COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCSCC4=O)c(C=O)nc32)ncc1C#N CHEMBL3948579 IC50 0.1 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(NC(=O)N2CCCc3ccc(C=O)nc32)ncc1Cl CHEMBL3912731 IC50 0.2 nM
COC[C@@H](C)Oc1cc(NC(=O)N2CCCc3cc(CN4C(=O)OC[C@@H]4C)c(C=O)nc32)ncc1C#N CHEMBL3968338 IC50 0.2 nM
COCCNc1cc(NC(=O)N2CCCc3cc(N4CCOC4=O)c(C=O)nc32)ncc1C#N CHEMBL3912896 IC50 0.2 nM
COCCOc1cc(NC(=O)N2CCCc3cc(CN4C[C@H](N(C)C)CC4=O)c(C=O)nc32)ncc1C#N CHEMBL4786195 IC50 0.2 nM
C=CC(=O)Nc1cc(N2CCC(N3CCOCC3)CC2)cc(F)c1Nc1n[nH]c2ccc(O[C@H](C)c3c(Cl)cncc3Cl)cc12 CHEMBL5194425 IC50 0.25 nM
N#Cc1cnc(NC(=O)N2CCCc3ccc(C=O)nc32)cc1OCC1CCO1 CHEMBL3915180 IC50 0.3 nM
COCCNc1cc(NC(=O)N2CCCc3cc(CN4C(=O)COC[C@@H]4C)c(C=O)nc32)ncc1C#N CHEMBL3938786 IC50 0.3 nM
CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)CO)c(C=O)nc32)ncc1C#N CHEMBL3924363 IC50 0.3 nM
COCCNc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)COC)c(C=O)nc32)ncc1C#N CHEMBL3946444 IC50 0.3 nM
COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCOCC4=O)c(C=O)nc32)ncc1C#N CHEMBL3968334 IC50 0.4 nM
CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)CN(C)C)c(C=O)nc32)ncc1C#N CHEMBL3975745 IC50 0.4 nM
CC(=O)N(C)Cc1cc2c(nc1C=O)N(C(=O)Nc1cc(NCCOC(F)(F)F)c(C#N)cn1)CCC2 CHEMBL3922033 IC50 0.4 nM
C=CC(=O)Nc1cccc(C)c1Nc1cc(-c2cccnc2Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 CHEMBL4744686 IC50 0.4 nM
CC(=O)N(C)Cc1cc2c(nc1C=O)N(C(=O)Nc1cc(NC(C)C)c(C#N)cn1)CCC2 CHEMBL4796410 IC50 0.4 nM
COc1cc(OC)c(F)c(COc2cnc(Nc3cnn(CCO)c3)nc2)c1F CHEMBL4594428 IC50 0.47 nM
C#CC(=O)N1CC[C@H](n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701239 IC50 0.5 nM
C=CC(=O)Nc1cc(CCN2CCN(C)CC2)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4866267 IC50 0.55 nM
COCCNc1cc(NC(=O)N2CCCc3cc(CN4C(=O)COC[C@H]4C)c(C=O)nc32)ncc1C#N CHEMBL4110949 IC50 0.6 nM
COC[C@@H](C)Oc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc32)ncc1C#N CHEMBL4111721 IC50 0.6 nM
COCCNc1cc(NC(=O)N2c3nc(C=O)c(CN4CCN(C)CC4=O)cc3CC[C@@H]2C)ncc1C#N CHEMBL3955196 IC50 0.6 nM
COCCOc1cc(NC(=O)N2CCCc3cc(CN4C[C@@H](N(C)C)CC4=O)c(C=O)nc32)ncc1C#N CHEMBL4754106 IC50 0.6 nM
CC(C)Oc1cc(NC(=O)N2CCCc3ccc(C=O)nc32)ncc1C#N CHEMBL3973588 IC50 0.7 nM
N#Cc1cnc(NC(=O)N2CCCc3ccc(C=O)nc32)cc1OC1CCOC1 CHEMBL3959971 IC50 0.7 nM
CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc32)ncc1C#N CHEMBL3924265 IC50 0.7 nM
CC(C)Nc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc32)ncc1C#N CHEMBL3948578 IC50 0.7 nM
CC(C)Oc1cc(NC(=O)N2c3nc(C=O)c(CN4CCN(C)CC4=O)cc3CC[C@@H]2C)ncc1C#N CHEMBL3940110 IC50 0.7 nM
CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN4CCCC4=O)c(C=O)nc32)ncc1C#N CHEMBL4764394 IC50 0.7 nM
C=CC(=O)Nc1cccc(OC)c1Nc1cc2c(cn1)cc(-c1c(Cl)c(OC)cc(OC)c1Cl)c(=O)n2CC CHEMBL5202677 IC50 0.7 nM
C=CC(=O)N[C@H]1CCOC[C@H]1Nc1cc2c(cn1)cc(-c1c(Cl)c(OC)cc(OC)c1Cl)c(=O)n2CC CHEMBL5186034 IC50 0.7 nM
N#Cc1cnc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)cc1OCC(O)CCCl CHEMBL3927056 IC50 0.8 nM
N#Cc1cnc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)cc1N[C@@H]1[C@H]2CC[C@H](C2)[C@@H]1CO CHEMBL4115011 IC50 0.8 nM
COCCNc1cc(NC(=O)N2CCCc3cc(CN4CC[C@@H](O)C4=O)c(C=O)nc32)ncc1C#N CHEMBL4107472 IC50 0.8 nM
C=CC(=O)Nc1ccccc1C(=O)Nc1cc(CCc2cc(OC)cc(OC)c2)[nH]n1 CHEMBL4284069 IC50 0.8 nM
CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN(C)S(C)(=O)=O)c(C=O)nc32)ncc1C#N CHEMBL4758832 IC50 0.8 nM
CCN1CCN(c2ccc(Nc3cc(N(C)C(=O)Nc4c(Cl)c(OC)cc(OC)c4Cl)ncn3)cc2)CC1 CHEMBL1852688 IC50 0.82 nM
COCCNc1cc(NC(=O)N2CCCc3cc(CN4CC[C@H](O)C4=O)c(C=O)nc32)ncc1C#N CHEMBL3935951 IC50 0.9 nM
COCCNc1cc(NC(=O)N2CCCc3cc(C(F)F)c(C=O)nc32)ncc1C#N CHEMBL4742811 IC50 0.9 nM
CCN(Cc1cc2c(nc1C=O)N(C(=O)Nc1cc(NCCOC)c(C#N)cn1)CCC2)C(C)=O CHEMBL4745780 IC50 0.9 nM
COCCOc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)CN(C)C)c(C=O)nc32)ncc1C#N CHEMBL4791610 IC50 0.9 nM
COCCOc1cc(NC(=O)N2CCCc3cc(CN4CC[C@H](N(C)C)C4=O)c(C=O)nc32)ncc1C#N CHEMBL4745615 IC50 0.9 nM
COCCOc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc32)ncc1C#N CHEMBL3973674 IC50 0.9 nM
CC(C)Oc1cc(NC(=O)N2CCCc3cc(C4CCOC4)c(C=O)nc32)ncc1C#N CHEMBL3940039 IC50 1.0 nM
CO[C@@H]1CCN(Cc2cc3c(nc2C=O)N(C(=O)Nc2cc(N[C@@H]4CCOC4)c(C#N)cn2)CCC3)C1=O CHEMBL4457168 IC50 1.0 nM
CO[C@@H]1CCC[C@H]1Nc1cc(NC(=O)N2CCCc3cc(CN4CCOCC4=O)c(C=O)nc32)ncc1C#N CHEMBL4439119 IC50 1.0 nM
C=CC(=O)Nc1cc(CCN(CC)CCC)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4856555 IC50 1.0 nM
C=CC(=O)Nc1cc(CCN2CCCC2CN2CCCC2)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4866362 IC50 1.0 nM
N#Cc1cnc(NC(=O)N2CCCc3ccc(C=O)nc32)cc1OCC1CCCO1 CHEMBL3891494 IC50 1.1 nM
CC(C)Oc1cc(NC(=O)N2CCc3ccc(C=O)nc32)ncc1C#N CHEMBL3896282 IC50 1.1 nM
COCCNc1cc(NC(=O)N2CCCc3cc(-n4ccnc4)c(C=O)nc32)ncc1C#N CHEMBL3945836 IC50 1.1 nM
CC(=O)N(Cc1cc2c(nc1C=O)N(C(=O)Nc1cc(OC(C)C)c(C#N)cn1)CCC2)C(C)C CHEMBL4756889 IC50 1.1 nM
C=CC(=O)Nc1cc(CCN2CCN(CCOC)CC2)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4864145 IC50 1.1 nM
C=CC(=O)Nc1cc(CCN2CCN(C3COC3)CC2)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4848448 IC50 1.1 nM
