COc1ccc(-n2[nH]c3c(cnc4ccccc43)c2=O)cc1 CHEMBL3144739 Kd 0.1 nM
CCOC(=O)c1ncc2[nH]c3ccc(OC)cc3c2c1COC CHEMBL5280240 Ki 0.1 nM
O=C1C2C=Nc3ccccc3C2=NN1c1ccc(Cl)cc1 CHEMBL20042 Kd 0.3 nM
CCOC(=O)c1ncn2c1c(=O)n(Cc1cccnc1)c1ccccc12 CHEMBL5268764 Ki 0.4 nM
Cc1cc(-c2nnc3c4ccccc4c(OCc4ccccn4)nn23)no1 CHEMBL68684 Ki 0.4 nM
CCCNC(=O)c1nnc2c(-c3c(F)cccc3OC)cccc2c1N CHEMBL1783282 Ki 0.5 nM
CCCNC(=O)c1nnc2c(-c3cc(OC)ccc3OC)cccc2c1N CHEMBL1783256 Ki 0.5 nM
CCCOc1ccc2[nH]c3cnc(C(=O)OCC)c(COC)c3c2c1 CHEMBL49141 Ki 0.5 nM
CCOC(=O)c1ncc2[nH]c3ccccc3c2c1COC CHEMBL5266498 Ki 0.6 nM
CC(C)(C)OC(=O)c1cc2c(cn1)[nH]c1ccccc12 CHEMBL509197 Ki 0.7 nM
CC(C)(O)c1cnn2c(-c3ccc(F)c(-c4c(F)cccc4C#N)c3)cnc2n1 CHEMBL204696 Ki 0.73 nM
CCOC(=O)c1ncn2c1CN(C)C(=O)c1cc(F)ccc1-2 CHEMBL407 pKi 0.7943 nM
Cc1cc(-c2nncc3c(C(C)(C)C)c(OCc4ncnn4C)nn23)no1 CHEMBL363211 Ki 0.8 nM
Cc1cc(-c2nnc3c4ccccc4c(OCc4cn(C)nn4)nn23)no1 CHEMBL306422 Ki 0.88 nM
COC(=O)c1cc2c(cn1)[nH]c1ccccc12 CHEMBL453066 Kd 1.0 nM
Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2 CHEMBL646 Kd 1.0 nM
CC(C)(C)OC(=O)c1cc2c3ccccc3nc-2c[nH]1 CHEMBL307783 Kd 1.0 nM
CCOC(=O)c1cc2c3ccccc3nc-2c[nH]1 CHEMBL11709 Kd 1.0 nM
COCc1c(C(=O)OC(C)C)ncc2[nH]c3ccc(OCc4ccccc4)cc3c12 CHEMBL454095 Kd 1.0 nM
Fc1ccccc1-n1nc2c(cnc3ccccc32)c1OCc1ccccc1Cl CHEMBL1681887 IC50 1.0 nM
CCOC(=O)c1cc2c(cn1)[nH]c1ccccc12 CHEMBL454606 Ki 1.0 nM
C#Cc1ccc2[nH]c3cnc(C(=O)OC(C)(C)C)cc3c2c1 CHEMBL1270038 Ki 1.0 nM
c1ccc2c(c1)[nH]c1c2ncc2[nH]c3ccccc3c21 CHEMBL301605 Ki 1.0 nM
CCOC(=O)c1ncn2c1CN(C)C(=O)c1cc(N=[N+]=[N-])ccc1-2 CHEMBL6597 EC50 1.1 nM
CCOc1cc2c3ccccc3nc-2c[nH]1 CHEMBL299250 Kd 1.2 nM
COc1ncccc1-c1cc(-n2cnc3cc(C(C)(C)O)ccc32)ccn1 CHEMBL3659674 IC50 1.2 nM
Cc1csc(-c2cc(-c3ccncc3)c3n(c2=O)CCCc2ccncc2-3)n1 CHEMBL45198 Ki 1.3 nM
CCCC(=O)c1cc2c(cn1)[nH]c1ccccc12 CHEMBL510764 Ki 2.0 nM
CCOC(=O)c1ncc2[nH]c3ccc(O)cc3c2c1COC CHEMBL5290464 Ki 2.0 nM
c1ccc2c(c1)[nH]c1cnc3c4cccnc4[nH]c3c12 CHEMBL2008708 Ki 2.0 nM
COc1ccc2c(c1)[nH]c1c2ncc2[nH]c3ccccc3c21 CHEMBL497197 Ki 3.0 nM
c1ccc2c(c1)[nH]c1cnc3c4ccncc4[nH]c3c12 CHEMBL5281056 Ki 3.0 nM
