CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1 CHEMBL576982 GI50 0.01 nM
CCc1cc(NC(=O)Nc2ccc(-c3cnc(Nc4cc(N5CCN(CC)CC5)nc(C)n4)s3)cc2)no1 CHEMBL3593290 GI50 0.01 nM
COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cnn(C)c1 CHEMBL5176837 Kd 0.01 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4nc[nH]c34)c(F)c2)no1 CHEMBL4744130 IC50 0.015 nM
O=C1Nc2ccccc2/C1=C1/Nc2ccccc2/C1=N\OCC(=O)N1CCNCC1 CHEMBL5195819 Kd 0.0154 nM
Cc1c[nH]c(CNC(=O)c2ccc(-c3nc4ccc5[nH]ncc5c4c4c3CCCC4)cc2)n1 CHEMBL5440655 IC50 0.024 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ncnc4[nH]ncc34)c(F)c2)no1 CHEMBL4519741 IC50 0.038 nM
CC1(COc2ccc3c(c2)ncn3-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1 CHEMBL2105728 IC50 0.06 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3F)c2cc1OC CHEMBL4790915 IC50 0.072 nM
Cc1cc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(N)c34)cc2)ccc1F CHEMBL273187 pKi 0.1 nM
CCN1CCN(c2cc(Nc3ncc(-c4ccncc4)s3)nc(C)n2)CC1 CHEMBL4513768 IC50 0.1 nM
CC(=O)N1CCN(c2ccc(Nc3nccc(-c4c[nH]c5ncccc45)n3)cc2)CC1 CHEMBL4864449 Ki 0.1 nM
CC(=O)N1CCCN(c2cccc(Nc3nccc(-c4c[nH]c5ncccc45)n3)c2)CC1 CHEMBL4870188 Ki 0.1 nM
CNC(=O)[C@@]1(N)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL5268237 IC50 0.1 nM
CCc1cc2c(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCN(C)CC4)cc3)ncnc2s1 CHEMBL4086149 IC50 0.101 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)n1ccc(-c2cnn3ccc(Cl)nc23)c1 CHEMBL3612622 IC50 0.123 nM
CCN(CC)Cc1ccc(NC(=O)c2n[nH]cc2Nc2ncnc3[nH]ccc23)cc1 CHEMBL4092761 IC50 0.13 nM
CN(C(=O)c1ccccc1)[C@@H]1C[C@@]2(C)O[C@@](C)(C1)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4790597 IC50 0.15 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL373798 pKi 0.1585 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)cncc21 CHEMBL404366 pKi 0.1585 nM
CCCNc1nc(Nc2ccc(C#N)cc2)ncc1C#CCCCNC(=O)[C@H](C)N(C)C(=O)/C=C/CN(C)C CHEMBL4650283 IC50 0.16 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL3301622 IC50 0.16 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)NCCc1cnn2ccc(Cl)nc12 CHEMBL3612511 IC50 0.166 nM
Cc1csc2ncnc(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCN(C)CC4)cc3)c12 CHEMBL4078261 IC50 0.167 nM
Nc1nc(Nc2ccc([C@H]3CC[C@H](N4CCOCC4)CC3)cc2)nn1-c1ccccn1 CHEMBL1835870 Ki 0.17 nM
Cc1ccc(C#N)cc1S(=O)(=O)N(C)CCc1cnn2ccc(Cl)nc12 CHEMBL3612513 IC50 0.177 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.18 nM
O=C1Nc2ccc(F)cc2/C1=C1/Nc2ccccc2/C1=N\OCC(=O)N1CCNCC1 CHEMBL5201185 IC50 0.18 nM
Cc1nc2c(c(Nc3c[nH]nc3C(=O)Nc3ccc(N4CCNCC4)cc3)n1)CCC2 CHEMBL4163870 IC50 0.19 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4ccccc4)ccc32)c(C)c1C(=O)O CHEMBL1173107 IC50 0.2 nM
COc1nc(Nc2ncc3c4ccncc4n([C@H]4CC[C@H](C)CC4)c3n2)ccc1N1CCC(N(C)C)CC1 CHEMBL3237712 IC50 0.2 nM
CC(=O)N1CCN(c2ccc(Nc3ncc(C#N)c(-c4n[nH]c5ccccc45)n3)cc2)CC1 CHEMBL4878159 Ki 0.2 nM
O=C1Nc2ccc(Cl)cc2/C1=C1/Nc2ccccc2/C1=N\OCC(=O)N1CCNCC1 CHEMBL5188834 IC50 0.2 nM
O=C(CO/N=C1C(=C2/C(=O)Nc3ccccc32)/Nc2ccccc2/1)N[C@@H]1CCNC1 CHEMBL5188978 IC50 0.2 nM
O=C(CO/N=C1C(=C2/C(=O)Nc3ccccc32)/Nc2ccccc2/1)N[C@H]1CCNC1 CHEMBL5170345 IC50 0.2 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnn2ccc(C#N)nc12 CHEMBL3612507 IC50 0.212 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 0.22 nM
O=C1Nc2ccc(Br)cc2/C1=C1/Nc2ccccc2/C1=N\OCC(=O)N1CCNCC1 CHEMBL5209537 IC50 0.22 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCCCC1 CHEMBL124660 IC50 0.22 nM
CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4sccc34)cc2)CC1 CHEMBL4075720 Kd 0.23 nM
Cc1cc(Nc2ncc3ncc(=O)n(-c4ccc(N)cc4)c3n2)ccc1N1CCN(C)CC1 CHEMBL4550647 Kd 0.25 nM
CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1 CHEMBL4077071 IC50 0.27 nM
CCc1nc(C(N)=O)c(Cc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1CN1CCOCC1 CHEMBL5201174 IC50 0.29 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]ncc34)c(F)c2)no1 CHEMBL4749639 IC50 0.292 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2ccc(O)cc2o1 CHEMBL2032274 IC50 0.3 nM
CC1(C)CC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC(C)(C)N1 CHEMBL2206279 Kd 0.3 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 IC50 0.3 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)nc4)nc32)CC1 CHEMBL3237706 IC50 0.3 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 Kd apparent 0.3 nM
Cc1cc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ccn1 CHEMBL4515413 IC50 0.3 nM
O=C(Nc1ccc(N2CCOCC2)cc1C(F)(F)F)c1cnn2ccc(N[C@@H]3CCCNC3)nc12 CHEMBL5087138 IC50 0.3 nM
O=C(Nc1ccc(N2CCOCC2)cc1Cl)c1cnn2ccc(N[C@@H]3CCCNC3)nc12 CHEMBL5093309 IC50 0.3 nM
CN[C@H]1CC2OC([C@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(O)=NC4 CHEMBL3975634 IC50 0.32 nM
CN1CCCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4sccc34)cc2)CC1 CHEMBL4101635 IC50 0.32 nM
O=C1Nc2ccc(F)cc2/C1=C1/Nc2ccccc2/C1=N\OCCN1CCNCC1 CHEMBL4791998 IC50 0.32 nM
O=C1Nc2ccc(F)cc2/C1=C1/Nc2ccccc2/C1=N\OCCN1CCNCC1 CHEMBL1623035 IC50 0.32 nM
O=C(CCc1ccc(-c2cnc3[nH]ccc3c2)cc1)NCCNS(=O)(=O)c1ccccc1 CHEMBL4561847 pIC50 0.3236 nM
CN1CCN(c2ccc(Nc3cc(-c4cccs4)n[nH]3)cc2)CC1 CHEMBL4475689 IC50 0.327 nM
CC1=CC(=O)N(Nc2nc(-c3cccs3)nc3sc(-c4ccc(OCCNCCO)cc4)c(C)c23)C1=O CHEMBL3936771 IC50 0.334 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C(C)C)CC3)c(C)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687210 IC50 0.34 nM
O=C(Nc1ccc(CN2CCNCC2)cc1)c1n[nH]cc1Nc1ncnc2sccc12 CHEMBL4104057 IC50 0.34 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C(C)C)CC3)c(C)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL4528166 IC50 0.34 nM
COc1ccc(Nc2nccc(-c3c[nH]c4ccccc34)n2)c(OC)c1 CHEMBL4173067 Ki 0.34 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687202 IC50 0.35 nM
CCCCNc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL3326006 IC50 0.35 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL4466977 IC50 0.35 nM
CN1CCN(C(=O)CO/N=C2C(=C3/C(=O)Nc4ccc(F)cc43)/Nc3ccccc3/2)CC1 CHEMBL5202926 IC50 0.35 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1NC1CCOCC1 CHEMBL3687215 IC50 0.36 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)c(F)c2)nc1NC1CCOCC1 CHEMBL3687222 IC50 0.36 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1NC1CCOCC1 CHEMBL4580325 IC50 0.36 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)c(F)c2)nc1NC1CCOCC1 CHEMBL4461418 IC50 0.36 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 0.37 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1N[C@H]1CC[C@](C)(O)CC1 CHEMBL3687212 IC50 0.37 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C4CCN(C)CC4)CC3)c(C)c2)nc1NC1CCOCC1 CHEMBL3687225 IC50 0.37 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1N[C@H]1CC[C@](C)(O)CC1 CHEMBL4438824 IC50 0.37 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C4CCN(C)CC4)CC3)c(C)c2)nc1NC1CCOCC1 CHEMBL4591308 IC50 0.37 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)CCc1cnn2ccc(Cl)nc12 CHEMBL3612512 IC50 0.374 nM
Cc1cc2c(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCN(C)CC4)cc3)ncnc2s1 CHEMBL4073053 IC50 0.384 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1N[C@H]1CC[C@@](C)(O)CC1 CHEMBL3687207 IC50 0.39 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1N[C@H]1CC[C@@](C)(O)CC1 CHEMBL4524842 IC50 0.39 nM
CN1CCN(C(=O)CO/N=C2C(=C3/C(=O)Nc4ccc(Cl)cc43)/Nc3ccccc3/2)CC1 CHEMBL5195070 IC50 0.39 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cncc4c3c(N)nn4C)cc2)c1 CHEMBL402846 pKi 0.3981 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cncc4[nH]nc(N)c34)cc2)c1 CHEMBL272938 pKi 0.3981 nM
CCN1CCC(Cc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1 CHEMBL2203427 Kd 0.4 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccc(OC4CCN(C5CC5)CC4)cn3)cc2)no1 CHEMBL2203438 Kd 0.4 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccc(OC4CCN(C(C)(C)C)CC4)cn3)cc2)no1 CHEMBL2203437 Kd 0.4 nM
CC(=O)N1CCN(c2ccc(Nc3ncc(C#N)c(-c4c[nH]c5ccccc45)n3)cc2)CC1 CHEMBL4855435 Ki 0.4 nM
O=C(Nc1ccc(N2CCOCC2)cc1Br)c1cnn2ccc(N[C@@H]3CCCNC3)nc12 CHEMBL5090761 IC50 0.4 nM
CN1CCC(Nc2nc(Nc3ccc(Oc4ccccc4)cc3)c3c(=O)[nH]cc(Br)c3n2)CC1 CHEMBL4544478 IC50 0.4 nM
O=C(CCc1ccc(-c2cnc3[nH]ccc3c2)cc1)NCCNS(=O)(=O)c1ccc(F)cc1 CHEMBL4547323 pIC50 0.4074 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL4524472 IC50 0.41 nM
COc1cc(Nc2nc3cccc(-c4cccc(C(N)=O)c4)c3o2)ccc1N1CCNCC1 CHEMBL5287891 IC50 0.41 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 0.42 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687191 IC50 0.44 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL4441604 IC50 0.44 nM
O=C1Nc2ccc(I)cc2/C1=C1/Nc2ccccc2/C1=N\OCC(=O)N1CCNCC1 CHEMBL5170760 IC50 0.45 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687195 IC50 0.46 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL4454732 IC50 0.46 nM
N[C@H]1CC[C@@H](Nc2nc(Nc3ccc4c(c3)CCN(C(=O)CO)C4)ncc2C(F)(F)F)CC1 CHEMBL5410841 IC50 0.46 nM
CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4ccsc34)cc2)CC1 CHEMBL4061686 IC50 0.47 nM
O=C(Nc1ccc(N2CCNCC2)cc1)c1n[nH]cc1Nc1nc(Cl)nc2sccc12 CHEMBL4172223 IC50 0.47 nM
O=C(CCc1ccc(-c2cnc3[nH]ccc3c2)cc1)NCCNS(=O)(=O)c1ccccc1Cl CHEMBL4483002 pIC50 0.4786 nM
Cc1cc(F)c2[nH]ccc2c1-c1nc(C(N)=O)c(-c2ccc(N3CCNC(C)(C)C3)cc2)o1 CHEMBL3917983 IC50 0.48 nM
COc1cc(Nc2nc(NC3CCOCC3)c(C(C)C)nc2C(N)=O)ccc1N1CCN(C)CC1 CHEMBL3687223 IC50 0.49 nM
COc1cc(Nc2nc(NC3CCOCC3)c(C(C)C)nc2C(N)=O)ccc1N1CCN(C)CC1 CHEMBL4438727 IC50 0.49 nM
COc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]cc(C(=O)O)c2C)cc1 CHEMBL1173411 IC50 0.5 nM
CCN1C(C)(C)CC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1(C)C CHEMBL2206278 Kd 0.5 nM
CN1C(C)(C)CC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1(C)C CHEMBL2206277 Kd 0.5 nM
CCN1CCC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1 CHEMBL2203434 Kd 0.5 nM
COc1ccc(C(=O)NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(C(=O)NCCN3CCCC3)c2C)c(F)c1 CHEMBL3329684 IC50 0.5 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C(F)(F)F)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687200 IC50 0.5 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C(F)(F)F)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL4574005 IC50 0.5 nM
O=C(Nc1ccc(N2CCOCC2)cc1C(F)(F)F)c1cnn2ccc(N[C@@H]3CCCCNC3)nc12 CHEMBL5084405 IC50 0.5 nM