C=CC(=O)Nc1cccc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4068896 IC50 1.16 nM
CC1(O)CCN(c2cc(NC(=O)N3CCCc4ccc(C=O)nc43)ncc2C#N)CC1 CHEMBL3940572 IC50 1.2 nM
N#Cc1cnc(NC(=O)N2CCCc3ccc(C=O)nc32)cc1OCC1CCCCO1 CHEMBL3951896 IC50 1.2 nM
COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCS(=O)(=O)CC4=O)c(C=O)nc32)ncc1C#N CHEMBL3904238 IC50 1.2 nM
CN1CCN(Cc2cc3c(nc2C=O)N(C(=O)Nc2cc(NCCO)c(C#N)cn2)CCC3)C(=O)C1 CHEMBL3978835 IC50 1.2 nM
COCCNc1cc(NC(=O)N2CCCc3cc(C4CCN(CC(F)F)CC4)c(C=O)nc32)ncc1C#N CHEMBL3913839 IC50 1.2 nM
COCCNc1cc(NC(=O)N2CCCc3cc(CN4CC[C@@H](OC)C4=O)c(C=O)nc32)ncc1C#N CHEMBL4518346 IC50 1.2 nM
COCCNc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)C(C)C)c(C=O)nc32)ncc1C#N CHEMBL4784921 IC50 1.2 nM
COCCOc1cc(NC(=O)N2CCCc3cc(C4CCN(CC(F)(F)F)CC4)c(C=O)nc32)ncc1C#N CHEMBL4764678 IC50 1.2 nM
COc1cc(OC)cc(N(CCNS(C)(=O)=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921618 pIC50 1.23 nM
COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc32)ncc1C#N CHEMBL3908979 IC50 1.26 nM
COCCOc1cc(NC(=O)N2CCCc3ccc(C=O)nc32)ncc1C#N CHEMBL3908044 IC50 1.3 nM
N#Cc1cnc(NC(=O)N2CCCc3cc(CN4CCCCOC4=O)c(C=O)nc32)cc1N[C@@H]1CCOC1 CHEMBL4562284 IC50 1.3 nM
COC[C@@H](C)Oc1cc(NC(=O)N2CCCc3cc(CN4CCOCC4=O)c(C=O)nc32)ncc1C#N CHEMBL4533697 IC50 1.3 nM
COCCNc1cc(NC(=O)N2CCCc3cc(CN(C)C(C)=O)c(C=O)nc32)ncc1C#N CHEMBL4759211 IC50 1.3 nM
COCCOc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)C(=O)C4)c(C=O)nc32)ncc1C#N CHEMBL4778828 IC50 1.3 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCOc5ccc(C(=O)NO)cc5)c4)nc3c2)c1 CHEMBL5181688 IC50 1.3 nM
COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCNCC4=O)c(C=O)nc32)ncc1C#N CHEMBL3974651 IC50 1.4 nM
N#Cc1cnc(NC(=O)N2CCCc3cc(CN4CCCCOC4=O)c(C=O)nc32)cc1N[C@H]1CCOC1 CHEMBL4532389 IC50 1.4 nM
COCCOc1cc(NC(=O)N2CCCc3cc(CN4C(=O)CN(C)CC4(C)C)c(C=O)nc32)ncc1C#N CHEMBL4789692 IC50 1.4 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)c(=O)n3c2)c1 CHEMBL4862576 IC50 1.4 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCCCCC(=O)NO)c4)nc3c2)c1 CHEMBL5177696 IC50 1.4 nM
C=CC(=O)Nc1cc(N2CCN(C)CC2)cc(F)c1Nc1n[nH]c2ccc(O[C@H](C)c3c(Cl)cncc3Cl)cc12 CHEMBL5169893 IC50 1.4 nM
COC[C@@H](C)Nc1cc(NC(=O)N2CCCc3cc(CN4CCCCOC4=O)c(C=O)nc32)ncc1C#N CHEMBL4475216 IC50 1.5 nM
COC[C@@H](C)Nc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc32)ncc1C#N CHEMBL4758510 IC50 1.5 nM
C=CC(=O)N1CC[C@H](c2nc(-c3cc4cc(Br)cc(OC)c4s3)c3c(N)nccn23)C1 CHEMBL5271030 IC50 1.5 nM
COCCOc1cc(NC(=O)N2CCCc3cc(CN4CC[C@@H](N(C)C)C4=O)c(C=O)nc32)ncc1C#N CHEMBL4752511 IC50 1.6 nM
CC(C)Oc1cc(NC(=O)c2cn(C)c3ccc(C=O)nc23)ncc1C#N CHEMBL5220871 IC50 1.6 nM
COc1cc(OC)cc(N(Cc2ncc[nH]2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3928393 pIC50 1.622 nM
COc1cc(OC)cc(N(CCCNC(=O)C(F)(F)F)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3983918 pIC50 1.622 nM
COc1cc(OC)cc(N(CCNS(=O)(=O)N(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3919173 pIC50 1.66 nM
C=CC(=O)N1CC(N2C=C(C#Cc3cc(OC)cc(OC)c3)C3C(N)=NC=NC32)C1 CHEMBL3701266 IC50 1.7 nM
N#Cc1cnc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)cc1NC1CCOC1 CHEMBL3964682 IC50 1.7 nM
COCCNc1cc(NC(=O)N2CCCc3cc(CN4CC[C@H](OC)C4=O)c(C=O)nc32)ncc1C#N CHEMBL4446965 IC50 1.7 nM
C=CS(=O)(=O)N1CC(n2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnc32)C1 CHEMBL4438578 IC50 1.7 nM
C=CC(=O)Nc1cc(CCN2CCC(NC(=O)OC(C)(C)C)CC2)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4847845 IC50 1.7 nM
N#Cc1cnc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)cc1NCC1CCCOC1 CHEMBL3986875 IC50 1.8 nM
C=CC(=O)Nc1cc(CCN(CCCN2CCCC2)C(=O)OC(C)(C)C)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4852633 IC50 1.8 nM
C=CC(=O)Nc1ccccc1Nc1ccc2c(C(=O)c3c(Cl)c(OC)cc(OC)c3Cl)c[nH]c2n1 CHEMBL5194417 IC50 1.8 nM
C=CC(=O)N1CCC(c2cc3c(Oc4ccc(NC(=O)NC5CC5)c(Cl)c4)ccnc3cc2OC)CC1 CHEMBL5439595 IC50 1.8 nM
CC(=O)N1CCN(Cc2cc3c(nc2C=O)N(C(=O)Nc2cc(OC(C)C)c(C#N)cn2)CCC3)CC1 CHEMBL3923150 IC50 1.9 nM
COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)C(O)C4=O)c(C=O)nc32)ncc1C#N CHEMBL3931083 IC50 1.9 nM
CN1CCN(Cc2cc3c(nc2C=O)N(C(=O)Nc2cc(NC45CC(C4)C5)c(C#N)cn2)CCC3)C(=O)C1 CHEMBL3944778 IC50 1.9 nM
C=CC(=O)Nc1cc(CCN2CCOCC2)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4869676 IC50 1.9 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3nc(-c4cnn(C)c4)cnc3c2)c1 CHEMBL5189383 IC50 1.9 nM
CN1CCN(CCNc2cc(NC(=O)c3cn(C)c4ccc(C=O)nc34)ncc2C#N)CC1 CHEMBL5218602 IC50 1.9 nM
COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O CHEMBL1289601 IC50 1.9 nM
COc1cc(OC)cc(N(CCCN2CC(O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907314 pIC50 1.905 nM
COCCNc1cc(NC(=O)N2CCCc3cc(CN(CCN(C)C)C(C)=O)c(C=O)nc32)ncc1C#N CHEMBL3960759 IC50 2.0 nM
C=CC(=O)Nc1ccccc1Nc1cc(N(Cc2ccccc2)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 CHEMBL3967316 IC50 2.0 nM
C=CC(=O)Nc1cc(N2CCN(CC)CC2)ccc1Nc1cc(N(C)C(=O)Nc2cc(OC)cc(OC)c2Cl)ncn1 CHEMBL3948664 IC50 2.0 nM
COCCOc1cc(NC(=O)N2CCCc3cc(Br)c(C=O)nc32)ncc1C#N CHEMBL4781882 IC50 2.0 nM
COCCOc1cc(NC(=O)N2CCCc3cc(CN(CCN(C)C)C(C)=O)c(C=O)nc32)ncc1C#N CHEMBL4780066 IC50 2.0 nM
