C=CC(=O)N1CC(N2C=C(C#Cc3cc(OC)cc(OC)c3)C3C(N)=NC=NC32)C1 CHEMBL3701266 IC50 0.1 nM
C=CC(=O)Nc1ccc(/C=C/c2nc(Nc3cc(C(C)C)[nH]n3)cc(N3CCN(C)CC3)n2)cc1 CHEMBL4776177 GI50 0.1 nM
C#CC(=O)N1CC[C@H](n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701239 IC50 0.2 nM
COc1cc(C)cc2cc(-c3c(CN4CCNC(=O)C4)c(Cl)n4ncnc(N)c34)sc12 CHEMBL3937124 IC50 0.2 nM
C=CC(=O)Nc1ccc(/C=C/c2nc(Nc3cc(CC)[nH]n3)cc(N3CCN(C)CC3)n2)cc1 CHEMBL4748389 GI50 0.2 nM
[2H]C([2H])([2H])NC(=O)c1cncc(-c2cnn3cc(-c4ccn(C(C)C)n4)c(N[C@H]4CCOC4)nc23)c1 CHEMBL5175256 IC50 0.2 nM
C[C@H](Nc1c(-c2nc3cnc(N4CCOCC4)cc3[nH]2)c(=O)[nH]c2cn(C)nc12)c1ncccn1 CHEMBL4577380 IC50 0.212 nM
CC[C@H](Nc1c(-c2nc3cc(C)c(N4CCOCC4)cc3[nH]2)c(=O)[nH]c2cn(C)nc12)c1ncccn1 CHEMBL4568760 IC50 0.2645 nM
COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1F CHEMBL4870179 IC50 0.27 nM
CC(C)[C@H](Nc1c(-c2nc3ccc(N4CCN(C)CC4)cc3[nH]2)c(=O)[nH]c2cn(C)nc12)c1ccccn1 CHEMBL4461304 IC50 0.2885 nM
C[C@@H](Oc1ccc2[nH]nc(/C=C/c3cnn(CCO)c3)c2c1)c1c(Cl)cncc1Cl CHEMBL3828009 IC50 0.29 nM
C=CC(=O)N1CC(n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701241 IC50 0.3 nM
C[C@@H]1CN(c2ccc3nc(-c4c(N[C@@H](C)c5ncccn5)c5nn(C)cc5[nH]c4=O)[nH]c3c2)C[C@H](C)O1 CHEMBL4443370 IC50 0.3731 nM
COc1ccnc(C#CCN(c2ccc3ncc(-c4cnn(C)c4)nc3c2)c2c(F)c(OC)cc(OC)c2F)n1 CHEMBL3978754 pIC50 0.3802 nM
COc1cccnc1C#CCN(c1ccc2ncc(-c3cnn(C)c3)nc2c1)c1c(F)c(OC)cc(OC)c1F CHEMBL3976275 pIC50 0.389 nM
COc1cc(OC)cc(N(CCCN2CCC[C@@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3942763 pIC50 0.389 nM
CNC(=O)c1cncc(-c2cnn3cc(-c4cnn(C(C)C)c4)c(O[C@H]4CCOC4)nc23)c1 CHEMBL5203027 IC50 0.4 nM
C[C@H](Nc1c(-c2nc3c(F)cc(N4CCOCC4)cc3[nH]2)c(=O)[nH]c2cn(C)nc12)c1ncccn1 CHEMBL4529789 IC50 0.41 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3545376 IC50 0.42 nM
COc1cc(OC)cc(N(CCNS(C)(=O)=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921618 pIC50 0.4467 nM
CC(C)(CO)Nc1ccc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nn1 CHEMBL3690444 IC50 0.447 nM
COc1cc(OC)cc(N(CCN2CC[C@H](C#N)C2)c2ccc3ncc(-c4cnn(CC5CCOCC5)c4)nc3c2)c1 CHEMBL3961923 pIC50 0.4571 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4nccc(-n5ccnc5)n4)ccn23)c1 CHEMBL3690562 IC50 0.46 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCCCCC(=O)NO)c4)nc3c2)c1 CHEMBL5177696 IC50 0.46 nM
COc1cc(OC)c(F)c(COc2cnc(Nc3cnn(CCO)c3)nc2)c1F CHEMBL4594428 IC50 0.47 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccc(N5CCCC(O)C5)nn4)ccn23)c1 CHEMBL3690492 IC50 0.484 nM
COc1cc(OC)cc(N(CCC(=O)NCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3937972 pIC50 0.4898 nM
Cn1cnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)c1 CHEMBL3647342 IC50 0.49 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1F CHEMBL4862823 IC50 0.49 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4nnc(NC5CC5)s4)ccn23)c1 CHEMBL3694646 IC50 0.5 nM
C=CC(=O)N1CC[C@H](n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701238 IC50 0.5 nM
COc1cc(C#Cc2cn([C@H]3CCN(C(=O)C#CC(C)(C)O)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701262 IC50 0.5 nM
COc1cc(C)cc2cc(-c3c(CNCC(C)(C)O)c(Cl)n4ncnc(N)c34)sc12 CHEMBL3911335 IC50 0.5 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(CCO)CC5)cc4)c3)c(OCCO)cc21 CHEMBL4294625 IC50 0.5 nM
C=CC(=O)Nc1ccc(/C=C/c2nc(Nc3ncc(C(C)C)s3)cc(N3CCN(C)CC3)n2)cc1 CHEMBL4745451 GI50 0.5 nM
[2H]C([2H])([2H])NC(=O)c1cncc(-c2cnn3cc(-c4cnn(C(C)C)c4)c(O[C@H]4CCOC4)nc23)c1 CHEMBL5180631 IC50 0.5 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3931421 pIC50 0.5129 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3955800 pIC50 0.5129 nM
O=C1CN(c2ccc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)nn2)CCN1 CHEMBL3690458 IC50 0.53 nM
NC1CCN(c2ccc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)nn2)CC1 CHEMBL3690438 IC50 0.535 nM
Nc1nnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)s1 CHEMBL3639935 IC50 0.54 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4cnn(C5CCOC5)c4)ccn23)c1 CHEMBL3690411 IC50 0.542 nM
CN1CCC(n2cc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)cn2)CC1 CHEMBL3686065 IC50 0.545 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccc(N5CCCCC5)nn4)ccn23)c1 CHEMBL3686066 IC50 0.55 nM
CC(=O)N1CCN(c2ccc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)cn2)CC1 CHEMBL3690501 IC50 0.56 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccc(NCCO)nn4)ccn23)c1 CHEMBL3690430 IC50 0.569 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4cnn(C5CCNCC5)c4)ccn23)c1 CHEMBL3686063 IC50 0.57 nM
COc1cc(OC)cc(N(CCCN2CCC(O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3962736 pIC50 0.5754 nM
COc1cc(OC)cc(N(CCCN2CCC(O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3984039 pIC50 0.5754 nM
CCN1CCN(c2cccc(Nc3ncnc(-c4cccnc4Nc4c(Cl)c(OC)cc(OC)c4Cl)n3)c2)CC1 CHEMBL5198569 IC50 0.58 nM
CCN1CCC(/N=C/C(C=N)c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)C1 CHEMBL3690408 IC50 0.582 nM
COc1cc(OC)cc(N(CCCN2CC[C@H](C#N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3969381 pIC50 0.5888 nM
CCS(=O)(=O)NCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3912569 pIC50 0.5888 nM
COc1cc(CCc2cc(NC(=O)c3ccc(N4C[C@@H](C)N[C@@H](C)C4)cc3)n[nH]2)cc(OC)c1 CHEMBL3348846 IC50 0.6 nM
C=CC(=O)Nc1ccc(/C=C/c2nc(Nc3cc(C4COC4)[nH]n3)cc(N3CCN(C)CC3)n2)cc1 CHEMBL4744456 GI50 0.6 nM
C=CC(=O)Nc1ccc(/C=C/c2nc(Nc3cc(CC(C)C)[nH]n3)cc(N3CCN(C)CC3)n2)cc1 CHEMBL4761236 GI50 0.6 nM
C=CC(=O)Nc1ccc(/C=C/c2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)cc1 CHEMBL4756501 GI50 0.6 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3nc(-c4cnn(C)c4)cnc3c2)c1 CHEMBL5189383 IC50 0.6 nM
CNC(=O)c1cc(F)c(F)c(-c2cnc3cc(-c4cnn(C)c4)c(O[C@H]4CCOC4)nn23)c1 CHEMBL5174279 IC50 0.6 nM
COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3ccc(N4C[C@@H](C)N[C@@H](C)C4)cc3)n2)c1Cl CHEMBL5177100 IC50 0.6 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4cnn(C5CCNC5)c4)ccn23)c1 CHEMBL3690409 IC50 0.603 nM
CN1CCCC(/N=C/C(C=N)c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)C1 CHEMBL3690402 IC50 0.61 nM
CN(C)c1ccc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nn1 CHEMBL3690475 IC50 0.61 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4cnn(C5CCCNC5)c4)ccn23)c1 CHEMBL3690404 IC50 0.612 nM
CC(C)N1CC(/N=C/C(C=N)c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)C1 CHEMBL3690397 IC50 0.613 nM
COc1cc(OC)cc(N(CCCN2CCC[C@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3936672 pIC50 0.6166 nM
COc1cc(OC)cc(N(CCCN2CCC[C@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3982740 pIC50 0.6166 nM
COc1cc(OC)cc(N(C[C@@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3913322 pIC50 0.6166 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCOc5ccc(C(=O)NO)cc5)c4)nc3c2)c1 CHEMBL5181688 IC50 0.62 nM
N=C(C/C=C(\N)c1ccn2c(-c3cccc(NC(=O)NCC(F)(F)F)c3)cnc2c1)N1CCOCC1 CHEMBL3690380 IC50 0.64 nM
COCCc1nnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)s1 CHEMBL3694708 IC50 0.643 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(C5CCCCO5)c4)nc3c2)c1 CHEMBL3980232 pIC50 0.6457 nM
CCN1CCN(c2ccc(Nc3cc(N(C)C(=O)Nc4c(Cl)c(OC)cc(OC)c4Cl)ncn3)cc2)CC1 CHEMBL1852688 IC50 0.66 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4nc5c(s4)CNCC5)ccn23)c1 CHEMBL3690416 IC50 0.675 nM
COc1cc(OC)c(Cl)c(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3922586 pIC50 0.6761 nM
COc1cc(OC)c(Cl)c(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3958312 pIC50 0.6761 nM
CCN1CCN(c2ccc(Nc3cc(N(C)C(=O)Nc4c(Cl)c(OC)cc(OC)c4Cl)ncn3)cc2)CC1 CHEMBL1834657 IC50 0.7 nM
COc1cc(C#Cc2cn(C3CN(C(=O)/C=C/CN(C)C)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701267 IC50 0.7 nM
COc1cc(C#Cc2cn(C3CN(C(=O)/C=C/CN4CC[C@H](O)C4)C3)c3ncnc(N)c23)cc(OC)c1 CHEMBL3701274 IC50 0.7 nM
COc1cc(C)cc2cc(-c3c(CNC(C)=O)c(CNC(C)=O)n4ncnc(N)c34)sc12 CHEMBL3929322 IC50 0.7 nM
C=CC(=O)Nc1ccc(/C=C/c2nc(Nc3ncc(C)s3)cc(N3CCN(C)CC3)n2)cc1 CHEMBL4764283 GI50 0.7 nM
C=CC(=O)Nc1ccc(/C=C/c2nc(Nc3cc(C(C)(C)C)[nH]n3)cc(N3CCN(C)CC3)n2)cc1 CHEMBL4781569 GI50 0.7 nM
CNC(=O)c1cc(C)c(F)c(-c2cnc3cc(-c4cnn(C)c4)c(O[C@H]4CCOC4)nn23)c1 CHEMBL5206837 IC50 0.7 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4nnc(CCN5CCCCC5)s4)ccn23)c1 CHEMBL3690387 IC50 0.704 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccc(CCO)cn4)ccn23)c1 CHEMBL3690484 IC50 0.704 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4cnn(CCO)c4)ccn23)c1 CHEMBL3647347 IC50 0.704 nM
COc1cc(OC)cc(N(CC(O)C(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3985678 pIC50 0.7079 nM
COc1cc(OC)cc(N(Cc2cc(C)no2)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3951245 pIC50 0.7079 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3892776 pIC50 0.7079 nM
CNc1ccc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nn1 CHEMBL3690491 IC50 0.71 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccc(N5CCC5)nn4)ccn23)c1 CHEMBL3690445 IC50 0.715 nM
COc1cc(OC)cc(N(CCNS(=O)(=O)N(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3919173 pIC50 0.7244 nM
CN1CCC(Nc2ccc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)nn2)CC1 CHEMBL3690439 IC50 0.73 nM
CN(C)C(=O)C(C)(C)/N=C/C(C=N)c1ccn2c(-c3cccc(NC(=O)NCC(F)(F)F)c3)cnc2c1 CHEMBL3690433 IC50 0.74 nM
COc1cc(OC)cc(N(CCCNC(=O)C(F)(F)F)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3983918 pIC50 0.7762 nM
Cc1nnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)s1 CHEMBL3647338 IC50 0.78 nM
Nc1ccc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc1 CHEMBL3690486 IC50 0.789 nM
Cc1c(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nnn1C CHEMBL3647343 IC50 0.79 nM
COc1cc(F)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3934596 pIC50 0.7943 nM
COc1cc(OC)cc(N(CCC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3951126 pIC50 0.7943 nM
COc1cc(OC)cc(N(CCC#N)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3913757 pIC50 0.7943 nM
C#CCN(c1ccc2ncc(-c3cnn(C)c3)nc2c1)c1c(F)c(OC)cc(OC)c1F CHEMBL3935597 pIC50 0.7943 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)c(=O)n3c2)c1 CHEMBL4862576 IC50 0.8 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4cnn(C5CNC5)c4)ccn23)c1 CHEMBL3690401 IC50 0.807 nM
COc1cc(OC)cc(N(CCCN)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3922285 pIC50 0.8128 nM
COc1cc(OC)cc(N(Cc2ncc[nH]2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3928393 pIC50 0.8128 nM
CN(C)C1CCN(c2ccc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)nn2)CC1 CHEMBL3690400 IC50 0.82 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4nnc(C5CCCO5)s4)ccn23)c1 CHEMBL3686060 IC50 0.83 nM