Cc1ncc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1c(N)ncc2ccc(F)cc12 CHEMBL5284731 IC50 0.5 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cncc4[nH]nc(N)c34)cc2)c1 CHEMBL271441 pKi 0.5012 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 0.51 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687194 IC50 0.51 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1NC1CCOCC1 CHEMBL3687220 IC50 0.51 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL4465661 IC50 0.51 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1NC1CCOCC1 CHEMBL4463071 IC50 0.51 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1NC1CCOCC1 CHEMBL3687224 IC50 0.52 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1NC1CCOCC1 CHEMBL4591953 IC50 0.52 nM
CN1CCN(C(=O)CO/N=C2C(=C3/C(=O)Nc4ccccc43)/Nc3ccccc3/2)CC1 CHEMBL5199328 IC50 0.52 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 0.54 nM
C=CC(=O)Nc1ccccc1Oc1nc(Nc2cnn(CCOC)c2)ncc1Cl CHEMBL3884839 IC50 0.54 nM
Cc1c[nH]c2cccc(-c3nc(C(N)=O)c(-c4ccc(N5CCNC(C)(C)C5)cc4)o3)c12 CHEMBL3945870 IC50 0.55 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1NC1CCOCC1 CHEMBL3687221 IC50 0.56 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1NC1CCOCC1 CHEMBL4483656 IC50 0.56 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 0.57 nM
O=C(c1ccc(CN2CCCCC2)cc1)N1CCc2nc(-c3cc4cc(F)ccc4[nH]c3=O)[nH]c2C1 CHEMBL2016905 IC50 0.57 nM
Cc1sc2ncnc(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCN(C)CC4)cc3)c2c1C CHEMBL4093755 IC50 0.576 nM
O=C(Nc1ccc(N2CCNCC2)cc1)c1n[nH]cc1Nc1cc(Oc2ccccc2)ncn1 CHEMBL5401158 Kd 0.58 nM
O=C(Nc1ccc(CN2CCOCC2)cc1)c1n[nH]cc1Nc1ncnc2ccccc12 CHEMBL4088753 IC50 0.588 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2cccc(-c3ccccn3)c2o1 CHEMBL2032155 IC50 0.6 nM
CC(C)N1CCC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1 CHEMBL2203435 Kd 0.6 nM
Cc1ccc(C(=O)Nc2ccc(NC(=O)Nc3cc(C(C)(C)C)on3)cc2)nc1 CHEMBL2203430 Kd 0.6 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)nc2F)CC1 CHEMBL3237711 IC50 0.6 nM
COc1nc(Nc2ncc3c4ccncc4n([C@H]4CC[C@H](C)CC4)c3n2)ccc1N1CCC2(CCC(=O)N2)CC1 CHEMBL3237718 IC50 0.6 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn(-c4ccc(OCCN5CCOCC5)cc4Cl)nn3)cc2)no1 CHEMBL4645320 GI50 0.6 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn(-c4ccc(OCCN5CCOCC5)cc4F)nn3)cc2)no1 CHEMBL4642032 GI50 0.6 nM
COc1cc(-n2cc(-c3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nn2)ccc1OCCN1CCOCC1 CHEMBL4636818 GI50 0.6 nM
CC(=O)N1CCCN(c2cccc(Nc3nccc(-c4n[nH]c5ccccc45)n3)c2)CC1 CHEMBL4867869 Ki 0.6 nM
Cc1c(NC(=O)CCNC2CCCC2)c[nH]c1/C=C1\C(=O)Nc2ccc(F)cc21 CHEMBL4868092 IC50 0.6 nM
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC CHEMBL2105717 IC50 0.6 nM
Cc1nc(Nc2c[nH]nc2C(=O)Nc2ccc(N3CCNCC3)cc2)c2ccsc2n1 CHEMBL4164331 IC50 0.62 nM
O=C(Nc1ccc(CN2CCOCC2)cc1)c1n[nH]cc1Nc1ncnc2sccc12 CHEMBL4077074 IC50 0.623 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL223360 Kd 0.63 nM
C=CC(=O)Nc1ccccc1Oc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1Cl CHEMBL3884960 IC50 0.63 nM
O=C(CO)N1CCc2nc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)ccc2C1 CHEMBL3684989 IC50 0.65 nM
Cc1nc(Nc2c[nH]nc2C(=O)Nc2ccc(CN3CCN(C)CC3)cc2)c2ccsc2n1 CHEMBL4175865 IC50 0.65 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C(F)(F)F)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687205 IC50 0.66 nM
Cc1nc(Nc2c[nH]nc2C(=O)Nc2ccc(CN3CCOCC3)cc2)c2cc(C(C)C)sc2n1 CHEMBL4171138 IC50 0.66 nM
Cc1nc2c(c(Nc3c[nH]nc3C(=O)Nc3ccc(N4CCNCC4)cc3)n1)CCCC2 CHEMBL4159478 IC50 0.66 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C(F)(F)F)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL4465573 IC50 0.66 nM
CCc1ccc(-c2nc(C(N)=O)c(-c3ccc(N4CCNC(C)(C)C4)cc3)o2)c2cc[nH]c12 CHEMBL3957869 IC50 0.67 nM
CC(C)(CO)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1 CHEMBL3645272 Kd 0.68 nM
CC(=O)c1ccc(NC(=O)N2CCN(c3nc(Nc4ccc(N5CCOCC5)cc4)ncc3Cl)CC2)cc1 CHEMBL5412815 IC50 0.68 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)cc1NC1CCOCC1 CHEMBL5173987 IC50 0.69 nM
O=C(Nc1ccc(-c2ccccc2)cc1)Nc1ccc2c(c1)NC(=O)/C2=C\c1ccc[nH]1 CHEMBL1172837 IC50 0.7 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccc(OC4CCNCC4)cn3)cc2)no1 CHEMBL2203433 Kd 0.7 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1 CHEMBL1081509 Kd 0.7 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn(-c4ccc(OCCN5CCCC5)cc4Cl)nn3)cc2)no1 CHEMBL4634001 GI50 0.7 nM
CC(=O)N1CCCN(c2cccc(Nc3nccc(-c4cnc5n(C)cccc4-5)n3)c2)CC1 CHEMBL4871011 Ki 0.7 nM
COc1ccccc1Cn1cnc2ccc(-c3cc(NC(=O)c4ccc(NC5CCN(C)CC5)cc4)n[nH]3)cc21 CHEMBL5289647 IC50 0.7 nM
Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O CHEMBL302449 IC50 0.7 nM
Cc1cc(Nc2nc(N[C@H]3CC[C@H](O)CC3)c(Cl)nc2C(N)=O)ccc1N1CCC(N2CCN(C)CC2)CC1 CHEMBL3687217 IC50 0.72 nM
Cc1cc(Nc2nc(N[C@H]3CC[C@H](O)CC3)c(Cl)nc2C(N)=O)ccc1N1CCC(N2CCN(C)CC2)CC1 CHEMBL4580299 IC50 0.72 nM
Cc1nc(Nc2c[nH]nc2C(=O)Nc2ccc(CN3CCN(C)CC3)cc2)c2cc(C(C)C)sc2n1 CHEMBL4160544 IC50 0.73 nM
Cc1n[nH]c2ccc3nc(-c4c[nH]nc4C(F)(F)F)c4c(c3c12)CCCC4 CHEMBL4856135 Kd 0.73 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4cc(C#N)cs4)n[nH]3)cc2)CC1 CHEMBL4473820 IC50 0.735 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ncccc3O)cc2)no1 CHEMBL1079545 Kd 0.74 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3nccc4ccccc34)cc2)no1 CHEMBL1080064 Kd 0.74 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccc4ccccc4c3)cc2)no1 CHEMBL1081345 Kd 0.75 nM
CN1CC(NC(=O)CO/N=C2C(=C3/C(=O)Nc4ccccc43)/Nc3ccccc3/2)C1 CHEMBL5186291 IC50 0.75 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccccn3)cc2)no1 CHEMBL1081346 Kd 0.76 nM
Cc1ccn2ncc(/C=N/N(C)S(=O)(=O)c3cc([N+](=O)[O-])ccc3C)c2n1 CHEMBL3612503 IC50 0.762 nM
Cc1ccc2sc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)cc2c1 CHEMBL1080063 Kd 0.77 nM
Cc1ccc2[nH]ccc2c1-c1nc(C(N)=O)c(-c2ccc(N3CCNC(C)(C)C3)cc2)o1 CHEMBL3970921 IC50 0.77 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3c(F)ccc4[nH]nc(N)c34)cc2)c1 CHEMBL1996255 pKi 0.7943 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)c1 CHEMBL196363 pKi 0.7943 nM
Cc1cc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)c(F)c2)ccc1F CHEMBL1986979 pKi 0.7943 nM
CC(C)(CN)CNc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1968930 pKi 0.7943 nM
CN1CCN(c2ccc(Nc3cc(-c4cc(Cl)cs4)n[nH]3)cc2)CC1 CHEMBL4571743 IC50 0.7991 nM
O=C(Nc1ccc(Oc2ccccc2)cc1)Nc1ccc2c(c1)NC(=O)/C2=C\c1ccc[nH]1 CHEMBL1172887 IC50 0.8 nM
Cc1ccnc(C(=O)Nc2ccc(NC(=O)Nc3cc(C(C)(C)C)on3)cc2)c1 CHEMBL2203429 Kd 0.8 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccccc32)c(C)c1CCC(=O)O CHEMBL274654 Kd apparent 0.8 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn(-c4ccc(OCCN5CCCCC5)cc4Cl)nn3)cc2)no1 CHEMBL4648528 GI50 0.8 nM
Cc1c(NC(=O)CCN2CCCC2)c[nH]c1/C=C1\C(=O)Nc2ccc(F)cc21 CHEMBL4869059 IC50 0.8 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 0.82 nM
CC1(C)CN(c2ccc(-c3oc(-c4ccc(F)c5[nH]ccc45)nc3C(N)=O)cc2)CCN1 CHEMBL3932362 IC50 0.821 nM
C=CS(=O)(=O)Nc1ccc2c(c1)/C(=C/c1[nH]c(C)c(C(=O)NCCN(CC)CC)c1C)C(=O)N2 CHEMBL4553725 Kd 0.83 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccc(Cl)cc2)c2ncc[nH]2)C(=O)N3)CC1 CHEMBL2086760 IC50 0.85 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5ncn(Cc6ccccc6Cl)c5c4)[nH]n3)cc2)CC1 CHEMBL5280424 IC50 0.85 nM
CC(=O)N1CCc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2C1 CHEMBL5409504 IC50 0.87 nM
COc1ccc(-c2nc(C(N)=O)c(-c3ccc(N4CCNC(C)(C)C4)cc3)o2)c2cc[nH]c12 CHEMBL3923418 IC50 0.89 nM
Cc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2ccc[nH]2)cc1 CHEMBL1172815 IC50 0.9 nM
CN1CCN(Cc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1 CHEMBL2203428 Kd 0.9 nM
Nc1nc(Nc2ccc3c(c2)CC[C@@H](N2CCCC2)CC3)nn1-c1cc2c(nn1)-c1ccccc1CCC2 CHEMBL3809489 IC50 0.9 nM
CCCCNc1ncc2c(-c3ccc(C4(N5CCN(C)CC5)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4284541 IC50 0.9 nM
CN(C)CCOc1ccc(-n2cc(-c3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nn2)c(Cl)c1 CHEMBL4639577 GI50 0.9 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn(-c4ccc(OCCN5CCOCC5)cc4)nn3)cc2)no1 CHEMBL4648063 GI50 0.9 nM
C[C@H](O)C(=O)N1CCc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2C1 CHEMBL5428756 IC50 0.92 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5ncn(Cc6cccc(Cl)c6)c5c4)[nH]n3)cc2)CC1 CHEMBL5267748 IC50 0.94 nM
Cc1ccccc1Cn1cnc2ccc(-c3cc(NC(=O)c4ccc(NC5CCN(C)CC5)cc4)n[nH]3)cc21 CHEMBL5275773 IC50 0.94 nM
Cc1nc(Nc2c[nH]nc2C(=O)Nc2ccc(N3CCN(C)CC3)cc2)c2ccsc2n1 CHEMBL4160930 IC50 0.95 nM
O=C(Nc1ccc(CN2CCOCC2)cc1)c1n[nH]cc1Nc1nc(Cl)nc2ccccc12 CHEMBL4059849 IC50 0.958 nM
CC1(C)CN(c2ccc(-c3oc(-c4ccc(Cl)c5[nH]ccc45)nc3C(N)=O)cc2)CCN1 CHEMBL3959866 IC50 0.97 nM
CCN1CCN(C(=O)c2ccc3c(c2)sc2nc(-c4ccc(NC(=O)Nc5cc(C(C)(C)C)on5)cc4)cn23)CC1 CHEMBL574575 Kd 0.98 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccccc3)cc2)no1 CHEMBL1081169 Kd 0.98 nM
CC(=O)N1CCc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc21 CHEMBL5413462 IC50 0.98 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCCN5CCOCC5)ccc34)cc2)no1 CHEMBL574349 Kd 0.99 nM
CO/N=C/c1c(N)ncnc1N1CCN(C(=O)Nc2ccc(Oc3ccccc3)cc2)CC1 CHEMBL235008 IC50 1.0 nM
CN1CCN(Cc2ccc(Nc3ncc4c(=O)c(C(N)=O)cn(-c5ccc6c(c5)CCC6)c4n3)cc2)CC1 CHEMBL256893 IC50 1.0 nM
CN1CCN(CCc2ccc(Nc3ncc4c(=O)c(C(N)=O)cn(-c5ccc6c(c5)CCC6)c4n3)cc2)CC1 CHEMBL403776 IC50 1.0 nM
c1cc(-c2cnn3cc(-c4ccc(OCCN5CCOCC5)cc4)cnc23)ccn1 CHEMBL324153 IC50 1.0 nM
Nc1cc(-c2cnn3cc(-c4ccc(OCCN5CCOCC5)cc4)cnc23)ccn1 CHEMBL1271533 IC50 1.0 nM
Oc1ccc(-c2cnn3cc(-c4ccc(OCCN5CCOCC5)cc4)cnc23)cc1O CHEMBL1271641 IC50 1.0 nM
COc1ccccc1Nc1nc(N)n(-c2cc(NCCN(C)C)ncn2)n1 CHEMBL1835746 Ki 1.0 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)c(F)c3)c12 CHEMBL2000652 pKi 1.0 nM
Cc1cc(NC(=O)Cc2ccc(-c3cccc4[nH]nc(N)c34)cc2)ccc1F CHEMBL1984363 pKi 1.0 nM
Nc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL403402 pKi 1.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)c(F)c2)c1 CHEMBL1994638 pKi 1.0 nM
CC(C)(C(N)=O)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1967720 pKi 1.0 nM
Cc1cc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)ccc1F CHEMBL374044 pKi 1.0 nM
O=C(NCc1ccc(-c2cc(NC(=O)c3ccc(OCCN4CCCC4)cc3)[nH]n2)cc1)OCc1ccccc1 CHEMBL2063324 IC50 1.0 nM
Cn1cc(Nc2ncc(Br)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)cn1 CHEMBL2071201 IC50 1.0 nM
CCN1CCC(Oc2ccnc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)c2)CC1 CHEMBL2203432 Kd 1.0 nM
