEMBL3681264 IC50 6.2 nM
CC(=O)N1CCN(Cc2ccc3cc(C(=O)c4cnn(-c5ccc6[nH]c(C)nc6c5)c4N)[nH]c3c2)CC1 CHEMBL3681290 IC50 6.3 nM
COc1cc(OC)cc(N(CCCNCC(F)(F)F)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3911738 pIC50 6.31 nM
COc1cc(OC)cc(N(CCN(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3952277 pIC50 6.31 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C5CCNCC5)c4)nc3c2)c1 CHEMBL3897783 pIC50 6.31 nM
COc1cccc(Nc2ncnc(-c3cccnc3Nc3c(Cl)c(OC)cc(OC)c3Cl)n2)c1 CHEMBL5188557 IC50 6.36 nM
CCOC(=O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3921313 pIC50 6.457 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCCN5CCN(CCCO)CC5)c4)nc3c2)c1 CHEMBL3908829 pIC50 6.457 nM
COCCNC(=O)Cn1cc(-c2cnc3ccc(N(CC4CC4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3983115 pIC50 6.457 nM
COc1cc(OC)cc(N(CC2CO2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3974664 pIC50 6.457 nM
CNC(=O)c1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3929648 pIC50 6.457 nM
COc1cc(OC)cc(N(CCN2CCCC(N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3957533 pIC50 6.457 nM
COc1cc(OC)c(C)c(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3947361 pIC50 6.457 nM
COc1cc(OC)cc(N(C[C@@H](O)CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3967739 pIC50 6.457 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CC4CCOCC4)c3)nc2c1 CHEMBL3932363 pIC50 6.457 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C5CCN(C)CC5)c4)nc3c2)c1 CHEMBL3967761 pIC50 6.457 nM
COc1cc(C#Cc2cn([C@H]3CCN(C(=O)/C=C/CN4CCC(O)CC4)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701260 IC50 6.6 nM
Cc1n[nH]c2ncc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(Cl)ccc3O)cc12 CHEMBL4082721 IC50 6.6 nM
C=CC(=O)NCc1ccc(-n2nc3c(=O)[nH]nc(N)c3c2-c2oc3ccc(C)cc3c2C)cc1 CHEMBL4541330 IC50 6.6 nM
COc1cc(OC)cc(N(CC(C)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3904329 pIC50 6.607 nM
COc1cc(OC)c(Cl)c(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1Cl CHEMBL3978617 pIC50 6.607 nM
COc1cc(OC)cc(N(CCF)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3891525 pIC50 6.607 nM
CNC(=O)OCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3973531 pIC50 6.761 nM
COc1cc(C#Cc2nn(C3CN(C(=O)/C=C/CN4CC[C@@H](F)C4)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701252 IC50 6.8 nM
COc1cc(C#Cc2cn([C@H]3CCN(C(=O)/C=C/CN4CC[C@@H](F)C4)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701263 IC50 6.8 nM
C=CC(=O)N1CC[C@H](n2nc(C#Cc3cc(OCC)cc(OCC)c3)c3c(N)ncnc32)C1 CHEMBL3701240 IC50 6.9 nM
COc1cc(OC)cc(N(C/C(C)=N\O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3948270 pIC50 6.918 nM
CNC(=O)c1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3912310 pIC50 6.918 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cn(C)nc4C(F)(F)F)nc3c2)c1 CHEMBL3948234 pIC50 6.918 nM
COc1cc(C#Cc2cn([C@H]3CCN(C(=O)/C=C/CN4CC[C@H](F)C4)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701264 IC50 7.0 nM
COc1cc(C#Cc2cn(C3CCN(C(=O)/C=C/CN(C)C)CC3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701277 IC50 7.0 nM
COc1ccc(F)c(-c2ccc3c(NC(=O)c4ccc(N5C[C@@H](C)N[C@@H](C)C5)cc4)n[nH]c3c2)c1F CHEMBL4081153 IC50 7.0 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC(=O)N(C)C)c4)nc3c2)c1 CHEMBL3925254 pIC50 7.079 nM
CNC(=O)c1cc(F)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3944438 pIC50 7.079 nM
[2H]C([2H])([2H])Oc1cc(F)cc(N(CCN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3955745 pIC50 7.079 nM
COc1cc(OC)cc(N(CC#CC2(O)CCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3984035 pIC50 7.079 nM
COc1cc(OC)cc(N(CC#Cc2cc(OC)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3927140 pIC50 7.079 nM
C=CC(=O)N1CC(n2nc(C#Cc3cc(OCC)cc(OCC)c3)c3c(N)ncnc32)C1 CHEMBL3701253 IC50 7.2 nM