CC(C)c1cnc(N)nc1-c1ccn2c(-c3cccc(NC(=O)NCC(F)(F)F)c3)cnc2c1 CHEMBL3690590 IC50 0.83 nM
COc1cc(OC)cc(N(CCNCC(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3905866 pIC50 0.8318 nM
COc1cc(O)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3962492 pIC50 0.8318 nM
Cc1ccc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc1 CHEMBL3690454 IC50 0.84 nM
CCOC(=O)C(C)(C)n1cc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)cn1 CHEMBL3686061 IC50 0.85 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCO)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3909565 pIC50 0.8511 nM
COc1cc(OC)cc(N(CC(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3900574 pIC50 0.8511 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCC5CCNCC5)c4)nc3c2)c1 CHEMBL3925306 pIC50 0.871 nM
COc1cc(OC)cc(N(Cc2nnc(N)o2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3968009 pIC50 0.871 nM
COc1cc(OC)cc(N(CCNC(=O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3912831 pIC50 0.871 nM
CCNC(=O)Nc1cccc(-c2cnc3cc(-c4ncc(C(F)(F)F)c(N)n4)ccn23)c1 CHEMBL3690583 IC50 0.88 nM
COCCNc1ccc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nn1 CHEMBL3690443 IC50 0.89 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccc(CCO)cc4)ccn23)c1 CHEMBL3690474 IC50 0.89 nM
COc1cc(OC)cc(N(CC(O)CNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3978453 pIC50 0.8913 nM
COc1cc(OC)cc(N(CC(O)CNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3932112 pIC50 0.8913 nM
COc1cc(OC)cc(N(CCCNS(=O)(=O)N(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3893398 pIC50 0.8913 nM
COc1cc(OC)cc(N(CCN2CCC(O)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3939439 pIC50 0.8913 nM
[2H]C([2H])([2H])Oc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3925081 pIC50 0.8913 nM
COc1cc(C)cc2cc(-c3c(-c4cnco4)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3951786 IC50 0.9 nM
COc1cc(OC)cc(-c2nn(CCCCCN3CCN(C(=O)/C=C/C(F)(F)F)CC3)c3ncnc(N)c23)c1 CHEMBL5088737 IC50 0.9 nM
CNC(=O)c1cccc(-c2cnc3cc(-c4cnn(C)c4)c(O[C@H]4CCOC4)nn23)c1 CHEMBL5200643 IC50 0.9 nM
CNC(=O)c1cc(-c2cnc3cc(-c4cnn(C)c4)c(O[C@H]4CCOC4)nn23)c(F)c(C(F)F)c1 CHEMBL5184953 IC50 0.9 nM
COc1cc(OC)cc(N(CCN2CCC[C@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907195 pIC50 0.912 nM
COc1cc(OC)cc(N(CCN2CCC[C@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3944340 pIC50 0.912 nM
COCCn1cc(-c2cnc3ccc(N(Cc4cc(C)no4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3985692 pIC50 0.912 nM
O=C(NCC(F)(F)F)Nc1cncc(-c2cnc3cc(-c4cnn(C5CCNCC5)c4)ccn23)c1 CHEMBL3690506 IC50 0.93 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccc(CO)cn4)ccn23)c1 CHEMBL3690455 IC50 0.94 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(CCCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921441 pIC50 0.955 nM
Cc1cn2nc(-c3ccn4c(-c5cc(NC(=O)NCC(F)(F)F)cc(OC(C)C)c5)cnc4c3)sc2n1 CHEMBL3694645 IC50 0.96 nM
CCN1C(=O)N(c2c(F)c(OC)cc(OC)c2F)Cc2cnc3[nH]c(CN4CCOCC4)cc3c21 CHEMBL4297522 IC50 0.97 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C5CCNCC5)c4)nc3c2)c1 CHEMBL3969446 pIC50 0.9772 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCCO)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3954298 pIC50 0.9772 nM
[2H]C([2H])([2H])n1cc(-c2ccc3ncc(N(CCO)c4cc(OC)cc(OC)c4)nc3c2)cn1 CHEMBL3959849 pIC50 0.9772 nM
COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3cnn(C4CCNCC4)c3)n2)c1Cl CHEMBL5181852 IC50 0.98 nM
COc1ccc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc1 CHEMBL3690554 IC50 0.99 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4nnc(Nc5cccnc5)s4)ccn23)c1 CHEMBL3694681 IC50 0.99 nM
COCc1cc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc(N)n1 CHEMBL3694722 IC50 0.99 nM
COc1cc(OC)cc(N(Cc2cc(C)no2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3898908 pIC50 1.0 nM
COc1cc(OC)cc(N(CC(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3911635 pIC50 1.0 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4nnc(CCO)s4)ccn23)c1 CHEMBL3694656 IC50 1.0 nM
CNc1cc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc(SC)n1 CHEMBL3690567 IC50 1.0 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CC[C@](C)(N)C1 CHEMBL3985178 IC50 1.0 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(C#Cc4cncc(N5CCOCC5)c4)c3)cc2C(F)(F)F)CC1 CHEMBL4091628 IC50 1.0 nM
CNC(=O)c1cncc(-c2cnn3cc(-c4cnn(C)c4)c(OC4CCOC4)nc23)c1 CHEMBL5199231 IC50 1.0 nM
COc1cc(OC)cc(N(CCCN)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3979013 pIC50 1.023 nM
CN1CC(n2cc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)cn2)C1 CHEMBL3690405 IC50 1.05 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3898881 pIC50 1.072 nM
COc1cc(OC)cc(N(CCCNC(=O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3891892 pIC50 1.072 nM
CCN(c1ccc2ncc(-c3cnn(C)c3)nc2c1)c1cc(OC)cc(OC)c1Cl CHEMBL3922418 pIC50 1.096 nM
COc1cc(OC)cc(N(CCN2CCC[C@@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3898322 pIC50 1.096 nM
COc1cc(OC)cc(N(CCN2CCC[C@@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3954671 pIC50 1.096 nM
COCC(O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3942594 pIC50 1.096 nM
COc1cc(OC)cc(N(C[C@H](O)CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3939764 pIC50 1.096 nM
COc1cc(OC)cc(N(CCNS(=O)(=O)C(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3964574 pIC50 1.096 nM
COC[C@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C(C)C)c3)nc2c1 CHEMBL3926556 pIC50 1.096 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4nc5c(s4)CCC5)ccn23)c1 CHEMBL3690373 IC50 1.1 nM
CN1CCN(c2ccc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)nn2)CC1 CHEMBL3690377 IC50 1.1 nM
CC(C)(C(=O)NC1CC1)n1cc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)cn1 CHEMBL3690434 IC50 1.1 nM
NC(=O)c1ccc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc1 CHEMBL3690557 IC50 1.1 nM
CNC(=O)c1cccc(-c2cnc3cc(-c4cnn(C)c4)c(OC4COC4)nn23)c1 CHEMBL5202943 IC50 1.1 nM
COc1cc(Nc2ncc(CCc3c(F)c(OC)cc(OC)c3F)cn2)ccc1N1CCC(N(C)C2CCN(C)CC2)CC1 CHEMBL5182779 IC50 1.1 nM
COc1cc(Nc2ncc(OCc3c(F)c(OC)cc(OC)c3F)cn2)ccc1N1CCC(N2CCN(C)CC2)CC1 CHEMBL5170802 IC50 1.1 nM
CCOc1cc(Nc2ncc(OCc3c(F)c(OC)cc(OC)c3F)cn2)ccc1N1CCC(N2CCN(C)CC2)CC1 CHEMBL5182060 IC50 1.1 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3958153 pIC50 1.122 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCCN5CCOCC5)c4)nc3c2)c1 CHEMBL3927327 pIC50 1.122 nM
COc1cc(OC)cc(N(CC(=O)Nc2cc(O)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3894762 pIC50 1.122 nM
COc1cc(OC)cc(N(CCCN2CCCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3904674 pIC50 1.148 nM
COc1cc(OC)cc(N(Cc2cn(CCO)nn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921457 pIC50 1.148 nM
CC(C)(C(=O)O)n1cc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)cn1 CHEMBL3686064 IC50 1.15 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3918751 pIC50 1.175 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3949470 pIC50 1.175 nM
COc1cc(OC)c(Cl)c(CCc2cc(-c3nc4ccc(N5CCN(C)CC5)cc4[nH]3)n[nH]2)c1Cl CHEMBL5205436 IC50 1.19 nM
COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3cnn(CCCN(C)C)c3)n2)c1Cl CHEMBL5200941 IC50 1.19 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccccn4)ccn23)c1 CHEMBL3686062 IC50 1.2 nM
O=C(NCC(F)(F)F)Nc1cncc(-c2cnc3cc(-c4cnn(C5CNC5)c4)ccn23)c1 CHEMBL3690485 IC50 1.2 nM
Cc1cn2nc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)sc2n1 CHEMBL3690574 IC50 1.2 nM
CC(=O)N1CCN(Cc2ccc3cc(C(=O)c4cnn(-c5ccc6[nH]c(C)nc6c5)c4N)[nH]c3c2)CC1 CHEMBL3681290 IC50 1.2 nM
COc1cc(Nc2ncc(CCc3c(F)c(OC)cc(OC)c3F)cn2)ccc1N1CCC(N2CCN(C)CC2)CC1 CHEMBL4763773 IC50 1.2 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1Cl CHEMBL4863146 IC50 1.2 nM
COc1cc(OC)c(F)c(COc2cnc(Nc3cnn(CCN4CCNCC4)c3)nc2)c1F CHEMBL5201061 IC50 1.2 nM
COc1cc(OC)cc(N(CCCNS(C)(=O)=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3896104 pIC50 1.202 nM
COc1cc(OC)cc(N(CCNC(C)=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3945373 pIC50 1.202 nM
COc1cc(OC)cc(N(CCC(C)(C)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3950910 pIC50 1.202 nM
COc1cc(O)cc(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3964096 pIC50 1.202 nM
COc1cc(OC)cc(N(CC#CC(C)(C)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3924172 pIC50 1.202 nM
COc1cc(OC)cc(N(CCF)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3891525 pIC50 1.202 nM
COc1cc(OC)cc(N(CC#CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3895267 pIC50 1.202 nM
COc1cc(OC)cc(N(CCCNCC(N)=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3960877 pIC50 1.202 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC5CCN(C)CC5)c4)nc3c2)c1 CHEMBL3948321 pIC50 1.23 nM
COc1cc(O)cc(N(CCCO)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3897155 pIC50 1.23 nM
Cc1nc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)c(C)n1C CHEMBL3647349 IC50 1.24 nM
CC(C)(C)OC(=O)N1CCc2nc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)sc2C1 CHEMBL3690417 IC50 1.25 nM
CNC(=O)C(C)(C)/N=C/C(C=N)c1ccn2c(-c3cccc(NC(=O)NCC(F)(F)F)c3)cnc2c1 CHEMBL3690432 IC50 1.25 nM
COc1cc(OC)cc(N(CCCC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3955706 pIC50 1.259 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3898355 pIC50 1.259 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3961210 pIC50 1.259 nM
COc1cc(OC)cc(N(Cc2cccnc2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3928239 pIC50 1.259 nM
COc1cc(OC)cc(N(C[C@@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(CCCN)c4)nc3c2)c1 CHEMBL3964701 pIC50 1.259 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCN5CCN(CCO)CC5)c4)nc3c2)c1 CHEMBL3937533 pIC50 1.288 nM
COc1cc(OC)cc(N(CCCN)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3966748 pIC50 1.288 nM
CC(C)(C)OC(=O)N1CCCC(n2cc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)cn2)C1 CHEMBL3690403 IC50 1.3 nM
Cc1ccnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)c1 CHEMBL3690460 IC50 1.3 nM
Nc1ccnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)c1 CHEMBL3690471 IC50 1.3 nM
CSc1nc(N)cc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)n1 CHEMBL3690555 IC50 1.3 nM
Nc1nc(-c2ccn3c(-c4cc(F)cc(NC(=O)NCC(F)(F)F)c4)cnc3c2)ncc1F CHEMBL3694696 IC50 1.3 nM
C=CC(=O)Nc1ccc(/C=C/c2nc(Nc3cc(COC)[nH]n3)cc(N3CCN(C)CC3)n2)cc1 CHEMBL4777595 GI50 1.3 nM
CNC(=O)c1cc(C)cc(-c2cnc3cc(-c4cnn(C(C)C)c4)c(O[C@H]4CCOC4)nn23)c1 CHEMBL5187371 IC50 1.3 nM