O=C(Nc1ccc(Oc2ncnc3[nH]ncc23)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL2332840 IC50 1.0 nM
CC(C)(C)c1cc(NC(=O)NCc2ccc(-c3cc(NC(=O)c4ccc(OCCN5CCOCC5)cc4)[nH]n3)cc2)no1 CHEMBL2386802 IC50 1.0 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc(N5CCC(N)CC5)cn4)nc32)CC1 CHEMBL3237708 IC50 1.0 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CCN(C(=O)CO)C5)nc32)CC1 CHEMBL3237719 IC50 1.0 nM
CN1CCN(Cc2ccc(-c3cn([C@H]4CC[C@H](O)CC4)c4nc(NCCC5CC5)ncc34)cc2)CC1 CHEMBL3326007 IC50 1.0 nM
Cc1nc(Nc2ncc(-c3ccc(NC(=O)Nc4cc(C)on4)cc3)s2)cc(N2CCN(C)CC2)n1 CHEMBL3593287 GI50 1.0 nM
NCCCCNc1nc(Nc2ccc(CN3CCOCC3)cc2)c2ncn(C3CCCC3)c2n1 CHEMBL4212560 IC50 1.0 nM
CCN1CCN(c2ccc(Nc3nc(NCCCCN)nc4c3ncn4C3CCCC3)cc2)CC1 CHEMBL4207317 IC50 1.0 nM
FC(F)(F)c1n[nH]cc1-c1nc2ccc3[nH]ncc3c2c2c1CCCC2 CHEMBL4593398 IC50 1.0 nM
CN(C)c1cc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ccn1 CHEMBL4451595 IC50 1.0 nM
CC(C)Oc1cncnc1-c1ccc2nc(Nc3cc([C@@H](C)N4CCN(C(=O)CC(F)(F)F)CC4)ccn3)[nH]c2c1 CHEMBL4543618 IC50 1.0 nM
Cc1cc(-n2cc(-c3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nn2)ccc1OCCN1CCOCC1 CHEMBL4640080 GI50 1.0 nM
Cc1n[nH]c2cc(F)c3nc(-c4c[nH]nc4C(F)(F)F)c4c(c3c12)CCCC4 CHEMBL4869569 IC50 1.0 nM
COc1ccc(CNc2ccc3c(c2)ncn3-c2ccccc2)cc1OC CHEMBL5089806 Activity 1.0 nM
C[C@H]1CC[C@@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CCN(C(=O)CO)C5)nc32)CC1 CHEMBL5207533 IC50 1.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 IC50 1.0 nM
COc1ccc(-c2cnc3c(Nc4ccc(S(=O)(=O)N5CCCC5)cc4)cc(N[C@H]4CC[C@H](N)CC4)nn23)cc1 CHEMBL5393913 IC50 1.0 nM
N[C@H]1CC[C@H](Nc2cc(Nc3ccc(S(=O)(=O)N4CCCC4)cc3)c3ncc(-c4ccc(F)cc4)n3n2)CC1 CHEMBL5394415 IC50 1.0 nM
N[C@H]1CC[C@H](Nc2cc(Nc3ccc(S(=O)(=O)N4CCCC4)cc3)c3ncc(-c4ccc(O)c(F)c4)n3n2)CC1 CHEMBL5420271 IC50 1.0 nM
N#Cc1ccc(-c2cnc3c(Nc4ccc(S(=O)(=O)N5CCCC5)cc4)cc(N[C@H]4CC[C@H](N)CC4)nn23)cc1 CHEMBL5404635 IC50 1.0 nM
N[C@H]1CC[C@H](Nc2cc(Nc3ccc(S(=O)(=O)N4CCCC4)cc3)c3ncc(-c4ccsc4)n3n2)CC1 CHEMBL5394400 IC50 1.0 nM
N[C@H]1CC[C@H](Nc2cc(Nc3ccc(S(=O)(=O)N4CCCC4)cc3)c3ncc(-c4ccoc4)n3n2)CC1 CHEMBL5430571 IC50 1.0 nM
CC(C)c1cnc2c(Nc3ccc(S(=O)(=O)N4CCCC4)cc3)cc(N[C@H]3CC[C@H](N)CC3)nn12 CHEMBL5437260 IC50 1.0 nM
N[C@H]1CC[C@H](Nc2cc(Nc3ccc(S(=O)(=O)N4CCCC4)cc3)c3ncc(-c4ccccc4)n3n2)CC1 CHEMBL5436665 IC50 1.0 nM
N[C@H]1CC[C@H](Nc2cc(Nc3ccc(S(=O)(=O)N4CCCC4)cc3)c3ncc(-c4cn[nH]c4)n3n2)CC1 CHEMBL5441015 IC50 1.0 nM
O=C(Nc1ccc(CN2CCNCC2)cc1)c1n[nH]cc1Nc1ncnc2[nH]ccc12 CHEMBL4074948 IC50 1.03 nM
O=C(Nc1ccc(CNC2CC2)cc1)c1n[nH]cc1Nc1ncnc2sccc12 CHEMBL4076277 IC50 1.05 nM
N[C@H]1CC[C@@H](Nc2nc(Nc3ccc4c(c3)CN(C(=O)CO)C4)ncc2C(F)(F)F)CC1 CHEMBL5426241 IC50 1.06 nM
COc1cc2c(Oc3ccc(NC(=O)c4cc(-c5ccc(C)cc5)ccn4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL2435999 IC50 1.08 nM
O=C(CO/N=C1C(=C2/C(=O)Nc3ccc(Cl)cc32)/Nc2ccccc2/1)NC1CCNCC1 CHEMBL5186183 IC50 1.08 nM
CC(C)(O)CC(=O)N1CCc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2C1 CHEMBL5403690 IC50 1.08 nM
CCN1CCN(Cc2ccc3c(c2)sc2nc(-c4ccc(NC(=O)Nc5cc(C(C)(C)C)on5)cc4)cn23)CC1 CHEMBL581849 Kd 1.1 nM
Cc1cc(N2CCOCC2)ccc1NC(=O)c1cnn2ccc(N[C@@H]3CCCNC3)nc12 CHEMBL5086080 IC50 1.1 nM
Cc1cnc(Nc2ccc(N3CCN(C)CC3)c(F)c2)nc1Nc1ccc(S(=O)(=O)NC(C)(C)C)cc1 CHEMBL5289028 IC50 1.1 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4cccc(C)c4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL5170277 IC50 1.1 nM
O=C(CO/N=C1C(=C2/C(=O)Nc3ccccc32)/Nc2ccccc2/1)NC1CCNCC1 CHEMBL5195353 IC50 1.12 nM
CC(C)(O)CC(=O)N1Cc2ccc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)cc2C1 CHEMBL5433322 IC50 1.12 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 IC50 1.13 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5ncn(C6CCCC6)c5c4)[nH]n3)cc2)CC1 CHEMBL5288323 IC50 1.14 nM
CN1CCc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2C1=O CHEMBL5409206 IC50 1.15 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1cc2cccnc2n(-c2ccc(F)cc2)c1=O CHEMBL4289577 IC50 1.16 nM
COc1ccn2ncc(/C=N/N(C)S(=O)(=O)c3cc([N+](=O)[O-])ccc3C)c2n1 CHEMBL3612508 IC50 1.19 nM
CN1CCN(c2ccc3c(c2)sc2nc(-c4ccc(NC(=O)Nc5cc(C(C)(C)C)on5)cc4)cn23)CC1 CHEMBL575312 Kd 1.2 nM
COc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2ccc[nH]2)cc1OC CHEMBL1172814 IC50 1.2 nM
Cc1cc(CN2CCN(c3c(Br)cnc4nc(-c5ccc(N6CCN(C)CC6)cc5)[nH]c34)CC2)no1 CHEMBL1236904 Kd 1.2 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc(OC4CCNCC4)ccn3)cc2)no1 CHEMBL2203431 Kd 1.2 nM
CCCCNc1ncc2c(-c3ccc(S(=O)(=O)N4CCN(C)CC4)c(F)c3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL3326004 IC50 1.2 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3nc(OCCN5C[C@@H]6C[C@H]5CN6)ccc34)cc2)no1 CHEMBL3941340 IC50 1.2 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3F)ncnc2cn1 CHEMBL4761091 IC50 1.2 nM
CSc1cc(N2CCOCC2)ccc1NC(=O)c1cnn2ccc(N[C@@H]3CCCNC3)nc12 CHEMBL5079154 IC50 1.2 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1NC(=O)c1cnn2ccc(N[C@@H]3CCCNC3)nc12 CHEMBL5081241 IC50 1.2 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C[C@H](O)CO)c5)cnc(N)c34)cc2)cc1 CHEMBL3646211 IC50 1.22 nM
O=C1Nc2ccc(F)cc2/C1=C1/Nc2ccccc2/C1=N\OCCC(=O)N1CCNCC1 CHEMBL5185448 IC50 1.23 nM
CC(=O)N1CCc2ccc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)cc2C1 CHEMBL5421825 IC50 1.24 nM
C[C@@H](O)C(=O)N1CCc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2C1 CHEMBL5411251 IC50 1.25 nM
COc1ccc(-c2ccc(NC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2)c2c(N)noc12 CHEMBL1973178 pKi 1.259 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 pKi 1.259 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1970317 pKi 1.259 nM
NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1998432 pKi 1.259 nM
Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c12 CHEMBL1976220 pKi 1.259 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)n1ccc(-c2cnn3ccc(Cl)nc23)n1 CHEMBL3612515 IC50 1.28 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(CCC(=O)O)ccc34)cc2)no1 CHEMBL583418 Kd 1.3 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(CCCN5CCOCC5)ccc34)cc2)no1 CHEMBL584293 Kd 1.3 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2180602 IC50 1.3 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CCNC5)nc32)CC1 CHEMBL3680379 IC50 1.3 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 IC50 1.3 nM
Cc1c(NC(=O)CCN2CCCCC2)c[nH]c1/C=C1\C(=O)Nc2ccc(F)cc21 CHEMBL4851401 IC50 1.3 nM
COc1cc(N2CCOCC2)ccc1NC(=O)c1cnn2ccc(N3CCC[C@@H](N)C3)nc12 CHEMBL5076390 IC50 1.3 nM
CN1CCN(Cc2ccc(NC(=O)[C@@H]3CCN(c4ccc5ncc(-c6ccccn6)n5n4)C3)cc2C(F)(F)F)CC1 CHEMBL5421783 IC50 1.3 nM
O=S(=O)(NCCNCCCc1ccc(-c2cnc3[nH]ccc3c2)cc1)c1ccccc1 CHEMBL4452541 pIC50 1.318 nM
Cc1cc(=O)n(-c2ccc(F)cc2)nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1 CHEMBL4066684 IC50 1.32 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2[nH]ncc2c1 CHEMBL2316582 IC50 1.33 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5c(c4)OCO5)n[nH]3)cc2)CC1 CHEMBL4456471 IC50 1.336 nM
NC1CCN(C(=O)CO/N=C2C(=C3/C(=O)Nc4ccc(Cl)cc43)/Nc3ccccc3/2)CC1 CHEMBL5181917 IC50 1.34 nM
O=C(CCc1ccc(-c2cnc3[nH]ccc3c2)cc1)NCCNS(=O)(=O)c1cccc2cnccc12 CHEMBL4439659 pIC50 1.349 nM
CC(C)(O)C(=O)N1Cc2ccc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)cc2C1 CHEMBL5408927 IC50 1.35 nM
Cc1cc(C)c2[nH]ccc2c1-c1nc(C(N)=O)c(-c2ccc(N3CCNC(C)(C)C3)cc2)o1 CHEMBL3954570 IC50 1.37 nM
Cc1csc2ncnc(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCOCC4)cc3)c12 CHEMBL4080236 IC50 1.37 nM
N[C@H]1CC[C@@H](Nc2nc(Nc3ccc4c(c3)CNC4=O)ncc2C(F)(F)F)CC1 CHEMBL5086374 IC50 1.37 nM
COc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2ccc[nH]2)cc1 CHEMBL1173149 IC50 1.4 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)C(O)CNC5)nc32)CC1 CHEMBL3684984 IC50 1.4 nM
CNc1ncc2c(-c3ccc(N4CCN(C)CC4)cc3)nn(CC3CCCC3)c2n1 CHEMBL4218175 IC50 1.4 nM
Cc1c(NC(=O)CN2CCCC2)c[nH]c1/C=C1\C(=O)Nc2ccc(F)cc21 CHEMBL4862765 IC50 1.4 nM
CN1CC[C@@H](NC(=O)CO/N=C2C(=C3/C(=O)Nc4ccccc43)/Nc3ccccc3/2)C1 CHEMBL5172103 IC50 1.4 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c5c(sc4n3)CCc3c[nH]cc3-5)cc2)no1 CHEMBL5183674 IC50 1.4 nM
CC(=O)c1ccc(NC(=O)N2CCN(c3ccnc(Nc4ccc(N5CCOCC5)cc4)n3)CC2)cc1 CHEMBL4581423 IC50 1.4 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5ncn(Cc6ccsc6)c5c4)[nH]n3)cc2)CC1 CHEMBL5273185 IC50 1.42 nM
Cn1ccc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2c1=O CHEMBL5089164 IC50 1.48 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCCCC5)ccc34)cc2)no1 CHEMBL575269 Kd 1.5 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(CCC(=O)N5CCOCC5)ccc34)cc2)no1 CHEMBL574526 Kd 1.5 nM
O=C(Nc1ccc(-c2ccc3ccccc3c2)cc1)Nc1ccc2c(c1)NC(=O)/C2=C\c1ccc[nH]1 CHEMBL1172838 IC50 1.5 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 1.5 nM
CCN1CCC(c2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1 CHEMBL2203426 Kd 1.5 nM
CCCCNc1ncc2c(-c3ccc(N4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4283152 IC50 1.5 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn(-c4ccc(OCCCN5CCOCC5)cc4Cl)nn3)cc2)no1 CHEMBL4642718 GI50 1.5 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn(-c4ccc(OCCN5CCOCC5)cc4)nn3)c(F)c2)no1 CHEMBL4642927 GI50 1.5 nM
Cc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1Nc1ccc(S(=O)(=O)NC(C)(C)C)cc1 CHEMBL5281221 IC50 1.5 nM
CC(C)(O)CC(=O)N1CCc2cc(Nc3ncc(C(F)(F)F)c(NCCCCN)n3)ccc2C1 CHEMBL5439334 IC50 1.5 nM
CN1CCN(c2ccc(Nc3cc(-c4ccc(Cl)s4)n[nH]3)cc2)CC1 CHEMBL4461271 IC50 1.503 nM
COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3F)c2cc1OC CHEMBL4781811 IC50 1.51 nM
O=C(Nc1cc(-c2ccc3c(c2)OCO3)n[nH]1)c1ccc(N2CCNCC2)cc1 CHEMBL4459133 IC50 1.518 nM
CC(C)(O)C(=O)N1CCc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2C1 CHEMBL5431016 IC50 1.53 nM
CC1(C)CN(c2ccc(-c3oc(-c4cccc5[nH]ccc45)nc3C(N)=O)cc2)CCN1 CHEMBL3956504 IC50 1.54 nM
CCc1cc2c(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCOCC4)cc3)ncnc2s1 CHEMBL4075723 IC50 1.56 nM
Cc1ccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)cc1 CHEMBL2005828 pKi 1.585 nM
Cc1cc(NC(=O)Nc2ccc(-c3c(F)ccc4[nH]nc(N)c34)cc2)ccc1F CHEMBL1993996 pKi 1.585 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3nsc4ncnc(N)c34)cc2)c1 CHEMBL262433 pKi 1.585 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc1)CCN2 CHEMBL411903 pKi 1.585 nM
Cc1cccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)c1 CHEMBL1983963 pKi 1.585 nM