Cc1ncc(Cn2c(=O)c3cncn3c3ccccc32)cn1 CHEMBL5283158 Ki 3.6 nM
CCOC(=O)c1ncc2[nH]c3ccc(OCc4ccccc4)cc3c2c1COC CHEMBL1518572 Ki 4.0 nM
Clc1ccc2c(c1)[nH]c1c2ncc2[nH]c3ccccc3c21 CHEMBL496990 Ki 4.0 nM
CN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21 CHEMBL13280 Kd 4.5 nM
CCCOc1cc2c3ccccc3nc-2c[nH]1 CHEMBL52750 Kd 5.0 nM
S=C=Nc1cc2c(cn1)[nH]c1ccccc12 CHEMBL2262044 Ki 5.0 nM
COC(=O)c1cc2c(cn1)[nH]c1ccc(NCc3ccccc3)cc12 CHEMBL5290746 Ki 5.0 nM
O=c1c2c(Cl)ncn2c2ccccc2n1Cc1ccccn1 CHEMBL5267248 Ki 5.4 nM
CCc1c(C(=O)OC)nc(C)c2[nH]c3cc(OC)c(OC)cc3c12 CHEMBL5290579 Ki 6.0 nM
CCOC(=O)c1nc(C)c2[nH]c3cc(OC)c(OC)cc3c2c1CC CHEMBL5275690 Ki 6.0 nM
CCOC(=O)c1ncn2c1c(=O)n(Cc1cccnc1)c1cccc(Cl)c12 CHEMBL5279431 Ki 7.0 nM
CC(C)(O)c1ccc2c(c1)ncn2-c1ccnc(-c2ccncc2F)c1 CHEMBL3659676 IC50 7.5 nM
CCOC(=O)c1[nH]cc2nc3cc(OC)c(OC)cc3c-2c1CC CHEMBL85861 Kd 8.0 nM
Cc1ncn2c1c(=O)n(Cc1cccnc1)c1ccccc12 CHEMBL5279584 Ki 8.0 nM
O=C1C2C=Nc3ccccc3C2=NN1c1ccccc1 CHEMBL19732 Kd 8.3 nM
Cc1ccc(-c2nc3ccc(C)cn3c2CC(=O)N(C)C)cc1 CHEMBL911 IC50 14.0 nM
Clc1ccc2c(c1)-c1ncnn1Cc1c(Cl)ncn1-2 CHEMBL1077391 Ki 15.0 nM
O=c1c2cncn2c2ccc(Cl)cc2n1Cc1cccnc1 CHEMBL5276178 Ki 15.0 nM
CN1C(=O)CN=C(c2ccccc2)c2cc(Cl)ccc21 CHEMBL12 Ki 16.0 nM
Cc1ncn2c1c(=O)n(Cc1ccccn1)c1ccccc12 CHEMBL5285179 Ki 16.0 nM
Oc1nc2c(c3nc(-c4ccccc4)cn13)CN(Cc1ccccc1)CC2 CHEMBL148740 EC50 17.0 nM
CCOC(=O)c1ncn2c1[C@@H]1CCCN1C(=O)c1cc(OC)ccc1-2 CHEMBL52030 Ki 17.0 nM
Oc1nc2c(c3nc(-c4ccccc4F)cn13)CN(Cc1ccccc1)CC2 CHEMBL356161 EC50 18.0 nM
COc1ccc2c(c1)O[C@@H](c1ccc(OC)c(OC)c1)C[C@H]2NC(=O)C1(c2ccc3c(c2)OC(F)(F)O3)CC1 CHEMBL4093612 Ki 19.59 nM
CCOC(=O)C1=NCN2c3ccc(CC)cc3C(=O)N(C)CC12 CHEMBL454865 Kd 20.4 nM
CC1=C(C#N)C(c2ccc3c(c2)c(NC(=O)c2ccccc2C)nn3C)C(C#N)=C(C)N1 CHEMBL4630642 Ki 20.99 nM
O=c1c2c(CC3CC3)ncn2c2ccccc2n1Cc1ccccn1 CHEMBL5289385 Ki 23.0 nM
CC(C)(O)c1ccc2c(c1)ncn2-c1ccnc(-c2ccncc2C#N)c1 CHEMBL3659677 IC50 26.0 nM
COc1ccc(-c2cn3c(O)nc4c(c3n2)CN(Cc2ccccc2)CC4)cc1 CHEMBL356271 EC50 28.0 nM
O=c1c2cncn2c2ccccc2n1Cc1cncnc1 CHEMBL5267241 Ki 30.0 nM
O=c1c2cncn2c2ccccc2n1Cc1cccnc1 CHEMBL5271002 Ki 32.0 nM