C=CC(=O)Nc1cc(CCN2CCC(c3ccccc3)C2)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4855941 IC50 2.0 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3545376 IC50 2.0 nM
C=CC(=O)Nc1cc(N2CCN(C3COC3)CC2)ccc1Nc1ccc2c(C(=O)c3c(Cl)c(OC)cc(OC)c3Cl)c[nH]c2n1 CHEMBL5171741 IC50 2.0 nM
C=CC(=O)Nc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ccc2c(C(=O)c3cc(OC)cc(OC)c3)c[nH]c2n1 CHEMBL5196143 IC50 2.0 nM
CCS(=O)(=O)NCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3912569 pIC50 2.089 nM
COC[C@@H](C)Oc1cc(NC(=O)N2CCCc3cc(CN4CCCCOC4=O)c(C=O)nc32)ncc1C#N CHEMBL4446464 IC50 2.1 nM
COCCOc1cc(NC(=O)N2CCCc3cc(CN(C)C(C)=O)c(C=O)nc32)ncc1C#N CHEMBL4784243 IC50 2.1 nM
C=CC(=O)Nc1cc(N2CCOCC2)ccc1Nc1ccc2c(C(=O)c3cc(OC)cc(OC)c3)c[nH]c2n1 CHEMBL5201881 IC50 2.1 nM
COc1cc(OC)c(F)c(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1F CHEMBL3903973 pIC50 2.138 nM
CC(C)COc1cc(N2CCC(N(C)C)CC2)ccc1Nc1ncc(C#N)c(N[C@H]2[C@@H](C(N)=O)[C@@H]3C=C[C@H]2C3)n1 CHEMBL4279514 IC50 2.2 nM
C=CC(=O)Nc1cccc(Cl)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL5198859 IC50 2.2 nM
COc1cc(OC)cc(N(CCNS(=O)(=O)C(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3964574 pIC50 2.239 nM
N#Cc1cnc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)cc1NCCF CHEMBL3911846 IC50 2.3 nM
COCCNc1cc(NC(=O)N2CCCc3cc(CN(CCN(C)C)S(C)(=O)=O)c(C=O)nc32)ncc1C#N CHEMBL3929773 IC50 2.3 nM
COCCOc1cc(NC(=O)N2CCCc3cc(CN(CCN(C)C)S(C)(=O)=O)c(C=O)nc32)ncc1C#N CHEMBL4777580 IC50 2.3 nM
COCCOc1cc(NC(=O)N2CCCc3cc(C(F)F)c(C=O)nc32)ncc1C#N CHEMBL3904499 IC50 2.4 nM
COC[C@H](C)Nc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc32)ncc1C#N CHEMBL4787060 IC50 2.4 nM
C=CC(=O)Nc1cc(-c2cc3c(cn2)cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c(=O)n3CC)ccc1N1CCN(CC)CC1 CHEMBL5175788 IC50 2.4 nM
CN(C)CCNc1cc(NC(=O)c2cn(C)c3ccc(C=O)nc23)ncc1C#N CHEMBL5218768 IC50 2.4 nM
C=CC(=O)N1CC=C(c2cc3c(Oc4ccc(NC(=O)NC5CC5)c(Cl)c4)ccnc3cc2OC)C1 CHEMBL5425019 IC50 2.49 nM
CN1CCOC(CNc2cc(NC(=O)N3CCCc4cc(C(F)F)c(C=O)nc43)ncc2C#N)C1 CHEMBL3966195 IC50 2.5 nM
COCCOc1cc(NC(=O)N2c3nc(C=O)c(CN4CCN(C)CC4=O)cc3CC[C@@H]2C)ncc1C#N CHEMBL3969670 IC50 2.5 nM
COCCNc1cc(NC(=O)N2CCCc3cc(C4CCOCC4)c(C=O)nc32)ncc1C#N CHEMBL3912070 IC50 2.5 nM
COc1cc(OC)cc(N(C[C@@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3913322 pIC50 2.512 nM
COCCNc1cc(NC(=O)N2CCCc3cc(CN4C[C@@H](C)N[C@@H](C)C4)c(C=O)nc32)ncc1C#N CHEMBL3955341 IC50 2.6 nM
C=CC(=O)Nc1cc(F)cc(Cl)c1Nc1ncc(OCc2c(Cl)c(OC)cc(OC)c2Cl)cn1 CHEMBL4065231 IC50 2.6 nM
COCCOc1cc(NC(=O)N2CCCc3cc(CN4C[C@@H](C)N[C@@H](C)C4)c(C=O)nc32)ncc1C#N CHEMBL4752290 IC50 2.6 nM
C=CC(=O)Nc1cc(CCN2CCc3ccccc3C2)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4869377 IC50 2.6 nM
C=CC(=O)Nc1cc(N2CCN(CC)CC2)cc(OC)c1Nc1cc2c(cn1)cc(-c1c(Cl)c(OC)cc(OC)c1Cl)c(=O)n2CC CHEMBL5193663 IC50 2.6 nM
COc1cc(OC)cc(N(CCCNC(=O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3891892 pIC50 2.63 nM
CO[C@H]1CCOC[C@@H]1Oc1cc(NC(=O)N2CCCc3cc(CN4CCOCC4=O)c(C=O)nc32)ncc1C#N CHEMBL4553307 IC50 2.7 nM
COc1cc(OC)c(F)c(N(CCCNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1F CHEMBL3892529 pIC50 2.754 nM
C=CC(=O)Nc1cc(OCCN(C)C)ccc1Nc1ccc2c(C(=O)c3c(Cl)c(OC)cc(OC)c3Cl)c[nH]c2n1 CHEMBL5170353 IC50 2.8 nM
COc1cc(OC)cc(N(Cc2cc(C)no2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3898908 pIC50 2.818 nM
C=CC(=O)N1CC=C(c2cc3c(Oc4ccc(NC(=O)NC5CC5)c(Cl)c4)ccnc3cc2OC)CC1 CHEMBL5434390 IC50 2.88 nM
COc1cc(OC)cc(N(CCCN2CCCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3904674 pIC50 2.884 nM
N#Cc1cnc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)cc1OC1CCOCC1 CHEMBL3920201 IC50 2.9 nM
COCCNc1cc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)ncc1C#N CHEMBL3972276 IC50 2.9 nM
COCCNc1cc(NC(=O)N2CCCc3cc(-c4cnc(C)s4)c(C=O)nc32)ncc1C#N CHEMBL3951479 IC50 3.0 nM
COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)/C=C/Cl)ncn2)c1Cl CHEMBL3941999 IC50 3.0 nM
C=CC(=O)Nc1ccccc1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4090527 IC50 3.0 nM
C=CC(=O)Nc1cccc(C)c1Nc1ncc(OCc2c(F)c(OC)cc(OC)c2F)cn1 CHEMBL4089245 IC50 3.0 nM
Cn1cc(C(=O)Nc2cc(NCCN3CCOCC3)c(C#N)cn2)c2nc(C=O)ccc21 CHEMBL5220411 IC50 3.0 nM
COc1cc(OC)cc(N(CCCNC(=O)C(C)(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3935825 pIC50 3.02 nM
COc1cc(OC)cc(N(CCCNC(=O)C(C)(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3897101 pIC50 3.02 nM
COc1cc(OC)cc(N(CCCN2CCC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3906894 pIC50 3.02 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3918092 pIC50 3.09 nM
CN(C)CC(C)(C)COc1cc(NC(=O)N2CCCc3cc(C(F)F)c(C=O)nc32)ncc1C#N CHEMBL4779862 IC50 3.1 nM
COc1ccnc(C#CCN(c2ccc3ncc(-c4cnn(C)c4)nc3c2)c2c(F)c(OC)cc(OC)c2F)n1 CHEMBL3978754 pIC50 3.162 nM
COCCOc1cc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)ncc1C#N CHEMBL3983290 IC50 3.2 nM
COCC(C)Oc1cc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)ncc1C#N CHEMBL3940560 IC50 3.2 nM
CC(C)Oc1cc(NC(=O)n2ccc3ccc(C=O)nc32)ncc1C#N CHEMBL4294292 IC50 3.2 nM
C[C@@H](Oc1ccc2[nH]nc(/C=C/c3cnn(CCO)c3)c2c1)c1c(Cl)cncc1Cl CHEMBL3828009 IC50 3.2 nM
C=CC(=O)Nc1cc(CC(=O)O)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4870186 IC50 3.2 nM