CN1CCN(Cc2ccc3c(c2)Cc2c(-c4csc(C#CCOCC5CC5)c4)n[nH]c2-3)CC1 CHEMBL2002446 pKi 1.585 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 1.585 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)ccnc21 CHEMBL1985888 pKi 1.585 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)csc12 CHEMBL2005631 pKi 1.585 nM
CN1CCN(C2CCC(n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1997617 pKi 1.585 nM
O=C(CCc1ccc(-c2cnc3[nH]ccc3c2)cc1)NCCNS(=O)(=O)c1cccc([N+](=O)[O-])c1 CHEMBL4569083 pIC50 1.585 nM
COc1cc(O)c2c(c1)CCC[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O CHEMBL2012519 IC50 1.59 nM
CCn1ccc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2c1=O CHEMBL5438311 IC50 1.59 nM
CC(C)OCc1ccc2c(c1)c1c3c(c4c(c1n2CCCO)Cc1ccccc1-4)C(=O)NC3 CHEMBL150894 IC50 1.6 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cn4c(n3)sc3ccccc34)cc2)no1 CHEMBL575925 Kd 1.6 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(C(=O)O)ccc34)cc2)no1 CHEMBL584710 Kd 1.6 nM
CC(CO)(CO)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1 CHEMBL3645273 Kd 1.6 nM
CC(=O)N1Cc2ccc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)nc2[C@H](C)C1 CHEMBL3684986 IC50 1.6 nM
COc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\OCC(=O)N1CCNCC1)C(=O)N2 CHEMBL5169874 IC50 1.61 nM
O=C1Nc2ccc(OC(F)(F)F)cc2/C1=C1/Nc2ccccc2/C1=N\OCC(=O)N1CCNCC1 CHEMBL5200813 IC50 1.62 nM
CC(=O)N1Cc2ccc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)cc2C1 CHEMBL5439250 IC50 1.63 nM
O=S(=O)(NCCNCCCc1ccc(-c2cnc3[nH]ccc3c2)cc1)c1cccc2cnccc12 CHEMBL4577991 pIC50 1.66 nM
CN1CCN(CCCOc2ccc3c(c2)sc2nc(-c4ccc(NC(=O)Nc5cc(C(C)(C)C)on5)cc4)cn23)CC1 CHEMBL574039 Kd 1.7 nM
COCCN1CCc2nc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)ccc2C1 CHEMBL3684978 IC50 1.7 nM
Cc1c(NC(=O)CCN(C)C)c[nH]c1/C=C1\C(=O)Nc2ccc(F)cc21 CHEMBL4877838 IC50 1.7 nM
CCCNCCC(=O)Nc1c[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL4860305 IC50 1.7 nM
CN1CCN(c2ccc(Nc3cc(-c4cc(Br)cs4)n[nH]3)cc2)CC1 CHEMBL4513662 IC50 1.711 nM
COc1ccc(-c2cc(Nc3ccc(N4CCN(C)CC4)cc3)[nH]n2)s1 CHEMBL4522701 IC50 1.711 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CCN(CCO)C5)nc32)CC1 CHEMBL3680381 IC50 1.8 nM
CC1CNCc2ccc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)nc21 CHEMBL3684981 IC50 1.8 nM
Cc1c(NC(=O)CCNC(C)(C)C)c[nH]c1/C=C1\C(=O)Nc2ccc(F)cc21 CHEMBL4853071 IC50 1.8 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cn[nH]c5)cnc(N)c34)cc2)c1 CHEMBL1969102 IC50 1.81 nM
COc1ccc(S(=O)(=O)NCCNC(=O)CCc2ccc(-c3cnc4[nH]ccc4c3)cc2)cc1 CHEMBL4448577 pIC50 1.82 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5ncn(Cc6ccccc6)c5c4)[nH]n3)cc2)CC1 CHEMBL5198364 IC50 1.84 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(/C=C/c3ccccc3)n2)n[nH]1 CHEMBL482968 IC50 1.86 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3ccccc34)cc2)no1 CHEMBL578024 Kd 1.9 nM
O=C(Nc1ccc(Cl)cc1)Nc1ccc2c(c1)NC(=O)/C2=C\c1ccc[nH]1 CHEMBL1172886 IC50 1.9 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)n1cc(-c2cnn3ccc(Cl)nc23)cn1 CHEMBL3612514 IC50 1.9 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 1.9 nM
COc1cc(N2CCNCC2)ccc1NC(=O)c1cnn2ccc(N3CCC[C@@H](N)C3)nc12 CHEMBL5087597 IC50 1.9 nM
O=C(CCc1ccc(-c2cnc3[nH]ccc3c2)cc1)NCCNS(=O)(=O)c1cccc(Cl)c1 CHEMBL4574698 pIC50 1.905 nM
CN1CC[C@H](NC(=O)CO/N=C2C(=C3/C(=O)Nc4ccccc43)/Nc3ccccc3/2)C1 CHEMBL5181019 IC50 1.91 nM
CC1(C)CN(c2ccc(-c3oc(-c4c(F)ccc5[nH]ccc45)nc3C(N)=O)cc2)CCN1 CHEMBL3944825 IC50 1.92 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)(C)O)c5)cnc(N)c34)cc2)cc1 CHEMBL2004290 IC50 1.93 nM
COc1csc(-c2cc(Nc3ccc(N4CCN(C)CC4)cc3)[nH]n2)c1 CHEMBL4435445 IC50 1.96 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1998585 pKi 1.995 nM
CCc1cccc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1968406 pKi 1.995 nM
Cn1cc(-c2cnn3c(N)c(-c4ccc(NC(=O)Nc5cccc(C(F)(F)F)c5)cc4)cnc23)cn1 CHEMBL1988717 pKi 1.995 nM
Cc1cccc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1242373 pKi 1.995 nM
Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 CHEMBL394790 pKi 1.995 nM
Cc1ccc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)cc1 CHEMBL374330 IC50 2.0 nM
Nc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)c12 CHEMBL255955 IC50 2.0 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc1)CCN2 CHEMBL260092 IC50 2.0 nM
CCN1C(=O)C(C)(C)c2cc3[nH]c4c(c3cc21)CCCc1c(C)n[nH]c1-4 CHEMBL223147 IC50 2.0 nM
CCN1CCN(C(=O)CCc2ccc3c(c2)sc2nc(-c4ccc(NC(=O)Nc5cc(C(C)(C)C)on5)cc4)cn23)CC1 CHEMBL574576 Kd 2.0 nM
CNC(=O)c1ncc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(CCO)CC4)c(C(F)(F)F)c3)ccc2C)n1C CHEMBL1784637 IC50 2.0 nM
CN1CCC(c2ccc(Nc3nc(N)n(-c4ccccn4)n3)cc2)CC1 CHEMBL1835867 Ki 2.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 2.0 nM
COc1cccc(NC(=O)Cn2cc(Oc3ncnc4cc(OC)c(OC)cc34)cn2)c1 CHEMBL1940108 IC50 2.0 nM
COCCOc1cc2ncnc(Oc3cnn(CC(=O)Nc4cccc(OC)c4)c3)c2cc1OC CHEMBL1940109 IC50 2.0 nM
Cc1cc2oc(-c3cc(-c4cnn(C5CCNCC5)c4)cnc3N)nc2cc1O CHEMBL2032276 IC50 2.0 nM
Cc1cc(-c2cc(NC(=O)c3ccc(CN4CCN(C)CC4)cc3)[nH]n2)ccc1NC(=O)Nc1cc(C(C)(C)C)on1 CHEMBL2386796 IC50 2.0 nM
COCCOc1ccn2c(-c3ccc4cccc(OC5CCNCC5)c4n3)cnc2c1 CHEMBL3109340 IC50 2.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCCC3)c2cn1 CHEMBL3237451 IC50 2.0 nM
CC1CCC(n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)CC1 CHEMBL3237702 IC50 2.0 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)CC1 CHEMBL3237703 IC50 2.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)nc2)CC1 CHEMBL3237709 IC50 2.0 nM
CCN1CCN(c2cc(Nc3ncc(-c4ccc(NC(=O)Nc5cc(C6CC6)on5)cc4)s3)nc(C)n2)CC1 CHEMBL3593292 GI50 2.0 nM
CN(C)CCCn1cc(-c2ccc3c(c2)-c2[nH]c4cc(-c5cn[nH]c5)ccc4c2C3=O)cn1 CHEMBL3815054 IC50 2.0 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CCN(CCCO)C5)nc32)CC1 CHEMBL3680382 IC50 2.0 nM
Cc1cc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(C)c34)cc2)ccc1N1CCOCC1 CHEMBL4072731 IC50 2.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(N4CCOCC4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4208701 IC50 2.0 nM
CCN1CCN(c2ccc(Nc3nc(N[C@H]4CC[C@H](N)CC4)nc4c3ncn4C3CCCC3)cc2)CC1 CHEMBL4203825 IC50 2.0 nM
C[C@]1(CO)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL4469622 IC50 2.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ncnc4[nH]ncc34)c(Cl)c2)no1 CHEMBL4444648 IC50 2.0 nM
CC(=O)N1CCN(c2ccc(Nc3nccc(-c4cn(C)c5ncccc45)n3)cc2)CC1 CHEMBL4876697 Ki 2.0 nM
CN1CCN(c2cccc(Nc3nccc(-c4c[nH]c5ncccc45)n3)c2)CC1 CHEMBL4862206 Ki 2.0 nM
CC(=O)N1CCN(c2ccc(Nc3ncc(C#N)c(-c4c(C)[nH]c5ccccc45)n3)cc2)CC1 CHEMBL4856641 Ki 2.0 nM
Cc1c(NC(=O)CN(C)C)c[nH]c1/C=C1\C(=O)Nc2ccc(F)cc21 CHEMBL4866775 IC50 2.0 nM
CCN(CC)CCC(=O)Nc1c[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL4864382 IC50 2.0 nM
N#Cc1cc(N2CCOCC2)ccc1NC(=O)c1cnn2ccc(N[C@@H]3CCCNC3)nc12 CHEMBL5083401 IC50 2.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc4ncccc4c3)c(F)c2)ccn1 CHEMBL1738757 IC50 2.0 nM
NC(=O)c1ccc(Nc2nc(N[C@H]3CC[C@H](N)CC3)nc3c2ncn3C2CCCC2)cc1 CHEMBL5188322 IC50 2.0 nM
N[C@H]1CC[C@H](Nc2cc(Nc3ccc(S(=O)(=O)N4CCCC4)cc3)c3ncc(Br)n3n2)CC1 CHEMBL5412366 IC50 2.0 nM
COc1cccc(-c2cnc3c(Nc4ccc(S(=O)(=O)N5CCCC5)cc4)cc(N[C@H]4CC[C@H](N)CC4)nn23)c1 CHEMBL5429138 IC50 2.0 nM
COc1ccc(-c2cnc3c(Nc4ccc(S(=O)(=O)N5CCCC5)cc4)cc(N[C@H]4CC[C@H](N)CC4)nn23)cc1OC CHEMBL5426549 IC50 2.0 nM
N[C@H]1CC[C@H](Nc2cc(Nc3ccc(S(=O)(=O)N4CCCC4)cc3)c3ncc(C4CCCC4)n3n2)CC1 CHEMBL5438877 IC50 2.0 nM
CC(C)Cc1cnc2c(Nc3ccc(S(=O)(=O)N4CCCC4)cc3)cc(N[C@H]3CC[C@H](N)CC3)nn12 CHEMBL5416037 IC50 2.0 nM
Cc1cnc2c(Nc3ccc(S(=O)(=O)N4CCCC4)cc3)cc(N[C@H]3CC[C@H](N)CC3)nn12 CHEMBL5399463 IC50 2.0 nM
CN1CCN(c2ccc(Nc3cc(-c4ccc(C#N)s4)n[nH]3)cc2)CC1 CHEMBL4457695 IC50 2.006 nM
Cc1ccc(S(=O)(=O)NCCNCCCc2ccc(-c3cnc4[nH]ccc4c3)cc2)cc1 CHEMBL4444839 pIC50 2.042 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1nnn(-c2ccc(F)cc2)c1C(F)(F)F CHEMBL3774451 IC50 2.06 nM
O=C(Nc1ccc(CN2CCOCC2)cc1)c1n[nH]cc1Nc1ncnc2[nH]ccc12 CHEMBL4103390 IC50 2.06 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5ccn(Cc6ccccc6)c5c4)[nH]n3)cc2)CC1 CHEMBL5278798 IC50 2.06 nM
NC1CCN(C(=O)CO/N=C2C(=C3/C(=O)Nc4ccccc43)/Nc3ccccc3/2)CC1 CHEMBL5182954 IC50 2.07 nM
CC(C)Oc1cc(-n2cnc3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 CHEMBL2151321 IC50 2.1 nM
COc1ccc(NC(=O)CC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(C(=O)NCCN3CCCC3)c2C)cc1 CHEMBL3322566 IC50 2.1 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3545311 IC50 2.1 nM
COc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\OCCN1CCN(C)CC1)C(=O)N2 CHEMBL4093032 IC50 2.1 nM
CN1Cc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2C1=O CHEMBL5087845 IC50 2.1 nM
CC(C)(O)CC(=O)N1CCc2ccc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)cc2C1 CHEMBL5427417 IC50 2.11 nM
Cc1ccc(S(=O)(=O)NCCNC(=O)CCc2ccc(-c3cnc4[nH]ccc4c3)cc2)cc1 CHEMBL4562391 pIC50 2.138 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(Cl)c5ccccc5n(-c5ccc(F)cc5)c4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3780676 IC50 2.15 nM
O=C(CO/N=C1C(=C2/C(=O)Nc3ccc(F)cc32)/Nc2ccccc2/1)NC1CCNCC1 CHEMBL5169937 IC50 2.16 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C[C@H](C)O)c5)cnc(N)c34)cc2)c1 CHEMBL3646210 IC50 2.18 nM
CCCNC(=O)c1cc(Oc2ccc(NC(=O)c3cc4cccnc4n(-c4ccc(F)cc4)c3=O)cc2)ccn1 CHEMBL4204920 IC50 2.18 nM
CC(C)c1c2cc(-c3ccnc(Nc4ccc5c(N6CCN(C)CC6)ccnc5c4)n3)ccc2nn1C CHEMBL4856177 IC50 2.2 nM
CC(C)(O)C(=O)N1CCc2ccc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)cc2C1 CHEMBL5427282 IC50 2.21 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3ccc(OCCN5CCOCC5)cc34)cc2)no1 CHEMBL567839 Kd 2.3 nM
O=C(Nc1ccccc1)Nc1ccc2c(c1)NC(=O)/C2=C\c1ccc[nH]1 CHEMBL1173482 IC50 2.3 nM
Cc1nc(Nc2nc3ccc(-c4cccc(C(=O)Nc5cccc(C(F)(F)F)c5)c4)nc3s2)cc(N2CCNCC2)n1 CHEMBL2148120 Kd 2.3 nM
CC(=O)N1Cc2ccc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)nc2[C@@H](C)C1 CHEMBL3684994 IC50 2.3 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn(-c4ccc(OCCN5CCOCC5)cc4Br)nn3)cc2)no1 CHEMBL4647116 GI50 2.3 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc3oc(C(=O)c4cc5cc(O)ccc5[nH]4)cc3c2)no1 CHEMBL4745937 IC50 2.3 nM
CC(C)c1cc2c(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCN(C)CC4)cc3)ncnc2s1 CHEMBL4096307 IC50 2.31 nM
C=CCn1cc(-c2ccc(NC(=O)Nc3cc(C(C)(C)C)on3)cc2)c2c(N)ncnc21 CHEMBL4439404 Kd 2.37 nM