Cc1cc(Cn2c(=O)c3cncn3c3ccccc32)no1 CHEMBL5266848 Ki 32.0 nM
CC(OC(=O)c1cc2c(cn1)[nH]c1ccccc12)c1ccccc1 CHEMBL1270841 Ki 34.0 nM
Cc1ccc(Cn2c(=O)c3cncn3c3ccccc32)cn1 CHEMBL5283624 Ki 35.0 nM
Oc1nc2c(c3nc(-c4cc(F)ccc4F)cn13)CN(Cc1ccccc1)CC2 CHEMBL145910 EC50 36.0 nM
Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2 CHEMBL661 EC50 37.0 nM
CC(C)(O)c1ccc2c(c1)ncn2-c1ccnc(-c2cccnc2Cl)c1 CHEMBL3659675 IC50 38.0 nM
O=C(c1ccc(F)cc1)N1CCc2nc(O)n3cc(-c4ccccc4F)nc3c2C1 CHEMBL147842 EC50 41.0 nM
Clc1ccc(-n2nc3c4c(ncc3c2OCc2ccccc2Cl)CCCC4)cc1 CHEMBL1681889 IC50 46.0 nM
Clc1ccccc1COc1c2cnc3ccccc3c2nn1-c1ccc2c(c1)OCO2 CHEMBL1681888 IC50 50.0 nM
Fc1ccc(COc2c3cnc4c(c3nn2-c2ccc(Cl)cc2)CCCC4)cc1 CHEMBL1681897 IC50 50.0 nM
CN1CCN(C(=O)O[C@H]2c3nccnc3C(=O)N2c2ccc(Cl)cn2)CC1 CHEMBL1522 Ki 50.1 nM
O=c1c2cncn2c2ccccc2n1Cc1ccccn1 CHEMBL5272593 Ki 52.0 nM
Oc1nc2c(c3nc(-c4ccccc4F)cn13)CN(Cc1ccncc1)CC2 CHEMBL342270 EC50 53.0 nM
O=c1c2cncn2c2ccccc2n1Cc1cnccn1 CHEMBL5287850 Ki 55.0 nM
Oc1nc2c(c3nc(-c4ccccc4F)cn13)CN(Cc1cccnc1)CC2 CHEMBL146086 EC50 56.0 nM
Cc1ccncc1Cn1c(=O)c2cncn2c2ccccc21 CHEMBL5281879 Ki 60.0 nM
Cc1cncc(Cn2c(=O)c3cncn3c3ccccc32)c1 CHEMBL5282000 Ki 60.0 nM
Clc1ccc(-n2nc3c(cnc4ccccc43)c2OCc2ccccc2Cl)cc1 CHEMBL1681886 IC50 64.0 nM
Fc1ccccc1COc1c2cnc3c(c2nn1-c1ccc(Cl)cc1)CCCC3 CHEMBL1681895 IC50 64.0 nM
CC1(C)CCc2ncc3c(OCc4ccccc4Cl)n(-c4ccc(Cl)cc4)nc3c2C1 CHEMBL1681892 IC50 67.0 nM
O=C(c1cccc(F)c1)N1CCc2nc(O)n3cc(-c4ccccc4F)nc3c2C1 CHEMBL356806 EC50 69.0 nM
c1ccc(-c2nnc3c4c(c(OCc5ccccn5)nn23)C2CCC4CC2)cc1 CHEMBL178942 Ki 71.0 nM
Clc1ccc(-n2nc3c(cnc4ccccc43)c2OCC2CC2)cc1 CHEMBL1681885 IC50 74.0 nM
CN1C(=O)COc2cc(Cn3c(=O)c4cncn4c4ccccc43)ccc21 CHEMBL5285035 Ki 74.0 nM
C#Cc1ccc2c(c1)C(c1ccccc1)=NCC(=O)N2C CHEMBL174535 Kd 76.0 nM
O=c1c2cncn2c2ccc(Br)cc2n1Cc1cccnc1 CHEMBL5284313 Ki 76.0 nM
COc1cccc(-c2cn3c(O)nc4c(c3n2)CN(Cc2ccccc2)CC4)c1 CHEMBL146356 EC50 81.0 nM
CC(=O)Nc1c(C(C)=O)c(=O)n(C)c2nc(-c3ccc(Cl)cc3Cl)c(-c3ccc(Cl)cc3)cc12 CHEMBL204232 Ki 82.0 nM
CCOC(=O)c1ncn2c1[C@@H]1CCN1C(=O)c1cc(C#C[Si](C)(C)C)ccc1-2 CHEMBL130416 Kd 83.0 nM