C=CC(=O)Nc1cc(CCCN2CCCC2)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4859949 IC50 3.2 nM
C=CC(=O)Nc1cc(N2CCN(C)CC2)ccc1Nc1ccc2c(C(=O)c3c(Cl)c(OC)cc(OC)c3Cl)c[nH]c2n1 CHEMBL5175947 IC50 3.2 nM
C=CC(=O)Nc1cc(N2CCN(CC)CC2)ccc1Nc1cc2c(cn1)cc(-c1c(Cl)c(OC)cc(OC)c1Cl)c(=O)n2CC CHEMBL5180280 IC50 3.2 nM
CC#CC(=O)Nc1cc(-c2cc3c(cn2)cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c(=O)n3CC)c(OC)cc1N1CCN(CC)CC1 CHEMBL5186125 IC50 3.2 nM
COc1cc(OC)cc(N(CCNC(C)=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3945373 pIC50 3.236 nM
COc1cc(OC)cc(N(CC(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3911635 pIC50 3.236 nM
C=CC(=O)Nc1ccc2ncccc2c1Nc1cc2c(cn1)cc(-c1c(Cl)c(OC)cc(OC)c1Cl)c(=O)n2CC CHEMBL5185308 IC50 3.3 nM
C=CC(=O)Nc1cc(-c2cc3c(cn2)cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c(=O)n3CC)c(OC)cc1N1CCN(CC)CC1 CHEMBL5204828 IC50 3.3 nM
C[C@@H](Oc1cc(NC(=O)c2cn(CCN3CCOCC3)c3cc(Br)c(C=O)nc23)ncc1C#N)c1c(Cl)cncc1Cl CHEMBL5220381 IC50 3.3 nM
CCn1cc(-c2cnc3ccc(N(CCNC(C)C)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3945159 pIC50 3.388 nM
C=CC(=O)N1CC[C@H](n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701238 IC50 3.4 nM
CN1CCC2(CCN(c3cc(NC(=O)N4CCCc5ccc(C=O)nc54)ncc3C#N)CC2)C1 CHEMBL3985916 IC50 3.4 nM
CN1CCC(COc2cc(NC(=O)N3CCCc4cc(C(F)F)c(C=O)nc43)ncc2C#N)CC1 CHEMBL4785725 IC50 3.4 nM
COc1cc(OC)cc(N(CCCN2CCC(F)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3975447 pIC50 3.467 nM
CC(C)Oc1cc(NC(=O)N2CCCc3cc(C4CCNCC4)c(C=O)nc32)ncc1C#N CHEMBL3972471 IC50 3.5 nM
CO[C@H]1CCN(c2cc(NC(=O)N3CCCc4cc(CN5CCOCC5=O)c(C=O)nc43)ncc2C#N)C1 CHEMBL4571626 IC50 3.5 nM
C#CCN(c1ccc2ncc(-c3cnn(C)c3)nc2c1)c1c(F)c(OC)cc(OC)c1F CHEMBL3935597 pIC50 3.548 nM
C=CC(=O)Nc1cc(CCC(=O)O)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4877860 IC50 3.6 nM
C=CC(=O)Nc1cc(CCN(C)C)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4865511 IC50 3.6 nM
C=CC(=O)Nc1cc(-c2cc3c(cn2)cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c(=O)n3CC)c(OC)cc1N1CCN(C(C)=O)CC1 CHEMBL5184648 IC50 3.6 nM
C=CC(=O)Nc1cc(N2CCOCC2)ccc1Nc1ccc2c(C(=O)c3c(Cl)c(OC)cc(OC)c3Cl)c[nH]c2n1 CHEMBL5193819 IC50 3.7 nM
COc1cc(OC)cc(N(CCCN2CCC[C@H]2CNS(=O)(=O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3933000 pIC50 3.715 nM
COc1cc(OC)cc(N(CCC(=O)NCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3937972 pIC50 3.715 nM
C=CC(=O)Nc1cccc(Cl)c1Nc1ncc(OCc2c(Cl)c(OC)cc(OC)c2Cl)cn1 CHEMBL4073826 IC50 3.8 nM
C#CC(=O)N1CCC(n2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnc32)C1 CHEMBL4461734 IC50 3.8 nM
COCCNc1cc(NC(=O)c2cn(C)c3cc(Br)c(C=O)nc23)ncc1C#N CHEMBL5220583 IC50 3.8 nM
COc1cc(OC)cc(N(Cc2nnc(N)o2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3968009 pIC50 3.802 nM
COc1cc(OC)cc(N(CC(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3900574 pIC50 3.802 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3893786 pIC50 3.802 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCC#N)c4)nc3c2)c1 CHEMBL3958209 pIC50 3.802 nM
COC(C)CNc1cc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)ncc1C#N CHEMBL3978608 IC50 3.9 nM
C=CC(=O)Nc1cccc(C)c1Nc1cc2c(cn1)cc(-c1c(Cl)c(OC)cc(OC)c1Cl)c(=O)n2C1CC1 CHEMBL5179371 IC50 3.9 nM
C=CC(=O)Nc1cc(-c2cc3c(cn2)cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c(=O)n3CC)c(OC)cc1N1C[C@@H](C)N(CC)[C@@H](C)C1 CHEMBL5173193 IC50 3.9 nM
COc1cc(OC)cc(N(CCC#N)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3913757 pIC50 3.981 nM
COc1cc(OC)cc(N(CCCN2CCC(C(F)(F)F)CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3936087 pIC50 3.981 nM
C=CC(=O)Nc1ccccc1Nc1cc(N(CCOC)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 CHEMBL3952638 IC50 4.0 nM
C=CC(=O)Nc1ccc(N2CCN(CC)CC2)cc1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 CHEMBL3914013 IC50 4.0 nM
C=CC(=O)Nc1cccc(C)c1Nc1ncc(OCc2c(Cl)c(OC)cc(OC)c2Cl)cn1 CHEMBL4061083 IC50 4.0 nM
C=CC(=O)Nc1cc(N2CCN(CC)CC2)cc(C)c1Nc1ncc(OCc2c(F)c(OC)cc(OC)c2F)cn1 CHEMBL4081380 IC50 4.0 nM
C=CC(=O)Nc1cc(-c2cc3c(cn2)cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c(=O)n3CC)c(OC)cc1N(C)CCN(C)C CHEMBL5170061 IC50 4.0 nM
C=CC(=O)Nc1cc(-c2cc3c(cn2)cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c(=O)n3CC)c(OC)cc1N1C[C@@H](C)N[C@@H](C)C1 CHEMBL5192973 IC50 4.0 nM
COc1cc(OC)cc(N(CCCN2CCC(O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3984039 pIC50 4.074 nM
N#Cc1cnc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)cc1O[C@H]1CCOC1 CHEMBL3916036 IC50 4.1 nM
COc1cc(Nc2ncc(CCc3c(F)c(OC)cc(OC)c3F)cn2)ccc1N1CCC(N2CCN(C)CC2)CC1 CHEMBL4763773 IC50 4.2 nM
COCCn1cc(-c2cnc3ccc(N(Cc4cc(C)no4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3985692 pIC50 4.266 nM
CNCCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3968499 pIC50 4.266 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3892776 pIC50 4.266 nM
COc1cc(OC)cc(N(CCC(C)(C)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3950910 pIC50 4.266 nM
[2H]C([2H])([2H])Oc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3975791 pIC50 4.365 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CC5CCOCC5)c4)nc3c2)c1 CHEMBL3926082 pIC50 4.365 nM