Cc1c(-c2c3c(N)n[nH]c(=O)c3nn2-c2ccc(NC(=O)/C=C/CN(C)C)cc2)oc2ccc(Cl)cc12 CHEMBL4462946 IC50 7.2 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCCN5CCOCC5)c4)nc3c2)c1 CHEMBL3927327 pIC50 7.244 nM
COc1cc(OC)cc(N(CCCN2CCC(F)(F)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3950907 pIC50 7.244 nM
COc1cc(OC)cc(N(C/C(=N\O)C(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3982351 pIC50 7.244 nM
COc1cccc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3933442 pIC50 7.244 nM
COc1cc(OC)cc(N(CCCc2ccncc2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3920637 pIC50 7.244 nM
COc1cc(OC)cc(N(CC#CC2(O)CCNC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3941227 pIC50 7.244 nM
COC[C@@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CCCN)c3)nc2c1 CHEMBL3942506 pIC50 7.244 nM
COc1cc(OC)cc(N(C/C(C)=N/O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3955817 pIC50 7.413 nM
COc1cc(OC)cc(N(CCc2nnn[nH]2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3905212 pIC50 7.413 nM
CNC(=O)c1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3901420 pIC50 7.413 nM
COc1cc(OC)cc(N(C[C@H](C)N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3895378 pIC50 7.413 nM
COc1cc(OC)cc(N(CC#Cc2nccc(OC)n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3953833 pIC50 7.413 nM
COc1cc(OC)cc(N(CC2CN(Cc3ccccc3)CCO2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3925610 pIC50 7.586 nM
COc1cc(OC)cc(N(Cc2cc(C)n(C)n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3953117 pIC50 7.586 nM
COc1cc(OC)cc(N(C[C@@H](C)N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3898346 pIC50 7.586 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)[C@@H](C)CN)c1 CHEMBL3922607 pIC50 7.586 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C5CCN(C(=O)OC(C)(C)C)CC5)c4)nc3c2)c1 CHEMBL3977010 pIC50 7.586 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C([2H])([2H])C([2H])([2H])C([2H])([2H])NCC(F)(F)F)c1 CHEMBL3966929 pIC50 7.586 nM
Cc1nc2ccc(-n3ncc(C(=O)c4cc5ccccc5[nH]4)c3N)cc2[nH]1 CHEMBL3907479 IC50 7.6 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5cc6c(cc5[nH]4)OCCO6)c3N)ccc2[nH]1 CHEMBL3681306 IC50 7.6 nM
CCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3931533 pIC50 7.762 nM
COc1cc(OC)cc(N(CCN2CCN(C(=O)C3CC3)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3972617 pIC50 7.762 nM
COc1cc(OC)cc(N(C[C@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3969414 pIC50 7.762 nM
C#CCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CC4CCOCC4)c3)nc2c1 CHEMBL3939018 pIC50 7.762 nM
C=CC(=O)N1CCC(n2cc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)CC1 CHEMBL3701276 IC50 7.9 nM
COc1cc(CO)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3919750 pIC50 7.943 nM
Cc1ccc2oc(-c3c4c(N)n[nH]c(=O)c4nn3-c3ccc(NC(=O)/C=C/CN4CCOCC4)cc3)c(C)c2c1 CHEMBL4447110 IC50 8.0 nM
COC(=O)Nc1ccc(-c2c(OC3CCN(C)CC3)nc3c(-c4ccc(OC)c(OC)c4)cnn3c2N)cc1 CHEMBL4634073 IC50 8.0 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3955288 pIC50 8.128 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CC4CC4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3907600 pIC50 8.128 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C(C)(C)C(=O)NCCO)c4)nc3c2)c1 CHEMBL3976219 pIC50 8.128 nM
COc1cc(OC)cc(N(CC#Cc2ccncc2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3897523 pIC50 8.128 nM
COc1cc(OC)cc(N(CCNCCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3895443 pIC50 8.128 nM
COc1cc(OC)cc(N(Cc2ncccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3901265 pIC50 8.128 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5cc(OCC6CC6)ccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681248 IC50 8.3 nM