Oc1nc2c(c3nc(-c4ccc(F)cc4F)cn13)CN(Cc1ccccc1)CC2 CHEMBL343009 EC50 92.0 nM
O=C(c1ccccc1F)N1CCc2nc(O)n3cc(-c4ccccc4F)nc3c2C1 CHEMBL146302 EC50 93.0 nM
Clc1ccc(-n2nc3c4c(ncc3c2OCC2CC2)CCCC4)cc1 CHEMBL1681900 IC50 94.0 nM
CCC(=O)N1CCc2nc(O)n3cc(-c4ccccc4F)nc3c2C1 CHEMBL358519 EC50 95.0 nM
O=c1c2c(CO)ncn2c2ccccc2n1Cc1cccnc1 CHEMBL5287391 Ki 100.0 nM
Oc1nc2c(c3nc(-c4ccccc4F)cn13)CN(Cc1cccs1)CC2 CHEMBL147364 EC50 107.0 nM
Oc1nc2c(c3nc(-c4ccccc4F)cn13)CN(Cc1c[nH]cn1)CC2 CHEMBL358874 EC50 118.0 nM
Oc1nc2c(c3nc(-c4cccc(F)c4)cn13)CN(Cc1ccccc1)CC2 CHEMBL145983 EC50 120.0 nM
COc1ccc2c(c1)n(Cc1cccnc1)c(=O)c1cncn12 CHEMBL5276982 Ki 120.0 nM
CCOC(=O)c1ncn2c3ccc(C#C[Si](C)(C)C)cc3c(=O)n(C)c12 CHEMBL461716 Kd 121.0 nM
Cn1cc(Cn2c(=O)c3cncn3c3ccccc32)cn1 CHEMBL5283694 Ki 123.0 nM
Oc1nc2c(c3nc(-c4ccccc4F)cn13)CN(CC1CCCCC1)CC2 CHEMBL146230 EC50 127.0 nM
O=C(c1ccc(F)c(F)c1)N1CCc2nc(O)n3cc(-c4ccccc4F)nc3c2C1 CHEMBL147590 EC50 133.0 nM
Clc1ccc(-n2nc3c(cnc4ccc(-n5ccnc5)cc43)c2OCC2CC2)cc1 CHEMBL1681899 IC50 134.0 nM
Oc1nc2c(c3nc(-c4ccccc4F)cn13)CN(CC1CC1)CC2 CHEMBL145970 EC50 135.0 nM
Oc1nc2c(c3nc(-c4ccc(F)cc4)cn13)CN(Cc1ccccc1)CC2 CHEMBL148044 EC50 136.0 nM
Cc1c(F)c(Nc2ccc(-c3cn(C)cn3)cn2)cc2c1ncn2CC1CC1 CHEMBL4581355 Ki 140.0 nM
COc1cccc(F)c1C1=NCc2cnc(Nc3ccc(C(=O)O)cc3)nc2-c2ccc(Cl)cc21 CHEMBL3586473 IC50 150.0 nM
Clc1ccc(COc2c3cnc4c(c3nn2-c2ccc(Cl)cc2)CCCC4)cc1 CHEMBL1681894 IC50 157.0 nM
C=CCN1CCc2nc(O)n3cc(-c4ccccc4F)nc3c2C1 CHEMBL358301 EC50 170.0 nM
FC(F)c1ncn2c1Cn1ncnc1-c1cc(Br)ccc1-2 CHEMBL1080588 Ki 174.0 nM
O=c1c(Cc2ccccc2)c[nH]c2c(-c3ccccn3)cnn12 CHEMBL4086946 Ki 183.0 nM
Cn1c(=O)c2cc(C#C[Si](C)(C)C)ccc2n2cnc(C(=O)OC(C)(C)C)c12 CHEMBL461717 Kd 197.0 nM
CCOC(=O)c1ncn2c1C1CCCN1C(=O)c1cc(C#C[Si](C)(C)C)ccc1-2 CHEMBL518197 Kd 200.0 nM
Oc1nc2c(c3nc(-c4ccccc4-c4cccs4)cn13)CN(Cc1ccccc1)CC2 CHEMBL148043 EC50 208.0 nM
Cc1cc(C)c(-n2ccn3nc(-c4cccnc4)cc23)cc1NC(=O)c1cc(C#N)cc(S(F)(F)(F)(F)F)c1 CHEMBL3907057 Ki 217.26 nM
COc1ccc2c(c1)O[C@H](c1ccc(OC)c(OC)c1)C[C@@H]2NC(=O)C1(c2ccc3c(c2)OC(F)(F)O3)CC1 CHEMBL4066040 Ki 217.72 nM
CCNC(=O)c1cc2c(N3CCOC[C@@H]3C)ccnc2n1C CHEMBL4084419 Ki 224.0 nM