COc1cccnc1C#CCN(c1ccc2ncc(-c3cnn(C)c3)nc2c1)c1c(F)c(OC)cc(OC)c1F CHEMBL3976275 pIC50 4.365 nM
COc1cc(OC)cc(N(Cc2cc(C)no2)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3951245 pIC50 4.467 nM
COc1cc(OC)cc(N(CCCN)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3922698 pIC50 4.467 nM
N#Cc1cnc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)cc1O[C@@H]1CCOC1 CHEMBL4106685 IC50 4.5 nM
COCCOc1cc(NC(=O)N2CCCc3cc(CN4CCOCC4=O)c(C=O)nc32)ncc1C#N CHEMBL4556198 IC50 4.5 nM
C=CC(=O)N[C@H]1COC[C@H]1Nc1ncc2cc(-c3c(F)c(OC)cc(OC)c3F)c(=O)n(C)c2n1 CHEMBL4752717 IC50 4.5 nM
CC(C)Oc1cc(NC(=O)N2CCCc3ccc(C=O)nc32)ncc1C#Cc1cccnc1 CHEMBL5090776 IC50 4.5 nM
COc1cc(OC)cc(N(CC2COCC(C)(C)N2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3901119 pIC50 4.571 nM
CO[C@@H]1CCN(c2cc(NC(=O)N3CCCc4cc(CN5C(=O)OC[C@@H]5C)c(C=O)nc43)ncc2C#N)C1 CHEMBL4564505 IC50 4.6 nM
COCCSc1cc(NC(=O)N2CCCc3cc(CN4CCOCC4=O)c(C=O)nc32)ncc1C#N CHEMBL4587476 IC50 4.6 nM
COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C1CCN(C(=O)/C=C/CN(C)C)CC1 CHEMBL5431098 IC50 4.6 nM
C=CS(=O)(=O)N1CC=C(c2cc3c(Oc4ccc(NC(=O)NC5CC5)c(Cl)c4)ccnc3cc2OC)CC1 CHEMBL5439019 IC50 4.65 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3931421 pIC50 4.677 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(C5CCCCO5)c4)nc3c2)c1 CHEMBL3980232 pIC50 4.677 nM
COc1cc(OC)cc(N(Cc2cn(CCO)nn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921457 pIC50 4.677 nM
COc1cc(OC)cc(N(CCCN2CCC[C@@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3942763 pIC50 4.677 nM
COc1cc(OC)cc(N(CC#Cc2cc(N)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3902961 pIC50 4.677 nM
COc1cc(OC)cc(N(CCP(=O)(O)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3950169 pIC50 4.677 nM
CO[C@@H]1CCN(c2cc(NC(=O)N3CCCc4cc(CN5CCOC5=O)c(C=O)nc43)ncc2C#N)C1 CHEMBL4470137 IC50 4.7 nM
[2H]C([2H])([2H])n1cc(-c2cnc3ccc(N(CCNC(C)C)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3919709 pIC50 4.786 nM
CCCn1cc(-c2cnc3ccc(N(CCN)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3959573 pIC50 4.786 nM
COc1cc(OC)cc(N(C[C@@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3905276 pIC50 4.786 nM
COc1cc(OC)cc(N(CC(=O)Nc2cc(O)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3894762 pIC50 4.786 nM
C=CC(=O)Nc1cccc(OC)c1Nc1ncc(OCc2c(Cl)c(OC)cc(OC)c2Cl)cn1 CHEMBL4067483 IC50 4.8 nM
C=CC(=O)Nc1cc(-c2cc3c(cn2)cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c(=O)n3CC)c(OC)cc1N1C[C@H]2C[C@@H]1CO2 CHEMBL5188086 IC50 4.8 nM
COc1cc(OC)cc(N(Cc2cc(C)on2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3979490 pIC50 4.898 nM
C=CC(=O)N1CC(n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 CHEMBL3701241 IC50 4.9 nM
CC(C)(O)CNc1cc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)ncc1C#N CHEMBL3889875 IC50 4.9 nM
COCCNc1cc(NC(=O)N2CCCc3ccc(C=O)nc32)ncc1C#Cc1ccccn1 CHEMBL5082899 IC50 4.9 nM
COCCOc1cc(NC(=O)N2CCCc3ccc(C=O)nc32)ncc1C#Cc1cccnc1 CHEMBL5084777 IC50 4.9 nM
N#Cc1ccc(NC(=O)N2CCCc3ccc(C=O)nc32)nc1 CHEMBL3971213 Kd 5.0 nM
COC[C@H](C)Nc1cc(NC(=O)N2CCCc3cc(CN4CC[C@H](OC)C4=O)c(C=O)nc32)ncc1C#N CHEMBL4544586 IC50 5.0 nM
C=CC(=O)N[C@H]1CCOC[C@H]1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4514636 IC50 5.0 nM
COc1cc(OC)cc(N(CC(F)CN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3908149 pIC50 5.012 nM
COc1cc(OC)cc(N(CC#Cc2cc(OC)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3927140 pIC50 5.012 nM
COc1cc(OC)cc(N(CCCN2CCC(N)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3919730 pIC50 5.129 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCCN4CCCC4)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3972979 pIC50 5.129 nM
N#Cc1cnc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)cc1OCC1CCCO1 CHEMBL3899879 IC50 5.2 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3955563 pIC50 5.248 nM
C=CC(=O)Nc1cccc(F)c1Nc1ncc(OCc2c(Cl)c(OC)cc(OC)c2Cl)cn1 CHEMBL4102146 IC50 5.3 nM
N#Cc1cnc(NC(=O)N2CCCc3cc(CN4CCOCC4=O)c(C=O)nc32)cc1S[C@H]1CCOC1 CHEMBL4472588 IC50 5.3 nM
C=CC(=O)N1CC[C@H](n2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnc32)C1 CHEMBL4475243 IC50 5.3 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCCO)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3954298 pIC50 5.37 nM
COc1cc(OC)c(Cl)c(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3986068 pIC50 5.37 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(CCCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921441 pIC50 5.37 nM
CCOc1cc(NC(=O)N2CCCc3ccc(C=O)nc32)ncc1C#N CHEMBL3962493 IC50 5.4 nM
C=CC(=O)N1CC(n2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnc32)C1 CHEMBL4469557 IC50 5.4 nM
CC(C)Oc1cc(NC(=O)N2CCCc3ccc(C=O)nc32)ncc1C#Cc1ccccn1 CHEMBL5069727 IC50 5.4 nM
CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc32)ncc1C#Cc1cccnc1 CHEMBL5092315 IC50 5.4 nM
C=CC(=O)Nc1cccc(C)c1Nc1cc2[nH]c(=O)c(-c3c(Cl)c(OC)cc(OC)c3Cl)cc2cn1 CHEMBL5191143 IC50 5.4 nM
CC#CC(=O)Nc1cc(-c2cc3c(cn2)cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c(=O)n3CC)c(OC)cc1N1C[C@H]2C[C@@H]1CO2 CHEMBL5200584 IC50 5.4 nM