NC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(N[C@H]3CC[C@@H](O)CC3)n2)cc1 CHEMBL5088179 IC50 2.39 nM
COc1ccc(S(=O)(=O)NCCNCCCc2ccc(-c3cnc4[nH]ccc4c3)cc2)cc1 CHEMBL4454962 pIC50 2.399 nM
O=C(CCc1ccc(-c2cnc3[nH]ccc3c2)cc1)NCCNS(=O)(=O)c1ccc(Cl)cc1 CHEMBL4593660 pIC50 2.399 nM
Cc1cc(CN2CCN(c3c(Cl)cnc4[nH]c(-c5cn(C)nc5C)nc34)CC2)no1 CHEMBL2207518 Kd 2.4 nM
Cc1c(NC(=O)C2CCCCN2)c[nH]c1/C=C1\C(=O)Nc2ccc(F)cc21 CHEMBL4846119 IC50 2.4 nM
CN(C)CCn1cc(-c2ccn3c(-c4ccc(C(N)=O)s4)cnc3c2)cn1 CHEMBL4863351 IC50 2.4 nM
Cc1cc(Nc2ncc(C(F)(F)F)c(N[C@H]3CC[C@@H](N)CC3)n2)ccc1C(N)=O CHEMBL5082524 IC50 2.47 nM
CC1=CC(=O)N(Nc2nc(-c3cccs3)nc3sc(-c4ccc(OCCNCC(C)C)cc4)c(C)c23)C1=O CHEMBL3899727 IC50 2.495 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cccc(O)n3)cc2)no1 CHEMBL1079544 Kd 2.5 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCCNC(=O)[C@@H](N)CCCC4)cc2)CC1 CHEMBL3964573 IC50 2.5 nM
CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4283353 IC50 2.5 nM
Cc1c(NC(=O)[C@@H]2CCCN2)c[nH]c1/C=C1\C(=O)Nc2ccc(F)cc21 CHEMBL4861526 IC50 2.5 nM
CCNCCC(=O)Nc1c[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL4862737 IC50 2.5 nM
COc1cc2c(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCCCC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL5197792 Kd 2.5 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN)cnc(N)c34)cc2)c1 CHEMBL1965988 pKi 2.512 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4c3c(N)nn4C)cc2)c1 CHEMBL1985491 pKi 2.512 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cncc4c3c(N)nn4C)cc2)c1 CHEMBL404367 pKi 2.512 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4ccc(F)c(C(F)(F)F)c4)cc3)ccnc21 CHEMBL1966836 pKi 2.512 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3cccc4onc(N)c34)cc2)c1 CHEMBL409349 pKi 2.512 nM
O=C(Nc1ccc(N2CCNCC2)cc1)c1n[nH]cc1Nc1nc(C2CC2)nc2sccc12 CHEMBL4172658 IC50 2.53 nM
NC1CCN(C(=O)CO/N=C2C(=C3/C(=O)Nc4ccc(F)cc43)/Nc3ccccc3/2)CC1 CHEMBL5202099 IC50 2.54 nM
CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4occc34)cc2)CC1 CHEMBL4103338 IC50 2.56 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@@H](N[C@H](Cc2ccccc2)C(=O)O)CC1 CHEMBL4210294 IC50 2.6 nM
CC(C)(O)Cn1ncc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2c1=O CHEMBL5424522 IC50 2.69 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(O)ccc34)cc2)no1 CHEMBL575307 Kd 2.7 nM
COc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(CCC(=O)O)c2C)cc1 CHEMBL1173541 IC50 2.7 nM
COc1ccc(C(=O)NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(CCC(=O)O)c2C)cc1 CHEMBL3329669 IC50 2.7 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4cc5c(cn4)CCN(CCO)C5)nc32)CC1 CHEMBL3684980 IC50 2.7 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1NC(=O)[C@H]1CCCN1 CHEMBL4093614 IC50 2.7 nM
O=C1Nc2ccccc2/C1=C1/Nc2ccccc2/C1=N\OCCN1CCNCC1 CHEMBL4781746 IC50 2.7 nM
Cc1c(NC(=O)CC2CCCN2)c[nH]c1/C=C1\C(=O)Nc2ccc(F)cc21 CHEMBL4865208 IC50 2.7 nM
Cc1c(NC(=O)CN2CCN(C)CC2)c[nH]c1/C=C1\C(=O)Nc2ccc(F)cc21 CHEMBL4868929 IC50 2.7 nM
COc1cc(N2CCOCC2)ccc1NC(=O)c1cnn2ccc(N[C@@H]3CCCNC3)nc12 CHEMBL5083766 IC50 2.7 nM
CCOc1cc(N2CCOCC2)ccc1NC(=O)c1cnn2ccc(N[C@@H]3CCCNC3)nc12 CHEMBL5093203 IC50 2.7 nM
O=C(c1ccncc1)N1CCc2nc(-c3cc4cc(F)ccc4[nH]c3=O)[nH]c2C1 CHEMBL2016903 IC50 2.7 nM
O=C1Nc2ccc(F)cc2/C1=C1/Nc2ccccc2/C1=N\OCS(=O)(=O)N1CCNCC1 CHEMBL5201194 IC50 2.71 nM
CCN1CCN(c2ccc(C(=O)Nc3cc(-c4ccc5c(c4)OCO5)n[nH]3)cc2)CC1 CHEMBL4469023 IC50 2.773 nM
COc1ccc(Nc2nc(N)n(-c3ccccn3)n2)cc1OC CHEMBL1835740 Ki 2.8 nM
CC1(C)CN(c2ccc(-c3oc(-c4ccc(C(F)(F)F)c5[nH]ccc45)nc3C(N)=O)cc2)CCN1 CHEMBL3928949 IC50 2.8 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn(-c4ccc(OCCN5CCOCC5)c(Cl)c4)nn3)cc2)no1 CHEMBL4646054 GI50 2.8 nM
CC(C)(O)CC(=O)N1CCc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc21 CHEMBL5419654 IC50 2.88 nM
O=C1Nc2ccccc2/C1=C1/Nc2ccccc2/C1=N\OCCC(=O)N1CCNCC1 CHEMBL5187737 IC50 2.89 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)C(O)CN(CCO)C5)nc32)CC1 CHEMBL3684985 IC50 2.9 nM
COc1cc(N2CCC(N3CCOCC3)CC2)ccc1NC(=O)c1cnn2ccc(N[C@@H]3CCCNC3)nc12 CHEMBL5091826 IC50 2.9 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 CHEMBL375670 IC50 3.0 nM
Cc1ccccc1NC(=O)Nc1ccc(-c2cccc3[nH]nc(N)c23)cc1 CHEMBL376077 IC50 3.0 nM
CO/N=C/c1c(N)ncnc1N1CCN(C(=O)Nc2ccc(N3CCCC3)cc2)CC1 CHEMBL401046 IC50 3.0 nM
CN1CCN(c2ccc(Nc3ncc4c(=O)c(C(N)=O)cn(-c5ccc6c(c5)CCC6)c4n3)cc2)CC1 CHEMBL414001 IC50 3.0 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cccc(C(F)(F)F)c3F)cc1)CCN2 CHEMBL410731 IC50 3.0 nM
COc1cc2ncnc(Oc3cnn(CC(=O)Nc4ccc(N(C)C)cn4)c3)c2cc1OC CHEMBL1940107 IC50 3.0 nM
COCCOc1cc2c(Oc3cnn(CC(=O)Nc4cccc(OC)c4)c3)ncnc2cc1OC CHEMBL1940110 IC50 3.0 nM
COCCOc1ccn2c(-c3ccc4cccc(O[C@@H]5CCNC[C@H]5F)c4n3)cnc2c1 CHEMBL3109337 IC50 3.0 nM
CC1(C)CCCC(n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)C1 CHEMBL3237705 IC50 3.0 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc(N5CCC6(CCC(=O)N6)CC5)cn4)nc32)CC1 CHEMBL3237717 IC50 3.0 nM
CN1CCN(S(=O)(=O)c2ccc(-c3cn([C@H]4CC[C@H](O)CC4)c4nc(NCCC5CC5)ncc34)c(F)c2)CC1 CHEMBL3326005 IC50 3.0 nM
CCCCNc1ncc2c(-c3ccc(S(=O)(=O)N4CCOCC4)cc3)nn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL3326002 IC50 3.0 nM
CCN1CCN(c2cc(Nc3ncc(-c4ccc(NC(=O)OCc5ccccc5)cc4)s3)nc(C)n2)CC1 CHEMBL3593294 GI50 3.0 nM
CCc1cc(NC(=O)Nc2ccc(-c3cnc(Nc4cc(N5CCC(N)C5)nc(C)n4)s3)cc2)no1 CHEMBL3593291 GI50 3.0 nM
CCc1cc(NC(=O)Nc2ccc(-c3cnc(Nc4cc(N5CCN(C)CC5)nc(C)n4)s3)cc2)no1 CHEMBL3593288 GI50 3.0 nM
CN(C)CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3745919 GI50 3.0 nM
NCCC(Nc1cccc(-c2cnc3c(N[C@H]4CC[C@H](N)CC4)nccn23)n1)c1ccccc1 CHEMBL3656375 IC50 3.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(N4CCCC4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4210745 IC50 3.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(CN4CCOCC4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4204373 IC50 3.0 nM
Cc1cc(-c2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)c2c(N)onc2n1 CHEMBL4247248 IC50 3.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn(-c4ccc(OCCN5CCOCC5)cc4)nn3)c(Cl)c2)no1 CHEMBL4635636 GI50 3.0 nM
COC(=O)c1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\OCCN1CCNCC1)C(=O)N2 CHEMBL4781229 IC50 3.0 nM
Cc1c(NC(=O)CCN2CCN(C)CC2)c[nH]c1/C=C1\C(=O)Nc2ccc(F)cc21 CHEMBL4857231 IC50 3.0 nM
FC(F)(F)c1n[nH]cc1-c1nc2ccc3[nH]ncc3c2c2c1CCCCC2 CHEMBL4866768 IC50 3.0 nM
FC(F)(F)c1n[nH]cc1-c1nc2ccc3[nH]nc(Br)c3c2c2c1CCCC2 CHEMBL4853855 IC50 3.0 nM
OCc1n[nH]c2ccc3nc(-c4c[nH]nc4C(F)(F)F)c4c(c3c12)CCCC4 CHEMBL4871182 IC50 3.0 nM
NCCCCNC(=O)c1ccc(Nc2nc(N[C@H]3CC[C@H](N)CC3)nc3c2ncn3C2CCCC2)cc1 CHEMBL5176691 IC50 3.0 nM
COC(=O)c1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\OCCN1CCNCC1)C(=O)N2 CHEMBL5200264 IC50 3.0 nM
CCCCNc1ncc2c(-c3ccc(S(=O)(=O)N4CCOCC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL3326003 IC50 3.0 nM
C[C@]12O[C@@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL2367481 IC50 3.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc3oc(C(=O)c4cc5cc(OC(=O)N6CCC(N7CCCCC7)CC6)ccc5[nH]4)cc3c2)no1 CHEMBL4765060 IC50 3.03 nM
CCOc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3F)c2cc1OCC CHEMBL4763034 IC50 3.08 nM
CC1CN(CCO)Cc2ccc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)nc21 CHEMBL3684983 IC50 3.1 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@@H](N[C@@H](Cc2ccccc2)C(=O)O)CC1 CHEMBL4204499 IC50 3.1 nM
COc1ccc(-c2ccn3ncc(/C=N/N(C)S(=O)(=O)c4cc([N+](=O)[O-])ccc4C)c3n2)cc1OC CHEMBL3612504 IC50 3.12 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4cc(C(N)=O)cs4)[nH]n3)cc2)CC1 CHEMBL4519177 IC50 3.12 nM
Nc1ncnc2onc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)c12 CHEMBL213505 pKi 3.162 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)c(F)c2)c1 CHEMBL1988778 pKi 3.162 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)c(F)c3)c12 CHEMBL1980904 pKi 3.162 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1967531 pKi 3.162 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 3.162 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL220057 pKi 3.162 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CC(C)(C)N)cnc(N)c34)cc2)c1 CHEMBL1979577 pKi 3.162 nM
N#Cc1ccc2nc(N)n(-c3nc(-c4ccccc4)cs3)c2c1 CHEMBL1996066 pKi 3.162 nM
O=C(Nc1ccc(Oc2cc(NC(=O)C3CC3)ncn2)cc1)Nc1ccc(CN2CCn3ccnc3C2)c(C(F)(F)F)c1 CHEMBL4746916 pIC50 3.162 nM
CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4ccccc34)cc2)CC1 CHEMBL4071450 IC50 3.17 nM
COc1cc(Nc2ncc3ncc(=O)n(-c4ccc(N)cc4)c3n2)ccc1N1CCN(C)CC1 CHEMBL4516233 IC50 3.19 nM
CC(C)(O)CC(=O)N1CCc2cc(Nc3ncc(C(F)(F)F)c(NCCCCCN)n3)ccc2C1 CHEMBL5431718 IC50 3.19 nM
CC(=O)N1CCc2nc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)ccc2C1 CHEMBL3680380 IC50 3.2 nM
CC(=O)N1Cc2ccc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)nc2C(C)C1 CHEMBL3684982 IC50 3.2 nM
C[C@]12O[C@H](C[C@H](O)[C@H]1O)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4=O CHEMBL4444272 Kd 3.2 nM
CN1CCN(c2ccc(Nc3cc(-c4ccc(C(N)=O)s4)n[nH]3)cc2)CC1 CHEMBL4469054 IC50 3.212 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL4765203 IC50 3.22 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5ncn(Cc6cccc(F)c6)c5c4)[nH]n3)cc2)CC1 CHEMBL5287778 IC50 3.22 nM
O=C(CO/N=C1C(=C2/C(=O)Nc3ccccc32)/Nc2ccccc2/1)NC1CNC1 CHEMBL5196786 IC50 3.25 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CCN(C(=O)C(=O)O)C5)nc32)CC1 CHEMBL3680383 IC50 3.3 nM
CN1CCN(CCO/N=C2C(=C3/C(=O)Nc4ccc(F)cc43)/Nc3ccccc3/2)CC1 CHEMBL4779016 IC50 3.3 nM
CC(C)(N)CCNc1nc(Nc2ccc3c(c2)CCN(C(=O)CC(C)(C)O)C3)ncc1C(F)(F)F CHEMBL5415961 IC50 3.32 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccc(OC4CCN(CC(F)(F)F)CC4)cn3)cc2)no1 CHEMBL2203436 Kd 3.4 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CCN(CCF)C5)nc32)CC1 CHEMBL3680386 IC50 3.4 nM
CCCCNc1ncc2c(-c3ccc(NC4CCNCC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4291006 IC50 3.4 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4cc(C)nc(C)c4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4877347 IC50 3.4 nM
CCc1nc(Nc2c[nH]nc2C(=O)Nc2ccc(N3CCNCC3)cc2)c2ccsc2n1 CHEMBL4162003 IC50 3.42 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)cc5)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3309402 IC50 3.49 nM
COc1cc(N(C)CCN(C)C)ccc1NC(=O)c1cnn2ccc(N[C@@H]3CCCNC3)nc12 CHEMBL5075546 IC50 3.5 nM