COc1cc(Nc2ncc(OCc3c(F)c(OC)cc(OC)c3F)cn2)cnc1N1CCC(N2CCN(C)CC2)CC1 CHEMBL5197399 IC50 1.3 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(CCCN)c4)nc3c2)c1 CHEMBL3927875 pIC50 1.318 nM
COc1cc(OC)cc(N(Cc2cc(C)on2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3979490 pIC50 1.318 nM
COc1cc(OC)cc(N(CCCN2CCC(F)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3975447 pIC50 1.318 nM
COc1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cnn(CC5CCOCC5)c4)nc3c2)c1 CHEMBL3966305 pIC50 1.318 nM
CCCn1cc(-c2cnc3ccc(N(CCN)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3959573 pIC50 1.318 nM
COc1cc(OC)cc(N(CCCN2CCC(N3CCCCC3)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3971277 pIC50 1.349 nM
COc1cc(OC)cc(N(CCCN2CCC(N3CCCCC3)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3927947 pIC50 1.349 nM
COc1cc(OC)cc(N(CCCN2CC(O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907314 pIC50 1.349 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC(=O)N(C)C)c4)nc3c2)c1 CHEMBL3925254 pIC50 1.38 nM
CCn1cc(-c2cnc3ccc(N(CCNC(C)C)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3945159 pIC50 1.38 nM
Nc1cccc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)n1 CHEMBL3690469 IC50 1.39 nM
COc1cc(C)cc2cc(-c3c(CN4CCNC(=O)C4)c(C(C)(C)O)n4ncnc(N)c34)sc12 CHEMBL3920417 IC50 1.4 nM
COc1cc(C)cc2cc(-c3c(CN4CCNC(=O)C4)c(C)n4ncnc(N)c34)sc12 CHEMBL3943773 IC50 1.4 nM
C=CC(=O)Nc1ccc(/C=C/c2nc(Nc3cc(C)[nH]n3)cc(N3CCN(C)CC3)n2)cc1 CHEMBL4793382 GI50 1.4 nM
COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1 CHEMBL4863224 IC50 1.4 nM
COc1cc(Nc2ncc(CCc3c(F)c(OC)cc(OC)c3F)cn2)ccc1N1CCN(C2CCN(C)CC2)CC1 CHEMBL5194555 IC50 1.4 nM
C=CCn1cc(Nc2ncnc(-c3cccnc3Nc3c(Cl)c(OC)cc(OC)c3Cl)n2)cn1 CHEMBL5204120 IC50 1.41 nM
COc1cc(OC)cc(N(CCCN2CCC(N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3919730 pIC50 1.413 nM
COc1cc(OC)cc(N(CCCN2CCC(N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3967645 pIC50 1.413 nM
COc1cc(OC)cc(N(Cc2cn[nH]n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3904561 pIC50 1.413 nM
COc1cc(OC)cc(N(Cc2csc(C)n2)c2ccc3ncc(-c4cnn(CCN5CCNCC5)c4)nc3c2)c1 CHEMBL3921197 pIC50 1.413 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C5CCN(C(=O)OC(C)(C)C)CC5)c4)nc3c2)c1 CHEMBL3977010 pIC50 1.413 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C5CCN(C)CC5)c4)nc3c2)c1 CHEMBL3967761 pIC50 1.413 nM
COC[C@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CCCN)c3)nc2c1 CHEMBL3916200 pIC50 1.413 nM
COc1cc(OC)cc(N(C/C(C)=N\O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3948270 pIC50 1.445 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC(=O)N5CCC(O)C5)c4)nc3c2)c1 CHEMBL3929803 pIC50 1.445 nM
COc1cc(OC)cc(N(CCCN)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3922698 pIC50 1.445 nM
CC(C)(/N=C/C(C=N)c1ccn2c(-c3cccc(NC(=O)NCC(F)(F)F)c3)cnc2c1)C(N)=O CHEMBL3690435 IC50 1.45 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3893008 pIC50 1.479 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCCN)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3942328 pIC50 1.479 nM
COc1cc(OC)cc(N(CC(F)CN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3908149 pIC50 1.479 nM
Cc1nc(N)cc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)n1 CHEMBL3690558 IC50 1.5 nM
COc1cc(Nc2ncc(CCc3c(F)c(OC)cc(OC)c3F)cn2)ccc1N1CCN(C)CC1 CHEMBL5193271 IC50 1.5 nM
COc1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3890896 pIC50 1.514 nM
COc1cc(OC)cc(N(CCCN2CCCC(C#N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3925008 pIC50 1.514 nM
CNCCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3968499 pIC50 1.514 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C([2H])([2H])C([2H])([2H])O)c1 CHEMBL3946938 pIC50 1.514 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccncc4)ccn23)c1 CHEMBL3690446 IC50 1.54 nM
COc1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3951694 pIC50 1.549 nM
COc1cc(OC)cc(N(CCP(=O)(O)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3950169 pIC50 1.549 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 1.585 nM
COc1cc(OC)cc(N(CCNC(=O)C2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3963323 pIC50 1.585 nM
CNC(=O)c1cc(F)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3946103 pIC50 1.585 nM
COc1cc(OC)c(F)c(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1F CHEMBL3903973 pIC50 1.585 nM
COc1cc(OC)cc(N(CCS(C)(=O)=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3942716 pIC50 1.585 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(N6CCOCC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681284 IC50 1.6 nM
NCCn1cc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)cn1 CHEMBL3647353 IC50 1.6 nM
COc1cc(Nc2ncc(CCc3c(F)c(OC)cc(OC)c3Cl)cn2)ccc1N1CCC(N2CCN(C)CC2)CC1 CHEMBL4746045 IC50 1.6 nM
COc1cc(Nc2ncc(OCc3c(F)c(OC)cc(OC)c3F)cn2)ccc1N1CCN(C)CC1 CHEMBL5171147 IC50 1.6 nM
C#CCO[C@@H]1[C@H](C)[C@@H](COC(=O)c2ccc(S(=O)(=O)F)cc2)O[C@H]1n1nc(-c2ccc(C)cc2)c2c(N)ncnc21 CHEMBL5268244 IC50 1.6 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3901627 pIC50 1.622 nM
COc1cc(OC)cc(N(CC(O)CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3943387 pIC50 1.622 nM
CCn1cc(-c2cnc3ccc(N(CCN)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3950089 pIC50 1.622 nM
COc1cc(OC)cc(N(CCCN2CCC(S(C)(=O)=O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3933707 pIC50 1.622 nM
N#Cc1ccc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nn1 CHEMBL3694650 IC50 1.65 nM
COc1cc(OC)cc(N(Cc2cnccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3890378 pIC50 1.66 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C5CCNCC5)c4)nc3c2)c1 CHEMBL3897783 pIC50 1.66 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccc(OC5CCCNC5)nn4)ccn23)c1 CHEMBL3690490 IC50 1.66 nM
CNC(=O)c1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3902581 pIC50 1.698 nM
COc1cc(OC)cc(N(CCCNC(=O)C(C)(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3935825 pIC50 1.698 nM
COc1cc(OC)cc(N(CCCNC(=O)C(C)(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3897101 pIC50 1.698 nM
COc1cc(OC)cc(N(CCCN2CCC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3906894 pIC50 1.698 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCC#N)c4)nc3c2)c1 CHEMBL3958209 pIC50 1.698 nM
C=CC(=O)Nc1ccccc1C(=O)Nc1cc(CCc2cc(OC)cc(OC)c2)[nH]n1 CHEMBL4284069 IC50 1.7 nM
COc1cc(OC)c(F)c(COc2cnc(Nc3ccc(N4CCC(N5CCN(C)CC5)CC4)c(C)c3)nc2)c1F CHEMBL5207973 IC50 1.7 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCN5CCNCC5)c4)nc3c2)c1 CHEMBL3985853 pIC50 1.738 nM
COc1cc(OC)cc(N(CCCNCC(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3934080 pIC50 1.738 nM
COc1ccc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nn1 CHEMBL3690414 IC50 1.74 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccc(F)cn4)ccn23)c1 CHEMBL3690459 IC50 1.75 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC5(OC)CCNCC5)c4)nc3c2)c1 CHEMBL3908326 pIC50 1.778 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC(O)CN5CCCCC5)c4)nc3c2)c1 CHEMBL3964675 pIC50 1.778 nM
COc1cc(OC)cc(N(Cc2csc(C)n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3961872 pIC50 1.778 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3970430 pIC50 1.778 nM
COc1cc(OC)cc(N(C[C@@H](O)CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3967739 pIC50 1.778 nM
COc1cc(OC)cc(N(CCCN2CCC[C@@H]2CC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3948744 pIC50 1.778 nM
COCC(O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C(C)C)c3)nc2c1 CHEMBL3984461 pIC50 1.778 nM
COCC(O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C(C)C)c3)nc2c1 CHEMBL3981955 pIC50 1.778 nM
CC(C)(O)c1cccc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)c1 CHEMBL3694709 IC50 1.8 nM
COc1cc(C)cc2cc(-c3c(CNCC(C)(C)O)c(CN4CCN(C(C)=O)CC4)n4ncnc(N)c34)sc12 CHEMBL3949626 IC50 1.8 nM
CCNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)ncc1NC(=O)c1nc(OC)cc(OC)n1 CHEMBL4635544 IC50 1.8 nM
COc1cc(OC)cc(N(CCN2CCC(O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3959345 pIC50 1.82 nM
COc1cc(OC)cc(N(CCN2CCC(O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3925286 pIC50 1.82 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC(=O)NCCO)c4)nc3c2)c1 CHEMBL3985750 pIC50 1.82 nM
COc1cc(OC)c(C)c(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3932285 pIC50 1.82 nM
COc1cc(OC)cc(N(CCCN2CCC[C@H]2CC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921476 pIC50 1.82 nM
CCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3931533 pIC50 1.862 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3918092 pIC50 1.862 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C5CN(CCO)C5)c4)nc3c2)c1 CHEMBL3906122 pIC50 1.862 nM
COc1cc(OC)cc(N(CCN2CC[C@H](C#N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3960327 pIC50 1.862 nM
COc1cc(OC)c(Cl)c(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1Cl CHEMBL3978617 pIC50 1.862 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4nncs4)ccn23)c1 CHEMBL3647344 IC50 1.9 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC5CCOCC5)c4)nc3c2)c1 CHEMBL3928646 pIC50 1.905 nM
COc1cc(OC)cc(N(C/C(C)=N/O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3955817 pIC50 1.905 nM
CCN1CCN(c2ccc(Nc3ncnc(-c4cccnc4Nc4c(Cl)c(OC)cc(OC)c4Cl)n3)cc2)CC1 CHEMBL5179166 IC50 1.93 nM
COc1cc(OC)cc(N(CC(C)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3904329 pIC50 1.95 nM
COc1cc(F)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3918739 pIC50 1.95 nM
COc1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3941700 pIC50 1.95 nM
COc1cc(OC)cc(N(CCCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3934260 pIC50 1.95 nM
COc1cc(OC)cc(N(Cc2ccco2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3975954 pIC50 1.995 nM
COc1cc(OC)cc(N(CCCNC(C)(C)CF)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921469 pIC50 1.995 nM
C[C@@H](Oc1ccc2[nH]nc(-c3nc4cc(N5CCN(C)CC5)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3827178 IC50 2.0 nM
CN(C)Cc1cnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc1N CHEMBL3694654 IC50 2.0 nM
COc1cc(C)cc2cc(-c3c(CN[C@@H]4CCNC4=O)c(CN4CCN(C(C)=O)CC4)n4ncnc(N)c34)sc12 CHEMBL4108692 IC50 2.0 nM
COc1cc(C)cc2cc(-c3c(CNCC(C)(C)O)c(C)n4ncnc(N)c34)sc12 CHEMBL3906839 IC50 2.0 nM
COCCN1CCN(c2ccc(C(=O)Nc3n[nH]c4nc(-c5c(Cl)c(OC)cc(OC)c5Cl)ccc34)cc2)CC1 CHEMBL4447359 IC50 2.0 nM
COc1cc(OC)c(F)c(COc2cnc(Nc3ccc(N4CCC(N5CCN(C)CC5)CC4)nc3)nc2)c1F CHEMBL5191170 IC50 2.0 nM