COc1cc(OC)cc(N(CCCN)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3979013 pIC50 5.495 nM
COc1cc(OC)cc(N(CCCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3934260 pIC50 5.495 nM
N#Cc1cnc(NC(=O)N2CCCc3ccc(C=O)nc32)cc1C1=CCOCC1 CHEMBL3897114 IC50 5.5 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(C#Cc4cncc(N5CCOCC5)c4)c3)cc2C(F)(F)F)CC1 CHEMBL4091628 IC50 5.5 nM
C=CC(=O)Nc1cc(CCNCCCN2CCCC2)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4858227 IC50 5.5 nM
C=CC(=O)Nc1cc(CCO)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4852405 IC50 5.5 nM
COc1cccc(-c2ccc3c(NC(=O)c4cccc(NC(=O)CCl)c4)n[nH]c3c2)c1F CHEMBL4779598 IC50 5.6 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3958153 pIC50 5.623 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3898881 pIC50 5.623 nM
COCC(O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C(C)C)c3)nc2c1 CHEMBL3984461 pIC50 5.623 nM
COCC(O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C(C)C)c3)nc2c1 CHEMBL3981955 pIC50 5.623 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C(C)CNCC(F)(F)F)c1 CHEMBL3890852 pIC50 5.623 nM
COc1cc(OC)cc(N(CCCNC(C)(C)CF)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921469 pIC50 5.623 nM
COc1cc(OC)cc(N(CCCNCC(N)=O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3960877 pIC50 5.623 nM
N#Cc1cnc(NC(=O)N2CCCc3cc(CN4CCCC4=O)c(C=O)nc32)cc1OCC1CCNC(=O)C1 CHEMBL3945443 IC50 5.7 nM
C=CC(=O)Nc1cc(CCN2CCCC2)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4849814 IC50 5.7 nM
C=CC(=O)Nc1cc(-c2cnn(C)c2)ccc1Nc1ccc2c(C(=O)c3cc(OC)cc(OC)c3)c[nH]c2n1 CHEMBL5186333 IC50 5.7 nM
C=CC(=O)N1CCC(c2cc3c(Oc4ccc(NC(=O)NC5CC5)c(Cl)c4)ccnc3cc2OC)C(C)C1 CHEMBL5427478 IC50 5.73 nM
COc1cc(OC)cc(N(CCCN2CCC[C@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3949132 pIC50 5.754 nM
[2H]C([2H])([2H])Oc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3925081 pIC50 5.754 nM
COc1cc(OC)cc(N(C[C@H](O)CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3939764 pIC50 5.754 nM
COc1cc(OC)cc(N(Cc2ccc(Cl)nc2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907642 pIC50 5.754 nM
COCCOc1cc(NC(=O)N2CCCc3cc(C(F)(F)F)c(C=O)nc32)ncc1C#N CHEMBL3966721 IC50 5.8 nM
C=CC(=O)Nc1cc(-c2cnn(C)c2)ccc1Nc1ccc2c(C(=O)c3c(Cl)c(OC)cc(OC)c3Cl)c[nH]c2n1 CHEMBL5199418 IC50 5.8 nM
COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCCC45COC5)c(C=O)nc32)ncc1C#N CHEMBL3986663 IC50 5.9 nM
CC(C)Oc1cc(NC(=O)N2CCCc3ccc(C=O)nc32)ncc1C#Cc1cncnc1 CHEMBL5082992 IC50 5.9 nM
CC1(O)CCN(c2cc(NC(=O)N3CCCc4cc(CO)c(C=O)nc43)ncc2C#N)CC1 CHEMBL3894459 IC50 6.0 nM
C=CC(=O)Nc1cc(N2CCN(CC)CC2)ccc1Nc1cc(N(C)C(=O)Nc2cc(OC)cc(OC)c2)ncn1 CHEMBL3976424 IC50 6.0 nM
C=CC(=O)Nc1cc(N2CCN(C(C)=O)CC2)cc(C)c1Nc1ncc(OCc2c(F)c(OC)cc(OC)c2F)cn1 CHEMBL4099401 IC50 6.0 nM
C=CS(=O)(=O)N[C@H]1COC[C@H]1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(C)c2n1 CHEMBL4759172 IC50 6.0 nM
[2H]C([2H])([2H])Oc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3981418 pIC50 6.026 nM
COc1cc(OC)cc(N(CCNC(=O)C2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3963323 pIC50 6.026 nM
COc1cc(OC)cc(N(CCCN2CC=CCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3919479 pIC50 6.026 nM
C[C@@H](Oc1ccc2[nH]nc(-c3nc4cc(N5CCN(C)CC5)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3827178 IC50 6.1 nM
C=CC(=O)N1CCCC(n2nc3c(=O)[nH]nc(N)c3c2-c2oc3ccc(C)cc3c2C)C1 CHEMBL5274338 IC50 6.1 nM
COc1cc(OC)cc(N(CCC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3951126 pIC50 6.166 nM
[2H]C([2H])([2H])Oc1cc(OC([2H])([2H])[2H])cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)C([2H])([2H])C([2H])([2H])NC(C)C)c1 CHEMBL3918638 pIC50 6.166 nM
C=CC(=O)N1CCC(n2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnc32)C1 CHEMBL4560984 IC50 6.2 nM
COc1cc(NC(=O)N2CCCc3ccc(C=O)nc32)ncc1C#N CHEMBL3933682 IC50 6.3 nM
O=Cc1ccc2c(n1)N(C(=O)Nc1ncc(Cl)c(OC3CCOC3)n1)CCC2 CHEMBL3938882 IC50 6.3 nM
C=CC(=O)Nc1ccc(/C=C/c2nc(Nc3cc(C(C)C)[nH]n3)cc(N3CCN(C)CC3)n2)cc1 CHEMBL4776177 GI50 6.4 nM
COC[C@@H](C)Nc1cc(NC(=O)N2CCCc3ccc(C=O)nc32)ncc1C#Cc1cccnc1 CHEMBL5086939 IC50 6.4 nM
C=CC(=O)Nc1cccc(C)c1Nc1cc2c(cn1)cc(-c1c(Cl)c(OC)cc(OC)c1Cl)c(=O)n2CC CHEMBL5172762 IC50 6.4 nM
COCCNc1cc(NC(=O)c2cn(C)c3cc(CN4CCN(C)CC4=O)c(C=O)nc23)ncc1C#N CHEMBL5219987 IC50 6.4 nM
COc1cc(OC)cc(N(CCNC(=O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3912831 pIC50 6.457 nM
COc1cc(OC)cc(N(CCCN2CCC[C@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3936672 pIC50 6.457 nM
COc1cc(OC)cc(N(Cc2cn[nH]n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3904561 pIC50 6.457 nM
COc1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cnn(CC5CCOCC5)c4)nc3c2)c1 CHEMBL3966305 pIC50 6.457 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CCN(C(=O)OC(C)(C)C)CC5)c4)nc3c2)c1 CHEMBL3896249 pIC50 6.457 nM
COCCNc1cc(NC(=O)N(C)c2cccc(C=O)n2)ncc1C#N CHEMBL4287768 IC50 6.5 nM
C=CC(=O)N[C@H]1COC[C@H]1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(C)c2n1 CHEMBL4761518 IC50 6.5 nM
C=CC(=O)N[C@H]1COC[C@H]1Nc1ncc2cc(-c3c(F)c(OC)cc(OC)c3Cl)c(=O)n(C)c2n1 CHEMBL4793545 IC50 6.5 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3961210 pIC50 6.607 nM