Cc1sc2ncnc(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCOCC4)cc3)c2c1C CHEMBL4073283 IC50 3.52 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5ncn(C6CC6)c5c4)[nH]n3)cc2)CC1 CHEMBL5279911 IC50 3.58 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5ncn(Cc6ccc(Cl)cc6)c5c4)[nH]n3)cc2)CC1 CHEMBL5270580 IC50 3.59 nM
Nc1ccc2nc(-c3cc(-c4cnn(C5CCNCC5)c4)cnc3N)oc2c1 CHEMBL2032285 IC50 3.6 nM
CC(C)Nc1ccnc(Nc2cccc(-c3cccnc3)c2)n1 CHEMBL5282138 Kd 3.6 nM
Cc1nc(Nc2c[nH]nc2C(=O)Nc2ccc(CN3CCOCC3)cc2)c2ccsc2n1 CHEMBL4168002 IC50 3.63 nM
COc1cc(N2CCN(C)CC2)ccc1NC(=O)c1cnn2ccc(N3CCC[C@@H](N)C3)nc12 CHEMBL5072265 IC50 3.7 nM
Cc1cc(C(=O)Nc2cc(-c3ccc4ncn(Cc5ccccc5)c4c3)[nH]n2)ccc1NC1CCN(C)CC1 CHEMBL5277795 IC50 3.72 nM
CC1=CC(=O)N(Nc2nc(-c3cccs3)nc3sc(-c4ccc(OC5CCNC5)cc4)c(C)c23)C1=O CHEMBL3954358 IC50 3.769 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5ncn(Cc6ccccc6)c5c4)[nH]n3)cc2F)CC1 CHEMBL5270690 IC50 3.77 nM
COc1ccc2ncnc(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCOCC4)cc3)c2c1 CHEMBL4075466 IC50 3.78 nM
O=C1Nc2ccccc2/C1=C1/Nc2ccccc2/C1=N\OCS(=O)(=O)N1CCNCC1 CHEMBL5207101 IC50 3.78 nM
CC(C)(O)CC(=O)N1CCc2cc(Nc3ncc(C(F)(F)F)c(NCCCN)n3)ccc2C1 CHEMBL5412757 IC50 3.79 nM
Cc1nc(Nc2c[nH]nc2C(=O)Nc2ccc(N3CCOCC3)cc2)c2ccsc2n1 CHEMBL4168869 IC50 3.8 nM
CC(C)(O)CC(=O)N1CCc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](NS(C)(=O)=O)CC4)n3)ccc2C1 CHEMBL5432385 IC50 3.8 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5ncn(CC6CCCCC6)c5c4)[nH]n3)cc2)CC1 CHEMBL5277875 IC50 3.86 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5ncn([C@H]6CC[C@H](N)CC6)c5c4)[nH]n3)cc2)CC1 CHEMBL5289832 IC50 3.88 nM
NC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(N[C@H]3CC[C@@H](N)CC3)n2)cc1 CHEMBL5090728 IC50 3.89 nM
CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1 CHEMBL215152 Kd 3.9 nM
COc1cc(N2CCN(S(C)(=O)=O)CC2)ccc1NC(=O)c1cnn2ccc(N3CCC[C@@H](N)C3)nc12 CHEMBL5075169 IC50 3.9 nM
CC(C)(O)Cn1ccc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2c1=O CHEMBL5395135 IC50 3.91 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 3.981 nM
Cc1cccc(NC(=O)Cc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL1964307 pKi 3.981 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C(C)C(=O)N(C)C)c5)cnc(N)c34)cc2)cc1 CHEMBL2001485 pKi 3.981 nM
CNCC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1996980 pKi 3.981 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4[nH]ncc34)cc2)c1 CHEMBL375284 pKi 3.981 nM
Cc1ccc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1988075 pKi 3.981 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(C=Cc3ccccc3)n2)n[nH]1 CHEMBL1983923 pKi 3.981 nM
COc1ccc(CNc2cc(-c3c[nH]c4ncccc34)cc(F)n2)cc1 CHEMBL1986855 pKi 3.981 nM
Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL231209 pKi 3.981 nM
COc1cc(Nc2ncc(C(F)(F)F)c(N[C@H]3CC[C@@H](N)CC3)n2)ccc1C(N)=O CHEMBL5082298 IC50 3.99 nM
Nc1noc2cccc(-c3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c12 CHEMBL406660 IC50 4.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3cccc4onc(N)c34)cc2)cc1 CHEMBL272645 IC50 4.0 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1cccn(-c2ccc(F)cc2)c1=O CHEMBL509101 IC50 4.0 nM
COc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(CC(=O)O)c2C)cc1 CHEMBL1173150 IC50 4.0 nM
Oc1ccc(-c2ccc3c(-c4ccc(N5CCNCC5)cc4)n[nH]c3n2)cc1 CHEMBL1910893 IC50 4.0 nM
COc1cc2ncnc(Nc3cnn(CC(=O)Nc4cccc(F)c4)c3)c2cc1OC CHEMBL1940103 IC50 4.0 nM
COc1cc2ncnc(Nc3cnn(CC(=O)Nc4ccc(N(C)C)cc4)c3)c2cc1OC CHEMBL1940105 IC50 4.0 nM
CCn1cc(NC(=O)Cn2cc(Oc3ncnc4cc(OC)c(OC)cc34)cn2)cn1 CHEMBL1940116 IC50 4.0 nM
CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)cn1 CHEMBL1940273 IC50 4.0 nM
CCc1cc2oc(-c3cc(-c4cnn(C5CCNCC5)c4)cnc3N)nc2cc1O CHEMBL2032278 IC50 4.0 nM
Cc1nc(Nc2cc(-c3ccc(CNC(=O)OCc4cccnc4)cc3)n[nH]2)cc(N2CCN(C)CC2)n1 CHEMBL2063336 IC50 4.0 nM
O=C(Nc1ccc(Oc2ncnc3[nH]ncc23)cc1)Nc1cccc(C(F)(F)F)c1 CHEMBL2331570 IC50 4.0 nM
CN1CCN(Cc2ccc(C(=O)Nc3cc(-c4ccc(CNC(=O)Nc5cc(C(C)(C)C)on5)cc4)n[nH]3)cc2)CC1 CHEMBL2386803 IC50 4.0 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ccc6c5)c4c3)cc2)CC1 CHEMBL2436978 IC50 4.0 nM
COCCOc1ccn2c(-c3ccc4cccc(O[C@@H]5CCNC[C@@H]5F)c4n3)cnc2c1 CHEMBL3109356 IC50 4.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)nn2)CC1 CHEMBL3237710 IC50 4.0 nM
CN1CCN(C2CCN(C(=O)Nc3cc(Oc4ccc(NC(=O)C5(C(=O)Nc6ccc(F)cc6)CC5)c(F)c4)ccn3)CC2)CC1 CHEMBL3039525 Kd apparent 4.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(Br)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4216401 IC50 4.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(N4CC5(COC5)C4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4216043 IC50 4.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(N4CCOCC4)nc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4213717 IC50 4.0 nM
NCCCCNc1nc(Nc2ccc(N3CCOCC3)cc2)c2ncn(C3CCCC3)c2n1 CHEMBL4202430 IC50 4.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cc(C)nc4noc(N)c34)cc2)c1 CHEMBL4243470 IC50 4.0 nM
Cc1cnc(Nc2ccc(N3CCC(N(C)CCO)CC3)c(F)c2)nc1-c1cnn(C(C)C)c1 CHEMBL4447631 IC50 4.0 nM
CN1CCN(Cc2ccc(NC(=O)CCSc3ccc4c(/C=C/c5ccccn5)n[nH]c4c3)cc2C(F)(F)F)CC1 CHEMBL4439424 GI50 4.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3c[nH]c4ncnc(N)c34)cc2F)no1 CHEMBL4551114 IC50 4.0 nM
CCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4cc(OC)c(OC)cc34)c(F)c1)c(C)n2C CHEMBL4571241 Kd 4.0 nM
CC(=O)N1CCN(c2ccc(Nc3nccc(-c4c[nH]c5cccnc45)n3)cc2)CC1 CHEMBL4862054 Ki 4.0 nM
CCc1c(C)c(-c2c[nH]nc2C(F)(F)F)nc2ccc3[nH]ncc3c12 CHEMBL4869214 IC50 4.0 nM
NCCCCNc1ccc(Nc2nc(N[C@H]3CC[C@H](N)CC3)nc3c2ncn3C2CCCC2)cc1 CHEMBL5198461 IC50 4.0 nM
NCCCNCCCCNC(=O)c1ccc(Nc2nc(N[C@H]3CC[C@H](N)CC3)nc3c2ncn3C2CCCC2)cc1 CHEMBL5189978 IC50 4.0 nM
N[C@H]1CC[C@H](Nc2cc(Nc3ccc(S(=O)(=O)N4CCCC4)cc3)c3ncc(-c4ccc(C(F)(F)F)cc4)n3n2)CC1 CHEMBL5415809 IC50 4.0 nM
N[C@H]1CC[C@H](Nc2cc(NC3CCC(S(=O)(=O)N4CCCC4)CC3)c3ncc(C4=CCCCC4)n3n2)CC1 CHEMBL5421975 IC50 4.0 nM
N[C@H]1CC[C@H](Nc2cc(Nc3ccc(S(=O)(=O)N4CCCC4)cc3)c3ncc(C4=CCCC4)n3n2)CC1 CHEMBL5435762 IC50 4.0 nM
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL4116008 IC50 4.0 nM
CC(C)(O)CC(=O)N1CCc2cc(Nc3ncc(C(F)(F)F)c(N[C@@H]4CCCNC4)n3)ccc2C1 CHEMBL5430670 IC50 4.03 nM
O=C(CCc1ccc(-c2cnc3[nH]ccc3c2)cc1)NCCNS(=O)(=O)c1ccc(Cl)c(Cl)c1 CHEMBL4437436 pIC50 4.074 nM
N[C@H]1CC[C@@H](Nc2nc(Nc3ccc4c(=O)n(CC5CC5)ccc4c3)ncc2C(F)(F)F)CC1 CHEMBL5088717 IC50 4.09 nM
CCN(CC)CCOc1ccc(/C=C2\C(=O)Nc3ccc(Cl)cc32)cc1 CHEMBL2206008 IC50 4.1 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn(-c4ccc(OCCN5CCOCC5)cc4)nn3)cc2F)no1 CHEMBL4634275 GI50 4.2 nM
Cn1ncc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2c1=O CHEMBL5433221 IC50 4.22 nM
O=C(CCc1ccc(-c2cnc3[nH]ccc3c2)cc1)NCCNS(=O)(=O)c1cccc(C(F)(F)F)c1 CHEMBL4460907 pIC50 4.266 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 Kd 4.3 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(N[C@H]3CC[C@@H](N)CC3)n2)cc1 CHEMBL5092253 IC50 4.31 nM
O=S(=O)(NCCNCCCc1ccc(-c2cnc3[nH]ccc3c2)cc1)c1ccc(Cl)cc1 CHEMBL4457348 pIC50 4.365 nM
COc1cc(O)c2c(c1)-c1cccc(c1)[C@@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O CHEMBL4453304 IC50 4.37 nM
Cc1nn(C)cc1-c1nc2c(N3CCN(Cc4ncon4)CC3)c(Cl)cnc2[nH]1 CHEMBL2207500 Kd 4.4 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)NC(=O)c4ccc(OC)cc4F)ccc32)c1C CHEMBL3329683 IC50 4.4 nM
CN1CCN(c2ccc(C(=O)Nc3cc(-c4ccc5c(c4)OCO5)n[nH]3)cc2)CC1 CHEMBL4533224 IC50 4.434 nM
CC(C)(O)Cn1cnc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2c1=O CHEMBL5433344 IC50 4.56 nM
N[C@H]1CC[C@@H](Nc2nc(Nc3ccc(NC(=O)C4CC4)cc3)ncc2C(F)(F)F)CC1 CHEMBL5069893 IC50 4.58 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5ncn(Cc6ccc(F)cc6)c5c4)[nH]n3)cc2)CC1 CHEMBL5287986 IC50 4.58 nM
Cn1cc(-c2nc(N[C@@H]3CCCC[C@@H]3N)c(F)c3c2C(=O)NC3)cn1 CHEMBL3979920 IC50 4.6 nM
CC(=O)N1CCN(c2ccc(Nc3ncc(C(F)(F)F)c(N4Cc5cccc(N(C)S(C)(=O)=O)c5C4)n3)cc2)CC1 CHEMBL4476226 IC50 4.6 nM
COCCOc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3F)c2cc1OC CHEMBL4763828 IC50 4.73 nM
CC(=O)Nc1ccc(Nc2ncc(C(F)(F)F)c(N[C@H]3CC[C@@H](N)CC3)n2)cc1 CHEMBL5086431 IC50 4.74 nM
Oc1ccc(Nc2nc(NCCc3ccncc3)ncc2-c2nnc(C3CC3)o2)cc1 CHEMBL486949 IC50 4.8 nM
CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ccnc4ccc(Br)cc34)cc2)CC1 CHEMBL4067804 IC50 4.84 nM
CCCNc1nc(NCCc2ccncc2)ncc1-c1nnc(C2CC2)o1 CHEMBL470163 IC50 4.9 nM
COc1cc(O)c2c(c1)/C=C/C[C@@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O CHEMBL1668411 IC50 4.9 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 4.9 nM
COCCOc1cc2c(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3F)ccnc2cc1OC CHEMBL4791482 IC50 4.91 nM
CN(C)C(=O)c1ccc(Nc2ncc(C(F)(F)F)c(N[C@H]3CC[C@@H](N)CC3)n2)cc1 CHEMBL5092606 IC50 4.95 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5ncn(-c6ccccc6)c5c4)[nH]n3)cc2)CC1 CHEMBL5290855 IC50 4.96 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5c(c4)ncn5Cc4ccccc4)[nH]n3)cc2)CC1 CHEMBL5290123 IC50 4.96 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccsc4)cc3)c12 CHEMBL376307 IC50 5.0 nM
Nc1noc2cccc(-c3ccc(NC(=O)Nc4cccc([N+](=O)[O-])c4)cc3)c12 CHEMBL272183 IC50 5.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cnc4c(-c5cnn(C)c5)ccn4c3N)cc2)c1 CHEMBL453057 IC50 5.0 nM
Cc1cc(/C=C2\C(=O)Nc3ccc(F)c(F)c32)c2ccccc(OCCCN(C)C)c1-2 CHEMBL1258711 IC50 5.0 nM
CCN(Cc1cc(Nc2nc(C)cn3c(-c4cn[nH]c4)cnc23)sn1)C(C)(C)CO CHEMBL1650533 IC50 5.0 nM
CNc1nccc(-c2c[nH]c(=O)c(NC(=O)c3ccc(N4CCCCC4)cc3)c2)n1 CHEMBL1738829 Ki 5.0 nM
Nc1nc(Nc2ccc(N3CCOCC3)cc2)nn1-c1ccccn1 CHEMBL1835747 Ki 5.0 nM
Nc1nc(Nc2ccc(C(=O)NCCN3CCOCC3)cc2)nn1-c1ccccn1 CHEMBL1835749 Ki 5.0 nM
CC(=O)N1CCC(c2ccc(Nc3nc(N)n(-c4ccccn4)n3)cc2)C1 CHEMBL1835869 Ki 5.0 nM
Nc1nc(Nc2ccc([C@H]3CC[C@@H](N4CCOCC4)CC3)cc2)nn1-c1ccccn1 CHEMBL1835871 Ki 5.0 nM
COc1cccc(NC(=O)Cn2cc(Oc3ncnc4cc(OCCN5CCCC5)c(OC)cc34)cn2)c1 CHEMBL1940112 IC50 5.0 nM
COc1cccc(NC(=O)Cn2cc(Oc3ncnc4cc(OC)cc(OC)c34)cn2)c1 CHEMBL1940113 IC50 5.0 nM
CCc1cc(NC(=O)Cc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)n[nH]1 CHEMBL1940268 IC50 5.0 nM
Cc1nc(Nc2cc(-c3ccc(CNC(=O)OCc4cc(C)on4)cc3)n[nH]2)cc(N2CCN(C)CC2)n1 CHEMBL2063337 IC50 5.0 nM
O=C(Nc1ccc(Oc2ncnc3[nH]ncc23)cc1)Nc1ccc(C(F)(F)F)cc1 CHEMBL2332849 IC50 5.0 nM
Clc1nccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c12 CHEMBL3237444 IC50 5.0 nM