CN1C[C@@H]2CC[C@H](C1=O)N2c1ncc2[nH]nc(-c3cnn(C4CCC4)c3)c2n1 CHEMBL5286909 IC50 2.0 nM
CNC(=O)C(C)(C)n1cc(-c2cnc3ccc(N(CC4CC4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3948623 pIC50 2.042 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C([2H])([2H])C([2H])([2H])C([2H])([2H])O)c1 CHEMBL3906284 pIC50 2.042 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC5(O)CCNCC5)c4)nc3c2)c1 CHEMBL3911573 pIC50 2.089 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3955563 pIC50 2.089 nM
COc1cc(OC)cc(N(CCN2CCC(N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3983996 pIC50 2.089 nM
COc1cc(OC)cc(N(CCC2CCN(C(C)C)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3970423 pIC50 2.089 nM
COc1cc(OC)c(F)c(N(CCCNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1F CHEMBL3892529 pIC50 2.089 nM
Cc1nc2cc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)ccc2s1 CHEMBL3690568 IC50 2.1 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1Cl CHEMBL3916756 IC50 2.1 nM
COc1cc(OC)cc(N(CCCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3909529 pIC50 2.138 nM
COc1cc(OC)cc(N(CCC2CCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3915268 pIC50 2.138 nM
COc1cc(OC)cc(N(CCNC(=O)C(C)(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3899692 pIC50 2.138 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(/C=C/c4ccccn4)ccn23)c1 CHEMBL3690538 IC50 2.18 nM
Cc1cn(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)cn1 CHEMBL3647350 IC50 2.18 nM
COc1cc(OCCO)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3974693 pIC50 2.188 nM
COc1cc(OCCO)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3903768 pIC50 2.188 nM
COc1cc(OC)cc(N(C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3947740 pIC50 2.188 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C2COC2)c1 CHEMBL3985259 pIC50 2.188 nM
COc1cc(OC)cc(N(CCCN2CCCC(C(N)=O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3910444 pIC50 2.188 nM
COc1cc(O)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3893642 pIC50 2.188 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCCNC(C)C)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3925114 pIC50 2.188 nM
CC(=O)c1cnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc1N CHEMBL3694698 IC50 2.2 nM
C=CC(=O)N1CCN(CCCn2c(=O)c(-c3c(Cl)c(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)CC1 CHEMBL4068509 Ki 2.2 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1 CHEMBL4847441 IC50 2.2 nM
CNC(=O)c1cncc(-c2cnc3cc(-c4cnn(C)c4)c(OC4CCOC4)nn23)c1 CHEMBL5208443 IC50 2.2 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C(C)(C)C(=O)NCCO)c4)nc3c2)c1 CHEMBL3976219 pIC50 2.239 nM
CNC(=O)c1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(CCOC)c4)nc3c2)c1 CHEMBL3908529 pIC50 2.239 nM
COc1cc(OC)cc(N(CCCN2CCOCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3928261 pIC50 2.239 nM
COc1cc(OC)cc(N(CCN2CC=CCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3979670 pIC50 2.239 nM
Nc1nc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)ncc1CN1CCC1 CHEMBL3694653 IC50 2.24 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccc(N5CCCCC5)nc4)ccn23)c1 CHEMBL3690413 IC50 2.25 nM
NC(=O)Nc1cccc(-c2cnc3cc(-c4ccc(F)cc4)ccn23)c1 CHEMBL3690507 IC50 2.28 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCCN)c4)nc3c2)c1 CHEMBL3898120 pIC50 2.291 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC5CCNCC5)c4)nc3c2)c1 CHEMBL3976280 pIC50 2.291 nM
COc1cc(OC)cc(N(CCCN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3937633 pIC50 2.291 nM
COc1cc(OC)cc(N(CCCN2CCC[C@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3949132 pIC50 2.291 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCCN4CCCC4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3972979 pIC50 2.291 nM
COc1cc(OC)cc(N(CCn2cccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3933341 pIC50 2.291 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CC5CCOCC5)c4)nc3c2)c1 CHEMBL3926082 pIC50 2.291 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccc(OC5CCNCC5)nn4)ccn23)c1 CHEMBL3690489 IC50 2.3 nM
COc1cc(OC)cc(N(CC#Cc2cc(OC)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3927140 pIC50 2.344 nM
COc1cc(OC)cc(N(CCNC2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3918495 pIC50 2.344 nM
COc1cc(OC)cc(N(C[C@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3916037 pIC50 2.344 nM
COc1cc(OC)cc(N(C[C@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(CCCN)c4)nc3c2)c1 CHEMBL3950510 pIC50 2.344 nM
COc1cc(OC)cc(N(CC(O)CN2CCC(F)(F)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3915533 pIC50 2.399 nM
COc1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3987037 pIC50 2.399 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC(O)CO)c4)nc3c2)c1 CHEMBL3889493 pIC50 2.399 nM
COc1cc(OC)cc(N(CCCN2CCCCC2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3905485 pIC50 2.399 nM
CNC[C@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3968124 pIC50 2.399 nM
COc1cc(OC)cc(N(CCN2CCCC(C(N)=O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3931790 pIC50 2.399 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCN5CCN(CCO)CC5)c4)nc3c2)c1 CHEMBL3957473 pIC50 2.399 nM
CN(C)CCCOc1ccc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)cn1 CHEMBL3690500 IC50 2.4 nM
CNC(=O)c1cccc(-c2cnc3cc(-c4cnn(C)c4)c(OC4CCOC4)nn23)c1 CHEMBL5196280 IC50 2.4 nM
COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3cnn(C)c3)n2)c1Cl CHEMBL5193739 IC50 2.41 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccc(=O)[nH]n4)ccn23)c1 CHEMBL3690415 IC50 2.45 nM
COc1cc(OC)cc(N(CC#Cc2cc(C(N)=O)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921190 pIC50 2.455 nM
CCOc1ccnc(C#CCN(c2cc(OC)cc(OC)c2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)n1 CHEMBL3894754 pIC50 2.455 nM
COc1cc(OC)cc(N(Cc2csc(C)n2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3929914 pIC50 2.455 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C(C)CNCC(F)(F)F)c1 CHEMBL3890852 pIC50 2.455 nM
CNc1ncc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)cc1C CHEMBL3690513 IC50 2.48 nM
Nc1cc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)ncc1C(F)(F)F CHEMBL3690582 IC50 2.5 nM
COCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CC[C@](C)(N)C1 CHEMBL3938823 IC50 2.5 nM
COc1cc(C)cc2cc(-c3c(COCC(F)(F)F)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3889953 IC50 2.5 nM
COc1cc(C)cc2cc(-c3c(CNCC(C)O)c(CN4CCOCC4)n4ncnc(N)c34)sc12 CHEMBL3944881 IC50 2.5 nM
COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3cnn(C4CCOCC4)c3)n2)c1Cl CHEMBL5174975 IC50 2.51 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3cc(F)c4[nH]c(C)cc4c3)csc12 CHEMBL2006778 pKi 2.512 nM
COc1cc(OC)cc(N(CCCN2CCCC2=O)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3904294 pIC50 2.512 nM
COc1cc(OC)cc(N(CCCN2CC=CCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3919479 pIC50 2.512 nM
COC[C@@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C(C)C)c3)nc2c1 CHEMBL3965482 pIC50 2.512 nM
COc1cc(OC)cc(N(CCCNCCC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3899151 pIC50 2.512 nM
COc1cc(OC)cc(N(CCNCC(N)=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3951253 pIC50 2.512 nM
Cc1cccc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)n1 CHEMBL3690461 IC50 2.55 nM
COCCNC(=O)C(C)(C)n1cc(-c2cnc3ccc(N(CC4CC4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3962805 pIC50 2.57 nM
COc1cc(OC)cc(N(Cc2ccc(Cl)nc2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907642 pIC50 2.57 nM
COc1cc(OC)cc(N(CCNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3950156 pIC50 2.57 nM
C#CCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CC4CCOCC4)c3)nc2c1 CHEMBL3939018 pIC50 2.57 nM
Nc1nc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)ncc1C(=O)O CHEMBL3694669 IC50 2.6 nM
Cc1ccc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nn1 CHEMBL3647351 IC50 2.6 nM
CNC(=O)c1ccc(F)c(-c2cnc3cc(-c4cnn(C)c4)c(OC)nn23)c1 CHEMBL5202408 IC50 2.6 nM
CCNC(=O)c1cncc(-c2cnn3cc(-c4cnn(CC)c4)c(O[C@H]4CCOC4)nc23)c1 CHEMBL5172121 IC50 2.6 nM
COc1cc(OC)cc(N(CCN2C[C@H](C)C[C@H](C)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3901357 pIC50 2.63 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC(=O)NCCN5CCCC5)c4)nc3c2)c1 CHEMBL3951714 pIC50 2.63 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCNS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3966022 pIC50 2.63 nM
CNCC(O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3932577 pIC50 2.63 nM
COc1cc(OC)cc(N(CCc2nnn[nH]2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3905212 pIC50 2.63 nM
CNC(=O)c1cc(F)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3944438 pIC50 2.63 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4cccc(CCO)c4)ccn23)c1 CHEMBL3690470 IC50 2.68 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccc(=O)n(CCO)n4)ccn23)c1 CHEMBL3690488 IC50 2.68 nM
CNC(=O)OCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3973531 pIC50 2.692 nM
COc1cc(OC)cc(N(CCCCN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3969373 pIC50 2.692 nM
COc1cc(OC)cc(N(CCCN2CCC(C(F)(F)F)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3936087 pIC50 2.692 nM
COc1cc(F)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3950069 pIC50 2.692 nM
COc1cc(OC)cc(N(CCCN2CCC[C@H]2CNS(=O)(=O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3933000 pIC50 2.692 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCNCC1 CHEMBL3924399 IC50 2.7 nM
COc1cc(OC)c(F)c(COc2cnc(Nc3cnn(CCNC4CCN(C)CC4)c3)nc2)c1F CHEMBL5197909 IC50 2.7 nM
C=CC(=O)N1CCN(CCCCCn2nc(-c3cc(OC)cc(OC)c3)c3c(N)ncnc32)CC1 CHEMBL5084546 IC50 2.74 nM
COc1cc(OC)cc(N(CCNC2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3923296 pIC50 2.754 nM
[2H]C([2H])([2H])Oc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3975791 pIC50 2.754 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3947189 pIC50 2.754 nM
CNC[C@@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3965710 pIC50 2.754 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3893786 pIC50 2.754 nM
COc1cc(OC)cc(N(CCCc2ccncc2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3920637 pIC50 2.754 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4cccnc4)ccn23)c1 CHEMBL3690441 IC50 2.79 nM
CCN(CC)CCNC(=O)C(C)(C)/N=C/C(C=N)c1ccn2c(-c3cccc(NC(=O)NCC(F)(F)F)c3)cnc2c1 CHEMBL3690431 IC50 2.8 nM
COc1cccc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)n1 CHEMBL3690464 IC50 2.8 nM