COc1cc(OC)cc(N(CCCN2CCCCC2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3905485 pIC50 6.607 nM
COc1cc(OC)c(Cl)c(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3922586 pIC50 6.607 nM
COc1cc(OC)cc(N(CCN2CCC[C@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3943860 pIC50 6.607 nM
COCCNc1cc(NC(=O)N2CCCc3cc(-c4cn(C)nc4C)c(C=O)nc32)ncc1C#N CHEMBL3890235 IC50 6.7 nM
COCCNc1cc(NC(=O)N2CCCc3ccc(C=O)nc32)ncc1C#Cc1cccnc1 CHEMBL5082671 IC50 6.7 nM
C=CC(=O)Nc1cc(OCCOC)ccc1Nc1ccc2c(C(=O)c3c(Cl)c(OC)cc(OC)c3Cl)c[nH]c2n1 CHEMBL5192936 IC50 6.7 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3949470 pIC50 6.761 nM
COc1cc(OC)cc(N(CCCN2CCC(N3CCCCC3)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3971277 pIC50 6.761 nM
COc1cc(OC)c(Cl)c(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3892135 pIC50 6.761 nM
COc1cc(OC)cc(N(CCNC(=O)C(C)(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3899692 pIC50 6.761 nM
COc1cc(OC)cc(N(CCNCC(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3905866 pIC50 6.761 nM
COc1cc(OC)cc(N(c2ccc3ncc(-c4cnn(C)c4)nc3c2)[C@H]2CC[C@@H](NC(C)C)CC2)c1 CHEMBL3911621 pIC50 6.761 nM
N#Cc1cnc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)cc1NC1CCOCC1 CHEMBL3951350 IC50 6.8 nM
COc1ccc(F)c(-c2ccc3c(NC(=O)c4cccc(NC(=O)CCl)c4)n[nH]c3c2)c1 CHEMBL4748343 IC50 6.8 nM
COc1cc(OC)cc(N(CCCN)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3966748 pIC50 6.918 nM
COc1cc(OC)cc(N(CC#CC(C)(C)O)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3924172 pIC50 6.918 nM
CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc32)ncc1C#Cc1ccccn1 CHEMBL5070701 IC50 7.0 nM
C=CC(=O)Nc1cc(-c2cc3c(cn2)cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c(=O)n3CC)c(OC)nc1N1CCN(CC)CC1 CHEMBL5200589 IC50 7.0 nM
[2H]C([2H])([2H])Oc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C1CCN(C(=O)C=C)CC1 CHEMBL5420584 IC50 7.04 nM
[2H]C([2H])([2H])n1cc(-c2ccc3ncc(N(CCO)c4cc(OC)cc(OC)c4)nc3c2)cn1 CHEMBL3959849 pIC50 7.079 nM
COc1cc(F)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3918739 pIC50 7.079 nM
COc1cc(OC)cc(N(CCCN2[C@H](C)CC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3902353 pIC50 7.079 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 IC50 7.1 nM
COC[C@H](C)Nc1cc(NC(=O)N2CCCc3ccc(C=O)nc32)ncc1C#Cc1cccnc1 CHEMBL5087611 IC50 7.1 nM
COc1cc(CCc2cnc(NC(=O)N3CCCc4cc(CN5CCN(C)CC5=O)c(C=O)nc43)cc2OC(C)C)cc(OC)c1 CHEMBL5069857 IC50 7.15 nM
COCCOc1cc(NC(=O)N2CCCc3ccc(C=O)nc32)ncc1C#Cc1ccccn1 CHEMBL5088289 IC50 7.2 nM
COc1cc(OC)cc(N(C[C@@H]2CCCN2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3979170 pIC50 7.244 nM
COc1cc(OC)cc(N(Cc2csc(C)n2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3961872 pIC50 7.244 nM
COc1cc(OC)cc(N(CCNC2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3923296 pIC50 7.244 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3970430 pIC50 7.244 nM
COC[C@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C(C)C)c3)nc2c1 CHEMBL3926556 pIC50 7.244 nM
COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3cnn(C4CCN(C(C)C)CC4)c3)n2)c1Cl CHEMBL5193966 IC50 7.3 nM
OC[C@H](Nc1cnc(-c2cc(Cl)ccc2O)c(-c2ccc3cnccc3c2)c1)c1ccccc1 CHEMBL4067871 IC50 7.4 nM
COCCNc1cc(NC(=O)N(CCOC)c2cccc(C=O)n2)ncc1C#N CHEMBL4279848 IC50 7.4 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3918751 pIC50 7.413 nM
COc1cc(OC)cc(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3947189 pIC50 7.413 nM
COc1cc(OC)cc(N(CCCN2CCCC(C(N)=O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3910444 pIC50 7.413 nM
COc1cc(OC)cc(N(CCCN2[C@@H](C)CC[C@@H]2C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3968139 pIC50 7.413 nM
COc1cc(OC)cc(N(CCNCCF)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3960571 pIC50 7.413 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CCOCC5)c4)nc3c2)c1 CHEMBL3913492 pIC50 7.413 nM
C=CC(=O)Nc1cc(C)ccc1Nc1ncc(OCc2c(Cl)c(OC)cc(OC)c2Cl)cn1 CHEMBL4077138 IC50 7.5 nM
N#Cc1cnc(NC(=O)N2CCCc3cc(CN4CCOCC4=O)c(C=O)nc32)cc1S[C@@H]1CCOC1 CHEMBL4471457 IC50 7.5 nM
COc1cc(OC)c(C)c(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3932285 pIC50 7.586 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3940175 pIC50 7.586 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4C)nc3c2)c1 CHEMBL3966071 pIC50 7.586 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3898355 pIC50 7.762 nM
COc1cc(OC)cc(N(CC(O)CNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3978453 pIC50 7.762 nM
COc1cc(OC)cc(N(CCCN2CCC(S(C)(=O)=O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3933707 pIC50 7.762 nM
COc1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1 CHEMBL3941700 pIC50 7.762 nM
COc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C5CCN(C(=O)OC(C)(C)C)CC5)c4)nc3c2)c1 CHEMBL3977010 pIC50 7.762 nM
C=CC(=O)Nc1cc(CC(=O)OC)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4859584 IC50 7.8 nM
C=CC(=O)Nc1cc(-c2cc3c(cn2)cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c(=O)n3CC)c(C)cc1N1CCN(CC)CC1 CHEMBL5173719 IC50 7.8 nM