Clc1ccc(-n2nc3c4c(ncc3c2OCc2ccccc2Cl)CCCCC4)cc1 CHEMBL1681890 IC50 242.0 nM
CCOC(=O)c1ncn2c1CN(C)C(=O)c1cc(N=C=S)ccc1-2 CHEMBL485829 EC50 250.0 nM
NS(=O)(=O)c1cc(NC(=O)C2(c3ccccc3Cl)CC2)ccc1Oc1cccc(Cl)c1 CHEMBL4516843 Ki 250.13 nM
CCCCN1CCc2nc(O)n3cc(-c4ccccc4F)nc3c2C1 CHEMBL147379 EC50 258.0 nM
Cc1ccc(-c2cn3c(O)nc4c(c3n2)CN(Cc2ccccc2)CC4)cc1 CHEMBL147312 EC50 266.0 nM
Cc1ccc(C(=O)N2CCc3nc(O)n4cc(-c5ccccc5F)nc4c3C2)cc1 CHEMBL343471 EC50 303.0 nM
CC(C)(C)c1ccc2c(c1)n(Cc1cccnc1)c(=O)c1cncn12 CHEMBL5281265 Ki 310.0 nM
O=C(O)c1ccc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2F)=NC3)cc1 CHEMBL259084 IC50 330.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 Ki 346.58 nM
COCc1ncn2c1CN(C)C(=O)c1cc(Cl)ccc1-2 CHEMBL45346 Ki 362.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 Ki 374.92 nM
O=c1c2cncn2c2c(Cl)cc(Cl)cc2n1Cc1cccnc1 CHEMBL5275441 Ki 420.0 nM
CSc1nccc(-c2ccc(S(=O)(=O)Nc3ccc(Cl)cc3)s2)n1 CHEMBL458317 IC50 470.0 nM
CC1=NN=C(c2cc3c(C(F)(F)F)cccc3s2)c2cc3oc(=O)[nH]c3cc2C1 CHEMBL3652872 IC50 479.0 nM
COc1cc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2OC)=NC3)ccc1C(=O)O CHEMBL483158 IC50 490.0 nM
C#Cc1ccc2c(c1)C(c1ccccc1F)=N[C@H](C)c1c(C(=O)NC3CC3)ncn1-2 CHEMBL4553352 Ki 542.0 nM
Cc1ccccc1C(=O)N1CCc2nc(O)n3cc(-c4ccccc4F)nc3c2C1 CHEMBL344120 EC50 544.0 nM
CSC1SC(C(=O)c2ccc(Cl)cc2)C2CC(C)(C)CC(=O)C12 CHEMBL458144 IC50 580.0 nM
CSC1SC(C(=O)c2ccc(Cl)cc2)C2CCCC(=O)C12 CHEMBL511684 IC50 580.0 nM
Cc1cccc2c1n1cncc1c(=O)n2Cc1cccnc1 CHEMBL5272704 Ki 600.0 nM
COc1cc(Cl)c2c(c1)n(Cc1cccnc1)c(=O)c1cncn12 CHEMBL5276966 Ki 670.0 nM
Cc1ccc(-c2cnc([C@@]3(O)CC[C@H](C(=O)O)C(C)(C)C3)s2)cc1Nc1cccc(C(F)(F)F)n1 CHEMBL4530401 Ki 774.0 nM
CN(C)CC#Cc1ccc(OCCCc2sc(N3CCc4cccc(C(=O)Nc5nc6ccccc6s5)c4C3)nc2C(=O)O)c(F)c1 CHEMBL3342332 Ki 793.96 nM
C#Cc1ccc2c(c1)C(c1ccccc1F)=N[C@H](C)c1c(C(=O)NC)ncn1-2 CHEMBL4228824 Ki 850.0 nM
O=c1nc(-c2ccccn2)sc2ccccc12 CHEMBL4516611 Ki 934.0 nM
Cc1onc(-c2ccc(F)cc2)c1COc1ccc(C(=O)N2CCS(=O)(=O)CC2)cn1 CHEMBL3681419 Ki 985.0 nM
Nc1c(C(=O)c2ccc(Cl)cc2)sc2ccccc12 CHEMBL461925 IC50 1000.0 nM