Cc1cc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc(C(C)C)n1 CHEMBL3690575 IC50 2.8 nM
CC(C)(O)c1cnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc1 CHEMBL3694651 IC50 2.8 nM
CCNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)ncc1CCc1cc(OC)cc(OC)c1 CHEMBL4634918 IC50 2.8 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3955288 pIC50 2.818 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CC4CC4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3907600 pIC50 2.818 nM
C#CCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3900620 pIC50 2.818 nM
COc1cc(OC)cc(N(CCN2CC[C@H](C#N)C2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3898568 pIC50 2.818 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C([2H])([2H])C([2H])([2H])NC(C)C)c1 CHEMBL3918638 pIC50 2.818 nM
CCN1CCN(c2ccc(Nc3cc(-c4cccnc4Nc4c(Cl)c(OC)cc(OC)c4Cl)ncn3)cc2)CC1 CHEMBL5194218 IC50 2.86 nM
Cc1cc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)cnc1N(C)C(=O)OC(C)(C)C CHEMBL3690504 IC50 2.88 nM
CNC(=O)c1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3986607 pIC50 2.884 nM
COc1cc(OC)cc(N(CC2CCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3951316 pIC50 2.884 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCCN5CCN(CCCO)CC5)c4)nc3c2)c1 CHEMBL3908829 pIC50 2.884 nM
CNC(=O)Cn1cc(-c2ccc3ncc(N(CCN)c4cc(OC)cc(OC)c4)nc3c2)cn1 CHEMBL3976053 pIC50 2.884 nM
[2H]C([2H])([2H])n1cc(-c2cnc3ccc(N(CCNC(C)C)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3919709 pIC50 2.884 nM
COc1cc(C)cc2cc(-c3c(CNC(C)=O)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3934668 IC50 2.9 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C(C)C)c3)nc2c1 CHEMBL3896052 pIC50 2.951 nM
COc1cc(OC)cc(N(C[C@@H](O)CNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3891966 pIC50 2.951 nM
COc1cc(OC)cc(N(CCC(=O)N(C)OC)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3956493 pIC50 2.951 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 IC50 3.0 nM
CNC(=O)c1ccnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)n1 CHEMBL3690569 IC50 3.0 nM
COc1cc(OCCO)cc(N(CCCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3935912 pIC50 3.02 nM
COCCn1cc(-c2cnc3ccc(N(CC4CC4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3986163 pIC50 3.02 nM
COc1cc(OCCO)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3924872 pIC50 3.02 nM
COCCNC(=O)Cn1cc(-c2cnc3ccc(N(CC4CC4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3983115 pIC50 3.02 nM
COc1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3908877 pIC50 3.02 nM
COc1cc(OC)cc(N(C[C@@H]2C[C@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3913970 pIC50 3.02 nM
[2H]C([2H])([2H])Oc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3981418 pIC50 3.02 nM
CNC(=O)c1cc(F)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3918704 pIC50 3.02 nM
COc1cc(OC)cc(N(CCN2CCC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3939200 pIC50 3.02 nM
COc1cc(OC)cc(N(CCN2CC3(COC3)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3934487 pIC50 3.02 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccncn4)ccn23)c1 CHEMBL3690398 IC50 3.05 nM
N#Cc1cnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc1N CHEMBL3690517 IC50 3.05 nM
COc1cc(CCc2cc(-c3nc4ccc(N5CCN(C)CC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5199374 IC50 3.05 nM
CNC1CCN(CCCN(c2cc(OC)cc(OC)c2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)C1 CHEMBL3922453 pIC50 3.09 nM
COc1cc(OC)cc(N(CCN2CCC(CO)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3917141 pIC50 3.09 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)[C@H]2CC[C@@H](NC(C)C)CC2)c1 CHEMBL3911621 pIC50 3.09 nM
COc1cc(OC)cc(N(CC2COCC(C)(C)N2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3901119 pIC50 3.09 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CCOCC5)c4)nc3c2)c1 CHEMBL3913492 pIC50 3.09 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5cc(C(=O)N6CCCC(F)(F)C6)ccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3676320 IC50 3.1 nM
COc1cc(C)cc2cc(-c3c(CNC(C)=O)c(CN4CCN(C=O)CC4)n4ncnc(N)c34)sc12 CHEMBL3968059 IC50 3.1 nM
C=CC(=O)N1CCC(C2CCN(c3nc(Nc4cc(C(C)C)[nH]n4)cc(N4CCN(C)CC4)n3)CC2)C1 CHEMBL4755567 GI50 3.1 nM
c1ccc(CNc2nc(Nc3cc(C4CC4)[nH]n3)c3sccc3n2)cc1 CHEMBL1997924 pKi 3.162 nM
CNCC(O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3935264 pIC50 3.162 nM
COc1cc(OC)cc(N(CCC(=O)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3944224 pIC50 3.162 nM
COc1cc(OC)cc(N(CCN2CCCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3957264 pIC50 3.162 nM
COc1cc(OC)cc(N(CC(O)CN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3936828 pIC50 3.162 nM
COc1cc(OC)cc(N(CCN2CCC(N(C)C)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3958708 pIC50 3.162 nM
COc1cc(OC)cc(N(CCNCCC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3951847 pIC50 3.162 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CCN(C(=O)OC(C)(C)C)CC5)c4)nc3c2)c1 CHEMBL3896249 pIC50 3.162 nM
CN(C)S(=O)(=O)n1ccnc1-c1ccnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)n1 CHEMBL3690565 IC50 3.2 nM
CN1CC2CCC(C1=O)N2c1ncc2[nH]nc(-c3cnn(C4CCC4)c3)c2n1 CHEMBL5275335 IC50 3.2 nM
COc1cc(OC)cc(N(CCCN2CC(F)(F)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3967011 pIC50 3.236 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3892018 pIC50 3.236 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCN5CCCC5)c4)nc3c2)c1 CHEMBL3962814 pIC50 3.236 nM
COc1cc(OC)cc(N(C[C@H](O)CN2CC[C@H](C#N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3980252 pIC50 3.236 nM
COc1cc(OC)cc(N(CCNCCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3944610 pIC50 3.236 nM
COc1cc(F)cc(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3974206 pIC50 3.236 nM
COc1cc(OC)cc(N(CCN(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3952277 pIC50 3.236 nM
COc1cc(OC)cc(N(CCCNCC(C)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3966200 pIC50 3.236 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccc(F)cc4)ccn23)c1 CHEMBL3647337 IC50 3.3 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ncns4)ccn23)c1 CHEMBL3647352 IC50 3.3 nM
COCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCNCC1 CHEMBL3892887 IC50 3.3 nM
COc1cc(OC)cc(N(CCN2CCOCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3982668 pIC50 3.311 nM
COc1cc(F)cc(N(CCCO)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3897034 pIC50 3.311 nM
COc1cc(OC)cc(N(C[C@@H](O)CNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3903811 pIC50 3.311 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4CCO)nc3c2)c1 CHEMBL3935838 pIC50 3.311 nM
COc1cc(OC)cc(N(CC#Cc2cc(N)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3902961 pIC50 3.311 nM
COc1cc(OC)cc(N(CCC(=O)NC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3947664 pIC50 3.311 nM
COc1cc(OC)cc(N(CC#Cc2cc(CO)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3980417 pIC50 3.388 nM
COCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3933449 pIC50 3.388 nM
COc1cc(OCCO)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3891619 pIC50 3.388 nM
COc1cc(OC)cc(N(CCNCC2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3935457 pIC50 3.388 nM
COc1cc(F)cc(N(CCCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3902110 pIC50 3.388 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CCNCC5)c4)nc3c2)c1 CHEMBL3980069 pIC50 3.388 nM
COc1cc(OC)cc(N(Cc2cc3ncccc3[nH]2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3939860 pIC50 3.388 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4cc(C(F)(F)F)ncn4)ccn23)c1 CHEMBL3690576 IC50 3.4 nM
COc1cc(C)cc2cc(-c3c(CNCC4CC4)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3952635 IC50 3.4 nM
C=CC(=O)N1CCN(CCCCCCCn2nc(-c3cc(OC)cc(OC)c3)c3c(N)ncnc32)CC1 CHEMBL5091141 IC50 3.4 nM
Cc1cc(C)nc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)c1 CHEMBL3690503 IC50 3.45 nM
COc1cc(OC)c(Cl)c(CCc2cc(-c3nc4ccc(CN5CCN(C)CC5)cc4[nH]3)n[nH]2)c1Cl CHEMBL5177815 IC50 3.46 nM
COc1cc(OC)cc(N(CC(O)CN2CCCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3969475 pIC50 3.467 nM
CCN(CCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1)C(C)C CHEMBL3944320 pIC50 3.467 nM
COc1cc(OC)cc(N(C[C@@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3905276 pIC50 3.467 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(CN6CCOCC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681278 IC50 3.5 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccc(Cl)nn4)ccn23)c1 CHEMBL3639892 IC50 3.5 nM
Nc1cc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc(C(F)(F)F)n1 CHEMBL3690560 IC50 3.5 nM
CCOCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3906155 pIC50 3.548 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCCNCCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3973820 pIC50 3.548 nM
COc1cc(OC)cc(N(CCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3985222 pIC50 3.548 nM
COc1cc(OC)cc(N(CCCN2CCOC2=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3903198 pIC50 3.548 nM
COc1cc(OC)cc(N(CCCN2[C@H](C)CC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3902353 pIC50 3.548 nM
Cc1cc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nnc1Cl CHEMBL3690493 IC50 3.55 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(N5CCNC(C)(C)C5)cc4)n[nH]c3n2)c1Cl CHEMBL5269917 IC50 3.6 nM
COc1ccc(Cl)c(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3956571 pIC50 3.631 nM
COc1ccc(Cl)c(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3985332 pIC50 3.631 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CC(=O)NC)c3)nc2c1 CHEMBL3935232 pIC50 3.631 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CCS(C)(=O)=O)c3)nc2c1 CHEMBL3984548 pIC50 3.631 nM
CCNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3939278 pIC50 3.631 nM
COc1cc(OC)cc(N(C[C@H](O)CNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3975397 pIC50 3.631 nM
Cn1nc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)ccc1=O CHEMBL3690425 IC50 3.7 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4cc(F)ccn4)ccn23)c1 CHEMBL3690466 IC50 3.7 nM
Cn1c(CO)cnc1C#Cc1ccn2c(-c3cccc(NC(=O)NCC(F)(F)F)c3)cnc2c1 CHEMBL3694714 IC50 3.7 nM
CC(F)(F)c1cnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc1 CHEMBL3694685 IC50 3.7 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(OCC6(C)COC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3676325 IC50 3.7 nM