COc1cc(OC)cc(N(CC(O)CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3943387 pIC50 7.943 nM
COc1cc(OC)cc(N(CCCN2CCC(N3C[C@@H](C)O[C@@H](C)C3)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3961400 pIC50 7.943 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCCN)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3942328 pIC50 7.943 nM
COc1cc(OC)cc(N(CCN2CCCC(C(N)=O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3931790 pIC50 7.943 nM
C=CC(=O)Nc1ccccc1Nc1ncc(OCc2c(F)c(OC)cc(OC)c2F)cn1 CHEMBL4070782 IC50 8.0 nM
C=CC(=O)Nc1cc(N2CCN(C3COC3)CC2)cc(F)c1Nc1n[nH]c2ccc(O[C@H](C)c3c(Cl)cncc3Cl)cc12 CHEMBL5193422 IC50 8.0 nM
N#Cc1cnc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)cc1OCC1CCCCO1 CHEMBL3982349 IC50 8.1 nM
COCCOc1cc(NC(=O)N2CCCc3cc(C4CCN(C5COC5)CC4)c(C=O)nc32)ncc1C#N CHEMBL4744460 IC50 8.1 nM
COc1cc(OC)cc(N(CCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3985222 pIC50 8.128 nM
COc1cc(OC)cc(N(CCCO)c2ccc3ncc(-c4cnn(CCO)c4)nc3c2)c1 CHEMBL3893008 pIC50 8.128 nM
COc1cc(OC)cc(N(CCN)c2ccc3ncc(-c4cnn(CCS(C)(=O)=O)c4)nc3c2)c1 CHEMBL3951694 pIC50 8.128 nM
COc1cc(OC)cc(N(C[C@@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(CCCN)c4)nc3c2)c1 CHEMBL3964701 pIC50 8.128 nM
CN1CCN(Cc2cc3c(nc2C=O)N(C(=O)Nc2cc(NCCOS(=O)(=O)O)c(C#N)cn2)CCC3)C(=O)C1 CHEMBL3968952 IC50 8.2 nM
COCCNc1cc(NC(=O)N2CCCc3cc(C4CCN(C5COC5)CC4)c(C=O)nc32)ncc1C#N CHEMBL3950552 IC50 8.2 nM
C=CC(=O)Nc1ccccc1Nc1ncc(OCc2c(Cl)c(OC)cc(OC)c2Cl)cn1 CHEMBL4082818 IC50 8.2 nM
COCCOc1cc(NC(=O)N2CCCc3cc(C4CC4)c(C=O)nc32)ncc1C#N CHEMBL3932491 IC50 8.3 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCNC(C)C)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3909551 pIC50 8.318 nM
COc1cc(OC)cc(N(CCN2CCC[C@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907195 pIC50 8.318 nM
COc1cc(OC)cc(N(C[C@H](O)CNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3975397 pIC50 8.318 nM
C=CC(=O)Nc1cc(Cl)cc(Cl)c1Nc1ncc(OCc2c(Cl)c(OC)cc(OC)c2Cl)cn1 CHEMBL4086669 IC50 8.5 nM
C=CC(=O)Nc1cc(S(N)(=O)=O)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4872856 IC50 8.5 nM
CNC(=O)Cn1cc(-c2cnc3ccc(N(CCO)c4cc(OC)cc(OC)c4)cc3n2)cn1 CHEMBL3909565 pIC50 8.511 nM
COc1cc(OC)cc(N(Cc2csc(C)n2)c2ccc3ncc(-c4cnn(CCN5CCNCC5)c4)nc3c2)c1 CHEMBL3921197 pIC50 8.511 nM
COc1cc(OC)cc(N(CCNCCC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3951847 pIC50 8.511 nM
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C5CCNCC5)c4)nc3c2)c1 CHEMBL3980069 pIC50 8.511 nM
COc1cc(C#Cc2cnc(NC(=O)N3CCCc4cc(CN5CCN(C)CC5=O)c(C=O)nc43)cc2OC(C)C)cc(OC)c1 CHEMBL5076701 IC50 8.55 nM
COc1cc(OC)cc(-c2ccc3c(NC(=O)c4cccc(NC(=O)CCl)c4)n[nH]c3c2)c1 CHEMBL4757428 IC50 8.6 nM
C=CC(=O)Nc1cc(CCN2CCC(N)CC2)cc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 CHEMBL4871076 IC50 8.6 nM
COc1ccc(OC)c(S(=O)(=O)n2ccc3cnc(Nc4ccc(N5CCN(C)CC5)cc4)nc32)c1 CHEMBL5290554 IC50 8.7 nM
CNC[C@H](O)CN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(C)c3)nc2c1 CHEMBL3968124 pIC50 8.71 nM
COc1cc(OC)cc(N(CCNCC2CC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3935457 pIC50 8.71 nM
COc1cc(OC)cc(N(CCCN2CCC[C@@H]2CC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3948744 pIC50 8.71 nM
COc1cc(OC)cc(N(CCCNCC(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3934080 pIC50 8.71 nM
COCCNc1cc(NC(=O)N2CCCc3cc(N4CCOCC4=O)c(C=O)nc32)ncc1C#N CHEMBL3964830 IC50 8.8 nM
N#Cc1cnc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)cc1OCC(F)(F)F CHEMBL3939822 IC50 8.9 nM
COc1cc(OC)cc(N(CCCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3909529 pIC50 8.913 nM
COc1cc(OC)c(C)c(N(CCCN2CCCC2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3945264 pIC50 8.913 nM
COc1cc(OC)cc(N(CCN2CCC(N(C)C)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3958708 pIC50 8.913 nM
C=CC(=O)Nc1cc(N2CCN(C)CC2)ccc1Nc1n[nH]c2ccc(O[C@H](C)c3c(Cl)cncc3Cl)cc12 CHEMBL5197977 IC50 9.0 nM
COC[C@@H]1CCCN1c1cc(NC(=O)N2CCCc3cc(CN4CCOCC4=O)c(C=O)nc32)ncc1C#N CHEMBL4441426 IC50 9.1 nM
CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CC(=O)NC)c3)nc2c1 CHEMBL3935232 pIC50 9.12 nM
COc1cc(OC)cc(N(CCCN)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3937633 pIC50 9.12 nM
CC(C)Oc1cc(NC(=O)N2CCCc3ccc(C=O)nc32)ncc1C#Cc1cccc(C#N)c1 CHEMBL5077354 IC50 9.2 nM
COc1cc(OC)cc(N(CCCN2CCC[C@H]2CC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921476 pIC50 9.333 nM
CN(C)C1CCN(c2cc(NC(=O)N3CCCc4cc(CN5CCOCC5=O)c(C=O)nc43)ncc2C#N)C1 CHEMBL4447090 IC50 9.4 nM
CO[C@H]1CCN(c2cc(NC(=O)N3CCCc4cc(CN5CCOC5=O)c(C=O)nc43)ncc2C#N)C1 CHEMBL4471404 IC50 9.5 nM
COCCNc1cc(NC(=O)N2CCCc3ccc(C=O)nc32)ncc1C#N CHEMBL5091476 IC50 9.5 nM
C=CC(=O)Nc1cnc2ccccc2c1Nc1cc2c(cn1)cc(-c1c(Cl)c(OC)cc(OC)c1Cl)c(=O)n2CC CHEMBL5181533 IC50 9.7 nM
COc1cc(OC)cc(N(CCCC#N)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3955706 pIC50 9.772 nM
COc1cc(OC)cc(N(CCNCCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3944610 pIC50 9.772 nM
COc1cc(F)cc(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1 CHEMBL3974206 pIC50 9.772 nM
COc1cc(OC)cc(N(CC#Cc2cc(C(N)=O)ccn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3921190 pIC50 9.772 nM