COCCNC(=O)C(C)(C)n1cc(-c2cnc3ccc(N(CC4CC4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3962805 pIC50 8.318 nM
COc1cc(OC)cc(N(Cc2cccs2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3911516 pIC50 8.318 nM
COc1cc(OC)cc(N(Cc2cccc(Br)n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3940940 pIC50 8.318 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(C6CCN(C)CC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681270 IC50 8.4 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5cc(F)c(Br)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3676317 IC50 8.5 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5cc(CN6CCCC(F)C6)ccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681272 IC50 8.5 nM
COc1cc(CCc2cc(-c3nc4ccc(-c5ccc(N6CCOCC6)nc5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5209158 IC50 8.5 nM
CNC(=O)C(C)(C)n1cc(-c2cnc3ccc(N(CC4CC4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3948623 pIC50 8.511 nM
COc1cc(OC)cc(N(CCNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3950156 pIC50 8.511 nM
COc1cc(OC)cc(N(CC#Cc2ccncc2C#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3979972 pIC50 8.511 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(I)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3676331 IC50 8.6 nM
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(Cl)ccc3O)cc12 CHEMBL4105329 IC50 8.6 nM
COc1cc(OC)cc(N(CC2CCOCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3956120 pIC50 8.71 nM
COc1cc(OC)cc(N(CCCN2CCC(F)(F)C2)c2ccc3ncc(-c4cnn(CC5CCOCC5)c4)nc3c2)c1 CHEMBL3924422 pIC50 8.71 nM
C=CC(=O)N1C[C@@H](n2cc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C[C@H]1c1nnc(C)o1 CHEMBL3701280 IC50 8.8 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(Br)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3676329 IC50 8.9 nM
COc1cc(OC)cc(N(CC2OCCO2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3901644 pIC50 8.913 nM
COc1cc(F)cc(N(CCCO)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3897034 pIC50 8.913 nM
COc1cc(OC)cc(N(Cc2ccc(Cl)s2)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3986661 pIC50 8.913 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5cc(C(=O)N6CCOCC6)ccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681285 IC50 9.1 nM
COc1cc(OCCF)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3959193 pIC50 9.12 nM
COc1cc(OC)c(Cl)c(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1Cl CHEMBL3979328 pIC50 9.12 nM
C=CC(=O)N1CC(Cn2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701255 IC50 9.3 nM
CCOCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3906155 pIC50 9.333 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C(C)CNCC(F)(F)F)c1 CHEMBL3890852 pIC50 9.333 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(CN6CCC(F)(F)CC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681314 IC50 9.4 nM
CCN1CCN(c2ccc(C(=O)Nc3n[nH]c4cc(-c5cccc(OC)c5F)c(F)cc34)cc2)CC1 CHEMBL4079317 IC50 9.5 nM
CNC(=O)c1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCOC)c4)nc3c2)c1 CHEMBL3931674 pIC50 9.55 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(CC#Cc2ccncc2)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3943917 pIC50 9.55 nM
CCOc1ccnc(C#CCN(c2cc(OC)cc(OC)c2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)n1 CHEMBL3894754 pIC50 9.55 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCN)c4)nc3c2)c1 CHEMBL3956164 pIC50 9.772 nM
COc1cc(OCCO)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3891619 pIC50 9.772 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(CCCNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3927219 pIC50 9.772 nM
COc1cc(OC)cc(N(CC#Cc2ncccc2N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3906938 pIC50 9.772 nM