COc1cc(C)cc2cc(-c3c(CNC(C)=O)c(CN4CCN(C(C)=O)CC4)n4ncnc(N)c34)sc12 CHEMBL3938513 IC50 3.7 nM
COc1cc(OC)cc(N(CC#Cc2nccc(OC(C)C)n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3982718 pIC50 3.715 nM
COc1cc(OC)cc(N(CCN2CCCC2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3969815 pIC50 3.715 nM
COc1cc(OC)cc(N(CC2CO2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3974664 pIC50 3.715 nM
COc1cc(OC)cc(N(CCN2CCCCC2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3943043 pIC50 3.715 nM
COc1cc(OC)cc(N(Cc2cccs2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3911516 pIC50 3.715 nM
COc1cc(OC)cc(N(CCCN2CCCC2=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3973321 pIC50 3.715 nM
COc1cc(OC)cc(N(CCN2CCN(C)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3905048 pIC50 3.715 nM
COc1cc(OC)cc(N(Cc2nccn2S(=O)(=O)N(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3889711 pIC50 3.715 nM
CN1CCN(c2ncc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)cn2)CC1 CHEMBL3690442 IC50 3.75 nM
Cc1nc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)ccc1F CHEMBL3690524 IC50 3.75 nM
CC(O)c1cnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc1 CHEMBL3694670 IC50 3.8 nM
COc1cc(F)cc(N(CCO)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3897858 pIC50 3.802 nM
COc1cc(OCCO)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3935124 pIC50 3.802 nM
COc1cc(OC)cc(N(CCN2CCC[C@H]2C(=O)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3959201 pIC50 3.802 nM
CCOC(=O)C1CCN(CCN(c2cc(OC)cc(OC)c2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)CC1 CHEMBL3904745 pIC50 3.802 nM
CNC(=O)c1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3965640 pIC50 3.802 nM
COc1cc(OC)cc(N(CCCn2ccnc2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3969665 pIC50 3.802 nM
COc1cc(OC)cc(N(CCNCCF)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3960571 pIC50 3.802 nM
COc1cc(OC)cc(N(CC(C)NC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3945277 pIC50 3.802 nM
COc1cc(O)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907327 pIC50 3.802 nM
COc1cc(OC)cc(N(CCCNCC(F)(F)F)c2ccc3ncc(-c4cnn(CCCN)c4)nc3c2)c1 CHEMBL3892155 pIC50 3.802 nM
COC[C@@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CCCN)c3)nc2c1 CHEMBL3942506 pIC50 3.802 nM
CCN(CC)CCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3916975 pIC50 3.89 nM
COc1cc(OC)cc(N(CCN2CCNC(=O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3934355 pIC50 3.89 nM
COc1cc(C)cc2cc(-c3c(CN[C@H]4CCNC4=O)c(CN4CCOCC4)n4ncnc(N)c34)sc12 CHEMBL3905636 IC50 3.9 nM
Nc1nc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)ncc1C(F)(F)F CHEMBL3690530 IC50 3.91 nM
COc1cnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc1N CHEMBL3690525 IC50 3.93 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4nnc(C(F)(F)F)s4)ccn23)c1 CHEMBL3690382 IC50 3.96 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)csc12 CHEMBL2005631 pKi 3.981 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cn[nH]c3)nc2c1 CHEMBL3920908 pIC50 3.981 nM
COc1cc(OC)cc(N(CCN2CCC[C@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3943860 pIC50 3.981 nM
CNC(=O)c1cc(F)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3901612 pIC50 3.981 nM
COc1cc(OC)cc(N(CC2COCCN2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3919884 pIC50 3.981 nM
Nc1c(C(=O)c2cc3cc(CN4CCOCC4)ccc3[nH]2)cnn1-c1cc(O)ccc1Cl CHEMBL3984621 IC50 4.0 nM
N=C(/C=C/CN)c1ccn2c(-c3cccc(NC(=O)NCC(F)(F)F)c3)cnc2c1 CHEMBL3690374 IC50 4.0 nM
COc1cc(OC)c(Cl)c(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3986068 pIC50 4.074 nM
COc1cc(OC)cc(N(C[C@@H]2CCCN2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3979170 pIC50 4.074 nM
COc1cc(OC)cc(N(Cc2ccc(Cl)s2)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3986661 pIC50 4.074 nM
COc1cc(F)cc(N(CCO)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3981077 pIC50 4.074 nM
COc1cc(OC)cc(N(CC(O)CNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907047 pIC50 4.074 nM
COc1cc(OC)cc(N(CCN2CCC(CCO)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3973929 pIC50 4.074 nM
COc1cc(OC)cc(N(CCCN2[C@@H](C)CC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3968139 pIC50 4.074 nM
COc1cc(OC)cc(N(C[C@H](O)CNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3941695 pIC50 4.074 nM
CNC(=O)c1cc(OC)cc(N(CC(O)CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3910555 pIC50 4.074 nM
CCNS(=O)(=O)c1ccccc1Nc1ncnc(Nc2ccc(N3CCN(C)CC3)c(OCCN3CCOCC3)c2)n1 CHEMBL4645817 IC50 4.1 nM
CCNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)ncc1-c1cc(OC)cc(OC)c1 CHEMBL4635284 IC50 4.1 nM
Cc1nccc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)n1 CHEMBL3690424 IC50 4.12 nM
COc1ccnc(C#CCN(c2ccc3ncc(-c4cnn(C)c4)nc3c2)c2c(Cl)c(OC)cc(OC)c2Cl)n1 CHEMBL3953771 pIC50 4.169 nM
COc1cc(OC)cc(N(CCCN2CCC(OC)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3972517 pIC50 4.169 nM
COc1cc(OC)cc(N(CC#Cc2nccn2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3945845 pIC50 4.169 nM
CNC(=O)c1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3927733 pIC50 4.169 nM
COc1cc(OC)cc(N(CC2CCN(C)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3893070 pIC50 4.169 nM
COc1cc(OC)cc(N(CCCN2C[C@@H](C)O[C@@H](C)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3914955 pIC50 4.169 nM
CCOc1cccc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)n1 CHEMBL3690462 IC50 4.19 nM
Cc1cnnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)c1 CHEMBL3690495 IC50 4.2 nM
COc1cc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)ncn1 CHEMBL3690535 IC50 4.2 nM
CC(C)(C)OC(=O)NCC1CCN(c2ccc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)cn2)CC1 CHEMBL3694707 IC50 4.2 nM
Nc1nc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)ncc1OCCO CHEMBL3694706 IC50 4.2 nM
CNC(=O)c1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCOC)c4)nc3c2)c1 CHEMBL3931674 pIC50 4.266 nM
COc1cc(OC)c(Cl)c(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3892135 pIC50 4.266 nM
CCn1cc(-c2cnc3ccc(N(CCNC)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3893344 pIC50 4.266 nM
COc1cc(OC)cc(N(Cc2ccc(Cl)s2)c2ccc3ncc(-c4cnn(CCN5CCNCC5)c4)nc3c2)c1 CHEMBL3904441 pIC50 4.266 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3940175 pIC50 4.266 nM
COc1cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)cc2c1OCO2 CHEMBL3896142 pIC50 4.266 nM
CCN(CC)CCc1nnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)s1 CHEMBL3690594 IC50 4.3 nM
CCNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)ncc1NC(=O)c1cc(OC)cc(OC)c1 CHEMBL4642080 IC50 4.3 nM
COc1cc(Nc2ncc(CCc3c(Cl)c(OC)cc(OC)c3Cl)cn2)ccc1N1CCC(N2CCN(C)CC2)CC1 CHEMBL4750924 IC50 4.3 nM
COc1cc(OC)cc(N(CC(C)(C)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3951156 pIC50 4.365 nM
Cc1nc2ccc(-n3ncc(C(=O)c4cc5cc(CN6CCOCC6)ccc5[nH]4)c3N)cc2[nH]1 CHEMBL3891894 IC50 4.4 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(C#Cc4nccn4CCO)ccn23)c1 CHEMBL3694655 IC50 4.4 nM
O=C(NCC(F)(F)F)Nc1cc(F)cc(-c2cnc3cc(-c4ncccn4)ccn23)c1 CHEMBL3694694 IC50 4.4 nM
Cn1cncc1C#Cc1ccn2c(-c3cccc(NC(=O)NCC(F)(F)F)c3)cnc2c1 CHEMBL3690378 IC50 4.46 nM
CCOC(=O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3921313 pIC50 4.467 nM
COc1cc(OC)cc(N(CC(C)(C)O)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3915021 pIC50 4.467 nM
COc1cc(OC)cc(N(CC(O)CN2CCOCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3966560 pIC50 4.467 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4CCCO)nc3c2)c1 CHEMBL3978349 pIC50 4.467 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1C(=O)N1CCS(=O)(=O)C1 CHEMBL3977038 IC50 4.5 nM
COc1cc(OC)c(F)c(COc2cnc(Nc3cnc(N4CCC(N5CCN(C)CC5)CC4)nc3)nc2)c1F CHEMBL5189378 IC50 4.5 nM
COc1cc(OCCO)cc(N(CC2CC2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3907488 pIC50 4.571 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CCN(C)CC5)c4)nc3c2)c1 CHEMBL3917908 pIC50 4.571 nM
COc1cc(OC)cc(N(C[C@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3969414 pIC50 4.571 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C(C)CN)c1 CHEMBL3976752 pIC50 4.571 nM
COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3ccccc3)n2)c1Cl CHEMBL5203040 IC50 4.58 nM
Cn1cc(C#Cc2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)cn1 CHEMBL3690419 IC50 4.6 nM
Cn1cncc1/C=C/c1ccn2c(-c3cccc(NC(=O)NCC(F)(F)F)c3)cnc2c1 CHEMBL3690508 IC50 4.6 nM
CCOC(=O)c1cnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc1N CHEMBL3694679 IC50 4.6 nM
CNC(=O)c1cccc(-c2cnc3cc(-c4cnn(C)c4)c(OC)nn23)c1 CHEMBL5201556 IC50 4.6 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CC(=O)NC)c3)nc2c1 CHEMBL3909140 pIC50 4.677 nM
COc1cc(OC)cc(N(CCN2CCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3890607 pIC50 4.677 nM
COc1cc(C)cc2cc(-c3c(COCCO)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3895503 IC50 4.7 nM
Cc1nsc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)n1 CHEMBL3647346 IC50 4.74 nM
O=C1CN(c2ncc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)cn2)CCN1 CHEMBL3690457 IC50 4.75 nM
COc1cc(OC)cc(N(CCN2C(C)CCCC2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3920007 pIC50 4.786 nM
COc1cc(OC)cc(N(CCN2CCCC(C#N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3973587 pIC50 4.786 nM
COc1cc(OC)cc(N(CCCN2CCS(=O)(=O)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3925077 pIC50 4.786 nM
COc1cc(OC)cc(N(C[C@@H](O)CN2CC[C@H](C#N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3967065 pIC50 4.786 nM
COc1cc(F)cc(N(CCCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3951360 pIC50 4.786 nM
COc1cc(OC)cc(N(CC#Cc2ccncc2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3897523 pIC50 4.786 nM
Cn1ccnc1C#Cc1ccn2c(-c3cccc(NC(=O)NCC(F)(F)F)c3)cnc2c1 CHEMBL3694674 IC50 4.8 nM
COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3cnn(C4CCN(C(C)C)CC4)c3)n2)c1Cl CHEMBL5193966 IC50 4.8 nM
Nc1nc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)ncc1F CHEMBL3690465 IC50 4.82 nM
Nc1cnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)cn1 CHEMBL3690448 IC50 4.89 nM
NC(=O)Nc1cccc(-c2cnc3cc(-c4nncs4)ccn23)c1 CHEMBL3694661 IC50 4.89 nM
CCOc1cc(F)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3962549 pIC50 4.898 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCNC(C)C)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3909551 pIC50 4.898 nM
COc1cc(OC)c(F)c(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1F CHEMBL3954396 pIC50 4.898 nM