O[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)CC1 CHEMBL3237450 IC50 5.0 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc(N5CCC6(CC5)CCS(=O)(=O)C6)nn4)nc32)CC1 CHEMBL3237716 IC50 5.0 nM
CC(C)C[C@@H](N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3746945 GI50 5.0 nM
N[C@H]1CC[C@@H](Nc2cc[nH]c(=O)c2-c2nc3ccccc3[nH]2)CC1 CHEMBL3780091 IC50 5.0 nM
FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1 CHEMBL3813873 IC50 5.0 nM
CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1 CHEMBL3545085 Kd apparent 5.0 nM
COc1ccc(Nc2nccc(-c3sc(N(C)C)nc3C)n2)c(OC)c1 CHEMBL4162390 Ki(app) 5.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@@H](N[C@@H](Cc2ccc(O)cc2)C(=O)O)CC1 CHEMBL4214689 IC50 5.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@@H](N[C@H](Cc2ccc(O)cc2)C(=O)O)CC1 CHEMBL4218162 IC50 5.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(Cl)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4207535 IC50 5.0 nM
NCCCCCNc1nc(Nc2ccc(CN3CCOCC3)cc2)c2ncn(C3CCCC3)c2n1 CHEMBL4213103 IC50 5.0 nM
CCN(CCO)Cc1cc(Nc2nc(C)cn3c(-c4cn[nH]c4)cnc23)sn1 CHEMBL4228240 IC50 5.0 nM
Cc1cn2c(-c3cn[nH]c3)cnc2c(Nc2cc(C(NC(C)(C)C)c3ccccn3)ns2)n1 CHEMBL4225923 IC50 5.0 nM
Cc1cc(-c2ccc(NC(=O)Nc3cccc(Cl)c3)cc2)c2c(N)onc2n1 CHEMBL4237289 IC50 5.0 nM
CCNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O CHEMBL1097999 IC50 5.0 nM
COCc1cc(-c2ccc3nc(Nc4cc([C@@H](C)N5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 CHEMBL4566796 IC50 5.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccccc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL3084839 IC50 5.0 nM
COC(=O)c1c(-c2ccc(NC(=O)Nc3ccccc3)cc2)c2c(N)ncnn2c1C CHEMBL1977041 pKi 5.012 nM
Nc1n[nH]c2cc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)ccc12 CHEMBL1997623 pKi 5.012 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN(C)C)cnc(N)c34)cc2)c1 CHEMBL1979883 pKi 5.012 nM
CCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccc(C(=O)Nc6ccccc6F)c5)nc5ccccn45)n3)cc2)CC1 CHEMBL1981725 pKi 5.012 nM
Cc1cc(C)c(C=C2C(=O)Nc3ccccc32)[nH]1 CHEMBL2002702 pKi 5.012 nM
Cc1ccccc1NC(=O)Nc1ccc(-c2coc3ncnc(N)c23)cc1 CHEMBL1984586 pKi 5.012 nM
Cc1nn(C)cc1-c1nc2c(N3CCN(Cc4ccc(Cl)cc4)CC3)c(Cl)cnc2[nH]1 CHEMBL2207503 Kd 5.1 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnc2ccc(Br)cn12 CHEMBL393525 IC50 5.15 nM
COCCOc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3F)c2cc1OCCOC CHEMBL4750430 IC50 5.17 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cccc(OCCN5CCOCC5)c34)cc2)no1 CHEMBL577406 Kd 5.2 nM
CCOc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3F)c2cc1OC CHEMBL4795857 IC50 5.2 nM
CN1CCN(c2ccc(Nc3ncc4ncc(=O)n(-c5ccc(N)cc5)c4n3)cc2Cl)CC1 CHEMBL4589511 IC50 5.24 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1NC(=O)[C@@H]1CCCN1 CHEMBL4066041 IC50 5.3 nM
COc1cc2c(Oc3ccc(NC(=O)c4cc5cccnc5n(-c5ccc(F)cc5)c4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4279457 IC50 5.31 nM
CCN(CC)Cc1ccc(NC(=O)c2n[nH]cc2Nc2ncnc3sccc23)cc1 CHEMBL4093906 IC50 5.36 nM
Cc1cc(CN2CCN(c3c(Cl)cnc4[nH]c(-c5cccc(N6CCN(C)CC6)c5)nc34)CC2)no1 CHEMBL2203775 Kd 5.4 nM
CN1CCN(C(=O)c2ccc(NC(=O)c3csc4c(=O)[nH]cnc34)c(-c3ccccc3)c2)CC1 CHEMBL3823127 IC50 5.4 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCC(O)CCCCC4)cc2)CC1 CHEMBL3976261 IC50 5.4 nM
Nc1nccc(COc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2Cl)c1Cl CHEMBL4798601 Kd 5.4 nM
O=C(Nc1ccc(N2CCOCC2)cc1C(F)(F)F)c1cnn2ccc(N[C@@H]3CCNC3)nc12 CHEMBL5073952 IC50 5.5 nM
Cc1nc(CN2CCN(c3c(Cl)cnc4[nH]c(-c5cn(C)nc5C)nc34)CC2)no1 CHEMBL2207501 Kd 5.6 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)on1 CHEMBL4743669 IC50 5.6 nM
CN1CCN(CCO/N=C2C(=C3/C(=O)Nc4ccc(OC(F)(F)F)cc43)/Nc3ccccc3/2)CC1 CHEMBL4795997 IC50 5.62 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5ncn(C6CCOCC6)c5c4)[nH]n3)cc2)CC1 CHEMBL5270966 IC50 5.73 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3F)c2cc1OCCCN1CCOCC1 CHEMBL4749484 IC50 5.77 nM
Cc1nn(C)cc1-c1nc2c(N3CCN(Cc4cncnc4)CC3)c(Cl)cnc2[nH]1 CHEMBL2207504 Kd 5.9 nM
Nc1noc2cccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 CHEMBL271600 IC50 6.0 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cccc(Cl)c3)cc1)CCN2 CHEMBL409872 IC50 6.0 nM
CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(C4CCN(C)CC4)cc3)ncc2c1=O CHEMBL492809 IC50 6.0 nM
CNc1cc(-c2c[nH]c(=O)c(NC(=O)c3ccc(N4CCCCC4)cc3)c2)ccn1 CHEMBL1765774 Ki 6.0 nM
Cc1nc(Nc2cc(-c3cccc(NS(=O)(=O)c4ccccc4)c3)n[nH]2)cc(N2CCN(C)CC2)n1 CHEMBL1807483 IC50 6.0 nM
COc1ccc(N2CCOCC2)cc1Nc1nc(N)n(-c2ccccn2)n1 CHEMBL1833992 Ki 6.0 nM
C#Cc1cccc(NC(=O)Nc2nnc(Sc3ncnc4cc(OCCCN5CCOCC5)ccc34)s2)c1 CHEMBL2046884 IC50 6.0 nM
CN1CCN(c2ccc(C(=O)Nc3cc(-c4ccc(CNC(=O)OCc5ccccc5)cc4)n[nH]3)cc2)CC1 CHEMBL2063323 IC50 6.0 nM
C1=N/C2=N/c3ccc(OCCN4CCCC4)c(c3)COC/C=C/COCc3cccc(c3)C(=C1)N2 CHEMBL2035187 IC50 6.0 nM
COc1cc2cc(c1OCCN1CCCC1)COCC=CCOCc1cccc(c1)-c1ccnc(n1)N2 CHEMBL2181087 IC50 6.0 nM
Cc1cc(NC(=O)Nc2ccc(-c3cc(NC(=O)c4ccc(N5CCN(C)CC5)cc4)[nH]n3)cc2)no1 CHEMBL2386788 IC50 6.0 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)nn4)nc32)CC1 CHEMBL3237707 IC50 6.0 nM
C[C@@H](O)CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)nn2)CC1 CHEMBL3237713 IC50 6.0 nM
CN(C)CCCn1cc(-c2ccc3c(c2)C(=O)c2c-3[nH]c3cc(-c4cn[nH]c4)ccc23)cn1 CHEMBL3814908 IC50 6.0 nM
N[C@H]1CC[C@H](Nc2nccn3c(-c4cccc(NCc5ccccc5)n4)cnc23)CC1 CHEMBL3656369 IC50 6.0 nM
N[C@H]1CC[C@H](Nc2nccn3c(-c4cccc(NCc5cccs5)n4)cnc23)CC1 CHEMBL3656381 IC50 6.0 nM
Clc1ccccc1CNc1nccc(-c2cnc3c(NCCN4CCOCC4)nccn23)n1 CHEMBL3656382 IC50 6.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(N4CCN(Cc5ccccc5)CC4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4217517 IC50 6.0 nM
CNc1cc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 CHEMBL4594167 IC50 6.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3c[nH]c4ncnc(N)c34)cc2)no1 CHEMBL4517711 IC50 6.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn(CCC#N)c4ncnc(N)c34)cc2)no1 CHEMBL4435457 IC50 6.0 nM
Cc1cc(NC(=O)Nc2cc(C(C)(C)C)on2)ccc1Oc1ncnc2[nH]ncc12 CHEMBL4448466 IC50 6.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ncnc4[nH]ncc34)cc2F)no1 CHEMBL4514229 IC50 6.0 nM
NCCCNCCCCNc1ccc(Nc2nc(N[C@H]3CC[C@H](N)CC3)nc3c2ncn3C2CCCC2)cc1 CHEMBL5172816 IC50 6.0 nM
N[C@H]1CC[C@H](Nc2cc(Nc3ccc(S(=O)(=O)N4CCCC4)cc3)c3ncc(C4CCCCC4)n3n2)CC1 CHEMBL5416952 IC50 6.0 nM
CN1CCN(c2ccc(Nc3ncc4ncc(=O)n(-c5cccc(N)c5)c4n3)cc2)CC1 CHEMBL4572416 IC50 6.13 nM
O=C(Nc1ccc(CN2CCOCC2)cc1)c1n[nH]cc1Nc1ncnc2ccsc12 CHEMBL4077278 IC50 6.15 nM
COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4ccc(F)cc4)C(C)(C)C)cc3F)c2cc1OC CHEMBL4779315 IC50 6.15 nM
N[C@H]1CC[C@@H](Nc2nc(Nc3ccc4c(=O)n(CCO)ccc4c3)ncc2C(F)(F)F)CC1 CHEMBL5087888 IC50 6.2 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCNCC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL5075192 IC50 6.25 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCC(O)CCCCC4)cc2)CC1 CHEMBL3938180 IC50 6.3 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCNS(C)(=O)=O)cnc(N)c34)cc2)c1 CHEMBL1994321 pKi 6.31 nM
Nc1ncnc2sc(Br)c(-c3ccc(NC(=O)Cc4cccc(Cl)c4)cc3)c12 CHEMBL1980896 pKi 6.31 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ccnc(N)c34)cc2)c1 CHEMBL394619 pKi 6.31 nM
NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1973720 pKi 6.31 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCOCC5)cnc(N)c34)cc2)c1 CHEMBL1982465 pKi 6.31 nM
CC(C)OC1=NNC(=O)C1=Cc1c[nH]c2ccccc12 CHEMBL1989029 pKi 6.31 nM
COc1ccc(NC(=O)CC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(C(=O)O)c2C)cc1 CHEMBL3322565 IC50 6.4 nM
CC1=CC(=O)N(Nc2nc(-c3cccs3)nc3sc(-c4ccc(OCCN5CCCC5)cc4)c(C)c23)C1=O CHEMBL3945656 IC50 6.427 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL1240703 Kd 6.5 nM
CC(C)N1CCN(c2ccc(Nc3ncc4cc5n(c4n3)C3(CCCCC3)CNC5=O)nc2)CC1 CHEMBL3904602 Kd 6.5 nM
CO[C@]1(C(=O)N[C@@H](C)c2ccc(-n3cc(F)cn3)nc2)CC[C@H](c2nc(C)cc(Nc3cc(C)[nH]n3)n2)CC1 CHEMBL4582651 IC50 6.5 nM
N[C@H]1CC[C@@H](Nc2nc(Nc3ccc4c(=O)[nH]ccc4c3)ncc2C(F)(F)F)CC1 CHEMBL5080125 IC50 6.5 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1c(N)ncc2ccc(Cl)cc12 CHEMBL5269280 IC50 6.5 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 6.6 nM
CCCCNc1ncc2c(C3CCN(C(=O)c4cc(C)nc(C)c4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4866538 IC50 6.6 nM
O=C(Nc1ccc(N2CCOCC2)cc1C(F)(F)F)c1cnn2ccc(NC3CCNCC3)nc12 CHEMBL5086288 IC50 6.7 nM
Cn1cc2c(c1)-c1c(sc3nc(-c4ccc(NC(=O)Nc5cc(C(C)(C)C)on5)cc4)cn13)CC2 CHEMBL5206333 IC50 6.7 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCC(O)CCCC4)cc2)CC1 CHEMBL3932614 IC50 6.8 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc3c(c2)sc2nc(-c4ccc(OCCN5CCOCC5)cc4)cn23)on1 CHEMBL4749162 IC50 6.83 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3F)c2cc1OC(C)C CHEMBL4782974 IC50 6.88 nM
O=C(CCc1ccc(-c2cnc3[nH]ccc3c2)cc1)NCCNS(=O)(=O)c1cc(Cl)cc(Cl)c1 CHEMBL4460767 pIC50 6.918 nM
Nc1noc2cccc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL411725 IC50 7.0 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3ccc(F)c(C(F)(F)F)c3)cc1)CCN2 CHEMBL429516 IC50 7.0 nM
Cc1cccc(S(=O)(=O)Nc2cccc(-c3cc(NC(=O)c4ccc(N5CCN(C)CC5)cc4)[nH]n3)c2)c1 CHEMBL1807469 IC50 7.0 nM
O=C(Nc1cc(-c2cccc(NS(=O)(=O)c3ccccc3)c2)n[nH]1)c1ccc(OCCN2CCCC2)cc1 CHEMBL1807478 IC50 7.0 nM
Nc1nc(Nc2ccc(C(O)CCCN3CCOCC3)cc2)nn1-c1ccccn1 CHEMBL1835750 Ki 7.0 nM
COc1cccc(NC(=O)Cc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)c1 CHEMBL1940259 IC50 7.0 nM
COc1cc2ncnc(Oc3ccc(CC(=O)Nc4cnn(C(C)C)c4)cc3)c2cc1OC CHEMBL1940274 IC50 7.0 nM
COc1cc2ncnc(Sc3nccs3)c2cc1OC CHEMBL2046699 IC50 7.0 nM
CN1CCN(c2ccc(C(=O)Nc3cc(-c4ccc(NC(=O)OCc5ccccc5)cc4)n[nH]3)cc2)CC1 CHEMBL2063319 IC50 7.0 nM
CN1CCN(Cc2ccc(C(=O)Nc3cc(-c4ccc(CNC(=O)OCc5ccccc5)cc4)n[nH]3)cc2)CC1 CHEMBL2063325 IC50 7.0 nM
NCC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3746946 GI50 7.0 nM
COc1ccc(Nc2nccc(-c3sc(SCCN(C)C)nc3C)n2)c(OC)c1 CHEMBL4167646 Ki(app) 7.0 nM
Cn1cc(-c2ccc(NC(=O)Nc3cc(C(C)(C)C)on3)cc2)c2c(N)ncnc21 CHEMBL4557634 IC50 7.0 nM
CCn1cc(-c2ccc(NC(=O)Nc3cc(C(C)(C)C)on3)cc2)c2c(N)ncnc21 CHEMBL4572972 IC50 7.0 nM
CC(=O)N1CCN(c2ccc(Nc3ncc(C#N)c(-c4cn(C)c5ccccc45)n3)cc2)CC1 CHEMBL4866028 Ki 7.0 nM
Cc1n[nH]cc1-c1nc2c(F)cc3[nH]ncc3c2c2c1CCCC2 CHEMBL4876559 IC50 7.0 nM
O=C(Nc1ccc(N2CCOCC2)cc1C(F)(F)F)c1cnn2ccc(N[C@H]3CN4CCC3CC4)nc12 CHEMBL5081841 IC50 7.0 nM
COc1cc(N2CCCC2)ccc1NC(=O)c1cnn2ccc(N[C@@H]3CCCNC3)nc12 CHEMBL5072454 IC50 7.1 nM