COc1cc(C)cc2cc(-c3c(COC4CCC4)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3979384 IC50 4.9 nM
COc1cc(C)cc2cc(-c3c(CNCCO)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3905236 IC50 4.9 nM
C=CC(=O)Nc1ccc(/C=C/c2nc(Nc3cn(C(C)C)cn3)cc(N3CCN(C)CC3)n2)cc1 CHEMBL4760839 GI50 4.9 nM
Cc1ncc(C#Cc2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)n1C CHEMBL3690427 IC50 4.95 nM
COc1cc(CCc2cc(Nc3ncnc4cc(N5CCN6CCCCC6C5)ccc34)n[nH]2)cc(OC)c1 CHEMBL3800526 IC50 5.0 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 5.012 nM
Cc1cc2cc(-c3csc4c(-c5cccc(S(C)(=O)=O)c5)cnc(N)c34)ccc2[nH]1 CHEMBL1997822 pKi 5.012 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCN)c4)nc3c2)c1 CHEMBL3956164 pIC50 5.012 nM
COc1cc(OC)cc(N(CCCN2[C@H](C)CC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3927451 pIC50 5.012 nM
COc1cc(OC)cc(N(CC#Cc2ccnc(N)n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3964043 pIC50 5.012 nM
COc1cc(OC)cc(N(CCN(C)C(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3908707 pIC50 5.012 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(F)cc4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4092508 IC50 5.07 nM
COc1ccc(Nc2ncc3c(n2)N(C2CCN(C(=O)/C=C/CN(C)C)CC2)C(=O)N(c2c(Cl)c(OC)cc(OC)c2Cl)C3)cc1 CHEMBL4100258 IC50 5.09 nM
O=C(NCC(F)(F)F)Nc1cc(F)cc(-c2cnc3cc(-c4ccnc(C(F)(F)F)n4)ccn23)c1 CHEMBL3694647 IC50 5.1 nM
CNCCn1cc(-c2cnc3ccc(N(CC4CC4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3931381 pIC50 5.129 nM
COc1cc(OC)cc(N(CC2OCCO2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3901644 pIC50 5.129 nM
COc1cc(OC)cc(N(CCCN2CCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3973263 pIC50 5.129 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)[C@H](C)CN)c1 CHEMBL3957414 pIC50 5.129 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)[C@@H](C)CN)c1 CHEMBL3922607 pIC50 5.129 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4C)nc3c2)c1 CHEMBL3966071 pIC50 5.129 nM
Nc1cnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc1N CHEMBL3694702 IC50 5.2 nM
CC(=O)c1cnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc1 CHEMBL3694684 IC50 5.2 nM
COc1cc(C)cc2cc(-c3c(COCC4CC4)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3909132 IC50 5.2 nM
C=CC(=O)N1CCC(c2ccc(-c3nc(Nc4cc(C)[nH]n4)cc(N4CCN(C)CC4)n3)cc2)C1 CHEMBL4765110 GI50 5.2 nM
COc1cc(CCc2cnc(Nc3ccc(N4CCC(N5CCN(C)CC5)CC4)c(OC)c3)nc2)c(F)c(OC)c1 CHEMBL4791437 IC50 5.2 nM
COc1cc(OC)cc(N(CCCN2CCC(N3C[C@@H](C)O[C@@H](C)C3)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3961400 pIC50 5.248 nM
COc1cc(OC)cc(N(CCCN2CCCC2(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3968818 pIC50 5.248 nM
COc1cc(OC)cc(N(CCCNCC(F)(F)F)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3911738 pIC50 5.248 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C(C)CNC(C)C)c1 CHEMBL3942606 pIC50 5.248 nM
COc1cc(OC)cc(N(CC(C)NCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3959260 pIC50 5.248 nM
COc1cc(OC)cc(N(CCCNCC(F)(F)F)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3952866 pIC50 5.248 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1C(=O)N1CNC(=O)C1 CHEMBL3934358 IC50 5.3 nM
COc1ccc(Cl)c(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3969824 pIC50 5.37 nM
COc1cc(OC)cc(N(CCNCC2CCCO2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3896623 pIC50 5.37 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C(C)C(N)=O)c1 CHEMBL3890118 pIC50 5.37 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4096041 IC50 5.38 nM
Nc1nc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)ncc1CO CHEMBL3694720 IC50 5.4 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(OCCN6CCOCC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3676315 IC50 5.4 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(CN6CCOC[C@@H]6C)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3676328 IC50 5.4 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(CCO)CC5)cc4)c3)c(OCCOC)cc21 CHEMBL3686884 IC50 5.4 nM
COc1cc(C)cc2cc(-c3c(CN4CCNC(=O)C4)c(C#N)n4ncnc(N)c34)sc12 CHEMBL3897839 IC50 5.4 nM
COc1cc(OC)cc(N(CCNC2CCN(S(N)(=O)=O)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3917295 pIC50 5.495 nM
Nc1nc(-c2ccn3c(-c4cc(Cl)cc(NC(=O)NCC(F)(F)F)c4)cnc3c2)ncc1F CHEMBL3694692 IC50 5.5 nM
C=CC(=O)N1CCC(c2cc3c(Oc4ccc(NC(=O)NC5CC5)c(Cl)c4)ccnc3cc2OCC)CC1 CHEMBL5436527 IC50 5.5 nM
COc1cc(CCc2cc(-c3nc4ccc(N5CCOCC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5207255 IC50 5.51 nM
COCc1cc(N)nc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)n1 CHEMBL3694713 IC50 5.6 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5c(NC(CO)CO)cccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681282 IC50 5.6 nM
CN1CC2CCC(C1=O)C2c1ncc2[nH]nc(-c3cnn(C)c3)c2n1 CHEMBL5290074 IC50 5.6 nM
CCOC(=O)Cn1cc(CN(c2cc(OC)cc(OC)c2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)nn1 CHEMBL3904777 pIC50 5.623 nM
COc1cc(OC)cc(N(CCN2CCC(N)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3893718 pIC50 5.623 nM
COc1cc(OC)cc(N(CCN2C[C@@H]3C[C@H]2CN3)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3940672 pIC50 5.623 nM
COc1cc(OC)cc(N(CC#Cc2cc(N)nc(C)n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3982399 pIC50 5.623 nM
CCCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCNCC1 CHEMBL3907995 IC50 5.7 nM
COc1cc(OC)cc(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1 CHEMBL4856613 IC50 5.7 nM
COc1cc(F)cc(N(CCCN2CCC(C#N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3942811 pIC50 5.754 nM
COc1cc(OC)cc(N(CCN2CCN(CCO)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3983529 pIC50 5.754 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)[C@H]2CC[C@H](NC(C)C)CC2)c1 CHEMBL3918800 pIC50 5.754 nM
NC(=O)Nc1cccc(-c2cnc3cc(-c4ncc(F)c(N)n4)ccn23)c1 CHEMBL3690519 IC50 5.76 nM
Cc1cnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc1N CHEMBL3690527 IC50 5.83 nM
COc1cccnc1C#CCN(c1ccc2ncc(-c3cnn(C)c3)nc2c1)c1c(Cl)c(OC)cc(OC)c1Cl CHEMBL3969667 pIC50 5.888 nM
COc1cc(OC)cc(N(CC2CCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3926406 pIC50 5.888 nM
COc1cc(OC)cc(N(CC2CCOCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3956120 pIC50 5.888 nM
COc1cc(OC)cc(N(CCN2CCCC(N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3957533 pIC50 5.888 nM
COc1cc(OC)c(C)c(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3945264 pIC50 5.888 nM
COc1cc(O)cc(N(CCN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3903823 pIC50 5.888 nM
COc1ncc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)cc1C CHEMBL3690539 IC50 5.9 nM
CN1CC2CCC(C1=O)N2c1ncc2[nH]nc(-c3cnn(C4CC4)c3)c2n1 CHEMBL5284555 IC50 5.9 nM
C=CC(=O)Nc1cccc(CN2C(=O)N(c3c(Cl)c(OC)cc(OC)c3Cl)Cc3cnc(NCCCCN(CC)CC)nc32)c1 CHEMBL2216830 IC50 5.99 nM
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(C)CC5)cc4)c3)c(OCCOC)cc21 CHEMBL3686883 IC50 6.0 nM
Cn1cc(-c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)cn1 CHEMBL3964954 IC50 6.0 nM
COC/C(CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1)=N/O CHEMBL3892632 pIC50 6.026 nM
COc1cc(OC)cc(N(CCN2CCC(C(C)(C)O)CC2)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3969112 pIC50 6.026 nM
COc1cc(OC)cc(N(CCNC[Si](C)(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3893950 pIC50 6.026 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4nnc(CCN5CCCC5)s4)ccn23)c1 CHEMBL3690589 IC50 6.1 nM
COc1cc(C)cc2cc(-c3c(CNC4CCC4)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3969060 IC50 6.1 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(CC#Cc2ccncc2)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3943917 pIC50 6.166 nM
COc1cc(OC)cc(N(CCN2C[C@H](C)C[C@@H](C)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3957643 pIC50 6.166 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CC(C)(C)O)c4)nc3c2)c1 CHEMBL3915235 pIC50 6.166 nM
COc1cc(OC)cc(N(CC2CN(Cc3ccccc3)CCO2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3925610 pIC50 6.166 nM
COc1cc(OC)cc(N(CC#CC2(O)CNC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3922100 pIC50 6.166 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4c[nH]c(=O)cn4)ccn23)c1 CHEMBL3690468 IC50 6.2 nM
Cn1ccc(C#Cc2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)n1 CHEMBL3690449 IC50 6.28 nM
Cc1ccc(-c2ccn3c(-c4cncc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nn1 CHEMBL3690386 IC50 6.29 nM
COc1cccc(N(Cc2cc(C)no2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3947990 pIC50 6.31 nM
C=CCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3950262 pIC50 6.31 nM
COc1cc(OCCF)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3946674 pIC50 6.31 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CC4CCOCC4)c3)nc2c1 CHEMBL3932363 pIC50 6.31 nM
Nc1ccnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)n1 CHEMBL3690473 IC50 6.35 nM
COc1cc(C)cc2cc(-c3c(COCCN)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3958993 IC50 6.4 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 6.42 nM
COc1cc(OC)cc(N(CCN2CCC(C(C)(C)O)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3931154 pIC50 6.457 nM
COc1cc(OC)cc(N(CCNCCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3895443 pIC50 6.457 nM
COc1cc(OC)cc(N(CC#Cc2ncccc2N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3906938 pIC50 6.457 nM
Cc1nc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)cc(N2CCN(CCO)CC2)n1 CHEMBL3690545 IC50 6.5 nM
COc1cc(OCCO)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3909318 pIC50 6.607 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCF)c4)nc3c2)c1 CHEMBL3971073 pIC50 6.607 nM
COc1cc(Cl)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3965614 pIC50 6.607 nM
COc1cc(OC)cc(N(CCCN2CCC(F)(F)C2)c2ccc3ncc(-c4cnn(CC5CCOCC5)c4)nc3c2)c1 CHEMBL3924422 pIC50 6.607 nM
COc1cc(OC)cc(N(CCN2[C@@H](C)CC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3932756 pIC50 6.607 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(OC6CCOCC6)cc5[nH]4)c3N)ccc2[nH]1 CHEMBL3676316 IC50 6.7 nM
COc1cc(OCCF)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3959193 pIC50 6.761 nM
COc1cc(C)cc2cc(-c3c(CNCC(C)(C)O)c(CN4CCOCC4)n4ncnc(N)c34)sc12 CHEMBL3957859 IC50 6.8 nM
COc1cc(C)cc2cc(-c3c(CN4CCNC(=O)C4)c(CN4CCN(C(C)=O)CC4)n4ncnc(N)c34)sc12 CHEMBL3954561 IC50 6.8 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CO CHEMBL3953385 IC50 6.8 nM
C=CC(=O)N1CCC2(CCN(c3nc(Nc4cc(C(C)C)[nH]n4)cc(N4CCN(C)CC4)n3)CC2)C1 CHEMBL4779534 GI50 6.9 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(N5CCN(CCO)CC5)cc4)c3)ccc12 CHEMBL4278642 IC50 6.9 nM
Nc1nc(-c2ccn3c(-c4cncc(NC(=O)NCC(F)(F)F)c4)cnc3c2)ncc1F CHEMBL3690520 IC50 6.97 nM
CCN1CCC(c2ccc(Nc3cc(N(C)C(=O)Nc4c(Cl)c(OC)cc(OC)c4Cl)ncn3)cc2)CC1 CHEMBL1834661 IC50 7.0 nM
COc1cc(OC)c(F)c(-c2ccc(C(=O)Nc3ncc(CN4CCCC4)[nH]3)c3nccnc23)c1F CHEMBL3653133 IC50 7.0 nM
COc1cc(OC)c(Cl)c(-c2ccc(C(=O)Nc3ccc(CN4CCN(C)CC4)cn3)c3nccnc23)c1F CHEMBL3653123 IC50 7.0 nM
COc1cc(C)cc2cc(-c3c(CN4CCNC(=O)C4)c(CN4CCOCC4)n4ncnc(N)c34)sc12 CHEMBL3921263 IC50 7.0 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4cccc(F)c4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4079538 IC50 7.04 nM
COc1cc(OC)cc(N(CC2(O)CCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3968361 pIC50 7.079 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3909951 pIC50 7.079 nM
COc1cc(OC)cc(N(CCN2CCCNCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3982107 pIC50 7.079 nM
CCc1c(-c2cnc3ccc(N(CCNC(C)C)c4cc(OC)cc(OC)c4)cc3n2)cnn1C CHEMBL3918426 pIC50 7.079 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1C(=O)N[C@@H]1CCNC1=O CHEMBL4112606 IC50 7.1 nM
COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4cccc(C)c4)nc3N(C3CCN(C(=O)/C=C/CN(C)C)CC3)C2=O)c1Cl CHEMBL4103795 IC50 7.12 nM
COc1cccc(Nc2ncc3c(n2)N(C2CCN(C(=O)/C=C/CN(C)C)CC2)C(=O)N(c2c(Cl)c(OC)cc(OC)c2Cl)C3)c1 CHEMBL4068733 IC50 7.15 nM
COc1cc(C)cc2cc(-c3c(COCC(N)=O)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3926373 IC50 7.2 nM
COc1cc(C)cc2cc(-c3c(CN4CCC(O)CC4)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3906882 IC50 7.2 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCN)c4)nc3c2)c1 CHEMBL3921817 pIC50 7.244 nM
O=C(NCC(F)(F)F)Nc1cncc(-c2cnc3cc(-c4cccnn4)ccn23)c1 CHEMBL3690385 IC50 7.36 nM
Nc1nc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)cc(C(F)(F)F)n1 CHEMBL3690593 IC50 7.4 nM
COc1cc(OC)cc(N(CC2CCCO2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3940334 pIC50 7.413 nM
COc1cc(OC)cc(N(CCCN2CCC(F)(F)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3950907 pIC50 7.413 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CCO)c3)nc2c1 CHEMBL3893373 pIC50 7.413 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCN5CCN(CCCO)CC5)c4)nc3c2)c1 CHEMBL3951171 pIC50 7.413 nM
NC(=O)c1ccnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)n1 CHEMBL3690537 IC50 7.56 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(CCCNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3927219 pIC50 7.586 nM
CNc1ncc2c(n1)N(C1CCN(C(=O)/C=C/CN(C)C)CC1)C(=O)N(c1c(Cl)c(OC)cc(OC)c1Cl)C2 CHEMBL4092354 IC50 7.59 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(/C=C/CO)ccn23)c1 CHEMBL3690556 IC50 7.7 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1C(=O)NCCO CHEMBL3949665 IC50 7.7 nM
CCn1cc(-c2n[nH]c3cnc(C4C5CCC4C(=O)N(C)C5)nc23)cn1 CHEMBL5268285 IC50 7.7 nM
CN1CCC(O)(C#Cc2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)CC1 CHEMBL3690428 IC50 7.74 nM
COc1cc(OC)cc(N(CCCn2c(C)cnc2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3911746 pIC50 7.762 nM
COc1cc(OC)cc(N(Cc2cc3ncccc3o2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3905633 pIC50 7.762 nM
COc1cnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc1 CHEMBL3690496 IC50 7.86 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccnnc4)ccn23)c1 CHEMBL3690451 IC50 7.87 nM
CCN1CCC(c2ccc(C(=O)Nc3cc(Oc4cc5ccn(C(=O)NC)c5cc4OC)ccn3)cc2)CC1 CHEMBL3686864 IC50 7.9 nM
COc1cc(C)cc2cc(-c3c(CN4CCCC(O)C4)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3929725 IC50 7.9 nM
NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)NCCCCN1CCCC1 CHEMBL253969 pKi 7.943 nM
CNC(=O)c1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3901420 pIC50 7.943 nM
COc1cc(OC)cc(N(CC2(OC)CCCNC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3891474 pIC50 7.943 nM
CNCCN(c1cc(F)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3891464 pIC50 7.943 nM
COc1cc(OC)cc(N(CC#Cc2nccs2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3977708 pIC50 7.943 nM
O=C(NCC(F)(F)F)Nc1cncc(-c2cnc3cc(-c4nncs4)ccn23)c1 CHEMBL3690389 IC50 8.0 nM
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3ccccc3O)cc12 CHEMBL4073545 IC50 8.0 nM
C=CC(=O)N1CC2(CCN(c3nc(Nc4cc(C(C)C)[nH]n4)cc(N4CCN(C)CC4)n3)CC2)C1 CHEMBL4783883 GI50 8.0 nM
COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)c1Cl CHEMBL5185122 IC50 8.05 nM
COc1cc(CCc2cc(-c3nc4cc(F)c(N5CCN(C)CC5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5189958 IC50 8.07 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ncc(C(=O)O)cn4)ccn23)c1 CHEMBL3694721 IC50 8.1 nM
COc1cc(C)cc2cc(-c3c(CNC4CC4)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3930377 IC50 8.1 nM
CCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3890126 pIC50 8.128 nM
COc1cc(OC)cc(N(C[C@H](C)N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3895378 pIC50 8.128 nM
Cn1cncc1C#Cc1ccn2c(-c3cc(NC(=O)NCC(F)(F)F)ccc3F)cnc2c1 CHEMBL3694716 IC50 8.2 nM
O=C(NCC(F)(F)F)Nc1cc(Cl)cc(-c2cnc3cc(-c4ncccn4)ccn23)c1 CHEMBL3694699 IC50 8.2 nM
COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3ccc(N4CCC(O)CC4)cc3)n2)c1Cl CHEMBL5190994 IC50 8.29 nM
COc1cnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)cn1 CHEMBL3690452 IC50 8.3 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCOCC1 CHEMBL3969781 IC50 8.3 nM
COc1cc(OC)cc(N(CCCNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3968793 pIC50 8.318 nM
Cc1nc2cc(-n3ncc(C(=O)c4cc5cc(C(=O)O)ccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3681295 IC50 8.4 nM
COC(=O)c1cnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nc1 CHEMBL3694682 IC50 8.5 nM
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(C5CCN(S(C)(=O)=O)CC5)c4)nc3c2)c1 CHEMBL3918011 pIC50 8.511 nM
COc1cc(OC)cc(N(CCn2cccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921243 pIC50 8.511 nM
COc1ccc(Cl)c(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3983387 pIC50 8.511 nM
CCc1c(-c2cnc3ccc(N(CCO)c4cc(OC)cc(OC)c4)cc3n2)cnn1C CHEMBL3986725 pIC50 8.511 nM
COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3ccc(N4CCOCC4)nc3)n2)c1Cl CHEMBL5206623 IC50 8.62 nM
CC(C)n1ccnc1C#Cc1ccn2c(-c3cccc(NC(=O)NCC(F)(F)F)c3)cnc2c1 CHEMBL3694659 IC50 8.66 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN[C@H]1CCNC1=O CHEMBL3938754 IC50 8.7 nM
CCOc1cc(F)cc(N(CCN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3930819 pIC50 8.71 nM
COc1cc(OC)cc(N(CCN2CCOC2=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3930158 pIC50 8.913 nM
COc1cc(OC)cc(N(Cc2cccc(Br)n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3940940 pIC50 8.913 nM
COc1cc(OC)cc(N(Cc2nccn2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3927585 pIC50 8.913 nM
COc1cc(O)cc(N(CCCNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3935177 pIC50 8.913 nM
COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cccc(N4CCN(C)CC4)c3)ncn2)c1Cl CHEMBL1834658 IC50 9.0 nM
COc1cc(OC)c(Cl)c(-c2ccc(C(=O)Nc3ncc(CN4CCN(C)CC4)[nH]3)c3nccnc23)c1F CHEMBL3653138 IC50 9.0 nM
COc1cc(OC)c(F)c(-c2ccc(C(=O)Nc3ncc(CN(C)C)[nH]3)c3ncccc23)c1F CHEMBL3653141 IC50 9.0 nM
Cc1cnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)cn1 CHEMBL3690456 IC50 9.04 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4nccc(N5CCN(CCO)CC5)n4)ccn23)c1 CHEMBL3694663 IC50 9.1 nM
COc1cc(OC)cc(N(CC#Cc2cc(C#N)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3952789 pIC50 9.12 nM
CNC(=O)c1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3929648 pIC50 9.12 nM
COc1cc(OC)cc(N(CCN2C[C@@H](C)O[C@@H](C)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3951728 pIC50 9.12 nM
CNC(=O)c1cc(F)cc(N(CC(C)(C)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3951090 pIC50 9.12 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C([2H])([2H])C([2H])([2H])C([2H])([2H])NCC(F)(F)F)c1 CHEMBL3966929 pIC50 9.12 nM
Cc1cc(N)nc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)n1 CHEMBL3690523 IC50 9.2 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4cnccn4)ccn23)c1 CHEMBL3690395 IC50 9.26 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccnc(C(F)(F)F)n4)ccn23)c1 CHEMBL3690549 IC50 9.28 nM
C=CC(=O)N1CC(c2ccc(-c3nc(Nc4cc(C)[nH]n4)cc(N4CCN(C)CC4)n3)cc2)C1 CHEMBL4746615 GI50 9.3 nM
COc1cc(OC)cc(N(CC#Cc2cc(C)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3983694 pIC50 9.333 nM
COc1cc(OC)cc(N(CC#Cc2ncccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3975193 pIC50 9.333 nM
COc1cc(OC)cc(N(Cc2ncccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3901265 pIC50 9.333 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ncc(CO)cn4)ccn23)c1 CHEMBL3694668 IC50 9.4 nM
COCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCN(C(C)=O)CC1 CHEMBL3915403 IC50 9.4 nM
COc1cc(C)cc2cc(-c3c(CNC(C)=O)c(CN4CCNC(=O)C4)n4ncnc(N)c34)sc12 CHEMBL3976573 IC50 9.4 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 IC50 9.4 nM
C=CC(=O)N1CC[C@H](n2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnc32)C1 CHEMBL4475243 IC50 9.4 nM
COc1ccnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)n1 CHEMBL3694723 IC50 9.44 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4cc(=O)[nH]cn4)ccn23)c1 CHEMBL3690536 IC50 9.5 nM
CCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1C(=O)N(C)C CHEMBL3969794 IC50 9.6 nM
Cn1cncc1C#Cc1ccn2c(-c3cccc(NC(N)=O)c3)cnc2c1 CHEMBL3694660 IC50 9.65 nM
COCCOCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCNCC1 CHEMBL3984301 IC50 9.7 nM
COc1cc(C)cc2cc(-c3c(CN4CCCC4)c(CN4CCNCC4)n4ncnc(N)c34)sc12 CHEMBL3907380 IC50 9.7 nM
COc1cc(CCc2cc(-c3nc4ccc(N5C[C@@H](C)O[C@@H](C)C5)cc4[nH]3)n[nH]2)cc(OC)c1 CHEMBL5173892 IC50 9.7 nM
COc1cc(OC)cc(N(CCN2CCC(F)(F)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3934039 pIC50 9.772 nM
COc1cc(F)cc(N(CCN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3975714 pIC50 9.772 nM
CNC(=O)c1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907063 pIC50 9.772 nM
[2H]C([2H])([2H])Oc1cc(F)cc(N(CCN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3955745 pIC50 9.772 nM
COc1cc(OC)cc(N(Cc2cc(C)n(C)n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3953117 pIC50 9.772 nM
COc1cc(OC)c(Cl)c(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1Cl CHEMBL3979328 pIC50 9.772 nM
CNCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCNCC1 CHEMBL3948716 IC50 9.8 nM
COc1cc(C)cc2cc(-c3c(CN4CCNC(=O)C4)c(CN4CCN(C=O)CC4)n4ncnc(N)c34)sc12 CHEMBL3974164 IC50 9.8 nM
COc1cccc(Nc2ncnc(-c3cccnc3Nc3c(Cl)c(OC)cc(OC)c3Cl)n2)c1 CHEMBL5188557 IC50 9.81 nM