NC(=O)c1cc(N2CCOCC2)ccc1NC(=O)c1cnn2ccc(N[C@@H]3CCCNC3)nc12 CHEMBL5087689 IC50 7.2 nM
CCOc1cc2c(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3F)ccnc2cc1OC CHEMBL4765096 IC50 7.25 nM
COCC/C(=N\S(=O)(=O)Cc1ccc(Cl)cc1)Nc1ccc(Oc2ccnc3cc(OCCCN4CCOCC4)c(OC)cc23)c(F)c1 CHEMBL4799113 IC50 7.28 nM
CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ccncn3)cc2)CC1 CHEMBL5399420 IC50 7.29 nM
Cc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(C(=O)O)c2C)cc1 CHEMBL1172420 IC50 7.3 nM
CN1CCC(NC(=O)CO/N=C2C(=C3/C(=O)Nc4ccc(F)cc43)/Nc3ccccc3/2)CC1 CHEMBL5182860 IC50 7.31 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(C(=O)Nc3ccccc3)cc2)no1 CHEMBL1081510 Kd 7.4 nM
O=S(=O)(NCCNCCCc1ccc(-c2cnc3[nH]ccc3c2)cc1)c1ccc(Cl)c(Cl)c1 CHEMBL4445274 pIC50 7.413 nM
NC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(N[C@H]3CC[C@H](O)CC3)n2)cc1 CHEMBL5085950 IC50 7.42 nM
CC1(COc2ccc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)cc2)COC1 CHEMBL5397030 IC50 7.42 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnn2ccc(-c3cccnc3)nc12 CHEMBL3612505 IC50 7.48 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCC(O)CCC4)cc2)CC1 CHEMBL3910520 IC50 7.5 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5ncn(C)c5c4)[nH]n3)cc2)CC1 CHEMBL5286906 IC50 7.59 nM
CC(C)c1cc2c(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCOCC4)cc3)ncnc2s1 CHEMBL4099013 IC50 7.63 nM
CC(C)n1cnc2ccc(-c3cc(NC(=O)c4ccc(NC5CCN(C)CC5)cc4)n[nH]3)cc21 CHEMBL5287938 IC50 7.65 nM
O=C(Nc1ccc(N2CCNCC2)cc1)c1n[nH]cc1Nc1cc(OC2CCCC2)ncn1 CHEMBL5435746 IC50 7.84 nM
O=C1Nc2ccc(C(=O)O)cc2/C1=C1/Nc2ccccc2/C1=N\O CHEMBL5184847 IC50 7.89 nM
C1=C/Cn2ccc3ccc(cc32)-c2ccnc(n2)Nc2ccc(OCCN3CCCC3)c(c2)COC/1 CHEMBL2035049 IC50 7.9 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4nc(N)nc(N)c34)cc2)c1 CHEMBL1973145 pKi 7.943 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCCC5)cnc(N)c34)cc2)c1 CHEMBL1973211 pKi 7.943 nM
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1970104 pKi 7.943 nM
Cc1ccccc1NC(=O)Nc1ccc2c(c1)CCc1sc3ncnc(N)c3c1-2 CHEMBL1982135 pKi 7.943 nM
Nc1ncnc2sc3c(c12)-c1ccc(NC(=O)Nc2ccccc2)cc1CC3 CHEMBL1994693 pKi 7.943 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4c3CNC4=O)cc2)c1 CHEMBL185569 pKi 7.943 nM
CN(C)CC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1982271 pKi 7.943 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 7.943 nM
CN1CCN(Cc2ccc(-c3ccc(CO[C@H]4CCC[C@@H]4NC(=O)c4cc(-c5cnn(C)c5)cnc4N)cc3)cc2)CC1 CHEMBL4857737 pIC50 7.943 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4c3c(N)nn4C)cc2)c1 CHEMBL387312 IC50 8.0 nM
COc1ccc(NC(=O)Nc2ccc(-c3cccc4onc(N)c34)cc2)cc1Cl CHEMBL272453 IC50 8.0 nM
Nc1noc2cccc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c12 CHEMBL410504 IC50 8.0 nM
CCN(CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1)CCOP(=O)(O)O CHEMBL415049 Kd 8.0 nM
CN(C)c1ccc(C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)cc1 CHEMBL1765772 Ki 8.0 nM
CN1CCN(c2ccc(C(=O)Nc3cc(-c4cccc(NS(=O)(=O)c5cccc(Cl)c5)c4)n[nH]3)cc2)CC1 CHEMBL1807467 IC50 8.0 nM
CN1CCN(c2ccc(Nc3nc(N)n(-c4ccccn4)n3)cc2)CC1 CHEMBL1835748 Ki 8.0 nM
COc1cccc(NC(=O)NCc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)c1 CHEMBL1940262 IC50 8.0 nM
N#Cc1cnc(C(=O)Nc2ccc(C3CCN(CCN4CCOCC4)CC3)cc2C2=CCCCC2)[nH]1 CHEMBL2158230 IC50 8.0 nM
Fc1cc2cc(c1)-c1ccnc(n1)Nc1ccc(OCCN3CCCC3)c(c1)COCC=CCOC2 CHEMBL2181312 IC50 8.0 nM
CN1CCN(Cc2ccc(C(=O)Nc3cc(-c4ccc(NC(=O)Nc5cc(C(C)(C)C)on5)cc4)n[nH]3)cc2)CC1 CHEMBL2386794 IC50 8.0 nM
COCCOc1ccn2c(-c3ccc4cccc(O[C@H]5CCNC[C@@H]5F)c4n3)cnc2c1 CHEMBL3109338 IC50 8.0 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc(N5CCN(C(=O)CO)CC5)nn4)nc32)CC1 CHEMBL3237714 IC50 8.0 nM
CS(=O)(=O)CC1CCN(c2ccc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)nn2)CC1 CHEMBL3237715 IC50 8.0 nM
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21 CHEMBL3884319 IC50 8.0 nM
c1ccc(CNc2nccc(-c3cnc4c(NCCN5CCOCC5)nccn34)n2)cc1 CHEMBL3656368 IC50 8.0 nM
CNc1ncc2c(-c3ccc(N4CCN(C)CC4)nc3)nn(CC3CCCC3)c2n1 CHEMBL4208852 IC50 8.0 nM
COCCNCc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)C5(C(=O)Nc6ccc(F)cc6)CC5)cc4F)c3s2)nc1 CHEMBL3989926 IC50 8.0 nM
CC(C)(C)c1csc(NC(=O)Nc2ccc(Oc3ncnc4[nH]ncc34)cc2)n1 CHEMBL4435097 IC50 8.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ncnc4[nH]ncc34)cc2)on1 CHEMBL4435299 IC50 8.0 nM
COc1cc(N2CCCCC2)ccc1NC(=O)c1cnn2ccc(N[C@@H]3CCCNC3)nc12 CHEMBL5086604 IC50 8.0 nM
CNC(=O)c1ccc(F)c(-c2cnc3cc(-c4cnn(C)c4)c(OC)nn23)c1 CHEMBL5202408 IC50 8.0 nM
CNCCOc1ccc(-c2sc3nc(-c4cccs4)nc(NN4C(=O)C=C(C)C4=O)c3c2C)cc1 CHEMBL3966536 IC50 8.026 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCCC(O)CCCC4)cc2)CC1 CHEMBL3967759 IC50 8.1 nM
CCS(=O)(=O)N1CCCc2cc(Nc3ncc(C(F)(F)F)c(NCCCN)n3)ccc21 CHEMBL5430680 IC50 8.1 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(C(=O)Nc3ccccn3)cc2)no1 CHEMBL1079354 Kd 8.15 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3946811 IC50 8.19 nM
CN1CCN(c2ccc(Nc3ncc4ncc(=O)n(-c5ccc(N6CCNCC6)cc5)c4n3)cc2)CC1 CHEMBL4579991 IC50 8.2 nM
Cn1cc(-c2ccc3c(Nc4ccc(NC(=O)Nc5cccc(F)c5)cc4)ncnc3c2)cn1 CHEMBL4784002 IC50 8.237 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc3c(c2)sc2nc(-c4ccc(OCCN5CCOCC5)cc4)cn23)no1 CHEMBL4757873 IC50 8.25 nM
O=S(=O)(NCCOC/C=C/c1ccc(-c2cccnc2)cc1)c1cccc2cnccc12 CHEMBL4566882 pIC50 8.318 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5ncn(Cc6ccccc6F)c5c4)[nH]n3)cc2)CC1 CHEMBL5272321 IC50 8.34 nM
O=C(Nc1ccc(N2CCNCC2)cc1)c1n[nH]cc1Nc1cc(C2CC2)ncn1 CHEMBL5415967 IC50 8.42 nM
O=C(Nc1cc(-c2ccc3c(c2)OCO3)n[nH]1)c1ccc(N2CCOCC2)cc1 CHEMBL4575589 IC50 8.422 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5C(F)(F)F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL2385195 IC50 8.5 nM
O=[N+]([O-])c1ccccc1S(=O)(=O)NCCNC/C=C/c1ccc(-c2cccnc2)cc1 CHEMBL4455301 pIC50 8.511 nM
O=C1Nc2cc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)ccc2/C1=C/c1ccc[nH]1 CHEMBL3322572 IC50 8.6 nM
COc1cc2c(Oc3ccc(C4SCC(=O)N4NC(=O)Nc4ccc(F)cc4F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4446992 IC50 8.6 nM
NCCO/N=C1C(=C2/C(=O)Nc3ccc([N+](=O)[O-])cc32)/Nc2ccc(O)cc2/1 CHEMBL4763626 IC50 8.6 nM
CN1CCN(c2ccc(Nc3ncc4ncc(=O)n(-c5ccc(N)cc5)c4n3)cc2)CC1 CHEMBL4593900 IC50 8.74 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccc(F)cc5)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3343366 IC50 8.78 nM
Cn1cnc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2c1=O CHEMBL5432487 IC50 8.8 nM
CS(=O)(=O)N1CCCc2cc(Nc3ncc(C(F)(F)F)c(NCCCN)n3)ccc21 CHEMBL5406425 IC50 8.86 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCCC(O)CCC4)cc2)CC1 CHEMBL3948030 IC50 8.9 nM
COc1cc2c(Oc3ccc(NC(=O)c4cn(-c5ccccc5Cl)nn4)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL3823520 IC50 8.91 nM
O=S(=O)(NCCNCCCc1ccc(-c2cccnc2)cc1)c1cccc2cnccc12 CHEMBL4532148 pIC50 8.913 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4cc(C#N)cs4)n[nH]3)nc2)CC1 CHEMBL4528422 IC50 8.963 nM
CN1CCN(Cc2ccc3c(c2)Cc2c(-c4csc(C#CCOc5ccccc5)c4)n[nH]c2-3)CC1 CHEMBL390156 IC50 9.0 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)cc1)CCN2 CHEMBL259013 IC50 9.0 nM
O=C1Nc2ccc(S(=O)(=O)[O-])cc2/C1=C1/Nc2ccccc2/C1=N\O CHEMBL1095687 IC50 9.0 nM
CC(=O)Nc1cccc(Nc2nc(N)n(-c3ccccn3)n2)c1 CHEMBL1835866 Ki 9.0 nM
COc1cc2ncnc(Oc3ccc(CC(=O)Nc4ccc(N(C)C)cn4)cc3)c2cc1OC CHEMBL1940118 IC50 9.0 nM
COc1cc2ncnc(Sc3nncs3)c2cc1OC CHEMBL2046726 IC50 9.0 nM
O=C(NCc1ccc(-c2cc(NC(=O)c3ccc(OCCN4CCOCC4)cc3)[nH]n2)cc1)Nc1ccccc1 CHEMBL2386797 IC50 9.0 nM
Cc1cc(NC(=O)Nc2ccc(-c3cc(NC(=O)c4ccc(N5CCN(C)CC5)cc4)[nH]n3)cc2C)no1 CHEMBL2386790 IC50 9.0 nM
CCN1CCN(c2cc(Nc3ncc(-c4ccc(NC(=O)Nc5ccc(Cl)cc5)cc4)s3)nc(C)n2)CC1 CHEMBL3593285 GI50 9.0 nM
O=C(Nc1ccc(CN2CCN(c3ccccc3)CC2)cc1)c1n[nH]c2ccccc12 CHEMBL3792850 IC50 9.0 nM
Cc1cc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)c2c(N)onc2n1 CHEMBL4240969 IC50 9.0 nM
Cc1cnc(Nc2ccc(N3CCC(N(C)CCCO)CC3)c(F)c2)nc1-c1cnn(C(C)C)c1 CHEMBL4560698 IC50 9.0 nM
O=C(CC(F)(F)F)N1CCN(Cc2ccnc(Nc3nc4ccc(-c5cnn(CC6CC6)c5)cc4[nH]3)c2)CC1 CHEMBL4468020 IC50 9.0 nM
Cc1cc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 CHEMBL4552254 IC50 9.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn(CCN4CCNCC4)c4ncnc(N)c34)cc2)no1 CHEMBL4441629 IC50 9.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn(CCCN4CCOCC4)c4ncnc(N)c34)cc2)no1 CHEMBL4572804 IC50 9.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn(CC#N)c4ncnc(N)c34)cc2)no1 CHEMBL4440175 IC50 9.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-n3nc(-c4ccc(OCCN5CCOCC5)cc4)c4c(N)ncnc43)cc2)no1 CHEMBL4101411 IC50 9.0 nM
Cc1cc(NC2CCN(C)CC2)ccc1C(=O)Nc1cc(-c2ccc3ncn(Cc4ccccc4)c3c2)[nH]n1 CHEMBL5280468 IC50 9.06 nM
NC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(N[C@H]3CC[C@H](N)CC3)n2)cc1 CHEMBL5091395 IC50 9.15 nM
NC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(N[C@H]3CC[C@H](O)CC3)n2)cn1 CHEMBL5092589 IC50 9.25 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5C(F)(F)F)c(=O)cc4C)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3290931 IC50 9.28 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5)c(=O)cc4C)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3290929 IC50 9.28 nM
CN1CCN(CCO/N=C2C(=C3/C(=O)Nc4ccccc43)/Nc3ccccc3/2)CC1 CHEMBL4084775 IC50 9.29 nM
CC1(COc2ccc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](O)CC4)n3)cc2)COC1 CHEMBL5424760 IC50 9.46 nM
O=C1Nc2ccc(F)cc2/C1=C1/Nc2ccccc2/C1=N\OCCNC1CCNCC1 CHEMBL4790805 IC50 9.47 nM
CC1=CC(=O)N(Nc2nc(-c3cccs3)nc3sc(-c4ccc(OCCNCc5ccccc5)cc4)c(C)c23)C1=O CHEMBL3924345 IC50 9.478 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5cnc6[nH]ccc6c5)c4c3)cc2)CC1 CHEMBL2436977 IC50 9.5 nM
O=S(=O)(NCCNC/C=C/c1ccc(-c2cccnc2)cc1)c1cccc2cnccc12 CHEMBL4542855 pIC50 9.55 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCC(O)CCCCC4)cc2)CC1 CHEMBL3946971 IC50 9.6 nM
CCN(CC)CCOc1ccc2c(n1)sc1nc(-c3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)cn12 CHEMBL3928660 IC50 9.6 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCCN5CCN(S(C)(=O)=O)CC5)ccc34)cc2)no1 CHEMBL585002 Kd 9.7 nM
Cn1cc(-c2ccn3c(-c4ccc(C(N)=O)s4)cnc3c2)cn1 CHEMBL4868026 IC50 9.7 nM
O=S(=O)(NCCNC/C=C/c1ccc(-c2cccnc2)cc1)c1ccc2[nH]ncc2c1 CHEMBL4472305 pIC50 9.772 nM
CC(=O)N1CCc2ccc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)cc21 CHEMBL5420872 IC50 9.84 nM